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Complexity Of Progranulin Mechanisms Of Action In Mesothelioma, Elisa Ventura, Christopher Xie, Simone Buraschi, Antonino Belfiore, Renato V. Iozzo, Antonio Giordano, Andrea Morrione

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Background: Mesothelioma is an aggressive disease with limited therapeutic options. The growth factor progranulin plays a critical role in several cancer models, where it regulates tumor initiation and progression. Recent data from our laboratories have demonstrated that progranulin and its receptor, EphA2, constitute an oncogenic pathway in bladder cancer by promoting motility, invasion and in vivo tumor formation. Progranulin and EphA2 are expressed in mesothelioma cells but their mechanisms of action are not well defined. In addition, there are no data establishing whether the progranulin/EphA2 axis is tumorigenic for mesothelioma cells.

Methods: The expression of progranulin in various mesothelioma cell …

Healing In Nurses After Assignment In Natural Disasters, Fitriana Kurniasari Solikhah, Ronal Surya Aditya

Folia Medica Indonesiana

Highlight : • Disasters impact a large number of people, including nurses who are deployed in the disaster relief. • Culturally sensitive psychological first aid sessions, post-assignment in crisis situations monitoring, and grit have implications in pushing the nurses to overcome their trauma and obstacles. • Government policies are also important in helping nurses to heal after deployment in disaster relief. Abstract : Disasters are defined as catastrophic occurrences that impact a large number of people quickly and with an abrupt onset. On average, one natural disaster is reported globally each day. However, the impact of a traumatic occurrence on …

Back Matter Vol.58 No.4 December 2022, Folia Medica Indonesiana

Folia Medica Indonesiana

Back Matter Vol.58 No.4 December 2022

Ic 013 Guide To University Of Texas School Of Public Health Records, 1970-1995; 1967-2008, University Of Texas Health Science Center At Houston. School Of Public Health

Institutional Finding Aids

The University of Texas School of Public Health (SPH) records contains records from the School, as well as related programs and topics. The majority of the collection is made up of copies of the SPH Calendar from 1978-1983 and the SPH Catalog from 1971-1995. See more at IC 013.

Ipv6 Security Issues: A Systematic Review Following Prisma Guidelines, Shubair A. Abdullah, Ahmed A. Al Ashoor

Baghdad Science Journal

Since Internet Protocol version 6 is a new technology, insecure network configurations are inevitable. The researchers contributed a lot to spreading knowledge about IPv6 vulnerabilities and how to address them over the past two decades. In this study, a systematic literature review is conducted to analyze research progress in IPv6 security field following the Preferred Reporting Items for the Systematics Review and Meta-Analysis (PRISMA) method. A total of 427 studies have been reviewed from two databases, IEEE and Scopus. To fulfil the review goal, several key data elements were extracted from each study and two kinds of analysis were administered: …

Land Use Change In Baghdad City And Assessment Of The Jadriyah And Umm Al- Khanazeer Island Important Bird Area (Iba) From 1984 To 2020, Nadheer A. Fazaa, Abdulrahman B. Ali, Ahmad Jm Al-Jabinawi, Richard Francksen, Mark J. Whittingham

Baghdad Science Journal

Land use change, particularly the expansion of urban areas and associated human activities at the expense of natural and semi-natural areas, is a major ecological issue in urban areas around the world. Climate change being a very strong additional driver for changing the temperature and habitat in the cities. This also applies to Baghdad, Iraq, where urbanisation and climate change exerts a major pressure on the natural habitats of the city, and thus may affect the ability of city planners to adapt to future climate change scenarios. Here we present evidence of substantial growth in urban areas, increases in temperature, …

Short Text Semantic Similarity Measurement Approach Based On Semantic Network, Naamah Hussien Hameed, Adel M. Alimi, Ahmed T. Sadiq

Baghdad Science Journal

Estimating the semantic similarity between short texts plays an increasingly prominent role in many fields related to text mining and natural language processing applications, especially with the large increase in the volume of textual data that is produced daily. Traditional approaches for calculating the degree of similarity between two texts, based on the words they share, do not perform well with short texts because two similar texts may be written in different terms by employing synonyms. As a result, short texts should be semantically compared. In this paper, a semantic similarity measurement method between texts is presented which combines knowledge-based …

Advisement Challenges And Opportunities In Pre-Service Teacher Education: Insights Into The Experiences Of Diverse Pre-Service Teachers, Latasha Casterlow-Lalla

Seton Hall University Dissertations and Theses (ETDs)

Effective pre-service teacher educator programs are among the most important components in preparing the nation’s next generation of educators. Today’s educators collectively work to support the diverse cultural, linguistic, and social needs of students through the unprecedented demands of a transitioning school system. This dissertation examined the components of advisement challenges and opportunities as an impact on the preparation of pre-service teachers in Northern New Jersey. The study explored the influence of approaches available to pre-service teachers in the areas of program structure, a variety of support services, and the role of the advisor-advisee relationship to discover whether such programs …

