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2022

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Association Of Thiol/Disulphide Homeostasis With Bethesda Classification Of Thyroid Nodules And Thyroid Cancer, Muhammet Cüneyt Bi̇lgi̇ner, Abbas Ali̇ Tam, Sevgül Faki, Bağdagül Yüksel Güler, Özcan Erel, İbrahi̇m Kilinç, Di̇dem Özdemi̇r, Oya Topaloğlu, Reyhan Ersoy, Beki̇r Çakir Jan 2022

Association Of Thiol/Disulphide Homeostasis With Bethesda Classification Of Thyroid Nodules And Thyroid Cancer, Muhammet Cüneyt Bi̇lgi̇ner, Abbas Ali̇ Tam, Sevgül Faki, Bağdagül Yüksel Güler, Özcan Erel, İbrahi̇m Kilinç, Di̇dem Özdemi̇r, Oya Topaloğlu, Reyhan Ersoy, Beki̇r Çakir

Turkish Journal of Medical Sciences

Background/aim: Ultrasonography and fine-needle aspiration biopsy are frequently used to diagnose thyroid cancer. However, supportive data might be required in case of diagnostic difficulty. This study investigated whether there is a relationship between thiol/ disulphide homeostasis and cytological and histopathological diagnosis of thyroid nodules. Materials and methods: The patient group consisted of 81 individuals with euthyroid nodular (single/multiple) goiter scheduled for thyroidectomy, and the control group consisted of 28 age- and sex-matched healthy volunteers who had no thyroid nodule on ultrasonographic evaluation. All participants were selected among the admissions to the study clinic between June 2017 and June 2018, and …

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The Correlation Of Serum Spd-1 And Spd-L1 Levels With Clinical, Pathological Characteristics And Lymph Node Metastasis In Nonsmall Cell Lung Cancer Patients, Burcu Ancin, Mesut Meli̇h Özercan, Yi̇ği̇t Yilmaz, Serkan Uysal, Ulaş Kumbasar, Zeynep Saribaş, Erkan Di̇kmen, Riza Doğan, Meti̇n Demi̇rci̇n Jan 2022

The Correlation Of Serum Spd-1 And Spd-L1 Levels With Clinical, Pathological Characteristics And Lymph Node Metastasis In Nonsmall Cell Lung Cancer Patients, Burcu Ancin, Mesut Meli̇h Özercan, Yi̇ği̇t Yilmaz, Serkan Uysal, Ulaş Kumbasar, Zeynep Saribaş, Erkan Di̇kmen, Riza Doğan, Meti̇n Demi̇rci̇n

Turkish Journal of Medical Sciences

Background/aim: Significant advances have been achieved in immunotherapy for the treatment of lung cancer. It is known that tumor cells and cells in the tumor microenvironment express high amounts of programmed cell death ligand 1 (PD-L1). These PD-L1s interact with programmed cell death protein 1 (PD-1), causing immunosuppression. The aim of our study is to examine the correlation between the serum sPD-1 and sPD-L1 levels and clinicopathological characteristics in patients with nonsmall cell lung cancer. We also compared our results with the healthy population (control group). Materials and methods: Thirthy-seven nonsmall cell lung cancer (NSCLC) patients who were operated in …

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The Effect Of Immunonutrition On Tumor Infiltrative T Lymphocytes And Regulatory T Cells In Rectal Tumor Patients Receiving Neoadjuvant Chemoradiotherapy: A Prospective Randomized Clinical Study, Mehmet Onur Gül, Cebrai̇l Akyüz, Selvi̇naz Özkara Jan 2022

The Effect Of Immunonutrition On Tumor Infiltrative T Lymphocytes And Regulatory T Cells In Rectal Tumor Patients Receiving Neoadjuvant Chemoradiotherapy: A Prospective Randomized Clinical Study, Mehmet Onur Gül, Cebrai̇l Akyüz, Selvi̇naz Özkara

Turkish Journal of Medical Sciences

Background/aim: The rationale behind using immunonutrition in cancer patients is to prevent malnutrition, manage the host's immune response, and keep cancer under control by utilizing the potential immune system available in the host against the tumor. This prospective- study aims to assess the impact of immunonutrition on tumor-infiltrating lymphocytes (TILs) and regulatory T cells (Tregs) in rectal cancer patients receiving neoadjuvant chemoradiotherapy. Materials and methods: This is a single-center, prospective study. Forty patients diagnosed with middle and lower rectal tumors were enrolled in the study between March 2018 and December 2019. Nutrition protocols were given to all study subjects prior …

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Blood Neurofilament Light Chain And Thrombospondin-1 Levels Of Patients With Autism Spectrum Disorder, Cem Paketçi̇, Çağatay Ermi̇ş, Ali̇riza Şi̇şman, Semra Hiz, Burak Baykara, Uluç Yi̇ş Jan 2022

