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2022

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Noted With Honor: Intersections Between Theology, Music Therapy, Psychotherapy, And Original Music Compositions For Hospice Patients, Stanton Nelson Dec 2022

Noted With Honor: Intersections Between Theology, Music Therapy, Psychotherapy, And Original Music Compositions For Hospice Patients, Stanton Nelson

Doctor of Pastoral Music Projects and Theses

This thesis investigates the intersections between theology, music therapy, and psychotherapy when creating a music composition that honors a hospice patient’s walk of faith. A pioneer organization inspiring this thesis is Swan Songs in Austin, Texas, where musical moments are created for the patient and family. However, its model is primarily based on collating previously composed pieces for recitals without a personalized honoring of the patient’s witness of faith. Noted with Honor is an emerging non-profit organization that creates an original work that reflects upon the testimony of the patient and forms a new narrative towards the end of one’s …


The Hypertension Cascade Of Care In The Midst Of Conflict: The Case Of The Gaza Strip, Bassam A. Abu Hamad, Zeina Jamaluddine, Gloria Safadi, Marie Elizabeth Ragi, Raeda El Sayed Ahmad, Eszter P. Vamos, Sanjay Basu, John S. Yudkin, Mohammed Jawad, Christopher Millett, Hala Ghattas Ph.D. Dec 2022

The Hypertension Cascade Of Care In The Midst Of Conflict: The Case Of The Gaza Strip, Bassam A. Abu Hamad, Zeina Jamaluddine, Gloria Safadi, Marie Elizabeth Ragi, Raeda El Sayed Ahmad, Eszter P. Vamos, Sanjay Basu, John S. Yudkin, Mohammed Jawad, Christopher Millett, Hala Ghattas Ph.D.

Faculty Publications

Although hypertension constitutes a substantial burden in conflict-affected areas, little is known about its prevalence, control, and management in Gaza. This study aims to estimate the prevalence and correlates of hypertension, its diagnosis and control among adults in Gaza. We conducted a representative, cross-sectional, anonymous, household survey of 4576 persons older than 40 years in Gaza in mid-2020. Data were collected through face-to-face interviews, anthropometric, and blood pressure measurements. Hypertension was defined in anyone with an average systolic blood pressure ≥140 mmHg or average diastolic blood pressure ≥90 mmHg from two consecutive readings or a hypertension diagnosis. The mean age …


A Lexical Analysis Of The Verb Of Perception Bona (See) In Setswana, Andy Chebanne Dec 2022

A Lexical Analysis Of The Verb Of Perception Bona (See) In Setswana, Andy Chebanne

Journal of Humanities and Social Sciences

The verb ‘BONA’ (to see) in Setswana represents semantic entailments that are not included in the general entailments that the verb of most perceptions UTLWA (perceive – taste, hear, comprehend, smell, feel) presents. The critical question is what is the basis of the exclusion of BONA from the semantic entailments found in UTLWA? To respond to this question, it is important to examine and characterize the semantic domains of BONA. This verb demonstrates some interesting polysemism when used in different syntactic contexts. The paper will first present the verbs of perceptions in Setswana and their semantic relationships. Further, it will …


The Persuasive Effect Of Legitimation Campaign Discourse, Kelvin Mathayo Lukanga Dec 2022

The Persuasive Effect Of Legitimation Campaign Discourse, Kelvin Mathayo Lukanga

Journal of Humanities and Social Sciences

This paper is concerned with the persuasive effect of legitimation discourse on Tanzanians’ voting decisions. It examines how former President Jakaya Mrisho Kikwete and Dr Wilbroad Slaa deployed language during the 2010 presidential election campaign to elicit support from the electorate. It also looks at non-discursive/non linguistic factors that influenced the same decisions. The data analysed in this paper is from some of their campaign speeches, and from focus group discussions as well. In analysing the data and discussing the findings, the study draws on Theo van Leeuwen’s semantic-functional approach to critical discourse analysis (henceforth CDA). The results show that …


