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2022

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"So Many Hopes": A Qualitative Content Analysis Of Children's Picture Books That Portray Refugees, Janine J. Darragh, Jane E. Kelley Dec 2022

"So Many Hopes": A Qualitative Content Analysis Of Children's Picture Books That Portray Refugees, Janine J. Darragh, Jane E. Kelley

Reading Horizons: A Journal of Literacy and Language Arts

Researchers used content analysis to analyze 40 award-winning and “best of” children’s picture books that portray refugees to answer the questions: How are refugees depicted in picture books? What messages are embedded in those depictions? Results show patterns and themes regarding depictions of trauma and violence in conjunction with setting as well as the portrayal of the arts as a vehicle for refugees to ignite personal agency in coping with the trauma they experienced. Implications for practice are discussed.


Literacy Coaching For Instructional Change In Guided Reading: Navigating Form And Function, Denise N. Morgan, Celeste C. Bates, Robin Griffith Dec 2022

Literacy Coaching For Instructional Change In Guided Reading: Navigating Form And Function, Denise N. Morgan, Celeste C. Bates, Robin Griffith

Reading Horizons: A Journal of Literacy and Language Arts

The purpose of this research was to examine how one teacher’s guided reading instruction evolved while engaged in a job-embedded professional development experience across the school year. The teacher taught and debriefed multiple guided reading lessons per visit with a literacy coach. The authors employed qualitative methods to analyze the transcripts from interviews and pre- and postconferences, written reflections, and field notes from the lessons. Findings demonstrate that the teacher shifted from being hyper-focused on the form of guided reading to the actual function of guided reading. Initially, she concentrated on text level, time and planning, and management, which the …


Retrospective Evaluation Of Depression Screening Process Among Older Adult Patients In Primary Care For Quality Improvement., Ashley Dru Larson Dec 2022

Retrospective Evaluation Of Depression Screening Process Among Older Adult Patients In Primary Care For Quality Improvement., Ashley Dru Larson

Doctor of Nursing Practice Papers

Background: Depression is not a normal process of aging; it is a diagnosable and treatable medical condition. The US Preventive Services Task Force (USPSTF) recommends that older adults be screened for depression annually.

Aim: The purpose of this evidence-based practice (EBP) project was to evaluate the depression screening process for older adults (age 65+) in a primary health care setting and provide recommendations to the primary health care clinic for improving it.

Methods: This EBP project involved collecting retrospective data from August to October 2022, including aggregate data (demographics), from all older adults who were seen in …


Jackery Power Station: Stockton Shelter For The Homeless, Angela Vides, Abigail Equinoa, Carolyn Ly, Estephanie Huerta Dec 2022

Jackery Power Station: Stockton Shelter For The Homeless, Angela Vides, Abigail Equinoa, Carolyn Ly, Estephanie Huerta

Occupational Therapy Student Research

The community group, San Joaquin County Mobile Clinic, aims to improve the health outcomes of vulnerable populations by providing low-cost preventative healthcare and treatment options. This includes wound care, vaccinations, and assistance with accessing medical appointments and health insurance. However, research has shown that those without housing do not have adequate access to stable power sources to charge mobile devices to aid healthcare needs and access resources. The Jackery Power Station, which falls under the category of consumer access, priorities, and benefits over the lifespan, will attempt to address this barrier.

An estimated 2,631 individuals in San Joaquin county are …


Kitchen Stories, Terral Christopher, Nazifa Fazil, Lauren Jew, Ken Zhu Dec 2022

Kitchen Stories, Terral Christopher, Nazifa Fazil, Lauren Jew, Ken Zhu

Occupational Therapy Student Research

Individuals with ASD may experience difficulties with independent living skills, such as financial management, home management and meal preparation. An occupation such as cooking typically includes methods such as task-analysis, systemic prompting, cueing, modeling, visual support and feedback, which can be challenging for the ASD population.

