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2022

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Cardiorespiratory Fitness Is A Risk Factor For Lower-Limb And Back Injury In Law Enforcement Officers Commencing Their Basic Training: A Prospective Cohort Study, Myles C. Murphy, Nicole Merrick, Andrea B. Mosler, Garth Allen, Paola Chivers, Nicolas H. Hart Jan 2022

Cardiorespiratory Fitness Is A Risk Factor For Lower-Limb And Back Injury In Law Enforcement Officers Commencing Their Basic Training: A Prospective Cohort Study, Myles C. Murphy, Nicole Merrick, Andrea B. Mosler, Garth Allen, Paola Chivers, Nicolas H. Hart

Physiotherapy Papers and Journal Articles

We aimed to report the epidemiology of lower-limb and lumbosacral injuries in Police Force recruits. We performed a cohort study of Police Force recruits undergoing a six-month training program with prospective injury data collected between 2018 and 2021. Cardiorespiratory fitness was quantified by the beep-test and police-specific-functional-capacity was quantified using a specifically designed physical performance evaluation (PPE) tool. Injury frequency and prevalence were reported. Fifteen percent (n = 180) of study Police Force recruits (n = 1,181) sustained a lower-limb or lumbosacral injury. The six-month training program significantly improved cardiorespiratory fitness (p < 0.001) and functional capacity (p < 0.001). Increased cardiorespiratory fitness at baseline decreased injury risk (OR = 0.8, 95%CI: 0.66–0.97, p = 0.019). Injury rates decreased over time and females were injured significantly earlier than males (HR = 0.70, 95%CI: 0.52 to 0.95, p = 0.021). Interventions that can pre-condition Police Force recruits prior to the commencement of their basic physical training may reduce the number of lower-limb and lumbosacral injuries.


Managing Agricultural Nitrogen Losses In Crop Production And Mitigation Of Climate Change Effects, Winnie Ntinyari, Mekonnen Giweta, James Mutegi, Cargele Masso, Joseph P. Gweyi-Onyango Jan 2022

Managing Agricultural Nitrogen Losses In Crop Production And Mitigation Of Climate Change Effects, Winnie Ntinyari, Mekonnen Giweta, James Mutegi, Cargele Masso, Joseph P. Gweyi-Onyango

All Peer-Reviewed Publications

Nitrogen (N) losses from cropping systems negatively affect soil quality/fertility, crop yield, and the environment through its contribution to climate change and water pollution. İt possesses oil-water-atmospheric system challenges to both the too much and the too little N application countries. Soil and climatic factors are the critical drivers of N loss from agricultural systems as they influence major processes like nitrification and denitrification. Other N loss pathways include leaching, runoff, and volatilization. Nitrous oxide (N2O) and ammonia (NH3) gases are the two pollutants resulting from N fertilizers in crop production and represent N loss’ significant pathway. Nitrous oxide is …


Microsporidia: A Promising Vector Control Tool For Residual Malaria Transmission, Tullu Bukhari, Roland Pevsner, Jeremy Keith Herren Jan 2022

Microsporidia: A Promising Vector Control Tool For Residual Malaria Transmission, Tullu Bukhari, Roland Pevsner, Jeremy Keith Herren

All Peer-Reviewed Publications

Long-lasting insecticidal nets (LLINs) and indoor residual spraying (IRS) have resulted in a major decrease in malaria transmission. However, it has become apparent that malaria can be effectively transmitted despite high coverage of LLINs/IRS. Residual transmission can occur due to Plasmodium-carrying Anopheles mosquitoes that are insecticide resistant and have feeding and resting behavior that reduces their chance of encountering the currently deployed indoor malaria control tools. Residual malaria transmission is likely to be the most significant hurdle to achieving the goal of malaria eradication and research and development towards new tools and strategies that can control residual malaria transmission is …


The Association Of The Development Of The Internal Reproductive Organs Of Male Desert Locusts, Schistocerca Gregaria (Orthoptera: Acrididae), With Age, Phase And The Effect Of Exposure To Pheromones, Satoshi Hiroyoshi, Takayuki Mitsunaga, Gadi V.P. Reddy Jan 2022

The Association Of The Development Of The Internal Reproductive Organs Of Male Desert Locusts, Schistocerca Gregaria (Orthoptera: Acrididae), With Age, Phase And The Effect Of Exposure To Pheromones, Satoshi Hiroyoshi, Takayuki Mitsunaga, Gadi V.P. Reddy

