Digital Commons Network^™

Association Between Household Insecticide Exposure (Indoor Risidual Spray For Malaria Control) And Child Cognitive Development: An Assessment Of Cross-Sectional Surveys, Megan A. Wilkens

Renée Crown University Honors Thesis Projects - All

No abstract provided.

Determining Cause Of Death With Machine Learning: Automatic Analysis Of Verbal Autopsies And Interpretability Of Results, Cheyene Muenzel

Renée Crown University Honors Thesis Projects - All

No abstract provided.

Vision 2022

Vision

No abstract provided.

2022 Spring Commencement, Georgia Southern University

Commencement Programs

No abstract provided.

Taxonomy And Restorative Justice: Can We Even See The Problem?, Dominique Day

Journal of Race, Gender, and Ethnicity

No abstract provided.

Investigating The Interplay Of The Immune System, Skin Barrier, And Microbiome Following Dermal Exposure To Triclosan, Rachel Baur

Graduate Theses, Dissertations, and Problem Reports (ETD)

Triclosan is an antimicrobial chemical used in healthcare products that are applied to the skin. However, exposure to triclosan has been positively associated with food allergy, aeroallergy, and asthma severity in humans. In mice, dermal triclosan exposure, although not directly sensitizing, has been shown to augment the allergic response in a model of asthma. Furthermore, exposure to triclosan on mouse skin has been demonstrated to be immunomodulatory through the activity of thymic stromal lymphopoietin and S100 calcium-binding protein A8. The skin barrier and microbiome are known to interact with the immune system and disruptions in barrier integrity and the microbiome …

Zonulin As A Mediator Of Psychological Stress And Periodontal Disease, Casey D. Wright

Graduate Theses, Dissertations, and Problem Reports (ETD)

The prevalence of chronic inflammatory diseases is on the rise. Some have posited the permeability of tight junctions in gastrointestinal epithelium tissues as a potential mechanism for precipitating inflammatory processes throughout the body. Zonulin is the only known modulator of tight junction permeability and has been implicated in numerous chronic inflammatory processes (e.g., proinflammatory cytokine production) and diseases, more generally. The role of zonulin in oral inflammation, however, has yet to be explored. Periodontal disease is the most common oral inflammatory condition and primary perpetrator of tooth loss. Periodontal disease also is associated with a number of other health problems …

Utilizing The K18-Hace2 Mouse Model To Develop Protective Covid-19 Vaccines, Ting Y. Wong

Graduate Theses, Dissertations, and Problem Reports (ETD)

The ongoing Coronavirus Disease 2019 (COVID-19) pandemic is caused by the respiratory virus Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Similar to other respiratory viruses, SARS-CoV-2 is transmitted through inhalation of respiratory droplets and aerosols from infected individuals. Once inhaled, SARS-CoV-2 utilizes the receptor binding domain (RBD) on the spike protein to bind to human Angiotensin Converting Enzyme 2 (hACE2) receptor to gain entrance into host cells to begin viral replication. SARS-CoV-2 infection can result in mild to severe cases of COVID-19 ranging from asymptomatic infections, cold or flu like symptoms to respiratory failure. The onset of the pandemic in …

Factors Influencing Intestinal Parasite In Black-And-White Ruffed Lemurs (Varecia Variegata), Eliette Noromalala

All Master's Theses

Ecological factors, such as feeding behavior and climatic seasonality, might influence intestinal parasite infection and patterns in non-human primates. Here, we examined if frugivory levels and climate (i.e., temperature and rainfall) were associated with parasite patterns in black-and-white ruffed lemurs (Varecia variegata). Feeding data using 5-min focal sampling, climate data, and fecal samples from V. variegata (n = 23) at the “Mangevo” site were collected from February through May 2019. Microscopic examinations of fecal flotation and sedimentation were done to identify and count parasites. Nematoda (Callistoura vauceli, and Strongyloides sp.) Ciliophora (Balantidium sp.), Coccidia ( …

Development Of Novel Pyridazine Derivatives And Drug Delivery Systems Against Dengue, Janae A. Culmer

College of Graduate Studies: Theses & Dissertations

The lack of approved vaccines, medications and treatment regimens has significantly contributed to the rapid spread of mosquito-borne viruses such as Dengue and Zika virus. The complex immunopathology of these viruses presents limitations for the development and implementation of a definitive, safe and effective approach to combat infections.Previous research has demonstrated that vector control strategies such as the elimination of larval habitats, larviciding with insecticides, the use of biological agents and the application of adulticides have been unsuccessful in the reduction of viral transmission leading to the need for the continued development of antivirals. This research proposes an approach for …

A Proportionality-Based Framework For Government Regulation Of Digital Tracing Apps In Times Of Emergency, Sharon Bassan

Dickinson Law Review (2017-Present)

Times of emergency present an inherent conflict between the public interest and the preservation of individual rights. Such times require granting emergency powers to the government on behalf of the public interest and relaxing safeguards against government actions that infringe rights. The lack of theoretical framework to assess governmental decisions in times of emergency leads to a polarized and politicized discourse about potential policies, and often, to public distrust and lack of compliance.