Total Hip Arthroplasty In Patients With Neurological Conditions: A Systematic Review, Conor S O'Driscoll, Andrew J Hughes, Martin S Davey, Joseph M Queally, Brendan J O'Daly Dec 2022

Total Hip Arthroplasty In Patients With Neurological Conditions: A Systematic Review, Conor S O'Driscoll, Andrew J Hughes, Martin S Davey, Joseph M Queally, Brendan J O'Daly

Rothman Institute Papers

Background: As operative techniques and implant design have evolved over time, total hip arthroplasty (THA) is increasingly being carried out for patients with neurological impairment. This patient group places unique surgical challenges to the arthroplasty surgeon, which may include contractures, instability, and altered muscular tone. The purpose of this systematic review is to report the patient outcomes, complications, and implant survival following THA for patients with neurological conditions affecting the hip. Thus, we aim to support orthopaedic surgeon decision-making when considering and planning THA for these patients.

Methods: A systematic review was performed as per Preferred Reporting Items for Systematic …


Pre-Existing Diabetes Mellitus, Hypertension And Kidneydisease As Risk Factors Of Pre-Eclampsia: A Disease Of Theories And Its Association With Genetic Polymorphism, Abdullah Salah Alanazi, Francis Victor, Kanwal Rehman, Yusra Habib Khan, Ismaeel Yunusa Ph.D., Abdulaziz Alzarea, Muhammad Sajid Hamid Akash, Tauqeer Hussain Mallhi Dec 2022

Pre-Existing Diabetes Mellitus, Hypertension And Kidneydisease As Risk Factors Of Pre-Eclampsia: A Disease Of Theories And Its Association With Genetic Polymorphism, Abdullah Salah Alanazi, Francis Victor, Kanwal Rehman, Yusra Habib Khan, Ismaeel Yunusa Ph.D., Abdulaziz Alzarea, Muhammad Sajid Hamid Akash, Tauqeer Hussain Mallhi

Faculty Publications

Pre-existing diabetes, hypertension and kidney disorders are prominent risk factors of pre-eclampsia (PE). It is a multifactorial pregnancy disorder associated with high blood pressure, proteinuria, and multiorgan failure, which develops after the 20th week of pregnancy. It is one of the most feared pregnancy disorders, as it consumes thousands of fetomaternal lives per annum. According to clinical and pathological studies, the placenta appears to be a key player in the pathogenesis of PE; however, the exact origin of this disorder is still under debate. Defective placentation and angiogenesis are the hallmarks of PE progression. This angiogenic imbalance, together with maternal …


Whalesong 2022-12-01 (V.42 No.5), Mike Flunker, Aj Schultz, Lucas Stewart, Teigan Akagi, Liz Fruechtnict, Carrie Kline, Shaelene Moler, Olive Brend Dec 2022

Whalesong 2022-12-01 (V.42 No.5), Mike Flunker, Aj Schultz, Lucas Stewart, Teigan Akagi, Liz Fruechtnict, Carrie Kline, Shaelene Moler, Olive Brend

Whalesong

No abstract provided.


Teacher Decision Making In Teaching About The Holocaust Through Art, Julie Bell, Connie Schaffer, Kimberly Gangwish Dec 2022

Teacher Decision Making In Teaching About The Holocaust Through Art, Julie Bell, Connie Schaffer, Kimberly Gangwish

Teacher Education Faculty Publications

The primary objective of this comparative case study was to explore how secondary teachers make decisions regarding teaching about the Holocaust using the art of Samuel Bak as text. The researchers analyzed self-created curriculum materials, responses to a questionnaire about teacher decision-making processes, and interviews with three secondary teachers whose students visited an exhibit of Bak’s art. The researchers find that teachers have agency to make decisions based on materials, standards and curriculum, and personal connections to the content while relying on a student-centered approach. Implications for further research include a deeper exploration of teachers’ awareness of their decision making.


