Digital Commons Network^™

Progressive Acceleration Of Insulin Exposure Over 7 Days Of Infusion Set Wear, Jasmin R. Kastner, Timothy S. Bailey, Poul Strange, Leon Shi, Keith A. Oberg, Paul J. Strasma, Jeffrey I. Joseph, Douglas B. Muchmore

Department of Anesthesiology Faculty Papers

Insulin exposure varies over 3 days of insulin infusion set (IIS) wear making day-to-day insulin dosing challenging for people with diabetes (PWD). Here we report insulin pharmacodynamic (PD) and pharmacokinetic (PK) data extending these observations to 7 days of IIS wear. PWD (A1C ≤8.5%, C-peptide tmax (P < 0.001), Cmax (P < 0.05), and mean residence time (P < 0.0001). Area under the insulin concentration curve (AUC0–300) declined by ∼24% from days 0 to 7 (P < 0.05). These results confirm/extend previous observations showing progressive acceleration of insulin exposure over IIS wear time. This may have implications for PWD and designers of closed-loop algorithms, although larger studies are necessary to confirm this. The study was registered in clinicaltrials.gov (NCT04398030).

Correlations Between Complex Human Phenotypes Vary By Genetic Background, Gender, And Environment, Michael Elgart, Matthew O Goodman, Carmen Isasi, Han Chen, Alanna C Morrison, Paul S De Vries, Huichun Xu, Ani W Manichaikul, Xiuqing Guo, Nora Franceschini, Bruce M Psaty, Stephen S Rich, Jerome I Rotter, Donald M Lloyd-Jones, Myriam Fornage, Adolfo Correa, Nancy L Heard-Costa, Ramachandran S Vasan, Ryan Hernandez, Robert C Kaplan, Susan Redline, Tamar Sofer

Faculty, Staff and Student Publications

We develop a closed-form Haseman-Elston estimator for genetic and environmental correlation coefficients between complex phenotypes, which we term HEc, that is as precise as GCTA yet ∼20× faster. We estimate genetic and environmental correlations between over 7,000 phenotype pairs in subgroups from the Trans-Omics in Precision Medicine (TOPMed) program. We demonstrate substantial differences in both heritabilities and genetic correlations for multiple phenotypes and phenotype pairs between individuals of self-reported Black, Hispanic/Latino, and White backgrounds. We similarly observe differences in many of the genetic and environmental correlations between genders. To estimate the contribution of genetics to the observed phenotypic correlation, we …

Digital Technology Enables Construction Of National Governance Modernization, Yue Hao, Kaihua Chen, Jin Kang, Xiaoguang Yang, Chao Zhang, Xiaolong Zheng

Bulletin of Chinese Academy of Sciences (Chinese Version)

As digital technologies continue to be integrated into the whole process of economic and social development, promoting the modernization of digital technology-enabled national governance systems and capabilities has become an important way to seize the strategic initiative in the future world competitive landscape, and has attracted the attention of countries around the world. The rapid development of digital technologies such as big data collection, storage, processing, and analysis is constantly optimizing the organizational system structure of national governance, upgrading and perfecting the quality and methods of national governance personnel, and accelerating the process of making national governance efficient, scientific, intelligent …

Challenges And Measurements For Governance Of Modern Cyber Space Society, Pinghui Wang, Hongbin Pei, Junzhou Zhao, Tao Qin, Chao Shen, Dongliang Liu, Xiaohong Guan

Bulletin of Chinese Academy of Sciences (Chinese Version)

The rapid development of information technology has unprecedentedly created a prosperous cyber society and greatly enhanced productivity facilitated by social interaction. At the same time, many problems emerge in the cyber society, such as telecom fraud, privacy leakage, Internet pollution, and algorithmic discrimination. The problems bring new challenges to social order and security. In order to find the way of cyber society governance and promote the modernization of national governance, this paper first presents the analyses on the new problems encountered in the cyber society in three typical scenarios, i.e., identity governance, behavior governance, and algorithm governance, as well as …

Deepening Digital Technologies To Enable Modernization Of China’S Governance Of Health, Tara Qia Sun, Xia Feng, Yuntao Long, Zongben Xu

Bulletin of Chinese Academy of Sciences (Chinese Version)

