Digital Commons Network^™

Descriptive Dna Barcoding Of Argas (Persicargas) Arboreus And Argas (Persicargas) Persicus Ticks (Ixodida: Argasidae) Infesting Birds In Egypt, Enas H. Ghallab, Ayat Yousery, Mona G. Shaalan

Harold W. Manter Laboratory of Parasitology: Library Materials

Argas ticks are primary parasites of birds with veterinary importance. Nevertheless, these ticks have received little attention regarding molecular identification studies. DNA barcoding is a powerful technique for identifying tick species besides traditional morphological identification. The present work is a first effort to divulge DNA sequences of Argas (Persicargas) arboreus from Egypt and worldwide. We used cytochrome c oxidase subunit I (COI) from A. arboreus infesting herons, and from the fowl tick Argas (Persicargas) persicus. Our results pointed out another success for the Folmer primers that are widely used in DNA barcoding, permitting the discrimination …

Addressing The Stigma Associated With Antiquated Blood Donation Policies And Donor Eligibility For Msm, Jay S. Pickern, Helena R. Costakis

Journal of the Georgia Public Health Association

The crises of blood product shortages pose real health risks and threats to the greater population in the United States (U.S.). Current U.S. blood donation policies continue to restrict or limit donations from willing and healthy individuals on the basis of sex, classified as men who have sex with men (MSM). This essay explores the historical progression of the current blood donation policy through the lens of enacted stigmatization and stigma consciousness for MSM, identifies implications of the current policy, explores the impact of the current policy and proposed changes, and calls for action to modernize the current blood donation …

Facilitating Employee Recovery From Work: The Role Of Leader‑Member‑Exchange, Judith Volmer, Eva-Maria Schulte, Charlotte Fritz

Psychology Faculty Publications and Presentations

Building on Affective Events Theory (AET), this study examined within-person relationships between employee perceptions of day-level leader-member exchange (LMX) and day-level positive affect as well as between positive affect and recovery from work in the evening (i.e., relaxation, mastery, control, and psychological detachment from work). In addition, LMX variability was examined as a moderator of these within-person relationships. Employees (N = 160) completed surveys at the end of the workday and in the evening across five consecutive workdays. Results indicate direct relationships between perceptions of LMX and employee positive affect at work. In addition, positive affect was positively associated …

Racial Disparities In Physician And Non-Physician Health Professionals: Investigating Barriers For Pre-Professional Students, Emily Remer

Honors Projects

“Diversity” is a buzzword across today’s educational, professional, and office settings. With so many looking to “diversify” their fields, it is important to note the endless ways in which people are diverse. From culture to religion to age to gender to race, and the intersectionality of them all, there has been a push to increase diversity as a means to better serve individuals in minority groups. While all forms of diversity are important, as is their intersectionality, the purpose of this project is to focus on racial disparities. There is no question that racial disparities exist across many roles we …

Remote Patient Monitoring: Decrease Rehospitalization For Spinal Cord Injury Patients, Abegail Cabunoc-Garcia

Student Scholarly Projects

Practice Problem: The lengthy distance required to access specialty care, the overall higher cost of SCI/D care, complications associated with SCI, and the potential negative impact of shortened hospital stays are all compelling reasons to use telehealth technologies to deliver specialty services for medical issues.

PICOT: The PICOT question that guided this project was in adult spinal cord injury patients with chronic disease receiving primary care at a spinal cord injury center (P), how does the implementation of a remote patient monitoring home telehealth for SCI patients recently discharged from acute-care setting (I) compared to the usual practice …

Program: Echoes Through Time, University Of Dayton

Dance and Theater Programs

Music by Caitlyn Hood

Dec. 2, 2022

Boll Theatre in Kennedy Union

Co-produced by the Theatre, Dance, and Performance Technology program and the Department of Music

We embarked on the Echoes Through Time journey with the intention to allow the student ensemble to learn about the life of Paul Laurence Dunbar through the creation of an original theatre performance with music selections. This show was devised from the students’ exploration of his life and legacy and the incorporation of music that put poetry to song. As directors, we were particularly taken with how the women in Dunbar’s life were compelling …

