Digital Commons Network^™

Effects Of Roundup Exposure On Redox Status, Cellular Apoptosis, And Antioxidant And Osmoregulatory Enzyme Expressions In Goldfish (Carassius Auratus), Md Imran Noor

Theses and Dissertations

Intense anthropogenic activities of industrialized nations dramatically increase environmental pollution. This study focused on the effects of Roundup, a glyphosate-based herbicide, exposure (low- and high-dose: 0.5 and 5 mg/L for 2 weeks) on dinitrophenyl protein (DNP), nitrotyrosine protein (NTP), superoxidase dismutase (SOD), catalase (CAT), Na+ /K+ - ATPase (NKA), and renin expressions, and cellular apoptosis in the gills and kidneys of goldfish. Histopathological analysis showed widespread tissue damage in both gills and kidneys. Immunohistochemical analysis provided insights into the expression of molecular biomarkers in tissues. Fish exposed to Roundup exhibited a significant (P<0.05) upregulation in DNP, NTP, SOD, and CAT expressions, and apoptotic nuclei in both tissues. Additionally, exposure to Roundup significantly increased renin expression in kidneys and decreased NKA expression in gills. Overall, our results suggest that exposure to Roundup induces oxidative/nitrative stress and cellular apoptosis and alters osmoregulatory and antioxidant systems which may lead to impaired physiological functions in goldfish.

Growing Up Butchona On The Texas-Mexico Border A Marimacha Memoir, Julietta Rivera

Theses and Dissertations

Growing Up Butchona on the Border is a queer, Latina memoir that takes place on the Texas-Mexico border. This thesis is a journey in words and pictures that spans throughout an immigration crisis, a worldwide pandemic and the fallout that follows a world-wide lockdown; eventually leading down the rocky road to self-discovery. The thesis opens with a fictional account of Torita Torcida, a seven-year-old Honduran immigrant that makes her way across the Texas-Mexico border with her mother only to be ripped away from her when the truck they were smuggled in is seized by border patrol. Images and words come …

Incorporating Native Plants In Insectary Strips To Promote Insect Diversity And Below-Ground Beneficial Microbes In South Texas, Lindsey N. Richards

Theses and Dissertations

Farm edges are generally the most undisturbed areas in a farm with diverse vegetation and can enhance agrobiodiversity and provide crucial food and shelter for wildlife, insects, and soil biota. Planting native wildflowers with the ability to reseed and withstand local climatic conditions for semi-permanent vegetation around farm edges or in between crops has potential to biologically control pests. To test this, we ran a two-year study and installed three different flowering insectary strips on a certified organic vegetable farm in South Texas during the winter season. The treatments were: 1) a commercially sourced 17-species native wildflower seed mix; 2) …

Influence Of Glucose And Lactic Acid On Macrophage Transition In Pancreatic Tumors, Anyssa A. Rodriguez

Theses and Dissertations

Pancreatic cancer is the seventh leading cause of cancer-related mortality worldwide. According to the American Cancer Society, it is the eleventh most common cancer diagnosed in both men and women in the United States. Pancreatic ductal adenocarcinoma (PDAC) comprises 90% of all pancreatic malignancies and is associated with poor clinical outcome because of late diagnosis and resistance to therapy. In addition, studies show that the tumor microenvironment has become an emerging interest in cancer research due to its complex components and unique characteristics that aid in cancer initiation, maintenance, and progression. Accumulating evidence signifies that tumor associated macrophages (TAMs) play …

Weather Parameters Influencing The Incidence Of Citrus Canker Caused By Aw Strain In The Rio Grande Valley, Amit Sharma

Theses and Dissertations

Citrus canker caused by bacterium Xanthomonas citri subsp. citri (Xcc) seriously affects the citrus industry by making the fruit unmarketable due to unsightly lesions on the fruit. Canker caused by Aw strain of Xcc was reported in the citrus trees located in the residential areas of the Rio Grande Valley (RGV). Canker severity differs amongst cultivars/varieties, and it is influenced by prevailing environmental conditions. Multiple regression modeling of the disease incidence with the environmental variables such as temperature, humidity, windspeed, wind gust, and rainfall was performed to understand the environmental conditions that are favorable for spread of citrus …

Numerical Simulation Of Vibration - Based Piezoelectric Energy Harvester For Shape Comparison, Adriana Rosas

Theses and Dissertations

This work investigates the shape optimization of piezoelectric energy harvesters subjected to mechanical vibration using ABAQUS/Standard software. Three piezoelectric energy harvesters with different dimensions but the same areas were created to identify if model dimensions have an impact on the output voltage. The models were tested at different speeds to create an output voltage. Once the output voltages were obtained, the results were compared with each other to find if shape optimization on piezoelectric energy harvesters has an impact on scavenging energy from mechanical vibrations.

