Digital Commons Network^™

Burden, Clinical Characteristics, Risk Factors, And Seasonality Of Adenovirus 40/41 Diarrhea In Children In Eight Low-Resource Settings, Godfrey Guga, Sarah Elwood, Caroline Kimathi, Gagandeep Kang, Margaret N. Kosek, Aldo A M Lima, Pascal O. Bessong, Amidou Samie, Najeeha Talat Iqbal, Zulfiqar Ahmed Bhutta

Department of Biological & Biomedical Sciences

Background: The application of molecular diagnostics has identified enteric group adenovirus serotypes 40 and 41 as important causes of diarrhea in children. However, many aspects of the epidemiology of adenovirus 40/41 diarrhea have not been described.
Methods: We used data from the 8-site Etiology, Risk Factors, and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development Project birth cohort study to describe site- and age-specific incidence, risk factors, clinical characteristics, and seasonality.
Results: The incidence of adenovirus 40/41 diarrhea was substantially higher by quantitative polymerase chain reaction than enzyme immunoassay and peaked at ∼30 episodes …

Medical Students In Karachi And Covid-19: Myths And Facts, Omer Bin Khalid Jamil, Muhammad Muhib, Muhammad Anas Abbal, Amna Muhammed Ahmed, Hafsa Hayat Khan, Nabeela Yar Khan

Department of Surgery Docs

Objectives: COVID-19 pandemic brought mortalities, morbidities, fear, and financial despair among people around the world. As it advanced, misinformation and myths about it caught wildfire, contributing to misbelief among the already shocked population. Medical students are the building blocks of the medical community and can provide a pivotal role in combating COVID-19 misinformation by delivering correct knowledge and awareness to the non-medical population of the country. Hence, it is important to assess their knowledge and perception of COVID-19 myths. Therefore, this study evaluates medical student's knowledge regarding myths and misinformation related to COVID-19 infection and its vaccine. The study also …

Modified Hypoallergenic Filtering Medium For Potential Use In Face Masks: A Systematic Review, Julianne Isabel B. Baldoz, Matthew Raphael C. Duran, Joaquin Ethan S. Hong, Ralph Nathan T. Liong

DLSU Senior High School Research Congress

The COVID-19 pandemic has affected numerous lives and lifestyles of people around the world. In response, governing bodies worldwide have imposed public health protocols such as requiring their residents to wear face masks. To lessen the impacts of COVID-19, it is necessary to strengthen the public’s main protective equipment by having a face mask that can provide better filtration and protection to the user. This research aims to propose an electrospun hypoallergenic bi-layer material composed of a layer of CS/PVA composite and a sheet of PCL that could be used in face masks in the future. The polymers chitosan (CS), …

Assessing And Mapping Of Provincial Risks Of Covid-19 Using Regression-Based Significant Factors In The Philippines, Pauline Dela T. Roca, Jasper Victor Y. Miranda, Shirl Angelee R. Ocampo, Timothy F. Olvina

DLSU Senior High School Research Congress

The Coronavirus disease (COVID-19), a highly contagious fatal viral disease, has infected millions of people and led to substantial losses of human lives worldwide. The Philippines was considered a COVID-19 high-risk country because of the numerous surges, especially in the National Capital Region (NCR) and nearby provinces (‘NCR Plus’ bubble). In line with the UN Sustainable Development Goal 3 on health and well-being, this research was conducted to identify the significant correlates of COVID-19 relative risks and cases in the Philippines in 2020 and 2021, using multiple linear regression model, negative binomial regression model, and principal component analysis. It also …

The Covid-19 Experience: An Intensive Care Nursing Perspective, Adrianna Watson

Dissertations

In December 2019, a new virus reared its head and within a matter of months demanded the attention of the world as health care was challenged to full capacity. Frontline healthcare workers struggled to care for the patient after patient with limited knowledge of pathophysiology, risk of contagion, and resources. As the waves of patients became increasingly critical, the task of everyday human connection and care, as well as extraordinary life-saving measures, fell upon the shoulders of intensive care nurses. Little is known about how these nurses understand their experiences caring for patients with the novel coronavirus, or how their …

Secondary Teacher Perceptions On Lesson Planning And Delivery, Jonathan Watson

Theses and Dissertations

On March 17, 2020, Governor Asa Hutchinson closed all public schools in the state of Arkansas to on-site instruction through March 30 in an effort to contain the spread of the novel Coronavirus. With schools closed, teachers and students made the pivot to online learning. School closures changed the way teachers prepared and delivered lessons. Changes in instruction varied from school building to school building, district to district, and teacher to teacher based on location, available equipment, and individual teacher technological skill sets. This scoping review examines the perceptions of teachers on the effectiveness of lesson planning and content delivery …