Biomarker, Treatment, And Socio-Demographic Factors Affecting Opioid Use Disorder Treatment Retention, Fernand A. De Los Reyes

Dissertations

Increasing mortality from opioid overdose and low treatment engagement are significant public health concerns. Along with increasing health care and criminal justice enforcement costs, there is an urgent need to study the factors associated with treatment retention in opioid use disorder. The study investigated the relative impact of the biomarker cholesterol on treatment retention in an opioid treatment program (OTP) clinic. Further, it examined the medical comorbidities, treatment, and socio-demographic variables that impact opioid use disorder treatment retention. This study was a secondary analysis of patient health records (n=267) in an opioid treatment program clinic. The study employed a hierarchical …

Factors Associated With New Hospital Nurses' Self-Efficacy In Providing Palliative End-Of-Life Care, Penny Marie Briese

Dissertations

Self-efficacy is defined as confidence in one's competence; the ability to successfully accomplish tasks and achieve favorable outcomes (Bandura, 1997). Many nurses today say they feel their undergraduate education was inadequate for them to feel competent to provide palliative and EOL patient care. (Chiplaskey, 2016; Scherlin & Quinn, 2016; Zheng et al., 2018).). Inadequate EOL preparation also results in nurses experiencing distress, death anxiety, burnout, feeling overwhelmed and leaving practice within just a few years (Friedman et al., 2011; Gaw, 2012; Kovner et al., 2006; Parry, 2008; Silverstein, 2017, November 28; Suzuki et al., 2008; Wilson & Kirshbaum, 2013). This …

Needs Assessment And Mentor Program Development For Sinclair School Of Nursing, Mindy Thompson

DNP and Student Works

An estimated 1.13 million new registered nurses are needed to fill new jobs and replace retiring nurses from 2012-2022. However, the nurse faculty shortage is a primary barrier to expanding the nursing workforce over the next decade. Nurses moving from the clinical setting to the academic setting need preparation, professional growth, and the development of a social network to make the transition a lasting one. Not only do mentoring relationships improve the work environment, but there is also an indication that it improves organizational commitment by achieving a sense of accomplishment, autonomy in their role, support for professional growth, and …

Human Papillomavirus Vaccine Administration Trends Among Commercially Insured Us Adults Aged 27-45 Years Before And After Advisory Committee On Immunization Practices Recommendation Change, 2007-2020, Ryan Suk, Kaiping Liao, Cici X Bauer, Catherine Basil, Meng Li

Faculty, Staff and Student Publications

IMPORTANCE: In 2019, the Advisory Committee on Immunization Practices (ACIP) recommended patient-clinician shared decision-making for human papillomavirus (HPV) vaccination in adults aged 27 to 45 years. Less is known about the HPV vaccine administration trends in this age group before and after this recommendation update.

OBJECTIVE: to examine the association between the ACIP recommendation update and the HPV vaccine administration among US adults aged 27 to 45 years.

DESIGN, SETTING, AND PARTICIPANTS: This large commercial claim-based retrospective cohort study used the Optum Clinformatics database for validated claims from January 1, 2007, through December 31, 2020. A total of 22 600 …

Sustained Aurora Kinase B Expression Confers Resistance To Pi3k Inhibition In Head And Neck Squamous Cell Carcinoma, Pooja A Shah, Vaishnavi Sambandam, Anne M Fernandez, Hongyun Zhao, Tuhina Mazumdar, Li Shen, Qi Wang, Kazi M Ahmed, Soma Ghosh, Mitchell J Frederick, Jing Wang, Faye M Johnson