One significant goal of science and technology innovation is to set our sights on the health and safety of the people. The rapid development of digital technologies provides multiple potentials and path to achieve the modernization of China's health governance. the role of digital technologies on enabling multiple stakeholders (i.e., hospitals, doctors, government, and social groups) to improve the supply capacity, the inclusiveness, fairness, friendliness, and convenience of health service. Second, we explore the four key issues of using digital technologies to enable the governance of health construction of digital health infrastructures, the factors affecting the adoption of digital technologies, …

Strategic Perspective Of Leveraging New Generation Information Technology To Enable Modernization Of Emergency Management, Haibo Zhang, Xinyu Dai, Depei Qian, Jian Lyu

Bulletin of Chinese Academy of Sciences (Chinese Version)

The application and development of the new generation information technology is a vital support to realize the modernization of emergency management. At present, the new generation information technology such as big data and artificial intelligence has been widely used in natural disasters, safe production, and other fields. It has improved the monitoring and early warning, regulation and law enforcement, command and decision support, rescue, and social mobilization capabilities of governments, promoted the level of intrinsic safety of enterprises, provided important support for the precise prevention and control of the COVID-19, and increased the efficiency of China’s emergency management and sense …

Layout And Suggestions On China’S Science And Technology Innovation Centers At Different Levels, Wenzhong Zhang

Bulletin of Chinese Academy of Sciences (Chinese Version)

Science and technology innovation center plays an important role in transforming the mode of economic development and enhancing industrial competitiveness. The formation and development of science and technology innovation center depend on the gathering of innovative talents, the support of first-rate universities and research institutions, and the cooperation and mutual promotion between innovation organizations and enterprises. In the course of future development, China should build a multi-level network system of science and technology innovation centers with international centers which can connect to global innovation networks, national centers which are capable of leading national science and technology research and development and …

Ecological Green Integration In Yangtze River Delta From Perspective Of Intercity Green Technology Transfer, Debin Du, Hong Jin, Dezhong Duan

Bulletin of Chinese Academy of Sciences (Chinese Version)

Green technology innovation is the core driving force for the high-quality development of regional integration in the Yangtze River Delta, and the free flow of innovative elements represented by green technology across cities is the due meaning of the construction of ecological green integration in the Yangtze River Delta. Based on the inter-city green patent transfer data from 2001 to 2020, this study analyzed the characteristics of the spatial evolution of green technology diffusion in the Yangtze River Delta, and discussed the development degree of ecological green integration in the area from the three levels of overall development, green technology …

2022 Issue 12 Content

Bulletin of Chinese Academy of Sciences (Chinese Version)

No abstract provided.

Rhetoric And Affect In Undergraduate Research: A Diary Study, Kristine Johnson, J. Michael Rifenburg

University Faculty Publications and Creative Works

In this article, we examine undergraduate research as a site of rhetorical development by listening to undergraduate researchers narrate and reflect upon their work as it unfolds. We draw from diary entries and follow-up interviews with eighteen undergraduate researchers at two different institutions, analyzing the rhetorical and affective elements of undergraduate research. Connecting undergraduate research with the concept of meaningful writing, we conclude by offering recommendations for teachers, mentors, and administrators.

Xcvatr: Detection And Characterization Of Variant Impact On The Embeddings Of Single -Cell And Bulk Rna-Sequencing Samples, Arif Harmanci, Akdes Serin Harmanci, Tiemo J Klisch, Akash J Patel

Duncan NRI Faculty and Staff Publications

Background: RNA-sequencing has become a standard tool for analyzing gene activity in bulk samples and at the single-cell level. By increasing sample sizes and cell counts, this technique can uncover substantial information about cellular transcriptional states. Beyond quantification of gene expression, RNA-seq can be used for detecting variants, including single nucleotide polymorphisms, small insertions/deletions, and larger variants, such as copy number variants. Notably, joint analysis of variants with cellular transcriptional states may provide insights into the impact of mutations, especially for complex and heterogeneous samples. However, this analysis is often challenging due to a prohibitively high number of variants and …

Labial Frenotomy For Symptomatic Isolated Upper Lip Tie, Cecilia G Freeman, Jason F Ohlstein, Nicholas A Rossi, John B Mcintire, Luis D Neve, Shiva Daram, Harold S Pine

Faculty, Staff and Student Publications

BACKGROUND: The benefits and challenges of successful breastfeeding for both mother and child have been well-established in the literature. While ankyloglossia, or tongue tie, alone or in combination with upper lip tie has been the focus of several previous studies, very few have directly addressed isolated symptomatic upper lip tie and the role of surgical correction for breastfeeding difficulties.

