Digital Commons Network^™

Premature Ovarian Insufficiency In Clpb Deficiency: Transcriptomic, Proteomic And Phenotypic Insights, Elena J Tucker, Julia T Warren, Et Al.

2020-Current year OA Pubs

CONTEXT: Premature ovarian insufficiency (POI) is a common form of female infertility that usually presents as an isolated condition but can be part of various genetic syndromes. Early diagnosis and treatment of POI can minimize comorbidity and improve health outcomes.

OBJECTIVE: We aimed to determine the genetic cause of syndromic POI, intellectual disability, neutropenia, and cataracts.

METHODS: We performed whole-exome sequencing (WES) followed by functional validation via RT-PCR, RNAseq, and quantitative proteomics, as well as clinical update of previously reported patients with variants in the caseinolytic peptidase B (CLPB) gene.

RESULTS: We identified causative variants in CLPB, encoding a mitochondrial …

Determining Epigenetic Memory In Kidney Proximal Tubule Cell Derived Induced Pluripotent Stem Cells Using A Quadruple Transgenic Reprogrammable Mouse, Gabriel Khelifi, Theresa Chow, Jennifer Whiteley, Victoire Fort, Benjamin D Humphreys, Samer M I Hussein, Ian M Rogers

2020-Current year OA Pubs

The majority of nucleated somatic cells can be reprogrammed to induced pluripotent stem cells (iPSCs). The process of reprogramming involves epigenetic remodelling to turn on pluripotency-associated genes and turn off lineage-specific genes. Some evidence shows that iPSCs retain epigenetic marks of their cell of origin and this "epigenetic memory" influences their differentiation potential, with a preference towards their cell of origin. Here, we reprogrammed proximal tubule cells (PTC) and tail tip fibroblasts (TTF), from a reprogrammable mouse to iPSCs and differentiated the iPSCs to renal progenitors to understand if epigenetic memory plays a role in renal differentiation. This model allowed …

Factors Associated With Meeting Physical Activity Guidelines During The Covid-19 Pandemic, Natalia I. Heredia, Michael Machiorlatti, Belinda M. Reininger, Candace Robledo

School of Medicine Publications

Introduction: The COVID-19 pandemic impacted individual physical activity levels. Less is known regarding how factors such as sociodemographic and built environment were associated with physical activity engagement during the pandemic. Understanding these factors is critical to informing future infectious disease mitigation policies that promote, rather than hinder physical activity. The purpose of this study was to assess predictors of physical activity levels during the beginning of the pandemic (April-June 2020), including Stay-at-Home length and orders, neighborhood safety, and sociodemographic characteristics.

Methods: Data included 517 participants who responded to an anonymous online survey. Physical activity was assessed with a modified Godin …

Non-Invasive Tear Break-Up Detection With The Kowa Dr-1Α And Its Relationship To Dry Eye Clinical Severity, Stephen Pflugfelder, Lauren Nakhleh, Yasushi Kikukawa, Shin Tanaka, Takuya Kosugi

Faculty, Staff and Students Publications

The purpose of this study is to compare visual versus software detection of non-invasive tear break-up with the KOWA DR-1α tear interferometer and investigate the relationship between non-invasive tear break-up time (NIBUT) and dry eye clinical severity. Tear interferometry with the KOWA DR-1α, together with a standardized comprehensive ocular surface/tear evaluation, was performed on 348 consecutive eyes. Investigator visually detected or software detected non-invasive tear break-up and NIBUT were measured and compared on a subset of these examinations. The relationship between software-detected NIBUT and categorical dry eye severity based on irritation symptoms and corneal and conjunctival dye staining scores was …

Multi-Disciplinary Biopsychosocial Approach In Low Back Pain Benchmark Study, Liza Beth Cocanougher Short Rn, Ms

MSN Capstone Projects

Low back pain (LBP) is the third most common reason people seek care in America and is the primary reason for missed work days. Working in a pain clinic for eight years and managing research studies directed toward improving low back pain in patients was the motivation for choosing the evidence based intervention in this population. The health care professionals (HCP) in the pain clinic usually have a conversation with the patients who have acute or subacute onset of LBP about their disease and give them a written handout with exercises and ask them to perform these exercises at home. …

Piperine Attenuates Cigarette Smoke-Induced Oxidative Stress, Lung Inflammation, And Epithelial-Mesenchymal Transition By Modulating The Sirt1/Nrf2 Axis, Pritam Saha, Sneha Durugkar, Siddhi Jain, P A Shantanu, Samir R Panda, Aishwarya Jala, Sharad Gokhale, Pawan Sharma, V G M Naidu