Kitchen Stories is a video-based, cross-media cooking platform whose mission is to “to empower people to cook a fresh meal every day.” Although cooking is an essential part of everyday life, the creators of the platform understand that many people struggle with it for a variety of reasons. Nevertheless, they are confident that anyone …


App-Licable Techology, Wynter Hale, Cierilyn Legaspi, Juan Garcia, Alex Zamora Dec 2022

App-Licable Techology, Wynter Hale, Cierilyn Legaspi, Juan Garcia, Alex Zamora

Occupational Therapy Student Research

Autism Spectrum Disorder (ASD) has seen an increase in prevalence in the United States presenting in 1 in 59 children. ASD presents with an array of symptoms that impact various aspects of life including but not limited to, social interaction, attention, and behavioral modulation (Voss et al., 2019). Meristem is a transitional program for individuals ages 18-28 that prepares young adults on the transition of adulthood while coping with the various symptoms of ASD. At our fieldwork site, our collective mission has been to focus on sensory and mood self-regulation to improve the individual's independence during situations. Technology can play …


Adaptive Seating, Julie Jones, Mckayla Wallace, Marisa Given, Nisha Rustia, George Cardenas Dec 2022

Adaptive Seating, Julie Jones, Mckayla Wallace, Marisa Given, Nisha Rustia, George Cardenas

Occupational Therapy Student Research

Children’s sensory needs are impacting their ability to attend to their speech language pathology treatment sessions in a meaningful and effective way. There is a gap in the education for SLPs on sensory integration which limits their ability to recognize the challenges and know how to support them in a productive way.


Insight Timer, Jocelyn Ong Najera, Joshua Mark Dano, Staphany Jimenez, Arthur Lui, Nancy Smith Dec 2022

Insight Timer, Jocelyn Ong Najera, Joshua Mark Dano, Staphany Jimenez, Arthur Lui, Nancy Smith

Occupational Therapy Student Research

Mission Statement: To provide cost-effective avenues for tangible stress reduction and relief for low-income communities such as Wellspring.

Overview: Insight Timer is a mobile application that offers guided meditation to calm the mind, reduce anxiety, manage stress, sleep deeply, and improve happiness. While also offering calm music, courses, live events, and workshops in various languages. (Insight Network, Inc., n.d.)

Problem Statement: Individuals who face poverty experience mental challenges due to stressors caused by poverty due to insecurity and uncertainty about food, housing, and income. Low-income communities tend to have limited resources, poor housing, experience high crime rates, violence rate, and …


Cocreation In Health Workforce Planning To Shape The Future Of The Health Care System In The Philippines, Harvy Joy Liwanag, Jhanna Uy, Mary Ruth Politico, Mary Joy Padilla, Ma. Catherine Arzobal, Kaycee Manuel, Angeli Loren Cagouia, Pretchell Tolentino, Annika Frahsa, Kenneth Ronquillo Dec 2022

Cocreation In Health Workforce Planning To Shape The Future Of The Health Care System In The Philippines, Harvy Joy Liwanag, Jhanna Uy, Mary Ruth Politico, Mary Joy Padilla, Ma. Catherine Arzobal, Kaycee Manuel, Angeli Loren Cagouia, Pretchell Tolentino, Annika Frahsa, Kenneth Ronquillo

Health Sciences Faculty Publications

Background

The Philippines passed landmark legislation in 2019 on universal health coverage, including reforms in the development of its health workforce, an essential building block of responsive health care systems.

Health Workforce Planning Cocreation Process

We based our planning process on a model of cocreation defined as sharing power and decision making to solve problems collaboratively and build consensus around action. Through cocreation with policy makers, researchers, and other stakeholders, we performed projection studies on 10 selected health professions and estimated the need for primary care at national and subnational levels, which was the most extensive health workforce projection carried …


Independence Testing-Based Approach To Causal Discovery Under Measurement Error And Linear Non-Gaussian Models, Haoyue Dai, Peter Spirtes, Kun Zhang Dec 2022

Independence Testing-Based Approach To Causal Discovery Under Measurement Error And Linear Non-Gaussian Models, Haoyue Dai, Peter Spirtes, Kun Zhang

