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Interview With Kieth Roper, Utah State University Special Collections & Archives

Utah State University COVID-19 Oral History Collection

No abstract provided.

Interview With Alexa Sand, Utah State University Special Collections & Archives

Utah State University COVID-19 Oral History Collection

No abstract provided.

Interview With Ridah Shoorbajee, Utah State University Special Collections & Archives

Utah State University COVID-19 Oral History Collection

No abstract provided.

Interview With James Taylor, Utah State University Special Collections & Archives

Utah State University COVID-19 Oral History Collection

No abstract provided.

Interview With Katie Trepanier, Utah State University Special Collections & Archives

Utah State University COVID-19 Oral History Collection

No abstract provided.

Interview With Jenn Van Cott, Utah State University Special Collections & Archives

Utah State University COVID-19 Oral History Collection

No abstract provided.

Interview With Joseph Ward, Utah State University Special Collections & Archives

Utah State University COVID-19 Oral History Collection

No abstract provided.

Interview With Ken White, Utah State University Special Collections & Archives

Utah State University COVID-19 Oral History Collection

No abstract provided.

Interview With Matt White, Utah State University Special Collections & Archives

Utah State University COVID-19 Oral History Collection

No abstract provided.

Interview With Connie Whitworth, Utah State University Special Collections & Archives

Utah State University COVID-19 Oral History Collection

No abstract provided.

Interview With Celina Wille, Utah State University Special Collections & Archives

Utah State University COVID-19 Oral History Collection

No abstract provided.

Interview With Kelsey Winter, Utah State University Special Collections & Archives

Utah State University COVID-19 Oral History Collection

No abstract provided.

Interview With Naomi Yoko Ward, Utah State University Special Collections & Archives

Utah State University COVID-19 Oral History Collection

No abstract provided.

Healthy Acadia Downeast Community Opioid Response Program: Year 1 Summary, Mary Lindsey Smith Phd, Evelyn Ali Bs, Tyler Egeland Ba, Katie Rosingana Ba

Substance Use Research & Evaluation

The Downeast Substance Treatment Network is a group of diverse organizations working to improve integration and access to treatments and services for people with substance use disorder. The consortium’s Rural Communities Opioid Response Program grant project aims to: (1) expand the reach of their treatment network, (2) increase awareness and practice of harm reduction, and (3) facilitate transitions of care to improve partner efficacy. This project included a mixed-methods evaluation led by Catherine E. Cutler Institute’s Substance Use Research and Evaluation Team (SURE). This year 1 summary presentation includes feedback from program partners and key informants, in addition to HRSA-required …

Education Research: Neurologic Education In Physician Assistant Programs, Carl Garubba

Physician Assistant Studies | Faculty Scholarship

Background and Objectives A growing number of advanced practice providers (APPs) are entering neurologic practice, and educational initiatives focused on postgraduate training in neurology for these providers are growing in turn. Neurologic education in APP degree programs is not well defined, which limits the ability to tailor these initiatives to the specific needs of APPs. We aim to describe neurologic education in physician assistant (PA) degree programs to better inform these efforts.

Methods The 2018 American Academy of Neurology clerkship director survey was adapted for directors of PA programs via an iterative approach. The survey was distributed to program directors …

Assessing Cerebral Blood Flow, Oxygenation And Cytochrome C Oxidase Stability In Preterm Infants During The First 3 Days After Birth, Ajay Rajaram, Daniel Milej, Marianne Suwalski, Lilian Kebaya, Matthew Kewin, Lawrence Yip, Sandrine De Ribaupierre, Victor Han, Mamadou Diop, Soume Bhattacharya, Keith St. Lawrence

Paediatrics Publications

A major concern with preterm birth is the risk of neurodevelopmental disability. Poor cerebral circulation leading to periods of hypoxia is believed to play a significant role in the etiology of preterm brain injury, with the first three days of life considered the period when the brain is most vulnerable. This study focused on monitoring cerebral perfusion and metabolism during the first 72 h after birth in preterm infants weighing less than 1500 g. Brain monitoring was performed by combining hyperspectral near-infrared spectroscopy to assess oxygen saturation and the oxidation state of cytochrome c oxidase (oxCCO), with diffuse correlation spectroscopy …

Change In Pre- And In-Service Early Childhood Educators’ Knowledge, Self-Efficacy, And Intentions Following An E-Learning Course In Physical Activity And Sedentary Behaviour: A Pilot Study, Brianne A. Bruijns, Leigh M. Vanderloo, Andrew M. Johnson, Kristi B. Adamo, Shauna M. Burke, Valerie Carson, Rachel Heydon, Jennifer D. Irwin, Patti Jean Naylor, Brian W. Timmons, Patricia Tucker

