Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Medicine and Health Sciences (23775)
- Social and Behavioral Sciences (13351)
- Education (8681)
- Life Sciences (7421)
- Medical Specialties (6957)
-
- Law (6280)
- Arts and Humanities (5098)
- Public Health (4416)
- Physical Sciences and Mathematics (4282)
- Medical Sciences (3929)
- Psychology (3177)
- Business (2865)
- Higher Education (2787)
- Engineering (2624)
- Nursing (2477)
- Sociology (2215)
- Diseases (1985)
- Public Affairs, Public Policy and Public Administration (1741)
- Oncology (1535)
- Medical Education (1475)
- Environmental Sciences (1431)
- Sports Sciences (1337)
- Communication (1247)
- Mental and Social Health (1245)
- Health and Physical Education (1224)
- History (1193)
- Rehabilitation and Therapy (1178)
- Bioinformatics (1165)
- Biomedical Informatics (1114)
- Biology (995)
- Institution
-
- The Texas Medical Center Library (3382)
- Washington University School of Medicine (1713)
- Walden University (1362)
- University of Nebraska - Lincoln (1330)
- Chulalongkorn University (1187)
-
- University of Colorado Law School (986)
- Thomas Jefferson University (932)
- Western Michigan University (912)
- University of Montana (903)
- University of Florida Levin College of Law (839)
- University of Mississippi (824)
- Liberty University (800)
- Utah State University (794)
- University of New Hampshire (791)
- University of South Carolina (782)
- University of Plymouth (776)
- University of Kentucky (771)
- University of Alabama at Birmingham (762)
- Georgia Southern University (753)
- City University of New York (CUNY) (751)
- University of Central Florida (713)
- Edith Cowan University (711)
- Universitas Indonesia (708)
- San Jose State University (694)
- University of Memphis (692)
- Aga Khan University (649)
- University of Arkansas, Fayetteville (630)
- Western Kentucky University (629)
- Louisiana State University (620)
- Nova Southeastern University (620)
- Keyword
-
- Humans (3416)
- COVID-19 (2827)
- Animals (944)
- Female (890)
- Mice (667)
-
- Education (638)
- Mental health (628)
- Male (607)
- ICTS (Institute of Clinical and Translational Sciences) (530)
- Michigan (506)
- Adult (485)
- Pandemic (483)
- Child (433)
- Depression (417)
- United States (400)
- SARS-CoV-2 (399)
- Anxiety (326)
- Retrospective Studies (325)
- Children (320)
- Health (320)
- Obesity (316)
- Gender (306)
- Leadership (301)
- Physical activity (298)
- Release (297)
- Stress (294)
- Higher education (290)
- Adolescent (289)
- Covid-19 (289)
- Students (285)
- Publication
-
- Faculty, Staff and Student Publications (2045)
- Theses and Dissertations (1575)
- 2020-Current year OA Pubs (1435)
- Walden Dissertations and Doctoral Studies (1275)
- Session Laws 2001-Present (914)
-
- Faculty Publications (873)
- Dissertations (851)
- Chulalongkorn University Theses and Dissertations (Chula ETD) (836)
- Faculty, Staff and Students Publications (784)
- Electronic Theses and Dissertations (726)
- University of Montana Course Syllabi, 2021-2025 (590)
- Research outputs 2022 to 2026 (579)
- Baltic Journal of Health and Physical Activity (573)
- Florida Law Review (567)
- Doctoral Dissertations and Projects (526)
- Faculty Scholarship (482)
- Honors Theses (461)
- International Journal of Exercise Science: Conference Proceedings (417)
- Articles (393)
- Browse All News (380)
- Silver Bow Creek/Butte Area Superfund Site (333)
- Library Philosophy and Practice (e-journal) (330)
- Theses (306)
- Florida Historical Quarterly (300)
- USF Tampa Graduate Theses and Dissertations (278)
- Open Access Publications (270)
- Turkish Journal of Medical Sciences (244)
- Patient Education Projects (243)
- Publications and Research (243)
- Master's Theses (232)
- Publication Type
Articles 74971 - 75000 of 76355
Full-Text Articles in Entire DC Network
Tales From A Placeholder: A Relational Journey With Land, Place, People And Self, Kalle O. Fox
Tales From A Placeholder: A Relational Journey With Land, Place, People And Self, Kalle O. Fox
Graduate Student Theses, Dissertations, & Professional Papers
The proposed thesis is a collection of place-based, long- and-short-form creative nonfiction essays. The places of interest are where the author spent different amounts of time in during her twenties, including Iceland, Miami and Seaside, Florida, Butte and Missoula, Montana, and a series of National Parks on the western side of the Continental Divide. This thesis is informed what cultural geographer Yi Fu Tuan coined as topophilia: the affective bond between people and place. “Place” and “sense of place,” while each having their own array of definitions in environmental scholarship, are considered interchangeable in the context of my work. A …
