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2022

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Surficial Geologic Map Of The Big Clifty 7.5-Minute Quadrangle, Kentucky, Maxwell L. Hammond Iii, Antonia E. Bottoms, Ann Hislop, Matthew Massey, Michele Mchugh, Emily Morris Dec 2022

Surficial Geologic Map Of The Big Clifty 7.5-Minute Quadrangle, Kentucky, Maxwell L. Hammond Iii, Antonia E. Bottoms, Ann Hislop, Matthew Massey, Michele Mchugh, Emily Morris

Contract Reports--KGS

The Big Clifty 7.5-minute quadrangle is located south of Louisville and west of Elizabethtown along the boundary between Hardin and Grayson Counties. The quadrangle lies within the Mammoth Cave plateau of the Mississippian Plateau physiographic region (McDowell, 1986). Topography is characterized by a low relief plain sitting at elevations between 650 to 850 ft above sea level, which is dissected and incised by Rough River, Meeting Creek, Clifty Creek, and their tributaries to below 500 ft. Swadley (1962) mapped the bedrock geology of the quadrangle, which was later digitized by Conley (2002). Mississippian bedrock is exposed throughout the quadrangle and …


"Overture" (For Emmanuel), Katherine Gordon Dec 2022

"Overture" (For Emmanuel), Katherine Gordon

Theses and Dissertations

“Overture” (For Emmanuel) is a piece derived from twelve melodies from the composer’s original musical, Emmanuel. The piece is for full orchestra, and is five minutes and forty-seven seconds long.


Editorial: Sustainability Of Physical Activity Interventions And Public Health, Erica Y. Lau, Maureen C. Ashe, Sharon E. Taverno, Russell R. Pate Ph.D. Dec 2022

Editorial: Sustainability Of Physical Activity Interventions And Public Health, Erica Y. Lau, Maureen C. Ashe, Sharon E. Taverno, Russell R. Pate Ph.D.

Faculty Publications

No abstract provided.


Propensities By Grade Of Math Anxiety Levels K-12: Addressing Mathematics Dispositions And How Manipulatives May Help, Joseph M. Furner, Christine M. Higgins Dec 2022

Propensities By Grade Of Math Anxiety Levels K-12: Addressing Mathematics Dispositions And How Manipulatives May Help, Joseph M. Furner, Christine M. Higgins

Transformations

Math anxiety remains a critical issue affecting student performance and confidence across grade levels throughout the world today. This paper looks at the impact of math anxiety and how students’ dispositions toward math from a leadership perspective and the real hinderance for them as learners in life in a STEM world. The paper shares data from a K-12 school on math anxiety levels and offers insights from a school principal who has served K-12 levels where math anxiety and discomfort levels of math are seen across the spectrum. This paper provides much research and recommendations of best practices for teaching …


Using Cooperative Learning To Teach Mathematics To Help Promising Ell And All Students Develop Social Skills: A Case Study, Dr Joseph M. Furner Dec 2022

Using Cooperative Learning To Teach Mathematics To Help Promising Ell And All Students Develop Social Skills: A Case Study, Dr Joseph M. Furner

Transformations

This paper shares the story of Jung and how a gifted young student in mathematics learns social skills and shares knowledge and also helps to improve his own learning of the English language while sharing his understanding of mathematics with others. Students working together in math classrooms all benefit in many ways including language acquisition, problem solving, math achievement, social skills, cultural differences, and a shared sense of community in a classroom, when all working together for a goal in learning mathematics while also learning social skills so to fit in better within society. Cooperative learning plays a critical role …


Full Issue Dec 2022

Full Issue

Transformations

Volume 8 Issue 1, December 2022


Classical Mechanics, Mark D. Shattuck Dec 2022

Classical Mechanics, Mark D. Shattuck

Open Educational Resources

Syllabus for Classical Mechanics


Progressive Acceleration Of Insulin Exposure Over 7 Days Of Infusion Set Wear, Jasmin R. Kastner, Timothy S. Bailey, Poul Strange, Leon Shi, Keith A. Oberg, Paul J. Strasma, Jeffrey I. Joseph, Douglas B. Muchmore Dec 2022

