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2022

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The Search For Spices And Souls: Catholic Missions As Colonial State In The Philippines, Dean C. Dulay Dec 2022

The Search For Spices And Souls: Catholic Missions As Colonial State In The Philippines, Dean C. Dulay

Research Collection School of Social Sciences

A growing literature posits that colonial Christian missions brought schooling to the colonies, improving human capital in ways that persist to this day. But in some places they did much more. This paper argues that colonial Catholic missions in the Philippines functioned as state-builders, establishing law and order and building fiscal and infrastructural capacities in territories they controlled. The mission-as-state was the result of a bargain between the Catholic missions and the Spanish colonial government: missionaries converted the population and engaged in state-building, whereas the colonial government reaped the benefits of state expansion while staying in the capital. Exposure to …


Elucidating Evolutionary Principles With The Traditional Mosuo: Adaptive Benefits And Origins Of Matriliny And “Walking Marriages”, Jose C. Yong, Norman P. Li Dec 2022

Elucidating Evolutionary Principles With The Traditional Mosuo: Adaptive Benefits And Origins Of Matriliny And “Walking Marriages”, Jose C. Yong, Norman P. Li

Research Collection School of Social Sciences

The Mosuo, arguably the last surviving matrilineal society in China, offers interesting insights into kinship practices that support reproduction. In particular, the modes of courtship and reproduction of the traditional Mosuo revolve around a practice known as walking marriages, which involves no contract or obligations, where the men do not use social status or resources to court women, women do not expect commitment from men, and multiple sexual relationships are permitted for both sexes and seldom incite conflict. Children borne from walking marriages are cared for not so much by fathers but rather their mothers' brothers, and wealth and property …


Assessing Subjective Well-Being: A Review Of Common Measures, William Tov, Jun Sheng Keh, Yan Qiang Tan, Qin Ying Joanne Tan, Indra Alam Syah Bin Aziz Dec 2022

Assessing Subjective Well-Being: A Review Of Common Measures, William Tov, Jun Sheng Keh, Yan Qiang Tan, Qin Ying Joanne Tan, Indra Alam Syah Bin Aziz

Research Collection School of Social Sciences

Subjective well-being (SWB) consists of affective components (frequent positive feelings, infrequent negative feelings) and cognitive components (evaluations of life and judgments of satisfaction). We review four commonly used measures of SWB: the Satisfaction with Life Scale (SWLS), Cantril’s ladder, the Positive and Negative Affect Schedule (PANAS), and the Scale of Positive and Negative Experiences (SPANE). We conducted a meta-analysis of the reliability and validity of each measure based on studies published from 1999 to 2019. The SWLS, PANAS, and SPANE generally exhibit acceptable levels of reliability (alphas > .80) across most samples, time frame instructions, and age groups. All measures were …


Responses To Covid-19 Threats: An Evolutionary Psychological Analysis., Stephen M. Colarelli, Tyler J. Mirando, Kyunghee Han, Norman P. Li, Carter Vespi, Katherine A. Klein, Charles P. Fales Dec 2022

Responses To Covid-19 Threats: An Evolutionary Psychological Analysis., Stephen M. Colarelli, Tyler J. Mirando, Kyunghee Han, Norman P. Li, Carter Vespi, Katherine A. Klein, Charles P. Fales

Research Collection School of Social Sciences

Responses to COVID-19 public health interventions have been lukewarm. For example, only 64% of the US population has received at least two vaccinations. Because most public health interventions require people to behave in ways that are evolutionarily novel, evolutionary psychological theory and research on mismatch theory, the behavioral immune system, and individual differences can help us gain a better understanding of how people respond to public health information. Primary sources of threat information during the pandemic (particularly in early phases) were geographic differences in morbidity and mortality statistics. We argue that people are unlikely to respond to this type of …


Choreographing Neutrality: Dance In Cambodia’S Cold War Diplomacy In Asia, 1953-1970, Darlene Machell Espena Dec 2022

Choreographing Neutrality: Dance In Cambodia’S Cold War Diplomacy In Asia, 1953-1970, Darlene Machell Espena