Machine Learning Faculty Publications

Causal discovery aims to recover causal structures generating the observational data. Despite its success in certain problems, in many real-world scenarios the observed variables are not the target variables of interest, but the imperfect measures of the target variables. Causal discovery under measurement error aims to recover the causal graph among unobserved target variables from observations made with measurement error. We consider a specific formulation of the problem, where the unobserved target variables follow a linear non-Gaussian acyclic model, and the measurement process follows the random measurement error model. Existing methods on this formulation rely on non-scalable over-complete independent component …


Design, Synthesis, And Evaluation Of N-Methylated H2r2w4, Talal Alrubaie Dec 2022

Design, Synthesis, And Evaluation Of N-Methylated H2r2w4, Talal Alrubaie

Pharmaceutical Sciences (MS) Theses

Antimicrobial peptides (AMPs) are potential candidates for developing antibiotics against multidrug-resistant bacteria. We have recently developed a potent cyclic AMP containing histidine (H), arginine (R), and tryptophan (W) residues named [H2R2W4]. This peptide showed antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) and Staphylococcus aureus (SA) with a minimum inhibitor concentration (MIC) of 3.1 μg/mL and a MIC of 6.2 μg/mL for Escherichia coli (E. coli). However, it displayed a mild cytotoxicity with cell viability of approximately 80% against normal human lung cells (MRC-5) and ~60% against normal human kidney cells (HEK-293) at the …


Confidence And Anxiety When Returning To Play Post-Injury, Gianna Sciarappa Dec 2022

Confidence And Anxiety When Returning To Play Post-Injury, Gianna Sciarappa

Honors Senior Capstone Projects

No abstract provided.


The Eudemonic And Hedonic Impacts Of Attending Live And Virtual Music And Art Events, Philippa Kirwan, Samantha Morris Dec 2022

The Eudemonic And Hedonic Impacts Of Attending Live And Virtual Music And Art Events, Philippa Kirwan, Samantha Morris

Articles

This paper examines the under-investigated well-being impacts of arts and music events attendance, in both a live and virtual capacity. Using eudaimonia and hedonia as a measure for well-being, three objectives were investigated; 1) Do live arts and music events meet attendees eudemonic and hedonic needs? 2) Do virtual arts and music events meet attendees eudemonic and hedonic needs? 3) How do live and virtual music and art events compare in meeting attendees eudemonic and hedonic needs? The study focused on attendee’s experiences having attended both live and virtual events. Using nine semi-structured interviews this research found that live music …


A Candle In The Labyrinth: A Guide For Immigration Attorneys To Assert Habeas Corpus After Dhs V. Thuraissigiam, Joshua J. Schroeder Dec 2022

A Candle In The Labyrinth: A Guide For Immigration Attorneys To Assert Habeas Corpus After Dhs V. Thuraissigiam, Joshua J. Schroeder

UC Law Constitutional Quarterly

In the summer of 2020, immigration law seemed to become the gravitational center of presidential power. After the Supreme Court decided several immigration cases in favor of the executive department, former President Trump cited “the DACA case” to support a new constitutional theory that “[t]he Supreme Court gave the president of the United States powers that nobody thought the president had.” Accordingly, Trump began to issue presidential legislation including “an immigration plan, a health care plan, and various other plans.”

Trump also began to occupy cities that were politically opposed to his presidency with ICE and CBP agents, including BORTAC …


Developing Novel Remote Camera Approaches To Assess And Monitor The Population Status Of Australian Sea Lions, Mathew Hourston, Daniela Waltrick, Stuart Blight, Ainslie Denham, Alex Hesp, Steve Taylor Dec 2022

Developing Novel Remote Camera Approaches To Assess And Monitor The Population Status Of Australian Sea Lions, Mathew Hourston, Daniela Waltrick, Stuart Blight, Ainslie Denham, Alex Hesp, Steve Taylor

