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The Rider (2022-11-28), Verilu Infante

The Rider Archives

Vol.8 No.13

Hiv And Early Life Stress On Neuroimaging And Risky Behavior, Paola Garcia Egan

Dissertations

This study examined the interactive effects of early life stress (ELS) and HIV on brain morphometry, diffusion-basis-spectrum-imaging (DBSI), risky decision-making, and sex-risk behavior. 122 people with HIV (PWH) and 113 people without HIV (PWoH), free of major psychiatric illness and neurological confounds, were stratified into high (≥ 3 events) vs. low (< 3 events) ELS [PWoH/low ELS (n = 57), PWoH/high ELS (n =56), PWH/low ELS (n = 43), PWH/high ELS (n = 79)] and underwent structural magnetic resonance imaging, DBSI, neuropsychological, and risky-behavior assessment; all PWH were virologically controlled. Compared to PWoH, PWH had smaller orbitofrontal cortex (OFC), parietal lobes, insula, caudate and anterior cingulate. No ELS effects were detected in volumetric measures. Significant interactions were found between HIV serostatus and ELS on the OFC and on cellularity of the inferior fronto-occipital fasciculus after multiple comparisons adjustment. Specifically, PWH/high ELS exhibited significantly smaller OFC and PWoH/high ELS show significantly larger OFC than the other groups. PWoH/high ELS exhibited higher DBSI cellularity (neuroinflammation proxy) of the inferior-occipital-fasciculus compared to PWoH/high ELS. Regardless of HIV status, executive function moderated the relationship between the OFC and sex-risk behavior such that individuals within the sample who performed above average on a measure of executive function and had a larger OFC reported fewer sex partners in past six months than individuals with smaller volumes. No interaction was found between HIV serostatus and ELS on risky behavior measures. Clustering analyses defined ELS subgroups in PWH that were determined by demographic characteristics, duration of infection, recent CD4+ T-cell count, nadir CD4+ T-cell count and high/low ELS.Even in PWH that are virologically controlled, without major current psychiatric comorbidities, there is evidence of a synergistic impact of ELS and HIV on OFC volumes. Higher volumes in the OFC were detrimental when associated with lower executive function scores or advantageous when associated with higher executive function. Findings suggest that ELS is associated with different brain signatures among PWoH and virally suppressed PWH. However, ELS was not directly associated with risky behaviors, and subgroups in PWH were characterized by demographic variables, past substance use and HIV clinical variables.

Long-Term Care In The United States: History, Financing, And Directions For Reform, George A. (Sandy) Mackenzie

Upjohn Press

This book is a concise survey of the development of U.S. long-term care and its financing, with comparisons with other rich countries. It also includes a brief comparative account of the impact of the COVID-19 pandemic in the United States and several other countries. The study finds much that is amiss with American long-term care and proposes three sets of progressively more ambitious reforms.

Genetic And Small-Molecule Modulation Of Stat3 In A Mouse Model Of Crohn's Disease, Prema Robinson, Emily Magness, Kelsey Montoya, Nikita Engineer, Thomas K Eckols, Emma Rodriguez, David J Tweardy

Faculty, Staff and Student Publications

Crohn's disease (CD), is an inflammatory bowel disease that can affect any part of the gastro-intestinal tract (GI) and is associated with an increased risk of gastro-intestinal cancer. In the current study, we determined the role of genetic and small-molecule modulation of STAT3 in a mouse model of CD. STAT3 has 2 isoforms (α, β) which are expressed in most cells in a 4:1 ratio (α: β). STAT3α has pro-inflammatory and anti-apoptotic functions, while STAT3β has contrasting roles. We used an animal model of CD consisting of intrarectal administration of 2,4,6-trinitrobenzene sulfonic acid and examined the severity of CD in …

Crises, Creep, And The Surveillance State, Michal Lavi

Seton Hall Law Review

No abstract provided.

Fear And Trembling While Working In A Pandemic: An Exploratory Meta-Analysis Of Workers’ Covid-19 Distress, William P. Jimenez, Ian M. Katz, Elissa A. Liguori

Psychology Faculty Publications

The global COVID-19 pandemic has disrupted the lives of workers and taken its toll on health and well-being. In line with recent calls for more inductive and abductive occupational health science research, we exploratorily meta-analyzed workers’ COVID-19 distress, defined as psychological and psychosomatic strain contextualized to experiencing the virus and pandemic broadly. We identified many existing COVID-19 distress measures (e.g., Fear of COVID-19 Scale by Ahorsu et al., 2020; Coronavirus Anxiety Scale by Lee, 2020a) and correlates, including demographic variables (viz., gender, marital status, whether worker has children), positive well-being (e.g., quality of life, perceived social support, resilience), negative well-being …