All Peer-Reviewed Publications

The regulation of the development of the male reproductive organs in insects is still an open question. Although the desert locust, Schistocerca gregaria, has been extensively examined, there is little information on the effects of phase and pheromones on the development of the male reproductive organs. This study clarifi ed the association of these two factors with reproductive development (length or width of each organ) of the testis, testicular follicles, accessory glands, and seminal vesicles in this locust. The width of the follicles and width and length of the accessory gland mass are signifi cantly associated with phase (solitary or …


Performance Of Black Soldier Fly Frass Fertiliser On Maize (Zea Mays L.) Growth, Yield, Nutritional Quality, And Economic Returns, C. M. Tanga, D. Beesigamukama, M. Kassie, P. J. Egonyu, Changeh J. Ghemoh, Kiatoko Nkoba, S. Subramanian, A. O. Anyega, S. Ekesi Jan 2022

Performance Of Black Soldier Fly Frass Fertiliser On Maize (Zea Mays L.) Growth, Yield, Nutritional Quality, And Economic Returns, C. M. Tanga, D. Beesigamukama, M. Kassie, P. J. Egonyu, Changeh J. Ghemoh, Kiatoko Nkoba, S. Subramanian, A. O. Anyega, S. Ekesi

All Peer-Reviewed Publications

Although the black soldier fly frass fertiliser (BSFFF) is globally recognised as a promising and potential high-quality organic fertiliser, there is inadequate information on its impact on the growth performance and nutritional status of maize. Furthermore, no information exist on their combination with mineral fertiliser (NPK) as well as economic impact on maize production. This study evaluated the comparative impact of BSFFF, NPK and commercial organic fertiliser (Evergrow®) on growth, nitrogen use efficiency, yield, nutritional quality, and profitability of maize under greenhouse conditions. The treatments included: (1) sole application of BSFFF, conventional compost of brewers’ spent grain (BSG), Evergrow, and …


Inter-Population Variation And Phenotypic Plasticity In Kairomone Use By A Poly-Specialist Spider-Eating Predator, Ana M. Cerveira, Robert R. Jackson Jan 2022

Inter-Population Variation And Phenotypic Plasticity In Kairomone Use By A Poly-Specialist Spider-Eating Predator, Ana M. Cerveira, Robert R. Jackson

All Peer-Reviewed Publications

Previous research on Cyrba algerina (Araneae, Salticidae) has shown this jumping spider expresses predatory specialisation with respect to spiders as prey as well as inter-population variation in responsiveness to prey-spider odour. However, this earlier research pertained to a single prey species (Oecobius machadoi) and only field-collected C. algerina individuals were tested. Here we extend the previous research by using laboratory-reared, as well as field-collected, individuals of C. algerina and also by using another prey-spider species, Zelotes thorelli, as well as O. machadoi. Two localities in Portugal are considered, Sintra where C. algerina and both prey species are abundant and Tavira …


Exploring The Feasibility Of Virtually Delivered Auricular Point Acupressure In Self-Managing Chronic Pain: Qualitative Study, Jennifer Kawi, Chao Hsing Yeh, Nada Lukkahatai, Robin L Hardwicke, Thomas Murphy, Paul J Christo Jan 2022

Exploring The Feasibility Of Virtually Delivered Auricular Point Acupressure In Self-Managing Chronic Pain: Qualitative Study, Jennifer Kawi, Chao Hsing Yeh, Nada Lukkahatai, Robin L Hardwicke, Thomas Murphy, Paul J Christo

Faculty, Staff and Student Publications

BACKGROUND: Chronic pain remains highly prevalent. Current pharmacological and non-pharmacological strategies have not adequately managed chronic pain which has contributed to disability and high healthcare costs. With existing challenges in providing adequate pain care and access, we tested vAPA, a virtually delivered, self-management intervention using Auricular Point Acupressure (APA) by mobile app and virtual consultations (telehealth). Our key purpose was to evaluate the feasibility of the vAPA in self-managing chronic pain in preparation for a future randomized controlled trial.

