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The Rider (2022-04-11), Verilu Infante

The Rider Archives

Vol.7 No.25

Community College Students' Sense Of Belonging And Care During Covid-19: A Grounded Theory Study, Lisa A. Dougherty

Theses and Dissertations

The purpose of this qualitative constructivist grounded theory research study was to understand and develop a theory about the experiences of community college students accessing online student support services, during the COVID-19 pandemic, when colleges were forced to close their in-person services. Interviews with seventeen students and a review of 57 email communications from the College yielded the data to construct a theory that extends the theories of sense of belonging and ethic of care to virtual student services – the Virtual Caring Campus Theory.

In the absence of a physical campus, colleges can create a virtual caring campus by …

Role Of Drosophila In Human Disease Research 2.0, Masamitsu Yamaguchi, Shinya Yamamoto

Duncan NRI Faculty and Staff Publications

The fruit fly Drosophila melanogaster is a highly tractable animal model to study various human diseases [1]. Many biological pathways are highly conserved between humans and flies, and nearly 85% of human disease-causing genes have homologs in Drosophila. Drosophila has a relatively short life span and produces a large number of progenies, allowing researchers to perform rapid experiments that can easily be reproduced, allowing reliable statistical analyses of biological data. In addition, there are fewer ethical concerns when using Drosophila for biomedical research compared to mammalian models. Importantly, sophisticated genetic experiments can be designed to answer complicated …

Sex Ratios And The City: Is Parental Corticosterone A Mediator Of The Relationship Between Urbanization And Offspring Sex Allocation?, Denyelle Kilgour

Master of Science in Integrative Biology Theses

The Trivers-Willard hypothesis states that mothers can adjust their offspring sex ratios according to their own condition and the environmental conditions they face during breeding. Past tests of this hypothesis in avian species have focused on how natural variation shapes sex allocation trade-offs. However, urbanization also influences individual condition and presents animals with novel challenges in optimizing their brood sex ratio. One likely mediator of the relationship between environmental conditions, parental condition, and sex ratios is corticosterone (CORT), the primary glucocorticoid in birds. However, no research has examined the links between urbanization, individual condition, CORT, and adaptive sex allocation within …

Characterisation Of Drug-Resistant Mycobacterium Tuberculosis Mutations And Transmission In Pakistan, Gary Napier, Anwar Sheed Khan, Abdul Jabbar, Muhammad Tahir Khan, Sajid Ali, Muhammad Qasim, Noor Mohammad, Rumina Hasan, Zahra Hasan, Susana Campino

Department of Pathology and Laboratory Medicine

Tuberculosis, caused by Mycobacterium tuberculosis, is a high-burden disease in Pakistan, with multi-drug (MDR) and extensive-drug (XDR) resistance, complicating infection control. Whole genome sequencing (WGS) of M. tuberculosis is being used to infer lineages (strain-types), drug resistance mutations, and transmission patterns-all informing infection control and clinical decision making. Here we analyse WGS data on 535 M. tuberculosis isolates sourced across Pakistan between years 2003 and 2020, to understand the circulating strain-types and mutations related to 12 anti-TB drugs, as well as identify transmission clusters. Most isolates belonged to lineage 3 (n = 397; 74.2%) strain-types, and were MDR (n = …

Opportunities For Penicillin Allergy Evaluation In Dental Clinics, Amanda Vivo, Michael J. Durkin, Iboula Kale, Taylor Boyer, Margaret A. Fitzpatrick, Charlesnika T. Evans, Marianne M. Jurasic, Gretchen Gibson, Katie J. Suda

Open Access Publications

No abstract provided.

2022-04-10_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated twice a week on Mondays and Thursdays.