The Legacy Of Hurricanes, Historic Land Cover, And Municipal Ordinances On Urban Tree Canopy In Florida (United States), Allyson B. Salisbury, Andrew K. Koeser, Richard J. Hauer, Deborah R. Hilbert, Amr H. Abd-Elrahman, Michael G. Andreu, Katie Britt, Shawn Landry, Mary G. Lusk, Jason W. Miesbauer, Hunter Thorn
The Legacy Of Hurricanes, Historic Land Cover, And Municipal Ordinances On Urban Tree Canopy In Florida (United States), Allyson B. Salisbury, Andrew K. Koeser, Richard J. Hauer, Deborah R. Hilbert, Amr H. Abd-Elrahman, Michael G. Andreu, Katie Britt, Shawn Landry, Mary G. Lusk, Jason W. Miesbauer, Hunter Thorn
School of Geosciences Faculty and Staff Publications
Urban Tree Canopy (UTC) greatly enhances the livability of cities by reducing urban heat buildup, mitigating stormwater runoff, and filtering airborne particulates, among other ecological services. These benefits, combined with the relative ease of measuring tree cover from aerial imagery, have led many cities to adopt management strategies based on UTC goals. In this study, we conducted canopy analyses for 300 cities in Florida to assess the impacts of development practices, urban forest ordinances, and hurricanes on tree cover. Within the cities sampled, UTC ranged from 5.9 to 68.7% with a median canopy coverage of 32.3% Our results indicate that …
Modeling Through, Ryan Calo
Modeling Through, Ryan Calo
Articles
Theorists of justice have long imagined a decision-maker capable of acting wisely in every circumstance. Policymakers seldom live up to this ideal. They face well-understood limits, including an inability to anticipate the societal impacts of state intervention along a range of dimensions and values. Policymakers cannot see around corners or address societal problems at their roots. When it comes to regulation and policy-setting, policymakers are often forced, in the memorable words of political economist Charles Lindblom, to “muddle through” as best they can.
Powerful new affordances, from supercomputing to artificial intelligence, have arisen in the decades since Lindblom’s 1959 article …
Complicated Mercy: Compensating The Wrongfully Convicted In Georgia, Elizabeth O'Roark
Complicated Mercy: Compensating The Wrongfully Convicted In Georgia, Elizabeth O'Roark
Georgia Law Review
An exoneree’s story does not end when they walk out of prison and back into society. After spending years in prison for a crime they did not commit, the exoneree must rebuild a life with years of lost income, little credit, and no retirement. Georgia is one of the few states that does not have a statute setting out how to fairly and efficiently compensate its exonerees. Exonerees must instead ask state representatives to present a resolution to the General Assembly. If the resolution passes through both chambers of the legislature, then the exoneree can receive some compensation for the …
Elementary String Orchestra: A Hybrid Curriculum, Deborah Jeannette Hickey
Elementary String Orchestra: A Hybrid Curriculum, Deborah Jeannette Hickey
Masters Theses
Remote and distance musical instruction can be traced back to the earliest transmissions of radio and television. In the last few decades, it has made considerable strides due to the development of the internet and growing supportive software and online platforms. However, when the COVID-19 virus swept the world, many school districts were forced to convert to full- remote instruction instantaneously. While some unique and beneficial strategies developed out of this, many aspects and strategies proved to be less than ideal and inferior to in-person instruction, particularly where it pertained to performance and ensemble-based instrumental instruction. This project strives to …
Food Security Through Disaster Planning In Tanzania: How Agriculture-Based Disaster Preparedness Can Improve Food Security In Tanzania, Savannah A. Emerich
Food Security Through Disaster Planning In Tanzania: How Agriculture-Based Disaster Preparedness Can Improve Food Security In Tanzania, Savannah A. Emerich
Masters Theses
