Digital Commons Network^™

“Temporal Not Permanent:” The Impact Of Covid-19 Cities Lockdown On Improving Air Quality — A Critical Review Of Africa, Emmanuel Mensah Aboagye, Felix Mensah, Kwaku Obeng Effah, Sandylove Afrane, Jeffrey Dankwa Ampah, Selina Annah Brenyah

Journal of Environmental Sustainability

The WHO declared the novel Covid-19 virus a global pandemic shortly after it broke out. The deadly virus spread has affected human health and seriously halted many economic and industrial activities globally. However, there has been a blight as there has generally been an improvement in air quality since the deadly Covid-19 pandemic caused various governments to lockdown their cities to regulate the spread of the virus. Since the widespread of Covid-19, there have been several researches to measure the extent of impact Covid-19 city lockdown has had global air quality, but no critical review has been done in Africa …

Left Ventricular Assist Device (Lvad) Driveline Infection Rates Between Two Different Dressing Methods, Gretchen Compton

Dissertations

Problem: Heart failure has a growing impact on Americans, and this contributes to an increased number of patients requiring treatment for advanced heart failure. Typical treatment options may include cardiac transplant or the implantation of a left ventricular assist device (LVAD). The use of an LVAD requires sterile management of an external driveline site. Driveline infections are a common complication in this patient population and can lead to chronic complications. There are no published guidelines on the management of the driveline site. This project aimed to provide evidence that can be used in the establishment of standardized guidelines for driveline …

Effect Of Various Preterm Infant Milk Formulas On Nec-Like Gut Injury In Mice., Karishma Rao, Alain Cuna, Susana Chavez-Bueno, Heather Menden, Wei Yu, Ishfaq Ahmed, Pugazhendhi Srinivasan, Shahid Umar, Venkatesh Sampath

Manuscripts, Articles, Book Chapters and Other Papers

Formula feeding is an important risk factor for the development of necrotizing enterocolitis in preterm infants. The potential harmful effects of different preterm formulas on the developing intestinal tract remain incompletely understood. Here we demonstrate that feeding newborn mouse pups with various preterm formulas resulted in differing effects on intestinal inflammation, apoptosis, and activation of the pro-inflammatory transcription factor NFκB. 16S rRNA sequencing revealed that each preterm formula resulted in significant gut microbial alterations that were different from dam-fed controls. Formula feeding with EleCare and Similac Special Care caused greater intestinal injury compared to NeoSure. Pre-treatment with Lactobacillus rhamnosus GG …

Drug-Target Network Study Reveals The Core Target-Protein Interactions Of Various Covid-19 Treatments, Yulin Dai, Hui Yu, Qiheng Yan, Bingrui Li, Andi Liu, Wendao Liu, Xiaoqian Jiang, Yejin Kim, Yan Guo, Zhongming Zhao

Faculty, Staff and Student Publications

The coronavirus disease 2019 (COVID-19) pandemic has caused a dramatic loss of human life and devastated the worldwide economy. Numerous efforts have been made to mitigate COVID-19 symptoms and reduce the death rate. We conducted literature mining of more than 250 thousand published works and curated the 174 most widely used COVID-19 medications. Overlaid with the human protein-protein interaction (PPI) network, we used Steiner tree analysis to extract a core subnetwork that grew from the pharmacological targets of ten credible drugs ascertained by the CTD database. The resultant core subnetwork consisted of 34 interconnected genes, which were associated with 36 …

A Changing Epidemic And The Rise Of Opioid-Stimulant Co-Use, Saeed Ahmed, Zouina Sarfraz, Azza Sarfraz

Department of Paediatrics and Child Health

No abstract provided.

Programmable Rna-Guided Large Dna Transgenesis By Crispr/Cas9 And Site-Specific Integrase Bxb1., Vishnu Hosur, Benjamin E. Low, Michael V. Wiles

Faculty Research 2022

The inability to insert large DNA constructs into the genome efficiently and precisely is a key challenge in genomic engineering. Random transgenesis, which is widely used, lacks precision, and comes with a slew of drawbacks. Lentiviral and adeno-associated viral methods are plagued by, respectively, DNA toxicity and a payload capacity of less than 5 kb. Homology-directed repair (HDR) techniques based on CRISPR-Cas9 can be effective, but only in the 1-5 kb range. In addition, long homology arms-DNA sequences that permit construct insertion-of lengths ranging from 0.5 to 5 kb are required by currently known HDR-based techniques. A potential new method …

