Digital Commons Network^™

The Fate Of Early Perichondrial Cells In Developing Bones, Yuki Matsushita, Angel Ka Yan Chu, Chiaki Tsutsumi-Arai, Shion Orikasa, Mizuki Nagata, Sunny Y Wong, Joshua D Welch, Wanida Ono, Noriaki Ono

Faculty, Staff and Student Publications

In endochondral bone development, bone-forming osteoblasts and bone marrow stromal cells have dual origins in the fetal cartilage and its surrounding perichondrium. However, how early perichondrial cells distinctively contribute to developing bones remain unidentified. Here we show using in vivo cell-lineage analyses that Dlx5+ fetal perichondrial cells marked by Dlx5-creER do not generate cartilage but sustainably contribute to cortical bone and marrow stromal compartments in a manner complementary to fetal chondrocyte derivatives under the regulation of Hedgehog signaling. Postnatally, Dlx5+ fetal perichondrial cell derivatives preferentially populate the diaphyseal marrow stroma with a dormant adipocyte-biased state and are refractory to parathyroid …

Genetic And Small-Molecule Modulation Of Stat3 In A Mouse Model Of Crohn's Disease, Prema Robinson, Emily Magness, Kelsey Montoya, Nikita Engineer, Thomas K Eckols, Emma Rodriguez, David J Tweardy

Faculty, Staff and Student Publications

Crohn's disease (CD), is an inflammatory bowel disease that can affect any part of the gastro-intestinal tract (GI) and is associated with an increased risk of gastro-intestinal cancer. In the current study, we determined the role of genetic and small-molecule modulation of STAT3 in a mouse model of CD. STAT3 has 2 isoforms (α, β) which are expressed in most cells in a 4:1 ratio (α: β). STAT3α has pro-inflammatory and anti-apoptotic functions, while STAT3β has contrasting roles. We used an animal model of CD consisting of intrarectal administration of 2,4,6-trinitrobenzene sulfonic acid and examined the severity of CD in …

Inactivation Of Lats1/2 Drives Luminal-Basal Plasticity To Initiate Basal-Like Mammary Carcinomas, Joseph G Kern, Andrew M Tilston-Lunel, Anthony Federico, Boting Ning, Amy Mueller, Grace B Peppler, Eleni Stampouloglou, Nan Cheng, Randy L Johnson, Marc E Lenburg, Jennifer E Beane, Stefano Monti, Xaralabos Varelas

Faculty, Staff and Student Publications

Basal-like breast cancers, an aggressive breast cancer subtype that has poor treatment options, are thought to arise from luminal mammary epithelial cells that undergo basal plasticity through poorly understood mechanisms. Using genetic mouse models and ex vivo primary organoid cultures, we show that conditional co-deletion of the LATS1 and LATS2 kinases, key effectors of Hippo pathway signaling, in mature mammary luminal epithelial cells promotes the development of Krt14 and Sox9-expressing basal-like carcinomas that metastasize over time. Genetic co-deletion experiments revealed that phenotypes resulting from the loss of LATS1/2 activity are dependent on the transcriptional regulators YAP/TAZ. Gene expression analyses of …

Optimal Construction Of A Functional Interaction Network From Pooled Library Crispr Fitness Screens, Veronica Gheorghe, Traver Hart

Faculty, Staff and Student Publications

BACKGROUND: Functional interaction networks, where edges connect genes likely to operate in the same biological process or pathway, can be inferred from CRISPR knockout screens in cancer cell lines. Genes with similar knockout fitness profiles across a sufficiently diverse set of cell line screens are likely to be co-functional, and these "coessentiality" networks are increasingly powerful predictors of gene function and biological modularity. While several such networks have been published, most use different algorithms for each step of the network construction process.

RESULTS: In this study, we identify an optimal measure of functional interaction and test all combinations of options …

Fsec Meeting Minutes November 28, 2022, University Of Rhode Island Faculty Senate

Faculty Senate Executive Committee Minutes

No abstract provided.

The Legality Of Russian Gray-Market Imports, Ruben Attia

Cardozo International & Comparative Law Review (CICLR) Blog

In its efforts to cope with Western sanctions implemented in response of its invasion of Ukraine, Russia launched the parallel imports scheme, allowing the importation of many goods without the consent of their intellectual property right-holder. Such goods are called grey market goods because they have been formulated or packaged for a particular jurisdiction and are imported into a different jurisdiction in contradiction to the brand owner’s intention. The value of parallel imports in Russia may well attain $16 billion by the end of 2022, as reported by Russian Minister of Industry and Trade Manturov. The Russian scheme also protects …