MATERIALS AND METHODS: Seven infants with isolated upper lip tie and breastfeeding difficulty were taken to the operating room for labial frenotomy. These infants were assessed at their follow-up visits for their degree of weight gain since their procedure. Their mothers …

Spatial Heterogeneity Of Infiltrating T Cells In High-Grade Serous Ovarian Cancer Revealed By Multi-Omics Analysis, Bin Yang, Xiong Li, Wei Zhang, Junpeng Fan, Yong Zhou, Wenting Li, Jingjing Yin, Xiaohang Yang, Ensong Guo, Xi Li, Yu Fu, Si Liu, Dianxing Hu, Xu Qin, Yingyu Dou, Rourou Xiao, Funian Lu, Zizhuo Wang, Tianyu Qin, Wei Wang, Qinghua Zhang, Shuaicheng Li, Ding Ma, Gordon B Mills, Gang Chen, Chaoyang Sun

Faculty, Staff and Student Publications

Tumor-infiltrating lymphocytes (TILs), especially CD8+ TILs, represent a favorable prognostic factor in high-grade serous ovarian cancer (HGSOC) and other tumor lineages. Here, we analyze the spatial heterogeneity of different TIL subtypes in HGSOC. We integrated RNA sequencing, whole-genome sequencing, bulk T cell receptor (TCR) sequencing, as well as single-cell RNA/TCR sequencing to investigate the characteristics and differential composition of TILs across different HGSOC sites. Two immune "cold" patterns in ovarian cancer are identified: (1) ovarian lesions with low infiltration of mainly dysfunctional T cells and immunosuppressive Treg cells and (2) omental lesions infiltrated with non-tumor-specific bystander cells. Exhausted CD8 T …

Structural Insights Into Cardiolipin Replacement By Phosphatidylglycerol In A Cardiolipin-Lacking Yeast Respiratory Supercomplex, Elena G Govorunova, Oleg A Sineshchekov, Leonid S Brown, Ana-Nicoleta Bondar, John L Spudich

Faculty, Staff and Student Publications

Potassium-selective channelrhodopsins (KCRs) are light-gated K+ channels recently found in the stramenopile protist Hyphochytrium catenoides. When expressed in neurons, KCRs enable high-precision optical inhibition of spiking (optogenetic silencing). KCRs are capable of discriminating K+ from Na+ without the conventional K+ selectivity filter found in classical K+ channels. The genome of H. catenoides also encodes a third paralog that is more permeable for Na+ than for K+. To identify structural motifs responsible for the unusual K+ selectivity of KCRs, we systematically analyzed a series of chimeras and mutants of this protein. We found that mutations of three critical residues in the …

Emergency Remote Teaching Versus Planned Remote Teaching: Narrowing The Gap With Targeted Professional Development, Bonnie J. Covelli, Sudipta Roy

Higher Learning Research Communications

Objectives: This study reviews faculty members’ comfort level with remote teaching in the Fall 2020 semester to evaluate the effectiveness of the professional development workshops.

Method: Using survey research, we examined professional development activities and subsequent comfort level and ease of adjustment with remote teaching in Fall 2020.

Results: Following the training, faculty reported high planned usage of various online teaching tools and great comfort with using them. The data reveals some differences between part-time and full-time faculty members.

Conclusions: The experience gained in the emergency semester, combined with the targeted professional development workshops offered eased the stress of planned …

In-Depth Analysis Of Alternative Splicing Landscape In Multiple Myeloma And Potential Role Of Dysregulated Splicing Factors, Anil Aktas Samur, Mariateresa Fulciniti, Herve Avet-Loiseau, Michael A Lopez, Sanika Derebail, Jill Corre, Stephane Minvielle, Florence Magrangeas, Philippe Moreau, Kenneth C Anderson, Giovanni Parmigiani, Mehmet K Samur, Nikhil C Munshi

