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2022

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Factors Predicting Family And Consumer Sciences Teachers' Levels Of Self-Efficacy In Stem Education, Charlene Wirfel Smith Dec 2022

Factors Predicting Family And Consumer Sciences Teachers' Levels Of Self-Efficacy In Stem Education, Charlene Wirfel Smith

STEMPS Theses & Dissertations

Education in science, technology, engineering, and mathematics (STEM) has become widely promoted in recent years. Quality STEM education could maintain or increase the number of individuals preparing for careers in these fields and increase STEM literacy for the population. Family and Consumer Sciences (FCS) education has always used science to improve home life while reinforcing technology, engineering, and mathematics principles through hands on, relevant learning activities in the classroom. However, it is not usually recognized as a STEM subject. The purpose of this study was to determine what factors may affect FCS teachers’ level of self-efficacy in teaching STEM education …


Case Study Of A District-University Partnership: Developing Culturally Responsive Educators In A Rural Setting, Trenice Shauntel Durio Dec 2022

Case Study Of A District-University Partnership: Developing Culturally Responsive Educators In A Rural Setting, Trenice Shauntel Durio

Educational Leadership & Workforce Development Theses & Dissertations

Using a theoretical framework of critical race theory and conceptual frameworks of cultural education, this study explores the intersection of district-university partnerships and culturally responsive education. The purpose of this mixed methods case study was to examine the formulation and outcomes of a district-university partnership established to offer a college level course focused on anti-discrimination, equity and inclusion, and social justice in schools. Using survey data, I explored the relationship between participation in the course and the participants’ self-reflection in the areas of empathic concern and perspective taking, preparation for culturally responsive teaching and equitable practices, and comfortability with discussions …


Family Writer's Workshop: A Case Study, Alisa Innes Dec 2022

Family Writer's Workshop: A Case Study, Alisa Innes

Teaching & Learning Theses & Dissertations

Today’s students need to be prepared for a successful future in our competitive world. Families and educators need to work together to provide children with a comprehensive literacy foundation. Currently, there are many school-based and community-based family literacy programs that are being implemented. While these programs are successful, they are missing a crucial component: writing intervention. Writing is a skill that our students will need for higher education and future careers.

The problem for this study was that research is lacking in regards to ways to assist parents who are interested in working on writing with their child outside of …


An Acute Sense Of Place: The Songs Of Norman Blake, Thomas Jutz Dec 2022

An Acute Sense Of Place: The Songs Of Norman Blake, Thomas Jutz

Electronic Theses and Dissertations

American flat-picking guitarist, singer and songwriter Norman Blake holds legendary status among guitar players, bluegrass, and folk musicians.

The aim of this research is to analyze the interaction of sense of place in Norman Blake’s songwriting. This research will explore the techniques Blake uses to create that acute sense of place. Elements of literary criticism, cultural geography, ethnomusicology, and sense of place studies, as well as historical background information on Northern Alabama and North Georgia will be employed to show how this particular region of Southeastern Appalachia has informed Blake’s songwriting.

The research questions that I aim to answer are …


Opinion Mining Of Bird Preference In Wildlife Parks, Isiwat Adenopo Dec 2022

Opinion Mining Of Bird Preference In Wildlife Parks, Isiwat Adenopo

Electronic Theses and Dissertations

Opinion Mining is becoming the fastest growing area to extract useful and insightful information to support decision making. In the age of social media, user’s opinions and discussions have become a highly valuable source to look for users preferences, likes, and dislikes.

The industry of wildlife parks (or zoos) is a competitive domain that requires careful analysis of visitor’s opinions to understand and cater for their preferences when it comes to wildlife. In this thesis, an opinion mining approach was proposed and applied on textual posts on the social media platform, Twitter, to extract the popularity, polarity (sentiment), and emotions …


“It’S About The Two Selves”: Experiences In Code-Switching Between Home And Academic Environments, Travis Wolven Dec 2022

“It’S About The Two Selves”: Experiences In Code-Switching Between Home And Academic Environments, Travis Wolven

Electronic Theses and Dissertations

This qualitative research study is an exploration of how college students navigate code-switching between their home and academic environments. Data were collected from five participants using interview and small group methods. Through the lenses of Coordinated Management of Meaning (CMM) and Memorable Messages (MM) frameworks, the researcher explores how key MMs affect how participants coordinate and manage meaning in communications with others in their home and college environments. Findings were fourfold: 1) participants chose between following established and creating new rules when code-switching; 2) participants shared experiences and strategies regarding knowing when and how to code-switch; 3) preparing audiences for …


