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Phase I Car-T Clinical Trials Review, Shaun Bulsara, Mengfen Wu, Tao Wang

Center for Medical Ethics and Health Policy Staff Publications

Background/aim: Chimeric antigen receptor (CAR) T cells with tumor specificity are being increasingly investigated. Phase I trials are the first step of testing for safety of novel CAR-T therapy to determine the maximum tolerated dose (MTD). Several dose escalation methods have been developed over time including rule-based, model-based, and model-assisted designs. The goal of this project is to overview the phase I designs used in current CAR-T trials.

Materials and methods: We searched PubMed for peer-reviewed literature published between January 1, 2015 and December 31, 2021. The search was limited to human studies in the English language using the keywords …

Incidence Of An Insulin-Requiring Hyperglycemic Syndrome In Sars-Cov-2-Infected Young Individuals: Is It Type 1 Diabetes?, Massimo Pietropaolo, Peter Hotez, Nick Giannoukakis

Center for Medical Ethics and Health Policy Staff Publications

Pancreatic ACE2 receptor expression, together with increased prevalence of insulin-requiring hyperglycemia in patients with coronavirus disease 2019 (COVID-19), suggested that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pancreatic infection might trigger a β-cell-selective inflammation precipitating autoimmune type 1 diabetes (T1D). We examined T1D incidence in patients with COVID-19 inside a large, global population using a "big data" approach. The incidence in 0-30-year-old patients with confirmed COVID-19 over an ∼15-month period from the beginning of the COVID-19 pandemic was compared with an age-matched population without COVID-19 inside the TriNetX COVID-19 Research Network (>80 million deidentified patient electronic medical records globally). …

A Novel, Brief, Fully Automated Intervention To Extend The Antidepressant Effect Of A Single Ketamine Infusion: A Randomized Clinical Trial, Rebecca B Price, Crystal Spotts, Benjamin Panny, Angela Griffo, Michelle Degutis, Nicolas Cruz, Elizabeth Bell, Kevin Do-Nguyen, Meredith L Wallace, Sanjay J Mathew, Robert H Howland

Staff and Researcher Publications

Objective: Intravenous ketamine, which displays rapid antidepressant properties, is posited to reverse depression by rapidly enhancing neuroplasticity. The authors tested whether an automated, computer-based approach could efficiently leverage enhanced neuroplasticity to extend the durability of rapid clinical response.

Methods: A total of 154 adults (ages 18-60) with treatment-resistant unipolar depression were randomized in a double-blind, parallel-arm design to receive an active/active treatment combination (ketamine plus active "automated self-association training" [ASAT]; N=53) or one of two control arms that lacked either the active drug component (saline plus active ASAT; N=51) or the active behavioral component (ketamine plus sham ASAT; N=50). One …

Human Loss-Of-Function Variants In The Serotonin 2c Receptor Associated With Obesity And Maladaptive Behavior, Yang He, Bas Brouwers, Hesong Liu, Hailan Liu, Katherine Lawler, Edson Mendes De Oliveira, Dong-Kee Lee, Yongjie Yang, Aaron R Cox, Julia M Keogh, Elana Henning, Rebecca Bounds, Aliki Perdikari, Vikram Ayinampudi, Chunmei Wang, Meng Yu, Longlong Tu, Nan Zhang, Na Yin, Junying Han, Nikolas A Scarcelli, Zili Yan, Kristine M Conde, Camille Potts, Jonathan C Bean, Mengjie Wang, Sean M Hartig, Lan Liao, Jianming Xu, Inês Barroso, Jacek Mokrosinski, Yong Xu, I Sadaf Farooqi

Children’s Nutrition Research Center Staff Publications

Serotonin reuptake inhibitors and receptor agonists are used to treat obesity, anxiety and depression. Here we studied the role of the serotonin 2C receptor (5-HT2CR) in weight regulation and behavior. Using exome sequencing of 2,548 people with severe obesity and 1,117 control individuals without obesity, we identified 13 rare variants in the gene encoding 5-HT2CR (HTR2C) in 19 unrelated people (3 males and 16 females). Eleven variants caused a loss of function in HEK293 cells. All people who carried variants had hyperphagia and some degree of maladaptive behavior. Knock-in male mice harboring a human loss-of-function HTR2C variant developed …

