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Design And Synthesis Of Purine Based Neuroprotectors And Novel Synthetic Methods For The Trifluoromethylation Of Aldehyde Hydrazones, Puspa Aryal

Doctoral Dissertations

"Purine-derived compounds are widely investigated as cyclin-dependent kinase inhibitors that have broad applications in the design of pharmaceuticals for treating diseases, such as diabetes, atherosclerosis, and cancers. Towards the goal of effective AGE-inhibitors, and neuroprotector compounds we have synthesized a series of novel purine-based triazoles and investigated their neuroprotective effects, using SHSY-3Y human neuroblastoma cell line. Through these studies, we have identified purine-based neuroprotector compounds that favorably modulate oxidative stress induced by the Fenton reaction-generated reactive oxygen species (ROS).

The C(sp²−H)-trifluoromethylation of hydrazones would give access to the αtrifluoromethylated hydrazones that can serve as intermediates in the synthesis …

Multifunctional Behaviors Of Two-Dimensional Materials And Their Composites, Yanxiao Li

Doctoral Dissertations

"Two-dimensional (2D) materials, including graphene, transition metal carbides or nitrides (TMC/Ns), have rich surface chemistry, superb electrical and mechanical properties. These unique properties make them ideal for multifunctional devices. Among them, we focused on graphene and TMC/Ns (i.e., MXenes), as well as their composites. Unlike the well-known graphene, MXenes, are relatively new and typically synthesized by the selective etching of the “A” layers from the layered carbides and /or nitrides known as MAX phases, which introduce MXenes with rich terminal groups (e.g. -O-, -OH, -F).

During my Ph.D. study, firstly, the adhesive and frictional behaviors, which are related to successful …

Multi-Stage Multi-Market Optimal Bidding Strategy In Electricity Markets, Hossein Mehdipourpicha

Doctoral Dissertations

"Restructuring of power industry created the competitive situations for different MPs through designing appropriate electricity markets. Typically, in pool-based electricity markets, MPs submit their offers, and ISO clears the market and notifies MPs of the cleared power amounts and market prices. In this situation, designing an effective bidding strategy for MPs who seek to maximize their profits has thus become one of the crucial yet difficult tasks that still need further exploration. The majority of recent studies overlooked this problem for the purely financial players. Therefore, designing an efficient strategy for virtual bidder in the pool-based electricity markets is studied …

Laterally Heterogeneous Seismic Anisotropy Investigated By Shear Wave Splitting Analyses, Yan Jia

Doctoral Dissertations

"Numerous geophysical studies suggest that seismic anisotropy is a nearly ubiquitous property of the Earth’s crust and upper mantle. In this study, we utilize the shear wave splitting technique to investigate the piercing-point-dependent azimuthal anisotropy beneath the northeastern edge of the Sichuan Basin in central China, and the spatial and temporal variations of anisotropy near the 2019 M7.1 Ridgecrest earthquake in California, respectively. A clear back azimuthal dependence of the splitting parameters and the lack of a 90° or 180° periodicity of azimuthal variation in the observed fast orientations provide strong evidence for the existence of piercing-point-dependent anisotropy beneath the …

Groundwater Withdrawal Estimation Using Integrated Remote Sensing Products And Machine Learning, Sayantan Majumdar

Doctoral Dissertations

"The rising demands for water, food, and energy primarily driven by the increasing global population constitute a pressing issue worldwide. Therefore, the water-food-energy nexus plays a substantial role in developing globally applicable sustainable solutions. Recent technological advancements, including the earth observation programs using spaceborne remote sensing platforms, have enabled us to monitor various critical components affecting the globe. Groundwater, which comprises the world's 30% freshwater, is one such key component of the global water resources and supplies nearly half of the global drinking water.