Forecasting Ride-Hailing Across Multiple Model Frameworks, Christopher Stephen Day

Theses and Dissertations

The advent of on-demand transport modes such as ride-hailing and microtransit has challenged forecasters to develop new methods of forecasting the use and impacts of such modes. In particular, there is some professional disagreement about the relative role of activity-based transportation behavior models -- which have detailed understanding of the person making a trip and its purpose -- and multi-agent demand simulations which may have a better understanding of the availability and service characteristics of on-demand services. A particular question surrounds how the relative strengths of these two approaches might be successfully paired in practice. Using daily plans generated by …

The Cycle Of Book Publishing Through A Queer Lens, Aly Gilmore

Master of Arts in Professional Writing Capstones

This capstone assesses the current landscape of the publishing industry with regard to Queer authors and stories that have been published within the United States. It will start off with a literature review utilizing secondary research upon the current publishing landscape, as well as the rules that guide how writing craft is constructed and taught. Within this section, I also unpack personal experiences from working in a local bookstore as well as integrating some information from interviews from individuals with connections to the publishing industry. It will conclude with an autoethnography, in which I reflect how my own experiences intertwine …

Tiptoeing Through The Tulips At Seventy: A Memoir, Fran Miele

Master of Arts in Professional Writing Capstones

This is a memoir about my lifetime search for clarity about my gender identity. My primary goal for the project was to catalog the steps I took in the sometimes-tortured and confusing path I followed over the course of my life, from childhood to late adulthood, striving to understand who and what I am in terms of my identity and how, once it was clarified in my mind, coming to terms with it and, at the ripe old age of seventy, taking the steps necessary to affirm it by way of the male-to-female transition. A secondary, incidental goal was …

Courier Of Souls, Brian Cochran

Master of Arts in Professional Writing Capstones

Abriel is a courier in a world plagued by curses cast by spiteful deities, and the only safe haven from curses are the roads themselves, which cause curses to burn. Following in her father’s footsteps, she strives to match his skills as a courier, and respect the legacy of her adoptive father, who saved her from a life of abandonment and rejection.

There's A Hole In My Heart: A Case Of An Unrepaired Vsd, Brittany Hartman, Alex Dwyer, Robert Dejoy

Einstein Health Papers

No abstract provided.

Efficacy And Safety Of Pacritinib Vs Placebo For Patients With Severe Covid-19: A Phase 2 Randomized Clinical Trial, John Cafardi, Carole Miller, Howard Terebelo, Chad Tewell, Sadia Benzaquen, David Park, Pamela Egan, Daniel Lebovic, Kristen Pettit, Eric Whitman, Douglas Tremblay, Jonathan Feld, Sarah Buckley, Karisse Roman-Torres, Jennifer Smith, Adam Craig, John Mascarenhas

Einstein Health Papers

IMPORTANCE: The morbidity and mortality associated with COVID-19 remain high despite advances in standard of care therapy, and the role of anti-inflammatory agents that inhibit the interleukin 6/JAK2 pathway is still being elucidated.

OBJECTIVE: To evaluate the efficacy and safety of the oral JAK2/IRAK1 inhibitor pacritinib vs placebo in the treatment of adults with severe COVID-19.

DESIGN, SETTING, AND PARTICIPANTS: This phase 2, double-blind, placebo-controlled, randomized clinical trial enrolled hospitalized adult patients with severe COVID-19 at 21 centers across the US between June 2020 and February 2021, with approximately 1.5 months of safety follow-up per patient. Data analysis was performed …

Safety And Efficacy Of Salvage Therapy With Laser Interstitial Thermal Therapy For Malignant Meningioma Refractory To Cesium-131 Brachytherapy: Illustrative Case, Clifford Yudkoff, Aria Mahtabfar, Keenan Piper, Kevin Judy

Department of Neurosurgery Faculty Papers

BACKGROUND

Anaplastic meningioma are rare, cancerous tumors of the central nervous system that often require multimodal therapy for tumor control. Both laser interstitial thermal therapy (LITT) and brachytherapy with implanted cesium-131 metallic seeds have demonstrated efficacy in the treatment of recurrent and resistant anaplastic meningioma; however, their safety as a dual therapy has never been reported.