METHODS: We conducted a descriptive, qualitative study evaluating our 4-week vAPA intervention among 18 participants. We used directed qualitative content analysis. …


The Current State Of Fellowship Leadership In Dermatology: Trends In Workforce Demographics And Scholarly Productivity, Steven Idell, David D Mcpherson, Jessica Martin, Andrew Dentino, Luis Ostrosky-Zeichner, Julia V Philley, Paul Mcgaha, Megan Devine, Jacqueline Bronicki, Daniel D Karp Jan 2022

The Current State Of Fellowship Leadership In Dermatology: Trends In Workforce Demographics And Scholarly Productivity, Steven Idell, David D Mcpherson, Jessica Martin, Andrew Dentino, Luis Ostrosky-Zeichner, Julia V Philley, Paul Mcgaha, Megan Devine, Jacqueline Bronicki, Daniel D Karp

Faculty, Staff and Student Publications

In 2018, The University of Texas Health Science Center-Tyler and University of Texas Rio Grande Valley were invited to develop clinical research units for an existing Clinical and Translational Science Award (CTSA) consortium with the objective to equip medically underserved, economically disadvantaged communities and subsequently to deploy COVID-19 clinical trials in response to a public health emergency.


Comparison Of Two Diet And Exercise Approaches On Weight Loss And Health Outcomes In Obese Women, Brittanie Lockard, Michelle Mardock, Jonathan M. Oliver, Mike Byrd, Sunday Simbo, Andrew R. Jagim, Julie Kresta, Claire C. Baetge, Yanghoon Peter Jung, Majid S. Koozehchian, Deepesh Khanna, Chris Rasmussen, Richard B. Kreider Jan 2022

Comparison Of Two Diet And Exercise Approaches On Weight Loss And Health Outcomes In Obese Women, Brittanie Lockard, Michelle Mardock, Jonathan M. Oliver, Mike Byrd, Sunday Simbo, Andrew R. Jagim, Julie Kresta, Claire C. Baetge, Yanghoon Peter Jung, Majid S. Koozehchian, Deepesh Khanna, Chris Rasmussen, Richard B. Kreider

Research, Publications & Creative Work

Aim: To compare the efficacy of two popular weight loss approaches on weight loss, body composition, and markers of health in sedentary obese women. Methods: In total, 51 sedentary women (age 34.5 ± 7.7 yrs.; weight 90.0 ± 14.5 kg; BMI 34.0 ± 5.1 kg/m2 ; 46.5 ± 7.0% fat) were matched and randomized to participate in the Weight Watchers® Momentum™ (WW) or Curves® (CV) Fitness and Weight Management program for 16 weeks. Participants in the WW group (n = 27) were provided a point-based diet program, received weekly progress checks and counseling, and were encouraged to exercise. Participants in …


Invited Perspective - Engaging Aspirations To Nurture Communities, Kentaro Toyama Jan 2022

Invited Perspective - Engaging Aspirations To Nurture Communities, Kentaro Toyama

Subsistence Marketplaces

For subsistence communities, the question is whether aspirations can be applied to motivate behavior that is, on the one hand consistent with people’s aspirations, but which might otherwise be difficult to elicit. Could poorer households be encouraged to save, to spend more on their children’s education, or to act against unhealthy social norms? A couple of examples suggest this is not only possible, but highly successful in contexts where other appeals fail.


Engineered Cord Blood Megakaryocytes Evade Killing By Allogeneic T-Cells For Refractory Thrombocytopenia, Bijender Kumar, Vahid Afshar-Kharghan, Mayela Mendt, Robert Sackstein, Mark R Tanner, Uday Popat, Jeremy Ramdial, May Daher, Juan Jimenez, Rafet Basar, Luciana Melo Garcia, Mayra Shanley, Mecit Kaplan, Xinhai Wan, Vandana Nandivada, Francia Reyes Silva, Vernikka Woods, April Gilbert, Ricardo Gonzalez-Delgado, Sunil Acharya, Paul Lin, Hind Rafei, Pinaki Prosad Banerjee, Elizabeth J Shpall Jan 2022

Engineered Cord Blood Megakaryocytes Evade Killing By Allogeneic T-Cells For Refractory Thrombocytopenia, Bijender Kumar, Vahid Afshar-Kharghan, Mayela Mendt, Robert Sackstein, Mark R Tanner, Uday Popat, Jeremy Ramdial, May Daher, Juan Jimenez, Rafet Basar, Luciana Melo Garcia, Mayra Shanley, Mecit Kaplan, Xinhai Wan, Vandana Nandivada, Francia Reyes Silva, Vernikka Woods, April Gilbert, Ricardo Gonzalez-Delgado, Sunil Acharya, Paul Lin, Hind Rafei, Pinaki Prosad Banerjee, Elizabeth J Shpall