Design Of The Remedē System Therapy (Rēst) Study: A Prospective Non-Randomized Post-Market Study Collecting Clinical Data On Safety And Effectiveness Of The Remedē System For The Treatment Of Central Sleep Apnea, Lee R Goldberg, Henrik Fox, Christoph Stellbrink, Biykem Bozkurt, John P Boehmer, Jorge I Mora, Rahul Doshi, Timothy I Morgenthaler, Wayne C Levy, Timothy E Meyer, Scott W Mckane, Robin Germany, Remedē System Therapy Study Group Dec 2022

Design Of The Remedē System Therapy (Rēst) Study: A Prospective Non-Randomized Post-Market Study Collecting Clinical Data On Safety And Effectiveness Of The Remedē System For The Treatment Of Central Sleep Apnea, Lee R Goldberg, Henrik Fox, Christoph Stellbrink, Biykem Bozkurt, John P Boehmer, Jorge I Mora, Rahul Doshi, Timothy I Morgenthaler, Wayne C Levy, Timothy E Meyer, Scott W Mckane, Robin Germany, Remedē System Therapy Study Group

Faculty, Staff and Students Publications

Background: Central sleep apnea (CSA) is a disorder defined by lack of respiratory drive from the brain stem on breathing efforts. There is a lack of established therapies for CSA and most available therapies are limited by poor patient adherence, limited randomized controlled studies, and potentially adverse cardiovascular effects. The remedē System (ZOLL Respicardia, Inc., Minnetonka, Minnesota) uses transvenous phrenic nerve stimulation to stimulate the diaphragm, thereby restoring a more normal breathing pattern throughout the sleep period.

Methods: The remedē System Therapy (rēST) Study is a prospective non-randomized multicenter international study evaluating long-term safety and effectiveness of the remedē System …


Long Read Sequencing And Expression Studies Of Ahdc1 Deletions In Xia-Gibbs Syndrome Reveal A Novel Genetic Regulatory Mechanism, Varuna Chander, Medhat Mahmoud, Jianhong Hu, Zain Dardas, Christopher M Grochowski, Moez Dawood, Michael M Khayat, He Li, Shoudong Li, Shalini Jhangiani, Viktoriya Korchina, Hua Shen, George Weissenberger, Qingchang Meng, Marie-Claude Gingras, Donna M Muzny, Harsha Doddapaneni, Jennifer E Posey, James R Lupski, Aniko Sabo, David R Murdock, Fritz J Sedlazeck, Richard A Gibbs Dec 2022

Long Read Sequencing And Expression Studies Of Ahdc1 Deletions In Xia-Gibbs Syndrome Reveal A Novel Genetic Regulatory Mechanism, Varuna Chander, Medhat Mahmoud, Jianhong Hu, Zain Dardas, Christopher M Grochowski, Moez Dawood, Michael M Khayat, He Li, Shoudong Li, Shalini Jhangiani, Viktoriya Korchina, Hua Shen, George Weissenberger, Qingchang Meng, Marie-Claude Gingras, Donna M Muzny, Harsha Doddapaneni, Jennifer E Posey, James R Lupski, Aniko Sabo, David R Murdock, Fritz J Sedlazeck, Richard A Gibbs

Faculty, Staff and Students Publications

Xia-Gibbs syndrome (XGS; MIM# 615829) is a rare mendelian disorder characterized by Development Delay (DD), intellectual disability (ID), and hypotonia. Individuals with XGS typically harbor de novo protein-truncating mutations in the AT-Hook DNA binding motif containing 1 (AHDC1) gene, although some missense mutations can also cause XGS. Large de novo heterozygous deletions that encompass the AHDC1 gene have also been ascribed as diagnostic for the disorder, without substantial evidence to support their pathogenicity. We analyzed 19 individuals with large contiguous deletions involving AHDC1, along with other genes. One individual bore the smallest known contiguous AHDC1 deletion (∼350 Kb), encompassing eight …


A Toddler With New Seizures, Progressive White Matter Lesions, And Multifocal Microhemorrhages, Dana Tlais, Stephanie Fetzko, Nitya Gulati, Huy Brandon D Tran, Sarah Risen, Yi-Chen Lai Dec 2022

A Toddler With New Seizures, Progressive White Matter Lesions, And Multifocal Microhemorrhages, Dana Tlais, Stephanie Fetzko, Nitya Gulati, Huy Brandon D Tran, Sarah Risen, Yi-Chen Lai