Cd169 (Siglec-1) As A Robust Human Cell Biomarker Of Toll-Like Receptor 9 Agonist Immunotherapy, Stine Sofie Frank Lende, Marie H. Pahus, Ida Monrad, Rikka Olesen, Anna Mahr, Line K. Vibholm, Lars Østergaard, Ole Schmeltz Søgaard, Anna Halling Folkmar Andersen, Paul Denton, Martin Tolstrup

Biology Faculty Publications

Immunotherapy is a promising therapeutic area in cancer and chronic viral infections. An important component of immunotherapy in these contexts is the activation of innate immunity. Here we investigate the potential for CD169 (Siglec 1) expression on monocytes to serve as a robust biomarker for activation of innate immunity and, particular, as a proxy for IFN-α production. Specifically, we investigated the effects of Toll-like receptor 9 agonism with MGN1703 (lefitolimod) across experimental conditions ex vivo, in humanized mice, and in clinical trial participants. Ex vivo we observed that the percentage of classical monocytes expressing CD169 increased dramatically from …

Covid-19 Newsletter (Vol. 126), Center For Disaster Medicine, New York Medical College

COVID-19 Newsletter

No abstract provided.

The Experiences Of Older Formerly Incarcerated Adults In A Specialized Reentry Program During The Covid-19 Pandemic, Robin O'Hanlon, Jessica Broome

Publications and Research

A growing area of concern among prison reform advocates and human rights activists is the “greying prison population” or the continuous, unified growth in the number of older incarcerated individuals. Older individuals experience an accelerated aging process while incarcerated, but are less likely to reoffend upon release. While the aging prison population has in recent years become a focus of criminological and gerontological scholars, the lived experience of older formerly incarcerated individuals during the reentry process remains understudied. Using a qualitative approach, this cohort study seeks to further elucidate the unique needs, beliefs, and perceptions of this population within the …

South African University Staff And Students’ Perspectives, Preferences, And Drivers Of Hesitancy Regarding Covid-19 Vaccines: A Multi-Methods Study, Gavin George, Michael Strauss, Emma Lansdell, Nisha Nadesan-Reddy, Numfundo Moroe, Tarylee Reddy, Ingrid Eshun-Wilsonova, Mosa Moshabela

2020-Current year OA Pubs

No abstract provided.

Etiology Of Persistent Microalbuminuria In Nigeria (P_Micro Study): Protocol And Study Design, C William Wester, Philip J Budge, Et Al.

2020-Current year OA Pubs

BACKGROUND: Microalbuminuria is an independent risk factor for cardiovascular and kidney disease and a predictor of end organ damage, both in the general population and in persons with HIV (PWH). Microalbuminuria is also an important risk factor for mortality in PWH treated with antiretroviral therapy (ART). In the ongoing Renal Risk Reduction (R3) study in Nigeria, we identified a high prevalence of microalbuminuria confirmed by two measurements 4-8 weeks apart in ART-experienced, virologically suppressed PWH. Although Stage 1 or 2 hypertension and exposure to potentially nephrotoxic antiretroviral medications were common in R3 participants, other traditional risk factors for albuminuria and …

Assessing Smoking Status And Risk Of Sars-Cov-2 Infection: A Machine Learning Approach Among Veterans, Alice B S Nono Djotsa, Drew A Helmer, Catherine Park, Kristine E Lynch, Amir Sharafkhaneh, Aanand D Naik, Javad Razjouyan, Christopher I Amos

Center for Medical Ethics and Health Policy Staff Publications

The role of smoking in the risk of SARS-CoV-2 infection is unclear. We used a retrospective cohort design to study data from veterans' Electronic Medical Record to assess the impact of smoking on the risk of SARS-CoV-2 infection. Veterans tested for the SARS-CoV-2 virus from 02/01/2020 to 02/28/2021 were classified as: Never Smokers (NS), Former Smokers (FS), and Current Smokers (CS). We report the adjusted odds ratios (aOR) for potential confounders obtained from a cascade machine learning algorithm. We found a 19.6% positivity rate among 1,176,306 veterans tested for SARS-CoV-2 infection. The positivity proportion among NS (22.0%) was higher compared …