Such a discourse was evident regarding Digital Tracing Apps (“DTAs”), which are apps installed on cellular phones to alert users that they were exposed to people who …

Primary Care Characteristics And Medication Management Among Patients Receiving Office Based Opioid Treatment With Buprenorphine, Xinxin Du

Yale Medicine Thesis Digital Library

AbstractBackground: Office-based opioid treatment (OBOT) is an evidence-based treatment model for opioid use disorder (OUD) offered by both addiction and general primary care providers (PCPs). Calls exist for more PCPs to offer OBOT. Few studies have been conducted on the primary care characteristics of OBOT patients. Objective: To characterize medical conditions, medications, and treatment outcomes among patients receiving office-based opioid treatment (OBOT) with buprenorphine for OUD, and to describe differences among patients by age and by time in care. Methods: This study is a retrospective review of medical records on or before 4/29/2019 at an outpatient primary care clinic within …

Policies And Regulations Surrounding Opioid Use Disorder During Covid-19, Hannah Eaves

Student Works

No abstract provided.

Secrecy Nurtures Disease: Balancing Privacy Concerns With Covid-19 Contact-Tracing Measures, Julianna Dzwierzynski

Student Works

No abstract provided.

Investigating The Main Protease (Mpro) Of Sars-Cov-2 As A Potential Drug Target, Valerie Giovina Pascetta

Honors Theses and Capstones

The rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the coronavirus disease 19 (COVID-19) pandemic has claimed the lives of roughly 6.2 million people worldwide as of May 2022. The virus’s main protease (M^pro ) has been identified as an attractive drug target due to the critical role it plays in the viral life cycle. The roughly 34 kDa M^pro cleaves functional viral polypeptides out of two long polyproteins at conserved cut sites, allowing them to fulfill their role in processes like transcription and replication. Here, we have studied the enzymatic activity …

Appropriateness Of Vancomycin Use And Associated Outcomes, Sehajvir Singh, Avi Prajapati, Trevor Van Schooneveld, Manish Tiwari

Posters: 2022 Summer Undergraduate Research Program

Background:

Several studies have documented increased rates of MRSA associated with adverse patient outcomes. Vancomycin remains the primary treatment of choice and use of vancomycin in hospitalized settings is increasing. Inappropriate vancomycin has been shown to lead to the development of vancomycin resistant organisms. Guidelines developed by IDSA have been used to promote appropriate use of vancomycin. However, inappropriate use of vancomycin remains high and its association with patient outcomes has not been well examined. The objective of this study was to examine appropriateness of vancomycin use and associated outcomes based on IDSA guidelines.

Methods:

A retrospective observational study of …

Meta-Analysis Of Major Histocompatibility Complex (Mhc) Class Iia Reveals Polymorphism And Positive Selection In Many Vertebrate Species, Donald Dearborn, Sophie Warren, Frank Hailer

All Faculty Scholarship

Pathogen-mediated selection and sexual selection are important drivers of evolution. Both processes are known to target genes of the major histocompatibility complex (MHC), a gene family encoding cell-surface proteins that display pathogen peptides to the immune system. The MHC is also a model for understanding processes such as gene duplication and trans-species allele sharing. The class II MHC protein is a heterodimer whose peptide-binding groove is encoded by an MHC-IIA gene and an MHC-IIB gene. However, our literature review found that class II MHC papers on infectious disease or sexual selection included IIA data only 18% and 9% of the …

Battleground Of The Opioid Crisis: The Eighth Amendment Right To Medication-Assisted Treatment In Prisons And Jails, And Upon Release, Claire E. Scavone

Emory Law Journal

About eighty percent of all inmates in the United States need but will not receive treatment for their Opioid Use Disorder (OUD). Instead, they will leave prison with a 140 times greater chance of a fatal overdose than before their prison sentence. Although incarceration is conceivably an opportune time for the state to connect individuals with treatment, only about one percent of prisons and jails allow the use of Medication-Assisted Treatment (MAT). This failure has a myriad of causes. Notably, beliefs that OUD is a moral failure and that MAT either does not work or is dangerous are both among …