Factors That Influence School Nurses' Intent To Report Child Maltreatment, Catherine M. Jordan

Theses and Dissertations

Introduction: Child maltreatment is a global problem that causes harm to the well-being of a child that extends to adulthood. In the United States alone, there are 158,900 child victims in 2019 and 1,779 child fatalities. Despite national attention and the availability of child abuse education, the victimization statistics have remained essentially unchanged in the last 11 years. Nurses are mandated reporters of child maltreatment. School nurses are frequent observers in a child’s life, thus leaving them uniquely qualified for real-time assessment. The purpose of this study is to determine what factors correlate with the school nurse’s intent to report …

Anxiety Disorders In Children And Adolescents, Alicia Kowalchuk, Sandra J Gonzalez, Roger J Zoorob

Faculty, Staff and Students Publications

Anxiety disorders are the most common psychiatric conditions in children and adolescents, affecting nearly 1 in 12 children and 1 in 4 adolescents. Anxiety disorders include specific phobias, social anxiety disorder, separation anxiety disorder, agoraphobia, panic disorder, and generalized anxiety disorder. Risk factors include parental history of anxiety disorders, socioeconomic stressors, exposure to violence, and trauma. The U.S. Preventive Services Task Force recommends screening for anxiety disorders in children eight years and older; there is insufficient evidence to support screening in children younger than eight years. Symptoms of anxiety disorders in children and adolescents are similar to those in adults …

College Of Graduate Programs And Honors Studies Newsletter - December 2022, College Of Graduate Programs And Honor Studies, Wright State University

College of Graduate Programs and Honors Studies Newsletter

A six page newsletter created by the College of Graduate Programs and Honors Studies at Wright State University. This newsletter includes a upcoming events, message from the dean, and more.

An Unexpected Case Of Non-Uremic Calciphylaxis In A Patient With Multiple Risk Factors, Shannon Nugent, Fred Karaisz, Maisa Elbadawi, Andrew Touati, Neda Nikbakht, Jason B. Lee, Hasan Arif

Division of Internal Medicine Faculty Papers & Presentations

A 58-year-old woman with a history of morbid obesity, asthma, and prior warfarin use presented to the hospital with shortness of breath and a three-month history of painful, ulcerated ulcers with retiform purpura of her bilateral distal extremities. A punch biopsy specimen demonstrated focal necrosis and hyalinization of the adipose tissue with subtle arteriolar calcium deposition, findings consistent with calciphylaxis. We discuss the presentation of non-uremic calciphylaxis and review the risk factors, pathophysiology, and interdisciplinary management approach of this rare disease.

Girlhood And Engendered Alienation In The Heart Is A Lonely Hunter And A Tree Grows In Brooklyn, Lauren C. Dolese

LSU New Orleans Theses and Dissertations

Utilizing a girls’ studies perspective and materialist feminist lens, this paper seeks to put Carson McCullers’ The Heart is a Lonely Hunter (1940) in conversation with Betty Smith’s A Tree Grows in Brooklyn (1943). Besides being published in the early 1940s, both works feature young girls navigating class struggles, exploring their identities, and struggling against dominant ideologies specific to their time and place. McCullers’ and Smith’s novels depict how a patriarchal, capitalist society imposes upon young women a narrow, misogynistic view of themselves and the women around them—facilitating the social reproduction of oppression and alienation. In depicting these realities of …

Inclusive Job Descriptions Toolkit, Emily Frigo, Annie Bélanger, Kristin Meyer, Jason Durham, Brian Merry

Library Reports and Communication

The goal of the toolkit is to directly reflect our IDEA values and apply them to how we write job descriptions from start to finish for all positions in the Libraries. Supervisors, employees, and any key decision maker involved in the job description writing process should use this toolkit. The first part of the toolkit outlines best practices in developing job descriptions from both process and equity perspectives. The second part offers an equity lens to use to review the job descriptions. The Appendices include additional language, an implementation guide, and job description templates with instructions.

