Detection And Reporting Of Child Abuse And Neglect: A Survey Amongst Pediatric Dental Care Providers In The United States, Daniel J. Lander

Theses and Dissertations

Purpose: The purpose of this study is to survey pediatric dental care providers in the United States to evaluate their knowledge in the detection and reporting of child abuse and neglect (CAN). Methods: This study has been modeled as a cross sectional- survey based research study. Email invitations were sent to pediatric dentists, orthodontists, and others who work in pediatric dental practices in the United States through email lists of the American Association of Pediatric Dentists (AAPD) and the American Association of Orthodontists (AAO). The survey completion page included sample text and the public survey link for providers to use …

How Is Biophilic Urbanism Being Used In Planning To Rejuvenate Post-Industrial Cities?, Andrea A. Kerley

Theses and Dissertations

ARE POST-INDUSTRIAL CITIES USING BIOPHILIC URBANISM TO MERGE NATURE AND THE BUILT ENVIRONMENT? A PLAN EVALUATION OF FOUR U.S. LEGACY CITIES

By Andrea (Andi) Ames Kerley, Master in Urban and Regional Planning

A thesis submitted in partial fulfillment of the requirements for the degree of Master of Urban and Regional Planning, at Virginia Commonwealth University.

Virginia Commonwealth University, 2020.

Major Director: Megan Z. Gough, Associate Professor, L. Douglas Wilder School of Government and Public Affairs,

Urban and Regional Studies and Planning

The re-imaging of U.S. post-industrial cities from desolate, impoverished, and polluted areas to unique, equitable, and environmentally aware cities …

Flourish: Exploring Healing Environments In A Residential Treatment Setting, Emily D. Kalafian

Theses and Dissertations

The following project explores the ways in which our environments promote healing and support recovery through the design of a residential center for eating disorder recovery. The center will serve 8-10 young women as they seek recovery from restrictive forms of eating disorders. The center will accommodate the necessary staff personnel as well as spaces for supporting activities and wraparound services. The project intends to create a place for healing that feels safe, warm, and considers patients’ needs for autonomy, dignity, and a sense of control amidst disorder. This is a place to create meaningful relationships and to participate in …

Wet, Flowering, Dry, Caroline A. Minchew

Theses and Dissertations

Wet, flowering, dry is a series of photographic works that explore how vernal pools are a macrocosm for holding memory and a site of omnipresent solitude and decay. This installation distills an embodied and ephemeral experience of how we are grounded in a network of invisible connections with our surroundings. This network becomes evident through biological, historical, and field research conducted at the vernal pools for over a year. Through slow observation and consideration of how multiple stories of place can weave together into a larger parable, Wet, flowering, dry reveals how the life cycle of a vernal pool is …

Traumatic Brain Injury-Induced Changes Of Immune/Inflammatory Response In The Context Of Predisposition Of Alzheimer’S Disease, Alexandra Pedin

Theses and Dissertations

Alzheimer’s Disease (AD) is a progressive neurogenerative disease that affects millions globally. At this time there are no effective treatment options as the primary cause for AD is not fully understood. In addition to old age, genetic predisposition, and certain health conditions, traumatic brain injury (TBI) has been identified as a risk factor for AD. While the pathway that links TBI to AD is still largely unknown, the neuroinflammatory response to both conditions has been connected to the NLRP3 inflammasome. Due to its role in the innate immune system and proinflammatory cytokine mediation, the NLRP3 inflammasome could be a potential …

Defiantly Childlike: Using Aesthetic Resistance To Heal, Sarah K. Reagan

Theses and Dissertations

This thesis examines an alternative processing mechanism surrounding the act of healing after traumatic experiences in life. Using a methodology of iterative patterning and tool-pathing, a collection of inflatable garments and wooden mannequins analyzes defense mechanisms learned in early childhood development. This work highlights an essential body of recent scholarship that takes cuteification seriously to restore a childlike approach to mastering fear. This paper will review the definitions of cuteness and childlike humor and then describe how visual culture has implemented these components to subvert established power.

