Digital Commons Network^™

Teachers' Perceptions Of Professional Development And Pedagogical Practice: A Study Of A Kentucky Suburban School District., Rachelle Bramlage-Schomburg

Electronic Theses and Dissertations

Professional development supports teacher growth and enhances pedagogical practice. Teachers in Kentucky must complete annual professional development hours and districts must develop a professional development plan tied to research that supports high-quality professional development. This qualitative case study takes place in a rural district, Bullitt County, where I investigated the teachers’ perception of a customized professional development, Thinking Focus Cohort (TFC), and its impact on their pedagogical practice. While a body of research exists on high quality professional development, there is a lack of research on the effectiveness of it, in particular a year-long cohort model with curriculum centered around …

Changing Public Perception Of Dementia: The Effect And Credibility Of Three Informational Models., Diana Hedrick

Electronic Theses and Dissertations

Background: Since the 1970s, Alzheimer’s disease and dementia have been portrayed in a medicalized, symptom-focused manner to help spread awareness, improve diagnosis, and push for treatment research. In recent decades, there has been movement towards a biopsychosocial, person-centered approach that considers social and psychological factors that interact with biological diseases processes. Common biopsychosocial approaches retain an emphasis on deficits and symptoms. New research has integrated positive psychology constructs and dementia. This integration of positive psychology principles and dementia care and research has the potential to more accurately capture the experience of having dementia. Objectives: This dissertation tested how the portrayal …

Re-Engineering Cardio-Oncology Testing Using Biomimetic Heart Slice Cultures., Jessica Miller

Electronic Theses and Dissertations

28% of drug withdrawal from the market are due to unforeseen disruptions in cardiomyocyte contractility and electrophysiology. The most commonly used platforms for drug testing are in vivo animal models and in vitro cell culture models. While both have been of paramount importance for the discovery and detection of many cardiotoxicities and mechanisms of action, they lack the ability to model an intact human myocardium. This work aims to establish cardiac tissue slices, which are 300-micron thin tissue sections taken from the left ventricular myocardium, as an alternative platform for cardio-oncology studies, specifically cardiotoxicity testing. Additionally, this work aims to …

Radiomics Of Neurodegeneration In Alzheimer's: Mr, Mrs, & Pet, Analia Basilicata, Jennifer Padilla, Anjalee Rabbani, Anam Riaz

Publications and Research

This work aims to review and assess the current state of Radiology research in Alzheimer’s Disease to complement and coordinate multi-modal research progress via Radiomics. Alzheimer’s Disease. Neuroimaging Initiative (ADNI) is a center that utilizes the different standard methods for the use of clinical magnetic resonance imaging (MRI) and positron emission tomography (PET) and cerebrospinal fluid (CSF) biomarkers for advancing. Early diagnosis and assessing the efficacy of treatment and related biomarkers for Alzheimer's’ Disease. ADNI databases can be assessed to analyze the patterns and changes in imaging and CSF biomarker data with Mild Cognitive Impairment and Alzheimer’s Disease patients. The …

Investigating Supply Parts Delivery Delay From Supply Depot To King Khaled Air Base In Royal Saudi Air Force, Rashed S. Alkhathami

Theses and Dissertations

Aircraft supply parts is an important factor in preparing the aircraft to do its mission. Due to delayed delivery of parts or inefficient delivery process, time may be lost waiting for aircraft supply parts, causing mission delay or failure. By tackling the delivery delay causes we can insure improvement on delivery process. In order to gather data for this thesis two different tools were used, aircraft parts data and an interview. Data was gathered from the F15 maintenance and supply squadrons in the Royal Saudi Air Force. Results of this research showed diverting in the main duty of supply depot …

Demarginalizing Black Ordained Women’S Voices In The Black Baptist Church: A Phenomenological Study Of Black Women Ministers’ Lived Experiences When Seeking Cleric Leadership Roles, Angela Mosley-Monts