The Rhetoric Of Blame: A Rhetorical Framing Analysis Of Othering And Blame In Historical Health Crises, Colin G. Cameron

Master's Theses

The United States’ response to the COVID-19 pandemic was hallmarked by blame rhetoric and fluid social and political expedience. However, the pervasiveness of othering and blame in contemporary pandemic discourse is perhaps consistent with the blame rhetoric of health crises throughout history. Using a rhetorical framing analysis approach, this study aims to explore the various elements of blame rhetoric embedded in newsprint media frames regarding historic infectious disease outbreaks. In doing so, this study investigates three case studies: the San Francisco smallpox outbreak of 1876, the Spanish Flu pandemic of 1918, and the AIDS crisis of the 1980s – 1990s. …

Large Scale Disease Modeling, Walker Mattox

Master's Theses

In this we study large scale disease modeling. After understanding the mechanics behind the SIR disease model in an ODE sense, we will apply this knowledge to model disease spread in more and more increasing advanced cellular automata. Eventually, some of our cellular automata will include long distance travel. From this discrete data, we can then build an SIR model in the PDE sense to display large scale disease spread.

The Use Of Appreciative Inquiry In Identifying Pueblo Core Values, Kristyn N. Yepa

Doctor of Nursing Practice Scholarly Projects

This study used appreciative inquiry to identify core values or concepts essential to the Jemez Pueblo community to inform an evaluation framework used by community strength-based programs in Jemez Pueblo. Key informant interviews and a focus group were conducted in Jemez Pueblo with key program staff and tribal leaders. The audio recordings were transcribed and analyzed using inductive reasoning to identify core values. In addition, grounded theory was used to develop a conceptual model from the themes generated from the analysis. The PICOT question was, "Can the Appreciative Inquiry method help uncover core values of a Pueblo community?"

Nurse Driven Antibiotic Stewardship, Dr. Judy Liesveld R. White

Doctor of Nursing Practice Scholarly Projects

Abstract

Antibiotic use has increased tremendously and has led to antimicrobial resistance. Because it is a growing problem across healthcare systems around the world, healthcare systems and organizations must combat the detrimental effects of inappropriate use of antibiotics. The development of antibiotic stewardship programs is crucial to providing high quality, safe patient care. The work ofthis project intends to form a basic understanding ofa nurses' role as a member of the antibiotic team. Most healthcare systems have operated by a pharmacy driven antibiotic team concept and have just recently included nurses as a missing component to a full functioning team. …

Bromodomains In Human-Immunodeficiency Virus-Associated Neurocognitive Disorders: A Model Of Ferroptosis-Induced Neurodegeneration, Adonis Sfera, Karina G. Thomas, Christina V. Andronescu, Nyla Jafri, Dan O. Sfera, Sarvin Sasannia, Carlos Zapata-Martin Del Campo, Jose E. Campo Maldonado

School of Medicine Publications

Human immunodeficiency virus (HIV)-associated neurocognitive disorders (HAND) comprise a group of illnesses marked by memory and behavioral dysfunction that can occur in up to 50% of HIV patients despite adequate treatment with combination antiretroviral drugs. Iron dyshomeostasis exacerbates HIV-1 infection and plays a major role in Alzheimer’s disease pathogenesis. In addition, persons living with HIV demonstrate a high prevalence of neurodegenerative disorders, indicating that HAND provides a unique opportunity to study ferroptosis in these conditions. Both HIV and combination antiretroviral drugs increase the risk of ferroptosis by augmenting ferritin autophagy at the lysosomal level. As many viruses and their proteins …

Human Macrophages Exhibit Gm-Csf Dependent Restriction Of Mycobacterium Tuberculosis Infection Via Regulating Their Self-Survival, Differentiation And Metabolism, Abhishek Mishra, Vipul K. Singh, Chinnaswamy Jagannath, Margaret Sunitha Selvaraj, Selvakumar Subbian, Blanca I. Restrepo, Marie-Claire Gauduin, Arshad Khan

School of Medicine Publications

GM-CSF is an important cytokine that regulates the proliferation of monocytes/macrophages and its various functions during health and disease. Although growing evidences support the notion that GM-CSF could play a major role in immunity against tuberculosis (TB) infection, the mechanism of GM-CSF mediated protective effect against TB remains largely unknown. Here in this study we examined the secreted levels of GM-CSF by human macrophages from different donors along with the GM-CSF dependent cellular processes that are critical for control of M. tuberculosis infection. While macrophage of different donors varied in their ability to produce GM-CSF, a significant correlation was observed …