Center for Translational Medicine Faculty Papers

Piperine (PIP) is a major phytoconstituent in black pepper which is responsible for various pharmacological actions such as anti-inflammatory, antioxidant, and antitumor activity. To investigate the effects and mechanisms of PIP on cigarette smoke (CS)-induced lung pathology using both in-vitro and in-vivo models. BEAS-2B and A549 cells were exposed to CS extract (CSE) for 48 h; BALB/c mice were exposed to CS (9 cigarettes/day, 4 days) to induce features of airway disease. PIP at doses of (0.25, 1.25, and 6.25 µM, in vitro; 1 and 10 mg/kg, in vivo, i.n) and DEX (1 µM, in vitro; 1 mg/kg, in vivo, …

The Association Of Gabapentin Initiation And Neurocognitive Changes In Older Adults With Normal Cognition, Gyeon Oh, Daniela Claudia Moga, David W. Fardo, Erin L. Abner

Sanders-Brown Center on Aging Faculty Publications

Background: Gabapentin is increasingly prescribed to older adults, which raises concerns about its potential to cause neurocognitive changes. Therefore, we aimed to examine the association of gabapentin use with neurocognitive changes (i.e., cognitive decline, functional status decline, and motor function change) in older adults.

Methods: We conducted a retrospective cohort study using the National Alzheimer’s Coordinating Center Uniform Data Set (UDS; September 2005-March 2021 data freeze). From the eligible sample (≥age 65 years), we identified cognitively normal new-users of gabapentin and the visit they initiated gabapentin (i.e., index visit). Initiators were matched to randomly selected nonusers on year …

The Play Workforce In Wales – An Exploratory Demographic Study, Pete King, Justine Howard Dr

International Journal of Playwork Practice

An online survey of 211 playworkers, 90 childcare and early years workers, and 90 ‘other play’ professionals provided demographic data from 391 people involved in the play workforce in Wales. This was the first extensive survey of the Welsh play workforce since 2008 and was part of a larger Welsh play workforce study. Results of the study found the play workforce in Wales is predominately white, female with no disabilities. Differences within the play workforce exist in relation to the average age where playworkers are younger compared to childcare/early years workers and ‘other play’ professionals. There is a significant difference …

Rana Kapoor Vs Directorate Of Enforcement, Sudhir Kumar Jain

Documents

No abstract provided.

Evaluating The Activity Of Ultrasound On Biofilm Formation By Acinetobacter Baumannii Isolated From Clinical Specimens, Shymaa Ali, Halah H. Al-Haideri, Amna M. Al Hishimi

Baghdad Science Journal

Acinetobacter baumannii received attention for its multi-drug resistant associated with many severe infections and outbreaks in clinical environment. The aims of the study are to investigate the antibiotic susceptibility profile of clinically isolated A. baumannii, biofilm production, and the efficiency of Low Frequency Ultrasound (LFU) and honey to attenuate biofilm production. A total of 100 samples were taken from different sources from Baghdad hospitals. The susceptibility patterns revealed the percentage of pan drug resistant (PDR) isolates were 1.5 %, 72.7 % were extended drug resistant (XDR), 16.7 % were multidrug resistant (MDR), and 9.1 % were non MDR and sensitive …

Chemical Explosion, Covid-19, And Environmental Justice: Insights From Low-Cost Air Quality Sensors, Guning Liu, Katie Moore, Wei-Chung Su, George L Delclos, David Gimeno Ruiz De Porras, Bing Yu, Hezhong Tian, Bin Luo, Shao Lin, Grace Tee Lewis, Elena Craft, Kai Zhang

Faculty, Staff and Student Publications

OBJECTIVES: to examine the impact of the Intercontinental Terminals Company (ITC) fire and COVID-19 on airborne particulate matter (PM) concentrations and the PM disproportionally affecting communities in Houston using low-cost sensors.

METHODS: We compared measurements from a network of low-cost sensors with a separate network of monitors from the Environmental Protection Agency (EPA) in the Houston metropolitan area from Mar 18, 2019, to Dec 31, 2020. Further, we examined the associations between neighborhood-level sociodemographic status and air pollution patterns by linking the low-cost sensor data to EPA environmental justice screening and mapping systems.

