Digital Commons Network^™

Host Gut Resistome In Gulf War Chronic Multisymptom Illness Correlates With Persistent Inflammation, Dipro Bose, Somdatta Chatterjee, Ethan Older, Ratanesh Seth, Patricia Janulewicz, Punnag Saha, Ayan Mondal, Jeffrey M. Carlson, Alan W. Decho, Kimberly Sullivan, Nancy Kilmas, Stephen Lasley, Jie Li, Saurabh Chatterjee

Faculty Publications

Chronic multisymptom illness (CMI) affects a subsection of elderly and war Veterans and is associated with systemic inflammation. Here, using a mouse model of CMI and a group of Gulf War (GW) Veterans’ with CMI we show the presence of an altered host resistome. Results show that antibiotic resistance genes (ARGs) are significantly altered in the CMI group in both mice and GW Veterans when compared to control. Fecal samples from GW Veterans with persistent CMI show a significant increase of resistance to a wide class of antibiotics and exhibited an array of mobile genetic elements (MGEs) distinct from normal …

Synthesis And Antibacterial Testing Of Novel Thiosulfonate Compounds, Lindsay I. Blume

USF Tampa Graduate Theses and Dissertations

Methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Staphylococcus aureus (VRSA) are increasing concerns in the medical community. In addition to the threat of Staphylococcus aureus, the increase in number and severity of infections caused by other antibiotic-resistant bacteria is problematic to human health, particularly among the ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter). The antibiotics like the penicillins and cephalosporins used commonly to treat MRSA, VRSA, and ESKAPE pathogens have continued to decline in the effectiveness. Our laboratory has developed a number of new families of anti-MRSA and anti-VRSA antibacterial compounds. In this thesis, …

Serotonin Type 3 Receptor Subunit Gene Polymorphisms Associated With Psychosomatic Symptoms In Irritable Bowel Syndrome: A Multicenter Retrospective Study, Sabrina Berens, Gregory Sayuk, Et Al

2020-Current year OA Pubs

BACKGROUND: Single-nucleotide polymorphisms (SNPs) of the serotonin type 3 receptor subunit (

AIM: To assess the association of

METHODS: In this retrospective study, 623 participants with IBS were recruited from five specialty centers in Germany, Sweden, the United States, the United Kingdom, and Ireland. Depressive, anxiety, and somatization symptoms and sociodemographic characteristics were collected. Four functional SNPs -

RESULTS: Depressive and anxiety symptoms significantly worsened with increasing numbers of minor

CONCLUSION: We have provided the first evidence that

قواعد رفع الضرر وأثرها زمن وباء كورونا (دراسة تأصيلية، مقاصدية، فقهية) Harm Elevation Rules And Its Impact During The Corona Epidemic (An Original, Intentional, Jurisprudential Study), Rasha Al-Zou'bi, Mohamed Alrshdan

Jordan Journal of Islamic Studies

ملخص

خلص هذا البحث إلى أن لقواعد الشريعة الفقهية الكلية المتضمنة لرفع الضرر أثرا عظيما في استخلاص الأحكام الفقهية زمن المستجدات والنوازل المعاصرة، ومنها فيروس كورونا، حيث كان لها مدخلا عظيما في تسهيل كثير من الأحكام الفقهية على الناس ورفع الضرر عنهم، وهي من أعظم القواعد الفقهية في الشريعة، ولم تخرج مع ذلك عن نطاق الحق وموافقة الشرع؛ إذ الشرع أصلا جاء لجلب مصالح العباد، ودفع المفاسد عنهم، وظهر ذلك جليا، في رفع الضرر عنهم في أمور عباداتهم ومعاملاتهم، فمن ذلك رفع الضرر عنهم في الحكم بمشروعية تعقيم المساجد بالكحول وكذلك الأبدان والملابس للمصلين، إضافة لمنع المريض مرضا معديا من …

