Digital Commons Network^™

Csf Tau Microtubule-Binding Region Identifies Pathological Changes In Primary Tauopathies, Kanta Horie, Nicolas R Barthélemy, Yingxin He, Albert A Davis, Celeste M Karch, Richard J Perrin, Rama K Koppisetti, Faris Shaikh, Nupur Ghoshal, Randall J Bateman, Chihiro Sato, Et Al.

2020-Current year OA Pubs

Despite recent advances in fluid biomarker research in Alzheimer's disease (AD), there are no fluid biomarkers or imaging tracers with utility for diagnosis and/or theragnosis available for other tauopathies. Using immunoprecipitation and mass spectrometry, we show that 4 repeat (4R) isoform-specific tau species from microtubule-binding region (MTBR-tau

Promoting Dementia Friendly Skies: Air Travel Experiences And Occupational Therapy Innovation, A Warren, K Turner

School of Health Professions

Air travel often connects people with significant people and places, facilitating engagement in meaningful occupations. Anecdotal and growing research evidence highlights that some people living with dementia have experienced barriers to flying. This presentation will outline research led by occupational therapists to promote accessibility to air travel for this group.

The Expression Of Acat1 In Oral Squamous Cell Carcinoma And The Adjacent Pre-Tumour Tissue, Hadis Firouzpour, Seyed Mohammad Shokrolahi, Ekaterina Bourova-Flin, Samira Derakhshan, Zahra Shahsavari, Abbas Karimi, Hassan Mir Mohammad Sadeghi, Afsaneh Goudarzi

BioMedicine

Background: Altered acetyl CoA acetyltransferase 1 (ACAT1) expression has been reported in diverse cancers. However, the expression of ACAT1 and its prognostic value in oral squamous cell carcinoma (OSCC) has remained unexplored. Materials and methods: In this study, the expression of ACAT1 was analysed by immunohistochemistry (IHC) in 61 OSCC patients and compared between OSCC and adjacent pre-tumour tissue of 21 patients. Results: The expression of ACAT1 in OSCC tumours is heterogeneous between patients. More specifically, 52.38% of the patients show low expression of ACAT1 in both tumour and adjacent pre-tumour tissues, 9.52% of the patients show high expression of …

The Effect Of Ghrelin On Antioxidant Status In The Rat’S Model Of Alzheimer's Disease Induced By Amyloid-Beta, Fatemeh Sarlaki, Zahra Shahsavari, Fatemeh Goshadrou, Faezeh Naseri, Mohammad Keimasi, Majid Sirati-Sabet Dr

BioMedicine

Alzheimer's disease (AD) is a neurodegenerative disorder associated with amyloid-beta (Aβ) plaque formation and oxidative stress in the brain. Ghrelin has been proven to exert antioxidant activity and neuroprotection in different neurological diseases. This study is going on to examine the effect of ghrelin on antioxidant status in the rat’s model of AD induced by Aβ. Cognitive impairment was induced by intra-hippocampal administration of Aβ (10 µg) in Wistar rats and ghrelin (80 μg/kg) was administrated intraperitoneal for ten consecutive days. Behavior was assessed with Morris water maze and passive avoidance tests. Malondialdehyde (MDA) level as a marker of lipid …

Clinicopathological And Prognostic Significance Of Cxcr4 Expression In Osteosarcoma: A Meta-Analysis, I Gusti Ngurah Ananda Wira Kusuma, Grace Yulia Alphani Yapson, John Nolan, I Gede Eka Wiratnaya, I Gede Putu Supadmanaba

BioMedicine

Background: The C-X-C Motif Chemokine Receptor (CXCR4) is an oncogene that has been widely studied and associated with worse clinicopathological features and prognosis outcomes in many types of cancer. Besides that, significance of CXCR4 expression on clinicopathological features and prognostic factors in osteosarcoma (OS) requires further validation.

Aim: We conducted a meta-analysis to evaluate the association between positive CXCR4 expression with clinicopathological features and prognosis in OS.