Water Hardness Removal By Electrochemical Precipitation In A Continuous Flow Condition Using Conductive Concrete As Cathode, Tahsin Tareque

Theses and Dissertations

This study focuses on the electrochemical precipitation (EP) process to reduce excess water hardness from the Lower Rio Grande Valley (LRGV) tap water using electrically conductive concrete as cathode in a continuous flow condition. LRGV tap water is extremely hard with hardness more than 350 mg/L as CaCO3. Humans can pleasantly consume water with hardness less than 150 mg/l as CaCO3 according to World Health Organization (WHO). Hard water is also known to cause mechanical problems to boilers and heat exchangers. In this process, electricity is passed through electrodes submerged in electrolyte, which causes an alkaline environment around the cathode …

Feasibility Analysis Of Embedding Optical Fiber Sensor Into Additively Manufactured Part, Mahmudul Hasan Porag

Theses and Dissertations

The research tried to examine the viability of the embedment of optical fiber sensors in Additively built components, packaging the sensors within the components, and characterizing the sensors for sensing a specified measurement. Optical fiber sensors are popular due to their small size, resilience against electromagnetic radiation, and reliability in potentially dangerous conditions. Embedding fibers inside a product allows for the monitoring of critical areas, allowing for preemptive action in the case of a breakdown. Coupons of Inconel 718 were made using laser powder-bed fusion (LPBF), with the fabrication settings tuned to determine whether such a development was possible. After …

Physician Quality Scores And The Presentation And Delivery Method Of Data In A Residency Program, Monaco Briggs

Electronic Theses and Dissertations

The United States health care expenditures are higher than any other developed country. Due to this, physician payment reform is moving from fee-for-service (FFS) to a value-based model, with a focus on prevention and quality. The purpose of this quantitative study was to measure the effect of a series of data delivery interventions associated with the quality scorecards and which method increased the quality scores at a medical teaching practice in Tennessee.

Data were gathered via the Physician Quality Scorecard, an internally developed instrument. Each quarter, a different data delivery intervention was performed, and scorecard data were analyzed …

Validating An Internet Gaming Disorder Measure During Covid-19: Video Game Use, Distance Learning, And Impacts Of Covid-19 On Gaming Behavior, Christin Collie

Electronic Theses and Dissertations

For most students, playing video games is a popular, enjoyable activity to do in their leisure time. While many people play video games for fun, some do develop problems associated with their play. Excessive engagement in video game play can lead to significant impairment and clinically significant levels of harm. However, there are several important gaps in the research literature which limit understanding of potential harm. First, little is known about the gaming behavior of students, ranging from middle-school to graduate school, specifically as it relates to their reasons for playing video games and their time spent playing. Second, concerns …

An Evaluation Of Media Messaging By African Fashion Designers And Marketing Message Strategies, Esther Oyindamola Oyanibi

Electronic Theses and Dissertations

In recent times, African brands have been featured heavily in global landscape fashion events, with brands from Nigeria, South Africa, and Kenya leading the way. Although such recognition could be traced to their expertise, the unique approach of African brands involves putting out unique designs that easily stand out in the global fashion market. However, their uniqueness goes beyond the designs they put out, as it is also strongly expressed in their media messaging and, consequentially, their marketing strategy.