Faculty, Staff and Student Publications

The current global platelet supply is often insufficient to meet all the transfusion needs of patients, in particular for those with alloimmune thrombocytopenia. To address this issue, we have developed a strategy employing a combination of approaches to achieve more efficient production of functional megakaryocytes (MKs) and platelets collected from cord blood (CB)-derived CD34+ hematopoietic cells. This strategy is based on ex-vivo expansion and differentiation of MKs in the presence of bone marrow niche-mimicking mesenchymal stem cells (MSCs), together with two other key components: (1) To enhance MK polyploidization, we used the potent pharmacological Rho-associated coiled-coil kinase (ROCK) inhibitor, KD045, …


Analyse Du Travail Des Premiers Répondants En Gestion De Crise Pandémique : Maximiser La Performance Et La Résilience, Sébastien Tremblay, Marie-Eve Drouin, Isabelle Turcotte, Fanny Audet Paradis, Gabrielle Côté, Jean-Michel Lavertu Jan 2022

Analyse Du Travail Des Premiers Répondants En Gestion De Crise Pandémique : Maximiser La Performance Et La Résilience, Sébastien Tremblay, Marie-Eve Drouin, Isabelle Turcotte, Fanny Audet Paradis, Gabrielle Côté, Jean-Michel Lavertu

États de la question, rapports d’expertise et revues de littérature

En ces temps de crise pandémique, les intervenants de première ligne se trouvent en situation de vulnérabilité accrue, alors que leurs interventions se diversifient et se complexifient. L’arrivée soudaine de la pandémie de COVID-19 a ajouté une certaine incertitude exacerbée par les fréquentes mises à jour des lignes directrices, des procédures et des protocoles dans un contexte d’intervention déjà critique où les temps de décision et de réaction sont limités. Se retrouvant au front de cette crise sanitaire, ces travailleurs sont donc plus susceptibles d’en ressentir les effets.

Ce projet de recherche a permis d’analyser le travail de ces intervenants, …


Coping Strategies And Life Satisfaction Among Romanian Emerging Adults During The Covid-19 Pandemic, Delia Ștefenel, Jose-Michael Gonzalez, Silviu Rogobete, Raluca Sassu Jan 2022

Coping Strategies And Life Satisfaction Among Romanian Emerging Adults During The Covid-19 Pandemic, Delia Ștefenel, Jose-Michael Gonzalez, Silviu Rogobete, Raluca Sassu

Psychology Faculty Publications

The aim of the present study was to understand coping mechanisms among Romanian youth in their response to institutional COVID-19 pandemic restrictions. Data were collected from emerging adults (N = 214), aged 18–29, enrolled in various fields of study throughout a public university in Romania. Adopted versions of the Coping Orientation for Problem Experiences Scale (Brief-COPE, Carver, 1997) and Satisfaction with Life Scales (SLWS, Diener et al., 1985) were administered to explore the impact of the specific social distancing and isolation enforced pandemic restrictions. Findings elucidate the response styles, impact of coping skills, and strategies employed by students toward their …


Aneuploidy And Sex Concordance Rate Between Cell-Free Dna Analysis From Spent Culture Media Of Preimplantation Embryo And Dna From Whole Embryo With Respect To Different Morphological Grading, Hiroki Sonehara, Ryoya Matsumoto, Naoki Nakayama, Masato Kobanawa, Koki Numata, Akiko Kawasaki, Makio Shozu Jan 2022

Aneuploidy And Sex Concordance Rate Between Cell-Free Dna Analysis From Spent Culture Media Of Preimplantation Embryo And Dna From Whole Embryo With Respect To Different Morphological Grading, Hiroki Sonehara, Ryoya Matsumoto, Naoki Nakayama, Masato Kobanawa, Koki Numata, Akiko Kawasaki, Makio Shozu

Faculty, Staff and Student Publications

PURPOSE: The aneuploidy and sex concordance between cell-free DNA in spent culture media (SCM) and DNA from whole embryo with respect to different morphological grading were examined to evaluate the feasibility of non-invasive preimplantation genetic testing for aneuploidy (niPGT-A).

METHODS: A total of 46 pairs of embryos and corresponding SCM were divided into two groups based on the morphological grade. DNA was extracted from 22 and 24 pairs of low- and high-grade embryos, respectively, and respective SCM followed by chromosomal analysis using next-generation sequencing. Aneuploidy study and sex determination were conducted for both groups, and concordance rates were calculated.