In Tanzania, half the population lives below the poverty line and suffers from food insecurity. Of the population, women and children primarily suffer from malnutrition due to food insecurity. For Tanzania, the problem is so severe that some women do not name their newborns for weeks or months due to their unlikely survival. This problem worsens for those who have a significant reliance on agriculture and live in the nation’s rural areas. These rural communities face more traumatic burdens when floods and droughts destroy crops, fields, and tools and ruin livelihoods. A solution has not been implemented thus far due …
The Advocate (Fall 2022), Lewis & Clark Law School
"The Working World Is A Minefield": Counterstories Of Job Loss, Rachel Collier Murdock, Matt Baker, Stacy Tye-Williams
"The Working World Is A Minefield": Counterstories Of Job Loss, Rachel Collier Murdock, Matt Baker, Stacy Tye-Williams
Faculty Publications
This study examines narratives told by employees who experienced involuntary job loss. Results expand on previous narrative research investigating the American Dream master narrative and job loss as related to the neoliberal claim that those who work hard will be successful. The study investigated the master narrative’s implications for job loss that if someone loses their job, they must be either flawed or a bad worker. Contributions include a new redeemed-resolved identity construction by individuals who narrated job loss as an opportunity to correct some flaw in either their character or work life and to emerge a better, changed worker. …
Health Equity/Health Disparity
Health Equity/Health Disparity
Virginia Journal of Public Health
Addressing the Digital Health Divide in the Rural U.S.: Healthcare Providers' Perspectives on Telemedicine in Public Libraries
Pamela B. DeGuzman, Jennifer L. Garth, & Kamya Sanjay
Causes of Minority Health Disparities
Calvin Jones
Examining the [Social] Determinants of Health among Immigrant and Refugee Families: Lessons Learned from the Field
Abubakarr Jalloh
Racial Disparities in Routine Health Checkup and Adherence to Cervical Cancer Screening Guidelines among women in the United States
Amarachukwu F. Orji, &Takashi Yamashita
Richmond Law Magazine: Winter 2022, University Of Richmond
Richmond Law Magazine: Winter 2022, University Of Richmond
Richmond Law Magazine
Free Britney (and other legal lessons from the headlines)
The Making of a More Perfect Union
Richmond Law: A Story in 7 Objects
Neuropsychological Outcomes In Individuals With Type 1 And Type 2 Diabetes., Nathaniel M Putnam, Evan L Reynolds, Mousumi Banerjee, Kara Mizokami-Stout, Dana K. Albright Phd, Joyce Lee, Rodica Pop-Busui, Eva L Feldman, Brian C Callaghan
Neuropsychological Outcomes In Individuals With Type 1 And Type 2 Diabetes., Nathaniel M Putnam, Evan L Reynolds, Mousumi Banerjee, Kara Mizokami-Stout, Dana K. Albright Phd, Joyce Lee, Rodica Pop-Busui, Eva L Feldman, Brian C Callaghan
Health Services and Informatics Research
OBJECTIVE: To determine the prevalence of neuropsychological outcomes in individuals with type 1 diabetes compared to individuals with type 2 diabetes or without diabetes, and to evaluate the association of diabetes status and microvascular/macrovascular complications with neuropsychological outcomes.
PATIENTS AND METHODS: We used a nationally representative healthcare claims database of privately insured individuals (1/1/2001-12/31/2018) to identify individuals with type 1 diabetes. Propensity score matching was used as a quasi-randomization technique to match type 1 diabetes individuals to type 2 diabetes individuals and controls. Diabetes status, microvascular/macrovascular complications (retinopathy, neuropathy, nephropathy, stroke, myocardial infarction, peripheral vascular disease, amputations), and neuropsychological outcomes …
Evaluation Of Standardized Psychological Screening For Pediatric Inpatients., Dana K. Albright Phd, Allison Gornik, Melissa Andersen, Kimberly Monroe, Kristin A. Kullgren
Evaluation Of Standardized Psychological Screening For Pediatric Inpatients., Dana K. Albright Phd, Allison Gornik, Melissa Andersen, Kimberly Monroe, Kristin A. Kullgren
Health Services and Informatics Research
Objective: This study aimed to examine the efficacy of a psychological screening tool for hospitalized pediatric patients to identify those at high risk for adjustment difficulties and optimize referrals to pediatric behavioral health (BH) providers. Specifically, this study evaluated the PROMIS® Parent Proxy 25 to capture the psychosocial needs of the inpatient pediatric population admitted to the general medicine floor in a free standing children’s hospital. Methods: The PROMIS® Parent Proxy 25 was administered to parents of children ages 5 to 17 (N = 128). Chart review was used to group children into those who did or did not receive …
