Digital Commons Network^™

Defective Dna Polymerase Beta Invoke A Cytosolic Dna Mediated Inflammatory Response, Shengyuan Zhao, Julia A Goewey Ruiz, Manu Sebastian, Dawit Kidane

Faculty, Staff and Student Publications

Base excision repair (BER) has evolved to maintain the genomic integrity of DNA following endogenous and exogenous agent induced DNA base damage. In contrast, aberrant BER induces genomic instability, promotes malignant transformation and can even trigger cancer development. Previously, we have shown that deoxyribo-5'-phosphate (dRP) lyase deficient DNA polymerase beta (POLB) causes replication associated genomic instability and sensitivity to both endogenous and exogenous DNA damaging agents. Specifically, it has been established that this loss of dRP lyase function promotes inflammation associated gastric cancer. However, the way that aberrant POLB impacts the immune signaling and inflammatory responses is still unknown. Here …

Trending Tubes: A Social Media Analysis Of Tympanostomy Tubes In Children, Nicholas A Rossi, Katherine R French, Chad L Evans, Jason F Ohlstein, Luis D Neve, Shiva Daram, Dayton L Young, Brian J Mckinnon, Harold S Pine

Faculty, Staff and Student Publications

OBJECTIVE: To investigate the popular social media platforms Instagram and Facebook for public posts related to tympanostomy tubes in children, to discern attitudes and perceptions surrounding tympanostomy tubes, and to evaluate the content of social media posts related to tympanostomy tubes.

STUDY DESIGN: Qualitative study.

SETTING: Instagram and Facebook social media platforms.

METHODS: Instagram and Facebook were searched for public posts from 2018 and 2019 including the search terms "ear tubes,""ear tube surgery,""tympanostomy," and "myringotomy." Posts were excluded if they were unrelated to pediatric tympanostomy tubes or written in a non-English language. Relevant posts underwent subgroup analysis based on 6 …

2022 Morehead State University Benefits Guide, Morehead State University. Office Of Human Resources.

Staff Congress Records

2022 Morehead State University Benefits Guide.

Biodiversity In Residential Yards For Sustainability In Small Cities: Understanding Public Attitudes, Opportunities And Limitations In Vermillion, Sd, Rina Thapa

Dissertations and Theses

As urban areas are expanding with the growing size of human population, it is increasingly important to understand the role that residential yards can play in biodiversity conservation because they often comprise a large proportion of green spaces in cities. Most of the research performed to date on the role of residential yards in biodiversity conservation has been conducted in large cities. The role of residential yards in biodiversity conservation in small cities is still largely unknown. In this research, I discuss the relationship between biodiversity and the structure of green space, public attitudes towards the presence of wildlife, public …

Exposition Des Travailleurs Aux Particules Ultrafines Et Aux Composés Organiques Volatils Émis Lors D’Un Processus D’Impression 3d : État Des Lieux Au Québec, Mohamed Zemzem, Ludwig Vinches, Stéphane Hallé

États de la question, rapports d’expertise et revues de littérature

Deux revues de la littérature ont été entreprises dans le but de collecter un maximum d’informations sur la fabrication additive (ou impression 3D) et ses implications dans le milieu du travail. Elles visent plus spécifiquement à : 1) identifier l’ensemble des techniques utilisées en impression 3D ainsi que les matériaux qui leur sont associés, mais aussi les différents champs d’application et les activités professionnelles concernées; 2) mettre en évidence les taux d’émissions de particules ultrafines (PUF) et de composés organiques volatils (COV) lors d’un processus d’impression 3D et 3) dégager les principaux paramètres d’utilisation des imprimantes, pouvant influencer les émissions …

Evaluating A Pilot Culturally Sensitive Psychosocial Intervention On Posttraumatic Growth For Chinese American Breast Cancer Survivors, Qiao Chu, Moni Tang, Lingjun Chen, Lucy Young, Alice Loh, Carol Wang, Qian Lu