A Pilot Study Exploring The Potential Of Improv In Strengthening Youth–Adult Partnerships, Stephanie Begun, Brigette Mayorga, Cam Bautista, Krysta Cooke, Travonne Edwards, Bryn King, Hamzat Olaosebikan, Rae-Ann Whyte

Journal of Youth Development

This study qualitatively explored the potential of improv for strengthening youth–adult partnerships. Seven members of a youth-adult research collaborative participated in a 2-hour professionally facilitated improv workshop. Participants provided insights about their experiences through a follow-up qualitative interview questionnaire. Participants indicated that improv assisted in dismantling power differentials that often exist in youth–adult partnership contexts, also noting that improv helped them to express their true selves more readily, along with helping them to see new and more “human” sides to their team members. Participants were enthusiastic about accessing further improv opportunities, noting that improv should be embedded into other youth–adult …

Chapter 7: Social Health: Beyond Absence Of Social Isolation And Loneliness, Lihua Huang, Lisa Peterson

Books and Contributions to Books

This chapter examines social health beyond absence of social isolation and loneliness in aging. It employs critical gerontology and social determinants of health in analyzing social exclusion through age segregation and digital exclusion. It draws attention to personal social connectedness and institutional social inclusion among older adults experiencing multiple exclusion.

Social Equity Is Key To Sustainable Ocean Governance, Katherine M. Crosman, Edward H. Allison, Yoshitaka Ota, Andrés M. Cisneros-Montemayor, Gerald G. Singh, Wilf Swartz, Megan Bailey, Kate M. Barclay, Grant Blume, Mathieu Colléter, Michael Fabinyi, Elaine M. Faustman, Russell Fielding, P. Joshua Griffin, Quentin Hanich, Harriet Harden-Davies, Ryan P. Kelly, Tiff Annie Kenny, Terrie Klinger

Honors College Faculty Publications

Calls to address social equity in ocean governance are expanding. Yet ‘equity’ is seldom clearly defined. Here we present a framework to support contextually-informed assessment of equity in ocean governance. Guiding questions include: (1) Where and (2) Why is equity being examined? (3) Equity for or amongst Whom? (4) What is being distributed? (5) When is equity considered? And (6) How do governance structures impact equity? The framework supports consistent operationalization of equity, challenges oversimplification, and allows evaluation of progress. It is a step toward securing the equitable ocean governance already reflected in national and international commitments.

Perceptions Of Orthopaedic Medicine Students And Their Supervisors About Practice-Based Learning: An Exploratory Qualitative Study, Muhamed Nsubuga, Robert Opoka, Moses Galukande, Ian G. Munabi, Aloysius . Mubuuke, Sarah Kiguli

Paediatrics and Child Health, East Africa

Background: Practice-based learning is crucial in forming appropriate strategies for improving learning among the medical students that support the country’s understaffed health sector. Unsatisfactory learning consequently results in poor performance of students and poor quality of health care workforce in the long run. Exploring the perceptions about the current practice-based learning system and how to improve is thus vital. This study set out to explore the perceptions of Orthopaedic medicine students and their supervisors about practice-based learning at a tertiary training hospital.

Methods: This was an exploratory phenomenological qualitative study that involved in-depth interviews among 10 Orthopedic students during their …

Predictive Effects Of Poverty, Gender, Native Language Spoken, And Elpa21 Proficiency On Reading Performance, Carrie Bradow

College of Education Dissertations

The purpose of this dissertation was to determine the predictive effects of poverty, gender, native language spoken, and English Language Proficiency Assessment for the 21st Century (ELPA21) proficiency on reading performance measured by the ACT Aspire Summative Reading Assessment for Grades 4, 7, and 10 English language learners in a Northwest Arkansas school district. Through Bronfenbrenner’s ecological systems theory, the influence of poverty, gender, native language spoken, and ELPA21 proficiency were studied for influences on reading performance. Through a multiple regression analysis I examined the Spring 2019 state assessment and demographic data collected from over 20,000 student records. The findings …

The Relationship Between Anti-Müllerian Hormone, Body Mass Index And Weight Loss: A Review Of The Literature, Jacqueline Kloos, Rachel Weinerman

Student Scholarship

Anti-Müllerian hormone (AMH) is commonly used as a proxy for ovarian reserve due to its secretion by antral follicles. It is considered a metric for prediction of ovarian response to certain assisted reproduction therapies. As obesity has a negative impact on fertility, it is important to establish whether obesity-induced hormonal changes influence AMH levels, if and how weight loss affects AMH, and if that influence represents altered reproductive function. The aim of this study was to review the existing literature on the effects of body mass index and weight loss on AMH levels. A PubMed literature keyword search with relevant …