FINDINGS: We found increased PM levels during …

Factors Associated With Meeting Physical Activity Guidelines During The Covid-19 Pandemic, Natalia I Heredia, Michael Machiorlatti, Belinda M Reininger, Candace Robledo

Faculty, Staff and Student Publications

INTRODUCTION: The COVID-19 pandemic impacted individual physical activity levels. Less is known regarding how factors such as sociodemographic and built environment were associated with physical activity engagement during the pandemic. Understanding these factors is critical to informing future infectious disease mitigation policies that promote, rather than hinder physical activity. The purpose of this study was to assess predictors of physical activity levels during the beginning of the pandemic (April-June 2020), including Stay-at-Home length and orders, neighborhood safety, and sociodemographic characteristics.

METHODS: Data included 517 participants who responded to an anonymous online survey. Physical activity was assessed with a modified Godin …

The Future Of Our Economy - Part I, Ishrat Husain Dr.

Faculty Research - Newspaper and Magazine Articles

The future of any economy is closely linked with its present and the past. Pakistan’s economic past has gone through different phases with impressive growth and poverty reduction in the 1960s, 1980s, 2000-2007 and 2014-16, and 2020-22. The immediate precarious situation where both consumer and business confidence are at the lowest ebb, international ratings and market sentiment are negative and foreign exchange constraints are binding, if projected into the future and discounting the past, may result in an extremely dismal outlook. Should the present assumptions be carried forward as they are? Would these circumstances – both external and internal – …

A Retrospective Comparative Study Of Sodium Fluoride Na18f-Pet/Ct And 68ga-Psma-11 Pet/Ct In The Bone Metastases Of Prostate Cancer Using A Volumetric 3-D Radiomic Analysis, Kalevi Kairemo, Aki Kangasmäki, Srinivasan Cheenu Kappadath, Timo Joensuu, Homer A Macapinlac

Faculty, Staff and Student Publications

Bone is the most common metastatic site in prostate cancer (PCa). 68Ga-PSMA-11 (or gozetotide) and sodium fluoride-18 (Na18F) are rather new radiopharmaceuticals for assessing PCa-associated bone metastases. Gozetotide uptake reflects cell membrane enzyme activity and the sodium fluoride uptake measures bone mineralization in advanced PCa. Here, we aim to characterize this difference and possibly provide a new method for patient selection in targeted therapies. Methods: The study consisted of 14 patients with advanced PCa (M group > 5 lesions), who had had routine PET/CT both with PSMA and NaF over consecutive days, and 12 PCa patients with no skeletal metastases (N). …

Oxphos Promotes Apoptotic Resistance And Cellular Persistence In Th17 Cells In The Periphery And Tumor Microenvironment, Hanna S Hong, Nneka E Mbah, Mengrou Shan, Kristen Loesel, Lin Lin, Peter Sajjakulnukit, Luis O Correa, Anthony Andren, Jason Lin, Atsushi Hayashi, Brian Magnuson, Judy Chen, Zhaoheng Li, Yuying Xie, Li Zhang, Daniel R Goldstein, Shannon A Carty, Yu Leo Lei, Anthony W Opipari, Rafael J Argüello, Ilona Kryczek, Nobuhiko Kamada, Weiping Zou, Luigi Franchi, Costas A Lyssiotis

Faculty, Staff and Student Publications

T cell proliferation and cytokine production are bioenergetically and biosynthetically costly. The inability to meet these metabolic demands results in altered differentiation, accompanied by impaired effector function, and attrition of the immune response. Interleukin-17-producing CD4 T cells (TH17s) are mediators of host defense, autoimmunity, and antitumor immunity in the setting of adoptive T cell therapy. TH17s are long-lived cells that require mitochondrial oxidative phosphorylation (OXPHOS) for effector function in vivo. Considering that TH17s polarized under standardized culture conditions are predominately glycolytic, little is known about how OXPHOS regulates TH17 processes, such as their ability to persist and thus contribute to …

A Wind Turbine Fault Diagnosis Method Based On Siamese Deep Neural Network, Jiarui Liu, Guotian Yang, Xiaowei Wang

Journal of System Simulation

Abstract: In order to effectively extract the fault features of time series data in supervisory control and data acquisition (SCADA), considering the advantages of one-dimensional convolutional neural network (1-D CNN) for extracting local time series features and the advantages of long-term memory (LSTM) which can extract long-term dependent features, a method for fault diagnosis of wind turbines based on 1-D CNN-LSTM is proposed. To solve the problem of the scarcity of fault samples of wind turbines based on the siamese network architecture, a wind fault diagnosis method based on siamese 1-D CNN-LSTM is proposed. The proposed siamese 1-D CNN-LSTM …