Faculty, Staff and Student Publications

UNLABELLED: Tumor suppressor mutations in head and neck squamous cell carcinoma (HNSCC) dominate the genomic landscape, hindering the development of effective targeted therapies. Truncating and missense mutations in NOTCH1 are frequent in HNSCC, and inhibition of PI3K can selectively target NOTCH1 mutant (NOTCH1MUT) HNSCC cells. In this study, we identify several proteins that are differentially regulated in HNSCC cells after PI3K inhibition based on NOTCH1MUT status. Expression of Aurora kinase B (Aurora B), AKT, and PDK1 following PI3K inhibition was significantly lower in NOTCH1MUT cell lines than in wild-type NOTCH1 (NOTCH1WT) cells or NOTCH1MUT cells with acquired resistance to PI3K …

Medical Monitoring Working Group Meeting Minutes, Mike Mcanulty

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

2022 Draft Final Blacktail Creek Groundwater Hydraulic Control System Remedial Design Work Plan, Stantec Consulting Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

2022 Draft Final Blacktail Creek Groundwater Hydraulic Control System Remedial Design Work Plan, Stantec Consulting Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

African American Family Members’ Needs And Experiences During A Loved One’S End-Of-Life, Kelley Obringer

Theses and Dissertations

This study aimed to explore African American family members’ needs and experiences during their loved one’s end-of-life. In Chapter 1, a literature review was conducted to review the current state of the literature regarding African American family members’ needs and experiences during their loved one’s end-of-life. Chapter 2 includes a qualitative exploratory study of African American family members’ needs and experiences during their loved one’s end-of-life. The study sample consisted of family members of African Americans being cared for through services provided by an outpatient palliative care facility in the Southeastern United States. Family members answered five open-ended interview questions …

The Future Of Our Economy ‐ Part Ii, Ishrat Husain Dr.

Faculty Research - Newspaper and Magazine Articles

The short-term measures described in Part I will not have the desired effects unless the emphasis is shifted in our school system towards Science, Technology, Engineering, Creative Arts and Mathematics (STEAM) subjects. Focus on these subjects along with content, hardware, network, software application, choices of pedagogical tools and so on all has to be entrusted to private service providers (PSP) under performance-linked contractual agreements. The setting up of computer labs, local area networks, data centres etc would require a massive jump in the allocation of budgetary resources towards education. But this would be a worthwhile use of our scarce resources …

A Time And Place For Inhibiting Autophagy, Boyi Gan

Faculty, Staff and Student Publications

Autophagy is an attractive therapeutic target in cancer. Successful autophagy-focused clinical intervention will require a detailed understanding of when and where autophagy is important during tumorigenesis. In this issue of Cancer Research, Khayati and colleagues use state-of-the-art genetically engineered mouse models to demonstrate that transient systemic inhibition of autophagy can irreversibly impair the growth of established lung tumors with a good tolerability in normal tissues, suggesting a therapeutic strategy for cancer treatment.

Treatment Of Epilepsy Using A Targeted P38Γ Kinase Gene Therapy, Nicolle Morey, Magdalena Przybyla, Julia Van Der Hoven, Yazi D Ke, Fabien Delerue, Janet Van Eersel, Lars M Ittner

Faculty, Staff and Student Publications

Hyperphosphorylated microtubule-associated protein tau has been implicated in dementia, epilepsy, and other neurological disorders. In contrast, site-specific phosphorylation of tau at threonine 205 (T205) by the kinase p38γ was shown to disengage tau from toxic pathways, serving a neuroprotective function in Alzheimer's disease. Using a viral-mediated gene delivery approach in different mouse models of epilepsy, we show that p38γ activity-enhancing treatment reduces seizure susceptibility, restores neuronal firing patterns, reduces behavioral deficits, and ameliorates epilepsy-induced deaths. Furthermore, we show that p38γ-mediated phosphorylation of tau at T205 is essential for this protection in epilepsy, as a lack of this critical interaction reinstates …

Who Has The Right To Pull The Plug?, Laila El Baradei

Faculty Journal Articles

No abstract provided.

Georgia Southern University Fact Book, Georgia Southern University

Georgia Southern Fact Books (1976-2022)

No abstract provided.

