Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

2022

Discipline
Institution
Keyword
Publication
Publication Type
File Type

Articles 1891 - 1920 of 76362

Full-Text Articles in Entire DC Network

Pedicle Screw-Associated Violation Of The Adjacent Unfused Facet Joint: Clinical Outcomes And Fusion Rates, Nathan J. Sinz, Raymond W. Hwang, Gyu-Ho Lee, Kevin C. Baker, Paul Arnold, Rick Sasso, Daniel Park, Jeffrey Fischgrund, Ruijia Niu, David H. Kim Dec 2022

Pedicle Screw-Associated Violation Of The Adjacent Unfused Facet Joint: Clinical Outcomes And Fusion Rates, Nathan J. Sinz, Raymond W. Hwang, Gyu-Ho Lee, Kevin C. Baker, Paul Arnold, Rick Sasso, Daniel Park, Jeffrey Fischgrund, Ruijia Niu, David H. Kim

Orthopedics Articles

STUDY DESIGN: Retrospective review of a prospective randomized trial.

OBJECTIVES: To compare outcome scores and fusion rates in patients with and without pedicle screw-associated facet joint violation (FJV) after a single-level lumbar fusion.

METHODS: Clinical outcomes data and computed tomography (CT) imaging were reviewed for 157 patients participating in a multicenter prospective trial. Post-operative CT scans at 12-months follow-up were examined for fusion status and FJV. Patient-reported outcomes (PROs) included Oswestry Disability Index (ODI) and Visual Analog Scale (VAS) for leg and low back pain. Chi-square test of independence was used to compare proportions between groups on categorical measures. Two-sample …


Parent-Child Relationship Quality, Emotion Reactivity, And Suicide Ideation Among Adolescents, Deborah Schaeffer Dec 2022

Parent-Child Relationship Quality, Emotion Reactivity, And Suicide Ideation Among Adolescents, Deborah Schaeffer

Theses and Dissertations

The rate of teenage suicide has increased markedly in recent years, highlighting the need for greater understanding of the factors that underlie such behavior. While separate studies have established significant associations between the quality of the parent-child relationship and suicide ideation, and between emotion reactivity and suicide ideation, no prior research has examined the interaction of these variables. The current study used survey data collected from 111 youth recruited in emergency departments and inpatient units to measure parent-child relationship quality (the PACHIQ-R scale) and emotion reactivity (the ERS) as predictors of severity of suicide ideation at three months into the …


Back To The Roots: Black Veganism, Kiara R. Thomas Dec 2022

Back To The Roots: Black Veganism, Kiara R. Thomas

Capstones

Only 3% of Americans in general, but 8% of Black Americans are strict vegan or vegetarian. Whether it’s to reduce animal cruelty, manage a chronic illness, or connect with their heritage and build a social movement, Black people are embracing plant-based diets. https://kiarathomas429.github.io/portfolio/


More Muslim, Salman Ahad Khan Dec 2022

More Muslim, Salman Ahad Khan

Capstones

More Muslim is a show that explores the Muslim experience, with all its messiness.

Each episode is a narrative, transhistorical journey into one aspect of the Muslim experience that defined or is being defined by the modern world. This capstone forms the first two episodes of the series. Episode 1, "When Memes Meet Sufis," explores the question of how Rumi, a Muslim scholar from the 13th century, became the best-selling poet in the US. Episode 2, "The Halal Meat Conundrum," is a firsthand journey into the American halal meat industry and attempts to understand how halal became a $20 billion …


If You Live In New York City, You’Re (Probably) At Risk Of Flooding. Here’S What To Do About It. Digging Into The Information Needed To Live In Nyc As The Climate Changes, Christine A. Zirneklis Dec 2022

If You Live In New York City, You’Re (Probably) At Risk Of Flooding. Here’S What To Do About It. Digging Into The Information Needed To Live In Nyc As The Climate Changes, Christine A. Zirneklis

Capstones

New York City is a city of water — over 520 miles of rivers, ocean, canals and harbor. Historically, much of what is now New York city was wetlands and marshes. 1.3 Million New Yorkers, or about 15% of residents currently live in a coastal floodplain. More than half of those identify as non-white, and more than half live in areas with low median income.