Faculty, Staff and Student Publications

This study investigated the potential benefit of a pilot culturally sensitive group support intervention, named Joy Luck Academy (JLA), in fostering posttraumatic growth among Chinese American breast cancer survivors. Eighty-six Chinese American breast cancer survivors participated in an eight-week single-arm pre-/post-test trial of an intervention program, which included educational lectures and peer mentor support. The JLA participants were compared with an independent sample of 109 Chinese American breast cancer survivors who went through routine care. Both groups completed baseline and eight-week follow-up assessments of the five facets of posttraumatic growth (meaningful interpersonal relationships, finding new possibilities in life, personal strength, …

Quaking But Not Parkin Is The Major Tumor Suppressor In 6q Deleted Region In Glioblastoma, Fatma Betul Aksoy Yasar, Takashi Shingu, Daniel B Zamler, Mohammad Fayyad Zaman, Derek Lin Chien, Qiang Zhang, Jiangong Ren, Jian Hu

Faculty, Staff and Student Publications

Glioblastoma (GBM) is a high-grade, aggressive brain tumor with dismal median survival time of 15 months. Chromosome 6q (Ch6q) is a hotspot of genomic alterations, which is commonly deleted or hyper-methylated in GBM. Two neighboring genes in this region, QKI and PRKN have been appointed as tumor suppressors in GBM. While a genetically modified mouse model (GEMM) of GBM has been successfully generated with Qk deletion in the central nervous system (CNS), in vivo genetic evidence supporting the tumor suppressor function of Prkn has not been established. In the present study, we generated a mouse model with Prkn-null allele …

Update On Mri In Evaluation And Treatment Of Endometrial Cancer, Ekta Maheshwari, Stephanie Nougaret, Erica B Stein, Gaiane M Rauch, Ken-Pin Hwang, R Jason Stafford, Ann H Klopp, Pamela T Soliman, Katherine E Maturen, Andrea G Rockall, Susanna I Lee, Elizabeth A Sadowski, Aradhana M Venkatesan

Faculty, Staff and Student Publications

Endometrial cancer is the second most common gynecologic cancer worldwide and the most common gynecologic cancer in the United States, with an increasing incidence in high-income countries. Although the International Federation of Gynecology and Obstetrics (FIGO) staging system for endometrial cancer is a surgical staging system, contemporary published evidence-based data and expert opinions recommend MRI for treatment planning as it provides critical diagnostic information on tumor size and depth, extent of myometrial and cervical invasion, extrauterine extent, and lymph node status, all of which are essential in choosing the most appropriate therapy. Multiparametric MRI using a combination of T2-weighted sequences, …

Brown Bag Webinar At The Tmc Library, Beatriz Varman

TMC Library Newsletter (2015-)

The TMC Library is Offering the Following "Brown Bag" Webinar. The McGovern Historical Center & Me: Thinking about Archives and Legacies. If you only have 30 minutes to spare, join us for this virtual webinar. Everyone who registers, will receive a Zoom link to join the webinar.

The Level Of Accessibility Of Inclusive Design Of Christian Temples And Churches In Ukraine, Olga Polumysna, Oktyabrina Chemakina, Valeriy Bulatov

Occasional Papers on Religion in Eastern Europe

The article explores the issues of accessibility of inclusive design of Christian churches in Ukraine. The principle of accessibility as the main element of inclusive design often causes a conflict of interests in modern Ukrainian society, as it requires changes in the existing state of affairs. To make the subject-spatial environment accessible not only in everyday life, production, but also in the Christian sacred environment is one of the primary tasks of inclusive design. Many Christian churches in Ukraine are not ready to accept people with inclusion since the conditions of accessibility are not met. One of the reasons is …

Training Of Military Chaplains For The Armed Forces Of Ukraine In Conditions Of The Invasion By The Russian Federation, Bogdan Synchak, Petro Livak, Mykhailo Fedorenko

Occasional Papers on Religion in Eastern Europe

The article analyzes the comprehensive training of military chaplains for the Armed Forces of Ukraine. The legislative basis of chaplaincy, and the methods and state of its implementation are characterized. The problems that can befall a military chaplain are identified, in particular the contradiction in the combination of military service and pacifism. The development of chaplaincy in Ukraine is outlined. Active assistance to the chaplaincy began only after the Orange Revolution (2004-2005). The following year, a legislative act was made through the directive “On streamlining issues of meeting the religious needs of the military personnel of the Armed Forces of …