Fisheries Research Reports

This project trialled the use of remote cameras to monitor the relative abundance of Australian sea lions (ASLs, Neophoca cinerea) at three Western Australian (WA) breeding colonies. The research was undertaken by the Department of Primary Industries and Regional Development (DPIRD) to assess whether the analysis of camera footage could be used to estimate ASL relative abundance, providing an alternative to the traditional “boots on the ground” approach (hereon in “BoG”) of visiting colonies to count animals. This report outlines the strengths and limitations of this novel approach rather than providing an update on the population status of ASLs. …


Columbia Chronicle (09/26/2022), Columbia College Chicago Dec 2022

Columbia Chronicle (09/26/2022), Columbia College Chicago

Columbia Chronicle

Student newspaper from September 26, 2022 entitled The Columbia Chronicle. This issue is 20 pages. Cover story: "The Creatives". Editors-in-Chief: Anna Busalacchi & Noah Jennings.


Structural Covariance Of The Ventral Visual Stream Predicts Posttraumatic Intrusion And Nightmare Symptoms: A Multivariate Data Fusion Analysis, Nathaniel G. Harnett, Katherine E. Finegold, Lauren A.M. Lebois, Sanne J.H. Van Rooij, Timothy D. Ely, Vishnu P. Murty, Tanja Jovanovic, Steven E. Bruce, Stacey L. House, Francesca L. Beaudoin, Xinming An, Donglin Zeng, Thomas C. Neylan, Gari D. Clifford, Sarah D. Linnstaedt, Laura T. Germine, Kenneth A. Bollen, Scott L. Rauch, John P. Haran, Alan B. Storrow, Christopher Lewandowski, Paul I. Musey, Phyllis L. Hendry, Sophia Sheikh, Christopher W. Jones, Brittany E. Punches, Michael C. Kurz, Robert A. Swor, Lauren A. Hudak, Jose L. Pascual, Mark J. Seamon, Erica Harris Dec 2022

Structural Covariance Of The Ventral Visual Stream Predicts Posttraumatic Intrusion And Nightmare Symptoms: A Multivariate Data Fusion Analysis, Nathaniel G. Harnett, Katherine E. Finegold, Lauren A.M. Lebois, Sanne J.H. Van Rooij, Timothy D. Ely, Vishnu P. Murty, Tanja Jovanovic, Steven E. Bruce, Stacey L. House, Francesca L. Beaudoin, Xinming An, Donglin Zeng, Thomas C. Neylan, Gari D. Clifford, Sarah D. Linnstaedt, Laura T. Germine, Kenneth A. Bollen, Scott L. Rauch, John P. Haran, Alan B. Storrow, Christopher Lewandowski, Paul I. Musey, Phyllis L. Hendry, Sophia Sheikh, Christopher W. Jones, Brittany E. Punches, Michael C. Kurz, Robert A. Swor, Lauren A. Hudak, Jose L. Pascual, Mark J. Seamon, Erica Harris

Psychology Faculty Works

Visual components of trauma memories are often vividly re-experienced by survivors with deleterious consequences for normal function. Neuroimaging research on trauma has primarily focused on threat-processing circuitry as core to trauma-related dysfunction. Conversely, limited attention has been given to visual circuitry which may be particularly relevant to posttraumatic stress disorder (PTSD). Prior work suggests that the ventral visual stream is directly related to the cognitive and affective disturbances observed in PTSD and may be predictive of later symptom expression. The present study used multimodal magnetic resonance imaging data (n = 278) collected two weeks after trauma exposure from the AURORA …


College Street Journal (December 2022), College Of The Holy Cross Dec 2022

College Street Journal (December 2022), College Of The Holy Cross

College Street Journal

College Street Journal serves as a student platform for business-related news, opportunities and resources at Holy Cross. Readers will discover a broad range of important topics from relevant news and economic issues, career development opportunities and advice, as well as Ciocca center and campus-wide opportunities to grow outside of the classroom.

Highlights of this edition include the World Cup, holiday economics, update on Ukraine, credit, Bloomberg Terminals, carbon neutrality, alumni interviews, and a faculty editorial.