Research Collection School of Social Sciences

This article examines the role of dance in Cambodia’s Cold War diplomacy in Asia from 1953 up until the establishment of the Khmer Republic in 1970. It explores how Sihanouk leveraged Cambodian dances to enact Cambodia’s neutral stance during the Cold War and forge cordial relations with other Asian states. Through an examination of the myriad of dance performances of the Royal Ballet and other Khmer dance troupes within the context of Cambodia’s diplomatic relations in Asia, this paper demonstrates how dance afforded a space for Inter-Asia referencing amidst the Cold War tension in the region. Premised on an interdisciplinary …


Political Signalling And Emissions Trading Schemes In China: Insights From Guangdong Province, Chen Xiang, Terry Van Gevelt Dec 2022

Political Signalling And Emissions Trading Schemes In China: Insights From Guangdong Province, Chen Xiang, Terry Van Gevelt

Research Collection College of Integrative Studies

China's approach to environmental regulation relies heavily on campaign-style enforcement and blunt-force regulation. While considered effective in the short run, this approach is often inefficient and generates unintended regulatory outcomes in the longer run. At the same time, China continues to experiment with the use of market-based approaches that are theoretically more efficient and have the potential to facilitate sustained reductions in carbon emissions. Arguably the most high-profile example is the Guangdong Emissions Trading Scheme (ETS), which was launched in 2013 as a national pilot scheme. We construct a synthetic control of Guangdong and analyse 51,076 party-led newspaper reports to …


Toxic Effect Of Fear Of Losing Out On Self-Esteem: A Moderated Mediation Model Of Conformity And Need For Cognitive Closure In Singapore, Sheila Xi Rui Wee, Chi-Ying Cheng, Haelim Choi, Ciping Goh Dec 2022

Toxic Effect Of Fear Of Losing Out On Self-Esteem: A Moderated Mediation Model Of Conformity And Need For Cognitive Closure In Singapore, Sheila Xi Rui Wee, Chi-Ying Cheng, Haelim Choi, Ciping Goh

Research Collection School of Social Sciences

Kiasu (fear of losing out, FoLO) is considered the single most defining adjective that captures Singapore identity, and it is well-observed in other Asian cultures as well. Despite the widespread endorsement of kiasu in Singapore, there is limited empirical research on the theoretical conception of kiasu as a psychological construct. To empirically investigate kiasu, we validated the construct and measurement of the FoLO mindset in Study 1. In Study 2, we hypothesized and found a negative association between FoLO and Singaporeans’ self-esteem, which was mediated by a higher tendency of conformity. In addition, we hypothesized and found that individuals’ need …


When Intelligence Hurts And Ignorance Is Bliss: Global Pandemic As An Evolutionarily Novel Threat To Happiness, Satoshi Kanazawa, Norman P. Li, Jose C. Yong Dec 2022

When Intelligence Hurts And Ignorance Is Bliss: Global Pandemic As An Evolutionarily Novel Threat To Happiness, Satoshi Kanazawa, Norman P. Li, Jose C. Yong

Research Collection School of Social Sciences

Introduction: The savanna theory of happiness posits that it is not only the current consequences of a given situation that affect happiness but also its ancestral consequences, and that the effect of ancestral consequences on happiness is stronger among less intelligent individuals. But what about situations that did not exist in the ancestral environment and thus have no ancestral consequences? Global pandemic is one such situation that has no ancestral analog, and the theory predicts such evolutionarily novel threats to have a negative effect disproportionately on the life satisfaction of more intelligent individuals.Methods: We analyzed prospectively longitudinal data from population …


Dispositional Gratitude, Health-Related Factors, And Lipid Profiles In Midlife: A Biomarker Study, Andree Hartanto, Nadyanna M. Majeed, Verity Y. Q. Lua, Joax Wong, Nicole R.Y. Chen Dec 2022

Dispositional Gratitude, Health-Related Factors, And Lipid Profiles In Midlife: A Biomarker Study, Andree Hartanto, Nadyanna M. Majeed, Verity Y. Q. Lua, Joax Wong, Nicole R.Y. Chen

Research Collection School of Social Sciences

Dispositional gratitude has emerged in the literature to be associated with many health benefits in measures ranging from self-reported health to biomarkers of cardiovascular risk. However, little is known about the link between dispositional gratitude and lipid profiles. Drawing from the Gratitude and Self-improvement Model that grateful individuals are more likely to strive for actual self-improvement such as engaging in healthy lifestyles, we investigated the relation between dispositional gratitude and serum lipid levels. Participants consisted of 1800 adults from the National Survey of Midlife Development in the United States (MIDUS) 2: Biomarker Project (N= 1054) and MIDUS Refresher: Biomarker Project …