Faculty, Staff and Students Publications

A 16-month-old, previously healthy male is hospitalized for new onset seizures. Initial investigation is significant for enterovirus/rhinovirus respiratory infection, abnormal T2 signal predominantly in the white matter and scattered microhemorrhages on brain MRI, transaminitis, and thrombocytopenia. His symptoms initially improve on steroid therapy and he is discharged from the hospital. During the ensuing month with the tapering of the steroids, he develops new motor deficits for which he is rehospitalized. His laboratory investigation on readmission is unremarkable. However, there is significant progression of white matter lesions and microhemorrhages on repeat MRI. While in the hospital, he becomes febrile and has …


“Immigration Enforcement Is A Daily Part Of Our Students’ Lives”: School Social Workers’ Perceptions Of Racialized Nested Contexts Of Reception For Immigrant Students, Sophia Rodriguez, Benjamin J. Roth, Leticia Villarreal Sosa Dec 2022

“Immigration Enforcement Is A Daily Part Of Our Students’ Lives”: School Social Workers’ Perceptions Of Racialized Nested Contexts Of Reception For Immigrant Students, Sophia Rodriguez, Benjamin J. Roth, Leticia Villarreal Sosa

School of Social Work Faculty Publications

This qualitative analysis examines school social workers’ equity work for immigrant students, including their perceptions of immigration enforcement and school climates that support or hinder immigrant student experiences. We conceptually expand understandings of nested contexts of reception and racialized organizations across macro, meso, micro levels, and how they affect immigrant students’ educational experiences, mobility, and belonging. Utilizing open-ended responses from a unique national survey data set, we examine school social workers’ perceptions of the macro, meso, micro racialized contexts that immigrant students encounter, how school social worker perceptions reflect racial attitudes as part of the racialized organization of schools in …


A Preliminary Exploration On The Views Of Terrorism Among Indian And U.S. College Students, Eric G. Lambert, Shanhe Jiang, N. Prabha Unnithan, Sudershan Pasupuleti Dec 2022

A Preliminary Exploration On The Views Of Terrorism Among Indian And U.S. College Students, Eric G. Lambert, Shanhe Jiang, N. Prabha Unnithan, Sudershan Pasupuleti

School of Social Work Faculty Publications

No corner of the world is completely safe from terrorist attacks. Both India and the United States have suffered horrific acts of terrorist-inspired violence. While views of terrorism vary for different reasons, culture certainly plays a role. A total of 918 undergraduate college students, composed of 434 Indian students and 484 U.S. students, were surveyed on their views of terrorism, responses to terrorism, and appropriate punishment of terrorists. Ordered ordinal regression results indicated a significant difference on 20 of the 26 items by nationality. Indian participants were more likely to express strong views on the problem of terrorism for society …


Understanding Post-Covid-19 Interstitial Lung Disease (Ild): A New Fibroinflammatory Disease Entity, Puja Mehta, Ivan O Rosas, Mervyn Singer Dec 2022

Understanding Post-Covid-19 Interstitial Lung Disease (Ild): A New Fibroinflammatory Disease Entity, Puja Mehta, Ivan O Rosas, Mervyn Singer

Faculty, Staff and Students Publications

Immunomodulation and immunity from vaccination and natural infection have reduced mortality from coronavirus disease 2019 (COVID-19). However, there are ongoing concerns regarding emerging variants and residual pulmonary sequelae in survivors, given that the lungs are the principal site for the triumvirate of infection, inflammation and injury. The initial waves of acute, severe COVID-19 were profoundly inflammatory, usually manifest as organising pneumonia ± acute respiratory distress syndrome (ARDS). The extent of the fibrogenic potential of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and the modifiability of the pathogenic processes and disease course are unclear. Interestingly patients can develop ‘post-COVID interstitial lung disease’ …


Growth Parameters In Children With Achondroplasia: A 7-Year, Prospective, Multinational, Observational Study, Ravi Savarirayan, Melita Irving, Paul Harmatz, Borja Delgado, William R Wilcox, John Philips, Natalie Owen, Carlos A Bacino, Louise Tofts, Joel Charrow, Lynda E Polgreen, Julie Hoover-Fong, Paul Arundel, Ignacio Ginebreda, Howard M Saal, Donald Basel, Rosendo Ullot Font, Keiichi Ozono, Michael B Bober, Valerie Cormier-Daire, Kim-Hanh Le Quan Sang, Genevieve Baujat, Yasemin Alanay, Frank Rutsch, Daniel Hoernschemeyer, Klaus Mohnike, Hiroshi Mochizuki, Asako Tajima, Yumiko Kotani, David D Weaver, Klane K White, Clare Army, Kevin Larrimore, Keith Gregg, George Jeha, Claire Milligan, Elena Fisheleva, Alice Huntsman-Labed, Jonathan Day Dec 2022