Syndromic Surveillance System data is obtained from approximately 216 facilities participating in syndromic surveillance (139 Emergency Departments (ED), 77 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, …

The Efficacy Of Low-Dose Aspirin In Pregnancy Among Women In Malaria-Endemic Countries, Melissa Bauserman, Sequoia I Leuba, Jennifer Hemingway-Foday, Tracy L Nolen, Janet Moore, Elizabeth M Mcclure, Adrien Lokangaka, Antoinette Tsehfu, Jackie Patterson, Edward A Liechty, Fabian Esamai, Waldemar A Carlo, Elwyn Chomba, Robert L Goldenberg, Sarah Saleem, Saleem Jessani, Marion Koso-Thomas, Matthew Hoffman, Richard Derman, Steven R Meshnick, Carl L Bose

Department of Medicine Faculty Papers

Background: Low dose aspirin (LDA) is an effective strategy to reduce preterm birth. However, LDA might have differential effects globally, based on the etiology of preterm birth. In some regions, malaria in pregnancy could be an important modifier of LDA on birth outcomes and anemia.

Methods: This is a sub-study of the ASPIRIN trial, a multi-national, randomized, placebo controlled trial evaluating LDA effect on preterm birth. We enrolled a convenience sample of women in the ASPIRIN trial from the Democratic Republic of Congo (DRC), Kenya and Zambia. We used quantitative polymerase chain reaction to detect malaria. We calculated crude prevalence …

Evidence-Based Best Practice Toolkit For Competency-Based Orientation In Integrating An Adult Pneumococcal Protocol To Improve Vaccine Rate: A Program Evaluation Review, Magda Angel Cifuentes

Student Scholarly Projects

Practice Problem: Low pneumococcal vaccine uptake among high-risk adults is partly due to underutilized or lack of nurse-driven vaccine protocols, limited understanding of vaccine intervals and indications by nurses, and lack of proper training. Currently, physician-driven orders are the only avenue for high-risk adults to obtain this vaccine in ambulatory sites.

PICOT: In adults 65 years or older within an ambulatory setting, does the use of an adult pneumococcal vaccine protocol, compared to a physician order (no vaccine protocol) impact the rate of vaccination over 2 months?

Evidence: Utilization of two or more interventions provided higher immunization rates. …

The Efficacy Of Low-Dose Aspirin In Pregnancy Among Women In Malaria-Endemic Countries, Melissa Bauserman, Sequoia I. Leuba, Jennifer Hemingway-Foday, Tracy L. Nolen, Janet Moore, Elizabeth M. Mcclure, Adrien Lokangaka, Antoinette Tsehfu, Sarah Saleem, Saleem Jessani

Community Health Sciences

Background: Low dose aspirin (LDA) is an effective strategy to reduce preterm birth. However, LDA might have differential effects globally, based on the etiology of preterm birth. In some regions, malaria in pregnancy could be an important modifier of LDA on birth outcomes and anemia.
Methods: This is a sub-study of the ASPIRIN trial, a multi-national, randomized, placebo controlled trial evaluating LDA effect on preterm birth. We enrolled a convenience sample of women in the ASPIRIN trial from the Democratic Republic of Congo (DRC), Kenya and Zambia. We used quantitative polymerase chain reaction to detect malaria. We calculated crude prevalence …

The Prevalence Of Trauma In The Dunning Cemetery Population (1849 - 1861), Sofia Ponce

Undergraduate Research and Engagement Symposium

Bone fractures are extremely common, whether they come from high-energy or localized force. They are often found in skeletal remains from past populations. Examining fractures of past populations can give insight into their lives, the conditions of their environment, and interpersonal violence. This study examines fractures noted in the Chicago Dunning Poorhouse skeletal population, which has been dated from 1849 to 1861. In total, 120 individuals were excavated at the archeological site and 14 individuals appeared to display evidence of bone fractures from trauma. The frequency, location, and time of fractures will be analyzed and compared to similar archeological populations.

Pain Management In The Right Iliac Fossa During The Covid-19 Pandemic, Daniel Ovidiu Costea, Lucian Serbanescu, Diana Badiu, Valeriu Ardeleanu, Cristian Mihai Branescu, Anca Zgura, Andreea Cristina Costea

Journal of Mind and Medical Sciences

Abdominal pain in the right iliac fossa in women may be caused by a complicated ovarian cyst, adnexitis, and appendicitis. The paper analyses the characteristics of patients with right iliac fossa pain admitted during the Covid-19 pandemic. A retrospective analysis on 25 cases with abdominal pain in the right iliac fossa admitted to “St. Apostol Andrei” Emergency County Clinical Hospital Constanta, Romania between March 2020 and March 2021 was performed. In 52% of the cases, the symptomatology remitted with antispasmodics, 4 (16%) patients had cystic torsion and right adnexectomy (group A, without adnexa), 6 (24%) patients had ruptured cysts and …