Effect Of Indoor Environment On Occupant Air Comfort And Productivity In Office Buildings: A Response Surface Analysis Approach, Amit Kant Kaushik, Mohammed Arif, Matt M.G. Syal, Muhammad Qasim Rana, Olugbenga Timo Oladinrin, Ahlam Ammar Sharif, Ala’A Saleh Alshdiefat

School of Art, Design and Architecture

Indoor air quality is a significant factor influencing occupant comfort, health and productivity. Indoor air comfort and its relationship to occupant comfort and productivity are widely documented. Statistical correlation between the two has been highlighted in scientific literature. This paper investigates any unique correlations between non-air quality parameters (such as lux level, temperature, and noise level) and indoor air comfort and presents a study investigating the effect of indoor environmental quality on occupant air comfort and productivity. This study was conducted by collecting data on indoor environmental parameters using remote sensors and an online survey for occupant responses for twelve …

Interventions For Preventing And Ameliorating Cognitive Deficits In Adults Treated With Cranial Irradiation, Matthew A Kirkman, Julia Day, Karin Gehring, Karolis Zienius, David Grosshans, Martin Taphoorn, Jing Li, Paul D Brown

Faculty, Staff and Student Publications

BACKGROUND: Cognitive deficits are common in people who have received cranial irradiation and have a serious impact on daily functioning and quality of life. The benefit of pharmacological and non-pharmacological treatment of cognitive deficits in this population is unclear. This is an updated version of the original Cochrane Review published in Issue 12, 2014.

OBJECTIVES: To assess the effectiveness of interventions for preventing or ameliorating cognitive deficits in adults treated with cranial irradiation.

SEARCH METHODS: For this review update we searched the Cochrane Register of Controlled Trials (CENTRAL), MEDLINE via Ovid, Embase via Ovid, and PsycInfo via Ovid to 12 …

Variation In Human Water Turnover Associated With Environmental And Lifestyle Factors, Yosuke Yamada, Xueying Zhang, Mary E T Henderson, Hiroyuki Sagayama, Herman Pontzer, Daiki Watanabe, Tsukasa Yoshida, Misaka Kimura, Philip N Ainslie, Lene F Andersen, Liam J Anderson, Lenore Arab, Issad Baddou, Kweku Bedu-Addo, Ellen E Blaak, Stephane Blanc, Alberto G Bonomi, Carlijn V C Bouten, Pascal Bovet, Maciej S Buchowski, Nancy F Butte, Stefan G Camps, Graeme L Close, Jamie A Cooper, Richard Cooper, Sai Krupa Das, Lara R Dugas, Simon Eaton, Ulf Ekelund, Sonja Entringer, Terrence Forrester, Barry W Fudge, Annelies H Goris, Michael Gurven, Lewis G Halsey, Catherine Hambly, Asmaa El Hamdouchi, Marije B Hoos, Sumei Hu, Noorjehan Joonas, Annemiek M Joosen, Peter Katzmarzyk, Kitty P Kempen, William E Kraus, Wantanee Kriengsinyos, Robert F Kushner, Estelle V Lambert, William R Leonard, Nader Lessan, Corby K Martin, Anine C Medin, Erwin P Meijer, James C Morehen, James P Morton, Marian L Neuhouser, Theresa A Nicklas, Robert M Ojiambo, Kirsi H Pietiläinen, Yannis P Pitsiladis, Jacob Plange-Rhule, Guy Plasqui, Ross L Prentice, Roberto A Rabinovich, Susan B Racette, David A Raichlen, Eric Ravussin, Leanne M Redman, John J Reilly, Rebecca M Reynolds, Susan B Roberts, Albertine J Schuit, Luis B Sardinha, Analiza M Silva, Anders M Sjödin, Eric Stice, Samuel S Urlacher, Giulio Valenti, Ludo M Van Etten, Edgar A Van Mil, Jonathan C K Wells, George Wilson, Brian M Wood, Jack A Yanovski, Alexia J Murphy-Alford, Cornelia U Loechl, Amy H Luke, Jennifer Rood, Klaas R Westerterp, William W Wong, Motohiko Miyachi, Dale A Schoeller, John R Speakman