Progressive Acceleration Of Insulin Exposure Over 7 Days Of Infusion Set Wear, Jasmin R. Kastner, Timothy S. Bailey, Poul Strange, Leon Shi, Keith A. Oberg, Paul J. Strasma, Jeffrey I. Joseph, Douglas B. Muchmore

Department of Anesthesiology Faculty Papers

Insulin exposure varies over 3 days of insulin infusion set (IIS) wear making day-to-day insulin dosing challenging for people with diabetes (PWD). Here we report insulin pharmacodynamic (PD) and pharmacokinetic (PK) data extending these observations to 7 days of IIS wear. PWD (A1C ≤8.5%, C-peptide tmax (P < 0.001), Cmax (P < 0.05), and mean residence time (P < 0.0001). Area under the insulin concentration curve (AUC0–300) declined by ∼24% from days 0 to 7 (P < 0.05). These results confirm/extend previous observations showing progressive acceleration of insulin exposure over IIS wear time. This may have implications for PWD and designers of closed-loop algorithms, although larger studies are necessary to confirm this. The study was registered in clinicaltrials.gov (NCT04398030).


Return To Recreational Sports Participation Following Rotator Cuff Repair In Adults Over 40 Years Of Age: Outcomes And Return To Play Analysis, John Hayden Sonnier, Gregory Connors, Michael P. Campbell, Matthew Sabitsky, Ryan W. Paul, Hayden E. Sando, William D. Emper, Steven B. Cohen, Michael G. Ciccotti, Fotios P. Tjoumakaris, Kevin B. Freedman Dec 2022

Return To Recreational Sports Participation Following Rotator Cuff Repair In Adults Over 40 Years Of Age: Outcomes And Return To Play Analysis, John Hayden Sonnier, Gregory Connors, Michael P. Campbell, Matthew Sabitsky, Ryan W. Paul, Hayden E. Sando, William D. Emper, Steven B. Cohen, Michael G. Ciccotti, Fotios P. Tjoumakaris, Kevin B. Freedman

Rothman Institute Papers

Background: Despite the high prevalence of rotator cuff (RTC) tears in older adults, there is limited literature evaluating the return to recreational sport after repair. The purpose of this study was (1) to assess the patient-reported outcomes and return to sport rates following rotator cuff repair in patients aged more than 40 years with minimum 2-year follow-up; (2) to compare baseline, preoperative and postoperative outcomes, and level of play following repair of self-reported athletes with nonathletes; and (3) to compare return to sport rates in overhead athletes compared to nonoverhead athletes. Methods: Patients undergoing arthroscopic rotator cuff repair between January …


Ticuna Ceramics Amidst The Expansion Of Illicit Coca: Rendering New Relations, Manuel Martín Brañas, Sydney M. Silverstein, Margarita Del Aguila Villacorta, Ricardo Zárate Gómez, Cecilia Núñez Pérez, Alonso Cándido Yumbato, Juan José Palacios Vega, Rosario Rodríguez Romaní Dec 2022

Ticuna Ceramics Amidst The Expansion Of Illicit Coca: Rendering New Relations, Manuel Martín Brañas, Sydney M. Silverstein, Margarita Del Aguila Villacorta, Ricardo Zárate Gómez, Cecilia Núñez Pérez, Alonso Cándido Yumbato, Juan José Palacios Vega, Rosario Rodríguez Romaní