The Effect Of Executive Function On The Development Of Chronic Pain: A Prospective Longitudinal Study, Wee Qin Ng, Andree Hartanto Dec 2022

The Effect Of Executive Function On The Development Of Chronic Pain: A Prospective Longitudinal Study, Wee Qin Ng, Andree Hartanto

Research Collection School of Social Sciences

Increasing evidence suggests a close association between chronic pain and executive function, a set of cognitive processes necessary for goal-directed behaviors. However, there is a dearth of longitudinal studies examining the predictive effect of executive function on the development of chronic pain. Drawing on the cyclical model of executive function and health, we sought to examine how executive function, measured at baseline, may predict chronic pain etiology approximately 9 years later. Using a large-scale dataset of midlife adults (N = 1553) from the MIDUS 2 and 3 (Midlife Development in the United States) studies, we employed multivariate logistic regression to …


From Guo To Tianxia: Linking Two Daoist Theories Of International Relations, Devin K. Joshi Dec 2022

From Guo To Tianxia: Linking Two Daoist Theories Of International Relations, Devin K. Joshi

Research Collection School of Social Sciences

This study examines the international relations theory (IRT) of Daoism, one of Asia’s long-standing traditions to have theorized international politics. Drawing upon Laozi’s Dao De Jing, this study elucidates two Daoist IR theories. First, Laozi provides a state-focused guo-based IRT for conducting foreign policy and managing inter-state relations with emphasis on yielding and softness to overcome violence and domination. Second, Laozi offers a Utopian and globalist tianxia-centered IRT based on following the Dao whereby inter-state rivalry is dissolved in favor of peaceful planetary governance in harmony with the natural rhythms of the cosmos. Whereas previous scholarship often concentrates on only …


Enhancing Literacy Education With Narrative Richness In The Metaverse, Fiona Fui-Hoon Nah, Daniel Jiandong Shen, Umawathy Techanamurthy Dec 2022

Enhancing Literacy Education With Narrative Richness In The Metaverse, Fiona Fui-Hoon Nah, Daniel Jiandong Shen, Umawathy Techanamurthy

Research Collection School Of Computing and Information Systems

Through an education-centric metaverse learning application, this research aims to assess the use of narrative richness to deliver media, language, and sustainability literacy education. The 21st-century learning needs require teaching and learning resources to be shared and managed more effectively across institutions. The use of metaverse features can help to manage varying narrative richness to boost learning reflection and attitude. Despite its potential, it is unclear how narrative richness in the metaverse can enhance teaching and learning. The study proposed in this research, which includes institutions from four Asian countries, is driven by this knowledge and evidence gap. Module leaders …


Nutritional Status, Health Risk Behaviors, And Eating Habits Are Correlated With Physical Activity And Exercise Of Brazilian Older Hypertensive Adults: A Cross-Sectional Study, Leonardo Santos Lopes Da Silva, Daniel De Freitas Batalhão, Anderson Dos Santos Carvalho, Lucimere Bohn, Nilo César Ramos, Pedro Pugliesi Abdalla Dec 2022

Nutritional Status, Health Risk Behaviors, And Eating Habits Are Correlated With Physical Activity And Exercise Of Brazilian Older Hypertensive Adults: A Cross-Sectional Study, Leonardo Santos Lopes Da Silva, Daniel De Freitas Batalhão, Anderson Dos Santos Carvalho, Lucimere Bohn, Nilo César Ramos, Pedro Pugliesi Abdalla

Teacher Education

Background: Nutritional status, health risk behaviors, eating habits, and other comorbidities (such as diabetes) may be associated with recommended amounts of physical activity (PA) and exercise (EX) in healthy older adults. However, these associations are still unclear for older hypertensive adults, who require greater care from health professionals. The purpose of this study was to associate the nutritional status, health risk behaviors, eating habits, and the presence of diabetes with recommended amounts of physical activity and exercise practice of older hypertensive adults. Methods: Ten thousand seven hundred eighty-nine older hypertensive adults (70.9 ± 7.4 years) from the VIGITEL telephone survey …


The Impact Of Global Health Disparities On Atopic Dermatitis In Displaced Populations: Narrowing The Health Equity Gap For Patients With Skin Of Color., Sami Jelousi, Divya Sharma, Andrew Alexis, Jenny E Murase Dec 2022

