Digital Commons Network^™

Classified: How Inequality Shapes The ‘Need To Know’ Question In Sex Education, Sarah Thornton

Theses and Dissertations

Schools are a critical site of socialization in which young people learn both formal curricular materials and informal lessons about social structure, agency, and inequality. This study examines the meaning making patterns of teachers and students in sex education classrooms and considers how these patterns reflect the structure and agency relationship between people and the institutions in which they are embedded. Through a series of interviews and using qualitative thematic analysis, I identify themes in how students and teachers discuss their experiences, how these themes relate to broader patterns of social hierarchy, and how sex education can act as a …

Development Of Alternative Air Filtration Materials And Methods Of Analysis, Ivan Philip Beckman

Theses and Dissertations

Clean air is a global health concern. Each year more than seven million people across the globe perish from breathing poor quality air. Development of high efficiency particulate air (HEPA) filters demonstrate an effort to mitigate dangerous aerosol hazards at the point of production. The nuclear power industry installs HEPA filters as a final line of containment of hazardous particles. Advancement air filtration technology is paramount to achieving global clean air. An exploration of analytical, experimental, computational, and machine learning models is presented in this dissertation to advance the science of air filtration technology. This dissertation studies, develops, and analyzes …

Combined Effects Of Cyclosporine And Prednisone On T-Cell Cytokine Production In Healthy Dogs, Brittany Moore-Henderson

Theses and Dissertations

Cyclosporine and prednisone are immunosuppressive drugs that are commonly used in combination for the treatment of immune-mediated diseases, and have been shown to individually cause significant suppression of IL-2. Currently, no studies have been performed to determine how a combination of the two drugs would impact suppression of IL-2, and if an additive or synergistic effect on cytokine production could be demonstrated, as in studies of other species. An additive effect of immunosuppression associated with this drug combination could allow clinicians to decrease dosages of drugs, thereby reducing drug costs and minimizing adverse drug side effects. In a cross-over study …

Analysis Of Process And Environmental Parameters Impacting Membrane Fouling, Methane Production, Soluble Microbial Products, Extracellular Polymeric Substances And Chemical Oxygen Demand Removal In Anaerobic Membrane Bioreactors Wastewater Treatment, James Mark-Ige

Theses and Dissertations

Aerobic (AeMBRs) and Anaerobic Membrane Bioreactors (AnMBRs) are an essential part of the advanced wastewater treatment options, which offer advantages in terms of higher effluent discharge and smaller footprints over the traditional wastewater treatment. This study evaluates the performance of (AnMBRs) by analyzing the cumulative effect of eleven physico-chemical parameters from the data obtained from the studies conducted from year 2000 onwards. Effect of various parameters such as Solid Retention Time (SRT), Hydraulic Retention Time (HRT), Mixed Liquor Suspended Solids (MLSS), influent Chemical Oxygen Demand (COD), Organic Loading Rate (OLR), influent COD, and temperature on the COD removal, methane production …

Unraveling The Anti-Inflammatory Mechanisms And Efficacy Of Cannabidiol On The Progression Of A Murine Model Of Multiple Sclerosis From The Innate To The Adaptive Immune System To Clinical Symptoms, Christa Marie Frodella

Theses and Dissertations

Cannabidiol (CBD), a non-psychotropic phytocannabinoid with structural similarity to Δ 9 -tetrahydrocannabinol (THC), is currently being investigated as a therapeutic for its immunosuppressive effects. One disease for which CBD is extensively researched is multiple sclerosis (MS), a demyelinating, autoimmune disorder, and its murine model counterpart, experimental autoimmune encephalomyelitis (EAE). The focus of this dissertation aimed to analyze the transcriptomic brain pathways in EAE and its comparison to MS in addition to CBD’s immunosuppressive mechanisms in the innate and adaptive immune systems. Evidence presented here showed that transcriptomic signaling pathways in the EAE brain of mice with clinical symptoms were similar …

Evaluation Of Soybean [Glycine Max (L.) Merr.] Cultivar Response To Prophylactic Fungicide Application, Steven B. Stoker