Blood Neurofilament Light Chain And Thrombospondin-1 Levels Of Patients With Autism Spectrum Disorder, Cem Paketçi̇, Çağatay Ermi̇ş, Ali̇riza Şi̇şman, Semra Hiz, Burak Baykara, Uluç Yi̇ş

Turkish Journal of Medical Sciences

Background/aim: Neurofilaments are intermediary filaments associated with neurodegenerative processes. Thrombospondin-1 (TSP1) is a biological marker playing a role in synaptogenesis. This study aimed to investigate serum neurofilament light chain (NFL), and TSP1 levels of patients with autism spectrum disorder (ASD) compared to typically developing (TD) children. Materials and methods: Forty-three patients with ASD and forty-five TD children were included. Serum biomarker levels were measured using the sandwich ELISA technique. The Childhood Autism Rating Scale (CARS) was implemented to measure the severity of ASD. Results: NFL and TSP1 levels did not differ between study groups (For NFL, ASD = 47.8 ± …

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Predictors Of Lymphovascular Invasion In Estrogen Receptor Positive/Her-2 Negative Breast Cancer Patients Treated With Neoadjuvant Chemotherapy, Eyyüp Çavdar, Yakup İri̇ağaç Jan 2022

Predictors Of Lymphovascular Invasion In Estrogen Receptor Positive/Her-2 Negative Breast Cancer Patients Treated With Neoadjuvant Chemotherapy, Eyyüp Çavdar, Yakup İri̇ağaç

Turkish Journal of Medical Sciences

Background/aim: Lymphovascular invasion (LVI) is considered a high-risk factor for recurrence in early-stage breast cancer, hence examination of LVI in pathological samples is an absolute recommendation. We aim to investigate predictive factors of LVI in preneoadjuvant chemotherapy (NAC) patients with estrogen receptor positive (ER+) and human epidermal growth factor receptor 2 negative (HER2-) molecular subtypes of breast cancer. Materials and methods: One hundred and thirty-four patients treated with NAC were included in this study who were ER+/HER2-. The clinical characteristics of the patients, the data obtained from the core needle biopsy before NAC and the LVI status in the pathology …

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Morbid Obesity Leads To Increased Skin Autofluorescence Independent Of Metabolic Syndrome Components, Tuğçe Apaydin, Di̇lek Yavuz Jan 2022

Morbid Obesity Leads To Increased Skin Autofluorescence Independent Of Metabolic Syndrome Components, Tuğçe Apaydin, Di̇lek Yavuz

Turkish Journal of Medical Sciences

Background/aim: Obesity, diabetes mellitus, and metabolic syndrome (MetS) are associated with increased accumulated skin advanced glycation end products. We aimed to evaluate the association of MetS components with skin autofluorescence (SAF) in patients with morbid obesity. Material and methods: Eight hundred and one patients with morbid obesity and 94 age-matched controls with normal body mass index (BMI) and normal glucose metabolism were included. Advanced glycation end products (AGEs) were measured using SAF in the forearm, with an AGE reader. Results: The prevalence of MetS in patients with morbid obesity was 65.5% (n = 525). Type 2 diabetes mellitus (type 2 …

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Could Lysosomal Acid Lipase Enzyme Activity Be Used For Clinical Follow-Up In Cryptogenic Cirrhosis?, Engi̇n Köse, Elçi̇n Çağatay, Tutku Yaraş Mercan, Peli̇n Teke Kisa, Semi̇nay Güler, Zümrüt Arslan Gülten, Mesut Akarsu, Yavuz Oktay, Hülya Ayar Kayali, Nur Arslan Jan 2022

Could Lysosomal Acid Lipase Enzyme Activity Be Used For Clinical Follow-Up In Cryptogenic Cirrhosis?, Engi̇n Köse, Elçi̇n Çağatay, Tutku Yaraş Mercan, Peli̇n Teke Kisa, Semi̇nay Güler, Zümrüt Arslan Gülten, Mesut Akarsu, Yavuz Oktay, Hülya Ayar Kayali, Nur Arslan

Turkish Journal of Medical Sciences

Background/aim: Cholesterol ester storage disease (CESD) is one of the rare causes that should be kept in mind in the etiology of cirrhosis. Recent studies detected that significantly reduced lysosomal acid lipase deficiency enzyme (LAL) in patients with cryptogenic cirrhosis (CC). Moreover, studies have evaluated that LAL activity is as effective as scoring systems in assessing the severity of cirrhosis. In this study, we aimed to investigate the CESD with LAL level and mutation analysis of LIPA gene in patients diagnosed with CC and to compare LAL activities between patients with CC and healthy volunteers. Materials and methods: Laboratory parameters …

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Are Disease-Related Symptoms Important To Predicting Developing Diabetes From Prediabetes?, Si̇bel Engi̇n, Tolga Akkan, Murat Dağdevi̇ren, Ti̇jen Şengezer, Mustafa Altay Jan 2022