Designing For Best Use Of The Downtown I-345 Corridor In Dallas, Tx: Stakeholder Perspectives, Matthew Thornton Dec 2022

Designing For Best Use Of The Downtown I-345 Corridor In Dallas, Tx: Stakeholder Perspectives, Matthew Thornton

Landscape Architecture Masters & Design Theses - Archive

What is a city? It’s more than a location where many people live and work. It is a conglomeration of shared experience over generations. One generation informs the next, which informs how each subsequent generation adds to the development of their shared home. This is what gives each city its own unique form, character, and identity. But what happens if a city repeatedly outgrows itself, disconnects its communities, and demolishes the physical memory of its own cultural history? Dallas, Texas is one such city confronting these issues and is perceived as one without significant place memory or culture (if not …


Clinical Characteristics And Electrophysiologic Properties Of Scn5a Variants In Fever-Induced Brugada Syndrome, Gan-Xiao Chen, Hector Barajas-Martinez, Giuseppe Ciconte, Cheng-I Wu, Michelle M Monasky, Hao Xia, Bian Li, John A Capra, Kai Guo, Zhong-He Zhang, Xiu Chen, Bo Yang, Hong Jiang, Gary Tse, Chloe Miu Mak, Yoshiyasu Aizawa, Michael H Gollob, Charles Antzelevitch, Arthur A M Wilde, Carlo Pappone, Dan Hu Dec 2022

Clinical Characteristics And Electrophysiologic Properties Of Scn5a Variants In Fever-Induced Brugada Syndrome, Gan-Xiao Chen, Hector Barajas-Martinez, Giuseppe Ciconte, Cheng-I Wu, Michelle M Monasky, Hao Xia, Bian Li, John A Capra, Kai Guo, Zhong-He Zhang, Xiu Chen, Bo Yang, Hong Jiang, Gary Tse, Chloe Miu Mak, Yoshiyasu Aizawa, Michael H Gollob, Charles Antzelevitch, Arthur A M Wilde, Carlo Pappone, Dan Hu

Division of Cardiology Faculty Papers

Background: Brugada syndrome (BrS) is a severe inherited arrhythmia syndrome that can be unmasked by fever.

Methods: A multicentre clinical analysis was performed in 261 patients diagnosed with fever-induced BrS, including 198 (75.9%) and 27 (10.3%) patients who received next-generation genetic sequencing and epicardial arrhythmogenic substrate (AS) mapping, respectively.

Findings: In fever-induced BrS patients, pathogenic or likely pathogenic (P/LP) SCN5A variant carriers developed fever-induced BrS at a younger age, and more often in females and those of Caucasian descent. They exhibited significant electrophysical abnormalities, including a larger epicardial AS area, and more prolonged abnormal epicardial electrograms. During a median follow-up …


The Common Law As Statutory Backdrop, Anita S. Krishnakumar Dec 2022

The Common Law As Statutory Backdrop, Anita S. Krishnakumar

Georgetown Law Faculty Publications and Other Works

Amidst the whirl of commentary about how the U.S. Supreme Court has become increasingly textualist and what precise shape modern textualism should take, the Court’s continued reliance on one decidedly atextual interpretive tool has gone largely unnoticed — the common law. Indeed, the common law has played an underappreciated, often dispositive, gap-filling role in statutory interpretation for decades, even as the textualist revolution has sidelined other non-text-focused interpretive tools. But despite the persistent role that the common law has played in statutory interpretation cases, the use of common law rules and definitions as an interpretive resource is surprisingly understudied and …


Parental Warmth And Disciplinary Strategies In Two-Parent-Adoptive And Biological Families, Jordan Coburn Dec 2022

Parental Warmth And Disciplinary Strategies In Two-Parent-Adoptive And Biological Families, Jordan Coburn