Perhaps It Was Too Soon: College Students' Reflections On The Timing Of Their Sexual Debut., Susan Sprecher, Lucia F O'Sullivan, Michelle Drouin, Julie Verette-Lindenbaum, Marion C Willetts
Perhaps It Was Too Soon: College Students' Reflections On The Timing Of Their Sexual Debut., Susan Sprecher, Lucia F O'Sullivan, Michelle Drouin, Julie Verette-Lindenbaum, Marion C Willetts
Health Services and Informatics Research
Early sexual debut has been a focus of social scientific research due to its association with adverse circumstances and negative outcomes. However, there has been a recent shift to considering not only chronological age, but also the degree to which the event is viewed to be optimally timed (i.e., the perception that it occurred at the "right time" versus too soon). The purpose of this study was to assess how individual/family background variables and contextual aspects of the experience (including partner and relationship aspects) are associated with both the actual age at sexual debut and the perceived acceptability of the …
An Oral History Project: Shirley Knutson And Rural Ministry Initiative, Carly Bagley
An Oral History Project: Shirley Knutson And Rural Ministry Initiative, Carly Bagley
Capstone Projects
This project examines oral history methods through a series of interviews with Shirley Knutson. These interviews focus on her life and her intentions for Rural Ministry Initiative, a Lutheran residency program for clergy interns. Shirley describes her experiences in rural communities as a child, student, teacher, wife, and mother. This project aims to help historians understand ethical practices and effective principals when conducting oral history projects while also exploring historical themes of domesticity, religion, and family relations from the perspective of a woman living in the Midwest United States during the mid- to late-20th century.
The Impact Of High Flow Oxygen (Optiflow) And The Risk Of Aspiration In The Adult Population Within Critical Care Environments, Elaine Walsh, Amy Bernd, Tara Huggard, Patricia Schlegel
The Impact Of High Flow Oxygen (Optiflow) And The Risk Of Aspiration In The Adult Population Within Critical Care Environments, Elaine Walsh, Amy Bernd, Tara Huggard, Patricia Schlegel
Department of Medicine
No abstract provided.
Leukoencephalopathy Secondary To Heroin Inhalation: A Noteworthy Consideration, Patrick Davis Md, Sidney Okon, Francis Sean Wilson, David Finch, Beth Stepanczuk Md
Leukoencephalopathy Secondary To Heroin Inhalation: A Noteworthy Consideration, Patrick Davis Md, Sidney Okon, Francis Sean Wilson, David Finch, Beth Stepanczuk Md
Department of Medicine
No abstract provided.
How One Non-Profit Health Care Network Took A Comprehensive Driving Program From Concept To The Streets, Ryan Vetter Ms-Otr/L, Shelley Spence, Jeffrey Halbert Ms, Otr/L, Csrs
How One Non-Profit Health Care Network Took A Comprehensive Driving Program From Concept To The Streets, Ryan Vetter Ms-Otr/L, Shelley Spence, Jeffrey Halbert Ms, Otr/L, Csrs
Department of Medicine
No abstract provided.
Tracking The Implementation Of A Mental Health Smartphone Application At A Large Tertiary Care Health Network, Jennifer Yoon, Katherine B. Martin Md
Tracking The Implementation Of A Mental Health Smartphone Application At A Large Tertiary Care Health Network, Jennifer Yoon, Katherine B. Martin Md
USF-LVHN SELECT
No abstract provided.
Preoperative Immunonutrition And Carbohydrate Loading Associated With Improved Bowel Function After Radical Cystectomy, Sephalie Patel, Nathaniel Trona, Brandon Alford, Jose Laborde, Youngchul Kim, Roger Li, Brandon Manley, Scott Gilbert, Wade Sexton, Phillippe Spiess, Michael Poch
Preoperative Immunonutrition And Carbohydrate Loading Associated With Improved Bowel Function After Radical Cystectomy, Sephalie Patel, Nathaniel Trona, Brandon Alford, Jose Laborde, Youngchul Kim, Roger Li, Brandon Manley, Scott Gilbert, Wade Sexton, Phillippe Spiess, Michael Poch
USF-LVHN SELECT
No abstract provided.
Emergency Department Management Of Pediatric Chest Pain At Lehigh Valley Health Network, Chetna Thawani, Andrew Bressler, Susan K. Yaeger Md, Robert A. Palermo Do
Emergency Department Management Of Pediatric Chest Pain At Lehigh Valley Health Network, Chetna Thawani, Andrew Bressler, Susan K. Yaeger Md, Robert A. Palermo Do
USF-LVHN SELECT
No abstract provided.