Graduate Theses and Dissertations

This dissertation sought to understand the living experiences of Black Ordained Women in the Black Baptist Church. The study employs a phenomenological perspective and interviews to gather the voices and lived experiences of ordained Black women ministers who have served in the Black Baptist Church at various times. Womanist Theology and Black Feminism form the theoretical basis of the study. Black ordained women interviewed in this study are currently or formerly associated with the Antioch District Missionary Baptist Association, the Antioch District Congress, and the Regular Arkansas Congress of Christian Education. Although some Black ordained women remain with the Black …

Life Cycle Assessment Of Novel Electrochemical Struvite Recovery In Municipal Wastewater Treatment At The Plant And U.S. Watershed Scales, Karla Morrissey

Graduate Theses and Dissertations

As the supply of phosphorus decreases, nutrient recovery in municipal wastewater treatment has become an important area of research. Recovery methods for phosphorus-containing fertilizers, such as struvite, and other products are currently being developed and assessed for their efficiency and economic feasibility. Potential environmental impacts from nutrient recovery are also being assessed as design for the environment is important, especially with regards to the eutrophying potential of phosphorus in phosphorus-limited freshwater aquatic systems. Life cycle assessment (LCA) is a tool that can be used to estimate potential environmental impacts of a product or service focusing on its entire life cycle. …

The Value Of Early Field Experiences In Teacher Preparation, Byron Keith Mckay

Graduate Theses and Dissertations

This study examines the relationship between a preservice teacher’s early field experiences and ratings given by their cooperating teachers during student teaching. Educator preparation programs have long been tasked with providing quality education to future teachers as they prepare them for a career in the P-12 classroom. Part of this preparation happens in P-12 classroom settings, where preservice teachers observe and interact with students and professional teachers. These early field experiences, which help prepare them for student teaching and the P-12 classroom, are required for teacher preparation program accreditation. This research investigates how changes in the educational environment related to …

Exploring Leadership In An Extreme Environment: A Haiti Farm Project, Tami Strickland

Graduate Theses and Dissertations

This qualitative case study examined the impact Situational Leadership Theory II® has on followers in a small community in Haiti. Many studies have examined Situational Leadership Theory II® in corporate environments, but not in the low-income context of Haiti. The study focused on how the leadership characteristics and adaptability levels of an expatriate influenced the construction and the ongoing management of a Haiti egg farm project, which is timely based on the volatility currently in the country prior to and after the assassination of President Jovenel Moïse in 2021. Using various data gathering instruments, the study explored the expatriate’s leadership …

Student Mobility In A Choice School District And It's Impact On School Performance Scores, Trisean F. Wilson

Electronic Theses and Dissertations

Since World War II, student mobility and its relationship to student academic performance on mandated standardized tests have been researched with varied findings. Student mobility contributes to student disengagement and the postponement of instruction of mobile and nonmobile students (Smith, Fine, & Paine, 2008). Though mobility is not the sole cause of poor student performance, its indirect impact influences a school’s progress towards Adequate Yearly Progress. This quantitative study examines the correlation between student mobility and the school performance rating in an all-choice school district. State Department of Education data was used to determine school-based student mobility in the all-choice …

The Influence Of Electrical Stimulation Pulse Frequency Of Macro-Sieve Electrode On Rat Sciatic Nerve Detection Threshold, Jingyuan Zhang

McKelvey School of Engineering Graduate Student Theses & Dissertations

No abstract provided.

Computational Fluid Dynamics Modeling Of Hemodialysis In Patients With An Arteriovenous Fistula, Maximilian Roth

McKelvey School of Engineering Graduate Student Theses & Dissertations

With the advent of arteriovenous fistula (AVF) for use in hemodialysis, the anastomosis built for such use has become a central point of the study to understand the flow and wall shear stresses in such a system since very large wall shear stresses can lead to arterial/vein rupture. Considering the commonly used creation site of an anastomosis as connecting the radial artery to the cephalic vein, a model is created to calculate the wall shear stresses across various components of the system. The model depicts a connection of the specified vein and artery bridged together allowing the increase in blood …

Unlimited Central Bank Digital Currency: The Case For A Public Good In The Euro-Area And Its Regulatory (And Deregulatory) Implications For Modern Finance, Iris H-Y Chiu, Christian Hofmann

North Carolina Journal of International Law

No abstract provided.