As severe storms and rainfall become more common with the changing climate, many more neighborhoods further inland, away from the coast, are being impacted by inland flooding which is caused by sewer overflow. New York’s …


Food For Harlem, Izania Gonzalez Dec 2022

Food For Harlem, Izania Gonzalez

Capstones

Food for Harlem is a resource guide for Harlem residents to find local food-focused organizations. It’s a list for you to find where you can get healthy affordable food in your neighborhood. This project was created after the feedback I heard in discussion during my time at a food market in Harlem. The final product includes a complete list of over 70 food-focused organizations in Harlem, an interactive map, some important information about the included resources, and a list of definitions.

The website can be found here: https://imgjournalism.wixsite.com/food-for-harlem


Countering Dispossession: For Palestinians In The Diaspora, Maintaining Cultural Identity Is A Means Of Resistance, Reem Farhat Dec 2022

Countering Dispossession: For Palestinians In The Diaspora, Maintaining Cultural Identity Is A Means Of Resistance, Reem Farhat

Capstones

For decades, Palestinians have pushed back against Israeli appropriation of Palestinian culture, by calling it out online and making efforts to protect it through international organizations. On social media, Palestinians in the diaspora have resisted against erasure and appropriation of their heritage by learning, sharing, and teaching others about their culture online. Chef Nadia Gilbert, embroidery artist Asma Barakat, and TikToker Serena Rasoul have all maintained online presences dedicated to educating their followers on Palestinian culture. To them, practicing these aspects of their heritage in the diaspora is a means of resistance.

https://medium.com/@rfarhat1/countering-dispossession-for-palestinians-in-the-diaspora-maintaining-cultural-identity-is-a-e860d54bb8a9


The Future Of Universal Basic Income: The Impact Of Organizational Strategies On Alleviating Poverty And Maximizing Outcomes, Anna Mathews Dec 2022

The Future Of Universal Basic Income: The Impact Of Organizational Strategies On Alleviating Poverty And Maximizing Outcomes, Anna Mathews

Undergraduate Honors Theses

Universal basic income is gaining traction, with pilot programs being conducted all over the world. These programs are all organized differently, from their sources of funding to their eligibility criteria. This research draws correlations between organizational strategies of UBI programs and the outcomes their recipients experience. Specifically, it analyzes three contemporary UBI programs within the United States: the Stockton Economic Empowerment Demonstration (SEED), Alaska Permanent Fund Dividend (APFD), and the Eastern Band of Cherokee Indians per capita payments (EBCI). The research assesses the physical health, mental health, and economic outcomes of the participants in each case study, in order to …


The Quest For Influence: Examining Russia's Public Diplomacy Mechanisms In Africa, Isaac Antwiboasiako Dec 2022

The Quest For Influence: Examining Russia's Public Diplomacy Mechanisms In Africa, Isaac Antwiboasiako

Articles

This article examines Russian public diplomacy mechanisms in Africa. These include the intentional use of historical ties, various aid programmes in education and health, the targeted use of international broadcasting and digital media, and the exploitation of anti-Western sentiments on the continent. Russia employs these to win the hearts and minds of African publics for its national interest. The article first explores Moscow’s public diplomacy in general and analyses the challenges Russia faces in Africa, which has become a ‘dumping ground’ for public diplomacy campaigns by the US, the EU and its members, the UK, and China. The article argues …


Topics And Sentiment Surrounding Vaping On Twitter And Reddit During The 2019 E-Cigarette And Vaping Use-Associated Lung Injury Outbreak: Comparative Study, Dezhi Wu, Erin Kasson, Avineet Kumar Singh, Yang Ren, Nina Kaiser, Ming Huang, Patricia A. Cavazos-Rehg Dec 2022

Topics And Sentiment Surrounding Vaping On Twitter And Reddit During The 2019 E-Cigarette And Vaping Use-Associated Lung Injury Outbreak: Comparative Study, Dezhi Wu, Erin Kasson, Avineet Kumar Singh, Yang Ren, Nina Kaiser, Ming Huang, Patricia A. Cavazos-Rehg