Tipití: Journal of the Society for the Anthropology of Lowland South America

In Ticuna communities across Amazonia, ceramics are useful objects employed for cooking and storage. Their practical importance, however, does not describe the extent of their significance. In the following article, we consider Ticuna ceramics and ceramic-making practices as a means of studying the changes set in motion by the transformation of Ticuna ancestral lands in Peru’s lowland Amazonian region into zones of illicit coca cultivation. Drawing on mixed-methods ethnographic research, including participant observation, interviews, and a participatory film project focused on ceramic production, we evaluate contemporary practices of ceramic-making within three Peruvian Ticuna communities in the context of these transformations, …


Arnis-Based Exercise Program For Balance Control In Community-Dwelling Older Adults: Study Protocol For A Pilot Randomized Controlled Trial, Donald Lipardo, Donald Manlapaz, Vergel B. Orpilla, Jim Carlo S. Buan, Jasneer Tricia C. Arevalo, Jaisen Lluch F. Cortez, Kyrell Patrick Desquitado, Vianca Mae L. Geli, Jose Raphael L. Lacorte, Johna R. Masibay, Caitlin Joy A. Sanchez, Alyssa Denise B. Villanueva Dec 2022

Arnis-Based Exercise Program For Balance Control In Community-Dwelling Older Adults: Study Protocol For A Pilot Randomized Controlled Trial, Donald Lipardo, Donald Manlapaz, Vergel B. Orpilla, Jim Carlo S. Buan, Jasneer Tricia C. Arevalo, Jaisen Lluch F. Cortez, Kyrell Patrick Desquitado, Vianca Mae L. Geli, Jose Raphael L. Lacorte, Johna R. Masibay, Caitlin Joy A. Sanchez, Alyssa Denise B. Villanueva

Philippine Journal of Physical Therapy

Background: Aging causes impairment in balance and increases the prevalence of falls in older adults. Martial arts are now incorporated into exercise programs to improve balance. Arnis, a Filipino Martial Art, can improve the balance control of older adults.

Objectives: This study primarily aims to determine the effects of an Arnis-based exercise program on balance control of healthy community-dwelling older adults. This study also aims to describe its effect on older adults’ concerns about falling and lower limb functional strength.

Methods:This will be a single-blind, pilot randomized controlled trial. Participants will be randomly allocated to either the intervention or …


In Unh Bologna Program, Life Imitates Art, Dave Moore Dec 2022

In Unh Bologna Program, Life Imitates Art, Dave Moore

UNH Today Archive

No abstract provided.


Pathway To Paying Tribute, Keith Testa Dec 2022

Pathway To Paying Tribute, Keith Testa

UNH Today Archive

No abstract provided.


Menstrual Health Among Adolescents And Young Adults In Rural Haiti., Emily R. Rupe, Jonathan Rodean, Emily A. Hurley, Melissa K. Miller, Marie Daphnee Boncoeur, Abbey R. Masonbrink Dec 2022

Menstrual Health Among Adolescents And Young Adults In Rural Haiti., Emily R. Rupe, Jonathan Rodean, Emily A. Hurley, Melissa K. Miller, Marie Daphnee Boncoeur, Abbey R. Masonbrink

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Adolescent and young adult (AYA) females in low- and middle-income countries often face disparities in menstrual health (MH). Poor MH and lack of sexual and reproductive health education leads to school absenteeism, increasing risk for adverse psychosocial and educational outcomes. Further, disasters (e.g., earthquakes) are linked with unsafe living environments and sanitation facilities for women. We sought to describe MH perspectives and practices among AYAs in rural Haiti.

METHODS: We conducted a cross-sectional survey in two rural communities in Haiti. AYA females aged 14-24 years completed questions on demographics, the Menstrual Practice Needs Scale (36 items; MPNS-36) and the …


Ypfs Lessons Learned Oral History Project: An Interview With Jesper Berg, Maryann Haggerty, Salil Gupta Dec 2022

Ypfs Lessons Learned Oral History Project: An Interview With Jesper Berg, Maryann Haggerty, Salil Gupta

Documents

No abstract provided.