Fallen Kingdom, Sarah E. Black

Honors College Theses

Fallen Kingdom is a novella situated in the genre of urban fantasy. Fast-paced with beautifully woven descriptions, this project aims to depict the experience of PTSD as readers follow Scarlett in her attempts to navigate lost memories, magic, and a new world. With danger lurking around every corner, her only hope is to realize her own strengths and motivations to save the person she loves most.

You Can Be Anything You Want: An Analysis Of Gender Stereotypes In Early Childhood Literature, Emily Renee Marshall

Honors College Theses

The theme of gender roles is present in many genres of literature. In early children’s literature, the vast majority of these stories portray the most common gender stereotypes, such as girls who wear pink and play with dolls, while boys wear blue and play with cars and trucks. The families’ roles are also seen in these books. For example, the mother figure is usually seen at home with the children, working in the kitchen or outside in the garden, while the father is often portrayed coming home from a long day of work in a suit and tie. These gender …

The Fan Program Plan: Creating A Healthy Church Environment For Physical Activity And Healthy Eating, John A. Bernhart Ph.D., Mph, Ches, Caroline G. Dunn, Sara Wilcox Phd, Jessica Stucker, Deborah Kinnard

Faculty Publications

Background: Faith, Activity, & Nutrition (FAN) helps churches create a healthier environment for physical activity (PA) and healthy eating (HE) through policy, systems, and environmental changes. Objective: The purpose of this paper is to describe the implementation, evaluation, and revision of the FAN Program Plan across a two-phase study to help churches create guidelines and policies for PA and HE. Methods: In Phase 1, church committees attended trainings led by Community Health Advisors (CHA) where they assessed current practices to PA and HE. Committees used the FAN Program Plan to outline an implementation plan to increase opportunities, programs, messages, pastor …

Development Of Sustainable, Efficient And Economic Manufacturing Methods For Fabricating Novel Nano-Layered Materials For Multifunctional Applications, Maharshi Dey

Theses and Dissertations

Non-oxide ternary and/or quaternary ceramics called MAX and MAB Phases have attracted a lot of interest in the recent years due to their remarkable properties like damage tolerance, and triboactive behavior as compared to their binary counterparts. These properties make these materials a strong candidate for several high temperature, hypersonic and structural applications. A wide variety of compounds including Cr2AlC and MoAlB, belonging to the same class of materials, have also been reported over the last few decades. These materials have been used as bulk materials, reinforcements and matrices for different composites and coatings on different substrates, apart from different …

Understanding Alcohol Use Discourse And Stigma Patterns In Perinatal Care On Twitter, Fritz Culp, Yuqi Wu, Dezhi Wu, Yang Ren, Phyllis Raynor Phd, Aprn, Pmhnp-Bc, Peiyin Hung Ph.D, Shan Qiao Ph.D., Xiaoming Li Ph.D., Kacey Eichelberger

Publications

(1) Background: perinatal alcohol use generates a variety of health risks. Social media platforms discuss fetal alcohol spectrum disorder (FASD) and other widespread outcomes, providing personalized user-generated content about the perceptions and behaviors related to alcohol use during pregnancy. Data collected from Twitter underscores various narrative structures and sentiments in tweets that reflect large-scale discourses and foster societal stigmas; (2) Methods: We extracted alcohol-related tweets from May 2019 to October 2021 using an official Twitter search API based on a set of keywords provided by our clinical team. Our exploratory study utilized thematic content analysis and inductive qualitative coding methods …

A New Chapter In An Evolving Pandemic: Successful Pediatric Liver Transplantation With Sars-Cov-2+ Donors, Flor M Munoz, Elizabeth Andrea Moulton, Tyler Malcolm Mccann Lambing, Sarah Koohmaraie, Nicolas Fernando Moreno, Christine A O'Mahony, John A Goss, Nhu Thao Nguyen Galván

Faculty, Staff and Students Publications

BACKGROUND: Amid a viral pandemic with poorly understood transmissibility and pathogenicity in the pediatric patient, we report the first pediatric liver transplants utilizing allografts from SARS-CoV-2+ donors.

