Digital Commons Network^™

Navigating The Cold And Flu Aisle: An Evidence-Based Approach For Nurse Practitioners, Elizabeth Edwards

Student Works

Background: The most common illness know is the common cold. Antibiotics are inappropriate for treating the common cold, but there are many over-the-counter medications available. These over-the-counter medications have not been shown to decrease the length of a cold, though they can ease symptoms. In this paper, we aimed to review the active ingredients in recommended OTC cold remedies for the general population and assess the evidence for their effectiveness. We hope this information will provide NPs with evidence-based strategies to help their patients be better prepared to navigate the cold and flu aisle.

Methods: The US News 2020 …

Innovation Policy And Chronic Emergencies, Robert Burrell, Catherine Kelly

Vanderbilt Journal of Entertainment & Technology Law

The COVID-19 pandemic has thrust the potential role of the state as a driver of scientific innovation onto center stage. Vaccines have been developed and brought to market in a timescale that seemed almost impossible when the crisis first struck. The pivotal nature of government intervention in this crisis has added to calls from academics and policy makers to adopt a more proactive, mission-oriented approach to innovation policy to tackle other key global challenges.

This Article considers the merits of these calls and argues that an important distinction must be drawn between what this Article terms acute and chronic emergencies. …

The Impact Of Covid-19 On The Opioid Epidemic, Hailey Stewart

Undergraduate Honors Theses

The COVID-19 pandemic adversely affected the lives of most Americans. People with Substance Use Disorder (SUD) were particularly vulnerable to the negative effects brought on by the pandemic. This study explored the increase in deaths due to opioid overdose during the pandemic exacerbated by factors such as increased stress, decrease in treatment options due to social distancing requirements and facility closures, social isolation, and an increase in spare time. Access to treatment for opioid use disorder (OUD) was interrupted by the measures meant to mitigate the spread of COVID-19. Through a systematic review of current literature, it was demonstrated that …

Epidemiology And Impacts Of A Leaf Spot Disease In Veratrum Viride (Melanthiaceae), Leeah R. Sutton, Foster Levy

Undergraduate Honors Theses

Fungal phytopathogens can cause disease epidemics in crops, weeds, and
populations of native plants. To investigate the impact of a foliar phytopathogen on the native herbaceous species, Veratrum viride, a demographic and disease assessment was carried out on two high elevation grassy bald populations on Roan Mountain, Tennessee. A leaf spot disease impacted all plants in both populations, causing widespread premature senescence of leaves and stems. Disease severity increased over the course of the growing season. Based on host disease symptoms and fungal conidia morphology, Pseudocercosporella sublineolata was shown to be the causal pathogen. A study of herbarium specimens …

The Contribution Of Alternative Splicing And Post-Transcriptional Mechanisms Toward The Global Control Of Sumo1/2/3 Sumoylation, Myriah Lorraine Acuna

Open Access Theses & Dissertations

Evolutionary pressures have caused eukaryotic cells to develop various response mechanisms to changing environments, particularly stress adaptations that have been inherited over time. SUMOylation, the post-translational conjugation of the Small Ubiquitin-like Modifiers to a lysine residue on target proteins, is well-documented to regulate essential processes within the cell, including nucleocytoplasmic transport, transcription, apoptosis, protein stability, and progression through the cell cycle (1). SUMO protein levels have been reported to increase upon diverse stress states, including viral infection (2), cardiovascular ischemic events (3), temperature shock (4), and cancer (5). However, very little is known about how SUMOylation is regulated within the …

Integration Of Genetic Isothermal Amplification On Low-Cost Hybrid Paper/Polymer Microfluidic Biochips For High Sensitivity Point-Of-Care Disease Diagnosis, Hamed Tavakoli

Open Access Theses & Dissertations

Infectious diseases and cancer have been two main causes of global death and disability, leading to a significant impact on public health and economies globally. Early diagnosis of these diseases can improve prevention, treatment, and prognosis in clinical practice. However, current laboratory diagnostic approaches require expensive and bulky equipment, well-trained personnel, and time-consuming processes, which puts a great challenge to conventional methods to address, especially in resource-limited settings. Microfluidic lab-on-a-chip presents a unique opportunity for various biomedical applications due to multiple advantages such as low reagent consumption, integration, miniaturization, portability, and automation. Since different microfluidic platform substrates have their advantages …

Skin And Soft Tissue Infection, Children's Mercy Kansas City

Clinical Pathways (Formally Known As Clinical Practice Guidelines)

No abstract provided.