Using Medical Education As A Tool To Train Doctors As Social Innovators, Nagina Khan, Anne Rogers, Colin Melville, Rohit Shankar, Wolfgang Gilliar, Peter Byrne, Alex Serafimov, Sridevi Sira Mahalingappa, Simran Sehdev, Anna Sri, Subodh Dave

Peninsula Medical School

Introduction Current medical education prepares doctors to diagnose, assess and treat individual patients yet lacks the expectation to be responsible for the care of the wider community. Learning the skills to recognise and redress the social determinants of health are increasingly being recognised as an essential part of medical education. Objectives The goal of this research was (1) to investigate how medical education can be leveraged to reduce health inequalities through the role and practice of doctors and (2) to elucidate how key innovations in medical education are a necessity that can support doctors as € change agents.' Methods Two …

2022-07-02_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus/stats/coronavirus-symptoms. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated twice a week on Mondays and Thursdays.

Syndromic Surveillance System data is obtained from approximately 216 facilities participating in syndromic surveillance (139 Emergency Departments (ED), 77 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, …

The Development Potential For Local Communities Of Religious Tourists Visiting Sacred Graves, Mohammad Taufiq Rahman, Rully Khairul Anwar

International Journal of Religious Tourism and Pilgrimage

This study aims to analyse the impact of religious tourists’ visits to tombs of saints. It illustrates the effect of these visits on the economic development of the surrounding community. This is qualitative research with a sociological approach used to determine the public acceptance of religious tourism to sacred places such as the Tomb of the Islamic Saints in Tasikmalaya, West Java, Indonesia. The results show that the community has made economic use of tourists that perform pilgrimages to fulfil their psychological needs, such as peace, tranquillity, and a sense of security. Furthermore, local governments’ development of religious tourism makes …

The Economic Impact Of Covid-19 On Religious Tourism To The Kartarpur Corridor, Farooq Haq, Anita Medhekar

International Journal of Religious Tourism and Pilgrimage

The aim of this paper is to analyse the economic impact of the COVID-19 pandemic on religious tourism in the Kartarpur Gurdwara Corridor between the Punjab States of Pakistan and India. The corridor was opened as a peace building initiative 72 years after the partition of India-Pakistan. In November 2019, thousands of Sikh pilgrims visited Kartarpur and Nankana Sahib in Punjab to celebrate the 550th birth anniversary of the founder of the Sikh religion Guru Nanakji, where he spent last 19 years of his life. The Government of Pakistan invested heavily to build the infrastructure facilities for connecting both borders …

Pattern And Magnitude Of Utilization Of Information Resource Facilities And Services At Health Sciences Library In The Midst Of Covid – 19 Pandemic, Saima Aamir, Nosheen Mahmood, Zahida Anjum, Noura Bin Hewaishel, Ikram Ul Haq

Library Philosophy and Practice (e-journal)

Background: Medical librarians support curriculum and research by delivering appropriate and high-quality information and facilities to students and faculty members. COVID-19 pandemic disrupted physical teaching and learning worldwide endorsing virtual education which was supported by digital information resources. The purpose of this study was to evaluate the extent of utilization of physical and digital learning resources along with customer satisfaction in a health science library before and during the COVID-19 pandemic.

Methods: An online self-administered questionnaire was administered using Microsoft Forms to students and faculty members. Data were analyzed using SPSS version 24. Qualitative variables were analyzed using mean and …

The Institute Of Archaeology & Siegfried H. Horn Museum Newsletter Volume 43.3, Paul Gregor, Robert Bates, Constance Gane, Trisha Broy, Paul J. Ray Jr.

Institute of Archaeology & the Horn Archaeological Museum Newsletter

Khirbat Safra 2022, Paul Gregor, Robert Bates, Constance Gane, Trisha Broy, and Paul J. Ray, Jr.

Random Survey

The Greenbook, Faculty Handbook, 2022-2023, Marshall University Academic Affairs

The Greenbook

This book has been published for the faculty of Marshall University for the specified period of time. This book was created by what is now known as Academic Affairs and is for the period of 2022-2023.