Faculty, Staff and Student Publications

Splicing changes are common in cancer and are associated with dysregulated splicing factors. Here, we analyzed RNA-seq data from 323 newly diagnosed multiple myeloma (MM) patients and described the alternative splicing (AS) landscape. We observed a large number of splicing pattern changes in MM cells compared to normal plasma cells (NPC). The most common events were alterations of mutually exclusive exons and exon skipping. Most of these events were observed in the absence of overall changes in gene expression and often impacted the coding potential of the alternatively spliced genes. To understand the molecular mechanisms driving frequent aberrant AS, we …

Chitosan Oligosaccharides As A Nanomaterial Platform: Biological Properties And Applications In The Biomedical And Pharmaceutical Fields, Muhamad Alif Razi

Makara Journal of Science

Chitosan oligosaccharides (COS) have been introduced as marine-derived biomaterials with potential health benefits and good water solubility properties. This study presents an overview of the promising nanomaterial platform for biomedical and pharmaceutical applications of COS. The health benefits of COS, primarily their antioxidant and protective effects, anti-inflammatory activity, antidiabetic properties, and cholesterol-lowering effects are discussed. Furthermore, the promising recent articles on specific topics such as drug delivery systems and nanobiomaterials, are highlighted

Temperature Influence On The Optical Properties, Attenuation Coefficient, And Total Molecular Cross Section Of Dhunge Dhara Drinking Water, Saddam Husain Dhobi, Bibek Koirala, Kishori Yadav, Jeevan Jyoti Nakarmi, Suresh Prasad Gupta, Santosh Kumar Das, Arun Kumar Shah, Kuldip Paudel, Kushal Dahal, Ram Lal Sah

Makara Journal of Science

This work aims to measure the different parameters of Dhunge Dhara water (DDW) such as absorbance, transmittance, mass attenuation coefficient (MAC), and molecular cross section (MCS) and experimentally compare the obtained values with those of pure water (PW) at various temperatures (5 °C to 90 °C) using a theremino spectrometer. Observation shows that the parameters vary with temperature and wavelength. The transmittance of DDW ranges from 18% to 85% and absorbance of the same ranges from 0.09 Au to 0.7 Au. Meanwhile, the transmittance of PW ranges from 40% to 98% and the absorbance of the same ranges from 0.09 …

Determination Of Total Ammonia Nitrogen By Gas-Diffusion Flow Injection Analysis (Gd-Fia)-Spectrophotometry Using Minnieroot Flower (Ruellia Tuberosa) As Natural Reagent, Lani Artana Putri, Puspita Mufidah Sari, Hermin Sulistyarti, Akhmad Sabarudin, Erwin Sulistyo

Makara Journal of Science

Total ammonia nitrogen (TAN) is a pollutant agent found in water and generated from the metabolisms of living organisms and the decomposition of organic matter. This research aims to develop an efficient, low-cost, and environmentally friendly TAN analysis method. The principle of this method is based on the reaction of TAN injected in the donor stream with NaOH to form alkaline gaseous ammonia. The gaseous ammonia diffuses through a hydrophobic membrane into an acceptor stream containing Ruellia tuberosa extract. The presence of NH₃ gas in the acceptor stream changes the extract color from pinkish to green, which is monitored …

Application Of Accuracy And Precision Evaluations Based On The Current United States And Indonesian Pharmacopoeias: A Critical Review, Gunawan Indrayanto

Makara Journal of Science

New methods for the evaluation of accuracy and precision are mentioned in the latest edition of the United States Pharmacopoeia (USP), whereas other validation parameters, that is, selectivity, linearity, range, and robustness, remained relatively unchanged. In obtaining reliable data from any chemical/pharmaceutical analysis, the analytical procedure must be validated or verified in accordance with the latest edition of the pharmacopoeia. Some review articles on the general validation methods have been published by the author. This present review will focus on the implementation and discussion of the accuracy and precision evaluation based on the current USP and Indonesian pharmacopoeia. Some examples …

Community Engagement For Birth Preparedness And Complication Readiness In The Community Level Interventions For Pre-Eclampsia (Clip) Trial In India: A Mixed-Method Evaluation, Avinash Kavi, Mai-Lei Woo Kinshella, Umesh Y Ramadurg, Umesh Charantimath, Geetanjali M Katageri, Chandrashekhar C Karadiguddi, Narayan V Honnungar, Shashidhar G Bannale, Geetanjali I Mungarwadi, Jeffrey N Bone, Marianne Vidler, Laura Magee, Ashalata Mallapur, Shivaprasad S Goudar, Mrutyunjaya Bellad, Richard Derman, Peter Von Dadelszen, The Clip India Working Group

Department of Obstetrics and Gynecology Faculty Papers

Objective: To describe the process of community engagement (CE) in northern Karnataka, India and its impact on pre-eclampsia knowledge, birth preparedness and complication readiness, pregnancy-related care seeking and maternal morbidity.