Urinary Tract Infection-Cystitis/Pyelonephritis, Children's Mercy Kansas City

Clinical Pathways (Formally Known As Clinical Practice Guidelines)

No abstract provided.

Discovery Of Ojt008 As A Novel Inhibitor Of Mycobacterium Tuberculosis, Collins Chidi Onyenaka

Dissertations (2016-Present)

Despite recent progress in the diagnosis of Tuberculosis (TB), the chemotherapeutic management of TB is still challenging. Mycobacterium tuberculosis (Mtb) is the etiological agent of TB, and TB is classified as the 13th leading cause of death globally [WHO 2021]. 558,000 people were reported to develop multi-drug resistant TB globally [WHO 2020]. Our research focuses on targeting Methionine Aminopeptidase (MetAP), an essential protein for the viability of Mtb. MetAP is a metalloprotease that catalyzes the removal of N-terminal methionine (NME) during translation of protein [Giglione et al., 2003]. This essential role of MetAPs makes this enzyme an auspicious target for …

Preclinical Development Of A Novel Antileishmanial Agent Ojt007: Bioanalytical Assay, In Vitro Studies And Pharmacokinetics, Maria Eugenia Rincon-Nigro

Dissertations (2016-Present)

Current treatments for cutaneous leishmaniasis suffer from toxic side effects, high cost, parenteral administration, and drug resistance. Thus, there is a critical need to develop oral drugs for the treatment of leishmaniasis. OJT007 is a novel class of drug with potent antiproliferative effects against Leishmania Major. The purpose of this project is to conduct preclinical drug development studies for OJT007 including bioanalytical assay development, pre-formulation studies, in vitro hepatic drug metabolism and in vivo pharmacokinetics. A sensitive, specific, and reproducible ultra-high performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated. The separation was achieved on a UPLC BEH …

Factors Affecting Hotel Recommendation: Before The Covid-19 Pandemic And After The Reopening, Boran Kim

UNLV Theses, Dissertations, Professional Papers, and Capstones

During the COVID-19 pandemic, numerous people lost their lives, and a lot of industries were affected. The hospitality industry was especially affected due to social distancing, travel restrictions, and safety issues. During that time, not only did customers' expectations change but their recommendation of hotels to friends and colleagues also changed. The current study used five factors (i.e., cleanliness, location, room, service, and value) to discover which factors were affecting hotel recommendation before the COVID-19 pandemic and after the reopening. This study used secondary data (online surveys) from one of the well-known integrated resorts located in the western United States. …

Mutual Recognition Of Covid-19 Vaccine To Restore Normal Social Activities And Redistribute Vaccines For The Next Stage Of The Pandemic, Chenyu Sun, Scott Lowe, Qin Zhou, John Patrick Nanola Uy

Student Publications

No abstract provided.

Calcium Intake Among Parents And Caregivers Of Children With A Milk Allergy Or Intolerance : A Comparative Analysis, Ilana Dubrovsky-Razam

Theses, Dissertations and Culminating Projects

Food allergies have become a global epidemic, affecting over 10% of the general population and 8% of children worldwide. Eliminating or limiting a food group from the diet can have adverse effects on micronutrient consumption. Milk allergies, for instance, can influence the amount of calcium consumed in the diet, particularly when limiting or excluding milk/milk-containing products from the diet. As milk products tend to be a primary source of dietary calcium, a milk allergy can serve as a barrier to meeting daily calcium needs.