Theses and Dissertations

Soybean growers in the southern United States commonly deal with disease issues that can limit yield potential. As a result, growers have adopted prophylactic fungicide application targeted at specific growth stages as a standard management practice. However, yield responses to prophylactic applications have become sporadic over time. One major change that has occurred is adoption of cultivars with improved disease tolerances. Therefore, the objective of this research was to evaluate yield response of cultivars representing multiple genetic backgrounds to fungicides applied prophylactically at the R4 soybean growth stage. Experiments were conducted in 2020 and 2021 to determine the yield impact …

United We Stand? Investigating The Impact Of Unified Dues Agreements Between State And National Career & Technical Education (Cte) Professional Organizations On Cte Funding In The Southern States, Justin Ryan Hall

Theses and Dissertations

Career and Technical Education (CTE) teachers have long been active in lobbying the federal and state governments in support of CTE through their professional organizations, but these are not traditionally considered interest groups. This study sought to determine if the formal relationships—dues agreements—between the two largest national professional organizations, and their state affiliates had an impact on state funding for CTE. The impacts of professional organization unity, membership rates, and lobbying expenses on state-level CTE funding were analyzed through the lens of interest group theory, a subfield of political science. Within this population (N = 13), 1) a link …

Parent-Child Relationships And Parental Distress As Moderators Between Chronic Illness And Psychological Problems In Emerging Adults., Abigail Kukay

Theses and Dissertations

The current study aimed to better understand how parental functioning and parent-child relationships might moderate the effects of chronic illness on psychological problems in emerging adulthood. Three hypotheses were made: (1) the presence and severity of chronic illness would associate positively with emerging adult psychological problems, (2) parental distress would moderate the effects between chronic illness presence/severity and emerging adulthood psychological problems, and (3) parent-child relationship quality would moderate the effects between chronic illness presence/severity and emerging adult psychological problems. Data analysis consisted of testing interaction effects, pairwise parameter comparisons, and multiple group analysis. The three-way interaction between endorsing a …

Additively Manufactured Lenses For Modulating Guided Waves In Laminated Composites, Hajar Righi

Theses and Dissertations

Composite materials have increasingly been used as an alternative to metals and other isotropic materials for primary structural components in aerospace industries. Unlike traditional isotropic materials, composite materials are known to have complex internal microstructures. Therefore, it is essential to develop methods for the inspection, evaluation, and monitoring of composite materials. Ultrasonic-guided waves and, more precisely, Lamb waves have proven to be an efficient and accurate technique for the non-destructive testing. Since guided waves are dispersive and multimodal, it is important to develop a practical method to manipulate Lamb waves to achieve better structural health monitoring and non-destructive inspection results. …

Development Of A Crosslinked Osteochondral Xenograft And A Collagen Stabilizing Intra-Articular Injection To Remediate Cartilage Focal Lesions To Prevent Osteoarthritis, Mark Lewis Mosher

Theses and Dissertations

Osteoarthritis is one of the most common causes of disability in adults in America. It is a progressive and degenerative disease where the articular cartilage is broken down and lost from the surfaces of bones causing chronic pain and swelling in the joints, and currently has no cure. The most commonly osteoarthritis starts from a focal lesion on the cartilage surface, which will expand on the surface and downwards through the thickness of the tissue. The current gold standard for correcting cartilage focal lesions is the osteochondral autograft/allograft transplantation (OAT), which replaces the defect with a fresh osteochondral graft. The …

Effects Of Microcystin-Lr On Channel Catfish (Ictalurus Punctatus) Susceptibility To Microbial Pathogens (Aeromonas Hydrophila And Edwardsiella Piscicida), Alison Marchant

Theses and Dissertations

Microcystin-LR is a hepatotoxin produced by cyanobacteria. Aeromonas hydrophila and Edwardsiella piscicida infections are leading causes of losses in market-sized channel catfish (Ictalurus punctatus). These older fish should have natural immunity in place and a predisposing factor is likely a prerequisite for these disease outbreaks. While microcystin-LR rarely causes mortality in warm-water aquaculture, we believe it may be a predisposing factor that leads to bacterial disease outbreaks during the summer months due to its ability to damage the liver. Our study investigated microcystin-LR’s effects on channel catfish susceptibility to these pathogens. We found that a sublethal dose of microcystin-LR induced …

