Digital Commons Network^™

Evaluation Of Antimicrobial Prophylaxis In Spine Surgery Within An Enhanced Recovery Program At A Large Community Teaching Hospital, Sabrina Dipietro, Klea Noskey, Richard Zoltowski, Tania Saeed, Sapna Shah

Posters

The risk of surgical site infections post spine surgery is 0% to 18%.1

• American Society of Health System Pharmacists (ASHP) and Enhanced Recovery After Surgery (ERAS) Society guidelines recommend using an agent with activity against the most common surgical site pathogens including Staphylococcus aureus. 2,3

• The preferred agent is cefazolin 2 grams intravenous (IV) (3 grams if patient weighs ≥120 kilograms [kg]) administered 30 minutes prior to skin incision and re-dosed every four hours intraoperatively.2,3

• In the case of a cephalosporin allergy, clindamycin 900 milligrams (mg) IV or vancomycin 15 mg/kg IV are recommended alternatives.2,3

• Due …

Pharmacist-Provided Educational Intervention And Its Impact On Medical Resident Knowledge And Comfort Level With Continuous Glucose Monitors (Cgms), Chelsea Dezfuli, Sarah Muench, Colleen Lauster

Posters

Continuous glucose monitors (CGMs) have become an integral component of diabetes care

American Diabetes Association now recommends that CGMs be offered to all patients on insulin who can use the device safely

Integrating CGMs into clinical practice can be challenging for several reasons: – Data overload – Cost – Need for education on data interpretation

Safety Evaluation Of Intravenous Heparin Protocol Following Alteplase Treatment In Patients With Suspected Or Confirmed Pulmonary Embolism, Erika Waldsmith, Lisa Hall Zimmerman, Claudia Hanni

Posters

No abstract provided.

Evaluation Of Safety Outcomes Of Two Hydrocortisone Dosing Regimens In Patients In Septic Shock, Alexandra Rola, Joshua Wirtz, Daniel Kalaj, Vasil Rrushi, Megan Cadiz

Posters

• Steroids are used in shock to minimize the impact of shock-induced dysregulation of inflammatory response – Hydrocortisone is preferred for its activity as a glucocorticoid and a mineralocorticoid • Available data on the use of hydrocortisone shows mixed benefit – Data to guide dosing is limited, use of 100 mg IV every 8 hours may have benefit over 50 mg IV every 6 hours • Use of steroids has been associated with potential risks, including gastrointestinal bleeding, hyperglycemia, hypernatremia, superinfection, etc.

Ertapenem Versus Meropenem For The Treatment Of Esbl-Producing Enterobacterales Bacteremia In Critically Ill Patients, Sydney Vandorf, Prakash Shah, Chad Richardson, Christine Yost

Posters

The purpose of this study is to evaluate clinical outcomes for critically ill patients receiving ertapenem or meropenem for ESBL-producing Enterobacterales bacteremia.

Impact Of Continuous Infusion Ketamine As Sedation On Concomitant Opioid And Sedative Requirements In Mechanically Ventilated Covid-19 Patients, Gabrielle R. Bradley, Megan Cadiz, Allycia Natavio

Posters

Characterize the impact of continuous infusion ketamine (CIK) on concomitant opioid and sedative requirements in mechanically ventilated COVID-19 patients

Levetiracetam For Seizure Prophylaxis In Spontaneous Intracerebral Hemorrhage, Alanah Bratley, Krystal Commons, Allycia Natavio

Posters

Characterize the use of levetiracetam for early seizure prophylaxis in patients with sICH

Lower-Income Countries’ Ongoing Quest For International Tax Justice: A Case Study Of The Oecd’S Tax Allocation Proposal, Okanga Ogbu Okanga, Kim Brooks

Articles, Book Chapters, & Popular Press

The viability of our international tax system hinges on two things: (1) safeguarding the effective flow of international activities and (2) ensuring that countries can adequately collect tax on the income derived from those activities. Each of these fundamentals relies on a defensible/fair allocation of taxing rights between countries with competing tax jurisdiction (inter-nation equity).