RESULTS: …


Invasive Haemophilus Influenza Type B In An Infant During The Covid-19 Pandemic: The Return Of Diseases We Hoped Never To See Again…, Christy Tabarani, Stephen A Fletcher, Gloria P Heresi, Susan H Wootton Jan 2022

Invasive Haemophilus Influenza Type B In An Infant During The Covid-19 Pandemic: The Return Of Diseases We Hoped Never To See Again…, Christy Tabarani, Stephen A Fletcher, Gloria P Heresi, Susan H Wootton

Faculty, Staff and Student Publications

No abstract provided.


Regenerative Medicine Technologies Applied To Transplant Medicine An Update, Astgik Petrosyan, Filippo Montali, Andrea Peloso, Antonio Citro, Lori N Byers, Catherine La Pointe, Mara Suleiman, Alice Marchetti, Eoin P Mcneill, Allison L Speer, Wai Hoe Ng, Xi Ren, Benedetta Bussolati, Laura Perin, Paolo Di Nardo, Vincenzo Cardinale, Jerome Duisit, Alexandra Rose Monetti, John Richard Savino, Amish Asthana, Giuseppe Orlando Jan 2022

Regenerative Medicine Technologies Applied To Transplant Medicine An Update, Astgik Petrosyan, Filippo Montali, Andrea Peloso, Antonio Citro, Lori N Byers, Catherine La Pointe, Mara Suleiman, Alice Marchetti, Eoin P Mcneill, Allison L Speer, Wai Hoe Ng, Xi Ren, Benedetta Bussolati, Laura Perin, Paolo Di Nardo, Vincenzo Cardinale, Jerome Duisit, Alexandra Rose Monetti, John Richard Savino, Amish Asthana, Giuseppe Orlando

Faculty, Staff and Student Publications

Regenerative medicine (RM) is changing how we think and practice transplant medicine. In regenerative medicine, the aim is to develop and employ methods to regenerate, restore or replace damaged/diseased tissues or organs. Regenerative medicine investigates using tools such as novel technologies or techniques, extracellular vesicles, cell-based therapies, and tissue-engineered constructs to design effective patient-specific treatments. This review illustrates current advancements in regenerative medicine that may pertain to transplant medicine. We highlight progress made and various tools designed and employed specifically for each tissue or organ, such as the kidney, heart, liver, lung, vasculature, gastrointestinal tract, and pancreas. By combing both …


Case Report: Novel Pathogenic Variant In Nfix In Two Sisters With Malan Syndrome Due To Germline Mosaicism, Elizabeth Langley, Laura S Farach, Kate Mowrey Jan 2022

Case Report: Novel Pathogenic Variant In Nfix In Two Sisters With Malan Syndrome Due To Germline Mosaicism, Elizabeth Langley, Laura S Farach, Kate Mowrey

Faculty, Staff and Student Publications

Malan syndrome is an autosomal dominant disorder caused by pathogenic variants in NFIX with less than 100 cases reported thus far. NFIX is important for stem cell proliferation, quiescence, and differentiation during development and its protein plays a role in replication, signal transduction, and transcription. As a result of pathogenic variants, symptoms of Malan syndrome include overgrowth, intellectual disability, speech delay, and dysmorphic features. Currently, the recurrence risk for this disorder is indicated at less than 1%, standard for de novo autosomal dominant disorders. Herein, we report an additional set of sisters with the same novel pathogenic variant in NFIX …


Impact Of Covid-19 On Nationwide Pediatric Otolaryngology Practice: Adenotonsillectomies (Ta) And Tonsil-Related Diagnoses Trends, David Z Allen, Sai Challapalli, Kyung Hyun Lee, Cynthia S Bell, Soham Roy, Sarah Bowe, Karthik Balakrishnan, C W David Chang, Zhen Huang Jan 2022

Impact Of Covid-19 On Nationwide Pediatric Otolaryngology Practice: Adenotonsillectomies (Ta) And Tonsil-Related Diagnoses Trends, David Z Allen, Sai Challapalli, Kyung Hyun Lee, Cynthia S Bell, Soham Roy, Sarah Bowe, Karthik Balakrishnan, C W David Chang, Zhen Huang

Faculty, Staff and Student Publications

Objectives/hypothesis: To determine the effects of the COVID-19 pandemic on Adenotonsillectomies (TA), Tonsil Related Cases (TC), and Peritonsillar Abscess (PTA) Trends.