Tritiated Steel Micro-Particles: Computational Dosimetry And Prediction Of Radiation-Induced Dna Damage For In Vitro Cell Culture Exposures, Alice Mentana, Yordenca Lamartinière, Thierry Orsière, Véronique Malard, Mickaël Payet, Danielle Slomberg, Isabella Guardamagna, Leonardo Lonati, Cristian Grisolia, Awadhesh Jha, Laurence Lebaron-Jacobs, Jerome Rose, Andrea Ottolenghi, Giorgio Baiocco

School of Biological and Marine Sciences

Biological effects of radioactive particles can be experimentally investigated in vitro as a function of particle concentration, specific activity and exposure time. However, a careful dosimetric analysis is needed to elucidate the role of radiation emitted by radioactive products in inducing cyto- and geno-toxicity: the quantification of radiation dose is essential to eventually inform dose-risk correlations. This is even more fundamental when radioactive particles are short-range emitters and when they have a chemical speciation that might further concur to the heterogeneity of energy deposition at the cellular and sub-cellular level. To this aim, we need to use computational models. In …

Tax (Dis)Conformity, Reverse Federalism, And Social Justice Reform, Michelle D. Layser

Seton Hall Law Review

No abstract provided.

Crises, Creep, And The Surveillance State, Michal Lavi

Seton Hall Law Review

No abstract provided.

A Move In The Bright Direction: Why Congress Has The Power To Bring The Docket Out Of The Shadows, Kevin C. Amici

Seton Hall Law Review

No abstract provided.

Bmfou Pilot Project Rfc - Request For Change, Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Membrane-Active Cyclic Amphiphilic Peptides: Broad-Spectrum Antibacterial Activity Alone And In Combination With Antibiotics, Eman H. M. Mohammed, Sandeep Lohan, Tarra Ghaffari, Shilpi Gupta, Rakesh K. Tiwari, Keykavous Parang

Pharmacy Faculty Articles and Research

We designed a library of 24 cyclic peptides containing arginine (R) and tryptophan (W) residues in a sequential manner [RnWn] (n = 2–7) to study the impact of the hydrophilic/hydrophobic ratio, charge, and ring size on the antibacterial activity against Gram-positive and Gram-negative strains. Among peptides, 5a and 6a demonstrated the highest antimicrobial activity. In combination with 11 commercially available antibiotics, 5a and 6a showed remarkable synergism against a large panel of resistant pathogens. Hemolysis (HC50 = 340 μg/mL) and cell viability against mammalian cells demonstrated the selective lethal action of 5a against bacteria over …

The Role Pressures For Special Educational Needs Coordinators As Managers, Leaders And Advocates In The Covid-19 Pandemic: Implications For Inclusive Education, E Done

School of Law, Humanities and Social Sciences

This paper aims to provide a literature-based consideration of the role of the Special Needs Educational Coordinator (SENCo) in England during COVID-19 pandemic conditions of school lockdown and partial reopening for children classified as vulnerable. The review indicates that the pressures and tensions already experienced by SENCos (around time, workload, status, and their prescribed dichotomised managerial and strategic role) were intensified under pandemic conditions, risking inadequate or delayed provision for children and young people with special educational needs and disabilities. The review also considers research prompted by related concerns around the exclusion or marginalisation of this group of students, through …

K-12 Racial Equity Work In The Predominantly White Pacific Northwest: Interracial Conversations, Counter-Stories, And Considerations, Bradley Justin Parker

Dissertations and Theses

K-12 public education in the United States, post Brown v. Board of Education (1954), has historically maintained a predominantly White teaching force, and has persistently underserved students of Color in terms of academic, social, and emotional outcomes. Additionally, K-12 school-based racial equity work that strives to address the operation of racism is inconsistent, difficult to measure, and has not demonstrably created more racially equitable experiences or outcomes for students or educators of Color. In this project, I critically explore K-12 school-based efforts towards more racial equity in the predominantly White Pacific Northwest, and I take an intentional and critical look …

Non-Governmental Organization/Non-Profit Organization Impact On Education Policy In Ghana, Sarah Ayikai Okine

Journal of Social, Behavioral, and Health Sciences

Non-Governmental Organizations/Nonprofit Organizations (NGOs/NPOs) are progressively becoming an essential source for government agencies in education worldwide. Developing countries such as Ghana have opened the way through regulations and policies for NGOs/NPOs to contribute to the educational system. Nevertheless, perceived threats and confrontations hinder their ability to support the Ministry of Education (MoE) and partner leaders to fulfill their duties in assisting the government in realizing comprehensive universal primary education. This qualitative case study responded to stakeholders’ perceptions of NGOs/NPOs influence on Ghana’s educational system to better comprehend the dynamic and power of NGOs/NPOs on education in Ghana’s rural communities. The …

The Level Of Efficiency Of Government Health Services In Greater Irbid From The Point Of View Of Its Auditors, Amer Mohammad Maslamani, Ali Anbar, Ammar Muslimani

