Digital Commons Network^™

Identification Of Lung Cancer Drivers By Comparison Of The Observed And The Expected Numbers Of Missense And Nonsense Mutations In Individual Human Genes, Olga Y Gorlova, Marek Kimmel, Spiridon Tsavachidis, Christopher I Amos, Ivan P Gorlov

Faculty, Staff and Students Publications

Largely, cancer development is driven by acquisition and positive selection of somatic mutations that increase proliferation and survival of tumor cells. As a result, genes related to cancer development tend to have an excess of somatic mutations in them. An excess of missense and/or nonsense mutations in a gene is an indicator of its cancer relevance. To identify genes with an excess of potentially functional missense or nonsense mutations one needs to compare the observed and expected numbers of mutations in the gene. We estimated the expected numbers of missense and nonsense mutations in individual human genes using (i) the …

Stat6 Suppression Prevents Bleomycin-Induced Dermal Fibrosis, Hua Sun, Ashish Damania, Megan L Mair, Eniola Otukoya, Yi-Dong Li, Katherine Polsky, Yuying Zeng, Jeremiah A Alt, Martin J Citardi, David B Corry, Amber U Luong, John Morgan Knight

Faculty, Staff and Student Publications

Unified airway disease, including concurrent asthma and chronic rhinosinusitis (CRS), is a common, but poorly understood disorder with no curative treatment options. To establish a murine model of chronic unified eosinophilic airway inflammation, mice were challenged with Aspergillus niger, and sinonasal mucosa and lung tissue were evaluated by immunohistochemistry, flow cytometry, and gene expression. Inhalation of A niger conidia resulted in a Th2-biased lung and sinus inflammation that typifies allergic asthma and CRS. Gene network and pathway analysis correlated with human disease with upregulation of not only the JAK-STAT and helper T-cell pathways, but also less expected pathways governing …

Advancements In The Quest To Map, Monitor, And Manipulate Neural Circuitry, Jessica L Swanson, Pey-Shyuan Chin, Juan M Romero, Snigdha Srivastava, Joshua Ortiz-Guzman, Patrick J Hunt, Benjamin R Arenkiel

Duncan NRI Faculty and Staff Publications

Neural circuits and the cells that comprise them represent the functional units of the brain. Circuits relay and process sensory information, maintain homeostasis, drive behaviors, and facilitate cognitive functions such as learning and memory. Creating a functionally-precise map of the mammalian brain requires anatomically tracing neural circuits, monitoring their activity patterns, and manipulating their activity to infer function. Advancements in cell-type-specific genetic tools allow interrogation of neural circuits with increased precision. This review provides a broad overview of recombination-based and activity-driven genetic targeting approaches, contemporary viral tracing strategies, electrophysiological recording methods, newly developed calcium, and voltage indicators, and neurotransmitter/neuropeptide biosensors …

Clinical Reasoning Education In The Clerkship Years: A Cross-Disciplinary National Needs Assessment, Jonathan G Gold, Christopher L Knight, Jennifer G Christner, Christopher E Mooney, David E Manthey, Valerie J Lang

Faculty, Staff and Students Publications

BACKGROUND: Improving clinical reasoning education has been identified as an important strategy to reduce diagnostic error-an important cause of adverse patient outcomes. Clinical reasoning is fundamental to each specialty, yet the extent to which explicit instruction in clinical reasoning occurs across specialties in the clerkship years remains unclear.

METHOD: The Alliance for Clinical Education (ACE) Clinical Reasoning Workgroup and the Directors of Clinical Skills Courses (DOCS) Clinical Reasoning Workgroup collaborated to develop a clinical reasoning needs assessment survey. The survey questionnaire covered seven common clinical reasoning topics including illness scripts, semantic qualifiers, cognitive biases and dual process theory. Questionnaires were …

Metastatic Insulinoma Presenting With Postprandial Hypoglycemia, Monique Debrah Maher, Dimpi Nitin Desai, Mandeep Bajaj

Faculty, Staff and Students Publications

BACKGROUND/OBJECTIVE: Patients with an insulinoma, a type of pancreatic neuroendocrine tumor, typically present with fasting hypoglycemia but can rarely present exclusively with postprandial hypoglycemia.