Despite groundwater overdraft in many parts of the world, including the United States (US), there are …

Using Computational Methods To Optimize High Heat Flux Component Thermal Performance In Magnetic Confinement Fusion Reactor Research, Monica Gehrig

Doctoral Dissertations

"Heat transfer enhancement by means of internally modified geometries in tubes and channels is an important mechanism to improve the survivability of components in extreme high-heat flux environments. Various features such as ribs and fins are studied using computational fluid dynamics in both uniform and one-sided heating in tubes and rectangular channels respectively to determine the most effective geometries across a variety of different flow and heating conditions. This work examines heat transfer enhancement and rib geometry optimization to support experimental research for nuclear fusion applications. The project begins by designing and analyzing test sections supporting a helium flow loop …

Molten Steel Interactions With Tundish Linings And Refractory Glazes, Tyler Michael Richards

Doctoral Dissertations

"In the final stages of casting, molten steel is in contact with two main types of refractories: the working lining of the tundish used to serve as an intermediate vessel between the ladle and copper mold, and the various glazed carbon-bearing refractories used to control the flow of steel from the ladle to the tundish and from the tundish to the mold. If steel interacts with these refractories in such a way as to result in the formation of inclusions, it may be too late to remove them, leading to degradation of the steel’s mechanical properties. Understanding these interactions and …

Promoting Distributed Energy Deployment And Diffusion For Sustainable Civil Infrastructure Using Multi-Agent Based Modeling And Quantitative Analytics, Gasser Ali

Doctoral Dissertations

"Distributed Solar Generation (DSG) using small-scale Photo-Voltaic (PV) is an evolving technology with increasingly growing market penetration due to its significant benefits to consumers and broader power systems. DSG is sustainable, provides reliability, and is cost-effective where solar energy is abundant. However, the increasingly growing adoption of DSG creates uncertainties in forecasting electric power demand and market behavior. It also causes concerns of a “utility death spiral”. To this end, the goal of this research is to critically analyze the diffusion and benefits of DSG in the electric power infrastructure as a complex System-of-Systems (SoS). Specifically, this dissertation addresses the …

Mantle Flow And Transition Zone Discontinuities Beneath The Carribean Plate: Constraints From Shear Wave Splitting And Receiver Function Analyses, Tu Xue

Doctoral Dissertations

"Azimuthal anisotropy quantified by teleseismic SKS, SKKS, PKS (“XKS”) and local S wave splitting parameters is used to investigate lithospheric deformation and asthenospheric flow beneath the boundary zone of the North American and Caribbean plates and adjacent areas. A total of 4915 XKS and 1202 pairs of local S wave splitting parameters were obtained at 24 broad band seismic stations. The XKS observations can be divided into two groups based on the spatial distribution of the resulting fast polarization orientations. Those observed on the Caribbean Plate are mostly WNW-ESE which are roughly trench-parallel. In contrast, the fast orientations observed on …

Influences Of The Internal Residual On Combustion Instabilities In The Misfire And Partial Burn Regimes Of A Dilute Spark-Ignition Engine, Rachel Inez Stiffler

Doctoral Dissertations

"Dilution in spark-ignition (SI) engines can improve fuel consumption and reduce emissions; however, increased levels of dilution either from excess oxidizer or exhaust gas recirculation (EGR) causes combustion to become more strained and cycle-to-cycle variations increase. At high levels of dilution incomplete combustion events (i.e. misfires and partial burns) start to occur, which cause combustion instabilities and eventually a dilute limit is reached. It is known the combustion instabilities seen are primarily due to the feed-forward mechanism present in the residual gases, but it is still unknown what about the residual is influencing the dynamics under high levels of dilution …

Far-End Crosstalk Modeling And Prediction For High-Speed Pcb Design With Inhomogeneous Dielectric Layers (Idls), Yuanzhuo Liu

Doctoral Dissertations

"Far-end crosstalk (FEXT) noise is a critical factor that affects signal integrity performance in high-speed systems. The FEXT level is sensitive to the inhomogeneity of the dielectric layers in fabricated printed circuit boards (PCB). The stripline is laminated by multiple inhomogeneous dielectric layers (IDL). The dielectric layers of the stripline are laminated with epoxy resin and glass bundles. The dielectric permittivity of the epoxy resin and glass bundles are different, which causes the inhomogeneity of the dielectric layers while also increasing the FEXT magnitude. The dielectric of the microstrip in printed circuit boards (PCB) fabrication usually consists of two layers: …