The Impact Of Global Health Disparities On Atopic Dermatitis In Displaced Populations: Narrowing The Health Equity Gap For Patients With Skin Of Color., Sami Jelousi, Divya Sharma, Andrew Alexis, Jenny E Murase

Ambulatory and Primary Care Articles

Atopic dermatitis (AD) is a relatively common inflammatory skin disease marked by eczematous lesions and pruritus often leading to significant morbidity and quality of life impairment for those affected. Recent studies have shown that patients with skin of color (SOC) carry a larger disease burden than patients of European descent. In the USA, these disparities are partly due to structural, environmental, and interpersonal racism. From a global perspective, there is a paucity of research on the burden of atopic dermatitis and other inflammatory skin diseases experienced by the record numbers of refugees, migrants, and asylum seekers around the world. Although …


Study Protocol Cover-All: Clinical Impact Of A Volumetric Image Method For Confirming Tumour Coverage With Ablation On Patients With Malignant Liver Lesions, Yuan-Mao Lin, Iwan Paolucci, Brian M Anderson, Caleb S O'Connor, Bastien Rigaud, Maria Briones-Dimayuga, Kyle A Jones, Kristy K Brock, Bryan M Fellman, Bruno C Odisio Dec 2022

Study Protocol Cover-All: Clinical Impact Of A Volumetric Image Method For Confirming Tumour Coverage With Ablation On Patients With Malignant Liver Lesions, Yuan-Mao Lin, Iwan Paolucci, Brian M Anderson, Caleb S O'Connor, Bastien Rigaud, Maria Briones-Dimayuga, Kyle A Jones, Kristy K Brock, Bryan M Fellman, Bruno C Odisio

Faculty, Staff and Student Publications

Purpose: This study aims to evaluate the intra-procedural use of a novel ablation confirmation (AC) method, consisting of biomechanical deformable image registration incorporating AI-based auto-segmentation, and its impact on tumor coverage by quantitative three-dimensional minimal ablative margin (MAM) CT-generated assessment.

Materials and methods: This single-center, randomized, phase II, intent-to-treat trial is enrolling 100 subjects with primary and secondary liver tumors (≤ 3 tumors, 1-5 cm in diameter) undergoing microwave or radiofrequency ablation with a goal of achieving ≥ 5 mm MAM. For the experimental arm, the proposed novel AC method is utilized for ablation applicator(s) placement verification and MAM assessment. …


Hpv-Associated Anal Cancer Knowledge, Attitudes, And Health Communication Behaviors Among Non-Clinical Providers At Hiv/Aids Service Organizations In Southern United States Region, Olufunto A Olusanya, Aditi Tomar, Jonathan Thomas, Praisy Johnson, Lisa T Wigfall Dec 2022

Hpv-Associated Anal Cancer Knowledge, Attitudes, And Health Communication Behaviors Among Non-Clinical Providers At Hiv/Aids Service Organizations In Southern United States Region, Olufunto A Olusanya, Aditi Tomar, Jonathan Thomas, Praisy Johnson, Lisa T Wigfall

Faculty, Staff and Student Publications

Co-infection with HIV/HPV and bio-behavioral risk factors (e.g., immunodeficiency, un-protected sex) increase likelihood for developing anal and other HPV-associated cancers among people living with HIV/AIDS (PLWHA). We explored knowledge, attitudes, and health communication regarding HPV-associated anal cancers among HIV/AIDS service organization (ASO) employees/volunteers delivering non-clinical services to PLWHA. Participants (n=59) were recruited from six ASOs located in the South United States Census region and completed a 118-item self-administered survey. For current analyses, outcome measures were knowledge, attitudes, and health communication regarding anal cancer. Descriptive statistics assessed outcome measures which were subsequently dichotomized into binary variables (i.e., high/favorable or low/unfavorable). Fisher's …


Remittance: A New Instrument For Change -- Understanding The Impact Of Remittances On Home Countries Development, Alex M. Hamed Dec 2022

Remittance: A New Instrument For Change -- Understanding The Impact Of Remittances On Home Countries Development, Alex M. Hamed