Growth Parameters In Children With Achondroplasia: A 7-Year, Prospective, Multinational, Observational Study, Ravi Savarirayan, Melita Irving, Paul Harmatz, Borja Delgado, William R Wilcox, John Philips, Natalie Owen, Carlos A Bacino, Louise Tofts, Joel Charrow, Lynda E Polgreen, Julie Hoover-Fong, Paul Arundel, Ignacio Ginebreda, Howard M Saal, Donald Basel, Rosendo Ullot Font, Keiichi Ozono, Michael B Bober, Valerie Cormier-Daire, Kim-Hanh Le Quan Sang, Genevieve Baujat, Yasemin Alanay, Frank Rutsch, Daniel Hoernschemeyer, Klaus Mohnike, Hiroshi Mochizuki, Asako Tajima, Yumiko Kotani, David D Weaver, Klane K White, Clare Army, Kevin Larrimore, Keith Gregg, George Jeha, Claire Milligan, Elena Fisheleva, Alice Huntsman-Labed, Jonathan Day

Faculty, Staff and Students Publications

Purpose: This study was undertaken to collect baseline growth parameters in children with achondroplasia who might enroll in interventional trials of vosoritide, and to establish a historical control.

Methods: In this prospective, observational study, participants (≤17 years) underwent a detailed medical history and physical examination and were followed every 3 months until they finished participating in the study by enrolling in an interventional trial or withdrawing.

Results: A total of 363 children were enrolled (28 centers, 8 countries). Mean (SD) follow up was 20.4 (15.0) months. In participants < 1 year, mean annualized growth velocity (AGV) was 11.6 cm/year for girls and 14.6 cm/year for boys. By age 1 year, mean AGV decreased to 7.4 cm/year in girls and 7.1 cm/year in boys. By age 10 years, mean AGV decreased to 3.6 cm/year for both sexes. Mean height z-score in participants < 1 year was -2.5 for girls and -3.2 for boys and decreased up to the age 5 years (-5.3 for girls; -4.6 for boys). Girls and boys had a disproportionate upper-to-lower body segment ratio. Mean ratio was highest in participants aged < 1 year (2.9 for girls; 2.8 for boys) and decreased gradually to approximately 2 in both sexes from 4 years of age onward.

Conclusion: This study represents one of the largest datasets of prospectively collected …


Exome Sequencing Efficacy And Phenotypic Expansions Involving Esophageal Atresia/Tracheoesophageal Fistula Plus, Mary R Sy, Jaynee Chauhan, Katrina Prescott, Aliza Imam, Alison Kraus, Ana Beleza, Lee Salkeld, Saraswati Hosdurga, Michael Parker, Pradeep Vasudevan, Lily Islam, Himanshu Goel, Nicole Bain, Soo-Mi Park, Shehla Mohammed, Klaus Dieterich, Charles Coutton, Véronique Satre, Gaëlle Vieville, Alan Donaldson, Claire Beneteau, Jamal Ghoumid, Kris Van Den Bogaert, Anneleen Boogaerts, Elise Boudry, Clémence Vanlerberghe, Florence Petit, Laura Bernardini, Barbara Torres, Teresa Mattina, Diana Carli, Giorgia Mandrile, Michele Pinelli, Nicola Brunetti-Pierri, Katherine Neas, Rachel Beddow, Pernille M Tørring, Flavio Faletra, Beatrice Spedicati, Paolo Gasparini, Alessandro Mussa, Giovanni Battista Ferrero, Anne Lampe, Wayne Lam, Weimin Bi, Carlos A Bacino, Akela Kuwahara, Jeffrey O Bush, Xiaonan Zhao, Pamela N Luna, Chad A Shaw, Jill A Rosenfeld, Daryl A Scott Dec 2022

Exome Sequencing Efficacy And Phenotypic Expansions Involving Esophageal Atresia/Tracheoesophageal Fistula Plus, Mary R Sy, Jaynee Chauhan, Katrina Prescott, Aliza Imam, Alison Kraus, Ana Beleza, Lee Salkeld, Saraswati Hosdurga, Michael Parker, Pradeep Vasudevan, Lily Islam, Himanshu Goel, Nicole Bain, Soo-Mi Park, Shehla Mohammed, Klaus Dieterich, Charles Coutton, Véronique Satre, Gaëlle Vieville, Alan Donaldson, Claire Beneteau, Jamal Ghoumid, Kris Van Den Bogaert, Anneleen Boogaerts, Elise Boudry, Clémence Vanlerberghe, Florence Petit, Laura Bernardini, Barbara Torres, Teresa Mattina, Diana Carli, Giorgia Mandrile, Michele Pinelli, Nicola Brunetti-Pierri, Katherine Neas, Rachel Beddow, Pernille M Tørring, Flavio Faletra, Beatrice Spedicati, Paolo Gasparini, Alessandro Mussa, Giovanni Battista Ferrero, Anne Lampe, Wayne Lam, Weimin Bi, Carlos A Bacino, Akela Kuwahara, Jeffrey O Bush, Xiaonan Zhao, Pamela N Luna, Chad A Shaw, Jill A Rosenfeld, Daryl A Scott