Women's Power In Hospital-Based Nursing: A Critical Qualitative Study, Kaitlyn C. George, Bret Lyman, Andy Pilarte Alcantara, Maya Stephenson Dec 2022

Women's Power In Hospital-Based Nursing: A Critical Qualitative Study, Kaitlyn C. George, Bret Lyman, Andy Pilarte Alcantara, Maya Stephenson

Faculty Publications

Aim: To understand the factors that affect power in hospital-based nursing and reveal how the female gender affects an individual's ability to feel empowered.

Design: Critical qualitative research design.

Method: Semi-structured interviews were conducted with nurses working in inpatient hospital settings in Utah and New Mexico. Data were collected from February to March 2022. Interviews were analysed using thematic analysis.

Results: Sixteen participants were interviewed. Six themes were identified from the data, four of which related to nurses' power at work, and two of which specifically related to how gender affects a nurse's ability to use power and feel empowered. …


Mutually Intelligible Principles?, Andrew J. Ziaja Dec 2022

Mutually Intelligible Principles?, Andrew J. Ziaja

Pace Law Review

Are the nondelegation, major questions, and political question doctrines mutually intelligible? This article asks whether there is more than superficial resemblance between the nondelegation, major questions, and political question concepts in Wayman v. Southard, 23 U.S. (10 Wheat.) 1 (1825), an early nondelegation case that has become focal in recent nondelegation and major questions scholarship and jurisprudence. I argue that the nondelegation and political question doctrines do interact conceptually in Wayman, though not as current proponents of the nondelegation doctrine on the Supreme Court seem to understand it. The major questions doctrine by contrast conscripts the nondelegation …


2022 Quality Assessment And Performance Improvement Strategy, Tennessee. Division Of Tenncare. Dec 2022

2022 Quality Assessment And Performance Improvement Strategy, Tennessee. Division Of Tenncare.

TennCare Additional Reports

No abstract provided.


The Effect Of Allophonic Variability On L2 Contrast Perception: Evidence From Perception Of English Vowels, Alexis Zhou, Olga Dmitrieva, Daniel J. Olson Dec 2022

The Effect Of Allophonic Variability On L2 Contrast Perception: Evidence From Perception Of English Vowels, Alexis Zhou, Olga Dmitrieva, Daniel J. Olson

Purdue University Libraries Open Access Publishing Fund

Current frameworks of L2 phonetic acquisition remain largely underspecified with respect to the role of L1 allophonic variability in acquisition. Examining the role of L1 allophonic variability, the current study compared the perceptual discrimination of English /i-I/ and /E-æ/ by L1 Korean and L1 Mandarin speakers. Korean and Mandarin vowel inventories differ in that Mandarin employs significantly greater allophonic variation of the mid-region /E/ vowel. Results demonstrated worse perceptual accuracy by L1 Mandarin speakers for the /E-æ/ contrast than L1 Korean speakers. These results suggest that both L1 phonemic inventories and allophonic variation play a role in L2 phonetic acquisition.


Community Engagement For Birth Preparedness And Complication Readiness In The Community Level Interventions For Pre-Eclampsia (Clip) Trial In India: A Mixed-Method Evaluation, Avinash Kavi, Mai-Lei Woo Kinshella, Umesh Y Ramadurg, Umesh Charantimath, Geetanjali M Katageri, Chandrashekhar C Karadiguddi, Narayan V Honnungar, Shashidhar G Bannale, Geetanjali I Mungarwadi, Jeffrey N Bone, Marianne Vidler, Laura Magee, Ashalata Mallapur, Shivaprasad S Goudar, Mrutyunjaya Bellad, Richard Derman, Peter Von Dadelszen, The Clip India Working Group Dec 2022