Jerash for Research and Studies Journal مجلة جرش للبحوث والدراسات

This study aimed to know the level of efficiency of government health services in Greater Irbid from the point of view of their auditors, and their differences according to the different areas of efficiency of their services (public, workers, health), as well as their differences according to their nature (primary center, comprehensive center, hospital). The effect of some variables [the nature of the health institution, the frequency of the visit; vehicle arrival time; arrival time by public transport; distance from the place of residence; The time of receiving treatment]" in the different level of efficiency of government health services services …

The Possibility Of Using Digital Public Relations In Managing Marketing Crises In Light Of The Corona Pandemic: A Field Study In Jordanian Private Universities, Mohammad Abu-Jalil, Abdallah Al-Shamesi, Mohammad Abu Jaleel

Jerash for Research and Studies Journal مجلة جرش للبحوث والدراسات

This study aimed to identify the possibility of using digital public relations in managing marketing crises in light of the Corona pandemic. The study population included Jordanian private universities. As for the sample, it consisted of (150) respondents working in the Public Relations Department in Jordanian private universities. It adopted the descriptive and analytical approach, and used the questionnaire as a tool to collect data, and its validity and reliability were confirmed. The study concluded that there is a possibility of using digital public relations in managing marketing crises in light of the Corona pandemic in Jordanian private universities, and …

The Level Of Psychological Resilience And Tolerance Among Students Who Are Victims Of Bullying In The Capital Amman, Ahed Al-Moubedeen

Jerash for Research and Studies Journal مجلة جرش للبحوث والدراسات

The aim of the current research is to reveal the level of psychological resilience and tolerance among students who are victims of bullying in the capital Amman, and to identify the nature of the relationship between the two variables. The number of students reached (97) and two scales were developed, one of them is for psychological resilience, consisting of (38) items and five dimensions, and the other for measuring tolerance and consisting of (25) items. For the objectives of the current study, and the results of the research concluded that the students who are victims of bullying enjoy a medium …

The Effectiveness Of Counseling Program Based On The Selective Direction Improving The Level Of Psychological Hardness Among A Sample Of Female Teachers In Jordan, Enas Al-Saheli

Jerash for Research and Studies Journal مجلة جرش للبحوث والدراسات

The current study aimed to examining the effectiveness of counselling program based on the selective direction in improving psychological Hardness among a sample of female teachers in Jordan.

The study population consisted of (130) female teacher from secondary school teachers in the Abu Nseir region during the academic year 2019/2020, and two schools were selected using the intentional method; Al-Sarh Secondary School for girls as an experimental group and Princess Basma Secondary School for girls as a control group. The individuals of the two groups were randomly nominated; (15) teacher in each group. This study relied on the semi-experimental method. …

Role For The Jordanian Secondary School To Develop Students Health Awareness, Laith Alzawahreh, Mohammed Alzboon

Jerash for Research and Studies Journal مجلة جرش للبحوث والدراسات

The study aimed to identify the role for the Jordanian secondary school to develop student’s health awareness. To achieve the objectives of the study, the use of the descriptive approach was developed and a tool was developed to achieve its objectives.

The study sample consisted of (350) teachers of secondary school who were selected by the cluster method and distributed in three regions, North, South and Central.

. The results of the study showed that the estimates of the study sample for the role of Jordanian secondary schools in developing health awareness among their students came to a high degree, …

The Prevailing Leadership Styles Among The Principals Of Public Schools Affiliated With The Directorate Education For The First Zarqa District And Its Role In The Performance Of Employee In Light Of The Corona Pandemic, Nariman Al-Akoor

Jerash for Research and Studies Journal مجلة جرش للبحوث والدراسات

The aim of the research is to identify the level of leadership styles prevalent among the principals of public schools affiliated with the Directorate of Education for the first Zarqa District, and to identify the level of performance of its employees, in addition to revealing whether there is a correlation between the leadership styles prevalent among the principals of public schools affiliated with the Directorate of Education for the first Zarqa District and the performance of their employees, by relying on the analytical descriptive approach, through a questionnaire that was distributed to the study sample members, which consisted of teachers …

Social Values And Self-Assertion Among A Sample Of University Students Expected To Graduate, A Comparative Study According To The Variable Of Specialization, Ismail Abu-Hatab

Jerash for Research and Studies Journal مجلة جرش للبحوث والدراسات

The current study aimed to reveal the level of both social values and self-affirmation among a sample of university students and to identify the nature of the relationship between the two variables. One of the psychometric characteristics of the two scales of validity and reliability, and the study was applied in the second semester of the year 2020/2021 and was applied to a random sample of students, numbering (183) male and female university students expected to graduate from Mutah University, and the results of the study found that the level of each Of social values and self-affirmation came average, and …

Distance Learning During The Coronavirus Crisis In Jordanians Universities: Case Study In Jerash University, Mohammad Salem Altarawneh

