Digital Commons Network^™

Ex Vivo Drug Sensitivity Correlates With Clinical Response And Supports Personalized Therapy In Pediatric Aml, Debbie C Strachan, Christine J Gu, Ryosuke Kita, Erica K Anderson, Michelle A Richardson, George Yam, Graham Pimm, Jordan Roselli, Alyssa Schweickert, Maci Terrell, Raushan Rashid, Alan K Gonzalez, Hailey H Oviedo, Michelle C Alozie, Tamilini Ilangovan, Andrea N Marcogliese, Hiroomi Tada, Marianne T Santaguida, Alexandra M Stevens

Faculty, Staff and Students Publications

Acute myeloid leukemia (AML) is a heterogeneous disease that accounts for ~20% of all childhood leukemias, and more than 40% of children with AML relapse within three years of diagnosis. Although recent efforts have focused on developing a precise medicine-based approach towards treating AML in adults, there remains a critical gap in therapies designed specifically for children. Here, we present ex vivo drug sensitivity profiles for children with de novo AML using an automated flow cytometry platform. Fresh diagnostic blood or bone marrow aspirate samples were screened for sensitivity in response to 78 dose conditions by measuring the reduction in …

Investigating Student Development Of Intercultural Communicationcompetence Through Collaborative Online International Learning, Yizhe Huang

Journal of Comparative & International Higher Education

This dissertation is a qualitative case study detailing the intercultural communication competence (ICC) development of seven Chinese foreign language learners who participated in Collaborative Online International Learning (COIL) activities at a regional U.S. university with a group of native Chinese speakers. Multiple qualitative data sources - including semi-structured interviews, observations, questionnaires, and reflection journals - were collected over two years. Drawing on sociocultural and transformative learning theories, this study disclosed four findings that practitioners and researchers can build upon to promote language development and intercultural learning in foreign language coursework through virtual exchange.

Dealing With Acculturative Stress: How International Students’ Personality Traits Help?, Thu Thi Kim Le

Journal of Comparative & International Higher Education

Studies on international students have gained popularity over the past decades, especially; international students’ experience on acculturative stress has been a significant research topic for researchers in different countries. However, there remains a gap in how personality traits influence the ways that international students deal with acculturative stress. This study aims to investigate acculturative stress-related experiences of five international students from five countries studying in Canada. Applying a collective case study as a qualitative research method and collecting data from semi-structured in-depth interviews, this study expects to describe levels of stress that these students encounter and explore how their personality …

The Inter-Play Of Teacher Agency And Student Agency In Enhancing Graduate Employability: A Study Of The International Career-Oriented Programs In Vietnam, Thi Duc Phung

Journal of Comparative & International Higher Education

Although the Vietnamese government has launched numerous initiatives to develop employability for students, half of its university graduates are unable to find jobs in their area of specialization. In order to address this issue, the Vietnamese higher education sector has introduced international career-oriented programs (ICOPs) to position the quality of Vietnamese graduates on par with international standards. This research focuses on three ICOPs to explore the interaction between teacher and student agency in enhancing graduate employability. This research draws on Bourdieu's concepts of field, capital, and habitus to investigate how academics and students perceive and exercise their individual agency. The …

The Role Of Academic Mobility In The (De)Construction Of Internationalization: Dialogues And Perspectives From, In And On Global South & Global North, Ana Rachel M. Mendes

Journal of Comparative & International Higher Education

International mobility has played a central role in the views, policies, and actions of internationalization of higher education, despite representing a highly excluding, elitist process with flows that tend to reinforce asymmetrical relationships and colonial domination by the Global North of the Global South. Therefore, this study seeks to investigate how the international mobility is related to the construction of internationalization. To this end, the views of students and professors participating in the academic mobility of one university in Brazil, the Global South, and another in Spain, the Global North, will be analyzed through interviews and later they will be …

Gendered Experiences Of Human Dignity Within Canadian Universities: The Case Of Iranian International Students, E. Razavipour