Newsletter Catholic Deaf Of Detroit, December 2022 Dec 2022

Newsletter Catholic Deaf Of Detroit, December 2022

Newsletter Catholic Deaf of Detroit

A newsletter published for Deaf Catholics in Detroit, MI

Newsletter Catholic Deaf of Detroit Finding Aid


A Comparison Of Logistic, Ridge, And Lasso Regression With Heart Failure Risk Data: Effects Of Sample Size, Predictor Correlation, And Predictor Weight On Outcome Accuracy, Mahmoud M. Aljuhani Dec 2022

A Comparison Of Logistic, Ridge, And Lasso Regression With Heart Failure Risk Data: Effects Of Sample Size, Predictor Correlation, And Predictor Weight On Outcome Accuracy, Mahmoud M. Aljuhani

Electronic Theses and Dissertations

Logistic Regression (LR), LASSO regression, and RIDGE regression are standard classification techniques for predicting a dichotomous output. Since these methods are applied for similar purposes and have different features, it is crucial to evaluate the performance of these methods under different controlled conditions. With this information, researchers can apply the optimal method for specific conditions.

Following previous research, which reported the effects of conditions such as sample size and multicollinearity on the performance of the classification methods, this research focused on the effects of when sample size, level of predictor collinearity, and predictor variable weight are controlled on the performance …


Neural Recovery After Cortical Injury: Effects Of Msc Derived Extracellular Vesicles On Motor Circuit Remodeling In Rhesus Monkeys, Samantha Calderazzo, Margaret Covert, Diego De Alba, Bethany E. Bowley, Monica A. Pessina, Douglas L. Rosene, Benjamin Buller, Maria Medalla, Tara L. Moore Dec 2022

Neural Recovery After Cortical Injury: Effects Of Msc Derived Extracellular Vesicles On Motor Circuit Remodeling In Rhesus Monkeys, Samantha Calderazzo, Margaret Covert, Diego De Alba, Bethany E. Bowley, Monica A. Pessina, Douglas L. Rosene, Benjamin Buller, Maria Medalla, Tara L. Moore

Neurology Articles

Reorganization of motor circuits in the cortex and corticospinal tract are thought to underlie functional recovery after cortical injury, but the mechanisms of neural plasticity that could be therapeutic targets remain unclear. Recent work from our group have shown that systemic treatment with mesenchymal stem cell derived (MSCd) extracellular vesicles (EVs) administered after cortical damage to the primary motor cortex (M1) of rhesus monkeys resulted in a robust recovery of fine motor function and reduced chronic inflammation. Here, we used immunohistochemistry for cfos, an activity-dependent intermediate early gene, to label task-related neurons in the surviving primary motor and premotor cortices, …


Minutes, Executive Committee Meeting, Thursday, December 1, 2022, College Of Liberal Arts Executive Committee Dec 2022

Minutes, Executive Committee Meeting, Thursday, December 1, 2022, College Of Liberal Arts Executive Committee

Executive Committee Minutes

No abstract provided.


The First Amendment And Military Justice: Threats To Political Neutrality, Joshua Paldino Dec 2022

The First Amendment And Military Justice: Threats To Political Neutrality, Joshua Paldino

Notre Dame Law Review Reflection

This backdrop illustrates a throughline that runs throughout, and creates tension within, the Military Justice system. On the one hand, there is a need to protect the individual rights of servicemembers. This concern is driven (in part) by the intuition reflected in Judge O’Connor’s opening sentences—those sworn to protect constitutional liberties should surely enjoy the benefits of that which they protect. On the other, individual rights protections must yield, to some degree, to the needs of military life and military exigency. Of course, "to some degree" is the space in which debate and maneuverability resides. But while discretionary space certainly …


2022 Fall Engr333 Poster, Section A, Dat Cao, Izuchi Ebeku, Samuel Hoover, Sawyer Masselink, Ian Vanderkooi, Matthew Carlson, Jacob Heeres, Anthony Nykamp, Jacob Vanwyngarden, Nate Anderson, Anna Giboney, Gia Mien Le, Jonathan Washburn, Jess Camp, Ryan Macintyre, Aubree Peters, Alin Stoica, Drew Stoneburner, Claire Sheppard, Alayna Spiering, Reid Veneman, James Viel Dec 2022