Are Disease-Related Symptoms Important To Predicting Developing Diabetes From Prediabetes?, Si̇bel Engi̇n, Tolga Akkan, Murat Dağdevi̇ren, Ti̇jen Şengezer, Mustafa Altay

Turkish Journal of Medical Sciences

Background/aim: There are not many studies conducted to detect and recognize the symptoms during the prediabetes period. In our study, we aimed to determine the symptoms that can be seen in prediabetes and diabetes and their prevalence and to determine the similarities and differences between the two groups. Materials and methods: Individuals who were diagnosed with prediabetes or diabetes, over the age of 18, literate, and accepted to collaborate were included in our study. The "Diabetes Symptoms Checklist Scale" was used by interviewing 321 participants, 161 prediabetic and 160 diabetic, face-to-face. Results: It has been found that the most common …

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Optimal Screw Positioning In Cervical Pedicles To Avoid Complications, Kerem Atalar, Zafer Kutay Coşkun, Ahmet Memduh Kaymaz Jan 2022

Optimal Screw Positioning In Cervical Pedicles To Avoid Complications, Kerem Atalar, Zafer Kutay Coşkun, Ahmet Memduh Kaymaz

Turkish Journal of Medical Sciences

Background/aim: Cervical instability can be caused by a variety of factors, including trauma, tumors, or infection. The cervical transpedicular screw (CPS) is one of the most modern procedures for treating cervical instability. Despite the fact that numerous innovative techniques for CPS have been proposed, the appropriate screw entry points and screw directions have yet to be thoroughly established. The aim of this study is to determine the screw insertion angles and screw entry point distances based on reference points, pedicle axis lengths, and pedicle axis intersections for each vertebra from cervical (C) C2 to C7 in both right and left …

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The Clinical And Demographical Characteristics Of Turkish Pediatric Lymphedema Patients: A Multicenter Study, Pinar Borman, Ayşegül Balcan, Si̇bel Eyi̇gör, Evri̇m Coşkun, Fi̇kri̇ye Fi̇gen Ayhan, Burcu Duyur Çakit, Seçi̇l Vural, Meltem Vural, Esra Deni̇z Papatya Çakir, Deni̇z Nazi̇re Çağdaş Ayvaz, Ayşegül Yaman, Ayşe Beyhan Lale Cerrahoğlu, Sevi̇l Ceyhan Doğan Jan 2022

The Clinical And Demographical Characteristics Of Turkish Pediatric Lymphedema Patients: A Multicenter Study, Pinar Borman, Ayşegül Balcan, Si̇bel Eyi̇gör, Evri̇m Coşkun, Fi̇kri̇ye Fi̇gen Ayhan, Burcu Duyur Çakit, Seçi̇l Vural, Meltem Vural, Esra Deni̇z Papatya Çakir, Deni̇z Nazi̇re Çağdaş Ayvaz, Ayşegül Yaman, Ayşe Beyhan Lale Cerrahoğlu, Sevi̇l Ceyhan Doğan

Turkish Journal of Medical Sciences

Background/aim: Reducing lymphedema-associated burden and disability in the pediatric setting requires improved awareness and understanding clinical properties of the lymphedema. The aim of this study was to evaluate the clinical and demographic characteristics of patients with pediatric lymphedema presented to different lymphedema centers in Turkey. Materials and methods: The socio-demographic and clinical characteristics of the children including age, gender, presence of genetic syndromes, duration of edema, site and stage of lymphedema and the received therapies were determined. Parental and children education on self-management techniques were recorded. Results: A total of 122 children (female: 66, male: 56) with a mean age …

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Stable And Exacerbation Period Serum Cytokine And Periostin Levels Of The Five Distinct Phenotypes Of Severe Asthma, Murat Türk, İnsu Yilmaz, Selma Gökahmetoğlu, Ayşe Nedret Koç Jan 2022

Stable And Exacerbation Period Serum Cytokine And Periostin Levels Of The Five Distinct Phenotypes Of Severe Asthma, Murat Türk, İnsu Yilmaz, Selma Gökahmetoğlu, Ayşe Nedret Koç

Turkish Journal of Medical Sciences

Background/aim: The differences in molecular mechanisms during a stable period and the changes in the inflammatory responses during exacerbations between distinct severe asthma phenotypes remain unclear. In this study, we aimed to characterize stable and exacerbation period serum cytokine and periostin levels of 5 different predefined severe asthma phenotypes with real-life data. Changes in the viral infection-induced exacerbations were also analyzed. Materials and methods: Serum levels of 8 cytokines and periostin were measured from the sera obtained from the adult patients with five different severe asthma phenotypes based on the presence/absence of aeroallergen sensitivity, peripheral eosinophilia and chronic rhinosinusitis with …