Medication Errors: Causes, Theories And Interventions, Tuyba Karim

Master of Science in Nursing Family Nurse Practitioner

Rationale, aims and objectives: Following heart disease and cancer, medication errors rank third as the leading cause of death in the United States. For the primary care provider, the root causes of medication errors stem from multiple factors. To improve positive learning outcomes for primary care providers in reducing medication errors, this project sets out to examine the utility of educational interventions in improving the present standard of care as it relates to medication error safety and patient outcomes.

Methods: A literature review was conducted analyzing recent studies that examined the use of educational interventions in promoting positive learning outcomes …

Multimodal Medicine: Pain Control Potential, Tyler Ostlund

Master of Science in Nursing Family Nurse Practitioner

Due to the continual problem with overuse of, overdose on, and abuse of opioid medications for the past three decades it is paramount that effective, cheap, and above all safe forms of pain control are studied and applied. Multimodal pain management utilizes a combination of pharmacological and non pharmacological therapies in synergy to control pain and reduce dependence on strictly opioids. Combining the effects of medications or therapies that focus on treating different types or sources of pain such as inflammatory pain, neurological pain, etc. With the adoption of this method of pain management, the longstanding effects of the opioid …

The Use Of Distraction Techniques During Painful Procedures In Pediatric Patients, Bethany Hayward

Master of Science in Nursing Family Nurse Practitioner

No abstract provided.

Clergy Social Activity During War Conditions: The Case Of Western Regions Of Ukraine, Ihor Lutsan, Iryna Horokholinska

Occasional Papers on Religion in Eastern Europe

In this article, the authors analyze the impact of Russia-Ukraine war on church-religious life and the state of public consciousness in Ukraine and identify the main trends and contradictions in public reactions to threats to their lives and spirituality. The research focuses on religious communities of the western regions of Ukraine and their socially significant activities. The primary empirical source of the article was the study (by questionnaire survey) of the opinions of the clergy of this religious organization on the characteristics of parish life and the role of the pastor in the conditions of war. Three defining vectors that …

The Slater Fire Was The Product Of Settler Colonialism, William Joseph Curtis

Cal Poly Humboldt theses and projects

The Slater Fire of 2020 burned in Karuk aboriginal territory overseen by the Klamath National Forest. It burned over 200 homes to the ground and ravage over 100,000 acres of forest. This thesis argues that state-enforced fire suppression policies and methods are tools of settler-colonial erasure and the continuation of genocidal violence towards Karuk people. It analyzes the conflict between interests of the colonial state on one side and Indigenous resistance and survival on the other. Fire is an essential tool for the survival of Indigenous cultural identities, the material security of said populations, and the health of the environs …

Assessing The Potential And Pathways For Renewable Energy Transformations In Orleans, California, Malcolm Prescott Moncheur De Rieudotte

Cal Poly Humboldt theses and projects

In what is now known as the state of California in the United States, the Karuk Tribe is interested in deploying a renewable-powered microgrid in the rural community of Orleans to improve electricity system reliability and resilience to address a wide range of challenges, including extreme events such as wildfires. This study assesses the potential of local distributed renewable energy and battery storage to meet Orleans' energy needs today and in the increasingly electrified future using an energy model. It also identifies existing cultural and social priorities for energy technology along with structural barriers to renewable energy adoption and the …

Evaluating Relative Abundance, Fish Length, And Marine Protected Area Effectiveness For Four Key Rocky Reef Species Along The Northern Californian Coast, Leon Davis

Cal Poly Humboldt theses and projects

Marine protected areas (MPAs) were created with the purpose of helping conserve and restore diminished populations of marine organisms. Measuring the effectiveness of MPAs requires long-term monitoring, investigating the abundance and size distributions of the species that utilize the conservation areas, and comparing the results to neighboring reference sites that are not currently protected. In this study, observations from long-term MPA monitoring in northern California (2010-2019) were modeled with substrate, oceanographic, spatial, temporal, and body size variables to describe the variability in abundance and size of three fish groups: Black rockfish (Sebastes melanops), the Blue rockfish group (comprised …