2022 Fall Engr333 Poster, Section A, Dat Cao, Izuchi Ebeku, Samuel Hoover, Sawyer Masselink, Ian Vanderkooi, Matthew Carlson, Jacob Heeres, Anthony Nykamp, Jacob Vanwyngarden, Nate Anderson, Anna Giboney, Gia Mien Le, Jonathan Washburn, Jess Camp, Ryan Macintyre, Aubree Peters, Alin Stoica, Drew Stoneburner, Claire Sheppard, Alayna Spiering, Reid Veneman, James Viel

ENGR 333

In 2017 President Michael K. Le Roy signed Second Nature’s President Climate Commitment. This commitment outlines that Calvin’s governing body will ensure Calvin University is a carbon neutral educational institution by 2057. In June of 2022, Calvin University’s presidential seat was passed from Dr. Michael K. Le Roy to Dr. Wiebe Boer. In his short time as the president of Calvin University, Dr. Boer has put many projects into motion to help Calvin achieve its goal of becoming carbon neutral by 2057. This past fall Dr. Boer tasked the ENGR 333 class with answering the following question: What would it …


Functional Analysis Of Legionella Pneumophila Effector Protein, Shreya Neupane Dec 2022

Functional Analysis Of Legionella Pneumophila Effector Protein, Shreya Neupane

Masters Theses & Specialist Projects

Legionella pneumophila is a gram-negative bacterium that causes Legionnaire’s disease (a severe form of pneumonia) in humans. L. pneumophila can cause infection by utilizing its Type IV secretion system, a protein secretion system that transports proteins from the bacterial cytosol into the infected macrophage. Effectors released from the Type Iv secretion system allow L. pneumophila to create a safe environment to survive, replicate and cause infection. One such effector, RavQ, inhibits cell proliferation of mammalian HEK 293T cells and localizes to the cell’s nucleus, leading us to hypothesize that RavQ interferes with cellular activity in the nucleus. To detect its …


Improving Stakeholder Involvement In High Schools Using Community-Based Student Internships And Student Information Systems, Richard Lee Dooley Dec 2022

Improving Stakeholder Involvement In High Schools Using Community-Based Student Internships And Student Information Systems, Richard Lee Dooley

Masters Theses & Specialist Projects

Stakeholder involvement in education, according to literature, has been shown to decrease steadily as students progress from elementary to high school. Stakeholder involvement in this study included community involvement in the form of community advisory councils to assist in increasing the number of secondary students’ internship experiences available for a small, rural high school made up of approximately 300 students. Stakeholder involvement also included increasing parental involvement using technology in the form of student information systems and access to parents and students via smartphone apps and computer access.

This improvement science, mixed-methods project included two iterations of interventions aimed at …


Post Pandemic Cyberbiosecurity Threats From Terrorist Groups, Haley D. Dodge Dec 2022

Post Pandemic Cyberbiosecurity Threats From Terrorist Groups, Haley D. Dodge

Master's Theses

The research in this thesis explored the research question: Are United States (US) health systems accessible to cyber-bio terrorist attacks post-pandemic, within the context of the emerging discipline of cyberbiosecurity? Key findings of the analysis demonstrated how US health systems are more accessible to cyber-bio terrorist attacks specifically from cyber hacking groups based on the increasing sophistication of their cyber capabilities and the lack of cyber protection for biological systems. The concept of cyberbiosecurity was first introduced in 2018 by researchers exploring the converging threat landscape of the cyber and biology domains. As biology is growing more dependent upon vulnerable …