The Obstetrical Management Of Hiv-Positive Pregnancy, Mihai George Loghin, Petre Gabriel Gorescki, Romina Marina Sima, Liana Pleș, Daniela Gabriela Balan, Ioana Paunica, Oana Denisa Bălălău

Journal of Mind and Medical Sciences

The human immunodeficiency virus (HIV) infection is a real public health problem in both developing and developed countries. HIV infection has not been treated efficiently for a long time, with HIV-positive women at increased risk of transmitting the infection to their newborns. Without the appropriate treatment, the evolution of the infection is relatively fast. Due to the antiretroviral treatment, the progression of the disease is blocked during the period of asymptomatic infection, and the risk of neonatal transmission is very low. HIV-positive patients undergoing antiretroviral therapy develop undetectable viremia and, in such situations, patients no longer have a risk of …

Anxiety Sensitivity, Uncertainty And Recursive Thinking: A Continuum On Cyberchondria Conditions During The Covid Outbreak, Carmela Mento, Maria Catena Silvestri, Pilar Amezaga, Maria Anna Muscatello, Valentina Romeo, Antonio Bruno, Clemente Cedro

Journal of Mind and Medical Sciences

Background. Cyberchondria is a term used to refer to excessive surfing the web looking for health care information, excessive checking behavior being related to health-related anxiety. This period of quarantine for the Covid-19 pandemic is increasing the pathological use of the internet, and the excessive surfing the web looking for health care information. Another dimension related to the Covid-19 outbreak refers to uncertainty intolerance, for this reason being necessary for the healthcare professionals to provide clear and linear information. Aim. The aim of this review is to identify the psychological correlations connected to cyberchondria in the quarantine period. Methods. Following …

Laboratory Findings In Covid-19 - Alterations Of Hematological, Immunological, Biochemical, Hormonal And Other Lab Panels: A Narrative Review, Yousef Rasmi, Lucas Paulo Jacinto Saavedra, Matei-Alexandru Cozma, Heba El-Nashar, Shaza Aly, Nouran Fahmy, Omayma Eldahshan, Mohamed El-Shazly, Elena Codruța Dobrică, Hamed Kord-Varkaneh, Camelia Cristina Diaconu, Mihnea Alexandru Găman

Journal of Mind and Medical Sciences

Up to the present date, according to the official reports of the World Health Organization (WHO), 205,338,159 patients have been confirmed with the coronavirus disease (COVID-19) and 4,333,094 have died as a consequence of this infectious disorder. The majority of COVID-19 patients will develop hematological, biochemical, immunological, hormonal and other complex alterations of their laboratory data which may be diagnosed using different biomarkers. In this paper, we review the alterations of the hematology, immunology, biochemistry, hormonal and other laboratory panels discovered in the subjects diagnosed with SARS-CoV-2 infection, based on the available data in the literature.

Conference Report: Biocuration 2021 Virtual Conference., Federica Quaglia, Rama Balakrishnan, Susan M. Bello, Nicole Vasilevsky

Faculty Research 2022

The International Society for Biocuration (ISB) aims to promote the field of biocuration and provide a community forum for information exchange and networking. Over the past 14 years, the ISB has hosted annual international conferences, entirely dedicated to the field of biocuration, that rotate between regions across the world. These meetings bring together biocurators from various roles, including database curators, bioinformaticians, ontology developers and students. Due to the ongoing global pandemic, the 14th Annual ISB Biocuration Conference (ISB2021) was held virtually in the form of four sessions and one workshop over the course of the year. Each of the four …

Protocol For A Cluster Randomised Controlled Trial Of Secondary Distribution Of Hepatitis C Self-Testing Within The Context Of A House-To-House Hepatitis C Micro-Elimination Programme In Karachi, Pakistan, Sonjelle Shilton, Dania Ali, Alyia Hasnain, Adeel Abid, Jessica Markby, Muhammad S. Jamil, Niklas Luhmann, Pamela Nabeta, Stefano Ongarello, Saeed Hamid