CASE REPORT: A 69-year-old man presented with episodes of postprandial blurry vision, sweating, and confusion for the last 2 years that were becoming more frequent over the last several weeks. Home blood glucose measurements revealed postprandial hypoglycemia (glucose level, 45-70 mg/dL), and symptoms were consistent with the Whipple triad. Continuous glucose monitoring revealed only postprandial hypoglycemia within 2 hours following meals. An outpatient fast was conducted with detectable insulin (6 μIU/mL) and C-peptide (2.0 ng/mL) levels …

Preliminary Report On The 2021 Season Of Excavations At As-Khirbat Safra, Paul Gregor, Paul Ray, Talmadge Gerald, Trisha Broy

Faculty Publications

No abstract provided.

What Works To Improve Outcomes For Kenya’S Adolescent Girls?, Population Council

Adolescents and Young People

The Adolescent Girls Initiative-Kenya is a study that evaluates the long-term impact of a multi-sectoral intervention targeted at adolescent girls aged 11 to 15 years from Kibera and rural Wajir. The intervention consisted of four different components: a community-based violence prevention program, an education conditional cash transfer (CCT), health-focused girls' empowerment clubs, and wealth creation for girls via financial education and savings activities. This brief looks at the impact of the two-year program in Wajir County four years after it ended.

Surprising Grace, Jiří Moskala

Faculty Publications

No abstract provided.

Earthquake! We Were Crying Everyday! The Resilience Of Haitian Survivors In Academia, Luceandy Tooley

All-Inclusive List of Electronic Theses and Dissertations

The purpose of this study aimed to explore the experiences of Haitian immigrant college students who sought higher education attainment in the aftermath of the 2010 earthquake in the United States. This study focused on understanding participants migration experience, immigration policy, and their decision to pursue a college degree in the United States after surviving the 2010 earthquake. The four themes that emerged from the data were: barriers, self-preservation, self-motivation, and support. The findings demonstrated that participants felt supported by family and friends and were heavily involved in college groups and organizations. Haitian earthquake survivors revealed how resilient and hard-working …

Exploring Double Consciousness For Black Students In K-12 Settings, Virgil Khalid Griffin

All-Inclusive List of Electronic Theses and Dissertations

The purpose of this study was to learn about double consciousness with Black students in K–12settings. The research questions considered how experiences with race and racism altered Blackstudents perspectives on race and racial identity. Moreover, the research questions referencedthe usage of double consciousness for Black students as they navigated K–12 settings. Blackstudents were recruited from colleges and universities in Indiana. Each participant had to beBlack American, between the ages of 18–24, and have experienced all learning in Americanschools. Participants in the study represented various walks of life and educational backgrounds.Semi-structured, one-on-one interviews were completed for each participant. One-on-oneinterviews were intentional. …

Barriers And Facilitators To Diabetes Screening And Prevention After A Pregnancy Complicated By Gestational Diabetes, Drishti D. Sinha, Roxann C. Williams, Laura N. Hollar, Hannah R. Lucas, Bethany Johnson-Javois, Heidi B. Miller, Amanda Stoermer, Graham A. Colditz, Aimee S. James, Cynthia J. Herrick

2020-Current year OA Pubs

OBJECTIVE: Gestational diabetes mellitus (GDM) is increasing in the United States, with higher rates among minoritized racial and ethnic populations and lower income populations. GDM increases risk for type 2 diabetes (T2DM), and postpartum diabetes screening and prevention are imperative. This qualitative study examines barriers and facilitators to postpartum T2DM screening and prevention among non-privately insured individuals with a history of GDM in a state prior to Medicaid expansion.