Research Note: Association Of Single Nucleotide Polymorphism Of Akt3 With Egg Production Traits In White Muscovy Ducks (Cairina Moschata)., Semiu Folaniyi Bello, Haiping Xu, Kan Li, Lijin Guo, Siyu Zhang, Ridwan Olawale Ahmed, Endashaw Jebessa Bekele, Ming Zheng, Mingjian Xian, Bahareldin Ali Abdalla, Adeniyi Charles Adeola, Adeyinka Abiola Adetula, Raman Akinyanju Lawal, Weijian Zhu, Dexiang Zhang, Xiquan Zhang, Congliang Ji, Qinghua Nie Dec 2022

Research Note: Association Of Single Nucleotide Polymorphism Of Akt3 With Egg Production Traits In White Muscovy Ducks (Cairina Moschata)., Semiu Folaniyi Bello, Haiping Xu, Kan Li, Lijin Guo, Siyu Zhang, Ridwan Olawale Ahmed, Endashaw Jebessa Bekele, Ming Zheng, Mingjian Xian, Bahareldin Ali Abdalla, Adeniyi Charles Adeola, Adeyinka Abiola Adetula, Raman Akinyanju Lawal, Weijian Zhu, Dexiang Zhang, Xiquan Zhang, Congliang Ji, Qinghua Nie

Faculty Research 2022

Prior studies on transcriptomes of hypothalamus and ovary revealed that AKT3 is one of the candidate genes that might affect egg production in White Muscovy ducks. The role of AKT3 in the uterus during reproductive processes cannot be overemphasized. However, functional role of this gene in the tissues and on egg production traits of Muscovy ducks remains unknown. To identify the relationship between AKT3 and egg production traits in ducks, relative expression profile was first examined prior to identifying the variants within AKT3 that may underscore egg production traits [age at first egg (AFE), number of eggs at 300 d …


A Reference Human Induced Pluripotent Stem Cell Line For Large-Scale Collaborative Studies., Caroline B Pantazis, Andrian Yang, Erika Lara, Justin A Mcdonough, Cornelis Blauwendraat, Lirong Peng, Hideyuki Oguro, Jitendra Kanaujiya, Jizhong Zou, David Sebesta, Gretchen Pratt, Erin Cross, Jeffrey Blockwick, Philip Buxton, Lauren Kinner-Bibeau, Constance Medura, Christopher Tompkins, Stephen Hughes, Marianita Santiana, Faraz Faghri, Mike A Nalls, Daniel Vitale, Shannon Ballard, Yue A Qi, Daniel M Ramos, Kailyn M Anderson, Julia Stadler, Priyanka Narayan, Jason Papademetriou, Luke Reilly, Matthew P Nelson, Sanya Aggarwal, Leah U Rosen, Peter Kirwan, Venkat Pisupati, Steven L Coon, Sonja W Scholz, Theresa Priebe, Miriam Öttl, Jian Dong, Marieke Meijer, Lara J M Janssen, Vanessa S Lourenco, Rik Van Der Kant, Dennis Crusius, Dominik Paquet, Ana-Caroline Raulin, Guojun Bu, Aaron Held, Brian J Wainger, Rebecca M C Gabriele, Jackie M Casey, Selina Wray, Dad Abu-Bonsrah, Clare L Parish, Melinda S Beccari, Don W Cleveland, Emmy Li, Indigo V L Rose, Martin Kampmann, Carles Calatayud Aristoy, Patrik Verstreken, Laurin Heinrich, Max Y Chen, Birgitt Schüle, Dan Dou, Erika L F Holzbaur, Maria Clara Zanellati, Richa Basundra, Mohanish Deshmukh, Sarah Cohen, Richa Khanna, Malavika Raman, Zachary S Nevin, Madeline Matia, Jonas Van Lent, Vincent Timmerman, Bruce R Conklin, Katherine Johnson Chase, Ke Zhang, Salome Funes, Daryl A Bosco, Lena Erlebach, Marc Welzer, Deborah Kronenberg-Versteeg, Guochang Lyu, Ernest Arenas, Elena Coccia, Lily Sarrafha, Tim Ahfeldt, John C Marioni, William C Skarnes, Mark R Cookson, Michael E Ward, Florian T Merkle Dec 2022