This study provides a content analysis of the most important characteristics of eight brands from different regions of the African continent. …

“It’S About The Two Selves”: Experiences In Code-Switching Between Home And Academic Environments, Travis Wolven

Electronic Theses and Dissertations

This qualitative research study is an exploration of how college students navigate code-switching between their home and academic environments. Data were collected from five participants using interview and small group methods. Through the lenses of Coordinated Management of Meaning (CMM) and Memorable Messages (MM) frameworks, the researcher explores how key MMs affect how participants coordinate and manage meaning in communications with others in their home and college environments. Findings were fourfold: 1) participants chose between following established and creating new rules when code-switching; 2) participants shared experiences and strategies regarding knowing when and how to code-switch; 3) preparing audiences for …

A Frayed Edge: A Qualitative And Poetic Inquiry Analysis Of White Antiracist Protest In 2020, Emily Katt

Electronic Theses and Dissertations

This multiphasic study explored the narratives of five first-time Black Lives Matter protesters demonstrating during the historic confluence of conflicts in 2020 America. After positioning the liminal 2020 circumstances within an antiracist research lens, the author analyzed, first through grounded theory and then secondarily through poetic inquiry, how these five participants described their protest experiences. The grounded theory phase yielded an overarching theory that first-time protestors experienced a dual process of unsuturing and of calling-out, with three subthemes categorized within each of these two processes. The author moved into analysis with the poetic inquiry phase, crafting poems guided by six …

Folic Acid – Carbon Dots – Doxorubicin Nanoparticles As Cancer Theranostic, Michael Tetteh

Electronic Theses and Dissertations

This work focused on engineering bi-functionalized nanoparticles (NPs) based on carbon dots (CDs) to improve early cancer detection and treatment. Therefore, using folic acid (FA) as a targeting agent, the CDs were prepared to deliver high concentrations (HC) of doxorubicin (DOX) and gemcitabine (GEM) covalently and non-covalently to cancer cells. The prepared FA-CDs-DOX/GEM-HC NPs were characterized using ultraviolet-visible spectroscopy, fluorescence spectroscopy, and Fourier transform infrared spectroscopy. Assessment of the drug loading capacity (DLC) and drug loading efficiency (DLE) indicated that the non-covalent NPs have low DLC but high DLE compared to the relatively low DLE and high DLC of covalent …

Integrating Model-Based Systems Engineering Industry Transformations For Workforce Development, Wilma Analisa Ankobiah

Theses and Dissertations

This study explores whether MBSE industry workforce requirements are being satisfied by the academic curricula of US institutions. Using an industry survey, which is highlighted in Chapter 3, identifies the existing perception of MBSE from various industries and explores the MBSE needs of professionals, such as tools concepts and languages. It examines how industry professionals perceive MBSE, the advantages and challenges of MBSE use and the preferred MBSE tools, languages and knowledge of concepts deemed necessary to ensure project success in the respective industry sectors. Results of phase 1 industry survey will summarize the current MBSE concepts, tools and languages …

The Romantic Style In The Piano Works Of Manuel M. Ponce, Oscar Vazquez Medrano

Glenn Korff School of Music: Dissertations, Theses, Student Creative Work, and Performances

Manuel M. Ponce is one of the most recognized Mexican composers of the twentieth century. He is known for his contributions to the guitar and piano literature, but more importantly, for his efforts to introduce musical nationalism in a world where Romantic opera and salon music dominated Mexico’s music scene.

This document has an introduction, six chapters, a conclusion, a bibliography, and three appendixes. The introduction includes pertinent background on Ponce’s music and the types of research dedicated to him, as well as the stylistic division of his music by Ponce scholars.

Chapter one explains the historical context in Mexico …

Measuring Macroeconomic Shocks Of The Covid-19 Pandemic: An Empirical Analysis For Bhutan, Lekey Dorji

Theses

Taking GDP growth and inflation as endogenous variables, this paper employs a Structural VAR from Baumeister and Hamilton (2015, 2019) to identify aggregate demand and aggregate supply shocks for Bhutan, focusing on the COVID-19 pandemic. The results suggest that 94 percent of the GDP growth plunge in 2020 is attributable to a fall in aggregate supply. The higher inflation during the COVID-19 pandemic in 2020 also implies a negative supply shock. Although the magnitudes differ, characterizing the COVID-19 pandemic in Bhutan as a supply shock coincides with preceding episodes that were also primarily driven by supply shocks.