Paediatrics Publications

Background: Early childhood educators (ECEs) are the primary daytime role models for many young children, and are responsible for facilitating physical activity (PA) opportunities and minimizing sedentary behaviour (SB) in childcare. However, they have reportedly received little related education in their pre-service training. The purpose of the Training pre-service EArly CHildhood educators in physical activity (TEACH) pilot study was to explore changes in pre- and in-service ECEs’ knowledge, self-efficacy, behavioural intention, and perceived behavioural control following the TEACH e-Learning course in PA and SB. Methods: Pre-service ECEs were purposefully recruited from three Canadian colleges, while in-service ECEs were recruited via …

Fetal Sex Impacts Birth To Placental Weight Ratio And Umbilical Cord Oxygen Values With Implications For Regulatory Mechanisms, Bryan S. Richardson, Akasham Rajagopaul, Barbra De Vrijer, Genevieve Eastabrook, Timothy R.H. Regnault

Obstetrics & Gynaecology Publications

Background: We determined the effect of fetal sex on birth/placental weight and umbilical vein and artery oxygen values with implications for placental efficiency and regulatory mechanisms underlying fetal–placental growth differences. Methods: A hospital database was used to obtain birth/placental weight, cord PO2 and other information on patients delivering between Jan 1, 1990 and Jun 15, 2011 with GA > 34 weeks (N = 69,836). Oxygen saturation was calculated from the cord PO2 and pH data, while fractional O2 extraction was calculated from the oxygen saturation data. The effect of fetal sex on birth/placental weight, cord PO2, O2 saturation, and fractional O2 …

Ecological Interchangeability: Supporting Team Adaptive Expertise In Moments Of Disruption, Sayra Cristancho, Emily Field, Lorelei Lingard, Taryn Taylor, Kathryn Hibbert, Graham Thompson, William Hibbert

Obstetrics & Gynaecology Publications

While undesirable, unexpected disruptions offer unique opportunities to enact adaptive expertise. For adaptive expertise to flourish, individuals and teams must embrace both efficiency and adaptation. While some industries do it readily, others continue to struggle with the tension between efficiency and adaptation, particularly when otherwise stable situations are unexpectedly disrupted. For instance, in healthcare settings, the efficiency mandate for strict compliance with scopes of practice can deter teams from using the adaptive strategy of making their members interchangeable. Yet, interchangeability has been hinted as a key capacity of today’ teams that are required to navigate fluid team structures. Because interchangeability …

Transforming Possible Risk Into Certain Harm: A Critical Interpretive Synthesis Of The Literature On Perinatal Cannabis Use, Rachael Pack, Grace Hilton, Facundo Garcia-Bournissen, Taryn Taylor

Obstetrics & Gynaecology Publications

Substance use in pregnancy has been a prominent public health concern for the last several decades. Since the legalization of cannabis in Canada and across several American states, cannabis use during pregnancy has gained considerable public health, scientific, and media attention. This critical interpretive synthesis explores how the problem of cannabis use in pregnancy is constructed in the scientific literature and illuminates clinical, social, and political responses this construction engenders. The state of empirical evidence regarding the impact of perinatal cannabis use is fraught; a number of studies, of variable quality, have found no associations between cannabis use and adverse …

Expression And Localization Of Nrf2/Keap1 Signalling Pathway Genes In Mouse Preimplantation Embryos Exposed To Free Fatty Acids., Grace Dionne, Michele D. Calder, Dean H Betts, Basim Abu Rafea, Andrew J Watson

Obstetrics & Gynaecology Publications

Obese women experience greater incidence of infertility, with reproductive tracts exposing preimplantation embryos to elevated free fatty acids (FFA) such as palmitic acid (PA) and oleic acid (OA). PA treatment impairs mouse preimplantation development in vitro, while OA co-treatment rescues blastocyst development of PA treated embryos. In the present study, we investigated the effects of PA and OA treatment on NRF2/Keap1 localization, and relative antioxidant enzyme (Glutathione peroxidase; Gpx1, Catalase; Cat, Superoxide dismutase; Sod1 and γ-Glutamylcysteine ligase catalytic unit; Gclc) mRNA levels, during in vitro mouse preimplantation embryo development. Female mice were superovulated, mated, and embryos cultured in the presence …

Resilience Amongst Ontario Registered Practical Nurses In Long-Term Care Homes During Covid-19: A Grounded Theory Study, Denise M. Connelly, Anna Garnett, Nancy Snobelen, Nicole Guitar, Cecilia Flores-Sandoval, Samir Sinha, Jen Calver, Diana Pearson, Tracy Smith-Carrier