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The Validity And Clinical Utility Of Axillary Ultrasonography-Guided Fine Needle Aspiration Biopsy In Detection Of Nodal Metastasis In Early-Stage Breast Cancer Patients: A Retrospective Single-Center Experience, Fi̇li̇z Taşçi, Yavuz Meti̇n, Nurgül Orhan Meti̇n, Maksude Esra Kadioğlu, Meli̇h Gaffar Gözükara, Si̇bel Kul Jan 2022

The Validity And Clinical Utility Of Axillary Ultrasonography-Guided Fine Needle Aspiration Biopsy In Detection Of Nodal Metastasis In Early-Stage Breast Cancer Patients: A Retrospective Single-Center Experience, Fi̇li̇z Taşçi, Yavuz Meti̇n, Nurgül Orhan Meti̇n, Maksude Esra Kadioğlu, Meli̇h Gaffar Gözükara, Si̇bel Kul

Turkish Journal of Medical Sciences

Background/aim: Assessing the validity and clinical utility of axillary ultrasonography (AUS)-guided fine needle aspiration biopsy (FNAB) in detection of nodal metastasis during preoperative axillary investigation in comparison to the histopathologic diagnosis in early-stage breast cancer. Materials and methods: A total of 279 operated primary breast cancer patients (age: 55.3 ± 12.8, ranged 17-90 years) were included. Data on AUS findings at the time of initial diagnosis (first look AUS), second-look AUS findings performed by the breast radiologist during breast biopsy procedure and the AUS-guided FNAB findings were evaluated with respect to the final histopathology report obtained through axillary surgery via …

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Length-Weight Relationships Of 28 Fish Species Caught From Demersal Trawl Survey In Themiddle Black Sea, Turkey, Murat Dağteki̇n, Yaşar Genç, Nazli Kasapoğlu, Gökhan Eri̇k, Devri̇m Seli̇m Misir, Sali̇h İlhan, Meltem Ok, Cemi̇l Altuntaş, Uğur Özsandikçi, Ferhat Büyükdeveci̇, Tuğba Kaya, Ayşe Cebeci̇, Asi̇ye Nur Saltan, Ati̇la Haşi̇moğlu, Şi̇ri̇n Fi̇ri̇di̇n Jan 2022

Length-Weight Relationships Of 28 Fish Species Caught From Demersal Trawl Survey In Themiddle Black Sea, Turkey, Murat Dağteki̇n, Yaşar Genç, Nazli Kasapoğlu, Gökhan Eri̇k, Devri̇m Seli̇m Misir, Sali̇h İlhan, Meltem Ok, Cemi̇l Altuntaş, Uğur Özsandikçi, Ferhat Büyükdeveci̇, Tuğba Kaya, Ayşe Cebeci̇, Asi̇ye Nur Saltan, Ati̇la Haşi̇moğlu, Şi̇ri̇n Fi̇ri̇di̇n

Turkish Journal of Zoology

This study provides updated the length-weight relationships and Fulton's condition factor of 28 fish species belonging to 23 families from the Black Sea. Samples were collected along the depths between 0-100 meters by demersal trawl surveys conducted seasonally from May 2017 to September 2019. A total of 83,885 specimens were collected. The length-weight relationships and Fulton's condition factor, minimum, maximum and mean lengths, total weights, descriptive statistics, and growth type were provided for all the species. The results indicate that LWR parameters of b varied from 2.2039 to 3.737 and Fulton's condition factor varied between 0.004 and 1.18. These findings …

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A Review Of The Alien Fishes Of Turkish Inland Waters, Erdoğan Çi̇çek, Soheil Eagderi, Sevi̇l Sungur Jan 2022

A Review Of The Alien Fishes Of Turkish Inland Waters, Erdoğan Çi̇çek, Soheil Eagderi, Sevi̇l Sungur

Turkish Journal of Zoology

Aquaculture, recreational fishing, restocking, biological control, and the ornamental fish trade have increased the number of nonnative fish in Turkish inland waters. This work reviews the history, current state, and tendencies of fish introductions into Turkish freshwaters. To date, it is known that a total of 34 exotic species (except two marine and three misidentified species) have been introduced deliberately or accidentally into Turkish inland waters, of which, only 19 species have been established in wild ecosystems. A total of five acclimatized species, viz. Coregonus lavaretus, C. macrophthalmus, Salmo salar, Salvelinus alpinus, and S. fontinalis and four species, viz. Hypophthalmichthys …

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Clinical Applications Of Internal Fixation Via The Volar Approach With Pronator Quadratus Preservation For Distal Radius Fractures, Jie Zhong, Xiaohui Li, Fuxin Lv, Naiyue Cao, Dangke Li Jan 2022

Clinical Applications Of Internal Fixation Via The Volar Approach With Pronator Quadratus Preservation For Distal Radius Fractures, Jie Zhong, Xiaohui Li, Fuxin Lv, Naiyue Cao, Dangke Li