The recent Organisation for Economic Co-operation and Development (OECD)-led multilateral effort to transform international tax rules to ensure that countries can adequately tax multinational enterprises (MNEs) operating in the global digital economy (OECD proposal) has reignited inter-nation equity conversations. Although important to all countries, inter-nation …

Confederate Statues In University Opinion Newspaper Articles: An Analysis Of Themes And Attachment, Jamie Nicole Knopf

Dissertations and Theses

Many have asked for Confederate monuments' removal while others argue that they should remain or be recontextualized. Knopf analyzed themes found in Southern university student newspapers on the monument issue and how the statues related to community attachment. Using thematic analysis, Knopf identified six themes across the articles, and found that both removal and recontextualization arguments refer to the ideology behind the statues and the impacts this can have on students. Instances of attachment were used in both removal and recontextualization articles.

Use It Or Lose It: Impact Of Sepsis Order Set ​Utilization On The Severe Sepsis And Septic Shock Management Bundle Compliance, Alex Stabler, Ross Singletary, Shalyn Cox, Larry J Pineda

Articles, Abstracts, and Reports

No abstract provided.

Standardization Of A Latent Blood Visualizer Based Upon Dna Degradation, Kailey M. Van 'T Hoff

Honors Projects

Latent blood visualizers have been used in forensic science since 1937 beginning with Luminol. These visualizers through different types of reactions react with trace amounts of blood that cannot be seen with the naked human eye. These different reactions produce color that can then be seen by examiners. The four types of latent blood visualizers that were compared is luminol, leuco crystal violet, fluorescein, and bluestar. Luminol and bluestar use chemiluminescence, fluorescein uses florescent, and leuco crystal violet uses oxidation to react with iron in hemoglobin. At crime scenes when blood is detected which includes with the blood visualizers the …

12-06-22 Hsc Committee Meeting Minutes, Hsc Committee

HSC Committee (A subcommittee of the UNM Board of Regents)

No abstract provided.

Toxicity And Effectiveness Of A New Two-Part Underwater Adhesive For Coral Restoration, Matthew Rojano

All HCAS Student Capstones, Theses, and Dissertations

As coral cover decreases around the world due to disease, bleaching events, and anthropogenic effects, coral restoration projects become increasingly important. A crucial part of many coral restoration projects is the attachment of corals to substrates in nurseries or reef substrates during outplanting. The effective anchoring of transplants is a critical phase in coral restoration and the adhesive used for attachment is crucial. Commonly used adhesives have several drawbacks: there are long mixing times, low substrate adhesion, and lengthy hardening times. To address these issues and provide an effective alternative for coral restoration activities, a new two-part Mixed Adhesive was …

Amgen V. Sanofi: The Supreme Court Takes Up The Enablement Requirement In The Context Of Therapeutic Monoclonal Antibodies, Christopher M. Holman

Faculty Works

No abstract provided.

Center's Role Critical In Quality And Safety Of Supplements, Cosmetics, Erin Garrett

University of Mississippi News

NCNPR globally recognized for expertise in field of botanicals research

Evaluation Of Antibiotic Selection And Duration In Patients With Non-Severe Community Acquired Pneumonia, Emily Reich, Sandra Hartnagle, Jennifer Pilotto, Heidi Klotz, Ryan Herc

Posters

No abstract provided.

Body Image Dissatisfaction In Correlation With Self-Efficacy And Depression, Nate Burden

Student Works

This literature review focuses on the topic of body image dissatisfaction (BID) and self efficacy/esteem. I aimed to review the association between the two. Multiple databases were included, primarily utilizing terms such as “self-esteem” “Body image dissatisfaction” “depression” and “Self-efficacy”. Results review the various factors of body image dissatisfaction. These factors included aspects of appearance in various regions of the body, but primarily through weight and body shape. I reviewed the association and comparison of depression with body image dissatisfaction. The goal was in identifying the cause effect relationship between the two leading to the next part of the study. …

John Enlund, Oral History Interview, 2022, Victoria Buckman, Matt Jones

Oral Histories

In the Fall of 2022, Matt Jones’s Oral History Techniques class conducted a set of interviews documenting the stories behind the student unrest on Eastern Michigan University’s campus from 1966-1972. John Enlund was a dedicated student activist on EMU's campus, member of Students for a Democratic Society, and one of the students arrested at McKenny Hall on campus during the People's Lounge Incident. He was involved with others like Frank Michels and Barry Simon during this time of student unrest, and left his mark on EMU.