Physical Therapy Publications

Aims: This study aimed to understand how the personal and professional resilience of Registered Practical Nurses working in long-term care (LTC) homes in Ontario were impacted during the Coronavirus 2019 pandemic. Background: Registered Practical Nurses are primary regulated healthcare providers that have worked in Ontario LTC homes during the COVID-19 pandemic. As frontline workers, they have experienced increased stress secondary to lockdowns, changing Ministry of Health recommendations, social isolation and limited resources. LTC homes experienced almost a third of all COVID-19-related deaths in Ontario. Understanding registered practical nurses' (RPNs) resilience in this context is vital in developing the programs and …

Principles Of Dormancy Evident In High-Grade Serous Ovarian Cancer, Trevor G. Shepherd, Frederick A. Dick

Paediatrics Publications

In cancer, dormancy refers to a clinical state in which microscopic residual disease becomes non-proliferative and is largely refractory to chemotherapy. Dormancy was first described in breast cancer where disease can remain undetected for decades, ultimately leading to relapse and clinical presentation of the original malignancy. A long latency period can be explained by withdrawal from cell proliferation (cellular dormancy), or a balance between proliferation and cell death that retains low levels of residual disease (tumor mass dormancy). Research into cellular dormancy has revealed features that define this state. They include arrest of cell proliferation, altered cellular metabolism, and unique …

Rethinking Walkability And Developing A Conceptual Definition Of Active Living Environments To Guide Research And Practice, Melissa Tobin, Samantha Hajna, Kassia Orychock, Nancy Ross, Megan Devries, Paul J. Villeneuve, Lawrence D. Frank, Gavin R. Mccormack, Rania Wasfi, Madeleine Steinmetz-Wood, Jason Gilliland, Gillian L. Booth, Meghan Winters, Yan Kestens, Kevin Manaugh, Daniel Rainham, Lise Gauvin, Michael J. Widener, Nazeem Muhajarine, Hui Luan, Daniel Fuller

Paediatrics Publications

Background: Walkability is a popular term used to describe aspects of the built and social environment that have important population-level impacts on physical activity, energy balance, and health. Although the term is widely used by researchers, practitioners, and the general public, and multiple operational definitions and walkability measurement tools exist, there are is no agreed-upon conceptual definition of walkability. Method: To address this gap, researchers from Memorial University of Newfoundland hosted “The Future of Walkability Measures Workshop” in association with researchers from the Canadian Urban Environmental Health Research Consortium (CANUE) in November 2017. During the workshop, trainees, researchers, and practitioners …

Clinical Utility Of Combinatorial Pharmacogenomic Testing In Depression: A Canadian Patient- And Rater-Blinded, Randomized, Controlled Trial, Arun K. Tiwari, Clement C. Zai, C. Anthony Altar, Julie Anne Tanner, Paige E. Davies, Paul Traxler, James Li, Elizabeth S. Cogan, Matthew T. Kucera, Ana Gugila, Nicole Braganza, Heather Emmerson, Gwyneth Zai, Daniel J. Müller, Robert Levitan, Stefan Kloiber, Zafiris J. Daskalakis, Benicio N. Frey, James M. Bowen, Jean Eric Tarride, Richard Tytus, Ranjith Chandrasena, Nicholas Voudouris, Valerie H. Taylor, Raymond Tempier, Verinder Sharma

Paediatrics Publications

The pharmacological treatment of depression consists of stages of trial and error, with less than 40% of patients achieving remission during first medication trial. However, in a large, randomized-controlled trial (RCT) in the U.S. (“GUIDED”), significant improvements in response and remission rates were observed in patients who received treatment guided by combinatorial pharmacogenomic testing, compared to treatment-as-usual (TAU). Here we present results from the Canadian “GAPP-MDD” RCT. This 52-week, 3-arm, multi-center, participant- and rater-blinded RCT evaluated clinical outcomes among patients with depression whose treatment was guided by combinatorial pharmacogenomic testing compared to TAU. The primary outcome was symptom improvement (change …

Genetic Evidence Supports The Development Of Slc26a9 Targeting Therapies For The Treatment Of Lung Disease, Jiafen Gong, Gengming He, Cheng Wang, Claire Bartlett, Naim Panjwani, Scott Mastromatteo, Fan Lin, Katherine Keenan, Julie Avolio, Anat Halevy, Michelle Shaw, Mohsen Esmaeili, Guillaume Côté-Maurais, Damien Adam, Stéphanie Bégin, Candice Bjornson, Mark Chilvers, Joe Reisman, April Price, Michael Parkins, Richard Van Wylick, Yves Berthiaume, Lara Bilodeau, Dimas Mateos-Corral, Daniel Hughes, Mary J. Smith