Application Of Machine Learning In Geophysics: Ranking Teleseismic Shear Wave Splitting Measurements And Classifying Different Types Of Earthquakes, Yanwei Zhang

Doctoral Dissertations

"During the past decades, applications of Machine Learning have been explosively developed to solve various academic and industrial problems, and over-human performance has been shown in diverse areas. In geophysical research, Machine Learning, especially Convolutional Neural Network (CNN), has been applied in numerous studies and demonstrated considerable potential. In this study, we applied CNN to solve two geophysical problems, ranking teleseismic shear splitting (SWS) measurements and classifying different types of earthquakes.

For ranking teleseismic SWS measurements, we utilized a CNN-based method to automatically select reliable SWS measurements. The CNN was trained by human-verified teleseismic SWS measurements and tested using synthetic …

Optimization Of Energy Storage Scheduling In Electricity Markets, Jian Liu

Doctoral Dissertations

"In the existing literature, merchants' trading actions are usually assumed not to affect market prices; however, a large-scale energy storage merchant’s actions can affect market prices. This work examined two electricity merchant scenarios: one with only energy storage and the other with both energy storage and renewable power plants. We approximated market impact via a linear function of the electricity traded by the merchant. This study began by applying dynamic programming to the optimal economic dispatch policy of electricity merchants and it considered the market impact, physical characteristics of storage systems, and the uncertainty of renewable energy sources. Then, this …

Disorder Effects In Frustrated Magnets And Absorbing State Transitions, Xuecheng Ye

Doctoral Dissertations

"Correlation, topology, and disorder can fundamentally affect the properties of interacting many-particle systems. After a short introduction which covers the basic concepts of phase transitions and scaling as well as the physics of Josephson junctions, the dissertation focuses on three separate projects.

The first project is motivated by the stripe and nematic phases observed e.g. in cuprate superconductors and iron pnictides. To understand the effects of disorder on such phases, we have investigated the behavior of the diluted J₁-J₂ Ising model. Spinless impurities generate a random-field disorder for the spin-density (stripe) order parameter, which destroys the stripe …

Resistivity Imaging Of Prominent Seepage Pathways In Karst Terrain, Abdullah Hadi Zaid Alhaj

Doctoral Dissertations

"An integrated research approach was conducted to evaluate subsurface karstic conditions in Greene County, southwestern Missouri. Electrical resistivity tomography (ERT) was employed to image anomalously low resistivity zones associated with the presence of seepage pathways that were anthropogenic and/or natural in origin. Techniques including visual inspection (VI), multichannel analysis of surface waves (MASW), borehole control (BC), and aerial imagery (AI) were supplementally used to constrain the ERT data interpretations.

This research addressed six objectives. First, the ERT data interpretations were verified in terms of depth to the top of bedrock, fractures/voids, and moisture changes using the MASW, borehole control, and …

Mobility Analysis And Topology Synthesis Of Compliant Mechanism Using Compliance Number And Pseudo-Rigid-Body Model (Prbm), Pratheek Bagivalu Prasanna

Doctoral Dissertations

"Establishing and understanding the kinematic properties of a compliant mechanism has been a relatively recent endeavor and has proved to be a challenging task. A concept of compliance number was offered earlier; the development of terminologies was emphasized that aided in its determination. It also hypothesized that the compliance number (C) and stored strain energy, or mode shapes, are strongly correlated. This compliance number (C) concept is revisited, and a more lucid interpretation of its significance is provided. A fundamental understanding of the concept of deformation mode shapes in compliant mechanisms is formalized using two distinct categories: (i) segmental and …