Abusing Discretion: The Battle For Childhood In Schools, Hannah Dodson

Michigan Journal of Race and Law

For too many children the schoolhouse doors become a point of entry into the criminal justice system. Children of color are the most likely to suffer from this phenomenon. The presence of policing in schools is a key contributor to this “school-to-prison pipeline.” This Note argues that broad, discretionary mandates for school resource officers (SROs) promote biased law enforcement that impacts Black girls in different and specific ways. I contend that SRO mandates can be effectively limited by strategically bolstering community organizing efforts with impact litigation.

Carceral Intent, Danielle C. Jefferis

Michigan Journal of Race and Law

For decades, scholars across disciplines have examined the stark injustice of American carceralism. Among that body of work are analyses of the various intent requirements embedded in the constitutional doctrine that governs the state’s power to incarcerate. These intent requirements include the “deliberate indifference” standard of the Eighth Amendment, which regulates prison conditions, and the “punitive intent” standard of due process jurisprudence, which regulates the scope of confinement.

This Article coins the term “carceral intent” to refer collectively to those legal intent requirements and examines critically the role of carceral intent in shaping and maintaining the deep-rooted structural racism and …

The Effect Of Tharthar-Tigris Canal On The Environmental Properties Of The Tigris River Northern Baghdad, Iraq, Osama S. Majeed, Ahmed J. M. Al-Azawi, Muhanned R. Nashaat

Baghdad Science Journal

The present study is considered the first on this sector of the Tigris River after 2003. It is designed for two aims, the first is to demonstrate the seasonal variations in physicochemical parameters of Tharthar-Tigris Canal and Tigris River; the second is to explain the possible effects of canal on some environmental properties in the Tigris River. Water samples were being collected monthly. Six sampling sites were selected, two on Tharthar Canal and four along the Tigris River, one before the confluence as a control site and the others downstream the confluence with the canal. For a period from January …

Determination Of Nickel And Cobalt In Cosmetic Products Marketed In Iraq Using Spectrophotometric And Microfluidic Paper-Based Analytical Device (Μpads) Platform, Ekhlas A. Abdulkareem, Jwan O. Abdulsattar

Baghdad Science Journal

Two quantitative, environment-friendly and easily monitored assays for Ni (II) and Co (III) ions analysis in different lipstick samples collected from 500-Iraqi dinars stores located in Baghdad were introduced. The study was based on the reaction of nickel (II) ions with dimethylglyoxime (DMG) reagent and the reaction of cobalt (III) ions with 1-nitroso-2-naphthol (NN) reagent to produce colored products. The color change was measured by spectrophotometric method at 565 nm and 430 nm for Ni and Co, respectively, with linear calibration graphs in the concentration range 0.25-100 mg L-1 (Ni) and 0.5-100 mg L-1 (Co) and LOD and LOQ of …

Investigation Of The Association Of Agtr1 A1166c Rs5186 And Fto Rs9939609 Polymorphisms With The Obesity In Children And Adolescents, Alaa Hashim Abd Ali, Teplyakova E. D., Bocharova O. V., Karantysh G. V., Shkurat T. P.

Baghdad Science Journal

Obesity is a risk factor for a number of chronic conditions. Obesity is clinically defined using the body mass index (BMI) as weight in kg divided by (height)2 in m2 correlated with obesity. Currently, genetic markers of obesity are being studied. This study focused on the association between the angiotensin II receptor AGTR1 gene (A1166C) and fat mass and obesity-associated protein also known as alpha-ketoglutarate-dependent dioxygenase (FTO) (rs9939609) in obese children and adolescents patients in Rostov region, Russia. Five-hundreds of Russian nationality child and adolescent were recruited for the obesity-control studies. The relationship between the A1166C polymorphism of the AGTR1 …

Characterizing Treatment Resistance In Muscle Invasive Bladder Cancer Using The Chicken Egg Chorioallantoic Membrane Patient-Derived Xenograft Model, Hugo Villanueva, Gabrielle A Wells, Malachi T Miller, Mariana Villanueva, Ravi Pathak, Patricia Castro, Michael M Ittmann, Andrew G Sikora, Seth P Lerner

Faculty, Staff and Student Publications

BACKGROUND: Non-metastatic muscle invasive urothelial bladder cancer (MIBC) has a poor prognosis and standard of care (SOC) includes neoadjuvant cisplatin-based chemotherapy (NAC) combined with cystectomy. Patients receiving NAC have at best

METHODS: We optimized engraftment conditions for primary MIBC tumors using the CAM-PDX model and tested concordance between cisplatin-based chemotherapy response of patients to matching PDX tumors using tumor growth coupled with immunohistochemistry markers of proliferation and apoptosis. We also tested select kinase inhibitor response on chemotherapy-resistant bladder cancers on the CAM-PDX using tumor growth measurements and immuno-detection of proliferation marker, Ki-67.