Evaluation Of Periodontal Status And Cytokine Levels In Saliva And Gingival Crevicular Fluid Of Patients With Inflammatory Bowel Diseases, Andre Paes Batista Da Silva

Faculty Scholarship

Background: Periodontal diseases and inflammatory bowel diseases (IBD, ulcerative colitis [UC] and Crohn disease [CD]) have been reported to present with increased salivary and gingival crevicular fluid (GCF) concentrations of cytokines. The aim of this study was to evaluate the salivary and GCF levels of TNF-α, IL-1β, IL-10, and IL-17A and their associations with the periodontal statuses of UC, CD, and non-IBD patients, and to analyze the interrelationships among these cytokines, IBD conditions, and periodontal diseases. Methods: This cross-sectional study was performed with a total of 131 patients (62 women and 69 men, mean age 42.96±13.02 years). Patients were divided …

The Combination Of Nlcr And Enhances The Sepsis-3 Strategy, Emmy Hermiyanti Pranggono, Endah Nurul Aini, Uun Sumardi, Yovita Hartranti, Adhi Kristianto Sugianli

Folia Medica Indonesiana

Highlights: • The combination of NLCR and PLR will improve the ability to distinguish infection rather than noninfection in the emergency setting for early antibiotic prescribing as well as the sepsis-3 strategy. • The diagnostic value of PLR in adult bacterial sepsis patients has never been studied. Abstract: According to Sepsis-3, antibiotics should be administered in the first hour of diagnosis of sepsis. Still, there is difficulty in differentiating between bacterial and nonbacterial infections and a lack of a rapid diagnostic tool to distinguish them. This study evaluated the diagnostic value of NLCR and PLR in suspected bacterial sepsis. The …

Patient Satisfaction, Perception-Expectation Gap, And Costumer Satisfaction Index In Annual Survey 2021 At Dr. Soetomo General Academic Hospital, Cita Rosita Sigit Prakoeswa, Nur Hidayah, Arlina Dewi, Indah Purnamasari, Agus Aan Adriansyah, Amak M. Yaqub

Folia Medica Indonesiana

Highlights: • Customers expectations at Dr. Soetomo General Academic Hospital has a higher quality of service. • The handling of complaints has a low performance on the quality of services at Dr. Soetomo General Academic Hospital. • Improving service quality requires improvements in efficient complaint handling. Abstract: Service quality is essential in health institutions that can affect patient satisfaction and loyalty. The growth in the number of patients at Dr. Soetomo General Academic Hospital, Surabaya, Indonesia, triggered the diversification of services that require periodic quality control. This study aimed to investigate the performance of 31 departments/units in the hospital, the …

Managing Human Resources For Surge Capacity In Referral Hospitals Based On Who Hospital Readiness Checklist For Covid-19, Fitri Dinia, Laksono Trisnantoro, Mochamat Helmi

Folia Medica Indonesiana

Highlights: • Managing human resources for surge capacity in three referral hospital at West Kalimantan was evaluated. • Availability, mobilization and recruitment, duties division, and hospital staff welfare are the reasons for referral hospitals in West Kalimantan are not optimal to face surge capacity during the Covid-19 pandemic. • Provincial Health Office role had not been optimal in the HR management at referral hospitals during the Covid-19 pandemic. Abstract: One of the components of effective disaster response management to deal with surge capacity in referral hospitals in West Kalimantan, Indonesia, was to ensure the adequacy of the number of human …

The Post-Pandemic Order: A Blueprint For Balancing Health And Ip Interests In The Age Of Covid Variants, Arjun Padmanabhan, Tanner J. Wadsworth

Penn State Journal of Law & International Affairs (2012 - Present)

In December 2021, the World Health Assembly (“WHA”) convened to develop a pandemic response treaty for future pandemics. Unfortunately, as presently envisioned, the resulting pandemic response framework will suffer from many of the same inadequacies that prevented existing frameworks from responding effectively to COVID-19. The threat of new pandemics emerging in the future—and new variants developing in the present—call for a more integrated, robust, comprehensive solution.