Study design: Retrospective Cohort Study.

Methods: This is a retrospective cohort study using the Pediatric Health Information System® (PHIS) database, which consists of 51 children's hospitals. Regions were defined according to PHIS rules with at least five children's hospitals per region. We compared monthly total TA, TC, TC as a proportion of all hospital visits, and PTA from all encounters at each hospital from January 1, 2019, through December 31, 2021.

Results: Compared to 2019, April 2020 saw mean …


The Psychological Impact Of The Covid-19 Outbreak On Pregnancy And Mother-Infant Prenatal Bonding, Muhammad O Awiwi, Khaled M Elsayes, Yehia I Mohamed, Lina Altameemi, Migena Gjoni, Omayr Muhammad Irshad, Ahmed Sayed Ahmed, Ahmad O Kaseb, Usama Salem Jan 2022

The Psychological Impact Of The Covid-19 Outbreak On Pregnancy And Mother-Infant Prenatal Bonding, Muhammad O Awiwi, Khaled M Elsayes, Yehia I Mohamed, Lina Altameemi, Migena Gjoni, Omayr Muhammad Irshad, Ahmed Sayed Ahmed, Ahmad O Kaseb, Usama Salem

Faculty, Staff and Student Publications

PURPOSE: To identify prognostic clinical and radiologic features in patients with unresectable hepatocellular carcinoma (HCC) treated with atezolizumab plus bevacizumab.

PATIENTS AND METHODS: Clinical and imaging records of patients with unresectable HCC were retrospectively reviewed, and baseline features were recorded. Patients' records and imaging studies were used to determine the patients' overall survival (OS) and progression-free survival (PFS). Univariate and multivariate analyses were performed to determine prognostic features. Subanalyses of treatment-naïve patients (who never received local or systemic therapy) and previously treated patients were also performed.

RESULTS: Fifty-five patients were included in the final analysis, 23 (41.8%) of whom were …


Impairment Of Autophagy After Spinal Cord Injury Potentiates Neuroinflammation And Motor Function Deficit In Mice, Yun Li, Zhuofan Lei, Rodney M Ritzel, Junyun He, Hui Li, Harry M C Choi, Marta M Lipinski, Junfang Wu Jan 2022

Impairment Of Autophagy After Spinal Cord Injury Potentiates Neuroinflammation And Motor Function Deficit In Mice, Yun Li, Zhuofan Lei, Rodney M Ritzel, Junyun He, Hui Li, Harry M C Choi, Marta M Lipinski, Junfang Wu

Faculty, Staff and Student Publications

Autophagy is a catabolic process that degrades cytoplasmic constituents and organelles in the lysosome, thus serving an important role in cellular homeostasis and protection against insults. We previously reported that defects in autophagy contribute to neuronal cell damage in traumatic spinal cord injury (SCI). Recent data from other inflammatory models implicate autophagy in regulation of immune and inflammatory responses, with low levels of autophagic flux associated with pro-inflammatory phenotypes. In the present study, we examined the effects of genetically or pharmacologically manipulating autophagy on posttraumatic neuroinflammation and motor function after SCI in mice.

Methods: Young adult male C57BL/6, CX3CR1-GFP, autophagy …


A Haplotype Resolved Chromosomal Level Avocado Genome Allows Analysis Of Novel Avocado Genes, Onkar Nath, Stephen J Fletcher, Alice Hayward, Lindsay M Shaw, Ardashir Kharabian Masouleh, Agnelo Furtado, Robert J Henry, Neena Mitter Jan 2022

A Haplotype Resolved Chromosomal Level Avocado Genome Allows Analysis Of Novel Avocado Genes, Onkar Nath, Stephen J Fletcher, Alice Hayward, Lindsay M Shaw, Ardashir Kharabian Masouleh, Agnelo Furtado, Robert J Henry, Neena Mitter

Faculty, Staff and Student Publications

Avocado (Persea americana) is a member of the magnoliids, an early branching lineage of angiosperms that has high value globally with the fruit being highly nutritious. Here, we report a chromosome-level genome assembly for the commercial avocado cultivar Hass, which represents 80% of the world’s avocado consumption. The DNA contigs produced from Pacific Biosciences HiFi reads were further assembled using a previously published version of the genome supported by a genetic map. The total assembly was 913 Mb with a contig N50 of 84 Mb. Contigs assigned to the 12 chromosomes represented 874 Mb and covered 98.8% of …