OBSERVATIONS

In this report, the authors present a case of a 53-year-old female who received LITT in combination with brachytherapy after surgical and radiation treatment options had been exhausted. The authors discuss the unique safety concern of thermal injury with this treatment combination and …

A Rebel Territory Behind The Tourist Scene: Negotiating National Belonging And Indigeneity In Quintana Roo, Mélissa Elbez

Maya America: Journal of Essays, Commentary, and Analysis

When we think of tourism or migration, we think of international mobility. However, the history of Quintana Roo teaches us that tourism and migration can be forces of nationalization. This article invites us to revisit the history of the southeast Yucatan peninsula, in order to understand the mechanisms that presided over its inclusion into the Mexican nation and the logic of the resistance movement that was opposed to it. Furthermore, this article delves into the ritual practices, social organization and territoriality inherited from the Cast War, that are kept alive by the rebels’ descendants (Cruzoob), unbeknownst to the gaze of …

Brave Storytelling: Diasporic Indigenous Students, Vulnerability, And The Arts, Luis Javier Pentón Herrera

Maya America: Journal of Essays, Commentary, and Analysis

In this article, I explore how vulnerability is imposed on diasporic Indigenous students in U.S. classrooms and how, through the arts, language and literacy educators can remove these vulnerabilities. For this, I weave elements of storytelling to first introduce Mariela and diasporic Indigenous students. Then, I share two examples of how my diasporic Indigenous students used poetry and drawing in our high school English for Speakers of Other Languages (ESOL) classroom to overcome vulnerabilities imposed on them by our school system. For clarification, throughout this manuscript, I use the term diasporic Indigenous students to describe Indigenous students who migrated to …

Introduction: Tourism In The Lands Of The Maya, Cristina Oehmichen

Maya America: Journal of Essays, Commentary, and Analysis

English Introductory Note

Moravians Amongst The Cherokees: An Account Of The Springplace Mission, Ethan T. Smith

Doctoral Dissertations and Projects

This work is a study of the relationships that were built between two people groups that resulted in a harmonious culture being established between the Cherokees and the Moravians during the 19th century. Often, too little credit is given to the Moravians for their work amongst the Cherokees during a most tumultuous period for the Natives, however, this work highlights the cultural barriers that were broken as a result of the labor undertaken by the Brethren at Springplace, Georgia on James Vann’s Diamond Hill Plantation at the turn of the 19th century. Furthermore, this study concludes by showcasing the lasting …

Influence Of Silver And Copper Nanoparticles On The Enzymatic Activity Of Soil-Borne Microorganisms, Lyudmila I Zaynitdinova, Roxila N Juraeva, Javlon J Tashpulatov, Svetlana I Kukanova, Nikolay A Lazutin, Aziza M Mavjudova

Baghdad Science Journal

Influence of metal nanoparticles synthesized by microorganisms upon soil-borne microscopic fungus Aspergillus terreus K-8 was studied. It was established that the metal nanoparticles synthesized by microorganisms affect the enzymatic activity of the studied culture. Silver nanoparticles lead to a decrease in cellulase activity and completely suppress the amylase activity of the fungus, while copper nanoparticles completely inhibit the activity of both the cellulase complex and amylase. The obtained results imply that the large-scale use of silver and copper nanoparticles may disrupt biological processes in the soil and cause change in the physiological and biochemical state of soil-borne microorganisms as well.

Proposed Framework For Official Document Sharing And Verification In E-Government Environment Based On Blockchain Technology, Rana F. Ghani, Asia Ali Salman Al-Karkhi, Shakir Mahmood Mahdi

Baghdad Science Journal

Progression in Computer networks and emerging of new technologies in this field helps to find out new protocols and frameworks that provides new computer network-based services. E-government services, a modernized version of conventional government, are created through the steady evolution of technology in addition to the growing need of societies for numerous services. Government services are deeply related to citizens’ daily lives; therefore, it is important to evolve with technological developments—it is necessary to move from the traditional methods of managing government work to cutting-edge technical approaches that improve the effectiveness of government systems for providing services to citizens. Blockchain …

Complete Issue: Volume 4 Issue 2, Cristina Oehmichen, Adriana Cruz-Manjarrez

Maya America: Journal of Essays, Commentary, and Analysis

The full Issue 2, Volume 4 of Maya America, published December 2022

Prince Jaguar, Ismael Briceño Mukul

Maya America: Journal of Essays, Commentary, and Analysis

“Prince Jaguar” is an original poem by Ismael Briceño Mukul, a well-known Maya poet and scholar. This poem in English has been translated from the Yucatec Maya that also appears in this issue of Maya America.

Seated On The Bank Of The Yichk’U River, Daniel Caño

Maya America: Journal of Essays, Commentary, and Analysis

The six poems included here are presented in Q’anjob’al Maya and in English, side by side for language comparison. Collectively, the poems convey reflections on the poet’s renderings of beauty, wisdom, romance, and the natural world; in a style of eloquence amplified by directness and brevity. Glimpses of village, family, childhood and old age, life and death, are interwoven with cosmological wisdoms. Palpable resentment toward the Church and ladinos are graciously tempered with lightness and humor. Reprinted from “Sentado en la orilla del río Yichk’u “ POE Talleras, (2018) Huehuetenango, Guatemala, with permission from the author and publishers.