Publications

BACKGROUND: Vaping or e-cigarette use has become dramatically more popular in the United States in recent years. e-Cigarette and vaping use-associated lung injury (EVALI) cases caused an increase in hospitalizations and deaths in 2019, and many instances were later linked to unregulated products. Previous literature has leveraged social media data for surveillance of health topics. Individuals are willing to share mental health experiences and other personal stories on social media platforms where they feel a sense of community, reduced stigma, and empowerment. OBJECTIVE: This study aimed to compare vaping-related content on 2 popular social media platforms (ie, Twitter and Reddit) …


December 13, 2022 Ereporter, University Of Alabama At Birmingham Dec 2022

December 13, 2022 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.


Lipid-Nanoparticle-Mediated Delivery Of Docetaxel Prodrug For Exploiting Full Potential Of Gold Nanoparticles In The Treatment Of Pancreatic Cancer, Abdulaziz Alhussan, Nolan Jackson, Sarah Eaton, Nancy Dos Santos, Ingrid Barta, Josh Zaifman, Sam Chen, Yuen Yi C Tam, Sunil Krishnan, Devika B Chithrani Dec 2022

Lipid-Nanoparticle-Mediated Delivery Of Docetaxel Prodrug For Exploiting Full Potential Of Gold Nanoparticles In The Treatment Of Pancreatic Cancer, Abdulaziz Alhussan, Nolan Jackson, Sarah Eaton, Nancy Dos Santos, Ingrid Barta, Josh Zaifman, Sam Chen, Yuen Yi C Tam, Sunil Krishnan, Devika B Chithrani

Faculty, Staff and Student Publications

Current chemoradiation therapy suffers from normal tissue toxicity. Thus, we are proposing incorporating gold nanoparticles (GNPs) and docetaxel (DTX), as they have shown very promising synergetic radiosensitization effects. Here, we explored the effect of a DTX prodrug encapsulated in lipid nanoparticles (LNPDTX-P) on GNP uptake in pancreatic cancer models in vitro and in vivo. For the in vitro experiment, a pancreatic cancer cell line, MIA PaCa-2, was cultured and dosed with 1 nM GNPs and 45 nM free DTX or an equivalent dose of LNPDTX-P. For the in vivo experiment, MIA PaCa-2 cells were implanted subcutaneously …


System Of Language Learning With Augmented Reality, Sara Ashley Smith, Maria Soledad Carlo, Sanghoon Park, Howard Kaplan Dec 2022

System Of Language Learning With Augmented Reality, Sara Ashley Smith, Maria Soledad Carlo, Sanghoon Park, Howard Kaplan

USF Patents

Education curricula materials include encoded indicia such as a QR code that contains information related to identifying requested augmented reality image data from a server over a network. By scanning the QR code, a computer uses its decoding software to create a data set for transmitting to the server. The data set may include an identifier for selected augmented reality image data associated with the user's curriculum, information about the curriculum at issue, the academic level of the user, and any other data necessary to ensure that the most appropriate augmented reality image data is transmitted back to the computer. …


Increasing Collaboration To Improve Student Outcomes: Improvement Science, Cassandra Diane Thonstad Dec 2022

Increasing Collaboration To Improve Student Outcomes: Improvement Science, Cassandra Diane Thonstad

Dissertations and Theses

The aspiration of achieving equitable outcomes for all students is a focus of schools, districts, and communities but has largely remained unattainable with the top-down implementation of change ideas and directives that come and go as quickly as they are implemented. Too often the direct users, students and classroom staff, are left out of the conversations around what works best to improve student success, contributing to the achievement gaps experienced by our students of color, students receiving special education or English language services, or in the case of a hook discipline, young men. By utilizing Improvement Science through collaboration across …


Gata1 Controls Numbers Of Hematopoietic Progenitors And Their Response To Autoimmune Neuroinflammation, Daniel Hwang, Larissa Ishikawa, Maryam S. Seyedsadr, Elisabeth R. Mari, Ezgi Kasimoglu, Ziver Sahin, Alexandra Boehm, Soohwa Jang, Javad Rasouli, Courtney Vaccaro, Michael Gonzalez, Hakon Hakonarson, Mohamad Rostami, Guang-Xian Zhang, Bogoljub Ciric Dec 2022