Medical College Documents

Background: Globally, just 21% of the estimated 58 million people living with hepatitis C virus (HCV) know their status. Thus, there is considerable need to scale-up HCV testing if the World Health Organization (WHO) 2030 hepatitis elimination goals are to be achieved. HCV self-testing may assist with this; however, there are currently no data on the real-world impact of HCV self-testing. With an estimated 5% of the general population living with HCV, Pakistan has the second highest HCV burden in the world. This study aims to evaluate the acceptability and impact of home delivery of HCV self-testing for secondary distribution …

Central Line Associated Blood Stream Infection Prevention With Use Of Disinfection Caps: A Scoping Review, Marianne E. Person, Jessica Biggs, Elizabeth Ross, Margaret Harvey Phd, Aprn, Acnp-Bc, Chfn

Doctor of Nursing Practice Projects

Purpose/Background Central lines provide lifesaving uses, but they also place the patient at risk for central line associated blood stream infections (CLABSI). Catheter location, length of stay, handwashing, dressing changes, and disinfection of ports before use are all factors to prevent CLABSIs, yet sometimes these measures are not enough. Disinfecting caps are another way to decrease central line infection, however not all hospitals use this method. This scoping review aims to compare CLABSI rates with and without the use of disinfecting caps for the duration of central line use in intensive care patients.

Methods From August 2019 to September 2021, …

Impact Of Spontaneous Breathing Trials On Reducing Ventilator-Associated Pneumonia In Adult Intubated Patients: A Scoping Review, Jireh R. Johnson Bsn, Rn, Hamzha Aysheh Bsn, Rn, Keianna Luckett Bsn, Rn, Margaret Harvey Phd, Aprn, Acnp-Bc, Chfn

Doctor of Nursing Practice Projects

Purpose/Background For ventilated patients in the intensive care unit, ventilator-associated pneumonia (VAP) is a major source of morbidity. It is difficult to diagnose due to many of the diagnostic criteria being subjective, its clinical signs that are broad, and its association with various respiratory disorders. Hospitals have developed varying ventilator bundles in expectation to prevent the incidence of Ventilator-associate pneumonia. We performed scoping review to determine the impact of spontaneous breathing trials (SBT) on reducing VAP.

Methods From August to November of 2021, using the MEDLINE, ScienceDirect, and Scopus databases and MeSH search terms, we identified over 20,000 articles containing …

Envisioning Future Urinary Tract Infection Diagnostics, Robin Patel, Christopher R Polage, Jennifer Dien Bard, Larissa May, Francesca M Lee, Valeria Fabre, Mary K Hayden, Sarah D B Doernberg, David A Haake, Barbara W Trautner, Larissa Grigoryan, Ephraim L Tsalik, Kimberly E Hanson

Faculty, Staff and Students Publications

Urinary tract infections (UTIs) are among the most common bacterial infections in the United States and are a major driver of antibiotic use, both appropriate and inappropriate, across healthcare settings. Novel UTI diagnostics are a strategy that might enable better UTI treatment. Members of the Antibacterial Resistance Leadership Group Laboratory Center and the Infectious Diseases Society of America Diagnostics Committee convened to envision ideal future UTI diagnostics, with a view towards improving delivery of healthcare, patient outcomes and experiences, and antibiotic use, addressing which types of UTI diagnostics are needed and how companies might approach development of novel UTI diagnostics.

Medical School Watercooler Newsletter - April 8, 2022, Lindsey Lyle

Watercooler Newsletter

This is the April 8, 2022 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents include:

• Certification program advances life-saving education in obstetrics care
• COM Faculty and Staff Appreciation Day set for April 14
• Pathology seminar to focus on potential therapy for common liver cancer
• New research uses AI to potentially reduce hospital readmissions for children
• Meet a Med Student: Ian Thompson
• Faculty Spotlight: Glen Borchert, Ph.D.
• All alumni classes invited to The Hope Farm during reunion weekend
• Resident and Fellow Scholarship Exposition abstracts due April 18
• Basic Medical Sciences Elevator Pitch Symposium setfor April 14