Comparison And Outcome Analysis Of E.M. Resident Evidence-Based Medicine Questions, Phillip Sgobba Bs, Mbs, Estelle Cervantes Ba, Shreyas Kudrimoti Ba, Jacob Albers, Jeffrey B. Brown, Kashyap Kaul Do, William Spinosi Do, Ajay Varadhan, Joseph B. Zackary Md, Bryan G. Kane Md
Comparison And Outcome Analysis Of E.M. Resident Evidence-Based Medicine Questions, Phillip Sgobba Bs, Mbs, Estelle Cervantes Ba, Shreyas Kudrimoti Ba, Jacob Albers, Jeffrey B. Brown, Kashyap Kaul Do, William Spinosi Do, Ajay Varadhan, Joseph B. Zackary Md, Bryan G. Kane Md
USF-LVHN SELECT
No abstract provided.
Relationship Between Vaccination Status And Biopsychosocial Characteristics In Sheltered Adolescents, Ceyda H. Sablak Bs, Cecilia E. Zemanek Bs, Nina Liu, Brittany Gaudet Bs, Msph, Taylor Jarvill, Allison N. Kayne Bs, Jeffrey Downen, Hope Kincaid Mph, Cph, Amy B. Smith Phd, Robert D. Barraco Md, Mph, Hoonani M. Cuadrado, Marna R. Greenberg Do, Mph, Facep
Relationship Between Vaccination Status And Biopsychosocial Characteristics In Sheltered Adolescents, Ceyda H. Sablak Bs, Cecilia E. Zemanek Bs, Nina Liu, Brittany Gaudet Bs, Msph, Taylor Jarvill, Allison N. Kayne Bs, Jeffrey Downen, Hope Kincaid Mph, Cph, Amy B. Smith Phd, Robert D. Barraco Md, Mph, Hoonani M. Cuadrado, Marna R. Greenberg Do, Mph, Facep
USF-LVHN SELECT
No abstract provided.
Developing An Art Museum Workshop For Usf Select Medical Students, Ashley Kunnath, Amy B. Smith Phd
Developing An Art Museum Workshop For Usf Select Medical Students, Ashley Kunnath, Amy B. Smith Phd
USF-LVHN SELECT
No abstract provided.
Agents Of Exposure In Transgender Patient Cases Managed By A Toxicologist: An Analysis Of The Toxicology Investigator’S Consortium (Toxic) Registry, Olivia A. Hardy, Alexandra Amaducci Do, Judith Sabino Mph, Cdp, Beth Careyva M.D., Matthew D. Cook Do, Kenneth D. Katz Md, M G. Ryan, Ryan Surmaitis Do, Andrew L. Koons Do, Joseph B. Zackary Md, Gillian A. Beauchamp Md, Marna R. Greenberg Do, Mph, Facep
Agents Of Exposure In Transgender Patient Cases Managed By A Toxicologist: An Analysis Of The Toxicology Investigator’S Consortium (Toxic) Registry, Olivia A. Hardy, Alexandra Amaducci Do, Judith Sabino Mph, Cdp, Beth Careyva M.D., Matthew D. Cook Do, Kenneth D. Katz Md, M G. Ryan, Ryan Surmaitis Do, Andrew L. Koons Do, Joseph B. Zackary Md, Gillian A. Beauchamp Md, Marna R. Greenberg Do, Mph, Facep
USF-LVHN SELECT
No abstract provided.
Exploring The Short-Term Impact Of Provider Education On Lung Cancer Screening In Lvhn Primary Care Practices: A Pilot Quality Improvement Project, Kaylan Griffith, Grant M. Greenberg M.D., M.H.S.A., M.A., Melanie B. Johnson Mpa
Exploring The Short-Term Impact Of Provider Education On Lung Cancer Screening In Lvhn Primary Care Practices: A Pilot Quality Improvement Project, Kaylan Griffith, Grant M. Greenberg M.D., M.H.S.A., M.A., Melanie B. Johnson Mpa
USF-LVHN SELECT
No abstract provided.