Theses and Dissertations

Adopted children enter families with parents who on average are older, have higher income, and have more education than other family structures. Because adopted children are moving into families with more resources, research suggests that they would do just as well as, and perhaps even better than, children in biological two-parent households. However, this is not always the case. Understanding how different variables could offset any negative results of adoption is a puzzle that researchers are continually exploring. Previous research has investigated differences in investments from adoptive and biological parents through multiple theoretical lenses. I seek to add to current …


Does Predation Environment Affect Repeated Responses To Predation Cuesâ In The Fishâ Brachyrhaphis Rhabdophora?, Madeleine S. Nate Dec 2022

Does Predation Environment Affect Repeated Responses To Predation Cuesâ In The Fishâ Brachyrhaphis Rhabdophora?, Madeleine S. Nate

Theses and Dissertations

Individual organisms face trade-offs when dealing with predation—more time spent avoiding predators often results in less time allocated to energy acquisition and reproductive-related activities. Individuals that optimize this trade-off and respond appropriately to current risk levels in their environment should be at an advantage. What is less clear is whether this tradeoff changes when individuals are repeatedly exposed to a predation threat. There may be advantages to responding consistently to every signal of threat, but it might also be advantageous to modulate individual behavior. Moreover, it is unclear how evolutionary history of a population might affect such individual responses. Our …


High School Dropouts, Higher Education Dreams, And Achievement: A Six-Year Study Of A High-Stakes Test In Brazil, Eveline Miranda Dec 2022

High School Dropouts, Higher Education Dreams, And Achievement: A Six-Year Study Of A High-Stakes Test In Brazil, Eveline Miranda

Theses and Dissertations

Rumberger (2020) observed that "dropping out of school has economic and social consequences both for dropouts themselves and for the country as a whole" (p. 151). Every year, many Brazilians drop out of school due to work, early pregnancies, marriage, drug consumption, crime, etc. Dropping out of school can occur due to learning challenges, poor attendance, discipline problems, or a lack of access to high school institutions. Dropouts can experience depression and anxiety and are more likely to attempt suicide. The present dissertation includes two different papers about dropouts. The first paper uses fixed effect regression to show the main …


Structural Reasoning With Rational Expressions, Dana Steinhorst Dec 2022

Structural Reasoning With Rational Expressions, Dana Steinhorst

Theses and Dissertations

Many students struggle to make sense of algebraic expressions in math. This lack of understanding results in students making symbolic manipulation errors, hindering their procedural fluency. Researchers believe these errors are linked to students' lack of structural reasoning. While research has shown that students rarely engage in expert structural reasoning, little is known about how students actually reason structurally. In this study, I interviewed six high school calculus students to study the way they identified, matched, and evaluated structures as they solved problems involving rational expressions and equations. I analyzed the participant interviews and outlined the matching process they used …


Teaching Social-Emotional Learning To Children With Autism Using Animated Avatar Video Modeling, Emelie Davis Dec 2022

Teaching Social-Emotional Learning To Children With Autism Using Animated Avatar Video Modeling, Emelie Davis

Theses and Dissertations

People with a diagnosis of autism spectrum disorder (ASD) often have difficulties understanding or applying skills related to Social-Emotional Learning (SEL). An individual having a better understanding of SEL concepts is generally associated with more fulfilling connections with others and increased satisfaction in life. Since people with ASD tend to have greater success with learning in structured environments, we created a module to teach these skills using Nearpod. These modules were created with videos of a person embodying a cartoon dog face using Animoji for two reasons; because the animation was meant to appeal to children, and the creation was …


Determination Of A Catalytic Mechanism By Time Resolved Fourier Transform Infrared Spectroscopy And Time Domain Analysis Of Data From Fourier Transform Ion Cyclotron Resonance Mass Spectrometry, Jacob T. Davis Dec 2022

Determination Of A Catalytic Mechanism By Time Resolved Fourier Transform Infrared Spectroscopy And Time Domain Analysis Of Data From Fourier Transform Ion Cyclotron Resonance Mass Spectrometry, Jacob T. Davis