Inequity Of Access Across America: A Spatial, Temporal, And Modal Disparity Analysis, Sanju Maharjan

Theses and Dissertations

The overarching goal of this dissertation is to examine the spatial, temporal, and modal disparity of access across America. This is achieved by posing three research objectives. The first objective determines the spatial and temporal disparity of transit and automobile access gap, its impact on transit use, and its socioeconomic and built environment correlates. The second objective examines the spatial and temporal disparity of slightly and extremely risky bike infrastructure and measures the social inequity of access to bike infrastructure. The third objective indicates spatial transit access mismatch between high- and low-wage employment across metropolitans. Three findings are discerned. First, …

Vegetation And Nutritional Changes Over 20 Years Of White-Tailed Deer Exclusion, Gabrielle Nicole Ripa

Theses and Dissertations

Knowledge of the impacts of white-tailed deer (Odocoileus virginianus; hereafter deer) as dominant herbivores throughout the Southeastern United States of America is lacking. To address this, three paired experimental units of exclosures and controls were constructed in 2000 on three Wildlife Management Areas across Mississippi within the ecoregions of the Upper Coastal Plain, Lower Coastal Plain, and the Mississippi Alluvial Valley. Vegetation was sampled in the summers of 2000, 2005, and 2021 including vegetation structure, canopy coverage, basal area, and species composition. Additionally, in 2005 and 2021, biomass was sampled to determine potential impacts on nutritional carrying capacity. Among the …

Molecular And Phenotypic Characterization Of Escherichia Coli Isolated From Broiler Chicken Flocks In Mississippi, Priyanka Devkota

Theses and Dissertations

Avian pathogenic Escherichia coli (APEC) is the causative agent of colibacillosis. APEC causes significant economic losses to the poultry industry. In this study, 66 E. coli isolates were collected from broiler flocks across Mississippi and categorized as clinical and non-clinical isolates. Genotypic and phenotypic characterization of virulence factors and antimicrobial resistance profiles of these E. coli were examined. The data disclosed a higher prevalence of virulence genes in clinical isolates than in non-clinical isolates. High differences on the genotypic and phenotypic antimicrobial resistance among clinical and non-clinical isolates were observed. Whole genome sequences of avian E. coli elaborated a diverse …

Altered Dna Methylation Of Cyp2e1 Gene In Schizophrenia Patients With Tardive Dyskinesia, Ping Zhang, Yanli Li, Kesheng Wang, Junchao Huang, Brenda Bin Su, Chun Xu, Zhiren Wang, Shuping Tan, Fude Yang, Yunlong Tan

Health & Biomedical Sciences Faculty Publications

Background

About 20–30% of patients with schizophrenia develop tardive dyskinesia (TD). Oxidative stress is one potential causes of TD. CYP2E1 is considered as an oxidative stress-related gene, however, no study has been reported on the DNA methylation levels of the CYP2E1 in schizophrenia or TD.

Methods

A total of 35 schizophrenia patients with TD, 35 schizophrenia patients without TD (NTD), and 35 health controls (HCs) were collected in Beijing, China. DNA was extracted from peripheral blood samples. The promoter methylation levels of CYP2E1 were detected using pyrosequencing. The generalized linear model (GLM) was used to examine the methylation levels of …

Board Of Trustees Minutes, Dec. 9 2022, Indiana State University Board Of Trustees

Board of Trustees

No abstract provided.

Board Of Trustees Agenda, Dec. 9 2022, Indiana State University Board Of Trustees

Board of Trustees

No abstract provided.

Letter From The Editor: Coming Together As A Resilient Workforce, Nohemi Sadule Rios

Nursing & Health Sciences Research Journal

No abstract provided.

Editorial Board

Nursing & Health Sciences Research Journal

No abstract provided.