Community Engagement For Birth Preparedness And Complication Readiness In The Community Level Interventions For Pre-Eclampsia (Clip) Trial In India: A Mixed-Method Evaluation, Avinash Kavi, Mai-Lei Woo Kinshella, Umesh Y Ramadurg, Umesh Charantimath, Geetanjali M Katageri, Chandrashekhar C Karadiguddi, Narayan V Honnungar, Shashidhar G Bannale, Geetanjali I Mungarwadi, Jeffrey N Bone, Marianne Vidler, Laura Magee, Ashalata Mallapur, Shivaprasad S Goudar, Mrutyunjaya Bellad, Richard Derman, Peter Von Dadelszen, The Clip India Working Group

Department of Obstetrics and Gynecology Faculty Papers

Objective: To describe the process of community engagement (CE) in northern Karnataka, India and its impact on pre-eclampsia knowledge, birth preparedness and complication readiness, pregnancy-related care seeking and maternal morbidity.

Design: This study was a secondary analysis of a cluster randomised trial of Community Level Interventions for Pre-eclampsia (CLIP). A total of 12 clusters based on primary health centre catchment areas were randomised to intervention or control. CE was conducted in intervention clusters. CE attendance was summarised according to participant group using both quantitative and qualitative assessment. Pre-eclampsia knowledge, birth preparedness, health services engagement and perinatal outcomes was evaluated within …


Patient Trust In Physicians Matters-Understanding The Role Of A Mobile Patient Education System And Patient-Physician Communication In Improving Patient Adherence Behavior: Field Study, Dezhi Wu, Paul Benjamin Lowry, Dongsong Zhang, Youyou Tao Dec 2022

Patient Trust In Physicians Matters-Understanding The Role Of A Mobile Patient Education System And Patient-Physician Communication In Improving Patient Adherence Behavior: Field Study, Dezhi Wu, Paul Benjamin Lowry, Dongsong Zhang, Youyou Tao

Publications

BACKGROUND: The ultimate goal of any prescribed medical therapy is to achieve desired outcomes of patient care. However, patient nonadherence has long been a major problem detrimental to patient health and, thus, is a concern for all health care providers. Moreover, nonadherence is extremely costly for global medical systems because of unnecessary complications and expenses. Traditional patient education programs often serve as an intervention tool to increase patients' self-care awareness, disease knowledge, and motivation to change patient behaviors for better adherence. Patient trust in physicians, patient-physician relationships, and quality of communication have also been identified as critical factors influencing patient …


On The Bookshelf And Streaming, Susan Dumais Dec 2022

On The Bookshelf And Streaming, Susan Dumais

UNH Today Archive

No abstract provided.


Does Receiving A Sars-Cov-2 Antibody Test Result Change Covid-19 Protective Behaviors? Testing Risk Compensation In Undergraduate Students With A Randomized Controlled Trial, Christina Ludema, Molly S Rosenberg, Jonathan T Macy, Sina Kianersi, Maya Luetke, Chen Chen, Lilian Golzarri-Arroyo, Erin Ables, Kevin Maki, David B Allison Dec 2022

Does Receiving A Sars-Cov-2 Antibody Test Result Change Covid-19 Protective Behaviors? Testing Risk Compensation In Undergraduate Students With A Randomized Controlled Trial, Christina Ludema, Molly S Rosenberg, Jonathan T Macy, Sina Kianersi, Maya Luetke, Chen Chen, Lilian Golzarri-Arroyo, Erin Ables, Kevin Maki, David B Allison

Children’s Nutrition Research Center Staff Publications

Background: Risk compensation, or matching behavior to a perceived level of acceptable risk, can blunt the effectiveness of public health interventions. One area of possible risk compensation during the SARS-CoV-2 pandemic is antibody testing. While antibody tests are imperfect measures of immunity, results may influence risk perception and individual preventive actions. We conducted a randomized control trial to assess whether receiving antibody test results changed SARS-CoV-2 protective behaviors.