This Article lays a blueprint for that solution: a global multilateral Council empowered to (1) investigate developing pandemics; (2) incentivize pharmaceutical companies to rapidly-produce vaccines and share them through voluntary licenses or TRIPS compulsory …

Infection-Free Landscape: Adaptable Urban Open Space Design During And After The Covid-19 Pandemic, Weirong Luo

Masters Theses

The ongoing COVID-19 pandemic has profoundly impacted the public perception, usage, and behaviors of urban open spaces. During the past three years, spatial measures to reduce the transmission of infection such as quarantine and social distancing have resulted in people’s isolation and reduction of daily physical interaction with others. Urban open spaces, including streets, squares, and parks, are outdoor urban spaces open for public access and recreation. From Frederick Law Olmsted’s design of New York’s Central Park to Daniel Burnham’s 1909 Plan of Chicago, the United States has a long history of planning and designing the urban environment for better …

The Cost Of Living In Larger Primate Groups Includes Higher Fly Densities, Jan F. Gogarten, Mueena Jahan, Sébastien Calvignac-Spencer, Colin A. Chapman, Tony L. Goldberg, Fabian H. Leendertz, Jessica M. Rothman

Publications and Research

Flies are implicated in carrying and mechanically transmitting many primate pathogens. We investigated how fly associations vary across six monkey species (Cercopithecus ascanius, Cercopithecus mitis, Colobus guereza, Lophocebus albigena, Papio anubis, and Piliocolobus tephrosceles) and whether monkey group size impacts fly densities. Fly densities were generally higher inside groups than outside them, and considering data from these primate species together revealed that larger groups harbored more flies. Within species, this pattern was strongest for colobine monkeys, and we speculate this might be due to their smaller home ranges, suggesting that movement patterns may influence fly–primate associations. Fly associations increase with …

A Preliminary Study Of Proinflammatory Cytokines And Depression Following West Nile Virus Infection, Allison Lino, Timothy A. Erickson, Melissa Nolan Ph.D., Mph, Kristy O. Murray, Shannon E. Ronca

Faculty Publications

West Nile virus (WNV) is a neurotropic flavivirus that can cause acute febrile illness leading to neuroinvasive disease. Depression is a well-described outcome following infection, but the underlying pathogenic mechanisms are unknown. Proinflammatory cytokines play important roles in WNV infection, but their role in depression post-WNV remains unstudied. This research aimed to retrospectively evaluate associations between proinflammatory cytokines and new onset depression in a WNV cohort. Participants with asymptomatic WNV infection were significantly less likely to report new onset depression when compared to those with symptomatic disease. Participants with encephalitis and obesity were significantly more likely to report new onset …

Staph Infection: Hospitals Battle Against A Deadly Menace, Mckenzie Lamos

Undergraduate Research Symposium

Staph infection is caused by the staphylococcus bacteria, which is found on the skin or within the nose of even healthy individuals. This bacteria is usually harmless, but deadly infectious diseases may arise when it enters deep within the body. Staph infection is commonly treated with antibiotics, however the methicillin-resistant Staphylococcus aureus (MRSA) strain is resistant to antibiotics which further complicates treatment. This research provides insight on preventative measures to stop and slow the spread of staph infection in hospitals, along with what is being done to limit the number of MRSA infections. The CDC and NCBI both outline strategies …

Resolving The Repression Pathway Of Virulence Gene Hila In Salmonella, Alexandra King, Lon Chubiz Phd, Brenda Pratte, Lauren Daugherty

Undergraduate Research Symposium

Salmonella is a relatively abundant, virulent species of bacteria that is most known for spreading gastrointestinal diseases through food. These illnesses result in approximately 1.35 million infections, including over 25,000 hospitalizations each year, in the U.S. alone (CDC.gov). As antibiotic resistance becomes an increasingly urgent public health problem, the importance of developing alternative treatment methods is only becoming more crucial. One of the genes responsible for this virulence is known as hilA. HilA is the main transcriptional regulator of Salmonella Pathogenicity Island-1 gene (UniProt). SPI-1 plays an important role in the invasion of Salmonella into epithelial cells. The proteins encoded …

Monkey Pox: Ignored Or Emerging Pathogen, Karoll J. Cortez

CHED Talks

No abstract provided.