Gata1 Controls Numbers Of Hematopoietic Progenitors And Their Response To Autoimmune Neuroinflammation, Daniel Hwang, Larissa Ishikawa, Maryam S. Seyedsadr, Elisabeth R. Mari, Ezgi Kasimoglu, Ziver Sahin, Alexandra Boehm, Soohwa Jang, Javad Rasouli, Courtney Vaccaro, Michael Gonzalez, Hakon Hakonarson, Mohamad Rostami, Guang-Xian Zhang, Bogoljub Ciric

Department of Neurology Faculty Papers

GATA-binding factor 1 (GATA1) is a transcription factor that governs the development and function of multiple hematopoietic cell lineages. GATA1 is expressed in hematopoietic stem and progenitor cells (HSPCs) and is essential for erythroid lineage commitment; however, whether it plays a role in hematopoietic stem cell (HSC) biology and the development of myeloid cells, and what that role might be, remains unclear. We initially set out to test the role of eosinophils in experimental autoimmune encephalomyelitis (EAE), a model of central nervous system autoimmunity, using mice lacking a double GATA-site (ΔdblGATA), which lacks eosinophils due to the deletion of the …


Board Of Trustees Minutes, December 13, 2022, Coastal Carolina University Dec 2022

Board Of Trustees Minutes, December 13, 2022, Coastal Carolina University

Board of Trustees Meeting Minutes

No abstract provided.


Diverse College Students' Cultural Background And College Persistence, Kerrie Devries, Jonathan Santo, Juan Casas Dec 2022

Diverse College Students' Cultural Background And College Persistence, Kerrie Devries, Jonathan Santo, Juan Casas

Psychology Faculty Publications

Tinto (1975) created a college persistence model, emphasizing institutional academic and social integration, that continues to guide U.S. university retention strategies. This longitudinal study followed 584 college Freshman from diverse backgrounds, testing for group differences in the relationship that Tinto’s key constructs have on college persistence, over time, for U.S.-White, U.S.-minority, and immigrant-origin groups. We found significant positive associations between Academic Integration and Intentions to Persist for all ethnic groups, but group differences in Social Integration and Intentions to Persist. Additionally, Intentions to Persist was a significant predictor of actual persistence for all groups, suggesting predictive power overall.


Realizing Potential: From Where You Are Today To Where You Can Be, Cora O'Leary Dec 2022

Realizing Potential: From Where You Are Today To Where You Can Be, Cora O'Leary

General Webinars

This webinar is designed to help the nurse think about their career path and how to seize opportunities as they come along in their career trajectory. The content will help the nurse reflect on their current work life and help to generate thoughts about the career potential that exists within the profession.


Scientology's Faq: Sciencing, Tech-Romancing, Simulacra, & Simulation An Estranged Content Analysis, David Scott Morrill Dec 2022

Scientology's Faq: Sciencing, Tech-Romancing, Simulacra, & Simulation An Estranged Content Analysis, David Scott Morrill

Dissertations and Theses

This thesis examines how the practice of sciencing, tech-romancing, simulacra, and simulation manifests in both the text and symbols used on audiences of the Church of Scientology’s outreach materials. It specifically examines its official FAQ page. Self-framing was observed that satisfied the definition of sciencing and tech-romancing. Under an Estranged approach, Morrill examined selections of the Church’s FAQ pages, coding for instances of sciencing, tech-romancing, simulacra, and simulation. The data indicate that the Church frequently adopts simulacra and engages in simulation. The Church was seen frequently adopting technological and scientific symbols and jargon. The degree of sciencing, tech-romancing, simulacra, and …


Mothers Of Disabled Children Faced Numerous Challenges During The Covid-19 Pandemic, Amy Lutz, Sujung (Crystal) Lee, Baurzhan Bokayev Dec 2022

Mothers Of Disabled Children Faced Numerous Challenges During The Covid-19 Pandemic, Amy Lutz, Sujung (Crystal) Lee, Baurzhan Bokayev

Population Health Research Brief Series

The COVID-19 pandemic changed life dramatically for most families, but particularly for families with a disabled child. Mothers of disabled children faced increased difficulties during the early months of COVID-19 compared to other families. Reduction in services, school closures, and managing paid work drastically impacted caregivers’ mental health. This brief summarizes results from a recent study on the challenges mothers of disabled children faced during the COVID-19 pandemic during the Spring of 2020 in Central New York.