A Concept Analysis Of Moral Comfort In Nursing, Natalie Bermudez

Nursing & Health Sciences Research Journal

Introduction: Nurses are the most trusted professional group in the United States. As such, examination and exploration of concepts or phenomena, either positively or negatively affecting nurses’ ethical decision-making and moral actions, are needed. While nursing literature is abundant on moral distress and its negative impact, literature on moral comfort (a positive phenomenon) is sparsely available. The purpose of this concept analysis is to explore MC within nursing literature and other disciplines to identify moral comfort’s defining attributes, antecedents, consequences, and empirical referents.

Method: Walker and Avant’s eight-step concept analysis approach was used.

Results: Six articles were included in this …

Exploring Nurses' Confidence In Providing Support To Bereaved Families Following Stillbirth Fetal Loss, Silvia E. Salazar, Priscilla Kahn, Jill Costley, Roxana Linares, Natalie Bermudez

Nursing & Health Sciences Research Journal

Introduction: Stillbirth fetal loss (SFL) is a significant cause of infant death in the US, with 23,000 reported in 2017. Negative psychological and emotional repercussions of SFL, for parents and nurses, may be mitigated by nurses’ preparedness to provide bereavement support (BS). Several studies exploring BS for miscarriage-related fetal loss were found. However, studies exploring SFL BS and nurses’ preparedness for providing SFL BS are sparse. The purpose of this study was to assess nurses’ confidence and knowledge for providing BS to families experiencing stillbirth fetal loss.

Methods: This was a cross-sectional quantitative descriptive study. Postpartum registered nurses (RN) were …

Improving The Timing Of Insulin Administration In Adult Acute Care Patients, Hollie Gow, Harold Girado, Venessa Rodriguez, Lourdes Talavera, Leyner Martinez, Pierce R. Buzzi Davidson, Esty Trimino, Dayana M. Aguilera, Catherina Chang Martinez, Annette Caravia, Joy Mitts, Shelli Anne Marie Chernesky, Diana Maria Lopez, Hector Gonzalez, Sandy Jones, Sara Perez, Nell Mayendia Blanco, Orlando Bodes Ramil, Christopher Scott, Andrea Calvo, Jan V. Roy, Yaribey Lopez, Margie Martin, Angelines Diaz, Yessenia Muniz, Joey Carralero

Nursing & Health Sciences Research Journal

Background: The correct timing of insulin administration in diabetic patients admitted to the hospital is important for the prevention of transient and serious glycemic deviations that could lead to negative patient outcomes. In November 2021, a South Florida Hospital identified an area of opportunity for quality improvement related to the process of subcutaneous insulin administration. In addition to bar code scanning, manual verification of the insulin dose by the primary nurse and another nurse was required prior to administration. Patients were experiencing delays in the timing of their insulin dose and nurses were reporting frustration with the process. Methods: The …

Achieving 6th Magnet Designation Via Virtual Visit During The Covid-19 Pandemic, Lourdes C. Castaneda, Suzanne S. Spoerl, Catherina Chang Martinez

Nursing & Health Sciences Research Journal

Despite the challenges encountered with the arrival of the COVID-19 pandemic, Baptist Hospital of Miami achieved the prestigious American Nursing Credentialing Center Magnet 6^th designation. We describe the journey including writing the documents, preparing for the virtual visit, and efforts from key stakeholders to support the virtual site visit with the use of technology, to hold videoconferencing and tours “on wheels.” Nurses showcased their professional practice and excellence in patient care through exemplars and narratives presented during the virtual visit. Last, we provide recommendations for success to organizations contemplating a virtual site visit.