The Case Of Singapore, Hwee Kwan Chow, Kong Weng Ho

Research Collection School of Economics

The economic impact of the Covid-19 pandemic on Singapore was more severe and protracted than the global financial crisis. Singapore responded with easing of the monetary policy stance, reinforcing financial stability, helping individuals to reduce debt obligations, easing business cashflow constraints, adjusting financial regulatory and supervisory protocols to cope with immediate challenges, and enabling the financial sectors to build long-term capabilities. Fiscal responses were unprecedented with four consecutive budgets and two ministerial statements, initially focusing on immediate assistance in respect of jobs, businesses, households, and later refined to providing more sector-specific assistance as the pandemic evolved with more detailed information …

Nanomaterials In Theranostics : Therapeutics And Diagnosis Against Infectious Diseases, Unnatiben S. Patel

Dissertations

Nanomaterials-based hybrid nano therapy is gaining attraction as a promising way to treat intracellular bacterial infections. Gold-based nanomaterials have been widely used for biomedical applications such as photothermal therapy (PTT). This thesis discusses the development of a combination therapeutic approach that kills intracellular bacteria in conjunction with photothermal and antibiotic therapy using gold nanorod (GNR) based nano-assembly. This NIR laser-activated nano-assembly delivers antibiotics to the site of infection and offers PTT. The synergistic application of both therapies increases the efficacy of treatment. The protected delivery of antibiotics and their release in the proximity of the bacterial surface decreases off-target toxicity …

Development Of Paper-Based Electrochemical Device For Detection Of Biomarker Of Infectious Diseases, Chawin Srisomwat

Chulalongkorn University Theses and Dissertations (Chula ETD)

This dissertation focused on the development of novel point-of-care (POC) testing devices with luminescent and electrochemical detection techniques for the detection of nucleic acid in infectious diseases. This content can be classified into two main parts: (1) the development of a POC sensing device with luminescent detection, and (2) the development of POC testing devices with electrochemical detection. In the first part, an alternating current electroluminescent device for the detection of HIV and HCV cDNA with a label-free platform was developed. The luminosity of the device increased in the presence of the target DNA. The negative charge on the backbone …

Tennessee Forestry Commission 2020 Annual Report, Tennessee. Department Of Agriculture.

Forestry Commission Annual Report

No abstract provided.

Impacts Of Covid-19 On Global Healthcare Management And Research, Stephanie Autore, Santanu De

Biology Faculty Articles

The Coronavirus Infectious Disease 2019 (COVID-19) pandemic has affected most nations at all levels of functioning, individual to governmental. Therefore, it is imperative to evaluate the effects the virus has had on one of the most important socioeconomic global sectors, healthcare. This literature review explores key, recent research and management strategies that have been undertaken in healthcare systems around the world in order to make meaningful attempts at identifying the etiology, diagnosis, and treatment of the disease, and combating the spread of this deadly virus. Healthcare facilities have implemented a variety of changes, all geared towards reducing non-emergency patient visits …

Economic Valuation Of Pfas Remediation In New Hampshire Municipal Drinking Water Systems: A Contingent Valuation Approach, Tristan Colby Price

Master's Theses and Capstones

In the past two decades there has been an increase in detection and awareness of PFAS (Per- or Polyfluoroalkyl substances) chemicals in groundwater and drinking water in the United States. In stark contrast to other known harmful chemical pollutants, little is known yet about the specific epidemiological and toxicological effects of prolonged intake and consumption of PFAS chemicals in environmentally occurring levels. New Hampshire in particular has encountered two high-profile episodes of PFAS contamination with hotspots in Merrimack, NH due to factory pollution and Pease International Tradeport in Portsmouth, NH due to military activity. These instances have brought increased attention …

Metaproteomic Analysis Of Gut Resistome In The Cecal Microbiota Of Fattening Pigs Raised Without Antibiotics, Pamornya Buthasane

Chulalongkorn University Theses and Dissertations (Chula ETD)

Improper use of antibiotics in swine could reduce commensal bacteria and possibly increase pathogen infections via the gut resistome. This study aimed to compare the metaproteomic profiles of gut resistome and related metabolism in the cecal microbiota of fattening pigs raised under antibiotic-free (ABF) conditions with those of ordinary industrial pigs (controls, CTRL). The top three relative abundant microbials in both groups were Escherichia coli, Ruminococcus and Lactobacillus, followed by Bacteroides and Bifidobacterium. E. coli, Lactobacillus and Bacteroides were found to be increased in the CTRL group, whereas Ruminococcus and Clostridium were greater in the ABF group. The highest abundance …