Purpose: Assess whether objective information about antibody status, particularly for those who are antibody negative and likely still susceptible to SARS-CoV-2 infection, increases protective behaviors. Secondarily, assess whether a positive antibody test …


A Flexible-Hazards Cure Model With Application To Patients With Soft Tissue Sarcoma, Can Xie, Xuelin Huang, Ruosha Li, Peter W T Pisters Dec 2022

A Flexible-Hazards Cure Model With Application To Patients With Soft Tissue Sarcoma, Can Xie, Xuelin Huang, Ruosha Li, Peter W T Pisters

Faculty, Staff and Student Publications

In medical research, it is often of great interest to have an accurate estimation of cure rates by different treatment options and for different patient groups. If the follow-up time is sufficiently long and the sample size is large, the proportion of cured patients will make the Kaplan-Meier estimator of survival function have a flat plateau at its tail, whose value indicates the overall cure rate. However, it may be difficult to estimate and compare the cure rates for all the subsets of interest in this way, due to the limit of sample sizes and curse of dimensionality. In the …


Barriers For Small Businesses To Adopt Sustainable Practices In The Sioux Falls Area, Meredith King Dec 2022

Barriers For Small Businesses To Adopt Sustainable Practices In The Sioux Falls Area, Meredith King

Honors Thesis

Sustainability is a broad concept that encompasses environmental, social, and economic factors to meet current and future needs. Many individuals and large businesses are becoming conscious of the effects they have on the planet and the people around them. However, despite the financial benefits and positive publicity of environmentalism, many businesses are not adopting sustainable practices. This study interviewed local business owners to answer the question “What are the main reasons that small businesses in the Sioux Falls area of South Dakota do or do not adopt sustainable practices that benefit the environment and the community?” Five business owners were …


Correlations Between Complex Human Phenotypes Vary By Genetic Background, Gender, And Environment, Michael Elgart, Matthew O Goodman, Carmen Isasi, Han Chen, Alanna C Morrison, Paul S De Vries, Huichun Xu, Ani W Manichaikul, Xiuqing Guo, Nora Franceschini, Bruce M Psaty, Stephen S Rich, Jerome I Rotter, Donald M Lloyd-Jones, Myriam Fornage, Adolfo Correa, Nancy L Heard-Costa, Ramachandran S Vasan, Ryan Hernandez, Robert C Kaplan, Susan Redline, Tamar Sofer Dec 2022

Correlations Between Complex Human Phenotypes Vary By Genetic Background, Gender, And Environment, Michael Elgart, Matthew O Goodman, Carmen Isasi, Han Chen, Alanna C Morrison, Paul S De Vries, Huichun Xu, Ani W Manichaikul, Xiuqing Guo, Nora Franceschini, Bruce M Psaty, Stephen S Rich, Jerome I Rotter, Donald M Lloyd-Jones, Myriam Fornage, Adolfo Correa, Nancy L Heard-Costa, Ramachandran S Vasan, Ryan Hernandez, Robert C Kaplan, Susan Redline, Tamar Sofer

Faculty, Staff and Student Publications

We develop a closed-form Haseman-Elston estimator for genetic and environmental correlation coefficients between complex phenotypes, which we term HEc, that is as precise as GCTA yet ∼20× faster. We estimate genetic and environmental correlations between over 7,000 phenotype pairs in subgroups from the Trans-Omics in Precision Medicine (TOPMed) program. We demonstrate substantial differences in both heritabilities and genetic correlations for multiple phenotypes and phenotype pairs between individuals of self-reported Black, Hispanic/Latino, and White backgrounds. We similarly observe differences in many of the genetic and environmental correlations between genders. To estimate the contribution of genetics to the observed phenotypic correlation, we …


Rhetoric And Affect In Undergraduate Research: A Diary Study, Kristine Johnson, J. Michael Rifenburg Dec 2022

Rhetoric And Affect In Undergraduate Research: A Diary Study, Kristine Johnson, J. Michael Rifenburg

University Faculty Publications and Creative Works

In this article, we examine undergraduate research as a site of rhetorical development by listening to undergraduate researchers narrate and reflect upon their work as it unfolds. We draw from diary entries and follow-up interviews with eighteen undergraduate researchers at two different institutions, analyzing the rhetorical and affective elements of undergraduate research. Connecting undergraduate research with the concept of meaningful writing, we conclude by offering recommendations for teachers, mentors, and administrators.