From The Edge Of A Rib: Pro-Ana Edgeworking Narratives, Casey Dobbins

Cal Poly Humboldt theses and projects

People who deliberately practice eating disordered behaviors as a lifestyle form digital communities known as pro-ana. Pro-ana identity is constructed through the medicalized frameworks of anorexia nervosa that attempt to maximize weight loss and also manage other eating disorder behaviors such as binging and purging. This thesis examines pro-ana materials requested and produced on websites, Whisper, and Reddit, assembling these discursive and image exchanges into discourses that identify and describe eating disorder pathology and recovery. My ethnographic collection consists of screenshots of written materials and images from websites, Whisper posts, Reddit threads, and a Discord. This thesis examines discursive strategies …

Envisioning A Grassroots Framework For Community-Based Mental Health Crisis Intervention, Xandra C. Gradine

Cal Poly Humboldt theses and projects

The mental health and well-being of both individuals and communities are going to be best served by community-based services and care completely unreliant on traditional top-down models that often include inaccessible services and/or coercive methods. This is especially prevalent in the case of mental health crisis intervention; where most state-based interventions involve coercive agents who often are not given any specific training on mental health crisis response. As mental health crisis and suicide rates continue to rise in the U.S., and even the most well-respected model of crisis intervention has done little to resolve the issues of prisons serving as …

Evaluating The Impact Of Video Based Instruction And Immediate Feedback On The Performance Of Three Gross Motor Skills For Participants With Down Syndrome, Alyssa Gadberry

Cal Poly Humboldt theses and projects

The purpose of this study was to evaluate the impact of video based instruction combined with immediate visual feedback on the performance of three different gross motor skills for children with Down Syndrome (DS). The participants in this study are two children with DS. They were selected for this study based upon these qualifying factors: enrolled in a moderate/severe special day class, enrolled in a title one school, have Down syndrome and displayed deficits in gross motor abilities based upon the administration of the Total Gross Motor Development-3 (TGMD-3) assessment. The research design is a multiple baseline design where three …

“There's Always People In The Room For Whom This Is Not Merely Theory”: Emergent Pedagogies, Casey Mccullough

Cal Poly Humboldt theses and projects

Colleges and universities are generally regarded as a place for students to expand their skill sets and knowledge in preparation for specific fields of work. Many academic institutions and disciplines are also focused on recruiting and retaining students from socially marginalized communities in the name of equity, inclusion, and diversity. Despite this, some institutions in practice prioritize image, status, and wealth while deprioritizing resources, care, and support for students and their learning conditions. Often within these institutions are educators who challenge these systems in their courses, on campus, and across the country, encouraging and empowering students to directly confront those …

Techno-Economic Feasibility Of Electrifying Food Markets In Nigeria With Biogas Hybrid Mini-Grids, Demi Temitope Ogunwo

Cal Poly Humboldt theses and projects

This thesis explored the feasibility of electrifying a food market in an urban city in Nigeria with a hybrid biogas-powered mini-grid. Under the Energizing Economies Initiative of the Rural Electrification Agency of Nigeria, nine markets in the country currently receive constant access to electricity via hybrid mini-grid systems. As a majority of these systems are diesel-solar-battery systems, this thesis explored the use of biogas generators as a substitute for diesel generators in hybrid mini-grids for food markets. A fruit and vegetable market in Ketu, Lagos was used as a case study for the research. The research for this thesis was …

Determining Haplotype Specific X Chromosome Inactivation State And Related Epigenetic Features In Female X-Linked Genes, Ariah Dawn Mackie