Depositional Conditions, Stratigraphic Evolution, And Allo- And Autogenic Controls Of Lower Permian Non-Marine Carbonate Rocks, Lucaogou Low-Order Cycle, Bogda Mountains, Nw China, Yiran Lu

Doctoral Dissertations

"The overall objective of this study is to interpret the depositional conditions of lacustrine carbonate deposits of the lower Permian Lucaogou low-order cycle in the greater Turpan-Junggar continental rift basin, NW China. The depositional environments of ten carbonate lithofacies in the Tarlong-Taodonggou half graben and the Zhaobishan section were interpreted. Allo- and autogenic factors were identified. They controlled characteristics and distribution pattern of carbonate deposits in regional and local scale, respectively. Allogenic factors include the amount and direction of regional siliciclastic input, basin geometry, cyclic humidity/aridity oscillation, temperature, and regional tectonics. Autogenic factors include local siliciclastic input, local topography, local …

Sensitivity Of The Two-Fluid Model To Constitutive Correlations For Large Diameter Pipes, Alexander Lee Swearingen

Doctoral Dissertations

"Multiphase flows are a significant factor in nuclear reactor operations. In order to understand this behavior in reactor systems, system analysis codes are used to simulate reactor conditions. Due to the nature of the nuclear industry, simulations predicting the void development in the core are required to be highly accurate. This work evaluated the sensitivity of the void fraction and interfacial area concentration predictions to changes in correlations used to calculate three parameters that are used to complete the interfacial drag calculation. The three parameters evaluated were drift-flux, void fraction covariance, and interfacial area concentration. The change in drift-flux correlation …

Deep Learning-Based Surrogate Models For Post-Earthquake Damage Assessment, Xinzhe Yuan

Doctoral Dissertations

"Seismic damage assessment is a critical step to enhance community resilience in the wake of an earthquake. This study aims to develop deep learning-based surrogate models for widely used fragility curves to achieve more accurate and rapid assessment in practice. These surrogate models are based on artificial neural networks trained from the labelled ground motions whose resulting damage classes on targeted structures are determined by nonlinear time history analyses. The development of various surrogate models is progressed in four phases. In Phase I, the multilayer perceptron (MLP) is used to develop multivariate seismic classifiers with up to 50 hand-crafted intensity …

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The Question Is Not “Can Humans Talk?” Or “Can They Suffer?” But “Can They Reason?”, Clive Phillips

Animal Sentience

In their target article, Rowan et al (2022) make a welcome attempt to chart the development of Western progress over the past two hundred years toward formally recognizing that animals feel. They outline the heroic efforts of Compassion in World Farming to gain for animals the status of sentient beings rather than merely human property. A broader view exists, from human prehistory to the present day, in which animals have been (and still are) understood to be sentient by indigenous peoples as well as by some Eastern religions. Growing recognition in the West that animals feel represents a new age …

Adsorption Of Arsenic Onto River Sediments, Leticia Augusta Dos Santos Ferreira

Masters Theses

“Previous studies have noted the relationship between shallow groundwater rich in sodium (Na) and bicarbonate (HCO₃) and elevated levels of dissolved arsenic. However, most experimental work on arsenic adsorption in the presence of HCO₃ and differing Na/Ca ratios has proven difficult to extrapolate to natural systems because of differences in tested mineral compositions and component concentrations. In this study, I performed a series of adsorption experiments using river sediments to evaluate the influence of HCO₃ and monovalent/divalent cations on the extent of arsenic adsorption onto natural sediment in groundwater.