Methods: Literature searches on Pubmed, Cochrane Library, and Web of Science were conducted systematically up to December 2021 to find relevant references. The effects of CXCR4 expression on clinicopathological characteristics and prognostic were …

Analysis Of Antiquorum-Sensing And Antibiofilm Activity By Pomelo Peel Extract (Citrus Maxima) On Multidrug-Resistance Pseudomonas Aeruginosa, I Gede Krisna Arim Sadeva, Putri Ayu Wulandari, Aizar Vesa Prasetyo, Luh Putu Nike Wahyuntika, Putu Nindya Krisnadewi Rahadi, I Gede Aswin Parisya Sasmana, I Made Rhamandana Putra, Agus Eka Darwinata

BioMedicine

Pseudomonas aeruginosa is gram-negative bacteria with high adaptability by forming biofilms and quorum-sensing mechanisms to avoid immune responses and antimicrobial agents which tend to develop into Multidrug Resistance (MDR) related to Healthcare-Associated Infection (HAI) with a prevalence of 3,8% in Indonesia and a mortality of up to 69%. Polyphenol compounds found in pomelo peels (Citrus maxima) have been shown to have antibiofilm and antiquorum-sensing effects but are less investigated. Therefore, this study aimed to investigate those effects on MDR P. aeruginosa. In vitro study design is performed to evaluate the inhibition effect of ethanolic extract on bacterial …

Crosstalk Between Fatty Acid Metabolism And Tumour-Associated Macrophages In Cancer Progression, Noorzaileen Eileena Zaidi, Nur Aima Hafiza Shazali, Thean Chor Leow, Mohd Azuraidi Osman, Kamariah Ibrahim, Nik Mohd Afizan Nik Abd Rahman

BioMedicine

Over the last few decades, cancer has been regarded as an independent and selfsustaining progression. The earliest hallmarks of cancer comprise of sustaining proliferative signalling, avoiding growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, and activating invasion and metastasis. Nonetheless, two emerging hallmarks are being described: aberrant metabolic pathways and evasion of immune destruction. Changes in tumour cell metabolism are not restricted to tumour cells alone; the products of the altered metabolism have a direct impact on the activity of immune cells inside the tumour microenvironment, particularly tumour-associated macrophages (TAMs). The complicated process of cancer growth is orchestrated …

Is Autologous Platelet Activation The Key Step In Ovarian Therapy For Fertility Recovery And Menopause Reversal?, Natalie S. Rickers, E. Scott Sills

BioMedicine

Platelets are a uniquely mammalian physiologic feature. As the only non-marine vertebrates to experience menopause, humans have a substantial post-reproductive lifespan and are believed to have a limited, non-renewable oocyte supply. Ovarian reserve typically declines after about age 35yrs, marking losses which cannot be recovered by available fertility medications. When in vitro fertilization fails due to low or absent ovarian response, gonadotropin adjustments are often ineffectual and if additional oocytes are occasionally harvested, egg quality is usually poor. This problem was confronted by Greek researchers who developed a new surgical method to insert autologous platelet-rich plasma (PRP) into ovaries; the …

Acknowledgment Of Reviewers

Journal of Food and Drug Analysis

No abstract provided.

Inorganic Arsenic Speciation Analysis In Food Using Hplc/Icp-Ms: Method Development And Validation, Yu-Cheng Lai, Yi-Chen Tsai, Yu-Ning Shin, Ya-Chun Chou, Ying-Ru Shen, Nu-Ching Lin, Shu-Han Chang, Ya-Min Kao, Su-Hsiang Tseng, Der-Yuan Wang

Journal of Food and Drug Analysis

Arsenic (As) compounds can be classified as organic or inorganic, with inorganic arsenic (iAs) having significantly higher toxicity than organic As. As may accumulate in food materials that have been exposed to As-contaminated environments. Thus, the “Sanitation Standard for Contaminants and Toxins in Foods” published by the Ministry of Health and Welfare set the standard limits for iAs content in rice, seaweed, seafood, and marine oils to safeguard public health. Therefore, a robust analytical method must be developed to selectively and quantitatively determine iAs content in rice, seaweed, seafood, and marine oils. Herein, we reported and verified the method of …