METHODS: Thirty-six non-privately insured women with a history of GDM completed semi-structured interviews. Four focus groups and seven interviews were conducted with 30 nurse practitioners, physicians, physician assistants, nurses and registered …

“My Background Is A Little Bit More Than What I Am Now", 21cleo Research Team

21CLEO Research Project Blog Posts

No abstract provided.

Learning And Job Advancement: Insights From A Follow-Up Questionnaire, 21cleo Research Team

21CLEO Research Project Blog Posts

Over the course of our research project, we were able to interview 27 working Learners employed in frontline service work in the US. Our plans to expand this data set and conduct in-person follow-up interviews was disrupted by the COVID-19 pandemic. In order to have some sense of what our participants' education, work, and lived experiences were like in the year after our interviews, we sent a follow-up questionnaire to all 27 in the summer of 2021 and received responses from 13 individuals. It was important for us to reconnect with these learners after more than a year of societal …

Complexifying Paid Learning, 21cleo Research Team

21CLEO Research Project Blog Posts

No abstract provided.

Missing Persona: Insights From Research Partners, 21cleo Research Team

21CLEO Research Project Blog Posts

No abstract provided.

Limitations Of Our Working Learner Persona: Insights From Research Partners, 21cleo Research Team

21CLEO Research Project Blog Posts

No abstract provided.

Conspiracy Theories Through A Cross-Cultural Lens, Roland Imhoff

Online Readings in Psychology and Culture

Conspiracy beliefs and an overarching conspiracy mentality binding them together are hot topics in psychology, not the least due to potential societal costs that are associated with them. Despite anecdotal evidence supporting the ubiquity of such beliefs across the globe, very little research has systematically explored cross-cultural differences, let alone tested theory-based hypotheses about such differences. The present paper highlights important methodological and theoretical considerations in developing a sound research program in predictors of country-level variations in conspiracy endorsement.

An Exploration Of Elementary School Teachers’ Experiences With Implementing The Response To Intervention Model Remotely During The Covid-19 Pandemic, Shani Nicole Challenor

Selected Full Text Dissertations, 2011-

The COVID-19 pandemic quickly removed teachers from their classroom, and they were forced to enter the world of distance learning. The presented research is unique and ground-breaking as this is the first pandemic in over one-hundred years to this magnitude. This dissertation assesses the impact that the 2020 COVID-19 pandemic had on a diverse group of Nassau County elementary school teachers as they implemented the Response to Intervention (RTI) framework remotely. The Interpretive Phenomenological Analysis (IPA) method was used to reveal the insights of elementary school teachers’ experiences with delivering the RTI model remotely during the coronavirus pandemic. The IPA …

Probing With Noise: Unpicking The Warp And Weft Of Taxonomic And Thematic Meaning Representations In Static And Contextual Embeddings, Filip Klubička

Doctoral

The semantic relatedness of words has two key dimensions: it can be based on taxonomic information or thematic, co-occurrence-based information. These are captured by different language resources—taxonomies and natural corpora—from which we can build different computational meaning representations that are able to reflect these relationships. Vector representations are arguably the most popular meaning representations in NLP, encoding information in a shared multidimensional semantic space and allowing for distances between points to reflect relatedness between items that populate the space. Improving our understanding of how different types of linguistic information are encoded in vector space can provide valuable insights to the …

Western Herbalism: What Drives Individuals Within Rhode Island To Study This Ancient Healing Modality?, Kyla Shea

Student Publications

People globally rely on herbal practices as their main form of healing, yet few people in the West understand how to properly identify and effectively use herbs. This loss of knowledge regarding traditional healing practices was done so intentionally during enslavement and colonization, resulting in exploitation and misinterpretation of herbal practices. By reclaiming this knowledge, it is not only a way to improve the health of communities and the land, but it is also a way of reclaiming ancestral traditions and connection with oneself. Furthermore, this research paper explores the complexities of Western herbalism and determines what drives individuals within …

Ai Governance In The Financial Industry, Robin C. Feldman, Kara Stein

Faculty Scholarship

Legal regimes in the United States generally conceptualize obligations as attaching along one of two pathways: through the entity or the individual. Although these dual conceptualizations made sense in an ordinary pre-modem world, they no longer capture the financial system land­ scape, now that artificial intelligence has entered the scene. Neither person nor entity, artificial intelligence is an activity or a capacity, something that mediates relations between individuals and entities. And whether we like it or not, artificial intelligence has already reshaped financial markets. From Robinhood, to the Flash Crash, to Twitter's Hash Crash, to the Knight Capital incident, each …

Rulemaking's Second Founding, Richard L. Marcus

Faculty Scholarship

No abstract provided.