Turkish Journal of Medical Sciences

Background/aim: The purpose of this study is to investigate the success rate of volar plate treatment of distal radius fractures with preservation of the pronator anterior muscle; the incidence of complications, such as infection, vascular nerve injury, and tendon injury; fracture healing rate; and changes in muscle anatomy. Materials and methods: The Henry approach was adopted to treat distal radius fractures with pronator quadratus (PQ) preservation on a trial basis. Between June 2015 and January 2017, 46 cases of distal radius fractures were considered according to the Arbeitsgemeinschaft für Osteosynthesefragen (AO) classification. The PQ was preserved, the distal margin was …

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Surgical Outcomes Of Extraskeletal Myxoid Chondrosarcoma, Coşkun Ulucaköy, İsmai̇l Burak Atalay, Ali̇ekber Yapar, Ahmet Yi̇ği̇t Kaptan, İzzet Bi̇ngöl, Mehmet Doğan, Mehmet Fati̇h Ekşi̇oğlu Jan 2022

Surgical Outcomes Of Extraskeletal Myxoid Chondrosarcoma, Coşkun Ulucaköy, İsmai̇l Burak Atalay, Ali̇ekber Yapar, Ahmet Yi̇ği̇t Kaptan, İzzet Bi̇ngöl, Mehmet Doğan, Mehmet Fati̇h Ekşi̇oğlu

Turkish Journal of Medical Sciences

Background/aim: Extraskeletal myxoid chondrosarcoma (EMC) is a rare soft tissue sarcoma. The aim of this study is to present the results of the patients we treated with the diagnosis of EMC as an oncology reference center. Materials and methods: Information on 13 patients diagnosed with EMC between 2006 and 2018 was retrospectively reviewed. Patients' demographic information, tumor sizes, surgical treatments, chemotherapy and radiotherapy statuses, follow-up times, recurrences, and metastases were recorded. Results: Mean patient age was 53.6 ± 15 years (range: 28-73). In 8 patients, the tumor was located in the lower limbs, most commonly in the thigh (46.2%). Mean …

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A Single-Center Experience Of Magnetic Resonance Imaging Findings Of Fetal Sacrococcygeal Teratomas, Mesude Tosun, İsa Çam, Hande Uslu, Yasemi̇n Doğan, Yonca Anik Jan 2022

A Single-Center Experience Of Magnetic Resonance Imaging Findings Of Fetal Sacrococcygeal Teratomas, Mesude Tosun, İsa Çam, Hande Uslu, Yasemi̇n Doğan, Yonca Anik

Turkish Journal of Medical Sciences

Background/aim: Sacrococcygeal teratomas (SCT) are known as rare tumors, but they are the most common tumor in fetuses and newborns. This study aims to present fetal magnetic resonance imaging (MRI) findings of SCT diagnosed prenatally and compare them with that of the prenatal Ultrasound (US) findings. Materials and methods: Eleven patients diagnosed as SCT prenatally by US and further assessed by MRI are included. MRI was performed via a 1.5-T magnet with a body coil. The presence, size, content extension, and compressive effects of each mass were determined and correlated with US findings and with postnatal examinations, including surgery and …

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Evaluation Of The Relationship Between Vitamin D Level And Adropin, Il-1ss, Il-6, And Oxidative Status In Women, Mehmet Zorlu, Abdüsselam Şekerci̇, Muhammed Tunç, Eray Meti̇n Güler, Bedi̇a Gülen, Cumali̇ Karatoprak, Muharrem Kiskaç, Mustafa Çakirca Jan 2022

Evaluation Of The Relationship Between Vitamin D Level And Adropin, Il-1ss, Il-6, And Oxidative Status In Women, Mehmet Zorlu, Abdüsselam Şekerci̇, Muhammed Tunç, Eray Meti̇n Güler, Bedi̇a Gülen, Cumali̇ Karatoprak, Muharrem Kiskaç, Mustafa Çakirca

Turkish Journal of Medical Sciences

Background/aim: Vitamin D, adropin, proinflammatory cytokines, and oxidative stress closely related with metabolic homeostasis and endothelial dysfunction. The aim of the present study is to investigate how vitamin D levels affect serum adropin, IL-1ß, IL-6, and oxidative stress. Materials and methods: A total of 77 female subjects were divided into 3 groups according to vitamin D levels. Biochemical parameters, adropin, IL-1ß, IL-6, oxidative stress markers were studied in these groups, and the results were compared statistically. Results: Serum adropin, IL-1ß, IL-6, total oxidant status (TOS) and total antioxidant status (TAS) and oxidative stress index (OSI) levels differed significantly between the …

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Marine Mucilage In The Sea Of Marmara And Its Effects On The Marine Ecosystem: Mass Deaths, Uğur Karadurmuş, Mustafa Sari Jan 2022