Optimization Of Quechers And High Performance Liquid Chromatography-Fluorescence Detection Conditions To Assess The Impact Of Preparation Procedures On Eu Priority Pahs In Coffee Samples And Their Pahs Consumption Risk, Ying-Chun Wan, Zwe-Lin Kong, Yu-Hsuan Chao, Chia-Fang Teng, Deng-Jye Yang

Journal of Food and Drug Analysis

The good performance conditions for determination of EU priority PAHs in coffee samples were established to evaluate the effects of roasting degree on the PAHs in coffee beans and the brewing methods on the PAHs transfer from coffee beans to their brews. The consumption risk of the PAHs in coffee products was also assessed. The PAHs levels of the roasted coffee beans were in the order: 923.65 ng/g (dark roast) > 132.20 ng/g (medium roast) > 69.28 ng/g (light roast). Compared with general brewing with the drip bag (PAHs content, 0.30–0.62 ng/mL in coffee brews), the coffee machine brewing (set at 4 …

Effect Of Sterilization Conditions On The Formation Of Furan And Its Derivatives In Canned Foods With Different Substrates, Wen-Xuan Tsao, Bing-Huei Chen, Tsai-Hua Kao

Journal of Food and Drug Analysis

This study explored the effects of sterilization conditions on the formation of furan and its 10 derivatives in canned foods with a sterilizing value (F0) at 4. The contents of furans were determined by SPME arrow-GC-MS/MS, along with the furan precursors analyzed for elucidating the possible mechanism of furan formation. Results revealed that the total furan contents rose substantially in canned meat paste, tomato mackerel, chicken puree, tomato paste, pineapple slice, pineapple juice and carrot juice following sterilization. However, the total furan content did not change significantly ( p > 0.05) in canned oily mackerel, but decreased significantly ( p < 0.05) in canned apple puree after sterilization. With the exception of apple puree and pineapple slice, all the other canned foods showed a higher total furan content under low-temperature-long-time condition than that under high-temperature-short-time condition. Following heating, only the furan level showed a large increase in chicken puree, meat paste and tomato mackerel, whereas in canned fruit- and vegetable-based foods, the contents of furan and furfural showed a pronounced increase. The levels of alkylated furans were higher in sterilized samples containing high level of amino acid, while that of oxygenated furans were higher in sterilized samples containing high level of reducing sugar.

Optimum Synthesis Of Au@Ag Nanoparticle As Plasma Amplifier To Detect Trace Concentration Of Afb1 Via Object-Binder-Metal Sers Method, Wenwen Chen, Qiang Chen, Wei Zhang, De Zhang, Zhi Yu, Ying Song, Xiubing Zhang, Dejiang Ni, Pei Liang

Journal of Food and Drug Analysis

The problem of aflatoxin contamination emerged gradually in the field of food safety. Surface-enhanced Raman spectroscopy (SERS) is an ultra-sensitive and non-destructive spectroscopy technology with extensive application prospects in the detection field. In this paper, with the detection of AFB1 as the target, Au@Ag NPs substrate with uniform morphology and strong SERS effect was prepared. Furthermore, the intermediates formed by hydrogen bonding between AFB1 and melamine facilitate the binding of toxin molecules to the substrate. Moreover, the AFB1-melamine-Au@Ag NPs detection system was established by optimizing the melamine dosage, and the limit of detection can reach 10^-8 mol/L (M). In …

Simple And Rapid Detection Of Ractopamine In Pork With Comparison Of Lspr And Lfia Sensors, Min Ji Lee, Sheik Aliya, Eun-Seon Lee, Tae-Joon Jeon, Mi-Hwa Oh, Yun Suk Huh

Journal of Food and Drug Analysis

This study developed a simple and rapid strategic technique to detect ractopamine (chemical growth-promoting agent) in pork. Two highly sensitive and specific gold nanoparticle-based portable sensors, i.e., localized surface plasmon resonance (LSPR) sensors, and lateral flow immunoassay (LFIA) strips were developed to detect veterinary drug residues in food products, that have detrimental effects on humans. Optimization studies were conducted on several sensor devices to improve sensitivity. Each sensor comprised functionalized gold nanoparticles conjugated with ractopamine antibodies. The LSPR sensor chip achieved excellent detection sensitivity = 1.19 fg/mL and was advantageous for quantitative analysis due to its wide dynamic range. On …