Emergency Remote Teaching Versus Planned Remote Teaching: Narrowing The Gap With Targeted Professional Development, Bonnie J. Covelli, Sudipta Roy Dec 2022

Emergency Remote Teaching Versus Planned Remote Teaching: Narrowing The Gap With Targeted Professional Development, Bonnie J. Covelli, Sudipta Roy

Higher Learning Research Communications

Objectives: This study reviews faculty members’ comfort level with remote teaching in the Fall 2020 semester to evaluate the effectiveness of the professional development workshops.

Method: Using survey research, we examined professional development activities and subsequent comfort level and ease of adjustment with remote teaching in Fall 2020.

Results: Following the training, faculty reported high planned usage of various online teaching tools and great comfort with using them. The data reveals some differences between part-time and full-time faculty members.

Conclusions: The experience gained in the emergency semester, combined with the targeted professional development workshops offered eased the stress of planned …


In-Depth Analysis Of Alternative Splicing Landscape In Multiple Myeloma And Potential Role Of Dysregulated Splicing Factors, Anil Aktas Samur, Mariateresa Fulciniti, Herve Avet-Loiseau, Michael A Lopez, Sanika Derebail, Jill Corre, Stephane Minvielle, Florence Magrangeas, Philippe Moreau, Kenneth C Anderson, Giovanni Parmigiani, Mehmet K Samur, Nikhil C Munshi Dec 2022

In-Depth Analysis Of Alternative Splicing Landscape In Multiple Myeloma And Potential Role Of Dysregulated Splicing Factors, Anil Aktas Samur, Mariateresa Fulciniti, Herve Avet-Loiseau, Michael A Lopez, Sanika Derebail, Jill Corre, Stephane Minvielle, Florence Magrangeas, Philippe Moreau, Kenneth C Anderson, Giovanni Parmigiani, Mehmet K Samur, Nikhil C Munshi

Faculty, Staff and Student Publications

Splicing changes are common in cancer and are associated with dysregulated splicing factors. Here, we analyzed RNA-seq data from 323 newly diagnosed multiple myeloma (MM) patients and described the alternative splicing (AS) landscape. We observed a large number of splicing pattern changes in MM cells compared to normal plasma cells (NPC). The most common events were alterations of mutually exclusive exons and exon skipping. Most of these events were observed in the absence of overall changes in gene expression and often impacted the coding potential of the alternatively spliced genes. To understand the molecular mechanisms driving frequent aberrant AS, we …


Surface Modification Of 3d Printed Microfluidic Devices For Controlled Wetting In Two-Phase Flow, Chandler A. Warr, Nicole G. Crawford, Gregory P. Nordin, William G. Pitt Dec 2022

Surface Modification Of 3d Printed Microfluidic Devices For Controlled Wetting In Two-Phase Flow, Chandler A. Warr, Nicole G. Crawford, Gregory P. Nordin, William G. Pitt

Faculty Publications

Microfluidic devices (MFDs) printed in 3-D geometry using digital light projection to polymerize monomers often have surfaces that are not as hydrophobic as MFDs made from polydimethylsiloxane. Droplet microfluidics in these types of devices are subject to droplet adhesion and aqueous spreading on less hydrophobic MFD surfaces. We have developed a post-processing technique using hydrophobic monomers that renders the surfaces of these devices much more hydrophobic. The technique is fast and easy, and involves flowing monomer without initiator into the channels and then exposing the entire device to UV light that generates radicals from the initiator molecules remaining in the …