Radiation Isolation And The Impact Of Care: Nursing Knowledge And Perception Of Radiation Risks, Bae P. Chu

Dissertations and Theses

Background: The safety challenges encountered when employing ionizing radiation to treat patients and manage radiation exposure and contamination have been well established in previous research. However, little is known about nurses’ understanding of the risks associated with ionizing radiation and how they respond to their own perceptions of risk. Although a wealth of literature shows an association between radiation treatment and negative patient experiences, there remains a lack of understanding of the basis of these perceptions among nurses. Increased ionizing radiation diagnoses and treatment means that nurses are at a higher risk of radiation exposure today than thirty years ago. …

Efficacy And Harms Of Tocilizumab For The Treatment Of Covid-19 Patients: A Systematic Review And Meta-Analysis, Alejandro Piscoya, Angela Parra Del Riego, Renato Cerna-Viacava, Jonathon Rocco, Yuani M. Roman, Angel A. Escobedo, Vinay Pasupuleti, C. Michael White, Adrian V. Hernandez

Internal Medicine Articles

INTRODUCTION: We systematically assessed benefits and harms of tocilizumab (TCZ), which is an antibody blocking IL-6 receptors, in hospitalized COVID-19 patients.

METHODS: Five electronic databases and two preprint webpages were searched until March 4, 2021. Randomized controlled trials (RCTs) and inverse probability treatment weighting (IPTW) cohorts assessing TCZ effects in hospitalized, COVID-19 adult patients were included. Primary outcomes were all-cause mortality, clinical worsening, clinical improvement, need for mechanical ventilation, and adverse events (AE). Inverse variance random-effects meta-analyses were performed with quality of evidence (QoE) evaluated using GRADE methodology.

RESULTS: Nine RCTs (n = 7,021) and nine IPTW cohorts (n = …

Governmental Persuasion Strategies On Social Media During Covid-19: A Comparative Study Of The Us And China, Fan Wang

Hatfield Graduate Journal of Public Affairs

This study compared persuasive strategies of the governments of the U.S. and China during a public health crisis using social media messages. Collecting data with R and Python from two national public health sectors' official accounts on Twitter (N = 1,630) and Sina Weibo (N = 3,554), the researcher investigated how the organizations' messages reflected Cialdini's seven principles of persuasion and whether other emergent messaging patterns occurred. According to the different phases that the two countries had gone through during the pandemic, the researcher also conducted a pooled times series analysis to investigate the relationship between the frequency of daily …

Antimicrobial Mechanisms Of Biomaterials: From Macro To Nano, Shounak Roy, Sanchita Sarkhel, Deepali Bisht, Samerender Nagam Hanumantharao, Smitha Rao, Amit Jaiswal

Michigan Tech Publications, Part 1

Overcoming the global concern of antibiotic resistance is one of the biggest challenge faced by scientists today and the key to tackle this issue of emerging infectious diseases is the development of next-generation antimicrobials. The rapid emergence of multi-drug resistant microbes, superbugs and mutated strains of viruses have fueled the search for new and alternate antimicrobial agents with broad-spectrum biocidal activity. Biomaterials, ranging from macroscopic polymers, proteins, and peptides to nanoscale materials such as nanoparticles, nanotubes and nanosheets have emerged as effective antimicrobials. An extensive body of research has established the antibacterial and antiviral efficiencies of different types of biomaterials. …