Evaluating Long-Range Transportation Plans For Mainstreaming Of Climate Adaptation Among Virginia Mpos, Sebastian L. Shetty

Theses and Dissertations

Despite the strides made towards addressing climate change through greenhouse gas (GHG) emissions reduction strategies, it has become increasingly apparent that attempting to mitigate the crisis in such a manner alone is insufficient. This thesis joins a growing body of research on how our societies must adapt to a changing climate, contributing more evidence on common barriers to adaptation and how they might be overcome. Through an attempt to evaluate the progress made towards mainstreaming, or integrating, climate change concerns into five Virginia MPOs’ long-range transportation plans (LRTPs), this study provides support for prior hypotheses around the potential for MPOs …

Characterization Of Piezo2 Involvement In Stress-Induced Alterations To Gi Function And Nociception, Cristina Smith

Theses and Dissertations

Irritable Bowel Syndrome (IBS) is a functional gastrointestinal (GI) disorder marked by visceral hypersensitivity and changes in bowel function.Visceral sensation is initiated in the dorsal root ganglia (DRG) by primary afferent nerves that detect and transduce chemical and mechanical stimuli into electrical signals which relay to the central nervous system (CNS). The aim of this investigation was to characterize the role of Piezo2, a mechanically sensitive ion channel, located in nociceptive sensory afferents in the regulation of GI function in mice subjected to Water Avoidance Stress (WAS). Initially, body weight growth, colonic transit time, and somatic von Frey filament testing …

Connections Exposed | A Library For The People, Stephanie Wilburn

Theses and Dissertations

MOTIVATION

The U.S. economy, democracy, and the health and happiness of citizens depends on maintaining social capital, the networks of bonds between community members. Social capital creates the trust that facilitates action and cooperation for mutual benefit. Since the 1960s, there has been a decline in-person socialization and social bonds both within and between demographic groups in the US resulting in reduced social capital (Putnam, 2000).

One measure to combat declining social capital is to create third places where incidental and repeated social interactions build and reinforce bonds between community members (Oldenburg, 1997).

With the reduction of accessible and inclusive …

An Exploration Of A Researcher-Instructor Partnership In Implicit Racial Bias Awareness And Mitigation In College Stem Classrooms, Jacqueline Johnson Wilson

Theses and Dissertations

Seventy-six percent of all minority students who enter college with declared majors in science, technology, engineering, and mathematics (STEM) do not graduate with STEM degrees. Black students represent 40% of minority attrition from STEM. Implicit racial bias was indicated as a contributor to the challenges faced by Black students. The purpose of this study was to explore whether a researcher-instructor partnership brought awareness to and the potential for mitigation of implicit racial bias in course delivery and instructor interactions with Black students in STEM classes. A case study design was used over three phases to gather survey, observational, and interview …

Shared Decision Making In Adolescence: The Role Of Race And Health Status, Mona L. Quarless

Theses and Dissertations

Youth participation in Shared Decision Making (SDM) is still a novel clinical practice with unique considerations. Moreover, though SDM has been touted as an effective model for patient-centered care it has largely been underutilized and under-researched in Black and Latinx adolescent populations. The current study examined the association of health factors that may relate to Black and Latinx adolescents, their families, and HCPs engaging in SDM. Specifically, I examined within-group racial differences in relation to health conditions (i.e., pain, obesity, mental health status) and SDM during adolescence. Measures of adolescent chronic pain, BMI status (overweight/obese), mental health symptoms (depression/anxiety), SDM …

Towards New Antimalarial Drug: Depolarization Of Liposomal Membranes By Aminooxoethylcarbamothioate In The Presence Of Fe3+ Ions, Aaron Wilson

Theses and Dissertations

Despite the efforts of scientists around the world 409,000 people died of malaria in 2019 alone. According to the WHO 90% of those deaths occurred in Africa. Despite the high number of available treatments, malaria continues to plague many parts of the world. This is due in part to drug resistance developed among mosquito populations as well as limited access to medicines that do work. Furthermore, when traveling to malaria prone areas, pretreatment with a chemoprophylaxis is common practice. However, often the side effects to malaria pretreatment are severe. A new approach to the treatment of malaria is a compound …

Mindfulness Training To Enhance Emotion Regulation In A Polarizing Political Context: A Multimethod Investigation, Hadley Rahrig

Theses and Dissertations

The U.S. continues to show an upward trend in political polarization, perceived as a moral divide between liberal and conservative ideological groups. This moralization of political identity has contributed to the escalation of negative emotions (e.g., fear, anger, and hatred) directed towards political outgroup members. Although negative emotions are potent motivators of political intolerance, these emotions are nevertheless subject to regulation. Mindfulness offers a promising yet understudied emotion regulation strategy which may facilitate open receptivity towards opposing partisans. The present randomized controlled trial (RCT) examines the effects of short-term mindfulness training (MT) vs structurally equivalent Cognitive Reappraisal training (CT) on …