METHODS: We describe the outcomes of two pediatric liver transplant recipients who received organs from SARS-CoV-2 nucleic acid test-positive (NAT+) donors. Data were obtained through the respective electronic medical record system and UNet DonorNet platform.

RESULTS: The first donor was a 3-year-old boy succumbing to head trauma. One of four nasopharyngeal (NP) swabs and 1 of 3 bronchoalveolar lavage (BAL) NAT tests demonstrated SARS-CoV-2 infection before organ procurement. The second donor was a …

Progress In Gastroparesis - A Narrative Review Of The Work Of The Gastroparesis Clinical Research Consortium, Thomas L Abell, Kenneth L Koch, Richard W Mccallum, Irene Sarosiek, Cheryl E Bernard, Braden Kuo, Robert Bulat, Robert J Shulman, Bruno P Chumpitazi, James Tonascia, Laura A Miriel, Laura A Wilson, Mark L Van Natta, Emily Mitchell, Frank Hamilton, Gianrico Farrugia, Henry P Parkman, Niddk/Nih Gpcrc Consortium

Faculty, Staff and Students Publications

The Gastroparesis Clinical Research Consortium is a multicenter coalition created and funded by the National Institutes of Diabetes and Digestive and Kidney Disorders, with a mission to advance understanding of the pathophysiology of gastroparesis and develop an effective treatment for patients with symptomatic gastroparesis. In this review, we summarize the results of the published Gastroparesis Clinical Research Consortium studies as a ready and convenient resource for gastroenterologists and others to provide a clear understanding of the consortium's experience and perspective on gastroparesis and related disorders.

Implementing Molecular Tuberculosis Diagnostic Methods In Limited-Resource And High-Burden Countries, Christoph Lange, Daniela Maria Cirillo

Faculty, Staff and Students Publications

Tuberculosis (TB) is one of the deadliest infectious diseases in the world with more than a million people dying of TB each year. Accurate and timely TB diagnosis has the potential to alleviate the global TB burden; therefore, one of the pillars of the End TB Strategy developed by the World Health Organization (WHO) is the early diagnosis of TB, including universal drug-susceptibility testing (DST). The WHO emphasises the importance of DST before treatment initiation, using molecular WHO-recommended rapid diagnostic tests (mWRDs). Currently available mWRDs are nucleic acid amplification tests, line probe assays, whole genome sequencing, and targeted next-generation sequencing. …

Risk Factors And Prognostic Significance Of Anemia In Children With Hiv Infection On Antiretroviral Therapy, Shaun Bulsara, Taylor Olmsted Kim, Heather Haq, Erin Peckham-Gregory, Sebastian R Wanless, Peter Elyanu, Philippa Musoke, Mwita Lumumba, Adeodata Kekitiinwa, Mogomotsi Matshaba, Jenny Despotovic, Michael Scheurer

Faculty, Staff and Students Publications

OBJECTIVES: To establish the incidence, risk factors and prognostic effect of anemia in children living with HIV (CLWH).

DESIGN: Retrospective nested case-control study of patients 0-18 years in five centers in sub-Saharan Africa, 2004-2014.

METHODS: Incident cases of anemia were identified from electronic records and matched with CLWH without anemia. We calculated the incidence density of anemia and used conditional logistic regression to evaluate its association with risk factors, stratified by severity and type of anemia. We used a Cox proportional hazards model to evaluate the impact of anemia on survival.