Effect Of Decreased Snowpack On A Rare Butterfly’S Host Plant, Caitlin Mchugh Dec 2022

Effect Of Decreased Snowpack On A Rare Butterfly’S Host Plant, Caitlin Mchugh

Biology Student Scholarship

Earth’s increased global temperature as a response to climate change has caused less snowfall and earlier snowmelt in spring. These changes can alter the phenology of organisms such as through plant leafing and flower blooming. This can be harmful to species reliant on plants that are more sensitive to temperature changes. The frosted elfin (Callophrys irus) is a species of concern in 11 states—including RI, MA, and CT. These host plant specialists only lay eggs on small yellow wild indigo (Baptisia tinctoria) and wild lupine (Lupinus perennis). If neither plant emerges and develops leaves …


Comparison Between Supervised And Unsupervised Learning For Autonomous Delamination Detection Using Impact Echo, Faezeh Jafari, Sattar Dorafshan Dec 2022

Comparison Between Supervised And Unsupervised Learning For Autonomous Delamination Detection Using Impact Echo, Faezeh Jafari, Sattar Dorafshan

Civil Engineering Faculty Publications

Impact echo (IE) is a non-destructive evaluation method commonly used to detect subsurface delamination in reinforced concrete bridge decks. Existing analysis methods are based on frequency domain which can lead to inaccurate assessments of reinforced concrete bridge decks since they do not consider features of the IE signals in the time domain. The authors propose a new method for IE classification by combining features in the time and the frequency domains. The features used in this study included normalized peak values, energy, power, time of peaks, and signal lengths that were extracted from IE signals after they are preprocessed. We …


Pum1 Mediates The Posttranscriptional Regulation Of Human Fetal Hemoglobin, Yuncheng Man, Amma Owusu-Ansah, Omar Y. Mian, Umut A. Gurkan, Anton A. Komar, Merlin Nithya Gnanapragasam Dec 2022

Pum1 Mediates The Posttranscriptional Regulation Of Human Fetal Hemoglobin, Yuncheng Man, Amma Owusu-Ansah, Omar Y. Mian, Umut A. Gurkan, Anton A. Komar, Merlin Nithya Gnanapragasam

Faculty Scholarship

The fetal-to-adult hemoglobin switching at about the time of birth involves a shift in expression from γ-globin to β-globin in erythroid cells. Effective re-expression of fetal γ-globin can ameliorate sickle cell anemia and β-thalassemia. Despite the physiological and clinical relevance of this switch, its posttranscriptional regulation is poorly understood. Here, we identify Pumilo 1 (PUM1), an RNA-binding protein with no previously reported functions in erythropoiesis, as a direct posttranscriptional regulator of β-globin switching. PUM1, whose expression is regulated by the erythroid master transcription factor erythroid Krüppel-like factor (EKLF/KLF1), peaks during erythroid differentiation, binds γ-globin messenger RNA (mRNA), and reduces γ-globin …


Biofilm Characterization And The Potential Role Of Edna In Horizontal Gene Transfer In Hospital And Meat Isolates Of Staphylococcus Aureus And Their Biofilms, Ashley Lynne Ball Dec 2022

Biofilm Characterization And The Potential Role Of Edna In Horizontal Gene Transfer In Hospital And Meat Isolates Of Staphylococcus Aureus And Their Biofilms, Ashley Lynne Ball

Theses and Dissertations

Staphylococcus aureus is a pathogen responsible for a wide variety of life-threatening diseases such as bacteremia, endocarditis, and pneumoniae. S. aureus has been a major concern in recent years due to the rampant spread of antibiotic resistance. The ability of S. aureus to form biofilms aids in the spread of antibiotic resistance as biofilms are a known hotspot for horizontal gene transfer. Biofilms also protect cells from host immune responses and antibiotics, making these infections very difficult to treat. The matrix of S. aureus biofilms can be made of polysaccharides, protein, and DNA. In these studies, we sought to elucidate …