Sociodemographic And Injury Severity Characteristics As Predictors Of Functional Independence In Older Adults With Tbi Up To 10 Years Post Injury, Carmen M. Tyler

Theses and Dissertations

Traumatic brain injury (TBI) incidence rates have been increasing in recent years, with the greatest number of TBIs and the highest morbidity and mortality rates in individuals aged 80 and over. As average life expectancy continues to increase, the older adult population is expected to comprise nearly one-quarter of the U.S. populace by 2060. With the increased risk to a larger proportion of the U.S. population posed by TBI, the aim of the current study was to examine the roles of sociodemographic and injury severity characteristics as predictors of functional independence trajectories across 1, 2, 5, and 10 years after …

Chronic Adolescent Stress As A Predictive Factor For The Risk Of Developing Ptsd-Like Symptoms In Adulthood, Grace K. Young

Theses and Dissertations

Post-traumatic stress disorder is a stress and trauma based psychological disorder that is defined by the DSM-IV as an anxiety disorder that affects approximately 7.8% of people in the United States. PTSD is when those who suffer a traumatic event have intense and distressing feelings, emotions, and memories for a prolonged period of time after the event. A prominent feature of PTSD is the impaired ability to properly extinguish a fear response after a dangerous trigger or stressor is no longer present, also known as safety learning. Stressors are threats perceived within the environment that activate a response within the …

Shackled: To A Front-Row Seat Of My Own Horror Film, Dellil L. Mohammed

Theses and Dissertations

This document serves as internal view point, stemming from my experiences as a black muslim, first generation Ethiopian American, overall identity, and it’s disorienting implication on my interpretation of my view-self and the world. This is also informed by my struggling with the realities of type-1 diabetes and the sporadic and often inadequate support of the American health system. All of these intersecting experiences have led to me making work as an agent for advocacy, empathy and social justice. This work is also informed and dressed with the elements of horror, sci-fi, & fantasy. See and hear the voice in …

Plan Quality And Isotoxic Dose Escalation Investigation Using A 0.35t Mr-Linac System In Ablative 5-Fraction Stereotactic Magnetic Resonance-Guided Radiation Therapy (Mrgrt) For Primary Pancreatic Cancer, Robert Eric Hawranko

Theses and Dissertations

This study investigates plan quality generated by an MR-Linac (MRL) treatment planning system (TPS) for 5-fraction stereotactic body radiation therapy (SBRT) of primary pancreatic cancer (PCa). In addition, an isotoxic dose escalation was investigated with the MRL TPS based on the stereotactic MR-guided adaptive radiation therapy (SMART) trial constraints. A clinical workflow was developed for adaptive and non-adaptive treatments with the MRL, on which a time-driven activity-based costing (TDABC) analysis was performed to quantify clinical efficacy. Fifteen Pca patients previously treated with a conventional Linac were retrospectively re-planned for this study. Three plans were generated for each patient: using the …

Human Papillomavirus 16 E2 Regulates Host Cell Pathways Important For Cancer Progression And Treatment Sensitivity Which May Contribute To Cancer Outcomes, Christian Fontan

Theses and Dissertations

Human papillomaviruses (HPVs) are causative agents in around 5% of all cancers, including cervical and oropharyngeal. A feature of HPV cancers is their better clinical outcome compared with non-HPV anatomical counterparts. In turn, the presence of E2 predicts a better clinical outcome in HPV-positive cancers; the reason(s) for the better outcome of E2-positive patients is not fully understood.

Previously, we demonstrated that HPV16 E2 regulates host gene transcription that is relevant to the HPV16 lifecycle in N/Tert-1 cells. One of the genes repressed by E2 and the entire HPV16 genome in N/Tert-1 cells is TWIST1. In these studies, we demonstrate …

Therapeutic Injectable Iron-Chelating Hydrogels, Debbie Campbell-Rance

Theses and Dissertations

ABSTRACT

Therapeutic Injectable Iron-Chelating Hydrogels for Improved Central Nervous System Regeneration

By

Debbie S. Campbell-Rance

A dissertation submitted in partial fulfillment of the requirements of the degree of Doctor of Philosophy at Virginia Commonwealth University 2021.