Determination Of The Level Of Cd4cd69 T Cells In Hemodialysis Patients, Ahmed A. A. Megeed, Azza A. I. Elmenyawi, Mohamed Salah, Nehad R. Ibrahim

Journal of Medicine in Scientific Research

Introduction The CD4 helper T cell is responsible for humoral, cellular immunity, and inflammation. CD69 may be a sensitive marker indicating that the CD4 T cell is activated. The aim of this study is to determine CD4CD69 T cells for estimating the activation of CD4 T cells and to monitor hemodialysis (HD) outcome. Participants and methods Sixty-two HD patients and 50 controls were enrolled in our study. CD3, CD4, CD3CD69, and CD4CD69 T cell percentages were assessed by flow cytometry. Transferrin was determined using ELISA. Results The lymphocyte count, the CD3 T cell percentage and CD4 T cell percentage were …

Modeling The Extended Low And Sudden High Periods Of Activity In Infectious Diseases, Dana Strong

Student Research Symposium

This research explores how the aggregation of individuals during disease spread may, in conjunction with noise, explain how some diseases’ trajectories spend some time at low numbers after which there is a sudden outbreak.

Consideration Of Sex And Gender In Alzheimer’S Disease And Related Disorders From A Global Perspective, Michelle M. Mielke, Neelum T. Aggarwal, Clara Vila-Castelar, Puja Agarwal, Eider M. Arenaza-Urquijo, Benjamin Brett, Anna Brugulat-Serrat, Lyndsey E. Dubose, Willem S. Eikelboom, Jason Flatt, Nancy S. Foldi, Sanne Franzen, Paola Gilsanz, Wei Li, Alison J. Mcmanus, Debora Melo Van Lent, Sadaf Arefi Milan, Elizabeth C. Shaaban, Shana D. Stites, Erin Sundermann, Vidyani Suryadevara, Jean-Francoise Trani, Arlener D. Turner, Jet M. J. Vonk, Yakeel T. Quiroz, Ganesh M. Babulal

Social and Behavioral Health Faculty Research

Sex or gender differences in the risk of Alzheimer’s disease and related dementias (ADRD) differ by world region, suggesting that there are potentially modifiable risk factors for intervention. However, few epidemiological or clinical ADRD studies examine sex differences; even fewer evaluate gender in the context of ADRD risk. The goals of this perspective are to: (1) provide definitions of gender, biologic sex, and sexual orientation, and the limitations of examining these as binary variables; (2) provide an overview of what is known with regard to sex and gender differences in the risk, prevention, and diagnosis of ADRD; and (3) discuss …

Highlight On Some Immune Disorders In Chronic Kidney Disease, Ahmed A. Abdel Megeed, Ahmed H. Elthakaby, Azza A. I. Elmenyawi, Nehad R. Ibrahim

Journal of Medicine in Scientific Research

Introduction Chronic inflammation and immune inadequacy are present in chronic kidney disease (CKD) patients. T-helper type 17 (Th17) cells give rise to interleukin (IL)-17, IL-22, and IL-23, cause neutrophils to drive to sites of infection, and enhance moderate immune reactions to microbes outside the cells. They are responsible for autoimmune diseases. Regulatory T (Treg) cells secrete anti-inflammatory cytokines IL-10 and transforming growth factor beta and suppress immune reactions to preserve immune homeostasis. The decreased count or disability of Treg leads to immune dysregulation. Endoplasmic reticulum stress (ERS) leads to unfolded protein response that is stimulated by glucose-regulated protein 78 (GRP78). …

Pro-Inflammatory Diet Pictured In Children With Atopic Dermatitis Or Food Allergy: Nutritional Data Of The Lina Cohort, Olivia Schütte, Larissa Bachmann, Nitin Shivappa Mbbs, Mph, Ph.D., James R. Hébert Scd, Janine F. Felix, Stefan Röder, Ulrich Sack, Michaek Borte, Wieland Kiess, Ana C. Zenclussen, Gabriele I. Stangl