Accuracy, Resource Utilization, And Sex And Race Differences Of Myocardial Infarction (Mi) Alerts: A Single-Center Experience In The Application Of A Pre-Hospital Personnel Electrocardiogram (Ecg) Education And Transmission Intervention, Rachael Chaska, Jeanne L. Jacoby Md, Bryan D. Nelson Mba, Nr-P, Orlando E. Rivera Rn, Kashyap Kaul Do, Jay Gopal, Christopher Connell Do, Tyler Willing Do, Jessica Jacoby, Ali Yazdanyar Do, Phd, Bruce Feldman Do, Anita Kurt Phd, Rn, Andrew Ferdock, Joanna Schwab, Nicholas S. Imperato, Katelyn Mclain
Accuracy, Resource Utilization, And Sex And Race Differences Of Myocardial Infarction (Mi) Alerts: A Single-Center Experience In The Application Of A Pre-Hospital Personnel Electrocardiogram (Ecg) Education And Transmission Intervention, Rachael Chaska, Jeanne L. Jacoby Md, Bryan D. Nelson Mba, Nr-P, Orlando E. Rivera Rn, Kashyap Kaul Do, Jay Gopal, Christopher Connell Do, Tyler Willing Do, Jessica Jacoby, Ali Yazdanyar Do, Phd, Bruce Feldman Do, Anita Kurt Phd, Rn, Andrew Ferdock, Joanna Schwab, Nicholas S. Imperato, Katelyn Mclain
USF-LVHN SELECT
No abstract provided.
Falls From Homes, It’S Not Just A Window Problem, Julia Vandenheuvel Md, Michele Dunstan, Kyle Shaak Bs, Sarah A. Jones Sapienza Md, Debra Esernio-Jenssen Md
Falls From Homes, It’S Not Just A Window Problem, Julia Vandenheuvel Md, Michele Dunstan, Kyle Shaak Bs, Sarah A. Jones Sapienza Md, Debra Esernio-Jenssen Md
Department of Pediatrics
No abstract provided.
A Content Analysis Of 100 Qualitative Health Research Articles To Examine Researcher-Participant Relationships And Implications For Data Sharing, Jessica Mozersky, Annie Friedrich, James Dubois
A Content Analysis Of 100 Qualitative Health Research Articles To Examine Researcher-Participant Relationships And Implications For Data Sharing, Jessica Mozersky, Annie Friedrich, James Dubois
Open Access Publications
No abstract provided.
Medication For Opioid Use Disorder At Hospital Discharge Is Not Associated With Intravenous Antibiotic Completion In Post-Acute Care Facilities, Edward C Traver, Patrick R Ching, Shivakumar Narayanan
Medication For Opioid Use Disorder At Hospital Discharge Is Not Associated With Intravenous Antibiotic Completion In Post-Acute Care Facilities, Edward C Traver, Patrick R Ching, Shivakumar Narayanan
Open Access Publications
Background: People with opioid use disorder and severe infections may complete their prolonged courses of outpatient parenteral antimicrobial therapy at a post-acute care facility due to adherence and safety concerns. We hypothesized that treatment with medications for opioid use disorder, such as methadone and buprenorphine, would increase antibiotic completion in these facilities.
Methods: We performed a retrospective cohort study of people with opioid use disorder and severe infections who were discharged from the University of Maryland Medical Center to a post-acute care facility to complete intravenous antibiotic therapy. The primary outcome was completion of outpatient parenteral antimicrobial therapy. We compared …
Sglt2 Inhibitors Therapy Protects Glucotoxicity-Induced Β-Cell Failure In A Mouse Model Of Human Katp-Induced Diabetes Through Mitigation Of Oxidative And Er Stress, Zeenat A. Shyr, Zihan Yan, Alessandro Ustione, Erin M. Egan, Maria S. Remedi
Sglt2 Inhibitors Therapy Protects Glucotoxicity-Induced Β-Cell Failure In A Mouse Model Of Human Katp-Induced Diabetes Through Mitigation Of Oxidative And Er Stress, Zeenat A. Shyr, Zihan Yan, Alessandro Ustione, Erin M. Egan, Maria S. Remedi
Open Access Publications
Progressive loss of pancreatic β-cell functional mass and anti-diabetic drug responsivity are classic findings in diabetes, frequently attributed to compensatory insulin hypersecretion and β-cell exhaustion. However, loss of β-cell mass and identity still occurs in mouse models of human KATP-gain-of-function induced Neonatal Diabetes Mellitus (NDM), in the absence of insulin secretion. Here we studied the temporal progression and mechanisms underlying glucotoxicity-induced loss of functional β-cell mass in NDM mice, and the effects of sodium-glucose transporter 2 inhibitors (SGLT2i) therapy. Upon tamoxifen induction of transgene expression, NDM mice rapidly developed severe diabetes followed by an unexpected loss of insulin content, decreased …