Cal Poly Humboldt theses and projects

Females with heterozygous X-linked mutations are prone to pseudo-haploinsufficiency because random X chromosome inactivation (XCI) silences one of their two X chromosomes. A prior study explored the theory that reactivating the silenced healthy allele could be a treatment for pseudo-haploinsufficient females. The next step was to evaluate this approach in a clinically relevant stem cell model of the rare neurological disease CDKL5 Deficiency Disorder (CDD). It was necessary to validate X-inactivation state with respect to CDKL5 allele expression in one of these models. We explored CDKL5 allele expression in two populations of CDD female patient-derived induced pluripotent stem cells (iPSCs) …

Escherichia Coli And Salmonella Sp. In Domestic Cattle And Wild Roosevelt Elk: Fecal Pathogens At The Wildlife-Domestic Interface, Emily A. Buck

Cal Poly Humboldt theses and projects

Direct or indirect contact between domestic populations of animals and wildlife carries an inherent risk for transmission of pathogens that cause infectious disease. In Humboldt and Del Norte counties of northern California, ongoing conflict between ranchers and Roosevelt elk groups results from elk use of ranching pastures and pastures on private land. Fecal samples from elk in association with cattle, cattle, and from elk not in known association with cattle were assessed for the presence of bacteria Salmonella enterica and pathogenic Escherichia coli to assess whether association with cattle increases risk of infection for elk. Group identity (one of the …

Hormonal Medications And Partner Odor Preferences, Jeffrey Lee Frederick

Cal Poly Humboldt theses and projects

The ability to recognize kin through the olfactory sense has important survival and evolutionary implications when choosing mates. Failing to recognize kin when making a choice of whom to mate with can lead to an increase in detrimental genetic outcomes in offspring. Previous studies have indicated that normally ovulating heterosexual women and men prefer the body odor of those with dissimilar immune systems than those with similar immune systems. The use of hormonal contraceptives has shown a preference for similar immune system odors. The current study examines whether the use of hormonal medications predicts preference for body odor. Importantly, this …

Exploring The Knowledge Of Wildfire Smoke Mitigation And Tolerance Measures Within A High-Risk Community In San Diego County, California, Nicole C. Salas

Cal Poly Humboldt theses and projects

This study focuses on a community’s interest and knowledge on air quality mitigation measures in regard to smoke exposure from wildfires. A combination of semi-structured in person interviews and online surveys were available for those individuals that lived or worked in Ramona, California. The residents in Ramona had varying knowledge, concern levels and responses when discussing air quality mitigation measures with regards to wildfire smoke effects and impacts. Wildfire smoke itself was not a major concern of most residents within the area and many had described wildfire smoke mitigation measures as being conditional measures not applicable to the entire community …

The Effect Of Brain Breaks On Student Outcomes Of School-Aged Children In K-12 Classrooms: A Meta-Analysis, Teron H. Schaeffer

Cal Poly Humboldt theses and projects

BACKGROUND: Integrated physical activity in the classroom has been shown to affect K-12 students’ development positively. Students of all abilities benefit from multimodality learning. PURPOSE: This study investigates the relationship between classroom brain breaks and school-aged students' classroom behaviors. METHODS: The Meta-analysis search process consisted of 3 Phases: (1) Screen the titles, (2) Screen the abstracts, and (3) Retrieve the Full Text. Literature searches were conducted in eight electronic academic journal databases: SPORTDiscus, PsycINFO, PsycARTICLES, Cochrane Database, Web of Science/Web of Knowledge, ProQuest, Child Development and Adolescent Studies, and ERIC. Students (N) are enrolled in schools serving students from kindergarten …

Counter Archives: Unfolding Hidden Stories, Berlin Loa

Cal Poly Humboldt theses and projects

We select what we value as history creating collective memory that can obfuscate or devalue other threads in the story intentionally or unintentionally. Through collections of material culture, curated and described by archivists, we receive information that constructs our collective memory of self. These cultural artifacts reflect and reconstruct the past. Material artifacts in the archives depend largely on the story that is told about their provenance to provide meaning. This paper takes photographic collections in archives as examples of material culture to demonstrate how archival presentation affects the stories of collections items, and examines modalities and subverted stories in …

Methods Of Anomaly Detection: An Applied Framework And Application To Health Economics, Nathaniel Eric Islip

EWU Masters Thesis Collection

No abstract provided.