Methemoglobin Formation Via Nitric Oxide And Comparison Of Methemoglobin, Deoxyhemoglobin, And Ferrous Nitrosyl Hemoglobin As Potential Mri Contrast Agents, Roya Ayati Dec 2022

Methemoglobin Formation Via Nitric Oxide And Comparison Of Methemoglobin, Deoxyhemoglobin, And Ferrous Nitrosyl Hemoglobin As Potential Mri Contrast Agents, Roya Ayati

Theses and Dissertations

Gadolinium-based contrast agents (GBCAs) are in widespread use to enhance magnetic resonance angiography images for evaluating vascular pathology. However, there are safety concerns and limitations regarding the use of GBCAs. It has been shown that the magnetic resonance imaging (MRI) signal intensity (T1-weighted images) in some of the brain's tissues is higher for patients who had multiple exposures to GBCAs compared to patients who had never had exposure to GBCAs. This implies that GBCAs are not sufficiently removed from body such that GBCAs may potentially have long-term effects on the human body. These potential safety concerns have led to an …


Evaluating Equitable Access To Nutrition In Utah, Emma Stucki Dec 2022

Evaluating Equitable Access To Nutrition In Utah, Emma Stucki

Theses and Dissertations

One of the more recent topics in transportation policy making and project prioritization in DOT's across the United States is how to improve quality of life. This quality of life focus is an intersection of public health and transportation and has many different branches including traffic safety, pollution, active transportation, equity, and accessibility to resources. The topic among these that seems to receive the least attention is equitable access to resources. However, with the proven impact that equitable access to resources has on physical and emotional well-being, as well as economic opportunity it is important to ensure that all populations, …


A Program Evaluation Of The Project Roomkey In Santa Clara, San Francisco, And Alameda Counties, Louella Sevegan Dec 2022

A Program Evaluation Of The Project Roomkey In Santa Clara, San Francisco, And Alameda Counties, Louella Sevegan

Master's Projects

During the early months of 2020, the rapid spread of SARS-CoV-2 (COVID-19) had a significant impact on the homeless population. The U.S. Department of Housing and Urban Development, Office of Community Planning and Development defines a homeless person as someone who "lacks a fixed, regular, and adequate nighttime residence" (Henry, et al., 2020, page 2). According to a report conducted by Culhane et al. (2020), the homeless population has a higher chance of being infected by COVID-19 than the general population. Issues such as inadequate access to sanitation or proper hygiene, and the inability to isolate, especially in a congregate …


Department Of Children's Services, December 2022, Tennessee. Comptroller Of The Treasury. Dec 2022

Department Of Children's Services, December 2022, Tennessee. Comptroller Of The Treasury.

Performance Audit Reports

No abstract provided.


Computer Clinical Decision Support That Automates Personalized Clinical Care: A Challenging But Needed Healthcare Delivery Strategy, Alan H Morris, Christopher Horvat, Brian Stagg, David W Grainger, Michael Lanspa, James Orme, Terry P Clemmer, Lindell K Weaver, Frank O Thomas, Colin K Grissom, Ellie Hirshberg, Thomas D East, Carrie Jane Wallace, Michael P Young, Dean F Sittig, Mary Suchyta, James E Pearl, Antinio Pesenti, Michela Bombino, Eduardo Beck, Katherine A Sward, Charlene Weir, Shobha Phansalkar, Gordon R Bernard, B Taylor Thompson, Roy Brower, Jonathon Truwit, Jay Steingrub, R Duncan Hiten, Douglas F Willson, Jerry J Zimmerman, Vinay Nadkarni, Adrienne G Randolph, Martha A Q Curley, Christopher J L Newth, Jacques Lacroix, Michael S D Agus, Kang Hoe Lee, Bennett P Deboisblanc, Frederick Alan Moore, R Scott Evans, Dean K Sorenson, Anthony Wong, Michael V Boland, Willard H Dere, Alan Crandall, Julio Facelli, Stanley M Huff, Peter J Haug, Ulrike Pielmeier, Stephen E Rees, Dan S Karbing, Steen Andreassen, Eddy Fan, Roberta M Goldring, Kenneth I Berger, Beno W Oppenheimer, E Wesley Ely, Brian W Pickering, David A Schoenfeld, Irena Tocino, Russell S Gonnering, Peter J Pronovost, Lucy A Savitz, Didier Dreyfuss, Arthur S Slutsky, James D Crapo, Michael R Pinsky, Brent James, Donald M Berwick Dec 2022