Faculty, Staff and Students Publications

Esophageal atresia/tracheoesophageal fistula (EA/TEF) is a life-threatening birth defect that often occurs with other major birth defects (EA/TEF+). Despite advances in genetic testing, a molecular diagnosis can only be made in a minority of EA/TEF+ cases. Here, we analyzed clinical exome sequencing data and data from the DECIPHER database to determine the efficacy of exome sequencing in cases of EA/TEF+ and to identify phenotypic expansions involving EA/TEF. Among 67 individuals with EA/TEF+ referred for clinical exome sequencing, a definitive or probable diagnosis was made in 11 cases for an efficacy rate of 16% (11/67). This efficacy rate is significantly lower …


Supporting Inclusive Learning Using Chatbots? A Chatbot-Led Interview Study, Sambhav Gupta, Yu Chen Dec 2022

Supporting Inclusive Learning Using Chatbots? A Chatbot-Led Interview Study, Sambhav Gupta, Yu Chen

Faculty Research, Scholarly, and Creative Activity

Supporting student academic success has been one of the major goals for higher education. However, low teacher-to-student ratio makes it difficult for students to receive sufficient and personalized support that they might want to. The advancement of artificial intelligence (AI) and conversational agents, such as chatbots, has provided opportunities for assisting learning for different types of students. This research aims at investigating the opportunities and requirements of chatbots as an intelligent helper to facilitate equity in learning. We developed a chatbot as an experimental platform to investigate the design opportunities of using chatbots to support inclusive learning. Through a chatbot-led …


Statin Use And Risk Of Diabetes By Subclinical Atherosclerosis Burden (From A Multi-Ethnic Study Of Atherosclerosis Report), Mahmoud Al Rifai, Moyses Szklo, Jaideep Patel, Michael J Blaha, Christie M Ballantyne, Vera Bittner, Pamela Morris, John W Mcevoy, Michael D Shapiro, Mouaz H Al-Mallah, Philip Greenland, Salim S Virani Dec 2022

Statin Use And Risk Of Diabetes By Subclinical Atherosclerosis Burden (From A Multi-Ethnic Study Of Atherosclerosis Report), Mahmoud Al Rifai, Moyses Szklo, Jaideep Patel, Michael J Blaha, Christie M Ballantyne, Vera Bittner, Pamela Morris, John W Mcevoy, Michael D Shapiro, Mouaz H Al-Mallah, Philip Greenland, Salim S Virani

Faculty, Staff and Students Publications

Although there is a significant reduction in atherosclerotic cardiovascular disease risk with statins, a higher risk of diabetes mellitus has been demonstrated in randomized clinical trials. The risk of incident diabetes with statins may be heterogeneous by presence of coronary artery calcium (CAC). We evaluated participants without prevalent diabetes at baseline from the MESA (Multi-Ethnic Study of Atherosclerosis), a prospective cohort study of subjects free of clinical cardiovascular disease at baseline. We used multivariable-adjusted Cox proportional hazards models to study the association between statin use and incident diabetes, adjusting for sociodemographic and cardiovascular risk factors, including time-varying statin use and …


Association Between Cause Of Kidney Failure And Fracture Incidence In A National Us Dialysis Population Cohort Study, Susan Ziolkowski, Sai Liu, Maria E Montez-Rath, Michelle Denburg, Wolfgang C Winkelmayer, Glenn M Chertow, Michelle M O'Shaughnessy Dec 2022

Association Between Cause Of Kidney Failure And Fracture Incidence In A National Us Dialysis Population Cohort Study, Susan Ziolkowski, Sai Liu, Maria E Montez-Rath, Michelle Denburg, Wolfgang C Winkelmayer, Glenn M Chertow, Michelle M O'Shaughnessy

Faculty, Staff and Students Publications

Background: Whether fracture rates, overall and by fracture site, vary by cause of kidney failure in patients receiving dialysis is unknown.