Children’s Nutrition Research Center Staff Publications

Water is essential for survival, but one in three individuals worldwide (2.2 billion people) lack access to safe drinking water. Water intake requirements largely reflect water turnover (WT), the water used by the body each day. We investigated the determinants of human WT in 5,604 people from the ages of 8 days to 96 years from 26 countries using isotope tracking (2H) methods. Age, body size, and composition were significantly associated with WT as were physical activity, athletic status, pregnancy, socioeconomic status, and environmental characteristics (latitude, altitude, air temperature, and humidity). People in countries with low human development index (HDI) …

A Real-Time Ultrasound Simulation Platform Using Ray Tracing And Its Integration With Virtual Reality, Bo Peng, Qiang Wang, Ruibing Qing, Lixue Yin, Jingfeng Jiang

Journal of System Simulation

Abstract: In order to further improve the efficacy of ultrasound training and reduce the cost. An ultrasound training system that is integrated with a VR environment is developed. The main contribution of this study is to incorporate the Ray-tracing based ultrasound image simulation approach into a virtual reality environment, taking advantage of immersive VR experience for medical ultrasound training. The simulated ultrasound images obtained by the proposed method are then compared to images that are simulated using a generative adversarial network (GAN) technique and Field II ultrasound simulator. The data show that the ultrasound simulator can produce high-quality simulated …

‘Gentle Humour’ To ‘Savage Satire’: Austen Obituaries On Her Death, Its Centenary And Bicentenary, Annika Bautz

School of Law, Humanities and Social Sciences

This chapter invez stigates cultural perceptions of Austen at three points in time as evidenced through obituary articles published on her death in 1817, at the 1917 centenary, and at the bicentenary in 2017, in order to trace shifting trends in the cultural appreciation of the author. The vantage point here is that of the newspaper obituarist or columnist who may or may not have read Austen ahead of their commissions. Turning to non-specialists can reveal much about an author’s cultural status outside of the academy, where assumptions may be just as, if not more, entrenched. Half of the obituaries …

Immune Phenotypes That Are Associated With Subsequent Covid-19 Severity Inferred From Post-Recovery Samples, Thomas Liechti, Yaser Iftikhar, Massimo Mangino, Margaret Beddall, Charles W Goss, Jane A O'Halloran, Philip A Mudd, Mario Roederer

2020-Current year OA Pubs

Severe COVID-19 causes profound immune perturbations, but pre-infection immune signatures contributing to severe COVID-19 remain unknown. Genome-wide association studies (GWAS) identified strong associations between severe disease and several chemokine receptors and molecules from the type I interferon pathway. Here, we define immune signatures associated with severe COVID-19 using high-dimensional flow cytometry. We measure the cells of the peripheral immune system from individuals who recovered from mild, moderate, severe or critical COVID-19 and focused only on those immune signatures returning to steady-state. Individuals that suffered from severe COVID-19 show reduced frequencies of T cell, mucosal-associated invariant T cell (MAIT) and dendritic …

A Study Of Using E-Resources By Research Scholars In Selected Institutions Of Southern Tamilnadu: Research Methodology, Senthur Vel Murugan Librarian

Library Philosophy and Practice (e-journal)

ABSTRACT

Purpose:

In this paper, the philosophical position of the scientist is investigated which will explain the purposes behind the decision approach utilized in this examination. In this way, the principal motivation behind this paper is to exhibit the examination approach and techniques utilized in this investigation to respond to the exploration questions and to accomplish the examination objective.

Design / Methodology/ Approach

Research Design is a groundbreaking strategy indicating the strategies and methodology controlling the specialist to gather their information and investigation their exploration. The most widely recognized research structures that analysts consistently use are exploratory, expressive, and easygoing. …

The Effectiveness Of A Religious Counseling Program In Reducing Symptoms Of Obsessive-Compulsive Disorder Among Philadelphia University Students فاعلية برنامج إرشادي ديني في خفض أعراض الوسواس القهري لدى طلبة جامعة فيلادلفيا, Sanaa Nasser Khawaldeh

Jordanian Educational Journal

Abstract:

The study seeks to identify the effectiveness of a religious counseling program in reducing symptoms of obsessive compulsive disorder among Philadelphia University students. The study population consisted of all students for the academic year 2018/2019, where the obsessive-compulsive measure was applied as a pre-test on students who have desire to participate in the program, they were (60).The sample was chosen from students who received moderate and high scores on the OCD scale were randomly divided into two groups (experimental and control)(20) students each group.To demonstrate the statistical differences significance between means (MANCOVA) was used, also (t) test was used …