Recent Trends In Analysis Of Mycotoxins In Food Using Carbon-Based Nanomaterials, Bing-Huei Chen, Baskaran Stephen Inbaraj

Journal of Food and Drug Analysis

Mycotoxins (MYTs), a class of low molecular weight secondary metabolites produced by filamentous fungi in food and feed, pose serious global threat to both human health and world economy. Due to their mutagenic, teratogenic, carcinogenic and immunosuppressive effects, the International Agency for Research on Cancer has classified various MYTs under Group 1 to 3 category with aflatoxins being designated under Group 1 category (carcinogenic to humans). Also, the presence of MYTs in trace amounts in diverse food matrices necessitates exploration of highly sensitive methods for onsite analysis. Although conventional chromatographic methods are highly sensitive, they are expensive, tedious and cannot …

Recent Advances In Immunoassay-Based Mycotoxin Analysis And Toxicogenomic Technologies, Winnie-Pui-Pui Liew, Mohd-Redzwan Sabran

Journal of Food and Drug Analysis

The co-occurrence and accumulation of mycotoxin in food and feed constitutes a major issue to food safety, food security, and public health. Accurate and sensitive mycotoxins analysis can avoid toxin contamination as well as reduce food wastage caused by false positive results. This mini review focuses on the recent advance in detection methods for multiple mycotoxins, which mainly depends on immunoassay technologies. Advance immunoassay technologies integrated in mycotoxin analysis enable simultaneous detection of multiple mycotoxins and enhance the outcomes’ quality. It highlights toxicogenomic as novel approach for hazard assessment by utilizing computational methods to map molecular events and biological processes. …

Analysis Of Highly Polar Pesticides In Foods By Lc-Ms/Ms, Wan-Rou Liao, Kuan-Lu Wu, Kun-Hao Chiang, Chieh-En Teng, Sung-Fang Chen

Journal of Food and Drug Analysis

Highly polar pesticides (HPP) are a group of pesticides that are characterize as low Log Kow. Many high-throughput multi-residue analysis methods based on liquid chromatography-tandem mass spectrometry (LC-MS/MS) for the simultaneous determination of such polar pesticides have been proposed. In this article, we summarize the various sample preparation methods including quick polar pesticides (QuPPe), dispersive solid phase extraction (dSPE), solid phase extraction (SPE) and QuEChERS (Quick, Easy, Cheap, Effective, Rugged and Safe), especially for QuPPe, which are mainly used for the determination of HPP in foods. In addition, we summarize LC-based separation methodologies that are currently used for the analysis …

Microbial Toxins In Fermented Foods: Health Implications And Analytical Techniques For Detection, Khadijah Fayyaz, Asad Nawaz, Amin N. Olaimat, Kashif Akram, Umar Farooq, Mehreen Fatima, Shahida Anusha Siddiqui, Insha Shakeel Rana, Mahnoor Mahnoor, Hafiz Muhammad Shahbaz

Journal of Food and Drug Analysis

Recently, demand for fermented foods has increased due to their improved nutritional value, taste, and health-promoting properties. Worldwide consumption of these products is increasing. Fermented foods are generally safe for human consumption. However, some toxins, primarily biogenic amines (putrescine, phenylethylamine, histamine, tyramine, and cadaverine), mycotoxins (fumonisins, aflatoxins, ochratoxin A, zearalenone, and trichothecenes), and bacterial toxins (endotoxins, enterotoxins, and emetic toxins) can be produced as a result of using an inappropriate starter culture, processing conditions, and improper storage. These toxins can cause a multitude of foodborne illnesses and can lead to cardiovascular aberration and adverse gastrointestinal symptoms. Analytical techniques are in …