Methods: Using the US Renal Data System, we compared fracture rates across seven causes of kidney failure in patients who started dialysis between 1997 and 2014. We computed unadjusted and multivariable adjusted proportional sub-distribution hazard models, with fracture events (overall, and by site) as the outcome and immunoglobulin A nephropathy as the reference group. Kidney transplantation and death were competing events.

Results: Among 491 496 individuals, with a median follow-up of 2.0 (25%, 75% range 0.9-3.9) years, 62 954 …


Implementation Of Systematic Safety Checklists In A Neurocritical Care Unit: A Quality Improvement Study, César E Escamilla-Ocañas, Gabriel Torrealba-Acosta, Pitchaiah Mandava, Muhammad Suhaib Qasim, Bárbara Gutiérrez-Flores, Eric Bershad, Mohammad Hirzallah, Chethan P Venkatasubba Rao, Rahul Damani Dec 2022

Implementation Of Systematic Safety Checklists In A Neurocritical Care Unit: A Quality Improvement Study, César E Escamilla-Ocañas, Gabriel Torrealba-Acosta, Pitchaiah Mandava, Muhammad Suhaib Qasim, Bárbara Gutiérrez-Flores, Eric Bershad, Mohammad Hirzallah, Chethan P Venkatasubba Rao, Rahul Damani

Faculty, Staff and Students Publications

Background and objectives: Structured and systematised checklists have been shown to prevent complications and improve patient care. We evaluated the implementation of systematic safety checklists in our neurocritical care unit (NCCU) and assessed its effect on patient outcomes.

Design/methods: This quality improvement project followed a Plan-Do-Study-Act (PDSA) methodology. A checklist for medication reconciliation, thromboembolic prophylaxis, glycaemic control, daily spontaneous awakening, breathing trial, diet, catheter/lines duration monitoring and antibiotics de-escalation was implemented during daily patient rounds. Main outcomes included the rate of new infections, mortality and NCCU-length of stay (LOS). Intervened patients were compared with historical controls after propensity score and …


K27m In Canonical And Noncanonical H3 Variants Occurs In Distinct Oligodendroglial Cell Lineages In Brain Midline Gliomas, Selin Jessa, Abdulshakour Mohammadnia, Ashot S Harutyunyan, Maud Hulswit, Srinidhi Varadharajan, Hussein Lakkis, Nisha Kabir, Zahedeh Bashardanesh, Steven Hébert, Damien Faury, Maria C Vladoiu, Samantha Worme, Marie Coutelier, Brian Krug, Augusto Faria Andrade, Manav Pathania, Andrea Bajic, Alexander G Weil, Benjamin Ellezam, Jeffrey Atkinson, Roy W R Dudley, Jean-Pierre Farmer, Sebastien Perreault, Benjamin A Garcia, Valérie Larouche, Mathieu Blanchette, Livia Garzia, Aparna Bhaduri, Keith L Ligon, Pratiti Bandopadhayay, Michael D Taylor, Stephen C Mack, Nada Jabado, Claudia L Kleinman Dec 2022

K27m In Canonical And Noncanonical H3 Variants Occurs In Distinct Oligodendroglial Cell Lineages In Brain Midline Gliomas, Selin Jessa, Abdulshakour Mohammadnia, Ashot S Harutyunyan, Maud Hulswit, Srinidhi Varadharajan, Hussein Lakkis, Nisha Kabir, Zahedeh Bashardanesh, Steven Hébert, Damien Faury, Maria C Vladoiu, Samantha Worme, Marie Coutelier, Brian Krug, Augusto Faria Andrade, Manav Pathania, Andrea Bajic, Alexander G Weil, Benjamin Ellezam, Jeffrey Atkinson, Roy W R Dudley, Jean-Pierre Farmer, Sebastien Perreault, Benjamin A Garcia, Valérie Larouche, Mathieu Blanchette, Livia Garzia, Aparna Bhaduri, Keith L Ligon, Pratiti Bandopadhayay, Michael D Taylor, Stephen C Mack, Nada Jabado, Claudia L Kleinman

Faculty, Staff and Students Publications

Canonical (H3.1/H3.2) and noncanonical (H3.3) histone 3 K27M-mutant gliomas have unique spatiotemporal distributions, partner alterations and molecular profiles. The contribution of the cell of origin to these differences has been challenging to uncouple from the oncogenic reprogramming induced by the mutation. Here, we perform an integrated analysis of 116 tumors, including single-cell transcriptome and chromatin accessibility, 3D chromatin architecture and epigenomic profiles, and show that K27M-mutant gliomas faithfully maintain chromatin configuration at developmental genes consistent with anatomically distinct oligodendrocyte precursor cells (OPCs). H3.3K27M thalamic gliomas map to prosomere 2-derived lineages. In turn, H3.1K27M ACVR1-mutant pontine gliomas uniformly mirror early ventral …