Hyperkalemia And Electrocardiogram Manifestations In End-Stage Renal Disease, Zubaid Rafique, Bryan Hoang, Heba Mesbah, Ryan Pappal, Frank W Peacock, Raul Juarez-Vela, Lukasz Szarpak, Dick C Kuo

Faculty, Staff and Students Publications

Hyperkalemia is one of the more common acute life-threatening metabolic emergencies. The aim of our study is to determine the correlation and accuracy of abnormal ECG parameters as a function of serum potassium concentration in the end-stage renal disease (ESRD) population. We performed a retrospective chart review of emergency department patients presenting with ESRD and receiving emergent hemodialysis treatment. A total of 96 patients, each with five independent ED visits, provided 480 sets of ECGs and electrolytes. Of these, four ECGs were excluded for inability to interpret, leaving a total of 476 patient encounters that met all inclusion criteria. Linear …

Association Of Maternal Age 35 Years And Over And Prenatal Care Utilization, Preterm Birth, And Low Birth Weight, Mexico 2008–2019, Laura Jacobson, Evelyn Fuentes-Rivera, Raffaela Schiavon, Blair Darney

OHSU-PSU School of Public Health Faculty Publications and Presentations

Objective:

We compared prenatal care utilization, preterm birth, and low birth weight neonates among women 35 years and older compared to women 20-34 years old in Mexico, 2008-2019.

Methods:

We used birth certificate data and conducted a historical cohort study of all singleton live births in Mexico from 2008-2019. Study outcomes were inadequate prenatal care (timing of initiation of care and number of visits), preterm birth, and low birth weight. We compared outcomes among women 35-39, 40-44, and 45-49 with births to women 20-34. We used logistic regression to account for individual and contextual confounders.

Results:

We included a total …

Sitting Time And Insulin Resistance In 6,931 United States Adults: The Role Of Abdominal Adiposity, Kayla Marie Parker

Theses and Dissertations

This cross-sectional investigation of 6,931 U.S. adults examined the relationship between sitting time and insulin resistance. A primary objective was to evaluate how this relationship was mediated by the following variables: age, sex, race, year of assessment, cigarette smoking, physical activity, body mass index (BMI), and waist circumference. Self-reported sitting time, measured in minutes per day, was the exposure variable. Insulin resistance, indexed by the homeostatic model assessment of insulin resistance (HOMA-IR), was the outcome variable. Data were used from the 2011-2018 National Health and Nutrition Examination Survey (NHANES). Results showed a strong, positive association between sitting time and insulin …

Active Dna Demethylation Promotes Cell Fate Specification And The Dna Damage Response, Dongpeng Wang, Wei Wu, Elsa Callen, Raphael Pavani, Nicholas Zolnerowich, Srikanth Kodali, Dali Zong, Nancy Wong, Santiago Noriega, William J Nathan, Gabriel Matos-Rodrigues, Raj Chari, Michael J Kruhlak, Ferenc Livak, Michael Ward, Keith Caldecott, Bruno Di Stefano, André Nussenzweig

Faculty, Staff and Students Publications

Neurons harbor high levels of single-strand DNA breaks (SSBs) that are targeted to neuronal enhancers, but the source of this endogenous damage remains unclear. Using two systems of postmitotic lineage specification-induced pluripotent stem cell-derived neurons and transdifferentiated macrophages-we show that thymidine DNA glycosylase (TDG)-driven excision of methylcytosines oxidized with ten-eleven translocation enzymes (TET) is a source of SSBs. Although macrophage differentiation favors short-patch base excision repair to fill in single-nucleotide gaps, neurons also frequently use the long-patch subpathway. Disrupting this gap-filling process using anti-neoplastic cytosine analogs triggers a DNA damage response and neuronal cell death, which is dependent on TDG. …

Dietary Intakes Of Folate, Vitamin D And Iodine During The First Trimester Of Pregnancy And The Association Between Supplement Use And Demographic Characteristics Amongst White Caucasian Women Living With Obesity In The Uk, Kathy M. Redfern, Heidi J. Hollands, C. Ross Welch, Jonathan H. Pinkney, Gail A. Rees