Herpes Simplex Encephalitis After Covid-19 Infection, Kurt Knepley, Robert Paschall

Research Day

A gentleman in his 60’s presented to the hospital with dyspnea, fever, and hypoxia. He was diagnosed with Covid-19 pneumonia and treated with BiPAP, oxygen, dexamethasone, enoxaparin, budesonide, and albuterol. His hospital stay lasted 33 days. He was discharged home on oxygen and steroids. He returned to the hospital 3 days later with altered mental status. He was diagnosed with HSV encephalitis and treated with 2 weeks of acyclovir. Although his HSV resolved, he suffered temporal lobe necrosis and lasting neurologic dysfunction.

HSV is the most common cause of encephalitis. HSV encephalitis can occur in a host co-infected with SARS-CoV-2 …

Improving Newborn Hearing Screening Through Collaboration And Communication, Mary Duncan, Marissa Schuh, Shannon Haynes, Anita Taylor, Gwen Moreland, Raleigh Jones, Matthew Bush, Jennifer Shinn

Journal of Early Hearing Detection and Intervention

Purpose: Hearing loss is the number one birth defect among children. There are significant consequences of delayed diagnosis and failure to obtain timely intervention, particularly for a child’s speech and language development. Design and implementation of successful newborn hearing screening (NHS) programs can be challenging. The purpose of this paper is to demonstrate improved efficiency and effectiveness of a large NHS program through the implementation of a team approach engaging both ambulatory and hospital services.

Methodology: A Strengths, Weaknesses, Opportunities, and Threats (SWOT) analysis was used to develop an improved NHS program focused on improving patient care. The SWOT analysis …

Hearing Screening In North Carolina's Nicu And Well-Baby Nurseries: Impact Of Jcih 2019 And Covid-19, Jackson Roush, Shannon Culbertson, Chloe Gratzek, Jane Khin, Alexandra Mccormick, Stephanie Ortega, Madison Rock, Kathryn Sobon, Jenna Van Bosch, Hannah Siburt, Marcia Fort

Journal of Early Hearing Detection and Intervention

Purpose: Over an 18-month period in 2020–2021, the North Carolina Early Hearing Detection and Intervention (EHDI) program in collaboration with the North Carolina Leadership Education in Neurodevelopmental and Related Disabilities (LEND) program conducted a statewide examination of newborn hearing screening practices in North Carolina’s 24 Neonatal Intensive Care Units (NICU) and 86 well-baby nurseries to determine how current protocols and procedures conform to those recommended by the Joint Committee on Infant Hearing (JCIH) in its Year 2019 Position Statement: Principles and Guidelines for Early Hearing Detection and Intervention Programs. The COVID-19 pandemic emerged during the study period and motivated …

Does Manuka Honey Induce Antibiotic Resistant Bacterial Persisters And Viable But Non-Culturable Subpopulations?, Bryn Tennyson

2022 Symposium

Long-term antibiotic use has allowed microbes to develop resistance and cause chronic infectious diseases that were previously treatable. Resistance is phenomenon in which bacteria survive treatment with a concentration of antibiotics that was once lethal. Bacteria resist antibiotic treatment by genetic change or initiating states of dormancy called persisters or Viable but Non-Culturable (VBNCs) cells. These subpopulations of antibiotic resistant persisters and VBNCs increase with exposure to stresses, including antibiotic treatment, and are a major cause of reoccurring infections that result in significant morbidity and mortality. Manuka honey (MH), a well-known alternative broad-spectrum antimicrobial, is a promising treatment for cutaneous …

We Are ... Marshall, May 11, 2022, Office Of Marshall University Communication

We Are ... Marshall: the Newsletter for Marshall University 1999-2023

No abstract provided.

Development And Validation Of High-Resolution Melting Assays For The Detection Of Potentially Virulent Strains Of Escherichia Coli O103 And O121, Frank J. Velez, Joseph M. Bosilevac, Sabine Delannoy, Patrick Fach, Ravinder Nagpal, Prashant Singh

Roman L. Hruska U.S. Meat Animal Research Center: Reports

Virulent strains of Shiga toxin-producing Escherichia coli (STEC) serogroups O103 and O121 are considered adulterants in beef. Two high-resolution melting (HRM) real-time PCR assays were standardized for the specific detection and discrimination of potentially virulent and avirulent strains of E. coli O103 and O121. The O103 HRM assay offered the possibility to distinguish clearly STEC O103:H2 from STEC O103:H25. The two standardized assays were extensively validated using 215 pure culture strains, laboratory inoculated food samples, and naturally contaminated beef (n = 84) and pork (n = 84) enrichments collected from the red meat surveillance program. Both HRM assays showed 100% …