Design: This study was a secondary analysis of a cluster randomised trial of Community Level Interventions for Pre-eclampsia (CLIP). A total of 12 clusters based on primary health centre catchment areas were randomised to intervention or control. CE was conducted in intervention clusters. CE attendance was summarised according to participant group using both quantitative and qualitative assessment. Pre-eclampsia knowledge, birth preparedness, health services engagement and perinatal outcomes was evaluated within …

Type Iv Pili Are A Critical Virulence Factor In Clinical Isolates Of Paenibacillus Thiaminolyticus, Christine Hehnly, Petra Erdmann Gilmore, R. Reid Townsend, David D. Limbrick, Et Al.

2020-Current year OA Pubs

Hydrocephalus, the leading indication for childhood neurosurgery worldwide, is particularly prevalent in low- and middle-income countries. Hydrocephalus preceded by an infection, or postinfectious hydrocephalus, accounts for up to 60% of hydrocephalus in these areas. Since many children with hydrocephalus suffer poor long-term outcomes despite surgical intervention, prevention of hydrocephalus remains paramount. Our previous studies implicated a novel bacterial pathogen, Paenibacillus thiaminolyticus, as a causal agent of neonatal sepsis and postinfectious hydrocephalus in Uganda. Here, we report the isolation of three

Comparison Of Endoscopic Thyroidectomy By Complete Areola Approach And Conventional Open Surgery In The Treatment Of Differentiated Thyroid Carcinoma: A Retrospective Study And Meta-Analysis, Yuquan Yuan, Chenyu Sun, Tingjie Yin, Cong Shao, Bin Pan, Dengwei Lu, Shaodong Hou, Scott Lowe, Rachel Bentley, Shuya Chen, Christy Huang, Ce Cheng, Yaru Li, Bethany King, Qin Zhou, Cunye Yan, Fan Zhang

Student Publications

Background: The feasibility of endoscopic thyroidectomy by complete areola approach (ETCA) remains controversial. This study was conducted by combining our clinical data with the data obtained from a systematic review literature search to examine the effectiveness and safety of ETCA compared with conventional open thyroidectomy (COT) in differentiated thyroid carcinoma (DTC).

Methods: A total of 136 patients with a diagnosis of DTC who underwent unilateral thyroidectomy with central neck dissection from August 2020 to June 2021 were enrolled. The enrolled patients were divided into the ETCA group (n = 73) and the COT group (n = 63). The …

Surface Modification Of 3d Printed Microfluidic Devices For Controlled Wetting In Two-Phase Flow, Chandler A. Warr, Nicole G. Crawford, Gregory P. Nordin, William G. Pitt

Faculty Publications

Microfluidic devices (MFDs) printed in 3-D geometry using digital light projection to polymerize monomers often have surfaces that are not as hydrophobic as MFDs made from polydimethylsiloxane. Droplet microfluidics in these types of devices are subject to droplet adhesion and aqueous spreading on less hydrophobic MFD surfaces. We have developed a post-processing technique using hydrophobic monomers that renders the surfaces of these devices much more hydrophobic. The technique is fast and easy, and involves flowing monomer without initiator into the channels and then exposing the entire device to UV light that generates radicals from the initiator molecules remaining in the …

Nature Of Β-1,3-Glucan-Exposing Features On Candida Albicans Cell Wall And Their Modulation, Leandro Jose De Assis, Jm Bain, C Liddle, I Leaves, C Hacker, Da Silva R Peres, R Yuecel, A Bebes, D Stead, Ds Childers, A Pradhan, K Mackenzie, K Lagree, De Larcombe, Q Ma, Gm Avelar, Mg Netea, Lp Erwig, Ap Mitchell, Gd Brown, Nar Gow, Ajp Brown

Peninsula Medical School

Microbes that coexist with humans have evolved ways of avoiding or evading our immunological defenses. These include the masking by these microbes of their “pathogen-associated molecular patterns” (PAMPs), which are recognized as “foreign” and used to activate protective immunity.