Marine Mucilage In The Sea Of Marmara And Its Effects On The Marine Ecosystem: Mass Deaths, Uğur Karadurmuş, Mustafa Sari

Turkish Journal of Zoology

In April of 2021, there was a massive explosion of marine mucilage in the Sea of Marmara, as a result, many invertebrates of marine communities suffered mass mortality. We summarize our results about the devastating effect of mucilage bloom on mass deaths in the Sea of Marmara. The phenomena were lethal to the pelagic fishes and crustaceans, and individuals were impacted severely smothered by mucilage or anoxia. Mucilage accumulations have shown their effectiveness in many areas around the Kapıdağ Peninsula. Misakça, Şirinçavuş, Narlı, and Tatlısu regions, where mass death cases occurred, were selected as study areas, and these areas are …

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Factors Associated With Treatment Success After Combined Transforaminal Epidural Steroid Injection And Dorsal Root Ganglion Pulsed Radiofrequency Treatment In Patients With Chronic Lumbar Radicular Pain, Gülçi̇n Gazi̇oğlu Türkyilmaz Jan 2022

Factors Associated With Treatment Success After Combined Transforaminal Epidural Steroid Injection And Dorsal Root Ganglion Pulsed Radiofrequency Treatment In Patients With Chronic Lumbar Radicular Pain, Gülçi̇n Gazi̇oğlu Türkyilmaz

Turkish Journal of Medical Sciences

Background/aim: The aim of the study is to identify predictors of treatment success with combined transforaminal epidural steroid injection (TFESI) and dorsal root ganglion pulsed radiofrequency (DRG-PRF) in patients with lumbar radicular pain (LRP) associated with lumbar disc herniation. Materials and methods: The study included 48 patients with herniation-related LRP who underwent TFESI and DRG-PRF treatment between November 1, 2020 and April 30, 2021. Patient age, sex, symptom duration, history of lumbar surgery, and numeric rating scale (NRS) pain scores before and at 10 days, 1 month, and 3 months after treatment were evaluated retrospectively. Treatment success was defined as …

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Correlations Between Glycosylated Hemoglobin And Glucose Levels In Chinese Older Adults With Newly Diagnosed Type 2 Diabetes Mellitus, Yun Yu, Jun Yang, Wei Tang Jan 2022

Correlations Between Glycosylated Hemoglobin And Glucose Levels In Chinese Older Adults With Newly Diagnosed Type 2 Diabetes Mellitus, Yun Yu, Jun Yang, Wei Tang

Turkish Journal of Medical Sciences

Background/aim: To explore the correlations between glycosylated hemoglobin (HbA1c) and glucose levels in older adults with newly diagnosed type 2 diabetes mellitus (T2DM). Materials and methods: A total of 783 participants aged ≥60 years were enrolled. The 75-g oral glucose tolerance test (OGTT) was conducted and HbA1c was measured. The participants were divided into normal glucose tolerance (NGT)HbA1c, Pre-DMHbA1c, and T2DMHbA1c groups based on the HbA1c diagnostic criteria. The correlations between HbA1c and glucose levels of the OGTT were analyzed. Results: When HbA1c ≥ 6.5% in older people, HbA1c was positively correlated with Glucose 0 min and 120 min of …

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Density, Diversity, And Seasonal Fluctuations In Soil Collembola In Three Differentlymanaged Ecosystems In North Khorasan, Iran, Mahmood Mehrafrooz Mayvan, Hussein Sadeghi Namaghi, Masoumeh Shayanmehr, Penelope Greenslade, Grant Palmer Jan 2022

Density, Diversity, And Seasonal Fluctuations In Soil Collembola In Three Differentlymanaged Ecosystems In North Khorasan, Iran, Mahmood Mehrafrooz Mayvan, Hussein Sadeghi Namaghi, Masoumeh Shayanmehr, Penelope Greenslade, Grant Palmer

Turkish Journal of Zoology

We examined the density, diversity, and seasonal fluctuation of soil inhabiting Collembola in different ecosystems: agricultural, rangeland, and forest ecosystems in the North Khorasan province of Iran from June 2018 to May 2019. The sampling program was conducted monthly on the three sites. Density was measured on the number of individuals per square meter. Species diversity was calculated using Shannon?Wiener index, Simpson?s diversity, and species richness by Rarefaction method. Fifty-three species belonging to 42 genera and 17 families were collected and identified. The density of Collembola in the forest was higher than in either rangeland or agroecosystem. Highest densities were …

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The Clinical, Pathological, And Genetic Characteristics Of Lipid Storage Myopathy In Northern China, Jingzhe Han, Shan Lu, Xueqin Song, Guang Ji, Yanan Xie, Hongran Wu Jan 2022

The Clinical, Pathological, And Genetic Characteristics Of Lipid Storage Myopathy In Northern China, Jingzhe Han, Shan Lu, Xueqin Song, Guang Ji, Yanan Xie, Hongran Wu