Single-Cell And Single-Nuclei Rna Sequencing As Powerful Tools To Decipher Cellular Heterogeneity And Dysregulation In Neurodegenerative Diseases, Raquel Cuevas-Diaz Duran, Juan Carlos González-Orozco, Iván Velasco, Jia Qian Wu Jan 2022

Single-Cell And Single-Nuclei Rna Sequencing As Powerful Tools To Decipher Cellular Heterogeneity And Dysregulation In Neurodegenerative Diseases, Raquel Cuevas-Diaz Duran, Juan Carlos González-Orozco, Iván Velasco, Jia Qian Wu

Faculty, Staff and Student Publications

Neurodegenerative diseases affect millions of people worldwide and there are currently no cures. Two types of common neurodegenerative diseases are Alzheimer's (AD) and Parkinson's disease (PD). Single-cell and single-nuclei RNA sequencing (scRNA-seq and snRNA-seq) have become powerful tools to elucidate the inherent complexity and dynamics of the central nervous system at cellular resolution. This technology has allowed the identification of cell types and states, providing new insights into cellular susceptibilities and molecular mechanisms underlying neurodegenerative conditions. Exciting research using high throughput scRNA-seq and snRNA-seq technologies to study AD and PD is emerging. Herein we review the recent progress in understanding …


Mechanisms And Treatment Of Pain-Depressed Behavior In Male And Female Mice, Clare M. Diester Jan 2022

Mechanisms And Treatment Of Pain-Depressed Behavior In Male And Female Mice, Clare M. Diester

Theses and Dissertations

One of the largest discrepancies between preclinical and clinical assessment of pain and analgesia is the type of behavioral endpoint used. Although most preclinical research has historically focused on drug effectiveness to block reflexive withdrawal behaviors stimulated by a noxious stimulus, increasing evidence shows that drug-induced restoration of pain-depressed behaviors provides increased clinical translation with decreased susceptibility to false-positives. Accordingly, the first portion of this dissertation designed a behavioral battery that featured pain-depressed behaviors as well as more conventional pain-stimulated behaviors for testing candidate analgesics in male and female mice. The main findings are as follows. (1) Intraperitoneal injection of …


The Experiences Of Religiously And Spiritually Diverse Counselors And Psychotherapists Who Work With Survivors Of Sexual Violence, John M. Waters Jan 2022

The Experiences Of Religiously And Spiritually Diverse Counselors And Psychotherapists Who Work With Survivors Of Sexual Violence, John M. Waters

Theses and Dissertations

The purpose of this qualitative study was to examine the lived experiences of religiously and spiritually diverse counselors and psychotherapists who work with survivors of sexual violence. The researcher used a transcendental phenomenological approach to understand how the participants engaged their religious and/or spiritual identity to cope with the traumatic stress that accompanies continuous exposure to their clients’ trauma narratives over time. As the only study that has examined these phenomena qualitatively, the present study aimed to enhance counselors and counselor educators’ understanding of the ways that religiously and spiritually diverse counselors make meaning of their experiences. The researcher collected …


Impact Of The Covid-19 Pandemic On Child Anxiety Symptoms: The Influence Of The Caregiver-Child Relationship, Rebecca Hoppe Jan 2022

Impact Of The Covid-19 Pandemic On Child Anxiety Symptoms: The Influence Of The Caregiver-Child Relationship, Rebecca Hoppe

Theses and Dissertations

Research suggests that youth are dealing with a myriad of worries during the COVID-19 pandemic (Ellis et al., 2020), which highlights the need for investigations focused on child anxiety. However, to date little research has examined children’s anxiety in the COVID-19 pandemic nor the potential protective effects of the caregiver-child relationship. Therefore, this research aimed to contribute to the literature by investigating the influence of COVID-19 related stressors in younger children and leveraging children’s report of their own attachment security within their relationship with their caregiver and mental health. The current study used a national, quantitative survey of young children …


Development And Validation Of A Volunteer Adult Literacy Tutor Perception Feedback Scale, Robert Craig Jan 2022

Development And Validation Of A Volunteer Adult Literacy Tutor Perception Feedback Scale, Robert Craig