Previous literature has analyzed the influence parents and caregivers have on their children’s diet, however, there …

Developing Implantable Hydrogel-Based Sensors To Measure Biomarkers In Synovial Joint Fluid Using Plain Radiography, Uthpala N. Wijayaratna

All Dissertations

The goal of my dissertation research is to develop implantable sensors that attach to prosthesis prior to implantation and measures biomarkers of infection in joint fluid in order to detect, monitor, and study infection using plain radiography. Joint replacement surgeries are common procedures improving the mobility and lives of millions of people worldwide. Although the surgeries are generally successful, about 1% of prosthetic hips become infected. If the infections are not detected and treated promptly with antibiotics and surgical debridement, device removal is almost always required to treat the infections. Therefore, it’s important to detect post-surgery infections early and monitor …

Groundwork For The Development Of Gpu Enabled Group Testing Regression Models, Paul Cubre

All Dissertations

In this dissertation, we develop novel techniques that allow for the regression analysis of data emerging from group testing processes and set the groundwork for graphic processing units (GPU) enabled implementations. Group testing primarily occurs in clinical laboratories, where it is used to quickly and cheaply diagnose patients. Typically, group testing tests a pooled specimen--several specimens combined into one sample--instead of testing individual specimens one-by-one. This method reduces costs by using fewer tests when the disease prevalence is low. Due to recent advances in diagnostic technology, group testing protocols were extended to incorporate multiplex assays, which are diagnostic tests that, …

Porphyromonas Gingivalis, Ethanol, And Chronic Diseases., Nicholas Alan Short

Electronic Theses and Dissertations

This dissertation is an investigation into the relationships among Porphyromonas gingivalis, ethanol, and a series of chronic diseases, focusing primarily on atherosclerosis. It uses evolutionary theory to understand clinical parameters related to chronic disease biology. The initial research question was, "If people who drink a glass of wine each day have a lower risk for atherosclerosis, could one explanation involve antibacterial effects on pathogens associated with causing atherosclerosis, namely, Porphyromonas gingivalis?". This dissertation is divided into four chapters. Chapter One provides the foundational information pertinent to the dissertation. Chapter Two describes an in- vitro experiment aimed at understanding …

The Plague: A Contemporary Lens, Khawaja Ahmed, Delaney Collier, Will Plumb

Student Research

The Plague by Albert Camus bears witness to the town of Oran amidst the spread of the plague from the beginning to the end of the quarantine placed on the town. Although it is a direct comparison to the COVID-19 pandemic, Camus’s themes expressed in his novel resonates with other contemporary worldly issues that may or may not have an explanation. These other contemporary issues include war and the climate crisis. From our 2022 perspective, we have seen the COVID pandemic play out firsthand. We have witnessed from afar the threat of World War III and the current war in …

Characterization Of The Influence Of A Small Molecule Inhibitor On Ras-Related Proteins Interactions, Emilio Duverna

Graduate Theses and Dissertations

The Ras superfamily of small G proteins are involved in cell-signaling processes that, if not regulated, may lead to cell multiplication, apoptosis inhibition, and tumorigenesis. They function as molecular switches, which through GTP/GDP exchange cycle, switch on or off cellular activities. Overexpression and/or hyperactivity of these proteins have been linked to many diseases including various cancers. CDC42, a member of the Rho subfamily of the Ras superfamily of small G proteins, participates in the regulation of many cellular processes including cell adhesion, mitosis, and cytoskeletal rearrangements. CDC42 binds to and activates many effector proteins including CDC42-activated kinase (ACK). Abnormal activities …

Covid-19 Drive-Through Mass Vaccination In Northwest Louisiana, Deborah Gurgel Smith, John Anthony Vanchiere, Michelle Raley, Andrew David Yurochko, Mohammad Alfrad Nobel Bhuiyan, Kevin Sean Murnane, Rona Scott, Jeremy Kamil, Jill Rush-Kolodzey, Martha Whyte, Kenneth Densmore, Maaren Van Diest, Christopher Kevil

Journal of the Louisiana Public Health Association

No abstract provided.