Clinical And Molecular Insights Into Gastrointestinal Dysfunction In Myotonic Dystrophy Types 1 & 2, Janel A M Peterson, Thomas A Cooper

Faculty, Staff and Students Publications

Myotonic dystrophy (DM) is a highly variable, multisystemic disorder that clinically affects one in 8000 individuals. While research has predominantly focused on the symptoms and pathological mechanisms affecting striated muscle and brain, DM patient surveys have identified a high prevalence for gastrointestinal (GI) symptoms amongst affected individuals. Clinical studies have identified chronic and progressive dysfunction of the esophagus, stomach, liver and gallbladder, small and large intestine, and rectum and anal sphincters. Despite the high incidence of GI dysmotility in DM, little is known regarding the pathological mechanisms leading to GI dysfunction. In this review, we summarize results from clinical and …

Memes From Confinement: Disorientation And Hindsight Projection In The Crisis Of Covid-19, David Divita

Pomona Faculty Publications and Research

Memes have been described as textual forms of “(post)modern folklore” (Shifman, 2014: 5). Photos or short videos, they highlight current cultural phenomena, and they spread exponentially through person-to-person sharing on social media platforms. For this article, I created a corpus of memes that circulated in March 2020, during the first weeks after statewide lockdown orders were issued in the U.S. in response to the COVID-19 pandemic. Drawing on Bakthin’s (1981) concept of the chronotope, I analyze a subset of these memes that specifically addressed the experience of time in confinement, illuminating two interrelated trends: the disruption of temporal order in …

Worker Participation In A Time Of Covid: A Case Study Of Occupational Health And Safety Regulation In Ontario, Alan Hall, Eric Tucker

Articles & Book Chapters

This study examines worker voice in the development and implementation of safety plans or protocols for covid-19 prevention among hospital workers, long-term care workers, and education workers in the Canadian province of Ontario. Although Ontario occupational health and safety law and official public health policy appear to recognize the need for active consultation with workers and labour unions, there were limited – and in some cases no – efforts by employers to meaningfully involve workers, worker representatives (reps), or union officials in assessing covid-19 risks and planning protection and prevention measures. The political and legal efforts of workers and unions …

A Two-Layer Network Propagation Model Of Awareness Diffusion And Seir Epidemic, Yurong Song, Yulin Bao, Ruqi Li

Journal of System Simulation

Abstract: In order to understand the transmission characteristics of epidemics similar to COVID-19 (coronavirus disease 2019) with obvious expose period, a two-layer network transmission model considering time-varying factors is proposed to make corresponding predictions and measures. The UAU (unaware-aware-unaware) information transmission model is used to represent the diffusion process of conscious information about epidemic. In the underlying network, the susceptible-exposed-infected- recovered (SEIR) epidemic-like transmission model with latent state is used to describe the epidemic transmission process affected by conscious information. The MMCA (microscopic Markov chain approach) is used to deduce the transmission threshold of epidemics diseases. By analyzing the key …

Factors Associated With Meeting Physical Activity Guidelines During The Covid-19 Pandemic, Natalia I Heredia, Michael Machiorlatti, Belinda M Reininger, Candace Robledo

Faculty, Staff and Student Publications

INTRODUCTION: The COVID-19 pandemic impacted individual physical activity levels. Less is known regarding how factors such as sociodemographic and built environment were associated with physical activity engagement during the pandemic. Understanding these factors is critical to informing future infectious disease mitigation policies that promote, rather than hinder physical activity. The purpose of this study was to assess predictors of physical activity levels during the beginning of the pandemic (April-June 2020), including Stay-at-Home length and orders, neighborhood safety, and sociodemographic characteristics.

METHODS: Data included 517 participants who responded to an anonymous online survey. Physical activity was assessed with a modified Godin …

Factors Associated With Meeting Physical Activity Guidelines During The Covid-19 Pandemic, Natalia I. Heredia, Michael Machiorlatti, Belinda M. Reininger, Candace Robledo

School of Medicine Publications

Introduction: The COVID-19 pandemic impacted individual physical activity levels. Less is known regarding how factors such as sociodemographic and built environment were associated with physical activity engagement during the pandemic. Understanding these factors is critical to informing future infectious disease mitigation policies that promote, rather than hinder physical activity. The purpose of this study was to assess predictors of physical activity levels during the beginning of the pandemic (April-June 2020), including Stay-at-Home length and orders, neighborhood safety, and sociodemographic characteristics.