Paediatrics Publications

Over 400 variants in the cystic fibrosis (CF) transmembrane conductance regulator (CFTR) are CF-causing. CFTR modulators target variants to improve lung function, but marked variability in response exists and current therapies do not address all CF-causing variants highlighting unmet needs. Alternative epithelial ion channel/transporters such as SLC26A9 could compensate for CFTR dysfunction, providing therapeutic targets that may benefit all individuals with CF. We investigate the relationship between rs7512462, a marker of SLC26A9 activity, and lung function pre- and post-treatment with CFTR modulators in Canadian and US CF cohorts, in the general population, and in those with chronic obstructive pulmonary disease …

Surgical Interventions In Velopharyngeal Dysfunction: Comparative Perceptual Speech And Nasometric Outcomes For Three Techniques, Ryan Instrum, Agnieszka Dzioba, Anne Dworschak-Stokan, Murad Husein

Paediatrics Publications

Background: The aim of this study was to evaluate speech outcomes following surgical intervention for velopharyngeal dysfunction (VPD). Perceptual speech outcome data were subsequently analyzed in conjunction with patient factors such as congenital abnormalities, presence of cleft lip and/or palate, and age of repair. We hope to aid in the eventual creation of treatment algorithms for VPD, allowing practitioners to tailor surgical technique selection to patient factors. Methods: A retrospective analysis was performed for all patients who underwent surgical correction of VPD at London Health Sciences Centre between the years 2005 and 2018. Two hundred and two consecutive VPD patients …

The ‘New Normal’ Includes Online Prenatal Exercise: Exploring Pregnant Women’S Experiences During The Pandemic And The Role Of Virtual Group Fitness On Maternal Mental Health, Cristina Silva-Jose, Taniya S. Nagpal, Javier Coterón, Ruben Barakat, Michelle F. Mottola

Paediatrics Publications

Background: Prenatal anxiety and depressive symptoms have significantly increased since the onset of the coronavirus (COVID-19) pandemic In addition, home confinement regulations have caused a drastic increase in time spent sedentary. Online group fitness classes may be an effective strategy that can increase maternal physical activity levels and improve mental health outcomes by providing an opportunity for social connectedness. The present study explores the experiences of pregnant women who participated in an online group exercise program during the pandemic and identifies relationships with maternal mental health and well-being. In addition, we present person-informed recommendations on how to improve the delivery …

Quantifying The Amount Of Physical Rehabilitation Received By Individuals Living With Neurological Conditions In The Community: A Scoping Review, Tyler M. Saumur, Sarah Gregor, Yijun Xiong, Janelle Unger

Neuroscience Institute Publications

Background: Physical rehabilitation is often prescribed immediately following a neurological event or a neurological diagnosis. However, many individuals require physical rehabilitation after hospital discharge. The purpose of this scoping review was to determine the amount of physical rehabilitation that individuals living in the community with neurological conditions receive to understand current global practices and assess gaps in research and service use. Methods: This scoping review included observational studies that 1) involved adults living with a neurological condition, and 2) quantified the amount of rehabilitation being received in the community or outpatient hospital setting. Only literature published in English was considered. …

Progression Of Atherosclerosis With Carnitine Supplementation: A Randomized Controlled Trial In The Metabolic Syndrome, Amer M. Johri, Marie France Hétu, Daren K. Heyland, Julia E. Herr, Jennifer Korol, Shawna Froese, Patrick A. Norman, Andrew G. Day, Murray F. Matangi, Erin D. Michos, Stephen A. Lahaye, Fraser W. Saunders, J. David Spence

Neuroscience Institute Publications

Background: L-carnitine (L-C), a ubiquitous nutritional supplement, has been investigated as a potential therapy for cardiovascular disease, but its effects on human atherosclerosis are unknown. Clinical studies suggest improvement of some cardiovascular risk factors, whereas others show increased plasma levels of pro-atherogenic trimethylamine N-oxide. The primary aim was to determine whether L-C therapy led to progression or regression of carotid total plaque volume (TPV) in participants with metabolic syndrome (MetS). Methods: This was a phase 2, prospective, double blinded, randomized, placebo-controlled, two-center trial. MetS was defined as ≥ 3/5 cardiac risk factors: elevated waist circumference; elevated triglycerides; reduced HDL-cholesterol; elevated …