Jerash for Research and Studies Journal مجلة جرش للبحوث والدراسات

The aim of this study was to An Analytical View of the Factors Affecting in Distance Education during the Coronavirus Crisis: The Point of View of Faculty Members in Jerash University- Jordan. To achieve this objective, questionnaire was prepared for data collection. It was distributed to faculty members for the academic year 20/21. The results showed that in Distance Learning from the point of view of faculty members at Jerash University. The science of technologies possessed by a faculty member is one of the most important factors affecting distance learning. The results showed that there are no statistically significant Differences …

Waqf In Islam And Its Role In The Health Field With Reference To The Case Of Jordan, Ra’Ed Bani Essa, Amer Al-Otoum

Jerash for Research and Studies Journal مجلة جرش للبحوث والدراسات

This study aimed to clarify the role of the endowment in Islam in the health field, as the study dealt with the concept of endowment and health, and the banks of the health endowment, then review the role of the endowment in the field of health, and its contribution to the medical field throughout Islamic history, and then explain the role of endowment institutions in preserving health in the field of health. Contemporary application, and the study relied on the historical method in explaining the role of the endowment in the health field in Islamic history, as well as the …

The Contribution Of Ego Strength And Feeling Of Guilt To Predict The Eudemonic Well -Being Of The Battered Women In Jordan, Hussein Salem Al Sharaa, Nuha Mohammad Al Wazzan

Jerash for Research and Studies Journal مجلة جرش للبحوث والدراسات

The current study aimed to identify the level of ego strength , feeling of guilt and Eudemonic Well- Being of the battered women in Jordan, And the contribution of ego strength and a feeling of guilt in predicting Eudemonic Well-Being, The study sample consisted of (100) battered women with age ranged between (15-55), the researchers developed three measures (ego strength, feeling of guilt, Eudemonic Well-Being), and they a assured the reliability and validity of these measures. The results indicated that the level of ego strength and feeling guilt and Eudemonic Well-Being for the battered women in Jordan were moderate, It …

How Covid-19 Impacts My Life, Yingnan Zhang

In Sickness and in Health in South Texas: Narratives of COVID’s Impact

Family relationship

Ua12/2/1 College Heights Herald: A Place To Call Home, Wku Student Affairs

WKU Administration Documents

Magazine issue of the College Heights Herald for the period October 24 - November 27, 2022.

• Downtown Bowling Green – Restaurants
• Homecoming 2022
• Stone, Damon. WK Liquors Rebuilds After Tornado
• Reed, Bailey. The Making of an SGA President – Cole Bornefeld
• Fountain Row Creates a New Atmosphere Downtown
• Renovated Apartments Offer Home-like Feel – Campus Flats
• Richardson, La’Quan. Kappa Alpha Psi Sponsor Comes Home After 53 Years – Craig Taylor
• Turner, B. Life Continues for Ukrainian Student in the Bluegrass – Mariia Novoselia
• Collins, Michael. Family 5,730 Miles in the Making – Frank Aryee, Immigration, Naturalization

Responsibility And Allocation For Risks Affecting Road’S Construction, Usama H. Issa, Khaled Gamal Marouf, Hamdy B. Faheem

Mansoura Engineering Journal

In many cases, due to the absence of risk allocation models, the owner tended to convey all risks to the contractor who attempted to transfer them to the suppliers and subcontractors. Such attitude is causing a series of conflicts and disputes which will eventually influence the success of the project. In this study, the risk factors associated with the implementation of roads projects were classified based on the responsibility and allocated to the party who can best control them as well as introducing the most effective risk management actions. The risk responsibility was introduced through classifying 88 identified risks into …

Mcconnell, Mickey, Christina Miner

Querying the Past: LGBTQ Maine Oral History Project Collection

Mickey is a graduate student at USM studying Social Work and is an Adult Learning Coach at USM. She is 31 years old and is bi-sexual. Mickey grew up in Brunswick, Maine and her mom raised her and her two sisters. She has been in a seven year relationship with her partner David. She came out about 14 years old, however, it was not well received by her mother, and Mickey remained quiet about it for several years until more recently. Her mother has relaxed more about it, is more accepting and wants her to be happy. As a result …

Data-Driven State Estimation For Improved Wide Area Situational Awareness In Smart Grids, Md Jakir Hossain

USF Tampa Graduate Theses and Dissertations

Wide area situational awareness (WASA) in smart grids includes automatic monitoring, perception and detection of anomalies in these systems. The goal of WASA is to make smart grids aware of their physical and operational state for more effective operational decisions and control. As such, tracking the system's state or state estimation is one of the key objectives of WASA. The extensive integration of cyber elements into smart grids, such as large deployment of various monitoring and measurement devices, provides new opportunities to improve WASA. However, the tight coupling of power grids with cyber components introduces vulnerabilities to cyber and physical …