RESULTS: Our results show primary, NAC-resistant, MIBC tumors …

Design Of The Remedē System Therapy (Rēst) Study: A Prospective Non-Randomized Post-Market Study Collecting Clinical Data On Safety And Effectiveness Of The Remedē System For The Treatment Of Central Sleep Apnea, Lee R Goldberg, Henrik Fox, Christoph Stellbrink, Biykem Bozkurt, John P Boehmer, Jorge I Mora, Rahul Doshi, Timothy I Morgenthaler, Wayne C Levy, Timothy E Meyer, Scott W Mckane, Robin Germany, Remedē System Therapy Study Group

Faculty, Staff and Students Publications

Background: Central sleep apnea (CSA) is a disorder defined by lack of respiratory drive from the brain stem on breathing efforts. There is a lack of established therapies for CSA and most available therapies are limited by poor patient adherence, limited randomized controlled studies, and potentially adverse cardiovascular effects. The remedē System (ZOLL Respicardia, Inc., Minnetonka, Minnesota) uses transvenous phrenic nerve stimulation to stimulate the diaphragm, thereby restoring a more normal breathing pattern throughout the sleep period.

Methods: The remedē System Therapy (rēST) Study is a prospective non-randomized multicenter international study evaluating long-term safety and effectiveness of the remedē System …

Association Between Cause Of Kidney Failure And Fracture Incidence In A National Us Dialysis Population Cohort Study, Susan Ziolkowski, Sai Liu, Maria E Montez-Rath, Michelle Denburg, Wolfgang C Winkelmayer, Glenn M Chertow, Michelle M O'Shaughnessy

Faculty, Staff and Students Publications

Background: Bradycardia and asystole events are common among patients treated with maintenance hemodialysis. However, triggers of these events in patients on maintenance hemodialysis (HD), particularly during the long interdialytic period when these events cluster, are uncertain.

Methods: The Monitoring in Dialysis Study (MiD) enrolled 66 patients on maintenance HD who were implanted with loop recorders and followed for 6 months. We analyzed associations of predialysis laboratory values with clinically significant bradyarrhythmia or asystole (CSBA) during the 12 hours before an HD session. Associations with CSBA were analyzed with mixed-effect models. Adjusted negative binomial mixed-effect regression was used to estimate incidence …

Highlights Of Cardiovascular Disease Prevention Studies Presented At The 2022 European Society Of Cardiology Congress, Melody Hermel, Megan Pelter, Timothy Jordan, Azka Latif, Mohamed M Gad, Leandro Slipczuk, Dinesh Kalra, Salim S Virani

Faculty, Staff and Students Publications

Purpose of review: Focused review of select studies presented at the 2022 European Society of Cardiology Congress.

Recent findings: Included studies assessed the effects of aspirin and omega-3 fatty acid supplements on heart failure (ASCEND study); the impact of icosapent ethyl on ST-elevation MI incidence (REDUCE-IT); air temperature's effect on cardiovascular mortality (EXHAUSTION project); LVEF outcomes after troponin-guided neurohormonal blockade for the prevention of anthracycline toxicity; efficacy of routine stress testing after high-risk PCI (POST-PCI trial); influenza vaccine among patients with acute coronary syndromes (VIP-ACS trial); empagliflozin in patients with acute myocardial infarction (EMMY); effects of comprehensive imaging-based cardiovascular screening …