Methods: Data included 517 participants who responded to an anonymous online survey. Physical activity was assessed with a modified Godin …

Immune Phenotypes That Are Associated With Subsequent Covid-19 Severity Inferred From Post-Recovery Samples, Thomas Liechti, Yaser Iftikhar, Massimo Mangino, Margaret Beddall, Charles W Goss, Jane A O'Halloran, Philip A Mudd, Mario Roederer

2020-Current year OA Pubs

Severe COVID-19 causes profound immune perturbations, but pre-infection immune signatures contributing to severe COVID-19 remain unknown. Genome-wide association studies (GWAS) identified strong associations between severe disease and several chemokine receptors and molecules from the type I interferon pathway. Here, we define immune signatures associated with severe COVID-19 using high-dimensional flow cytometry. We measure the cells of the peripheral immune system from individuals who recovered from mild, moderate, severe or critical COVID-19 and focused only on those immune signatures returning to steady-state. Individuals that suffered from severe COVID-19 show reduced frequencies of T cell, mucosal-associated invariant T cell (MAIT) and dendritic …

The Effectiveness Of A Religious Counseling Program In Reducing Symptoms Of Obsessive-Compulsive Disorder Among Philadelphia University Students فاعلية برنامج إرشادي ديني في خفض أعراض الوسواس القهري لدى طلبة جامعة فيلادلفيا, Sanaa Nasser Khawaldeh

Jordanian Educational Journal

Abstract:

The study seeks to identify the effectiveness of a religious counseling program in reducing symptoms of obsessive compulsive disorder among Philadelphia University students. The study population consisted of all students for the academic year 2018/2019, where the obsessive-compulsive measure was applied as a pre-test on students who have desire to participate in the program, they were (60).The sample was chosen from students who received moderate and high scores on the OCD scale were randomly divided into two groups (experimental and control)(20) students each group.To demonstrate the statistical differences significance between means (MANCOVA) was used, also (t) test was used …

Framing Of Covid-19 In Newspapers: A Perspective From The Us-Mexico Border, Rifat Afrin, Ahasan Harun, Gayle Prybutok, Victor Prybutok

Information Systems Faculty Publications

The degree to which the media report a health emergency affects the seriousness with which the people respond to combat the health crisis. Engagement from local newspapers in the US has received scant scrutiny, even though there is a sizable body of scholarship on the analysis of COVID-19 news. We fill this void by focusing on the Rio Grande Valley area of the US-Mexico border. To understand the differences, we compared such local news coverage with the coverage of a national news outlet. After collecting the relevant news articles, we used sentiment analysis, rapid automatic keyword extraction (RAKE), and co-occurrence …

A Retrospective Study Of Children With Multisystemi Nflammatory Syndrome And Intravenous Immunoglobulin Treatment, Balleda Lokeswari, Kolla Sravani, Thimmapuram Chandrasekhara Reddy

Journal of Medicine in Scientific Research

Objectives To compare the outcomes of multisystem inflammatory syndrome in children (MIS-C) associated with severe acute respiratory syndrome coronavirus 2 infection treated with intravenous immunoglobulin (IVIG) and without IVIG. Patients and methods A retrospective observational study was conducted over a period of 2 months. We enrolled all children (1–18 years, both sexes) who presented with coronavirus disease 2019-associated MIS-C (as per WHO definition). The patient classification and treatment were done as per the PGIMER Chandigarh protocol (IVIG along with corticosteroids and aspirin was given in all cases with moderate, severe disease, and Kawasaki disease phenotype). Mild cases did not receive …

Characteristic Clinical Features Of Rheumatic Patients With Covid-19 Infection In Mataria Teaching Hospital, Wael Mahmoud Hossameldin, Wessam Eissa Hamed

Journal of Medicine in Scientific Research

Objective The patients who have rheumatic diseases and have coronavirus disease 2019 (COVID-19) infection, their clinical features have not been reported. This study aims to identify the characteristic clinical features of COVID-19 in patients with rheumatic diseases admitted either inside or outside the ICU and present data to handle these conditions in clinical practice. Patients and methods We conducted a retrospective study, including data about the sex, age, laboratory and radiographic findings, clinical symptoms and signs, ICU admission, and drug history, from 180 patients having COVID-19 infection, and includes 61 patients having in combination of rheumatic diseases, in the period …

Coronavirus Disease 2019 And Diabetes Mellitus, Ashraf M. A. Eid, Ehab K. El Melegy, El-Saied A. Shahin, Khaled S. A. Elkelany, Mariam A. Fouad