RESULTS: Two thousand, one hundred and thirty-seven children were …

Children And Caregiver Proxy Quality Of Life From Peanut Oral Immunotherapy Trialschildren And Caregiver Proxy Quality Of Life From Peanut Oral Immunotherapy Trials, Antonella Muraro, Carla Jones, Robert Ryan, David Norval, Jennifer Jobrack, Aikaterini Anagnostou, Julie Wang

Faculty, Staff and Students Publications

BACKGROUND: Health-related quality of life (HRQoL) is significantly and substantially reduced in individuals with peanut allergy due to many factors associated with unanticipated or potentially fatal reactions. Further insight on the impact of peanut oral immunotherapy in managing peanut allergy on HRQoL is needed. The aim of this analysis was to assess effects of peanut (Arachis hypogaea) allergen powder-dnfp (PTAH), a biologic drug for peanut oral immunotherapy, on HRQoL from three phase 3 and two follow-on trials of PTAH.

METHODS: HRQoL assessments from participants aged 4-17 in the PALISADE (ARC003), ARC004 (PALISADE follow-on), ARTEMIS (ARC010), RAMSES (ARC007), and ARC011 (RAMSES …

Foxi3 Haploinsufficiency Contributes To Low T-Cell Receptor Excision Circles And T-Cell Lymphopenia, Morgan Similuk, Ottavia M Delmonte, Francesca Pala, Christine Peng, Colleen Jodarski, Michael D Keller, Ivan K Chinn, Andrew K Groves, Luigi D Notarangelo, Magdalena A Walkiewicz, Javier Chinen, Vanessa Bundy

Faculty, Staff and Students Publications

BACKGROUND: Newborn screening can identify neonatal T-cell lymphopenia through detection of a low number of copies of T-cell receptor excision circles in dried blood spots collected at birth. After a positive screening result, further diagnostic testing is required to determine whether the subject has severe combined immunodeficiency or other causes of T-cell lymphopenia. Even after thorough evaluation, approximately 15% of children with a positive result of newborn screening for T-cell receptor excision circles remain genetically undiagnosed. Identifying the underlying genetic etiology is necessary to guide subsequent clinical management and family planning.

OBJECTIVE: We sought to elucidate the genetic basis of …

Assessment For Deeper Understanding Using Concept Maps: Lessons Learned From Flipped Teaching Of Pharmacology

Faculty, Staff and Students Publications

To foster a deeper understanding of pharmacology concepts among physician assistant students, we integrated concept mapping into our flipped teaching to provide assessment for learning. Different mapping-based assessment strategies were adopted based on learner feedback, including in-person collaborative mapping, an individual computerized mapping-based quiz with automated feedback, and a collaborative computerized mapping-based quiz enhanced by the jigsaw strategy. Each mapping activity also leveraged the strength of a specific technology platform. Based on the findings from comparing learner ratings of these mapping activities and thematic analysis of learner feedback, we engaged in critical reflection and share our lessons learned.

A Consensus List Of Ultrasound Competencies For Graduating Emergency Medicine Residents, Jennifer Carnell, Jason T Nomura, John Bailitz, Jeremy S Boyd, Megan M Leo, E Liang Liu, Youyou Duanmu, Josie Acuña, Ross Kessler, Marco F Elegante, Mathew Nelson, Rachel B Liu, Resa E Lewiss, Arun Nagdev, Rob D Huang

Faculty, Staff and Students Publications

OBJECTIVES: Emergency ultrasound (EUS) is a critical component of emergency medicine (EM) resident education. Currently, there is no consensus list of competencies for EUS training, and graduating residents have varying levels of skill and comfort. The objective of this study was to define a widely accepted comprehensive list of EUS competencies for graduating EM residents through a modified Delphi method.