Transcriptomic Signal Of Reproductive Modes And Early Speciation In Daphnia Pulex-Pulicaria System, Trung Viet Huynh

Biology Dissertations - Archive

Daphnia have been gaining recognition as a key model system for studies of evolution, ecology, toxicology, and more recently genomics. The defining characteristic of this particular model system is its phenotypic plasticity and its responsiveness to environmental cues. At the same time, the advent of RNA sequencing technology has helped researchers gain new insights on the plasticity of gene expression and its role linking environmental cues with the physiological response mounted by the organism. Although many RNA-seq studies have been conducted in Daphnia, surprisingly no one has recorded the gene expression profile of one of Daphnia’s most famous phenotypic plastic …

Experiences Seeking, Sourcing, And Using Abortion Pills At Home In The United States Through An Online Telemedicine Service, Melissa Madera, Dana M. Johnson, Kathleen Broussard, Luisa Alejandra Tello-Pérez, Carol Armelle Ze-Noah, Aleta Baldwin, Rebecca Gomperts, Abigail R.A. Aiken

Faculty Publications

A growing number of people in the United States seek to self-manage their abortions by self-sourcing abortion medications online. Prior research focuses on people's motivations for seeking self-management of abortion and experiences trying to obtain medications. However, little is known about the experiences of people in the U.S. who actually complete a self-managed abortion using medications they self-sourced online. We conducted anonymous in-depth interviews with 80 individuals who sought abortion medications through Aid Access, the only online telemedicine service that provides abortion medications in all 50 U.S. states. Through grounded theory analysis we identified five key themes: 1) participants viewed …

Covid-19 Vaccination In Africa: A Case Of Unsatisfied Expectation And Ill-Preparedness, Osmond C. Ekwebelem, Phemelo Tamasiga, Abullhai Tunde Abonde, Ismaeel Yunusa Ph. D., Uju Nwauzoma, Helen Onyeaka

Faculty Publications

With a population of 1.3 billion people, of which 56% reside in rural settings, Africa seemed ill-prepared to handle the distribution of a COVID-19 vaccine. In addition, the capacity needed for a successful COVID- 19 vaccination campaign in Africa surpassed the available resources in local and state health agencies. As a result, African governments were advised to coordinate resources, health officials, and vaccinators, including local health practitioners, medical technicians, and pharmacists for the largest-ever vaccination campaign in Africa. Although the rolling out of the SARS-COV-2 vaccine was, as expected, slow in many African countries, and not yet enough to cover …

Acculturation And Social Media: How Do International Students Engage With Facebook While Abroad?

Journal of Comparative & International Higher Education

No abstract provided.

From 2000 To 2018: Examining The Relationship Between Net Tuition Revenue And The International Undergraduate Student Enrollment At Public Doctoral Universities

Journal of Comparative & International Higher Education

No abstract provided.

A Discourse Analysis Of Cheers, Paul Wiesenborn

Dissertations, Theses, and Projects

This paper analyzes the pragmatics features of the language in an episode of the sitcom Cheers to find out what second language learners need to know about the language of the sitcom and about the background knowledge informing it for that episode to be understandable to them and for it thus to be an effective as an instruction tool. To answer this question, the researcher transcribed the speech in the episode and used a speech act theory-based approach to identify and categorize deixis, locutionary forms, illocutionary types, and instances of reduction and types of indirect speech. Categories in these areas …

The Development Of Cultural Intelligence (Cq) In The Secondary Social Studies Classroom, Asha Gillette

Senior Honors Theses

Cultural competence is an important skill in our globalized world. Cultural Intelligence (CQ) is a good metric for cultural competence. CQ is used by businesses to improve cultural competence of their employees. There has been a lot of research on the development of CQ in undergraduate business students. Experiential teaching methods are the most effective in improving students’ CQ. CQ is a valuable skill for high school students to learn. The subject most appropriate to include training in CQ is social studies, and specifically World Geography. Pedagogical methods such as cultural interviews used in undergraduate business courses can also be …

The Dream Of Property: Law And Environment In William T. Vollmann’S Dying Grass And Leslie Marmon Silko’S Almanac Of The Dead, Ted Hamilton