Graduate Program in International Studies Theses & Dissertations

This dissertation constructs a framework to investigate the impact of remittances on the recipient countries in the context of the Middle East and North Africa (MENA) and the European Union (EU). The framework will explore the effects of labor migration induced by bilateral labor agreements (BLAs). Such labor agreements are guided by the desire of autocratic governments to utilize their citizens to finance social contracts to sustain the authoritarian systems. The labor movements are further enhanced by accumulating social capital and remittances. The research also highlights the impact of remittances on the home country's institutional quality. It also highlights the …


Bcl11b And Atoh8 Coordinate Cellular Plasticity For Reprogramming And Transformation, Mo-Fan Huang, Rachel Shoemaker, Dung-Fang Lee Dec 2022

Bcl11b And Atoh8 Coordinate Cellular Plasticity For Reprogramming And Transformation, Mo-Fan Huang, Rachel Shoemaker, Dung-Fang Lee

Faculty, Staff and Student Publications

By dissecting and comparing the transcriptional trajectories and epigenomic traits of reprogramming and transforming cells at the single-cell resolution, Huyghe et al discovered Bcl11b and Atoh8, two key transcription factors controlling cell plasticity during pluripotent reprogramming and oncogenic transformation.


Prognostic Impact Of Breslow Thickness In Acral Melanoma: A Retrospective Analysis, Xiaoting Wei, Yu Chen, Hong Yao, Di Wu, Hang Li, Rui Zhang, Zhihong Chi, Chuanliang Cui, Xue Bai, Lili Mao, Zhonghui Qi, Ke Li, Shijie Lan, Lizhu Chen, Rui Guo, Xinyu Yao, Bin Lian, Yan Kong, Jie Dai, Bixia Tang, Xuan Wang, Jeffrey E Gershenwald, Charles M Balch, Jun Guo, Lu Si Dec 2022

Prognostic Impact Of Breslow Thickness In Acral Melanoma: A Retrospective Analysis, Xiaoting Wei, Yu Chen, Hong Yao, Di Wu, Hang Li, Rui Zhang, Zhihong Chi, Chuanliang Cui, Xue Bai, Lili Mao, Zhonghui Qi, Ke Li, Shijie Lan, Lizhu Chen, Rui Guo, Xinyu Yao, Bin Lian, Yan Kong, Jie Dai, Bixia Tang, Xuan Wang, Jeffrey E Gershenwald, Charles M Balch, Jun Guo, Lu Si

Faculty, Staff and Student Publications

Background: Evidence for the prognostic importance of tumor thickness in acral melanoma (AM) patients is limited.

Objective: The objective of the study was to determine the prognostic impact of Breslow thickness in AM.

Methods: This multicenter study enrolled patients diagnosed with localized AM between January 1, 2000 and December 31, 2017. Melanoma-specific survival (MSS) in different tumor thickness strata (T1-T4: ≤1, >1-2, >2-4, >4 mm, respectively) was estimated by the Kaplan-Meier method. Comparisons were performed by the log-rank test and multivariable Cox regression.

Results: A total of 853 patients with clinical N0 (cN0) AM were included in the analysis. The …


Factors Modulating 99mtc-Maa Planar Lung Dosimetry For 90y Radioembolization, Benjamin P Lopez, Armeen Mahvash, James P Long, Marnix G E H Lam, S Cheenu Kappadath Dec 2022

Factors Modulating 99mtc-Maa Planar Lung Dosimetry For 90y Radioembolization, Benjamin P Lopez, Armeen Mahvash, James P Long, Marnix G E H Lam, S Cheenu Kappadath

Faculty, Staff and Student Publications

Purpose: To investigate the accuracy and biases of predicted lung shunt fraction (LSF) and lung dose (LD) calculations via 99m Tc-macro-aggregated albumin (99m Tc-MAA) planar imaging for treatment planning of 90 Y-microsphere radioembolization.

Methods and materials: LSFs in 52 planning and LDs in 44 treatment procedures were retrospectively calculated, in consecutive radioembolization patients over a 2 year interval, using 99m Tc-MAA planar and SPECT/CT imaging. For each procedure, multiple planar LSFs and LDs were calculated using different: (1) contours, (2) views, (3) liver 99m Tc-MAA shine-through compensations, and (4) lung mass estimations. The accuracy of each planar-based LSF and LD …


Bayesian Hierarchical Random-Effects Meta-Analysis And Design Of Phase I Clinical Trials, Ruitao Lin, Haolun Shi, Guosheng Yin, Peter F Thall, Ying Yuan, Christopher R Flowers Dec 2022