Arnis-Based Exercise Program For Balance Control In Community-Dwelling Older Adults: Study Protocol For A Pilot Randomized Controlled Trial, Donald Lipardo, Donald Manlapaz, Vergel B. Orpilla, Jim Carlo S. Buan, Jasneer Tricia C. Arevalo, Jaisen Lluch F. Cortez, Kyrell Patrick Desquitado, Vianca Mae L. Geli, Jose Raphael L. Lacorte, Johna R. Masibay, Caitlin Joy A. Sanchez, Alyssa Denise B. Villanueva

Philippine Journal of Physical Therapy

Background: Aging causes impairment in balance and increases the prevalence of falls in older adults. Martial arts are now incorporated into exercise programs to improve balance. Arnis, a Filipino Martial Art, can improve the balance control of older adults.

Objectives: This study primarily aims to determine the effects of an Arnis-based exercise program on balance control of healthy community-dwelling older adults. This study also aims to describe its effect on older adults’ concerns about falling and lower limb functional strength.

Methods:This will be a single-blind, pilot randomized controlled trial. Participants will be randomly allocated to either the intervention or …

Filipino Physical Therapists’ Practice And Perspectives On Non-Treatment Physical Activity For Older Adults, Frances Rom M. Lunar, Attilah Mae B. Alog, Alexa Ds Tanchuling, Kristen Mari Andal, Beatrice Camille Chan, Daniel C. Chua, Claire Beatrice Martinez, Ma. Anna Carmina D. Orlino, Jem Bettina G. Tan, Koji A. Katakura Jr., Marvin Louie S. Ignacio

Philippine Journal of Physical Therapy

Introduction:

Studies have already investigated the practice of physical therapists (PTs) in promoting non-treatment physical activity (NTPA). However, these were done in the context of mostly western settings or were not specific to older adult practice. It is still unclear if a similar level of practice and perspectives on NTPA promotion exists in a setting where physical therapy is more associated with rehabilitation than health promotion, such as in the Philippines. Therefore, this study aimed to describe Filipino PTs' knowledge of WHO physical activity (PA) guidelines and their use of behavioral change techniques (BCTs) and theories when promoting PA in …

Ivf So White, So Medical: Digital Normativity And Algorithm Bias In Infertility On Instagram, Caitlyn M. Jarvis, Margaret M. Quinlan

Human-Machine Communication

Increasingly, women experiencing infertility are turning online to social media platforms, like Instagram, to engage with a support network and foster empathy. However, Instagram is also noted for its augmentation of White, cis, and heteronormative femininity through a process of silencing and minoritizing alternative, non-White voices. Through an inductive analysis of the most frequently used infertility hashtags, we collected and analyzed 252 Instagram posts to investigate how these algorithmic practices may socially construct the idealized IVF experience through communicating normative expectations. We identify predominant patterns of use that reinforce stratification within infertility treatments as primarily accessible to White women and …

Designing A Loving Robot: A Social Construction Analysis Of A Sex Robot Creator’S Vision, Annette Masterson

Human-Machine Communication

In 2018, one of the world’s first sex robots was released by CEO Matt McMullen and his company, RealDoll. With artificial intelligence capabilities, the Harmony model is meant to support and converse with users. Using a social construction of technology theory lens, this study develops the theory’s fourth level of analysis, emphasizing mass media’s construction abilities. A critical discourse analysis of 38 publicity interviews found a tendency to emphasize the companionship of sex robots while envisioning a future where integration is normalized, and a sentient robot is possible. As the creator, McMullen’s vision could determine the future of robotic design, …

The Evolution Of Gendered Software: Products, Scientific Reasoning, Criticism, And Tools, Victoria A. E. Kratel

Human-Machine Communication

Over the past 7 decades, gendered software has become globally established. In this theoretical distribution, I outline the evolution of gendered software. The journey of gendered software started with the raw idea fueled by Alan Turing’s imitation game in the 1950s. And only shortly thereafter, in the 1960s and 1970s, the first gendered software products like Joseph Weizenbaum’s ELIZA were developed. Thus, academia took its time to not only explore technological aspects, but to further investigate the matter of gender in the 1990s CASA-paradigm (Nass et al., 1994) and Media Equation (Reeves & Nass, 1996). As these theories reasoned the …