Journal of Medicine in Scientific Research

Introduction In late 2019, a new virus severe acute respiratory syndrome coronavirus-2, which causes a new serious disease called coronavirus disease 2019 (COVID-19), spread quickly all over the world. Many complications of diabetes mellitus (DM) such as microvascular and macrovascular complications increase the risk for COVID-19-related severity and mortality. Objective To assess the effect of DM on outcome and severity of COVID-19. Patients and methods This work was a retrospective observation that included confirmed COVID-19-infected patients (PCR positive for COVID-19) who were admitted to Shebin El-Kom Teaching Hospital, Menoufia, Egypt, from March 2021 to March 2022. Laboratory investigations such as …

Esophageal Ulcer After Band Ligation Of Esophageal Varices, Ashraf M. A. Eid, El-Saied A. Shahin, Feisal Goda, Mariam A. Fouad

Journal of Medicine in Scientific Research

Introduction Band ligation plays an important role in the management of esophageal varices (EV), but banding ligation carries a risk of band slippage, postbanding esophageal ulcer formation, and postbanding bleeding. Aim The predisposing factors and frequency of esophageal ulcer after banding ligation of EV were assessed. Patients and methods A total of 130 cirrhotic patients with EV were subjected to therapeutic or prophylactic banding ligation, and then the patients were observed for 14 days for detection of incidence of esophageal ulcer bleeding after postbanding ligation. This was a prospective study done to compare the cirrhotic patients without endoscopic variceal ligation …

Clinical Profile And Outcomes Of Children With Covid-19: A Single-Center Prospective Study, Alok Raina, Pooja Bharti, Preeti Sharma, Sonam Chalotra

Journal of Medicine in Scientific Research

Objective The aim was to study the epidemiology, clinical profile, and outcomes of children with coronavirus disease-2019 (COVID-19) admitted in our hospital. Methods This prospective study was conducted at the tertiary care dedicated hospital of COVID-19 in North India between April 1, 2021 and June 30, 2021. A total of 36 children less than or equal to 18 years of age who tested positive for SARS-CoV-2 by RT-PCR from nasopharyngeal swab were enrolled. The details pertaining to age, sex, clinical symptoms, severity of the disease, radiography abnormalities, and laboratory investigations were recorded. The outcomes were mortality, discharged patients, and complications. …

We Are ... Marshall, November 23, 2022, Office Of Marshall University Communications

We Are ... Marshall: the Newsletter for Marshall University 1999-2023

No abstract provided.

Law In The Service Of Misinformation: How Anti-Vaccine Groups Use The Law To Help Spin A False Narrative, Dorit R. Reiss, Viridiana Ordonez

Northwestern Journal of Law & Social Policy

Social movements use legal tools to create narratives. Those narratives support social agendas which certain movements leverage to mislead their followers and potential followers. In this Article, we examine one influential anti-vaccine organization, the Informed Consent Action Network (ICAN), that uses its far-reaching platform to create false narratives around legal action. Again and again, this anti-vaccine group misrepresented both the legal and the factual meanings of court decisions, settlements, and other legal actions to create a narrative to galvanize its followers and influence newcomers. ICAN filed lawsuits that make anti-vaccine arguments—even when the legal framework did not fit doing so—and …

The Antimicrobial Resistance Crisis Needs Action Now, Nonia Pariente

Research on Antimicrobial Resistance

Antimicrobial resistance is a global problem of increasing proportions that we cannot afford to look away from. This World Antimicrobial Awareness Week, we shine a light on the crisis and ways we can all help to address it.

Pandemic Fatigue Impedes Mitigation Of Covid-19 In Hong Kong, Zhanwei Du, Lin Wang, Songwei Shan, Dickson Lam, Tim K. Tsang, Jingyi Xiao, Huizhi Gao, Bingyi Yang, Sheikh Taslim Ali, Sen Pei, Isaac Chun-Hai Fung, Eric H. Y. Lau, Qiuyan Liao, Peng Wu, Lauren Ancel Meyers, Gabriel M. Leung, Benjamin Cowling

Biostatistics, Epidemiology & Environmental Health Sciences: Faculty Publications

Hong Kong has implemented stringent public health and social measures (PHSMs) to curb each of the four COVID-19 epidemic waves since January 2020. The third wave between July and September 2020 was brought under control within 2 m, while the fourth wave starting from the end of October 2020 has taken longer to bring under control and lasted at least 5 mo. Here, we report the pandemic fatigue as one of the potential reasons for the reduced impact of PHSMs on transmission in the fourth wave. We contacted either 500 or 1,000 local residents through weekly random-digit dialing of landlines …