Journal of Comparative & International Higher Education

This article explores Iranian international students’ (IISs) experiences of human dignity (HD) within Canadian universities, compared to Iranian ones. Drawing on in-depth interviews with 24 current and former IISs (10 women and 10 men in Montreal and two women and two men who had left Canada), I created a conceptual HD framework to analyze the data. Three themes emerged as key to IISs’ experiences of HD in the context of postsecondary education: 1) the relationship between students and university faculty/staff, 2) gender equality and freedom, and 3) having a minority or marginalized identity. I conclude with observations about how an …

Feminine Body Between Appropriation And Tyranny In Sulaiman Al- Shatti’S Novel "Silence Extends", “Semiotic Reading”, Khitam Othman Al-Khouli

Association of Arab Universities Journal for Arts مجلة اتحاد الجامعات العربية للآداب

This paper addresses the phenomena of appropriation and tyranny in the face of the feminine body in the novel "Extending Silence" by the Kuwaiti novelist Sulaiman al- Shatti. It depends on the analytical method that includes the following elements: the connotation of the title, the authoritarian woman, the oppressed woman, and the semiotics of the body. It discusses the key phenomena that surface the novel. As regards the connotation of the title, it is an efficacious element that shows up the theme of silence that extends throughout the novel and becomes a dominant element in the space of the narrative …

Potential Water Harvesting Sites Selection Using Spatial Multi-Criteria Modeling In Wadi Al Mujib Basin In Southern Jordan, Samer Alnawaiseh, Maysoon Alzghoul

Association of Arab Universities Journal for Arts مجلة اتحاد الجامعات العربية للآداب

This study aims to select potential sites for water harvesting by using Spatial Multi-Criteria modeling in the Wadi Al-Mujib basin as this method is one of the most suitable methods applied in arid and semi-arid areas to take advantage of rainwater. The significance of the study is to identify the best sites of pits and dams suitable for collecting rainwater in the Wadi Mujib basin through developing a spatial model based on the technology of Geographic Information Systems (GIS) and Remote Sensing (RS). In analyzing and identifying the best suitable sites in the Wadi Mujib basin, this paper uses an …

"I Am Primarily A Scientific Philologist": J.R.R. Tolkien And The Science/Technology Divide, Kristine Larsen

Journal of Tolkien Research

Presentation on Tolkien's writings on science and technology, New York Tolkien Conference, Baruch College, New York, March 17, 2019

Commencement [Program], December 17, 2022, University Of Northern Iowa

UNI Commencement Programs

The program of the commencement ceremonies, including a list of institutional leadership, a list of the departments by college, awards given at the ceremonies, and a list of undergraduate and graduate degree candidates. This commencement program is not an official graduate list.

A Horn Microstrip Transmission Line For The Characterization And Investigation Of Multipactor At Various Pressure And Power, Shaho Hamadamin

Electrical and Computer Engineering ETDs

The University of New Mexico is designing, building, and testing a multipactor testbed based on a horn-microstrip transmission line to characterize and investigate the multipactor effect for a range of vacuum pressures and power. A horn-shaped, 50 Ω Al microstrip line is positioned inside a six-way cross stainless-steel chamber that is vacuumed down to low ~10−7 torr. A 100 𝑀𝑀𝑀𝑀𝑀𝑀 sine signal is fed to a rf amplifier with a bandwidth of 250 − 105 𝑀𝑀𝑀𝑀𝑀𝑀, that can reach 120𝑊𝑊 average (CW) power. Two multipacting detection methods, i.e., global, and local methods, are implemented for accurate multipaction detection. The former …

Protection And Control Of Electric Power Grid Under High Penetration Of Ders, Binod Prasad Poudel