Turkish Journal of Medical Sciences

Background/aim: The lipid storage myopathy (LSM) diagnosis is based on the patient's clinical manifestations and muscle pathology. However, when genetic testing is lacking, there is a high rate of misdiagnosis of the disease. This study aimed to investigate the clinical and pathological features of genetically diagnosed LSM in northern China, analyze genetic mutations' characteristics, and improve the LSM diagnostic rate. Materials and methods: Twenty patients with LSM diagnosed were collected; meanwhile, the clinical data, muscle samples, and routine pathological staining of muscle specimens were collected. The morphological changes of muscle fibers were observed under an optical microscope. Results: Among the …

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Venom Immunotherapy And Difficulties Encountered Before And During Immunotherapy: Double Sensitization, Systemic Reactions, Treatment With Omalizumab, And High Dose Vit, Gülden Paçaci Çeti̇n, İnsu Yilmaz, Murat Türk, Bahar Arslan, Saki̇ne Nazi̇k Bahçeci̇oğlu Jan 2022

Venom Immunotherapy And Difficulties Encountered Before And During Immunotherapy: Double Sensitization, Systemic Reactions, Treatment With Omalizumab, And High Dose Vit, Gülden Paçaci Çeti̇n, İnsu Yilmaz, Murat Türk, Bahar Arslan, Saki̇ne Nazi̇k Bahçeci̇oğlu

Turkish Journal of Medical Sciences

Background/aim: Venom immunotherapy (VIT) is the most effective treatment method to prevent recurrent systemic reactions to Hymenoptera stings. In this study, the demographic characteristics of VIT patients, the success rates of VIT, the difficulties we encountered during VIT, and solutions for these difficulties in our clinic were presented. Materials and methods: We retrospectively analyzed patients with venom allergy who applied venom immunotherapy between 2013- 2020. Data on age, gender, Hymenoptera species with the first reaction, grade of the reaction, beekeeping history, skin prick and specific IgE and component results, double sensitization, blood groups, and reactions with VIT and/or sting during …

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Cerebrospinal Fluid Level Of Neurofilament Light Chain Is Associated With Increased Disease Activity In Neuro-Behçet's Disease, Zerri̇n Karaaslan, Eli̇f Şanli, Özlem Ti̇mi̇rci̇ Kahraman, Vuslat Yilmaz, Ece Akbayir, Gi̇zem Koral, Sema İçöz, Tuncay Gündüz, Cem İsmai̇l Küçükali̇, Murat Kürtüncü, Erdem Tüzün Jan 2022

Cerebrospinal Fluid Level Of Neurofilament Light Chain Is Associated With Increased Disease Activity In Neuro-Behçet's Disease, Zerri̇n Karaaslan, Eli̇f Şanli, Özlem Ti̇mi̇rci̇ Kahraman, Vuslat Yilmaz, Ece Akbayir, Gi̇zem Koral, Sema İçöz, Tuncay Gündüz, Cem İsmai̇l Küçükali̇, Murat Kürtüncü, Erdem Tüzün

Turkish Journal of Medical Sciences

Background/aim: Clinical exacerbations characterized with neurological symptoms are observed in around 10% of Behçet's disease (BD) patients and may culminate in severe disability. Although certain immunological factors have been associated with disease activity in neuro-Behçet's disease (NBD), biomarkers for monitoring the clinical outcome of NBD have not been properly investigated. Materials and methods: Levels of neurofilament light chain (NFL), homeobox protein Hox-B3 (HoxB3), and YKL-40 were measured in cerebrospinal fluid (CSF) samples of 23 parenchymal (n = 16) and nonparenchymal (n = 7) NBD patients obtained during NBD attacks by ELISA. Parameters of clinical progression and outcome were assessed for …

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Hematological Status Of Avian Species Along A Metal Pollution Gradient At Sialkot, Pakistan, Ajmal Shehzad, Khalid Mahmood Anjum, Atif Yaqub, Muhammad Zubair Yousaf, Sarwr Allah Ditta, Junaid Naseer Jan 2022

Hematological Status Of Avian Species Along A Metal Pollution Gradient At Sialkot, Pakistan, Ajmal Shehzad, Khalid Mahmood Anjum, Atif Yaqub, Muhammad Zubair Yousaf, Sarwr Allah Ditta, Junaid Naseer

Turkish Journal of Zoology

The concentration of metals and effects of these metals on hematological parameters were examined in avian species by using feathers and blood samples collected from different sites of Sialkot. The major reason for significant differences in hematological parameters and concentrations of metal contents between different species was the difference in feeding habitat. Metal concentrations in feathers and blood samples indicated that the chromium and lead were not found at a safe level. The results did not revealed a significant negative association between metal contents and hematological parameters but concluded that increased metal contents exert negative effects on hematological status especially …