The Role Of Ketamine In The Management Of Chronic Pain, Hugh W. Cline Iii

Physician Assistant Scholarly Project Papers

Chronic pain diagnoses are on the rise amongst people within the United States and thought to be an epidemic. It is estimated to affect millions of patients who have suffered trauma, injury, or complications from surgical procedures. The treatment of chronic pain, defined as pain lasting longer than 3 months, can be complicated. There are no definitive treatment options that have garnered a consensus among medical professionals. Treatment usually involves several medical specialties and pharmacological options. Reliance on the use of multiple pharmacological options can cause patients increased hospitalizations, and a reliance on opioids can potentially cause other illnesses due …

"Beef -- It's Not What's For Dinner": The Implications Of France's Newest Law For The Future Of Labeling Cultured Meat In The European Union, Nick Verderame

North Carolina Journal of International Law

No abstract provided.

Histomonosis In Poultry: A Comprehensive Review, Lesleigh C. Beer, Victor M. Petrone-Garcia, B. Danielle Graham, Billy M. Hargis, Guillermo Tellez-Isaias, Christine N. Vuong

Poultry Science Faculty Publications and Presentations

Histomonas meleagridis, the etiological agent of histomonosis, is a poultry parasite primarily detrimental to turkeys. Characteristic lesions occur in the liver and ceca, with mortalities in turkey flocks often reaching 80–100%. Chickens and other gallinaceous birds can be susceptible but the disease was primarily considered sub-clinical until recent years. Treating and preventing H. meleagridis infection have become more difficult since 2015, when nitarsone was voluntarily removed from the market, leaving the poultry industry with no approved prophylactics, therapeutics, or vaccines to combat histomonosis. Phytogenic compounds evaluated for chemoprophylaxis of histomonosis have varied results with in vitro and in vivo …

Clostridium Perfringens-Induced Necrotic Diseases: An Overview, Ying Fu, Tahrir Jatli Alenezi, Xiaolun Sun

Poultry Science Faculty Publications and Presentations

Clostridium perfringens, a prevalent Gram-positive bacterium, causes necrotic diseases associated with abundant life loss and economic burdens of billions of USD. The mechanism of C. perfringens-induced necrotic diseases remains largely unknown, in part, because of the lack of effective animal models and the presence of a large array of exotoxins and diverse disease manifestations from the skin and deep tissues to the gastrointestinal tract. In the light of the advancement of medical and veterinary research, a large body of knowledge is accumulating on the factors influencing C. perfringens-induced necrotic disease onset, development, and outcomes. Here, we present …

Providencia Rettgeri Infection Compromising Post-Burn Recovery: A Lesson In The Importance Of Follow-Up Care., Mallorie L Huff, Sigrid A. Blome-Eberwein Md

Department of Surgery

Early burn excision and skin grafting have been essential to improving patient outcomes following a burn injury. However, there remain significant barriers to recovery for burn patients, especially in the post-discharge period, as follow-up care is essential to the timely identification of complications. While the infection is a common complication of a post-burn wound,

Taking Health-Risks As A Short-Term Mating Strategy, Alvin Jun Jie Wong

Dissertations and Theses Collection (Open Access)

Diseases pose a recurring, and often indiscriminate threat to the health of individuals. However, there exists a wide range of behavioral responses between individuals when it comes to taking health precautions or undertaking risks in response to this perennial threat, with some responses seeming maladaptive to an individual’s survival. The present study adopts the lens of evolutionary psychology and suggests that taking health risks represent a short-term mating strategy in men, which potentially trades survival for reproductive fitness. Taking health risks is hypothesized to be an honest signal of both good genes and a strong physiological immune system, both of …

Increasing Human Papillomavirus Vaccination Intent And Knowledge Through An Educational Intervention, Angelica E. Musumeci