School of Biomedical Sciences

Folate, vitamin D and iodine are key micronutrients in pregnancy, with deficiency associated with poor maternal and infant outcomes. For folate and vitamin D especially, deficiency is more common amongst women with obesity and recommended intakes and guidance on supplementation varies worldwide. The present study aims to investigate dietary and supplementary intakes of these micronutrients amongst a population of pregnant women with obesity in the United Kingdom, alongside key maternal demographic characteristics. Expectant women (n = 75) with a body mass index ≥ 30 kg/m2 at first antenatal appointment were recruited at 12 weeks gestation. Participants were asked about their …

Equity Implications Of Hospital Penalties During 4 Years Of The Comprehensive Care For Joint Replacement Model, 2016 To 2019, Sukruth A Shashikumar, Andrew M Ryan, Karen E Joynt Maddox

2020-Current year OA Pubs

No abstract provided.

Genome-Edited Zebrafish Model Of Abcc8 Loss-Of-Function Disease, Jennifer M Ikle, Robert C Tryon, Soma S Singareddy, Nathaniel W York, Maria S Remedi, Colin G Nichols

2020-Current year OA Pubs

ATP-sensitive potassium channel (K

Distinct Tumor Necrosis Factor Alpha Receptors Dictate Stem Cell Fitness Versus Lineage Output In Dnmt3a-Mutant Clonal Hematopoiesis, Jennifer M Sanmiguel, Elizabeth Eudy, Matthew A Loberg, Kira A Young, Jayna J Mistry, Kristina D Mujica, Logan S Schwartz, Timothy M Stearns, Grant A Challen, Jennifer J Trowbridge

2020-Current year OA Pubs

UNLABELLED: Clonal hematopoiesis resulting from the enhanced fitness of mutant hematopoietic stem cells (HSC) associates with both favorable and unfavorable health outcomes related to the types of mature mutant blood cells produced, but how this lineage output is regulated is unclear. Using a mouse model of a clonal hematopoiesis-associated mutation, DNMT3AR882/+ (Dnmt3aR878H/+), we found that aging-induced TNFα signaling promoted the selective advantage of mutant HSCs and stimulated the production of mutant B lymphoid cells. The genetic loss of the TNFα receptor TNFR1 ablated the selective advantage of mutant HSCs without altering their lineage output, whereas the loss of TNFR2 resulted …

Identification Of Novel Antifungal Skeleton Of Hydroxyethyl Naphthalimides With Synergistic Potential For Chemical And Dynamic Treatments, Pengli Zhang, Vijai Kumar Reddy Tangadanchu, Chenghe Zhou

2020-Current year OA Pubs

The invasion of pathogenic fungi poses nonnegligible threats to the human health and agricultural industry. This work exploited a family of hydroxyethyl naphthalimides as novel antifungal species with synergistic potential of chemical and dynamic treatment to combat the fungal resistance. These prepared naphthalimides showed better antifungal potency than fluconazole towards some tested fungi including

Hyperkalemia And Electrocardiogram Manifestations In End-Stage Renal Disease, Zubaid Rafique, Bryan Hoang, Heba Mesbah, Ryan Pappal, Frank W Peacock, Raul Juarez-Vela, Lukasz Szarpak, Dick C Kuo

2020-Current year OA Pubs

Hyperkalemia is one of the more common acute life-threatening metabolic emergencies. The aim of our study is to determine the correlation and accuracy of abnormal ECG parameters as a function of serum potassium concentration in the end-stage renal disease (ESRD) population. We performed a retrospective chart review of emergency department patients presenting with ESRD and receiving emergent hemodialysis treatment. A total of 96 patients, each with five independent ED visits, provided 480 sets of ECGs and electrolytes. Of these, four ECGs were excluded for inability to interpret, leaving a total of 476 patient encounters that met all inclusion criteria. Linear …