Bayesian Hierarchical Random-Effects Meta-Analysis And Design Of Phase I Clinical Trials, Ruitao Lin, Haolun Shi, Guosheng Yin, Peter F Thall, Ying Yuan, Christopher R Flowers

Faculty, Staff and Student Publications

We propose a curve-free random-effects meta-analysis approach to combining data from multiple phase I clinical trials to identify an optimal dose. Our method accounts for between-study heterogeneity that may stem from different study designs, patient populations, or tumor types. We also develop a meta-analytic-predictive (MAP) method based on a power prior that incorporates data from multiple historical studies into the design and conduct of a new phase I trial. Performances of the proposed methods for data analysis and trial design are evaluated by extensive simulation studies. The proposed random-effects meta-analysis method provides more reliable dose selection than comparators that rely …


Identity-Related Experiences Of Asian American Trainees In Gynecologic Oncology, Jhalak Dholakia, Yeon Woo Lee, Karen H Lu, Warner K Huh, S Diane Yamada, Katherine C Fuh, Amanika S Kumar, Margaret I Liang, Navya Nair, Kenneth H Kim Dec 2022

Identity-Related Experiences Of Asian American Trainees In Gynecologic Oncology, Jhalak Dholakia, Yeon Woo Lee, Karen H Lu, Warner K Huh, S Diane Yamada, Katherine C Fuh, Amanika S Kumar, Margaret I Liang, Navya Nair, Kenneth H Kim

Faculty, Staff and Student Publications

Background: Anti-Asian violence increased during the COVID-19 pandemic. Asian American/Pacific Islanders (AAPI) represent a diverse population experiencing a long history of stereotyping and exclusionism; however, this group is often left out of diversity/inclusion conversations. In academic medicine, AAPI are under-represented in leadership. We characterized the personal/professional experiences of AAPI gynecologic oncology trainees and assessed the impact of a virtual panel discussion with leaders in the field.

Methods: An anonymous survey was disseminated online to trainees in/interested in gynecologic oncology fellowship who identified as AAPI, using modified snowball sampling. A virtual session with AAPI leaders in gynecologic oncology discussed themes emerging …


Impact Of A Dedicated Atrial Fibrillation Clinic On Diagnosis-To-Ablation Time., Andrea Robinson, Nagesh Chopra, Auroa G Badin, Sreedhar R Billakanty, Keaira Cooper, Eugene Y Fu, Jennifer James, Victoria Murnane, Jill Swinning, Mitchell Stelzer, Jaret D Tyler, Anish K Amin Dec 2022

Impact Of A Dedicated Atrial Fibrillation Clinic On Diagnosis-To-Ablation Time., Andrea Robinson, Nagesh Chopra, Auroa G Badin, Sreedhar R Billakanty, Keaira Cooper, Eugene Y Fu, Jennifer James, Victoria Murnane, Jill Swinning, Mitchell Stelzer, Jaret D Tyler, Anish K Amin

Heart and Vascular Articles

BACKGROUND: Outcomes following catheter ablation (CA) for atrial fibrillation (AF) improve as the diagnosis-to-ablation time (DAT) shortens. Use of a protocol-based integrated care model through a dedicated atrial fibrillation clinic (AFC) may serve to standardize treatment pathways and decrease DAT.

OBJECTIVE: To evaluate the DAT and clinical characteristics of patients with AF referred from an AFC vs a conventional electrophysiology clinic (EC).

METHODS: Retrospective analysis was completed in consecutive patients undergoing index AF ablation at Riverside Methodist Hospital in 2019 with minimum 1 year follow-up. Patients were categorized based off their CA referral source (AFC vs EC) and where the …


Who Leads The Emergency Department Debrief?, Allison D. Lane, Ethan Bryce, Marcy R. Milbrandt, Lisa R. Stoneking Dec 2022

Who Leads The Emergency Department Debrief?, Allison D. Lane, Ethan Bryce, Marcy R. Milbrandt, Lisa R. Stoneking

Journal of Wellness

No abstract provided.