Jordanian Efl Sixth-Grade Students’ Attitudes Towards Using Gamification In Reading Comprehension اتجاهات طلاب الصف السادس الأردنیین متعلمي اللغة الانجليزية لغة أجنبية نحو استخدام الألعاب التحفيزية في فهم المقروء, Rami Ali Abu Sa’Aleek, Abdallah Ahmad Bani Abdel Rahman

Jordanian Educational Journal

Abstract:

This study investigated the Jordanian EFL sixth-grade students ’attitudes towards using gamification in reading comprehension lessons. The participants of the study were 35 students from a public school in Jordan. They studied reading comprehension activities through gamification. A questionnaire with 31-items was designed to explore students’ attitudes towards using gamification in reading comprehension lessons. The results indicated that the sixth-grade students had positive attitudes towards the use of gamification in reading comprehensionlessons.

ملخص:

بحيث هذه الدراسة في اتجاهات طلاب الصف السادس الأردنیین متعلمي اللغة الانجليزية لغة أجنبية نحو استخدام الألعاب التحفيزية في دروس فهم المقروء. بلغ عدد المشاركين في …

The Effectiveness Of A Group Counseling Program Based On Feminist Therapy In Improving Self-Assertiveness Of Battered Women فاعلية برنامج إرشادي جمعي يستند إلى العلاج النسّوي في تحسين مستوى توكيد الذات لدى النساء المعنفات, Bara Asaa'd Khatatbeh, Manar Saeed Banimostafa

Jordanian Educational Journal

Abstract:

The current study aimed to examine the effectiveness of a group counseling program based on feminist therapy in improving the self-assertiveness of battered women. The program was applied to a group of women who attend the Islamic Society for Social Services Center, in the AL-Rammtha District, Jordan, and the study sample consisted of (30) battered women, and they were selected based on their low scores on the self-assertiveness scale, and they were randomly distributed into two groups: an experimental group It includes (15) abused women, and a control group includes (15) abused women. To achieve the objectives of the …

The Degree Of Effectiveness Of The (Ma’An Program Prevention Of Violence And Addiction) And Its Relationship To Achieving Safe School Environment From The Principals And Supervisors Point Of View In The Kingdom Of Bahrain درجة فاعلية برنامج (معاً لمكافحة العنف والإدمان) وعلاقته بتحقيق بيئة مدرسية آمنة من وجهة نظر مديري مدارس مملكة البحرين ومشرفيها, Ali Kdhem Al Sanadi, Munera Mamoud Al Shorman

Jordanian Educational Journal

Abstract:

The current study aimed to identify the degree of effectiveness of (the Ma’an Program Prevention of Violence and Addiction) and its relationship to achieve safe school environment from the principals and supervisors of schools point of view in the Kingdom of Bahrain, where the quantitative descriptive approach was used, the study sample included (373) principals and supervisors from the schools of the Kingdom of Bahrain in which it was applied. The program, where the study tool was distributed, which included the domain of effectiveness of the (the Ma’an Program Prevention of Violence and Addiction) and the domain of a …

Vol.50 N.18 November 24th 2022, Voice Media Ventures

Black Voice News

No abstract provided.

Guest Editorial: The Early Adolescence Of Entrepreneurship Research, Jeff Muldoon, Raj V. Mahto, Eric W. Liguori

Rohrer College of Business Departmental Research

No abstract provided.

Sociodemographic Determinants Of Oral Anticoagulant Prescription In Patients With Atrial Fibrillations: Findings From The Pinnacle Registry Using Machine Learning, Zahra Azizi, Andrew T. Ward, Donghyun J. Lee, Sanchit S. Gad, Kanchan Bhasin, Robert J. Beetel, Tiago Ferreira, Sushant Shankar, John S. Rumsfeld, Salim S. Virani

Office of the Provost

Background: Current risk scores that are solely based on clinical factors have shown modest predictive ability for understanding of factors associated with gaps in real-world prescription of oral anticoagulation (OAC) in patients with atrial fibrillation (AF).
Objective: In this study, we sought to identify the role of social and geographic determinants, beyond clinical factors associated with variation in OAC prescriptions using a large national registry of ambulatory patients with AF.
Methods: Between January 2017 and June 2018, we identified patients with AF from the American College of Cardiology PINNACLE (Practice Innovation and Clinical Excellence) Registry. We examined associations between patient …