Recent Advances In The Analysis Of Polycyclic Aromatic Hydrocarbons In Food And Water, Bing-Huei Chen, Baskaran Stephen Inbaraj, Kuo-Chiang Hsu

Journal of Food and Drug Analysis

Polycyclic aromatic hydrocarbons (PAHs), a class of harmful and persistent organic contaminant, are widely distributed in the environment and eventually accumulated in water and food. Also, they are formed in different varieties and varying amounts during processing of food depending on the food composition, cooking method and processing condition. According to the International Agency for Research on Cancer (IARC), various PAHs are classified under Group 1 to 3 category, with Group 1 designated as carcinogenic to humans, Group 2A as probable carcinogen, Group 2B as possible carcinogen and Group 3 as noncarcinogenic. Therefore, it is imperative to develop rapid and …

Preface, Bing-Huei Chen

Journal of Food and Drug Analysis

No abstract provided.

The Degree To Which Secondary School Students In Jordan Possess Digital Citizenship Skills, Dareen Abdelhadi, Youssef Arouri

Jerash for Research and Studies Journal مجلة جرش للبحوث والدراسات

The purpose of this study was to identify the degree to which secondary school students in Jordan possess digital citizenship skills and to identify the extent of statistically significant differences attributed to variables: gender, family monthly income, education system. The researcher used the descriptive survey analysis approach to conduct the study; the study tool (A test) was prepared consisting of (52) items and they were classified according to the nine elements of digital citizenship as follows: digital literacy, digital etiquette, digital laws, digital health and wellness, digital access, digital communications, digital security, digital commerce, digital rights and responsibilities. After verifying …

The Level Of Occupational Stress Among Public School Teachers In Jordan, Khalid Al-Mahasnieh

Jerash for Research and Studies Journal مجلة جرش للبحوث والدراسات

The current study aimed to identify the level of occupational pressures that secondary school teachers are exposed to in Jerash Directorate of Education, and proposing some solutions to relieve such kind of pressures.

To achieve the objectives of the study, the researcher adopted the descriptive analytical method, both quantitative and qualitative, the study tool was a questionnaire contains (30) paragraphs, and an open question to suggest some possible solutions. The tool was applied to a sample of (274) secondary school teachers in Jerash Directorate of Education.

A set of suggestions were also presented, which it is hoped will work to …

Psychological Stress And Its Relationship To Self-Esteem And Life Quality Among Battered Women At Kuwait, Fatima Al-Adwan, Abtesam Al-Rashedi

Jerash for Research and Studies Journal مجلة جرش للبحوث والدراسات

The aim of the study was to identify the level of psychological stress and its relationship to self-esteem and life quality among Battered Women at Kuwait. The study sample consisted of (68) violated womenat Kuwait. For the purposes of the current study, the researcher developed the measures of psychological stress, self-esteem, and life quality of Battered Women. The results of the study showed that the level of psychological stresswas high, self-esteem and life quality was low. The results also showed there is an inverse correlation between psychological stress and self-esteem and life quality. The study recommends that researchers and specialists …

The Effectiveness Of A Counseling Program Based On Positive Psychology In Reducing Depression Among Orphan Students, Sahar Al-Menshawi

Jerash for Research and Studies Journal مجلة جرش للبحوث والدراسات

The study aimed to investigate the effectiveness of a counseling program based on positive psychology strategies in reducing depression among secondary school students. The sample consisted of (30) students who obtained the lowest marks in the study scale (depression). And distributing them randomly into two groups: a pilot on which the extension program was applied, and a control who was not exposed to the extension program As each group included (15), and the study also relied on the quasi-experimental approach.