The House Always Wins: Doctrine And Animus In California’S Covid-19 Prison Litigation, Hadar Aviram

Faculty Scholarship

No abstract provided.

Pursuing Citizenship During Covid-19, Ming Hsu Chen

Faculty Scholarship

No abstract provided.

A Health Justice Response To School Discipline And Policing, Thalia Gonzalez, Alexis Etow, Cesar De La Vega

Faculty Scholarship

Inequities in school discipline and policing have been long documented by researchers and advocates. Longitudinal data is clear that Black, Indigenous, people of color (BIPOC) students are punished and policed at higher rates than their white classmates. For students who have disabilities, especially those with intersectional identities, the impact of school discipline and policing is amplified, with disparities existing at some of the highest rates across multiple categories. And this disproportionality has not diminished during short- and long-term school closures resulting from the COVID-19 pandemic. In fact, schools have employed new models of exclusion in the pandemic setting that operate …

The Death Of Law, Ugo Mattei

Faculty Scholarship

This is a talk about the decline and fall of constitutional law, an over-arching characteristic of the new millennium. I focus on the period from the end of the Cold War—once described as the end of history—to what I call the “Second Cold War” beginning in the second decade of this century and having escalated in the proxy war in Ukraine. The Second Cold War is also characterized by an aborted cooptation of China through the World Trade Organization (to tame China’s seemingly unstoppable ascension to global supremacy) as well as a state of per-manent emergency.

Brains Without Money: Poverty As Disabling, Emily R. Murphy

Faculty Scholarship

e United States has long treated poverty and disability as separate legal and social categories, a division grounded in widespread assumptions about the “deserving” and “undeserving” poor. In the case of disability, individuals generally are not thought to be morally responsible for their disadvantage, whereas in the case of poverty, individuals are assumed to be at fault for their disadvantage and are therefore less deserving of aid. This Article argues that recent advances in brain and behavioral science undermine the factual basis for those assumptions. Poverty inhibits brain development during childhood and, later in life, adversely affects cognitive capacities that …

Toward A Broader Vision Of Lawyering, Ascanio Piomelli

Faculty Scholarship

No abstract provided.

Patents As Property For The Takings, Robin Feldman

Faculty Scholarship

The Fifth Amendment’s Compensation Clause contains only a few simple words: “nor shall private property be taken for public use without just compensation.” Yet these simple words have confounded legal minds for over 200 years, and as Congress has contemplated various patent law reforms in recent decades, the specter of the Fifth Amendment looms on the horizon. Conventionally, commentators and judges break down the clause into a few diferent components, each of which has generated a voluminous body of caselaw and corresponding scholarly inquiry. First, there is the question of takings: How does one know if something has been “taken” …

Critical Race Feminism, Health, And Restorative Practices In Schools: Centering The Experiences Of Black And Latina Girls, Thalia Gonzalez, Rebecca Epstein

Faculty Scholarship

Restorative practices (RP) in K-12 schools in the United States have grown exponentially since the early 1990s. Developing against a backdrop of systemic racism, RP has become embedded in educa- tion practice and policy to counteract the harmful and persistent patterns of disparities in school discipline experienced by students of color. Within this legal, social, and political context, the em- pirical evidence that has been gathered on school-based restora- tive justice has framed and named RP as a behavioral interven- tion aimed at reducing discipline incidents—that is, an “alternative” to punitive and exclusionary practices. While this view of RP is …