Self-Replicating Technologies: Do They Exhaust Patent Rights?, Li Guo

Journal of Technology Law & Policy

This Article proceeds as follows. Part I provides relevant background on the law of patent exhaustion. Part II details the restricted sale at the Supreme Court and the conditional sale at the Federal Circuit. Part III discusses various self-replicating technologies and explains that not all self-replicating technologies are the same. Some are capable of easily reproducing an unlimited number of copies, while others may require a significant amount of resource and human intervention to replicate. Additionally, under certain circumstances, an article can be induced to make a similar, but not identical copy. An example of this is a DNA segment …

Science And Curation Considerations For The Design Of A Mars Sample Return (Msr) Sample Receiving Facility (Srf), Brandi L. Carrier, David W. Beaty, Aurore Hutzler, Alvin L. Smith, Gerhard Kminek, Michael A. Meyer, Timothy Haltigin, Lindsey E. Hays, Carl B. Agee, Henner Busemann, Barabara Cavalazzi, Charles S. Cocksell, Vinciane Debaille, Daniel P. Glavin, Monica M. Grady, Ernst Hauber, Bernard Marty, Francis M., Lisa M. Pratt, Aaron B. Regberg, Caroline L. Smith, Roger E. Summons, Timothy D. Swindle, Kimberly T. Taiit, Nocholas J. Tosca, Arya Urdry, Tomohiro Usui, Michael A. Velbel, Meenakshi Wadhwa, Frances Westall, Maria-Paz Zorzano

Geoscience Faculty Research

The most important single element of the “ground system” portion of a Mars Sample Return (MSR) Campaign is a facility referred to as the Sample Receiving Facility (SRF), which would need to be designed and equipped to receive the returned spacecraft, extract and open the sealed sample container, extract the samples from the sample tubes, and implement a set of evaluations and analyses of the samples. One of the main findings of the first MSR Sample Planning Group (MSPG, 2019a) states that “The scientific community, for reasons of scientific quality, cost, and timeliness, strongly prefers that as many sample-related investigations …

2022-June-02-Mba Capstone Project Collaborates With Ciidi Clinical Research Office, University Marketing And Communication, East Tennessee State University

ETSU News

JOHNSON CITY (June 2, 2022) – The Center of Excellence in Inflammation, Infectious Disease and Immunity (CIIDI) at East Tennessee State University expanded operations in 2021 by creating a Clinical Research Office on the Quillen College of Medicine campus. The office functions as a facilitator for interprofessional and cross-disciplinary investigators as it pertains to basic, preclinical, clinical, and epidemiologic research.

“With CIIDI’s influx of recruitment rates, sample acquisition, and additional large-scale collaborative efforts, it was imperative to create a formal Clinical Research Office,” said James Adkins, director. “We have secured a physical space where the biomedical community can access our …

Raising Is A High-Performance Method For Identifying Random Transgene Integration Sites, Yusaku Wada, Ariella L G Coler-Reilly, Et Al

Open Access Publications

Both natural viral infections and therapeutic interventions using viral vectors pose significant risks of malignant transformation. Monitoring for clonal expansion of infected cells is important for detecting cancer. Here we developed a novel method of tracking clonality via the detection of transgene integration sites. RAISING (Rapid Amplification of Integration Sites without Interference by Genomic DNA contamination) is a sensitive, inexpensive alternative to established methods. Its compatibility with Sanger sequencing combined with our CLOVA (Clonality Value) software is critical for those without access to expensive high throughput sequencing. We analyzed samples from 688 individuals infected with the retrovirus HTLV-1, which causes …

The Pandemic And Privacy: The Global Culture Of Intrusion, Jon L. Mills, Lucca Viana, Danielle Black

Legislation and Policy Brief

No abstract provided.