A Reference Human Induced Pluripotent Stem Cell Line For Large-Scale Collaborative Studies., Caroline B Pantazis, Andrian Yang, Erika Lara, Justin A Mcdonough, Cornelis Blauwendraat, Lirong Peng, Hideyuki Oguro, Jitendra Kanaujiya, Jizhong Zou, David Sebesta, Gretchen Pratt, Erin Cross, Jeffrey Blockwick, Philip Buxton, Lauren Kinner-Bibeau, Constance Medura, Christopher Tompkins, Stephen Hughes, Marianita Santiana, Faraz Faghri, Mike A Nalls, Daniel Vitale, Shannon Ballard, Yue A Qi, Daniel M Ramos, Kailyn M Anderson, Julia Stadler, Priyanka Narayan, Jason Papademetriou, Luke Reilly, Matthew P Nelson, Sanya Aggarwal, Leah U Rosen, Peter Kirwan, Venkat Pisupati, Steven L Coon, Sonja W Scholz, Theresa Priebe, Miriam Öttl, Jian Dong, Marieke Meijer, Lara J M Janssen, Vanessa S Lourenco, Rik Van Der Kant, Dennis Crusius, Dominik Paquet, Ana-Caroline Raulin, Guojun Bu, Aaron Held, Brian J Wainger, Rebecca M C Gabriele, Jackie M Casey, Selina Wray, Dad Abu-Bonsrah, Clare L Parish, Melinda S Beccari, Don W Cleveland, Emmy Li, Indigo V L Rose, Martin Kampmann, Carles Calatayud Aristoy, Patrik Verstreken, Laurin Heinrich, Max Y Chen, Birgitt Schüle, Dan Dou, Erika L F Holzbaur, Maria Clara Zanellati, Richa Basundra, Mohanish Deshmukh, Sarah Cohen, Richa Khanna, Malavika Raman, Zachary S Nevin, Madeline Matia, Jonas Van Lent, Vincent Timmerman, Bruce R Conklin, Katherine Johnson Chase, Ke Zhang, Salome Funes, Daryl A Bosco, Lena Erlebach, Marc Welzer, Deborah Kronenberg-Versteeg, Guochang Lyu, Ernest Arenas, Elena Coccia, Lily Sarrafha, Tim Ahfeldt, John C Marioni, William C Skarnes, Mark R Cookson, Michael E Ward, Florian T Merkle

Faculty Research 2022

Human induced pluripotent stem cell (iPSC) lines are a powerful tool for studying development and disease, but the considerable phenotypic variation between lines makes it challenging to replicate key findings and integrate data across research groups. To address this issue, we sub-cloned candidate human iPSC lines and deeply characterized their genetic properties using whole genome sequencing, their genomic stability upon CRISPR-Cas9-based gene editing, and their phenotypic properties including differentiation to commonly used cell types. These studies identified KOLF2.1J as an all-around well-performing iPSC line. We then shared KOLF2.1J with groups around the world who tested its performance in head-to-head comparisons …


Identifying Susceptibility Genes For Essential Hypertension By Transcriptome-Wide Association Study., Lu-Jie Huang, Qiao-Xia Zhang, Robert K Valenzuela, Jia-Chen Xu, Fang Yan, Jie Ma Dec 2022

Identifying Susceptibility Genes For Essential Hypertension By Transcriptome-Wide Association Study., Lu-Jie Huang, Qiao-Xia Zhang, Robert K Valenzuela, Jia-Chen Xu, Fang Yan, Jie Ma

Faculty Research 2022

Hypertension is a leading risk factor of cardiovascular disease and mortality in the population worldwide. Recently, hundreds of genomic loci were reported for hypertension by GWAS, however, the most SNPs are located in intergenic regions of genome, where a functional cause is difficult to determine. In the current study, a TWAS of hypertension was conducted using 452,264 individuals including 84,640 patients. KEGG and GO enrichment analyses were performed for the hypertension-related genes identified via TWAS. PPI network analysis based on the STRING database was also performed to detect TWAS-identified genes in hypertension. We have identified 18,420 genes from the …