Surviving Future Pandemics: The Economic, Social, And Political Battle Against Climate Change And Infectious Diseases, Dayana Gonzalez

Student Theses 2015-Present

COVID-19 has been a rude wake-up call as it showed us how unprepared we are to fight off infectious diseases. This paper analyzes our political, social, and economic decisions to develop a plan against the future development of infectious diseases. Before the analysis, it is essential to understand that it is natural for infectious diseases to develop and spread; however, climate change has and will continue to exacerbate the number of diseases developed and spread. Chapter 1 provides data on how climate change has destroyed habitats and displaced millions of animals, forcing them to live under cramped conditions that have …

Soup Minus Shark: How The Shark Finning Industry Continues To Cause Transboundary Environmental Harm, Anna Haase

Student Theses 2015-Present

This thesis paper traverses the practice of shark finning, one of the most lucrative fishing practices and dually the largest threat to shark species’ populations. The process of systematic injury to sharks and the trade of their fins takes place all over the world, and while clearly detrimental to the wellbeing of each individual shark, it is even harsher on environments in which these keystone species are vital to the survival of the ecosystem around it. Chapter 1 of this paper explores several reports and studies encapsulating the most prevalent problems and negative externalities within the shark-finning industry, both in …

The Impact Of A Post-Prescription Review And Feedback Antimicrobial Stewardship Program In Lebanon, Anita B. Shallal, Chloe Lahoud, Dunia Merhej, Sandra Youssef, Jelena Verkler, Linda M. Kaljee, Tyler Prentiss, Seema Joshi, Marcus J. Zervos, Madonna Matar

Infectious Diseases Articles

Antimicrobial stewardship programs (ASPs) are effective means to optimize prescribing practices. They are under-utilized in the Middle East where many challenges exist for ASP implementation. We assessed the effectiveness of infectious disease physician-driven post-prescription review and feedback as an ASP in Lebanon. This prospective cohort study was conducted over an 18-month period in the medical, surgical, and intensive care units of a tertiary care hospital. It consisted of three phases: the baseline, intervention, and follow-up. There was a washout period of two months between each phase. Patients aged ≥16 years receiving 48 h of antibiotics were included. During the intervention …

Health Equity & Obesity Management: An Improvement Project In A Federally Qualified Healthcare Center In Central Harlem, Brianna Bouchez

Doctor of Nursing Practice Scholarly Projects

Description of the problem: Obesity is a growing healthcare problem worldwide with extraordinary costs to the individual's health and the healthcare system. Individuals most affected by obesity include socioeconomically disadvantaged individuals, often with limited resources to seek specialized care.

Available knowledge: Various weight-loss interventions exist but access and success rates vary. Weight loss is often modest and additional factors such as social determinants of health, health literacy, and patient motivation are all factors important to the success of an intervention.

Specific Aims: The purpose of this quality improvement project was to improve self-regulatory weight loss behaviors and increase weight loss …

Transmission Risk Of Covid-19 In High School And College Water Polo, Raymond J Kreienkamp, Christopher J Kreienkamp, Cindy Terrill, Mark E Halstead, Jason G Newland

2020-Current year OA Pubs

BACKGROUND: Concerns that athletes may be at a higher risk for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission has led to reduced participation in sports during the COVID-19 pandemic. We aimed to assess COVID-19 incidence and transmission during the spring 2021 high school and college water polo seasons across the United States.

METHODS: This prospective observational study enrolled 1825 water polo athletes from 54 high schools and 36 colleges. Surveys were sent to coaches throughout the season, and survey data were collected and analyzed.

RESULTS: We identified 17 COVID-19 cases among 1223 high school water polo athletes (1.4%) and …

Country Reports On Practical Aspects Of Conducting Large-Scale Community Studies Of The Tolerability Of Mass Drug Administration With Ivermectin/Diethylcarbamazine/Albendazole For Lymphatic Filariasis, Purushothaman Jambulingam, Swaminathan Subramanian, Kaliannagounder Krishnamoorthy, Taniawati Supali, Peter Fischer, Christine Dubray, Carl Fayette, Jean Frantz Lemoine, Moses Laman, Christopher King, Josaia Samuela, Myra Hardy, Gary J Weil

2020-Current year OA Pubs

This article is a compilation of summaries prepared by lead investigators for large-scale safety and efficacy studies on mass drug administration of IDA (ivermectin, diethylcarbamazine, and albendazole) for lymphatic filariasis. The summaries highlight the experiences of study teams that assessed the safety and efficacy of IDA in five countries: India, Indonesia, Haiti, Papua New Guinea, and Fiji. They also highlight significant challenges encountered during these community studies and responses to those challenges that contributed to success.