Cpg Site-Based Signature Predicts Survival Of Colorectal Cancer, Jiande Wu, Lu Zhang, Aditi Kuchi, David Otohinoyi, Chindo Hicks

School of Medicine Faculty Publications

Background: A critical unmet medical need in clinical management of colorectal cancer (CRC) pivots around lack of noninvasive and or minimally invasive techniques for early diagnosis and prognostic prediction of clinical outcomes. Because DNA methylation can capture the regulatory landscape of tumors and can be measured in body fluids, it provides unparalleled opportunities for the discovery of early diagnostic and prognostics markers predictive of clinical outcomes. Here we investigated use of DNA methylation for the discovery of potential clinically actionable diagnostic and prognostic markers for predicting survival in CRC. Methods: We analyzed DNA methylation patterns between tumor and control samples …

Notch Signaling Pathway: A Comprehensive Prognostic And Gene Expression Profile Analysis In Breast Cancer, Hassan Yousefi, Afshin Bahramy, Narges Zafari, Mahsa Rostamian Delavar, Khoa Nguyen, Atousa Haghi, Tahmineh Kandelouei, Cecilia Vittori, Parham Jazireian, Sajad Maleki, Danyal Imani, Amin Moshksar, Amirreza Bitaraf, Sadegh Babashah

School of Medicine Faculty Publications

Breast cancer is a complex disease exhibiting a great degree of heterogeneity due to different molecular subtypes. Notch signaling regulates the differentiation of breast epithelial cells during normal development and plays a crucial role in breast cancer progression through the abnormal expression of the Notch up-and down-stream effectors. To date, there are only a few patient-centered clinical studies using datasets characterizing the role of Notch signaling pathway regulators in breast cancer; thus, we investigate the role and functionality of these factors in different subtypes using publicly available databases containing records from large studies. High-throughput genomic data and clinical information extracted …

Overexpression Of Sox18 Increased Cell Proliferation, Migration And Colony Formation In Pediatric Sarcomas, Jack E. Ojile

Honors Program Theses and Research Projects

Cancer has become one of the leading causes for premature deaths and continues to increase in rank across the world. An estimated 19.3 million new cases of cancer were reported in 2020 and 10 million cancer related deaths occurred worldwide. Ewing sarcoma and Rhabdomyosarcoma are two pediatric cancers that have not made significant improvements to patient survival for a metastatic diagnosis and the current chemotherapy regiment can cause several undesirable side effects immediately after treatment or later in life. SOX18 has been observed to play some role in various tumorigenic properties like proliferation, invasion, and resisting cell death signals in …

Pre-Hospital Conditions Affecting The Hospitalization Risk In Older Adults At The Emergency Department, Karin Erwander, Kjell Ivarsson, Mona Landin-Olsson, Björn Agvall

Journal of Geriatric Emergency Medicine

BACKGROUND: The Emergency Department (ED) is a common route to hospitalization for critically ill and older adults. Older patients are admitted to hospital at a higher rate and have longer length of stay (LOS) when hospitalized. To be able to confront an increasing aging population, meet their medical needs and influence rising costs of health care, there is a need to focus on the older population. In Scandinavia, few studies are made that focus on the geriatric population at the ED. It is essential to early identify risk factors for hospitalization at the ED to improve the medical care for …

The Farriers’ Perspective Of Ergonomics, Hailey Harrington, Gwen Morris

Fall 2022 Virtual OTD Capstone Symposium

Farriers, or individuals who specialize in the shoeing of horses, navigate a variety of ergonomic challenges. Such challenges have the potential to severely impact their working ability and other major areas of their lives. Early research from Holler (1984) and King (2003) investigated farrier perceptions of hazardous job requirements and tool hazards in relations to strain on their bodies. Additional factors to consider include other external factors such as human and animal interactions, physiological, and psychological factors (Flunker et al., 2020; Gombeski et al., 2017).The purpose of this study is to learn about the ergonomic conditions of farriers and their …

The Swift Completion Of Their Appointed Rounds, Roger Michalski

Other Faculty Publications

No abstract provided.

Exploring Heuristics And Best Practices For Redesigning Instructional Video, Kelly L. Murdock

Theses and Dissertations

Instructional video is a common staple for delivering content in online courses. However, if the included videos are not properly created, many students will skip the video and its content. Improving instructional video has been the topic of many research projects, and we can learn from these studies how to create effective and engaging instructional videos--this is the topic of my dissertation. The first paper is an extended literature review that examines which key instructional design principles are supported in the literature. This helps developers to know which principles to focus on when designing video. The second paper is a …

Methods For Engineers To Understand, Predict, And Influence The Social Impacts Of Engineered Products, Phillip Douglas Stevenson