Computer Clinical Decision Support That Automates Personalized Clinical Care: A Challenging But Needed Healthcare Delivery Strategy, Alan H Morris, Christopher Horvat, Brian Stagg, David W Grainger, Michael Lanspa, James Orme, Terry P Clemmer, Lindell K Weaver, Frank O Thomas, Colin K Grissom, Ellie Hirshberg, Thomas D East, Carrie Jane Wallace, Michael P Young, Dean F Sittig, Mary Suchyta, James E Pearl, Antinio Pesenti, Michela Bombino, Eduardo Beck, Katherine A Sward, Charlene Weir, Shobha Phansalkar, Gordon R Bernard, B Taylor Thompson, Roy Brower, Jonathon Truwit, Jay Steingrub, R Duncan Hiten, Douglas F Willson, Jerry J Zimmerman, Vinay Nadkarni, Adrienne G Randolph, Martha A Q Curley, Christopher J L Newth, Jacques Lacroix, Michael S D Agus, Kang Hoe Lee, Bennett P Deboisblanc, Frederick Alan Moore, R Scott Evans, Dean K Sorenson, Anthony Wong, Michael V Boland, Willard H Dere, Alan Crandall, Julio Facelli, Stanley M Huff, Peter J Haug, Ulrike Pielmeier, Stephen E Rees, Dan S Karbing, Steen Andreassen, Eddy Fan, Roberta M Goldring, Kenneth I Berger, Beno W Oppenheimer, E Wesley Ely, Brian W Pickering, David A Schoenfeld, Irena Tocino, Russell S Gonnering, Peter J Pronovost, Lucy A Savitz, Didier Dreyfuss, Arthur S Slutsky, James D Crapo, Michael R Pinsky, Brent James, Donald M Berwick

Faculty, Staff and Student Publications

How to deliver best care in various clinical settings remains a vexing problem. All pertinent healthcare-related questions have not, cannot, and will not be addressable with costly time- and resource-consuming controlled clinical trials. At present, evidence-based guidelines can address only a small fraction of the types of care that clinicians deliver. Furthermore, underserved areas rarely can access state-of-the-art evidence-based guidelines in real-time, and often lack the wherewithal to implement advanced guidelines. Care providers in such settings frequently do not have sufficient training to undertake advanced guideline implementation. Nevertheless, in advanced modern healthcare delivery environments, use of eActions (validated clinical decision …


Hypermethylation Of Nc886 In Hpv-Positive Oropharyngeal Cancer And Its Clinical Implications: An Epigenome-Wide Association Study, Yifan Xu, Ziqiao Wang, Peng Wei, Richa Gairola, Karl T Kelsey, Andrew G Sikora, Guojun Li, Jian Gu Dec 2022

Hypermethylation Of Nc886 In Hpv-Positive Oropharyngeal Cancer And Its Clinical Implications: An Epigenome-Wide Association Study, Yifan Xu, Ziqiao Wang, Peng Wei, Richa Gairola, Karl T Kelsey, Andrew G Sikora, Guojun Li, Jian Gu

Faculty, Staff and Student Publications

The incidence of oropharyngeal squamous cell carcinoma (OPSCC) has increased rapidly in the United States, driven by rising human papillomavirus (HPV) infections in the U.S. population. HPV-positive OPSCC patients have a better prognosis than HPV-negative patients. To gain insights into the unique biology of HPV(+) OPSCC that may contribute to its clinical behaviors, we performed a multi-stage epigenome-wide methylation profiling of leukocyte and tumor DNA in OPSCC patients and compared the methylation levels of CpG sites between HPV(+) and HPV(-) OPSCC patients. We identified and validated a significantly differentially methylated region (DMR) of 1,355 bp encompassing non-coding RNA 886 ( …