Faculty Publications

Background: Lifestyle and environmental factors are known to contribute to allergic disease development, especially very early in life. However, the link between diet composition and allergic outcomes remains unclear. Methods: In the present population-based cohort study we evaluated the dietary intake of 10-year-old children and analyses were performed with particular focus on atopic dermatitis or food allergy, allergic diseases known to be affected by dietary allergens. Dietary intake was assessed via semi-quantitative food frequency questionnaires. Based on these data, individual nutrient intake as well as children’s Dietary Inflammatory Index (C-DII™) scores were calculated. Information about atopic manifestations during the first …

Exploring Preventive Healthcare In A High-Risk Vulnerable Population, Trisha L Amboree, Jane R Montealegre, Kayo Fujimoto, Osaro Mgbere, Charles Darkoh, Paige Padgett Wermuth

Faculty, Staff and Student Publications

This study describes preventive care behaviors and explores opportunities to deliver preventive sexual healthcare to a high-risk vulnerable population. Data from the National HIV Behavioral Surveillance (NHBS) system high-risk heterosexuals (HET) cycle (2019) in Houston, Texas, was used to describe preventive care utilization and assess the relationship between healthcare utilization and sociodemographic characteristics. More than 47% reported having no usual source of healthcare, and 94.6% reported receiving no non-HIV STI testing in the past 12 months. Additionally, many sociodemographic factors were associated with healthcare utilization and having a usual source of healthcare. Future efforts should be targeted at increasing preventive …

Exploiting 4–1bb Immune Checkpoint To Enhance The Efficacy Of Oncolytic Virotherapy For Diffuse Intrinsic Pontine Gliomas, Virginia Laspidea, Montserrat Puigdelloses, Sara Labiano, Lucía Marrodán, Marc Garcia-Moure, Marta Zalacain, Marisol Gonzalez-Huarriz, Naiara Martínez-Vélez, Iker Ausejo-Mauleon, Daniel De La Nava, Guillermo Herrador-Cañete, Javier Marco-Sanz, Elisabeth Guruceaga, Carlos E De Andrea, María Villalba, Oren Becher, Massimo Squatrito, Verónica Matía, Jaime Gállego Pérez-Larraya, Ana Patiño-García, Sumit Gupta, Candelaria Gomez-Manzano, Juan Fueyo, Marta M Alonso

Faculty, Staff and Student Publications

Diffuse intrinsic pontine gliomas (DIPGs) are aggressive pediatric brain tumors, and patient survival has not changed despite many therapeutic efforts, emphasizing the urgent need for effective treatments. Here, we evaluated the anti-DIPG effect of the oncolytic adenovirus Delta-24-ACT, which was engineered to express the costimulatory ligand 4-1BBL to potentiate the antitumor immune response of the virus. Delta-24-ACT induced the expression of functional 4-1BBL on the membranes of infected DIPG cells, which enhanced the costimulation of CD8+ T lymphocytes. In vivo, Delta-24-ACT treatment of murine DIPG orthotopic tumors significantly improved the survival of treated mice, leading to long-term survivors that developed …

Women's Postpartum And Postnatal Clinic, Savannah Fellows

Student Research Symposium

A Women’s Postpartum and Postnatal Inpatient Clinic in Logan, Ut is carefully designed to promote comfort, healing, and nurturing. Mental health effects of labor and delivery aren’t always immediately apparent to nurses or doctors. Some include baby blues, postpartum depression, and postpartum psychosis. Government resources are often unknown to low-income and homeless societies. The clinic takes care of them after labor and delivery to properly heal, bond with their baby, and feel safe. Aftercare the patients will leave with knowledge of resources and references that’ll help them find the help they need.

Evaluation Of Dape Inhibitors Utilizing The Dape Ninhydrin And Thermal Shift Assays Toward The Discovery Of Novel Antibiotics, Megan Beulke

Undergraduate Research and Engagement Symposium

An ongoing effort continues against the rising tide of antibiotic resistant bacteria, underscoring the urgent need to discover antibiotics with a novel mechanism of action. To this end, we have focused on the inhibition of the bacterial enzyme N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE). Guided by docking with the computational suite Molecular Operating Environment (MOE) and lead molecules obtained through a HiTS (High Throughput Screening) assay, several lead molecules and analogs were identified, synthesized, and optimized by our research group. These potential new inhibitors are tested in our recently described and updated biochemical DapE ninhydrin assay, with IC50 data obtained for inhibitors …