Residential Metals Abatement Program – Interior School Soil ‐ Remedial Action Work Plan – Butte High School, Mike Mcanulty

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Residential Metals Abatement Program – Interior School Soil ‐ Remedial Action Work Plan – Butte High School, Mike Mcanulty

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Process Development In Facilities Management Sector, Mohammad Zaher Aldiek

Theses

This capstone project focuses on the enhancement and optimization of different aspects within the facilities management department of Dubai Developments, which is a leading real estate company in Dubai. Considering the huge number of buildings owned by the company and that the facilities management department was recently formed, there are still opportunities of improvement in terms of saving energy, growing productivity, improving operations processes and promoting sustainability. To do so, this capstone project focused on developing four main aspects within the FM department to ensure achieving the abovementioned objectives. Firstly, a retrofit project was implemented on the cooling system of …

Associations Of Aspirin And Other Anti-Inflammatory Medications With Breast Cancer Risk By The Status Of Cox-2 Expression, Lusine Yaghjyan, A Heather Eliassen, Graham Colditz, Bernard Rosner, Pepper Schedin, Akemi Wijayabahu, Rulla M Tamimi

2020-Current year OA Pubs

BACKGROUND: We investigated the associations of aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) with breast cancer risk by the status of COX-2 protein expression.

METHODS: This study included 421 cases and 3,166 controls from a nested case-control study within the Nurses' Health Study (NHS) and Nurses' Health Study II (NHSII) cohorts. Information on medication use was first collected in 1980 (NHS) and 1989 (NHSII) and was updated biennially. Medication use was defined as none, past or current; average cumulative dose and frequency were calculated for all past or current users using data collected from all biannual questionnaires preceding the reference …

Endotoxin As A Marker For Water Quality, Anas A. Sattar, Christian R. Good, Margaux Saletes, João Brandão, Simon K. Jackson

School of Biomedical Sciences

Background: Water quality testing is vital to protect human health. Current testing relies mainly on culture-based detection of faecal indicator organisms such as Escherichia coli (E.coli). However, bacterial cultures are a slow process, taking 24–48 h and requiring specialised laboratories and trained personnel. Access to such laboratories is often sparse in developing countries and there are many fatalities deriving from poor water quality. Endotoxin is a molecular component of Gram-negative bacterial cell walls and can be used to detect their presence in drinking water. Method: The current study used a novel assay (BacterisK) to rapidly detect endotoxin in various water …

Exploring Right Ventricular Function Applicability In A Prediction Model To Identify Preterm Infants With Early Bronchopulmonary Dysplasia (Report-Bpd Study): A Mixed-Methods Observational Cohort Feasibility Study Protocol, Wisam S. Muhsen, Eirik Nestaas, Joanne Hosking, Jos Latour

Peninsula Medical School

Methods The mixed-methods observational cohort feasibility study, which comprises three work-packages (WPs), will be conducted at the regional neonatal unit, University Hospital Plymouth, Plymouth, UK. WP-I will recruit 40 preterm infants; each participant will have two heart scans performed in the first ten days after birth (DABs). WP-II will collect the documentation of the participating preterm infants’ parents in the study neonatal unit diaries in the first 10 DABs. WP-III will involve semi-structured interviews of 10–15 parents of participating preterm infants and 10–15 health professionals who participated in WP-I. The study recruitment will be conducted over 18-months. The start date …

Neddylated Cullin 3 Mediates The Adaptive Response To Topoisomerase 1 Inhibitors, Alice Meroni, Jan Grosser, Sumedha Agashe, Natasha Ramakrishnan, Jessica Jackson, Priyanka Verma, Laura Baranello, Alessandro Vindigni

2020-Current year OA Pubs

DNA topoisomerase 1 (TOP11) inhibitors are mainstays of anticancer therapy. These drugs trap TOP1 on DNA, stabilizing the TOP1-cleavage complex (TOP1-cc). The accumulation of TOP1-ccs perturbs DNA replication fork progression, leading to DNA breaks and cell death. By analyzing the genomic occupancy and activity of TOP1, we show that cells adapt to treatment with multiple doses of TOP1 inhibitor by promoting the degradation of TOP1-ccs, allowing cells to better tolerate subsequent doses of TOP1 inhibitor. The E3-RING Cullin 3 ligase in complex with the BTBD1 and BTBD2 adaptor proteins promotes TOP1-cc ubiquitination and subsequent proteasomal degradation. NEDDylation of Cullin 3 …