The Relationship Between Rightness, Religiosity, And Marital Satisfaction Among Christian Spouses In The United States, Juan Arturo Paulino

Doctoral Dissertations and Projects

Marital satisfaction is paramount to a loving and long-lasting married life. The absence of marital satisfaction can lead to poor health, relational stress, and, eventually, divorce. This predictive, correlational study sought to research the relationship between the adoption of a position of rightness, the practice of extrinsic religiosity, and how these factors influence the levels of marital satisfaction among Christian spouses in the United States of America. The researcher used the Brief Version of the Religious Orientation Scale- Revised (ROS-R) to assess the level of intrinsic and extrinsic religious activity of the sample population. To measure the independent variable of …

Comparing The Academic Growth Among Black Students In Philadelphia’S Black-Operated Charter Schools, Non-Black Operated Charter Schools, And Traditional Public Schools., Cherryann M. Joseph

Doctoral Dissertations and Projects

This ex post facto, causal-comparative quantitative study assessed the math and English language arts (ELA) 7th to 8th-grade academic growth among Black students enrolled in Philadelphia’s black-operated public charter schools, non-black operated charter schools, and traditional public schools while controlling for 6th-grade exam scores. Over 65 years after Brown versus Board of Education disallowed public school segregation, the academic achievement gap between Black and white students persists. Various parental and educational stakeholders have considered charter public schools as suitable educational alternatives for narrowing this academic gap. This condition along with an assertion by some community activists that Black leaders are …

Characteristics That Make An Excellent Worship Leader According To The Perspectives Of Baptist Congregants In North Texas, Carlos Jerome Benson

Masters Theses

Despite many Baptists Churches in North Texas, most church congregants vary significantly in how they characterize an excellent worship leader. These congregants often rely on trial and error to establish characteristic traits that are acceptable for the whole of a particular church. There is a gap in the research study of characteristics that make an excellent worship leader according to the perspectives of Baptist congregants in North Texas. This study will find which attributes of worship leadership are most desirable according to the views of North Texas Baptist congregants. These literary examples do not specifically name what characteristics North Texas …

An Education Intervention Project In Community Clinics To Improve The Identification Of Patients With Pulmonary Alveolar Proteinosis And To Correctly Identify The Type Utilizing The Differential Diagnostic Algorithm, Catherine J. Poisson

Doctoral Dissertations and Projects

With over 7000 types, rare diseases affect 25-30 million Americans and contribute to over one trillion dollars in healthcare-related costs. Prescribers lack the knowledge to improve awareness, identification, and treatment of rare diseases. Pulmonary alveolar proteinosis is a rare disease in which patients present with symptoms such as dyspnea, fatigue, and respiratory infections. Diagnosis can take four to 92 months. A differential diagnostic algorithm published in the literature can guide clinicians in identifying the type of pulmonary alveolar proteinosis the patient has. In addition, if the clinicians perform a laboratory test called the granulocyte-macrophage autoantibody test, this test provides 100% …

Selective Vulnerability Of The Intermediate Retinal Capillary Plexus Precedes Retinal Ganglion Cell Loss In Ocular Hypertension, Priyamvada M Pitale, Guofu Shen, Rohini R Sigireddi, Maria Polo-Prieto, Yong H Park, Solomon E Gibson, Peter D Westenskow, Roomasa Channa, Benjamin J Frankfort

Faculty, Staff and Students Publications

Introduction: Glaucoma, a disease of retinal ganglion cell (RGC) injury and potentially devastating vision loss, is associated with both ocular hypertension (OHT) and reduced ocular blood flow. However, the relationship between OHT and retinal capillary architecture is not well understood. In this project, we studied microvasculature damage in mice exposed to mild levels of induced OHT.

Methods: Mild OHT was induced with the microbead model for 2 weeks. At this time point, some retinas were immunostained with CD31 (endothelium), Collagen IV (basement membrane), and RBPMS (RGCs) for z-stack confocal microscopy. We processed these confocal images to distinguish the three retinal …

Implementation Of Provider Education Regarding Exercise As Adjunctive Treatment For Common Mental Health Diagnoses, Lauren Grace Martin

Doctoral Dissertations and Projects

Mental and physical health are inextricably linked. The advent of the Covid-19 pandemic reduced physical activity levels while worsening mental health symptoms. Pharmacological treatments are frequently used to treat mental health conditions; however, side effects can worsen metabolic issues. There is significant evidence that exercise can improve mental health conditions. The purpose of this project was to utilize provider education as an intervention to increase the use of exercise as an adjunctive treatment in the psychiatric treatment plan. This project was implemented at Nevada Mental Health, an outpatient behavioral health clinic in Las Vegas, Nevada. The investigator conducted a chart …