To get acquainted with the effectiveness of the counseling program among the students of the study sample, the researcher used …

The Effectiveness Of The Three Stones Jumping Program (S.S.T.P) Directed At Mothers Of Children With Autism Spectrum Disorder In Reducing Behavioral Problems Among Their Children Enrolled In Special Education Centers According To The Variables Of Family Size And Mother’S Educational Level, Daree. Abu-Harb, Nadia Al-Srour

Jerash for Research and Studies Journal مجلة جرش للبحوث والدراسات

The study aimed to identify the effect of the Stepping Stone Triple P (SSTP) directed at mothers of children with autism spectrum disorder enrolled in special education centers in reducing the behavioral problems of their children, attributed to the variables of the educational level of the mother and the size of the family members. The study used the quasi-experimental approach. The sample of the study consisted of (30) mothers of children with autism spectrum disorder who were enrolled in one of the special education centers in the capital Amman, and they were divided into (15) mothers for the control group …

The Effectiveness Of A Preventive Collective Counseling Program In Reduce Cyberbullying Among Students At The Upper Primary Stage At Private Schools In Jordan, Rula Abu-Baker, Sahib Al-Janabi

Jerash for Research and Studies Journal مجلة جرش للبحوث والدراسات

The study aimed to identify The Effectiveness of a Preventive Collective Counseling Program in Reduce Cyberbullying among Students at the Upper Primary Stage at Private Schools In Jordan, where the semi-experimental approach was used. The study sample consisted of (30) students divided into two groups, one of them being experimental and the other controlling. The cyberbullying scale was used as a study tool, and the study found that there were differences in favor of the experimental group who were exposed to the counseling program compared to the control group members. There were no statistically significant differences between the two applications …

The Impact Of Organizational Mindfulness On Organizational Resilience From The Point Of View Of Managers And Officials Of Departments In The Ministry Of Education, Ahlam Al-Tibakhi

Jerash for Research and Studies Journal مجلة جرش للبحوث والدراسات

The research aims to study the perceptions of employees in the Ministry of Education in Jordan on the impact of organizational mindfulness on organizational resilience, and to achieve this goal this study sought to use a questionnaire, where this questionnaire consisted of two groups as follows: organizational mindfulness items and organizational resilience items. The sample of this study was (377) respondents from the educational sector. In addition, statistical analyzes such as mean, standard deviations, and frequencies were used. In addition, ANOVA tests and correlation coefficient were used to answer the hypotheses of the study.

The study concluded that organizations should …

A Study On The Most Important Problems And Challenges Facing Learners And Teachers In Adult Education And Literacy Centers In Jordan, And Ways To Confront Them, Mahmoud Mashal

Jerash for Research and Studies Journal مجلة جرش للبحوث والدراسات

This study aimed to identify the reality of the services and the educational environment provided to learners in adult education centers and literacy in the directorates of education in Jordan, and to identify the most important problems and challenges facing learners and teachers in these centers in preparation for proposing appropriate solutions that would develop the mechanism of work in education centers Adult literacy, improving the educational services provided to learners, and improving the outputs of these centers.

The sample of the study included a group of teachers and students at adult education and literacy centers in various regions of …

An Islamic Estimate Of The Government Procedures In Countering Covid-19 Pandemic, Anwaar Abodalo

Jerash for Research and Studies Journal مجلة جرش للبحوث والدراسات

The research aims to review the most important procedures taken by governments in order to counter the Covid-19 pandemic, and estimate those procedures depending on sharia principles and provisions, within sharia objectives “Al-Maqased”. The research contains the following topics: Quarantine, Isolate infected people, curfew, social distancing, travel bans, and providing subsidies and exemptions to affected people. The research also included an explanation of the role of the social solidarity system in Islam in countering the epidemic, and reducing its damages.

The research concluded that the previous procedures are accepted in Islamic Sharia, and have origins in Islamic legislation, And that …

2022-11-23_Michiganoverview_Covidvaccinestats, Michigan Department Of Health & Human Services

Michigan COVID-19 Vaccine Data

The COVID Vaccine Dashboard page was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus/resources/covid-19-vaccine/covid-19-dashboard.

First-dose tracker above is for entire Michigan Population. Coverage maps below are for age 5+.

Previously reported numbers of administered vaccine doses may change as new data are received. A possible lag in reporting vaccine doses will result in increases in numbers previously reported.

This report is created by the Michigan Department of Health and Human Services Division of Immunization from data reported to the Michigan Care Improvement Registry (MCIR).

The dashboard contained the tabs Primary Series Doses Administered, Primary Series Doses by Vaccine, …