Synergistic Antibacterial Activity With Conventional Antibiotics And Mechanism Of Action Of Shikonin Against Methicillin‐Resistant Staphylococcus Aureus, Qian Qian Li, Hee Sung Chae, Ok Hwa Kang, Dong Yeul Kwon

Faculty and Student Publications

Methicillin‐resistant Staphylococcus aureus (MRSA) is a troublesome pathogen that poses a global threat to public health. Shikonin (SKN) isolated from Lithospermum erythrorhizon (L. erythro-rhizon) possesses a variety of biological activities. This study aims to explore the effect of the combined application of SKN and traditional antibiotics on the vitality of MRSA and the inherent anti-bacterial mechanism of SKN. The synergies between SKN and antibiotics against MRSA and its clinical strain have been demonstrated by the checkerboard assay and the time‐kill assay. The effect of SKN on disrupting the integrity and permeability of bacterial cell membranes was verified by a nucleotide …

Perceptions And Readiness Of Foodservice Establishments At The Onset Of The Covid-19 Pandemic In Metro Manila And Region Iv-A, Philippines, Von Ryan M. Ebron, Irma U. Danao, Marie Faye R. Nguyen- Orca, Anna Teresa O. Orillo, Joyce P. Parco

Journal of Economics, Management and Agricultural Development

The study evaluated the perceptions and readiness of food business operators about COVID-19 through an online survey with respondents from Metro Manila and Region IV-A. Generally, they are knowledgeable about COVID-19 and its transmission, as reflected in their scores. The same is true about their attitude towards “new normal” practices. Years of operation, asset size, and continued operations and delivery services showed significant positive correlation with attitude scores. The resilience of some food business operators may be attributed to having more resources that enabled them to carry the added costs of what the new normal foodservice practices entailed. New normal …

An Investigation Of Anti-Intellectualism Among Nurses, Jamie Davis-Tubbs

Dissertations

Anti-intellectualism is often offered as an explanation for irrational actions, especially in the grips of uncertainty. The effects of the COVID-19 pandemic have uncovered the consequences of anti-intellectualism within the healthcare system. Nurses, the most identifiability trusted healthcare professionals, have been used to illustrate a healthcare paradox regarding COVID-19. The healthcare paradox presents nurses as highly trained healthcare professionals who do not believe in their own science and reject scientific expertise. Furthermore, nursing anti-intellectualism has been used to spread misinformation during a major health crisis. Yet, we do not know the depth in which anti-intellectualism exists within the nursing profession. …

Evaluation Of Silver Nanoparticles Attached To Methylene Blue As An Antimicrobial Agent And Its Cytotoxicity, Somon Hakimov

Masters Theses & Specialist Projects

Antibiotics resistance is considered as one of the greatest public health challenges of our time. In this work, we have synthesized silver nanoparticles (Ag NPs) using pulsed liquid ablation in different medium of growth and later combined with methylene blue (MB) to evaluate its potential as an effective photodynamic therapy agent. Ag NPs were synthesized by pulsed laser ablation technique in Polyvinylpyrrolidone (PVP), citrate, and Polyvinyl alcohol (PVA). The Ag NPs were characterized using transmission electron microscopy (TEM), UV-Visible (UV-Vis), and photoluminescence (PL) spectra. Next, Ag NPs were coupled with MB and used to deactivate the Gram-negative bacteria, Escherichia coli …

Total Prevention: A History Of Schistosomiasis In Japan, Alexander Bay

History Faculty Articles and Research

In Japan, schistosomiasis was endemic in Yamanashi Prefecture and a few other hotspot areas where the Miya’iri snail lived. The parasite’s lifecycle relied on the intermediary Miya’iri snail as well as the human host. Parasite eggs passed into the agrarian environment through untreated night soil used as fertiliser or through the culture of open defecation in rural Japan. Manmade rice fields and irrigation ditches, night soil covered paddies and highly refined growing seasons put people in flooded rice paddies to intensively work the land in the spring and summer. The disease was equally dependent on human intervention in the natural …

Effects Of Education On Correcting Misconceptions And Acceptance Of The Influenza Vaccination Among A College Campus, Travis E. Fairbanks

Doctor of Nursing Practice Scholarly Projects

Educating patients on the influenza vaccination is an important goal for health care providers. It fosters a working relationship between provider and patient and allows patients to make an informed decision on their health care needs. The percentage of individuals who receive the influenza vaccine in the United States has been consistently below goals set by the committee for Healthy People 2020. This DNP scholarly project aimed to determine whether the introduction of education was effective at increasing individuals’ choice to vaccinate against the influenza virus among college campus students. The study was a non-experimental, non-randomized control trial that utilized …