Director: Xuejun Wen, M.D., Ph.D., AIMBE Fellow, Alice T. and William H. Goodwin Jr. Endowed Chair Professor in Regenerative Medicine, Institute for Engineering and Medicine, Department of Chemical and Life Science Engineering

Severe traumatic brain and spinal cord injuries are major global public health and socioeconomic problems in terms of mortality and morbidity. Currently there are two main lines of treatment under development for …

Multi-Modality Automatic Lung Tumor Segmentation Method Using Deep Learning And Radiomics, Siqiu Wang

Theses and Dissertations

Delineation of the tumor volume is the initial and fundamental step in the radiotherapy planning process. The current clinical practice of manual delineation is time-consuming and suffers from observer variability. This work seeks to develop an effective automatic framework to produce clinically usable lung tumor segmentations. First, to facilitate the development and validation of our methodology, an expansive database of planning CTs, diagnostic PETs, and manual tumor segmentations was curated, and an image registration and preprocessing pipeline was established. Then a deep learning neural network was constructed and optimized to utilize dual-modality PET and CT images for lung tumor segmentation. …

Modeling Of Patient-Specific Periaortic Mechanics And Pulmonary Artery Hemodynamics Based On Phase-Contrast Magnetic Resonance Imaging Sequences., Johane H. Bracamonte

Theses and Dissertations

Inverse modeling in cardiovascular medicine is a collection of methodologies that can provide non-invasive patient-specific estimations of clinical risk factors using medical imaging as inputs. Its incorporation into clinical practice has the potential to improve diagnosis and treatment planning with low associated risks and costs.

Herein, three different phase contrast magnetic resonance imaging (MRI) modalities were implemented as input data, displacement encoding with stimulated echoes (DENSE MRI) applied, and time-resolved velocity encoding phase-contrast MRI, in 1D and 3D, applied to pulmonary artery (PA) hemodynamics.

A model to account for the effect of periaortic interactions due to static and dynamic structures …

Using Molecularly Imprinted Polymers For The Selective Extraction Of Analytes, Haley A. Mulder

Theses and Dissertations

Sample preparation is a critical steps in bioanalysis. Traditional methods such as solid-phase extraction and liquid-liquid extraction are laborious and ultimately incapable of properly separating target analytes from matrix and interferents. The co-extraction of these components interferes with the analytical instrument’s ability to properly detect and quantitate analytes. Molecularly imprinted polymers (MIPs) are synthetic polymers that have been “imprinted” with a template analyte in a co-polymer system. MIPs are capable of selectively extracting analytes from complex biological matrices and can be employed in off-line, benchtop extractions or for on/in-line instrument extractions. MIPs offer faster and more selective sample preparation, leading …

Modulating Ketamine’S Locomotor Activating And Reinforcing Effects Through Drug Combinations, Tegshjargal Baasansukh

Theses and Dissertations

Major Depressive Disorder (MDD) affects approximately 280 million people worldwide. The standard of care for pharmacological treatment of MDD has been monoaminergic antidepressants (MAA). However, MAAs have serious clinical limitations including a relatively slow onset of action and up to 40% of patients failing to respond and being diagnosed as “treatment resistant”. Ketamine, an N-methyl-D-aspartate antagonist, was originally approved for use as an injectable anesthetic. In addition, ketamine has been shown to rapidly improve depressive symptoms in patients with treatment resistant depression. In 2019, (S)-ketamine was approved as a nasal spray (Spravato®) for patients with MDD and treatment-resistant depression in …

A Case Study Exploring How The Zero Barriers In Stem Education Professional Development Program Affects Attitudes And Confidence Toward Teaching Stem Content To Students With Disabilities, Alison Dossick

Theses and Dissertations

This study was designed to assess how the Zero Barriers in STEM Education professional development (PD) course affected teacher attitudes and confidence in teaching science, technology, engineering, and mathematics (STEM) content to students with disabilities. A convergent mixed-methods case study analysis was used. The research questions were devised by examining answers on a pre-survey and post-survey. Documentation included a full analysis of two pre- and post-surveys, teacher implementation logs, team action plans, program evaluations, and semi-structured interviews. Barriers included time to plan and implement the outlined strategies and administrative and colleague support. This research uncovered some of the difficulties of …

Connected: Exploring Automation To Activate Aging In Place Success, Hallie W. Gillespie

Theses and Dissertations

MOTIVATION: There’s no place like home. Technological advances are now allowing us to live and work from anywhere. Spatial divides are disappearing through remote connections, creating a dispersion of the nuclear family, traditionally the prevailing caregivers for seniors. Older adults are projected to outnumber children under eighteen by 2034, a first in U.S. history (Census Bureau, 2019). This is not specific to America; “globally the population is aging. Since 1980, the number of people aged over 60 has more than doubled in size and is projected to do so again by 2050 to 2.1 billion” (United Nations, 2017).