Lessons From Large-Scale Tolerability And Acceptability Studies Of Triple Drug Mass Drug Administration Performed To Support Policy Change And Accelerate Elimination Of Lymphatic Filariasis, Gary J Weil, Peter U Fischer, Alison Krentel

2020-Current year OA Pubs

Early clinical trials clearly demonstrated the superior efficacy of triple drug therapy with ivermectin plus DEC and albendazole (IDA) for clearing microfilaremia (Mf) in individuals with lymphatic filariasis (LF). Although these initial pharmacokinetic and efficacy studies were necessary first steps in the clinical development of IDA, they were not sufficient to justify policy changes necessary for widespread use of this new regimen by national filariasis elimination programs. Processes and procedures that led to the World Health Organization's (WHO) endorsement of IDA as a mass drug administration (MDA) regimen for LF are reviewed elsewhere in this Supplement. However, the "guideline review …

Large-Herbivore Nemabiomes: Patterns Of Parasite Diversity And Sharing, Georgia C. Titcomb, Johan Pansu, Matthew C. Hutchinson, Kaia J. Tombak, Christina B. Hansen, Christopher C. M. Baker, Tyler R. Kartzinel, Robert M. Pringle

Publications and Research

Amidst global shifts in the distribution and abundance of wildlife and livestock, we have only a rudimentary understanding of ungulate parasite communities and parasite-sharing patterns. We used qPCR and DNA metabarcoding of fecal samples to characterize gastrointestinal nematode (Strongylida) community composition and sharing among 17 sympatric species of wild and domestic large mammalian herbivore in central Kenya. We tested a suite of hypothesis-driven predictions about the role of host traits and phylogenetic relatedness in describing parasite infections. Host species identity explained 27 – 53% of individual variation in parasite prevalence, richness, community composition and phylogenetic diversity. Host and parasite phylogenies …

Hepatitis B And D: A Forecast On Actions Needed To Reduce Incidence And Achieve Elimination, Scott Greenhalgh, Andrew Klug

Spora: A Journal of Biomathematics

Viral hepatitis negatively affects the health of millions, with the worst health outcomes associated with the hepatitis D virus (HDV). Fortunately, HDV is rare and requires prior infection with the hepatitis B virus (HBV) before it can establish infection and transmit. Here, we develop a mathematical model of HBV and HDV transmission in Sub-Saharan Africa to investigate the effects of hepatitis B vaccination on both HBV and HDV. Our findings illustrate a hepatitis B vaccination rate above 0.006 year^-1 reduces hepatitis D by over 90%, and a vaccination rate above 0.0221 year^-1 reduces hepatitis B by over 90%, …

Covid-19 Newsletter (Vol. 118), Center For Disaster Medicine, New York Medical College

COVID-19 Newsletter

No abstract provided.

How Implementing A Digital Competency Management System Reduced Nurse Training Cost And Improved Npd Practitioner Satisfaction In A Pediatric Hospital, Dionne Margallo

Doctoral Projects

Healthcare organizations must have high-quality nursing staff to deliver optimal patient care. Educators and managers evaluate nurses by their performance through nursing competencies, or “knowledge, skills, [and] abilities” (KSA) (American Nurses Association, 2015, p. 86). Traditional competency evaluations and manual tracking posed a problem within one pediatric hospital. Leaders did not have a transparent way to see the knowledge and skills of their nursing staff. This resulted in increased organizational costs due to retraining and increased workload and job dissatisfaction among educators. The purpose of this quality improvement (QI) project was to evaluate how implementing a digital competency management system …

Novel Mobility Index Tracks Covid-19 Transmission Following Stay-At-Home Orders, Peter Hyunwuk Her, Sahar Saeed, Khai Hoan Tram, Sahir R Bhatnagar

Open Access Publications

Considering the emergence of SARS-CoV-2 variants and low vaccine access and uptake, minimizing human interactions remains an effective strategy to mitigate the spread of SARS-CoV-2. Using a functional principal component analysis, we created a multidimensional mobility index (MI) using six metrics compiled by SafeGraph from all counties in Illinois, Ohio, Michigan and Indiana between January 1 to December 8, 2020. Changes in mobility were defined as a time-updated 7-day rolling average. Associations between our MI and COVID-19 cases were estimated using a quasi-Poisson hierarchical generalized additive model adjusted for population density and the COVID-19 Community Vulnerability Index. Individual mobility metrics …