Implementation Of An Advanced Operating Room Schedule To Increase Compliance With Clinical Practice Guidelines For Preoperative Antibiotic Selection And Timing: A Quality Improvement Project, Shelby Lynne Adams

Doctor of Nursing Practice Scholarly Projects

Surgical site infection (SSI) is a major cause of morbidity and mortality in operative patients worldwide. The American Society for Health-System Pharmacists (ASHP) published the most recent clinical practice guidelines for antimicrobial prophylaxis in surgery. These guidelines are based upon the available evidence and provide a standardized approach for the safe and effective selection, dosing, and administration of antibiotics for the prevention of SSI (Bratzler et al., 2013). This Doctor of Nursing Practice (DNP) project aimed to determine if incorporating an advanced operating room (OR) schedule, inclusive of ASHP presurgical antibiotics, increased compliance with ASHP standards of antibiotic selection and …

Special Issue: Biofilm Composition And Applications, Bindu Subhadra

Faculty Publications - Biological Sciences

Generally, EPS may be hydrophobic, although it can be both hydrophilic and hydrophobic [9]. Since EPS is highly hydrated, it helps to prevent desiccation in some natural biofilms [9]. Currently, there is increasing interest in the use of biofilm-forming microorganisms as bioremediation agents, as they convert hazardous environmental substances (pollutants such as oil spills; organic pollutants such as polycyclic aromatic hydrocarbons and polychlorinated biphenyls; and polychlorinated ethenes, heavy metals, dyes, explosives, pesticides, and pharmaceutical products) into less toxic or harmless compounds [20,29]. [...]excess nutrients (nitrogen and phosphorus) in the wastewater also need to be removed to avoid anoxia [32]. [...]the …

Antibody Responses To Sars-Cov-2 After Infection Or Vaccination In Children And Young Adults With Inflammatory Bowel Disease., Joelynn Dailey, Lina Kozhaya, Mikail Dogan, Dena Hopkins, Blaine Lapin, Katherine Herbst, Michael Brimacombe, Kristen Grandonico, Fatih Karabacak, John Schreiber, Bruce Tsan-Liang Liang, Juan C Salazar, Derya Unutmaz, Jeffrey S Hyams

Faculty Research 2022

BACKGROUND: Characterization of neutralization antibodies to SARS-CoV-2 infection or vaccination in children and young adults with inflammatory bowel disease (IBD) receiving biologic therapies is crucial.

METHODS: We performed a prospective longitudinal cohort study evaluating SARS-CoV-2 spike protein receptor binding domain (S-RBD) IgG positivity along with consistent clinical symptoms in patients with IBD receiving infliximab or vedolizumab. Serum was also obtained following immunization with approved vaccines. The IgG antibody to the spike protein binding domain of SARS-CoV-2 was assayed with a fluorescent bead-based immunoassay that takes advantage of the high dynamic range of fluorescent molecules using flow cytometry. A sensitive and …

Characteristics Of Community-Acquired Carbapenem-Resistant Enterobacterales, Rima Shrestha, Courtney L. Luterbach, Weixiao Dai, Lauren Komarow, Michelle Earley, Gregory Weston, Erica Herc, Jesse T. Jacob, Robert Salata, Darren Wong, Deverick Anderson, Kirsten B. Rydell, Cesar A. Arias, Liang Chen, David Van Duin

Infectious Diseases Articles

No abstract provided.

A Review Of Covid-19 In Relation To Metabolic Syndrome: Obesity, Hypertension, Diabetes, And Dyslipidemia, Elias Makhoul, Joseph L. Aklinski, Jesse Miller, Cara Leonard, Sean Backer, Payal Kahar, Mayur S. Parmar, Deepesh Khanna

HPD Articles

Although severe cases and mortality of coronavirus disease 2019 (COVID-19) are proportionally infrequent, these cases are strongly linked to patients with conditions of metabolic syndrome (obesity, hypertension, diabetes, and dyslipidemia). However, the pathophysiology of COVID-19 in relation to metabolic syndrome is not well understood. Thus, the goal of this secondary literature review was to examine the relationship between severe acute respiratory syndrome (SARS-CoV-2) infection and the individual conditions of metabolic syndrome. The objective of this secondary literature review was achieved by examining primary studies, case studies, and other secondary studies, to obtain a comprehensive perspective of theories and observations of …