Proteasome Inhibitors Silence Oncogenes In Multiple Myeloma Through Localized Histone Deacetylase 3 (Hdac3) Stabilization And Chromatin Condensation, Laure Maneix, Polina Iakova, Shannon E Moree, Joanne I Hsu, Ragini M Mistry, Fabio Stossi, Premal Lulla, Zheng Sun, Ergun Sahin, Sarvari V Yellapragada, André Catic Dec 2022

Proteasome Inhibitors Silence Oncogenes In Multiple Myeloma Through Localized Histone Deacetylase 3 (Hdac3) Stabilization And Chromatin Condensation, Laure Maneix, Polina Iakova, Shannon E Moree, Joanne I Hsu, Ragini M Mistry, Fabio Stossi, Premal Lulla, Zheng Sun, Ergun Sahin, Sarvari V Yellapragada, André Catic

Faculty, Staff and Students Publications

Proteasome inhibitors have become the standard of care for multiple myeloma (MM). Blocking protein degradation particularly perturbs the homeostasis of short-lived polypeptides such as transcription factors and epigenetic regulators. To determine how proteasome inhibitors directly impact gene regulation, we performed an integrative genomics study in MM cells. We discovered that proteasome inhibitors reduce the turnover of DNA-associated proteins and repress genes necessary for proliferation through epigenetic silencing. Specifically, proteasome inhibition results in the localized accumulation of histone deacetylase 3 (HDAC3) at defined genomic sites, which reduces H3K27 acetylation and increases chromatin condensation. The loss of active chromatin at super-enhancers critical …


Improving Parental Education, Daisy Martinez Ortiz Dec 2022

Improving Parental Education, Daisy Martinez Ortiz

Capstone Projects and Master's Theses

Monterey County has one of the highest records of child maltreatment that leads to life-long consequences. COVID-19 has significantly impacted the way parent education classes are being delivered. Without the proper parental education, child maltreatment increases. Parental stress has also greatly contributed. All the stress brought among parents also posed as a factor for increased violence and child abuse. Low levels of parental education results in poor parenting. Poor parenting greatly affects a child’s social, emotional, and intellectual development. Community Human Services is a nonprofit organization dedicated to addressing a variety of issues. Among their different departments, under their mental …


A Dialogical Approach To Peer Coaching For Asset Pedagogies, Elisabeth Van Beek Dec 2022

A Dialogical Approach To Peer Coaching For Asset Pedagogies, Elisabeth Van Beek

Dissertations

The purpose of this study was to understand how dialogical peer coaching using an asset pedagogical framework supported the development of culturally sustaining pedagogy (Gay, 2000; Ladson-Billings, 1994; Paris & Alim, 2017). This action research study followed one teacher and eight emergent bilingual students during an intervention. The intervention consisted of asset projects developed from the funds of identity framework (Esteban-Guitart, 2016). The peer coaching process consisted of a period of observation followed by repeated co-planning, coteaching, and reflection. The researcher took a dialogical stance on creating asset projects with the students as well as peer coaching with the teacher …


The Graduate Record Examination And Graduate Admissions: Issues In Diversity, Lauren Rankin Dec 2022

The Graduate Record Examination And Graduate Admissions: Issues In Diversity, Lauren Rankin

Dissertations

Doctoral education is an expensive and difficult endeavor. Program faculty are interested in finding students who will be successful in completing their courses and obtaining employment. The Graduate Record Examination (GRE) is often used to assess a student’s readiness for the rigors of graduate education. A student’s readiness for doctoral education can be assessed through analyzing the predictive validity of the GRE with various outcomes such as grade point average, scholarly output, and time to completion. However, this measure may not predict success for all students with potential bias towards students who are international and linguistically diverse. A total of …


Educational Experiences That Influence The Upward Mobility Of Maya Women In Belize, Jennine Pettit Dec 2022

Educational Experiences That Influence The Upward Mobility Of Maya Women In Belize, Jennine Pettit

Dissertations

This qualitative, multicase study explored the relationship between the educative experiences that allowed some Maya women in Belize to overcome economic and cultural barriers and change the trajectory of their lives. Many Maya girls face indigeneity, rurality, and gender discrimination (Vásquez, 2017), and obtaining a meaningful education was very difficult. The overall question for this study asked how exceptional Maya women perceived the relationship between their educational experiences and their ability to achieve advancement in society? This study also addressed the following sub-questions: How do Maya women describe their journey toward success? What institutional, cultural, or economic obstacles confront Maya …