Electrical and Computer Engineering ETDs

Modernizing power grids with communication-based technologies has introduced new challenges to the operation of the grid, especially when the communication network experiences failure or data is corrupted during the transfer. This issue is studied in this dissertation from the control and protection perspective. First, the cyber attack detection and mitigation of distributed control of microgrids is addressed when the distributed energy resources (DER) are exposed to false data injection attacks. A cyber-threat detection technique is proposed based on Kullback-Liebler divergence-based criterion. This criterion with a threshold can detect the misbehavior of a compromised DER control unit and, consequently, calculates the …

“Women Who Speak With The Power And Authority Of God”: The Role Of Women In The Northern Indian Mission, 1964-1973, Amber Miller

Student Works

Since the Church's founding in the early 19th century, numerous historians have chronicled the story of "Lamanite" Missions for the Church of Jesus Christ of Latter-day Saints. Most of these Indian Mission histories, however, mention little more about women than missionaries marrying Native women, and non-native women receiving blessings that they will one-day teach the "Lamanites." Although the continuing conversation of these historic missions covers a wide range of views and interpretations, the roles and contributions of women often take a subordinate position in the Indian Mission narrative. The Northern Indian Mission of 1964 to 1973 serves as a microcosm …

Stories, Elizabeth Stuart Phelps, Roxanne Harde , Editor

Zea E-Books Collection

Today, Elizabeth Stuart Phelps (1844–1911) is best known for a handful of her novels: The Gates Ajar (1868), The Silent Partner (1871), and The Story of Avis (1877). During her life, however, the short story was a hugely popular genre in which she was fully invested and where she made a good deal of her living. Stories were her earliest and latest publications, and they were work that she both enjoyed and employed to greater ends. From 1864 to her death in 1911, she published almost one hundred and fifty short stories in the leading periodicals of the day. This …

Accuracy, Precision, And Efficiency: Comparing Mapping Techniques In Nixtun-Ch’Ich’, Petén, Guatemala, Gabriela Zygadlo

Theses and Dissertations

New archaeological survey technologies have transformed the way in which sites are mapped. Nixtun-Ch’ich’ in Petén, Guatemala has been surveyed in a variety of ways including a theodolite with an electronic distance measurement (EDM), total station (TS), laser imaging, detection and ranging (LiDAR), and photogrammetry. This paper aims to compare various mapping techniques and their accuracy, precision, and efficiency when pertaining specifically to mapping in Nixtun-Ch’ich’, Petén, Guatemala. The goal is to evaluate which technique is most efficient when mapping in the site by considering the variables of cost, time, and environment of the site. The paper also considers the …

Crafting A Presence: How Muslim Designers Are Making Their Mark, Imani S. White

Capstones

Muslim designers and models, specifically those who wear hijab, or the Islamic headcovering, are changing the focus of mainstream fashion. They're challenging norms, subverting ideology, and redefining what fashion can mean and who it can include. A handful of Muslim designers sat down with me to discuss how their religious beliefs influced their craft — if it does at all. We also delve into the challenges faced by hijabi designers in an industry that sometimes tokenizes them, emphasizing the importance of individuality and agency. Furthermore, the article touches upon the intersection of fashion, Islam, and sustainability, with new designers like …

New York City Lacks The Resources To Keep Cyclists Happy (Or Safe) But Help Is On The Way, Richard Heaton

Capstones

Across New York City, the disparity in bike resources has been on the rise, leaving many New Yorkers without access to dedicated bike lanes or other resources. This is especially prevalent in the outer boroughs, but thankfully there are organizations that look to remedy this in the future.

https://richard-heaton.medium.com/new-york-city-lacks-the-resources-to-keep-cyclists-happy-or-safe-but-help-is-on-the-way-15235462f199

Potential Benefits Of The Campus Outdoor Built Environment On Student Stress, Leading To Improved Retention, Kevin Dilliard

Graduate Liberal Studies Theses and Dissertations

University landscape managers often ask themselves, are they making a difference? Since what they do is not a revenue-generating department, how can they validate their true worth beyond making the campus beautiful, which is excellent, but what added value do they bring? As is common practice, when economic times get tough, the landscape department budget is one of the first to be cut, but is that the wisest thing to do? This research was intended to explore the concept that the services landscape managers provide have a return on investment by providing an environment in which students can thrive and …

2022 Fall Commencement, Harding University

Commencement Programs

Program for the Harding University Commencement on December 17.