Four New Species Of Dictyostelids From Soil Systems In Northern Thailand, James C. Cavender, Eduardo M. Vadell, Allison L. Perrigo, John C. Landolt, Steven L. Stephenson, Pu Liu

Environmental & Plant Biology Open Access Publications

Dictyostelid cellular slime molds (dictyostelids) are ubiquitous microorganisms found in the uppermost layers of most soils. Reports on the species diversity of dictyostelids in Southeast Asia, particularly Thailand, are few in number. A survey for dictyostelids performed in northern Thailand in 2008 recovered 15 distinctive forms, including several common species and a number of forms morphologically different from anything already described. Five of the latter were formally described as new to science in a previous paper. An additional five isolates appeared to be morphologically distinct, and this was supported by DNA sequence data and phylogenetic analysis. These isolates representing four …

(R1507) Mathematical Modeling And Analysis Of Seqiahr Model: Impact Of Quarantine And Isolation On Covid-19, Manoj Kumar Singh, . Anjali

Applications and Applied Mathematics: An International Journal (AAM)

At the moment in time, an outbreak of COVID-19 is transmitting on from human to human. Different parts have different quality of life (e.g., India compared to Russia), which implies the impact varies in each part of the world. Although clinical vaccines are available to cure, the question is how to minimize the spread without considering the vaccine. In this paper, via a mathematical model, the transmission dynamics of novel coronavirus with quarantine and isolation facilities have been proposed. The examination of the proposed model is set in motion with the boundedness and positivity of the solution, sole disease-free equilibrium, …

Asean-Korea Strategic Partnership In New Asian Regionalism, Rachel Liting Chang

Centre for Commercial Law in Asia

Over the past two decades, Asia has witnessed increasing regional trade integration with the rapid increase of free trade agreements (FTAs), constituting almost half of global trade pacts. Such a phenomenon has been said to give rise to “new Asian regionalism”, which is defined as a fundamental change in the multilateral trading system. It is a novel and normative integration process which focuses on ASEAN, and in particular the ASEAN Plus Six framework underlying Asia’s increasing economic power.

Managing Solid Waste Contaminated With A Category A Infectious Substance, Providence - Special Pathogens Program

Category A Waste Resources

No abstract provided.

Efficacy Of Antimicrobial Interventions Used In Meat Processing Plants Against Antimicrobial Tolerant Non–Antibiotic-Resistant And Antibiotic-Resistant Salmonella On Fresh Beef, Norasak Kalchayanand, Sapna Chitlapilly Dass, Yangjunna Zhang, Eric L. Oliver, Bing Wang, Tommy L. Wheeler

Roman L. Hruska U.S. Meat Animal Research Center: Reports

Salmonella is a common cause of foodborne illness in the United States, and several strains of Salmonella have been identified as resistant to antibiotics. It is not known whether strains that are antibiotic resistant (ABR) and that have some tolerance to antimicrobial compounds are also able to resist the inactivation effects of antimicrobial interventions used in fresh meat processing. Sixty-eight Salmonella isolates (non-ABR and ABR strains) were treated with half concentrations of lactic acid (LA), peracetic acid (PAA), and cetylpyridinium chloride (CPC), which are used in beef processing plants to screen for tolerant strains. Six strains each from non-ABR and …

Torn Between Two Pandemics: Poverty Pandemic And Coronavirus Pandemic In Nigeria, Tope Shola Akinyetun

Southern African Journal of Policy and Development

The wave of coronavirus pandemic that hit the world coincides with Nigeria’s struggles with her newly attained position as the poverty capital of the world. This paper argues that prevalent poverty is a pandemic that the world has learnt to live with, and that Nigeria is struggling to overcome. The agony of poverty in the country coupled with the coronavirus pandemic subjects the country to a quandary of a dual-pandemic scourge. The paper relies on secondary data and adopts a descriptive and analytic approach. It concludes that multidimensional poverty in Nigeria is pervasive and has become deepened by the pandemic …