Faculty Journal Articles

This article describes how the law inflects the narration of environmental conflict in William T. Vollmann’s Dying Grass (2015) and Leslie Marmon Silko’s Almanac of the Dead (1991). By focusing on the legal common sense of settler colonialism—its emphasis on private property in land and its subjugation of Indigenous peoples to the guardianship of the state—the article explores the ways in which Vollmann’s and Silko’s novels present counternarratives to the law’s story of justified conquest. Combining a law and literature approach with ecocriticism, this article highlights the importance of the legal imagination in defining human-land relations in the United States. …

A Substring Replacement Approach For Identifying Missing Is-A Relations In Snomed Ct, Xubing Hao, Rashmie Abeysinghe, Jay Shi, Licong Cui

Faculty, Staff and Student Publications

Biomedical ontologies provide formalized information and knowledge in the biomedical domain. Over the years, biomedical ontologies have played an important role in facilitating biomedical research and applications. Common quality issues of biomedical ontologies include inconsistent naming of concepts, redundant concepts, redundant relations, incomplete/incorrect concept definitions, and incomplete/incorrect class hierarchies. In this work, we focus on addressing the incompleteness of the class hierarchy in SNOMED CT. We develop a substring replacement approach, leveraging concepts’ lexical features and existing IS-A relations to identify potential missing IS-A relations in SNOMED CT. To evaluate the effectiveness of our approach, we performed both automated and …

Character First: Defining And Methodizing Character Depth, Jeff Mason

Criterion: A Journal of Literary Criticism

This paper explores the definition of "depth" in characters and provides a radical new definition, supplemented by an applicable model. By looking into significant literary theory, contemporary works of story, and even elements of mathematics, this paper advances our understanding of characters and how they create meaning in stories.

Marriage And Relationships In Art Spiegelman’S Maus: The Erasure Of The Female Experience, Gretchen K. Picklesimer Kinney

Criterion: A Journal of Literary Criticism

In this paper, the author explores how Vladek’s focus on money, control, and independence creates an imbalance of power in his romantic relationships with Luica, Anja, and Mala. She explores Vladek’s motivations for continuing (or not continuing) these relationships, and how Vladek tries to maintain power and control. She analyzes how Vladek ignores the perspectives and experiences of these women to create his own biased narrative of the relationships.

Pedagogies And Practices Of Teaching Girlhood Studies, Emily R. Aguiló-Pérez, Jacqueline Reid-Walsh

English Faculty Publications

Girlhood Studies, as an academic discipline, is continually growing. Since some educational institutions include girls’ studies as part of a special curriculum, an academic program, a certificate course, a minor, or as part of Women’s Studies or Gender Studies, Girlhood Studies has a presence in academia although at this stage rarely in an autonomous department. This interest in the pedagogies and practices of teaching Girlhood Studies is an important aspect of its growth as a field of study not only at the university level but also in other academic settings and outside of them, be they workshops, special programs for …

Machine Learning-Based Methods For The Segmentation Of Scanning Electron Microscopy Images Of Fine-Grained Shale Samples, Binqian Yin

Earth & Environmental Sciences Dissertations - Archive

The segmentation of scanning electron microscopy (SEM) images is critical yet time-consuming for geological studies, as it will need to differentiate the boundaries for different mineral objects to facilitate subsequent analyses, such as porosity calculation. Recently, machine learning methods, especially convolutional neural networks (CNNs), have been explored to segment SEM images for fine-grained shale samples. However, existing methods fail to address two critical issues in the segmentation of shale rock images---insufficient labeled data and imbalanced objects. To this end, this dissertation has proposed a machine learning pipeline that consists of supervised, semi-supervised, and active learning stages to reduce manual efforts …

Autonomous Teaming Of Multileader System - Robust Cluster Formation Approach, Maryam N. Naleini

Electrical Engineering Dissertations - Archive

The cluster consensus problem of Multileader MAS Is considered and the clustering problem of interconnected multileader systems is formulated as a disturbance attenuation problem. For the first time, it's proved that the multileader MAS can reach cluster consensus without limiting the communication between the clusters. The combination of Small Gain Theorem and H8 optimization has been designed in the graphical differential game platform to prove the stability for the system. At the end, an online off-policy reinforcement learning algorithm is developed to find the solution to the H8 optimal problem of multileader MAS with completely unknown systems.