Commencement Speaker: Susan Hutchinson

Cultivating Lifelong Readers: A Study Of How English Teachers Can Bring Pleasure Back Into The Reading Lives Of Students, Kaylie Jo Schertzing

Masters Projects

Research has revealed that many of today’s students are not reading for pleasure. Although research shows that recreational reading is linked with academic success, educational policies have left reading for pleasure out of focus and instead emphasize a particular type of reading that is assessed on mandated tests. As a result of curriculum reforms, English Language Arts curriculum has been narrowed and left reading for pleasure out of focus. This project explores the history of curriculum reform in the United States as it relates to the teaching of English Language Arts as well as recent research surrounding how recreational reading …

The Rescue Of Banks In Crisis." In Ethics In Banking: Is It Possible?, Cristina Rovera

Documents

No abstract provided.

Architects Of Abundance: Indigenous Regenerative Food And Land Management Systems And The Excavation Of Hidden History, Lyla June Johnston

Indigenous Studies

Pre-Columbian and contemporary Indigenous Nations of North and South America (hereafter referred to as Turtle Island and Abya Yala) have managed ecosystems extensively to produce prolific and predictable food systems for themselves and non-humans, whom they often view as relatives. The elements of earth, water, fire, and air are explored to analyze Indigenous soil management, Indigenous aquaculture, Indigenous pyrogenic land management, and Indigenous oral histories, respectively. First, a review of four Indigenous societies and their soil management techniques revealed that none of these systems require outside fertilizer or irrigation to sustain ecocentric food systems on millennial scales. Second, a comparative …

I'M A Killer Whale: The Process Of Cultural Identity Development From The Perspectives Of Young Indigenous Children, Angela Lunda

Indigenous Studies

This qualitative single case study examined the phenomenon of cultural identity development from the perspective of young Indigenous children situated within the context of their southeast Alaskan community. Decades of assimilationist policies have eroded cultural identity among many Indigenous Alaskans, yet a strong cultural identity is known to be a protective factor for Indigenous peoples. Building on Indigenous identity development theory, the study sought to answer the research questions: (1) How do young children demonstrate their cultural identity through interactions on the Land? (2) How do community organizations support cultural identity development (CID) in young Indigenous children? (3) What role …

Formation And Interrogation Of A Modeling Excel Database For Sorbent Preconcentrate With Gc/Ms, Lisa Caravello

Chemical and Biological Engineering ETDs

Volatile organic compounds (VOCs) are of great interest and the subject of much research, as they can be used in various applications. Preconcentrating this class of analytes is necessary as they can be elusive with simple sampling techniques. VOCs are often captured using sorbents in thermal desorption tubes as preconcentrates prior to analysis, commonly gas chromatography mass spectroscopy (GCMS). There are gaps in knowledge in behavior of materials used as sorbents i.e., if they will retain an analyte of interest appropriately. In this research I seek to eliminate speculation and unknown variables of analyte and sorbent combinations by creating a …

Perinatal Exercise Effectiveness To Prevent Offspring High-Altitude Pulmonary Hypertension, Eric Leslie

Health, Exercise, and Sports Sciences ETDs

The effectiveness of perinatal exercise (i.e., exercise by mothers immediately prior to, throughout, and after pregnancy) to attenuate high-altitude pulmonary hypertension and associated health consequences in the offspring exposed to chronic hypoxia in early life was investigated. Four groups were used to compare the effects of perinatal exercise to offspring exposed to low altitude (i.e., normoxic) conditions or simulated 4500 meters of high altitude (i.e., hypoxic) as well as their respective, sedentary controls. Offspring in the hypoxic groups had lower body weights and tail lengths as well as higher hematocrits, right ventricular systolic pressures, and right heart weights. The hypoxic …