Theses and Dissertations

This exploratory study developed and validated a Volunteer Adult Literacy Tutor Perception Feedback Scale (VALTPFS). The VALTPFS is a self-report questionnaire that measures the perceptions of one-on-one adult literacy tutors about their values, knowledge sharing, and satisfaction. This instrument is designed to assess the perceptions of adults who volunteer to provide literacy instruction to tutees who are U.S. born native English language speaking adults. The theoretical framework used to inform the development of the VALTPFS is the community of practice (CoP). The CoP framework was used to identify subscales from instruments with established psychometric credentials to operationalize the VALTPFS. As …


Therapeutic Approaches For Respiratory Distress Syndrome, Franck J. Kamga Gninzeko Jan 2022

Therapeutic Approaches For Respiratory Distress Syndrome, Franck J. Kamga Gninzeko

Theses and Dissertations

Respiratory distress syndrome (RDS) is characterized by shortness of breath and low oxygen levels. RDS affects the neonatal and adult populations. In the neonatal population, RDS can be classified as NRDS (Neonatal respiratory distress syndrome), while in adults, it is known as ARDS (acute respiratory distress syndrome). This dissertation examines a therapeutic approach to NRDS and a mechanistic approach to ARDS with in vivo and in vitro models of lung injury. NRDS is characterized by a deficiency or lack of surfactant. Surfactant is an essential compound composed of phospholipids and proteins to prevent the lungs from collapsing. There are several …


Race, Weight, Gender And The Embodied (Odied, Odied) Consciousness Of Big-Bodied Black Women Educators: A Phenomenological Study, Kendra D. Johnson Jan 2022

Race, Weight, Gender And The Embodied (Odied, Odied) Consciousness Of Big-Bodied Black Women Educators: A Phenomenological Study, Kendra D. Johnson

Theses and Dissertations

Big-Bodied Black women in the United States have perpetually navigated the veritable dichotomy of being hyper-visible and invisible (Beauboeuf-Lafontant, 2003; Fleetwood, 2001; Strings, 2019). Fat Black female bodies have borne the burden of exaggerated tropes and exploitation throughout history, stripping them of their femininity and humanity and resulting in a unique form of objectification (Strings, 2019). Inconsistent messages about BBWs, their bodies, and their value in society have endured for generations. They have been essential in constructing the controlling images of Black womanhood in the U.S. (Collins, 2000). The controlling images all evoked thoughts about the suitability of Black women …


Effect Of Clear Aligner Attachment Design On Extrusion Of Maxillary Lateral Incisors: A Randomized Clinical Trial, Justin Groody Jan 2022

Effect Of Clear Aligner Attachment Design On Extrusion Of Maxillary Lateral Incisors: A Randomized Clinical Trial, Justin Groody

Theses and Dissertations

Introduction: The aims of this randomized clinical trial were to compare the efficacy of extrusion of maxillary lateral incisors among “optimized”, rectangular “horizontal”, rectangular horizontal “incisally beveled”, rectangular horizontal “gingivally beveled” attachments, and to provide a clinically relevant recommendation for attachment planning for extrusion of maxillary lateral incisors during aligner treatment.

Methods: 30 16-to-58 year old Invisalign patients and 56 maxillary lateral incisors requiring extrusion were randomly allocated to one of four attachment groups (optimized, horizontal, incisally beveled, and gingivally beveled). Participants were recruited from two private practice offices and the Virginia Commonwealth University School of Dentistry. The outcome assessor …


Culturally Relevant Coping Strategies Within Bicultural Latine College Students In The Face Of Anti-Immigrant Sentiment And Policy, Cindy M. Hernandez Jan 2022

Culturally Relevant Coping Strategies Within Bicultural Latine College Students In The Face Of Anti-Immigrant Sentiment And Policy, Cindy M. Hernandez

Theses and Dissertations

Despite their protective potential against anti-immigrant sentiment and policy, the connections between bicultural identity development and culturally relevant coping among temporarily documented Latinx college students remain unstudied. Therefore, this study (a) describes culturally relevant coping strategies used by bicultural Latinx college students, (b) examines the role cultural identity plays in bicultural Latinx college students’ coping strategies, and (c) illuminates the role institutional level systems play in liminally-documented college students’ coping with anti-immigrant sentiment and policy. Participants in this study included 16 Latine college students (Mage = 21.19, SD = 3.21) with DACA (n = 14) or TPS (n = …