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Percutaneous Transhepatic Management Of Biliary Strictures In Patients With Dysfunctioning Plastic Biliary Endoprostheses, Umut Öğüşlü, Gürkan Danişan, Burçak Gümüş Jan 2022

Percutaneous Transhepatic Management Of Biliary Strictures In Patients With Dysfunctioning Plastic Biliary Endoprostheses, Umut Öğüşlü, Gürkan Danişan, Burçak Gümüş

Turkish Journal of Medical Sciences

Background/aim: To evaluate the safety and outcomes of percutaneous transhepatic management of dysfunctioning plastic biliary endoprostheses (PBE) in patients with benign/malign biliary strictures. Materials and methods: Twenty-nine patients (22 men, 7 women; mean age of 60.7 (range 33-88) years) diagnosed with dysfunctioning PBE were included. Percutaneous transhepatic biliary drainage and subsequent PBE dislodgment into the bowel were performed in all cases. Patient demographics, etiology of the biliary stricture, indication, technical success, complications, and clinical outcomes were gleaned from medical records. Results: Seventeen patients had malignant strictures, while 12 patients had benign conditions. A total of 36 PBE (33 straight, 3 …

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Comparison Of Two Different Minimally Invasive Techniques Used In Bladder Stone Surgery For Preschool-Aged Children, İsmai̇l Yağmur, Mehmet Demi̇r, Bülent Kati, Eyyup Sabri̇ Peli̇t, Eser Ördek, Hali̇l Çi̇ftçi̇ Jan 2022

Comparison Of Two Different Minimally Invasive Techniques Used In Bladder Stone Surgery For Preschool-Aged Children, İsmai̇l Yağmur, Mehmet Demi̇r, Bülent Kati, Eyyup Sabri̇ Peli̇t, Eser Ördek, Hali̇l Çi̇ftçi̇

Turkish Journal of Medical Sciences

Background/aim: This study was designed to compare the outcomes of mini-percutaneous cystolithotomy (mPCL) and transurethral cystolithotripsy (TUCL) in treating bladder stones in preschool-aged children (≤6 years old). Materials and methods: Twenty-four patients treated with mPCL and 28 patients treated with TUCL for bladder stones were compared retrospectively. The operative and postoperative outcomes of both groups were analyzed. Results: The mean age and gender distribution were similar between the groups. The mean stone size was 16.5 ± 0.5 mm for the mPCL group and 14.9 ± 5.7 mm for the TUCL group (p = 0.318). The mean operative time was 41.1 …

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Evolution Of Clinically Isolated Syndrome To Pediatric-Onset Multiple Sclerosis And A Review Of The Literature, İsmai̇l Solmaz, İbrahi̇m Hali̇l Öncel Jan 2022

Evolution Of Clinically Isolated Syndrome To Pediatric-Onset Multiple Sclerosis And A Review Of The Literature, İsmai̇l Solmaz, İbrahi̇m Hali̇l Öncel

Turkish Journal of Medical Sciences

Background/aim: Clinically isolated syndrome (CIS) may be the first presentation of pediatric onset multiple sclerosis (POMS). We retrospectively evaluated the clinical and laboratory data of pediatric CIS (pCIS) patients who were diagnosed with POMS upon followup for any predictive variables. We also reviewed the literature concerning the management of pCIS. Materials and methods: This single-center study involved patients who had pCIS in childhood that converted to POMS during followup between 2011 and 2021. Sixteen patients were included in the study. The data were evaluated retrospectively and analyzed with descriptive statistics. Results: The majority of the pCIS patients were female (F/M: …

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Egfr Blocker Lapatinib Inhibits The Synthesis Of Matrix Metalloproteinases From Synovial Fibroblasts, Demet Yalçin Kehri̇bar, Hakan Emmungi̇l, Neşe Başak Türkmen, Osman Çi̇ftçi̇, Emi̇ne Şalva, Meti̇n Özgen Jan 2022

Egfr Blocker Lapatinib Inhibits The Synthesis Of Matrix Metalloproteinases From Synovial Fibroblasts, Demet Yalçin Kehri̇bar, Hakan Emmungi̇l, Neşe Başak Türkmen, Osman Çi̇ftçi̇, Emi̇ne Şalva, Meti̇n Özgen

Turkish Journal of Medical Sciences

Background/aim: Epidermal growth factor receptor (EGFR) family members and their associated ligands may be related to bone and joint destruction in rheumatoid arthritis. Matrix metalloproteinases are responsible for joint and bone tissue degradation. This study is intended to investigate the effect of epidermal growth factor receptor inhibition by lapatinib on the synthesis of matrix metalloproteinases in in vitro. Materials and methods: Synovial fibroblast cell culture was obtained from a patient with rheumatoid arthritis who underwent knee arthroplasty. Interleukin-1ß (IL-1ß) and tumor necrosis factor-∝ (TNF-∝) were added to the cell culture to stimulate synovial fibroblast cells and create an inflammatory character. …

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