Human Loss-Of-Function Variants In The Serotonin 2c Receptor Associated With Obesity And Maladaptive Behavior, Yang He, Bas Brouwers, Hesong Liu, Hailan Liu, Katherine Lawler, Edson Mendes De Oliveira, Dong-Kee Lee, Yongjie Yang, Aaron R Cox, Julia M Keogh, Elana Henning, Rebecca Bounds, Aliki Perdikari, Vikram Ayinampudi, Chunmei Wang, Meng Yu, Longlong Tu, Nan Zhang, Na Yin, Junying Han, Nikolas A Scarcelli, Zili Yan, Kristine M Conde, Camille Potts, Jonathan C Bean, Mengjie Wang, Sean M Hartig, Lan Liao, Jianming Xu, Inês Barroso, Jacek Mokrosinski, Yong Xu, I Sadaf Farooqi

Children’s Nutrition Research Center Staff Publications

Serotonin reuptake inhibitors and receptor agonists are used to treat obesity, anxiety and depression. Here we studied the role of the serotonin 2C receptor (5-HT2CR) in weight regulation and behavior. Using exome sequencing of 2,548 people with severe obesity and 1,117 control individuals without obesity, we identified 13 rare variants in the gene encoding 5-HT2CR (HTR2C) in 19 unrelated people (3 males and 16 females). Eleven variants caused a loss of function in HEK293 cells. All people who carried variants had hyperphagia and some degree of maladaptive behavior. Knock-in male mice harboring a human loss-of-function HTR2C variant developed …

A Minimal Role For Synonymous Variation In Human Disease, Ryan S Dhindsa, Quanli Wang, Dimitrios Vitsios, Oliver S Burren, Fengyuan Hu, James E Dicarlo, Leonid Kruglyak, Daniel G Macarthur, Matthew E Hurles, Slavé Petrovski

Duncan NRI Faculty and Staff Publications

Synonymous mutations change the DNA sequence of a gene without affecting the amino acid sequence of the encoded protein. Although some synonymous mutations can affect RNA splicing, translational efficiency, and mRNA stability, studies in human genetics, mutagenesis screens, and other experiments and evolutionary analyses have repeatedly shown that most synonymous variants are neutral or only weakly deleterious, with some notable exceptions. Based on a recent study in yeast, there have been claims that synonymous mutations could be as important as nonsynonymous mutations in causing disease, assuming the yeast findings hold up and translate to humans. Here, we argue that there …

Neurobehavioral Deficits And A Progressive Ictogenesis In The Tetrodotoxin Model Of Epileptic Spasms, John T Le, Carlos J Ballester-Rosado, James D Frost, John W Swann

Duncan NRI Faculty and Staff Publications

Objective: Our goal was to determine whether animals with a history of epileptic spasms have learning and memory deficits. We also used continuous (24/7) long-term electroencephalographic (EEG) recordings to evaluate the evolution of epileptiform activity in the same animals over time.

Methods: Object recognition memory and object location memory tests were undertaken, as well as a matching to place water maze test that evaluated working memory. A retrospective analysis was undertaken of long-term video/EEG recordings from rats with epileptic spasms. The frequency and duration of the ictal events of spasms were quantified.

Results: Rats with a history of epileptic spasms …

Clinical And Demographic Factors Contributing To Asparaginase-Associated Toxicities In Children With Acute Lymphoblastic Leukemia, Priyadarshani Dharia, Michael D Swartz, M Brooke Bernhardt, Han Chen, M Monica Gramatges, Philip J Lupo, Austin L Brown, Michael E Scheurer

Center for Medical Ethics and Health Policy Staff Publications

A total of 548 patients (age range: 1-22 years, 60.4% Hispanic, 55.8% male) diagnosed with acute lymphoblastic leukemia were reviewed for pegaspargase-associated hypersensitivity (14.8%), hyperbilirubinemia (9.7%), venous thromboembolism (VTE, 9.7%), and pancreatitis (5.3%). Odds ratios (OR) and 95% confidence intervals (CI) evaluated associations between clinical factors and each toxicity, cumulative number of toxicities, and toxicity clusters identified using k-mode analysis. Most (68.9%) did not experience any toxicity, 24.6% experienced one toxicity, and 6.3% two or more. Age >10 years was associated with hyperbilirubinemia (OR = 3.83; 95% CI: 1.64-8.95), pancreatitis (OR = 3.72; 95% CI: 1.29-10.68), VTE (OR = 4.65; …