Theses and Dissertations

Engineered products can impact the day-to-day life of their users and other stakeholders. These impacts are often referred to as the product's social impacts. Products have been known to impact the people who use them, design them, manufacture them, distribute them, and the communities where they exist. Currently, there are few methods that can help an engineer identify, quantify, predict, or improve a product's social impact. Some companies and organizations have tried to identify their impacts and, for example, set goals for achieving more sustainable business practices. However, engineers, in large part, do not have methods that can help improve …

Targeting Tmem205 Mediated Drug Resistance In Ovarian Clear Cell Carcinoma Using Oncolytic Virus, Uksha Saini, Brentley Q Smith, Kalpana Deepa Priya Dorayappan, Ji Young Yoo, G Larry Maxwell, Balveen Kaur, Ikuo Konishi, David O'Malley, David E Cohn, Karuppaiyah Selvendiran

Faculty, Staff and Student Publications

BACKGROUND: Ovarian clear cell carcinoma (OCCC) accounts for approximately 8-10% of epithelial ovarian cancers in the United States. Although it is rare, OCCC usually presents with treatment challenges and the overall prognosis is far worse than high grade serous ovarian cancer HGSOC. The objective of this study was to examine the therapeutic relevance of combining oncolytic virus with cisplatin for ovarian cancer clear cell carcinoma (OCCC).

RESULTS: We identified that TMEM205, a recently discovered transmembrane protein, contributes to chemoresistance in OCCC cells via the exosomal pathway. Mechanistically, TMEM205 undergoes ligand-independent constitutive endocytosis and co-localizes with Rab11 to contribute to the …

A Gbd 2019 Study Of Health And Sustainable Development Goal Gains And Forecasts To 2030 In Spain, Jeffrey V Lazarus, Alberto Ortiz, Stefanos Tyrovolas, Esteve Fernández, Danielle Guy, Trenton M White, Rui Ma, Simon I Hay, Mohsen Naghavi, Joan B Soriano, Gbd 2019 Spain Collaborators

Faculty, Staff and Student Publications

This study aimed to report mortality, risk factors, and burden of diseases in Spain. The Global Burden of Disease, Injuries, and Risk Factors 2019 estimates the burden due to 369 diseases, injuries, and impairments and 87 risk factors and risk factor combinations. Here, we detail the updated Spain 1990-2019 burden of disease estimates and project certain metrics up to 2030. In 2019, leading causes of death were ischaemic heart disease, stroke, chronic obstructive pulmonary disease, Alzheimer's disease, and lung cancer. Main causes of disability adjusted life years (DALYs) were ischaemic heart disease, diabetes, lung cancer, low back pain, and stroke. …

Heavy Metals In Four Marine Fish And Shrimp Species From A Subtropical Coastal Area: Accumulation And Consumer Health Risk Assessment, Mohammad Belal Hossain, Nurer Zaman Bhuiyan, Abul Kasem, Md Kamal Hossain, Salma Sultana, As-Ad Ujjaman Nur, Jimmy Yu, Mohammed Fahad Albeshr, Takaomi Arai

Faculty, Staff and Student Publications

Trace-element or heavy-metal pollution has emerged as a serious concern in terms of both environmental and human health issues. This study measured six trace and toxic heavy metals (Pb, Cd, Cr, Ni, Cu, and Zn) in four marine fish and shrimp species to assess their accumulation levels and evaluate the risks to human health. The mean concentrations of the metals in fish and shrimp species (Labeo bata, Sillaginopsis panijus, Platycepalus fuscus, and Penaeus monodon) followed the decreasing order of Zn (40.8 ± 9.7 μg/g) > Cu (17.8 ± 7.1 μg/g) > Pb (6.2 ± 1.8 μg/g) > Ni (0.4 ± 0.3 μg/g) > Cd …

Gait Phase Estimation Of Unsupervised Outdoors Walking Using Imus And A Linear Regression Model, Ahmed Soliman, Guilherme A. Ribeiro, Andres Torres, Li-Fan Wu, Mo Rastgaar

Purdue University Libraries Open Access Publishing Fund

Human gait analysis and detection are critical for many applications, including wearable and rehabilitation robotic devices, reducing or tracking injury risk. The proposed work allows researchers to study the gait phase of human subjects in an unsupervised outdoor environment without the need for fixed thresholds and sensor-embedded insoles. We present an experimental protocol to label gait events based on patterns in human subjects from two body-worn inertial measurement units (IMUs). Gait patterns are developed using a force plate and a motion capture system. Upon defining the gait pattern, human subjects walk outdoors for forty minutes to train and test a …