METHODS: We developed a list of EUS applications through a comprehensive literature search, the American College of Emergency Physicians list of core EUS benchmarks, and the Council of Emergency Medicine Residency-Academy of Emergency Ultrasound consensus document. We assembled a multi-institutional …

Proteasome Inhibitors Silence Oncogenes In Multiple Myeloma Through Localized Histone Deacetylase 3 (Hdac3) Stabilization And Chromatin Condensation, Joanne I Hsu, Ragini M Mistry, Fabio Stossi, Premal Lulla, Zheng Sun, Ergun Sahin, Sarvari V Yellapragada, André Catic

Faculty, Staff and Students Publications

Proteasome inhibitors have become the standard of care for multiple myeloma (MM). Blocking protein degradation particularly perturbs the homeostasis of short-lived polypeptides such as transcription factors and epigenetic regulators. To determine how proteasome inhibitors directly impact gene regulation, we performed an integrative genomics study in MM cells. We discovered that proteasome inhibitors reduce the turnover of DNA-associated proteins and repress genes necessary for proliferation through epigenetic silencing. Specifically, proteasome inhibition results in the localized accumulation of histone deacetylase 3 (HDAC3) at defined genomic sites, which reduces H3K27 acetylation and increases chromatin condensation. The loss of active chromatin at super-enhancers critical …

A Phase I/Ii Trial Of Nivolumab Plus Ipilimumab In Children And Young Adults With Relapsed/Refractory Solid Tumors: A Children's Oncology Group Study Advl1412, Joel M Reid, Xiaowei Liu, Charles G Minard, Stephan Voss, Stacey L Berg, Brenda J Weigel, Crystal L Mackall

Faculty, Staff and Students Publications

PURPOSE: In many cancers, nivolumab in combination with ipilimumab improves response rates compared with either agent alone, but the combination has not been evaluated in childhood cancer. We conducted a phase I/II trial of nivolumab plus ipilimumab in children and young adults with recurrent/refractory solid tumors.

PATIENTS AND METHODS: ADVL1412, Part C assessed safety of nivolumab plus ipilimumab at two dose levels (DL): DL1 1 mg/kg of each drug and DL2 3 mg/kg nivolumab plus 1 mg/kg ipilimumab. Part D evaluated response at the recommended phase II dose (RP2D) in Ewing sarcoma, rhabdomyosarcoma, and osteosarcoma. Part E tested DL3 (1 …

Comparative Effectiveness Of Surveillance Colonoscopy Intervals On Colorectal Cancer Outcomes In A National Cohort Of Patients With Inflammatory Bowel Disease, Akbar K Waljee, Frank I Scott, James D Lewis, Hashem B El-Serag, Jason K Hou

Faculty, Staff and Students Publications

BACKGROUND & AIMS: Surveillance colonoscopy is recommended to reduce colorectal cancer (CRC)-related morbidity and mortality in patients with inflammatory bowel disease (IBD). The comparative effectiveness of varying colonoscopy intervals on CRC outcomes among patients with IBD is unknown.

METHODS: We performed a retrospective cohort study of patients with confirmed CRC within a cohort of 77,824 patients with IBD during 2000 to 2015 in the National Veterans Health Administration. We examined the association between colonoscopy surveillance intervals on CRC stage, treatment, or all-cause and cancer-specific mortality. The interval of colonoscopy prior to CRC diagnosis was categorized as those performed within <1 >year, …

Simultaneous Use Of Endobronchial And Endoscopic Ultrasound Guidance As Primary Tools In The Diagnosis Of Malignant Pleural Mesothelioma, Quillann Huang, Munish Sharma

Faculty, Staff and Students Publications

Malignant pleural mesothelioma (MPM) is related to exposure to asbestos. It is insidious in nature and is generally diagnosed at an advanced stage. MPM is aggressive and portends a poor prognosis. Definitive diagnosis is usually established by obtaining pathological samples of the pleura by medical or surgical thoracoscopy. However, these procedures are invasive and carry a risk of seeding of biopsy sites with tumors. We herein report an infrequently encountered case of simultaneous use of endobronchial ultrasound and endoscopic ultrasound-guided biopsy of malignant pleural mesothelioma in a 48-year-old female patient.