The Effect Of Hurricane Harvey On The Continuity Of Patient Care For Long-Term Care Patients Diagnosed With Dementia In Dallas And Harris Counties, Texas, Martin Mufich Dec 2022

The Effect Of Hurricane Harvey On The Continuity Of Patient Care For Long-Term Care Patients Diagnosed With Dementia In Dallas And Harris Counties, Texas, Martin Mufich

Dissertations

The purpose of this study was to analyze adverse health outcomes resulting from a disruption caused by Hurricane Harvey in the continuity of patient care for two geographically distinct patient populations: long-term care patients diagnosed with dementia in Dallas County, Texas and Harris County, Texas. Review of the literature revealed three themes: patient transitions from one level of care to another, members of the healthcare team (healthcare professionals, caregivers), and policies and strategies. The research design was a retrospective, quantitative, comparative, quasi-experimental design. The population of study consisted of long- term care patients diagnosed with dementia, N = 5,539. The …


Factors Influencing Political Self-Efficacy And Political Astuteness In Undergraduate Nurse Educators, Mark William Longshore Dec 2022

Factors Influencing Political Self-Efficacy And Political Astuteness In Undergraduate Nurse Educators, Mark William Longshore

Dissertations

The profession of nursing, 3.9 million strong, continues to lag in taking an active role in the development of health policy. Reasons for that include lack of time, a lack of knowledge, and perceived competence of political action. The factors of knowledge and the related perceived competence, or in the case of this study, self-efficacy, could be improved through education. To that end, it was important to identify if nurse educators had the political astuteness, or knowledge, and self-efficacy. If not, how would nurses learn the necessary skills and gain confidence to be more active politically? The purpose of this …


Person-Oriented And Variable-Oriented Statistical Approaches To Understanding At-Risk, Online High School Students: Predictions Of Academic Outcomes And The Moderating Role Of Protective Factors, Amanda Renee Atwater Jacobs Dec 2022

Person-Oriented And Variable-Oriented Statistical Approaches To Understanding At-Risk, Online High School Students: Predictions Of Academic Outcomes And The Moderating Role Of Protective Factors, Amanda Renee Atwater Jacobs

Dissertations

Many students come to school with risk factors that negatively impact their educational attainment and overall well-being. These risk factors may include but are not limited to abuse, poverty, teen pregnancy, low academic achievement, and learning disabilities. Other types of factors have been shown to provide a protective aspect against risk, and examples include social emotional skills such as grit, flexibility, and social-awareness. There is benefit in individualizing educational experiences for at-risk adolescents based on their specific risks and available protective factors, but knowing how these factors influence and interact with one another to predict academic outcomes is the first …


Political Astuteness Of Nurse Educators, Gail Marie Hanson Brenner Dec 2022

Political Astuteness Of Nurse Educators, Gail Marie Hanson Brenner

Dissertations

Nurses comprise the largest segment of the healthcare workforce. Although nurses have advocated for patients since Florence Nightingale’s time, advocating for changes in health policies that affect populations on a larger scale has not changed over time (Rasheed et al., 2020). Professional nursing associations, nurse educators, and the Institute of Medicine have all identified the need to educate nurses in advocacy and health policy. With the recent revision of the American Association of Colleges of Nursing’s Essentials publication, health policy has moved from an essential to a featured concept that is found in the competencies and subcompetencies of the domains. …


Putting Policy Into Practice: The Problematisation Of Catalan Language Planning And Ideologies In Media Discourse, Farah Ali Dec 2022

Putting Policy Into Practice: The Problematisation Of Catalan Language Planning And Ideologies In Media Discourse, Farah Ali

Global Language Studies Faculty publications

The revitalization of the Catalan language has been an ongoing effort in Catalonia for decades. The language policies that have stemmed from this effort have perpetuated ideologies that promote the use and legitimization of Catalan as both an official and a vehicular language. While this effort is widely regarded as an example of successful language revitalization, the process has not been without conflict between Spanish and Catalan, particularly in terms of domains of use and disparate attitudes towards the two languages (Newman & Trenchs-Parera, 2015; Woolard, 2016; Soler & Gallego-Balsà, 2019; Ianos et al., 2020). Given that these policies aim …


From The Editors, Robert Dinerstein, Jeremy R. Paul, Sonia E. Rolland, Ezra Rosser Dec 2022

From The Editors, Robert Dinerstein, Jeremy R. Paul, Sonia E. Rolland, Ezra Rosser

Journal of Legal Education

No abstract provided.