Mdm2 Antagonist Improves Therapeutic Activity Of Azacitidine In Myelodysplastic Syndromes And Chronic Myelomonocytic Leukemia, Yue Wei, Hong Zheng, Pamela Pennington Lockyer, Faezeh Darbaniyan, Ziyi Li, Rashmi Kanagal-Shamanna, Kelly A Soltysiak, Hui Yang, Irene Ganan-Gomez, Guillermo Montalban-Bravo, Kelly S Chien, Kim-Anh Do, Naval Daver, Guillermo Garcia-Manero Dec 2022

Mdm2 Antagonist Improves Therapeutic Activity Of Azacitidine In Myelodysplastic Syndromes And Chronic Myelomonocytic Leukemia, Yue Wei, Hong Zheng, Pamela Pennington Lockyer, Faezeh Darbaniyan, Ziyi Li, Rashmi Kanagal-Shamanna, Kelly A Soltysiak, Hui Yang, Irene Ganan-Gomez, Guillermo Montalban-Bravo, Kelly S Chien, Kim-Anh Do, Naval Daver, Guillermo Garcia-Manero

Faculty, Staff and Student Publications

Failure of hypomethylation agent (HMA) treatments is an important issue in myelodysplastic syndromes (MDS) and chronic myelomonocytic leukemia (CMML). Recent studies indicated that function of wildtype TP53 positively impacts outcome of HMA treatments. We investigated the combination of the HMA azacitidine (AZA) with DS-3032b and DS-5272, novel antagonists of the TP53 negative regulator MDM2, in cellular and animal models of MDS and CMML. In TP53 wildtype myeloid cell line, combinational effects of DS-3032b or DS-5272 with AZA were observed. In Tet2-knockout mouse model of MDS and CMML, DS-5272 and AZA combination ameliorated disease-like phenotype. RNA-Seq analysis in mouse bone …


Consensus Subtypes Of Hepatocellular Carcinoma Associated With Clinical Outcomes And Genomic Phenotypes, Sung Hwan Lee, Sun Young Yim, Yun Seong Jeong, Qi-Xiang Li, Sang-Hee Kang, Bo Hwa Sohn, Shwetha V Kumar, Ji-Hyun Shin, You Rhee Choi, Jae-Jun Shim, Hayeon Kim, Ji Hoon Kim, Shin Kim, Sheng Guo, Randy L Johnson, Ahmed Kaseb, Koo Jeong Kang, Yun Shin Chun, Hee Jin Jang, Byoung Gill Lee, Hyun Goo Woo, Min Jin Ha, Rehan Akbani, Lewis R Roberts, David A Wheeler, Ju-Seog Lee Dec 2022

Consensus Subtypes Of Hepatocellular Carcinoma Associated With Clinical Outcomes And Genomic Phenotypes, Sung Hwan Lee, Sun Young Yim, Yun Seong Jeong, Qi-Xiang Li, Sang-Hee Kang, Bo Hwa Sohn, Shwetha V Kumar, Ji-Hyun Shin, You Rhee Choi, Jae-Jun Shim, Hayeon Kim, Ji Hoon Kim, Shin Kim, Sheng Guo, Randy L Johnson, Ahmed Kaseb, Koo Jeong Kang, Yun Shin Chun, Hee Jin Jang, Byoung Gill Lee, Hyun Goo Woo, Min Jin Ha, Rehan Akbani, Lewis R Roberts, David A Wheeler, Ju-Seog Lee

Faculty, Staff and Student Publications

BACKGROUND AND AIMS: Although many studies revealed transcriptomic subtypes of HCC, concordance of the subtypes are not fully examined. We aim to examine a consensus of transcriptomic subtypes and correlate them with clinical outcomes.

APPROACH AND RESULTS: By integrating 16 previously established genomic signatures for HCC subtypes, we identified five clinically and molecularly distinct consensus subtypes. STM (STeM) is characterized by high stem cell features, vascular invasion, and poor prognosis. CIN (Chromosomal INstability) has moderate stem cell features, but high genomic instability and low immune activity. IMH (IMmune High) is characterized by high immune activity. BCM (Beta-Catenin with high Male …


Allergic Sensitization Pattern In The Korean Dermatologic Patients, Yujin Han, Yu Ri Woo, Hei Sung Kim, Jeong Deuk Lee, Sookhee Choi, Jeesuk Yu, Sang Hyun Cho Dec 2022

Allergic Sensitization Pattern In The Korean Dermatologic Patients, Yujin Han, Yu Ri Woo, Hei Sung Kim, Jeong Deuk Lee, Sookhee Choi, Jeesuk Yu, Sang Hyun Cho

Faculty, Staff and Student Publications

BACKGROUND: Avoiding causative allergens is important for controlling the clinical course of allergic diseases. Allergen sensitization is influenced by many factors including the environment and lifestyle. The socioeconomic development, climate, and lifestyle changes have increased the prevalence of allergic diseases worldwide. However, there is little information about changes in the trend of the common allergens over time.