Reinforcement Learning-Based Demand Response Management In Smart Grid Systems With Prosumers, Jenilee Jao

Electrical and Computer Engineering ETDs

In this thesis, we introduce a reinforcement learning-based price-driven Demand Response Management (DRM) mechanism in smart grid systems consisting of prosumers. Our proposed approach accounts for the prosumers behavioral characteristics and models the emerging interactions among all the involved actors in the smart grid system, i.e., prosumers, Energy Management System (EMS) and utility companies. In particular, an off-policy reinforcement learning is introduced enabling the EMS to determine the optimal price that should be announced to the prosumers on an hourly-basis towards minimizing the overall systems cost. In this process, the utility companies hourly-based wholesale price and the prosumers energy generation …

Effectiveness And Safety Of Direct Oral Anticoagulants Among Patients With Non-Valvular Atrial Fibrillation And Multimorbidity, Amol Dhamane, Mauricio Ferri, Allison V. Keshishian, Cristina Russ, Nipun Atreja, Cynthia Gutierrez, Birol Emir, Huseyin Yuce, Manuela Di Fusco

Publications and Research

Introduction

In the USA, there is a steady rise of atrial fibrillation due to the aging population with increased morbidity. This study evaluated the risk of stroke/systemic embolism (S/SE) and major bleeding (MB) among elderly patients with non-valvular atrial fibrillation (NVAF) and multimorbidity prescribed direct oral anticoagulants (DOACs).

Methods

Using the CMS Medicare database, a retrospective observational study of adult patients with NVAF and multimorbidity who initiated apixaban, dabigatran, or rivaroxaban from January 1, 2012 to December 31, 2017 was conducted. High multimorbidity was classified as having ≥ 6 comorbidities. Cox proportional hazard models were used to evaluate the hazard …

Inhibition Of Rad18 By Arsenic, Lindsay B. Volk

Biomedical Sciences ETDs

Arsenite exposure leads to the retention of UV-induced DNA damage, thus burdening translesion synthesis (TLS). Rad18 is an essential factor in initiating TLS through PCNA monoubiquitination and is implicated in homologous recombination. It contains two functionally and structurally distinct zinc fingers that are potential targets for arsenite binding. Results from this study reveal arsenite binding to both zinc fingers of Rad18 and a corresponding loss of domain function. Importantly, arsenite inhibited Rad18 RING-dependent PCNA monoubiquitination and polymerase eta recruitment to DNA damage. Further analysis demonstrated multiple effects of arsenite, including the reduction in the nuclear localization and UV-induced chromatin recruitment …

Ela High School Teacher Beliefs About Academic Language Learning, Wendy Aro

Doctorate in Education

The enrollment of English learners (ELs) in K-12 schools in the United States continues to surpass all other student groups reshaping U.S. public schools (National Center for Education Statistics, 2017). Research suggests while learning English, ELs fall behind academically, which can determine how long an EL remains in an English learner program (Wixom, 2014). Educators and leaders are faced with the challenges associated with EL education including professional development, retaining EL specialized teachers, and designing, implementing, and evaluating EL service models. Other challenges include ensuring EL access to grade-level content standards while simultaneously developing the language of the subject area. …

Lens: A Novel Image Processing-Based Approach For Low-Cost Segmentation Of Computed Tomography Scans Of Lungs, Monica Hinga

Computer Science ETDs

A staggering amount of data has been collected and analyzed since the beginning of the COVID-19 pandemic. Some of that data, however, particularly computed tomography (CT) scans of lungs, are difficult to analyze computationally. Segmentation of COVID-19 lesions provides researchers with insights into where lesions form, their volume, and in the case of time course data, how lesions grow as disease progresses. Spatial information, which has received little attention in the literature, has the potential to provide valuable insight to within-host viral and immune dynamics. Unfortunately, state-of-the-art supervised deep learning methods require labeled data, which can be prohibitively expensive to …