Batch adsorption (kinetics, equilibrium, and metal loading) …

A Variable Node Optimization Model For Byzantine Fault Tolerant Systems, Ian Robert Fulton

Masters Theses

“Byzantine Fault Tolerance (BFT) has been a major subject of study over the last two decades with increasing societal dependance on secure, correct, and reliable computer systems and online services. This research presents a model for high-level optimization of emerging systems that rely on these BFT algorithms and use a variable numbers of decision nodes. The model highlights the relationship between the security of a system and its efficiency. Two experiments were performed to determine system performance by varying the number of compromised nodes, decision nodes, and total nodes. They examine the probability that a transaction will be compromised based …

Predicting Radiated Emissions From A Cable Harness Through Component Level Tests, Fuwei Ma

Masters Theses

“In this work, a procedure is developed to predict the radiated emissions from a cable harness using component-level tests. Direct measurement on the engine control unit is utilized to accurately characterize the equivalent common mode source voltages and impedance associated with the device. The cable harness geometry is reduced using the equivalent cable bundle approach by lumping wires according to the source and load impedance compared with characteristic impedance of the harness, which dramatically reduces the measurement effort and allows practical 3D full-wave simulation of the radiated emissions. Radiated emissions are predicted from an engine control unit (ECU) and an …

Zinc Plating From Alkaline Non-Cyanide Bath, Abdul J. Mohammed

Masters Theses

“Alkaline non-cyanide zinc plating baths are preferred when trying to avoid the toxicity of cyanide baths or corrosivity of acid baths. Without additives, alkaline zincate baths produce powdery non-adherent deposits which have no use in commercial plating. Additives must be added at optimum concentrations to produce adherent, bright and uniform zinc deposits. In this study electrochemical tests were used to determine effects of additives on cathodic polarization, throwing power and morphology of deposits. Current density distribution in a unique bath of 37.5 g L^-1 Zn and 210 g L^-1 NaOH was modelled using COMSOL and validated two plating …

Characterization Of Cermet Fuel For Nuclear Thermal Propulsion (Ntp), James Floyd Mudd

Masters Theses

“A manned flight to Mars is met with many technical challenges, not the least of which is the development of propulsion technology capable of moving a transit vehicle from Earth orbit to Mars orbit. NASA is investigating Nuclear Thermal Propulsion (NTP) as a way of reducing flight time and providing the option for a mid-mission abort. NTP, which uses a high temperature nuclear reactor to heat a propellant, requires advanced fuel materials capable of withstanding temperatures well in excess of 2000 K. Among the fuel options are ceramic metal (cermet) composites composed of refractory metals and Ultra-High Temperature Ceramics (UHTCs). …

Industry 4.0 Remanufacturing: A Novel Approach Towards Smart Remanufacturing, Prashansa Ragampeta

Masters Theses

“Smart remanufacturing has become more popular in recent years as a result of its multiple benefits and the growing need for society to encourage a circular economy that leads to sustainability. One of the most common end-of-life (EoL) choices that can lead to a circular economy is remanufacturing. As a result, at the end-of-life stage of a product, it is critical to prioritize this choice over other accessible options because it is the only recovery option that retains the same quality as a new product. This work focuses on the numerous technologies that can aid in the improvement of smart …

A Convolutional Neural Network (Cnn) For Defect Detection Of Additively Manufactured Parts, Musarrat Farzana Rahman

Masters Theses

“Additive manufacturing (AM) is a layer-by-layer deposition process to fabricate parts with complex geometries. The formation of defects within AM components is a major concern for critical structural and cyclic loading applications. Understanding the mechanisms of defect formation and identifying the defects play an important role in improving the product lifecycle. The convolutional neural network (CNN) has been demonstrated to be an effective deep learning tool for automated detection of defects for both conventional and AM processes. A network with optimized parameters including proper data processing and sampling can improve the performance of the architecture. In this study, for the …

Validation Of Athlet-Cd With Cora-28 Test, Murat Tuter

Masters Theses

“Following the incidents at Chernobyl and Fukushima, severe accidents at nuclear power plants (NPP) have become a global concern. These accidents generally occur because of a failure in the reactor cooling system (RCS) and result in the melting of the reactor core and fission product release. This event is mostly caused by a LOCA, loss of flow accident, station blackout or loss of heat sink. During a severe accident, generation of hydrogen as a result of steam-zircaloy fuel cladding is a significant safety concern. To better understand and prevent the hydrogen generation issue, safety related experiments and safety related codes …