OBJECTIVE: This study was aimed at identifying the trends of the common allergens in Korea over a 10-year period based on the results of the multiple allergosorbent test chemiluminescent assay (MAST-CLA).

METHODS: We retrospectively reviewed the medical records of 5,760 patients aged ≥18 …


Massive Macroglossia, A Rare Side Effect Of Covid-19: Clinical, Histologic, And Genomic Findings In Covid-19-Positive Versus Covid-19-Negative Patients, Victoria A Mañón, David Chubb, Laura S Farach, Rachid Karam, Mary C Farach-Carson, Nadarajah Vigneswaran, Karan Saluja, Simon Young, Mark Wong, James C Melville Dec 2022

Massive Macroglossia, A Rare Side Effect Of Covid-19: Clinical, Histologic, And Genomic Findings In Covid-19-Positive Versus Covid-19-Negative Patients, Victoria A Mañón, David Chubb, Laura S Farach, Rachid Karam, Mary C Farach-Carson, Nadarajah Vigneswaran, Karan Saluja, Simon Young, Mark Wong, James C Melville

Faculty, Staff and Student Publications

PURPOSE: The primary purpose of this study is to identify if there is an underlying genetic predisposition for COVID-related macroglossia and if this susceptibility is higher among individuals of African heritage. Secondary objectives include determining if genetic testing of COVID-infected patients who are intubated and prone could identify patients with higher susceptibility to the development of macroglossia.

METHODS: A retrospective chart review was completed for each patient, and prospectively, genetic and histopathologic analyses were completed. Whole-exome sequencing was completed on two patients; immunohistochemistry was completed on the COVID-positive tissue samples.

RESULTS: Histopathology of the COVID-positive patient revealed significant peri-lymphocytic infiltrate, …


Understanding The Impact Of Covid-19 Pandemic On Teleworkers' Experiences Of Perceived Threat And Professional Isolation: The Moderating Role Of Friendship, Xinyu (Judy) Hu, Mahesh Subramony Dec 2022

Understanding The Impact Of Covid-19 Pandemic On Teleworkers' Experiences Of Perceived Threat And Professional Isolation: The Moderating Role Of Friendship, Xinyu (Judy) Hu, Mahesh Subramony

Arts & Sciences Faculty Publications

Drawing from conservation of resource theory and the social support resource theory, this study examines how the severity of an exogenous disruptive event – the COVID-19 pandemic – in one's community influences teleworkers' well-being outcomes indirectly through their perceptions of pandemic-related threat and experience of professional isolation, as well as the buffering effect of friendship on these relationships. Utilizing time-lagged data from participants of a two-wave survey panel (N = 351) and objective data of COVID-19 severity from counties around the United States, we found that perceived threat, but not professional isolation, mediated the negative effect of proportion of confirmed …


Multidisciplinary Simulation Of Trauma In Pregnancy With Resuscitative Endovascular Balloon Occlusion Of The Aorta (Reboa) Utilization., Peter Hopmann, Jaya Sai Varre, Gary Duncan, William B Devoe, Brad D Gable Dec 2022

Multidisciplinary Simulation Of Trauma In Pregnancy With Resuscitative Endovascular Balloon Occlusion Of The Aorta (Reboa) Utilization., Peter Hopmann, Jaya Sai Varre, Gary Duncan, William B Devoe, Brad D Gable

Trauma and Acute Care Articles

Background Studies have demonstrated the use of resuscitative endovascular balloon occlusion catheters of the aorta (REBOA) in the setting of postpartum hemorrhage and traumatic hemorrhagic shock. However, REBOA is infrequently utilized leading to a lack of clinician comfort. This study's aim was to demonstrate the utility of REBOA in a hemorrhaging pregnant trauma patient and improve clinician comfort with the placement of REBOA while emphasizing collaboration between medical specialties. Methods A multidisciplinary in-situ simulation was developed for the management of a pregnant patient with an abdominal gunshot wound evaluated by obstetrics and surgery teams. A trauma survey, emergency c-section, massive …