Week 96 Extension Results Of A Phase 3 Study Evaluating Long-Acting Cabotegravir With Rilpivirine For Hiv-1 Treatment, Susan Swindells, Thomas Lutz, Lelanie Van Zyl, Norma Porteiro, Matthias Stoll, Essack Mitha, Alyssa Shon, Paul Benn, Jenny O. Huang, Conn M. Harrington, Kai Hove, Susan L. Ford, Christine L. Talarico, Vasiliki Chounta, Herta Crauwels, Rodica Van Solingen-Ristea, Simon Vanveggel, David A. Margolis, Kimberly Y. Smith, Kati Vandermeulen, William R. Spreen

Journal Articles: Infectious Diseases

BACKGROUND: ATLAS (NCT02951052), a phase 3, multicenter, open-label study, demonstrated that switching to injectable cabotegravir (CAB) with rilpivirine (RPV) long-acting dosed every 4 weeks was noninferior at week (W) 48 to continuing three-drug daily oral current antiretroviral therapy (CAR). Results from the W 96 analysis are presented.

METHODS AND DESIGN: Participants completing W 52 of ATLAS were given the option to withdraw, transition to ATLAS-2M (NCT03299049), or enter an Extension Phase to continue long-acting therapy (Long-acting arm) or switch from CAR to long-acting therapy (Switch arm). Endpoints assessed at W 96 included proportion of participants with plasma HIV-1 RNA less …

Elderly, Detained, And Justice-Involved: The Most Incarcerated Generation, Rachael Bedard, Joshua Vaughn, Angela Silletti Murolo

City University of New York Law Review

The “graying” of the United States prison system is a well-documented phenomenon that describes the aging of the population currently held in U.S. state and federal prisons. This is generally attributed to the large number of individuals who are aging in place in prisons around the country due to long sentences and restrictive parole practices. Less well-known or well-characterized is the fact that the U.S.’s justice-involved population outside of prisons is also “graying”—that the demographics of people who are being arrested, jail detained, transferred to prisons on new criminal convictions, and monitored under community surveillance programs are also changing to …

Strategies For Reducing Occupational Stress On Cabin Crewmembers In The Airline Industry, Wendy N. Lindsey

Walden Dissertations and Doctoral Studies

Occupational stress threatens airline cabin crew and passengers’ health and safety. Airline leaders who lack strategies to address occupational stress may experience adverse impacts on cabin crew health, organizational efficiency, and overall aviation safety. Grounded in the job demands-resources theory, the purpose of this single case study was to explore strategies that upper-level airline leaders used to reduce occupational stress on cabin crewmembers. The participants were five upper-level airline leaders with more than 10 years of airline experience. Data were collected via semistructured interviews, organizational documents, and company records. Three themes emerged from Yin’s five-step approach: inflight training for generating …

Impact Of Healthcare Providers’ Perception On Telehealth Implementation, Misty Leann Cantrell

Walden Dissertations and Doctoral Studies

Telehealth has been proven to have a significant impact on patient outcomes; however, the use of telehealth in both rural and urban areas is sporadic and inconsistent. Although researchers have investigated this issue, there is little literature on the understanding of the impact healthcare provider (HCP) perception plays in this sporadic usage. The purpose of this quantitative research study was to understand how perception and behavioral intention of HCPs impacted the use of telehealth in rural and urban areas. The unified theory of acceptance and technology (UTAUT) was used to structure this research to facilitate determining the correlation between perception …

Experimental Elucidation Of The Life Cycle Of Drepanocephalus Spathans (Digenea: Echinostomatidae) With Notes On The Morphological Plasticity Of D. Spathans In The United States, Neely R. Alberson, Thomas G. Rosser, Tommy King, Ethan T. Woodyard, Lester Khoo, Wes A. Baumgartner, Daviod J. Wise, Linda M. Pote, Fred L. Cunningham, Matt J. Griffin

United States Department of Agriculture Wildlife Services: Staff Publications

The echinostomatid Drepanocephalus spathans (syn. Drepanocephalus auritus) parasitizes the doublecrested cormorant Phalacrocorax auritus. In North America, the marsh rams-horn snail Planorbella trivolvis and ghost rams-horn snail Biomphalaria havanensis serve as snail intermediate hosts, both of which inhabit catfish aquaculture ponds in the southeastern United States. Studies have demonstrated D. spathans exposure can be lethal to juvenile channel catfish Ictalurus punctatus. Two studies were undertaken to elucidate the life cycle of D. spathans to establish a developmental time line. In both studies, D. spathans cercariae collected from naturally infected P. trivolvis individuals were used to infect channel catfish …