ISSUE: There …

Academic Health Science Centers And Health Disparities: A Qualitative Review Of The Intervening Role Of The Electronic Health Record And Social Determinants Of Health, Wies Rafi

Theses and Dissertations

Literature on the magnitude of negative health outcomes from health disparities is voluminous. Defined as the health effects of racism, environmental injustice, forms of discrimination, biases in science, and sociological or socioeconomic predictors across populations, health disparities are part of an ongoing and complicated national problem that health equity programs are specifically designed to address. Academic Health Science Centers (AHC) institutions are a complex and unique educational-healthcare ecosystem that often serves as a safety net for patients in vulnerable and lower-income communities. These institutions are often viewed as one of the most uniquely positioned entities in the U.S. with an …

Supported Employment Services And Employment Outcomes For Low-Income Youth With Intellectual And Developmental Disabilities: A Case Control Study, Hannah Seward Phd

Theses and Dissertations

Transition-age youth, ages 14-24 years old, with intellectual and developmental disabilities (IDD) face unique barriers to entering the labor force when exiting high school. These barriers can be even more severe if the youth is from a low-income background. Supported employment (SE) services may help this population overcome these barriers and be employed in competitive integrated employment (CIE) settings. SE provides an employment specialist to guide them through obtaining and retaining a job (McDonough & Whittenburg, 2020; Wehman et al., 2007). However, limited research has been done on the SE experiences and outcomes of transition-age youth with IDD (Wehman et …

Examining The Behavioral And Phyisiolgical Effects Of D-Methamphetamine Administered Via E-Cigarette Aerosolization, Srikethan Mahavadi

Theses and Dissertations

Abstract

EXAMINING THE BEHAVIORAL AND PHYISIOLGICAL EFFECTS OF D-METHAMPHETAMINE ADMINISTERED VIA E-CIGARETTE AEROSOLIZATION

By Srikethan Mahavadi, B.S.

A thesis submitted in partial fulfillment of the requirements for the degree of Master of Science at Virginia Commonwealth University

Virginia Commonwealth University, 2021

Principal Investigator: Dr. Keith Shelton, PhD., Department of Pharmacology & Toxicology

E-cigarettes have become increasing popular worldwide. They are primarily used as a means to deliver nicotine to users, but these devices may also be used to administer a wide range of other substances including psychomotor stimulants such as d-methamphetamine. Methamphetamine has been widely abused throughout the United States …

Alcohol And Other Addictive Behaviors Among Bariatric Surgery Patients, Rachel M. Arnold

Theses and Dissertations

Research has repeatedly highlighted a high rate of comorbidity of addictive behaviors in both clinical and non-clinical samples. While polydrug use has received significant attention in recent years, less is known about rates of comorbidity with behavioral addictions such as eating, work, exercise, or sex. Individuals with a history of bariatric surgery may provide a unique opportunity to examine the potential co-occurrence of addictive behaviors. High rates of food addiction symptoms and changes in alcohol use patterns post-surgically have highlighted a potential gap in our understanding of bariatric patients and their needs post-surgically. Using a composite measure of addictive behaviors, …

Characterizing The Patterns, Predictors, And Processes Involved In Recovery From Substance Use Disorders, Rebecca L. Smith

Theses and Dissertations

Alcohol and drug use disorders are associated with significant cost to individuals, families, and society.Approximately 40-75% of affected individuals remit from alcohol use disorders (AUD). Although the development of AUD is well studied, recovery from AUD and factors that contribute to recovery are not as well characterized. With the definition of recovery evolving towards a process rather than an outcome, there is a need to better understand psychosocial functioning and quality of life among individuals at different points in their recovery journeys. Concurrently, additional research is needed to understand the interplay between sources of recovery capital, individual differences in risk …