Effects Of Substance Use Disorder On Oxidative And Antioxidative Stress Markers: A Systematic Review And Meta-Analysis, Thiago Wendt Viola, Rodrigo Orso, Luisa Fossati Florian, Miguel Gomes Garcia, Marco Giovanni Signor Gomes, Eduarda Mascarenhas Mardini, João Paulo Ottolia Niederauer, Aline Zaparte, Rodrigo Grassi-Oliveira

School of Medicine Faculty Publications

Recently, it has been suggested that central and peripheral toxicities identified in persons with substance use disorder (SUD) could be partially associated with an imbalance in reactive oxygen species and antioxidant defenses. We conducted a systematic review and meta-analysis to investigate whether SUD is associated with oxidative stress and to identify biomarkers possibly more affected by this condition. We have included studies that analysed oxidant and antioxidant markers in individuals with SUD caused by stimulants, alcohol, nicotine, opioids, and others (cannabis, inhalants, and polysubstance use). Our analysis showed that persons with SUD show higher oxidant markers and lower antioxidant markers …

Danio Rerio: A Past, Present, And Future Hallmark For Immunological Studies, Michael Solomon Chembars Jr.

Senior Honors Theses

An emerging species that is slowly gaining reputation as a common model organism is Danio rerio. Due to its similarities to our own immune response and its general ease of use, hundreds of studies have been conducted which have increased our understanding of how chemicals or pathogens can affect both our own health, and the health of the environment.

This study aims to briefly describe a brief history of D. rerio, as well as discuss key experiments that have been performed using D. rerio. A comparison will also be made between the human and zebrafish immune responses, and …

Association Between The Health Belief Model, Exercise, And Nutrition Behaviors During The Covid-19 Pandemic, Keagan Kiely, Bill Mase, Andrew R. Hansen, Jessica S. Schwind

Biostatistics, Epidemiology & Environmental Health Sciences: Faculty Publications

Introduction: The COVID-19 pandemic has affected our nation’s health further than the infection it causes. Physical activity levels and dietary intake have suffered while individuals grapple with the changes in behavior to reduce viral transmission. With unique nuances regarding the access to physical activity and nutrition during the pandemic, the constructs of Health Belief Model (HBM) may present themselves differently in nutrition and exercise behaviors compared to precautions implemented to reduce viral transmission studied in previous research. The purpose of this study was to investigate the extent of exercise and nutritional behavior change during the COVID-19 pandemic and explain the …

A Novel Voc Breath Tracer Method To Evaluate Indoor Respiratory Exposures In The Near- And Far-Fields; Implications For The Spread Of Respiratory Viruses, Hooman Parhizkar, Mark Fretz, Aurelie Laguerre, Jason Stenson, Richard Corsi, Kevin Van Den Wymelenberg, Elliott T. Gall

Mechanical and Materials Engineering Faculty Publications and Presentations

Background

Several studies suggest that far-field transmission (>6 ft) explains a significant number of COVID-19 superspreading outbreaks.

Objective

Therefore, quantifying the ratio of near- and far-field exposure to emissions from a source is key to better understanding human-to-human airborne infectious disease transmission and associated risks.

Methods

In this study, we used an environmentally-controlled chamber to measure volatile organic compounds (VOCs) released from a healthy participant who consumed breath mints, which contained unique tracer compounds. Tracer measurements were made at 0.76 m (2.5 ft), 1.52 m (5 ft), 2.28 m (7.5 ft) from the participant, as well as in the …

Qualitative Analysis Of A Twitter-Disseminated Survey Reveals New Patient Perspectives On The Impact Of Urinary Tract Infection, Marissa Valentine-King, Lindsey Laytner, Casey Hines-Munson, Kiara Olmeda, Barbara Trautner, Sheryl Justice, Christina Ching, Larissa Grigoryan

Faculty, Staff and Students Publications

Few studies have harnessed social media to explore patients’ experiences with urinary tract infection (UTI); therefore, we captured UTI experiences and future research suggestions through a Twitter-disseminated survey. The survey posed three qualitative questions inquiring about the impact of UTIs, greatest UTI management hurdle, and research suggestions. We also asked participants to rate how seriously others perceive UTIs and the importance of UTIs in their life (scale: 1–100 (highest)). The study period spanned from January to June 2021. Coding was performed in duplicate, followed by thematic analysis. Of 466 participants from 22 countries, 128 considered their UTIs recurrent (n …

Covid-19 Newsletter (Vol. 146), Center For Disaster Medicine, New York Medical College

COVID-19 Newsletter

No abstract provided.