UNLV Theses, Dissertations, Professional Papers, and Capstones

Human papillomavirus (HPV) is a widely discussed topic in healthcare as it affects patients of all genders and ages who partake in sexual activity. The most significant concern it poses to those at risk is HPV-related cancer. Fortunately, a vaccination exists that targets specific strains associated with these types of cancers. Despite evidence-based research supporting the vaccination’s efficacy and safety, lack of awareness and misinformation diminish the receipt of the vaccine and drive the lack of protection. Thus, educational interventions directed at parents and caregivers, which aims to improve their understanding of HPV and the vaccination’s benefits, is key to …

Neo Development Of The Workplace Environment In Response To Evolutionary Social Changes, Dafne Odette

UNLV Theses, Dissertations, Professional Papers, and Capstones

This study is to identify the needs and wants of remote workers to support their health and well-being in response to evolutionary social changes. Many workers were once tethered to live in the city where their job office resided. Additionally, economic forces have long been a deciding factor in where one lives. The COVID-19 virus of 2020 provided an opportunity for many people to work remotely to control the virus (Latham, Higgins, & Judish, 2020). This has allowed people to retain higher salaries while living in rural areas where the cost of living may be lower. In 2021, some businesses …

County Social Isolation And Opioid Use Disorder Among Older Adults: A Longitudinal Analysis Of Medicare Data, 2013–2018, Tse-Chuan Yang, Carla Shoff, Seulki Kim, Benjamin A. Shaw

Department of Sociology: Faculty Publications

This study aims to fill three knowledge gaps: (1) unclear role of ecological factors in shaping older adults’ risk of opioid use disorder (OUD), (2) a lack of longitudinal perspective in OUD research among older adults, and (3) underexplored racial/ethnic differences in the determinants of OUD in older populations. This study estimates the effects of county-level social isolation, concentrated disadvantage, and income inequality on older adults’ risk of OUD using longitudinal data analysis. We merged the 2013–2018 Medicare population (aged 65+) data to the American Community Survey 5-year county-level estimates to create a person-year dataset (N = 47,291,217 person-years) and …

Childhood Mortality During And After Acute Illness In Africa And South Asia: A Prospective Cohort Study, Childhood Acute Illness And Nutrition (Chain) Network, Abdoulaye Hama Diallo, Abu Sadat Mohammad Sayeem Bin Shahid, Ali Fazal Khan, Ali Faisal Saleem, Benson O. Singa, Blaise Siezanga Gnoumou, Caroline Tigoi, Syed Asad Ali, Zaubina Kazi

Department of Paediatrics and Child Health

Background: Mortality among children with acute illness in low-income and middle-income settings remains unacceptably high and the importance of post-discharge mortality is increasingly recognised. We aimed to explore the epidemiology of deaths among young children with acute illness across sub-Saharan Africa and south Asia to inform the development of interventions and improved guidelines.
Methods: In this prospective cohort study, we enrolled children aged 2-23 months with acute illness, stratified by nutritional status defined by anthropometry (ie, no wasting, moderate wasting, or severe wasting or kwashiorkor), who were admitted to one of nine hospitals in six countries across sub-Saharan Africa and …

Ultrasonography-First Imaging Algorithm For Acute Appendicitis Diagnosis, Steven Lamar Moore

UNLV Theses, Dissertations, Professional Papers, and Capstones

Acute appendicitis (AA) is the most common cause of acute abdominal pain requiring surgery in pediatric, adult, and pregnant patients. Several etiologies are believed to trigger luminal obstruction, which causes mucus and bacteria proliferation, resulting in inflammation and wall tension with subsequent necrosis and rupture of the appendix. Most AA patients present with the primary complaint of abdominal pain, which Murphy first described the characteristic diagnostic sequence seen in approximately 50% of patients as colicky centralized abdominal pain with subsequent vomiting with the migration of pain to the right lower quadrant (RLQ), specifically, the right iliac fossa. The typical AA …