Theses and Dissertations

Heterobimetallic catalysts offer large potential for efficient and selective catalysis of a wide range of reactions. Better understanding of these catalytic mechanisms could yield further improvement in their catalytic abilities. Cp(CO)2Fe-Cu(IPr) (IPr = N,N-bis(2,6-diisopropylphenyl)imidazol-2-ylidene) is a catalyst that has been reported to catalyze arene borylation. The catalytic mechanism of this catalyst that had been previously proposed had the initial step being a metal-metal cleavage. However, computational modeling suggested an alternate mechanism that could be more energetically favorable. Rather than a metal-metal cleavage as the initial step, we proposed a photoactivated carbonyl dissociation. To support this proposition, we performed time resolved …


Zeros Of A Family Of Complex-Valued Harmonic Rational Functions, Alexander Lee Dec 2022

Zeros Of A Family Of Complex-Valued Harmonic Rational Functions, Alexander Lee

Theses and Dissertations

The Fundamental Theorem of Algebra is a useful tool in determining the number of zeros of complex-valued polynomials and rational functions. It does not, however, apply to complex-valued harmonic polynomials and rational functions generally. In this thesis, we determine behaviors of the family of complex-valued harmonic functions $f_{c}(z) = z^{n} + \frac{c}{\overline{z}^{k}} - 1$ that defy intuition for analytic polynomials. We first determine the sum of the orders of zeros by using the harmonic analogue of Rouch\'e's Theorem. We then determine useful geometry of the critical curve and its image in order to count winding numbers by applying the harmonic …


Issues In Melanoma Detection: Semisupervised Deep Learning Algorithm Development Via A Combination Of Human And Artificial Intelligence, Xinyuan Zhang, Ziqian Xie, Yang Xiang, Imran Baig, Mena Kozman, Carly Stender, Luca Giancardo, Cui Tao Dec 2022

Issues In Melanoma Detection: Semisupervised Deep Learning Algorithm Development Via A Combination Of Human And Artificial Intelligence, Xinyuan Zhang, Ziqian Xie, Yang Xiang, Imran Baig, Mena Kozman, Carly Stender, Luca Giancardo, Cui Tao

Faculty, Staff and Student Publications

BACKGROUND: Automatic skin lesion recognition has shown to be effective in increasing access to reliable dermatology evaluation; however, most existing algorithms rely solely on images. Many diagnostic rules, including the 3-point checklist, are not considered by artificial intelligence algorithms, which comprise human knowledge and reflect the diagnosis process of human experts.

OBJECTIVE: In this paper, we aimed to develop a semisupervised model that can not only integrate the dermoscopic features and scoring rule from the 3-point checklist but also automate the feature-annotation process.

METHODS: We first trained the semisupervised model on a small, annotated data set with disease and dermoscopic …


Board Of Directors Meeting Minutes (December 12, 2022), Dmacc Dec 2022

Board Of Directors Meeting Minutes (December 12, 2022), Dmacc

Board of Directors Meeting Minutes

This file contains the minutes from the Des Moines Area Community College Board meeting held on December 12, 2022.


Explaining Suharto's Rise And Fall: International And Domestic Variables, Julia Batanghari Dec 2022

Explaining Suharto's Rise And Fall: International And Domestic Variables, Julia Batanghari

Undergraduate Honors Theses

For three decades (1968-1998), Indonesia was led by President Suharto, whose authoritarian military regime is remembered for its corruption and brutality. This paper offers an analysis of Suharto’s rule through the lens of two events: his 1965 purge of local ‘communists’ and the riots of May 1998. Drawing comparisons between the two, I delve into systemic causes by considering the influence of domestic and international variables. Exploring links between intergroup accommodation and democracy reveals that Suharto’s lack of ethnic, socioeconomic, and religious inclusivity paved the way not only for the anti-Chinese sentiment which pervaded Indonesian society during his presidency, but …


A Preliminary Assessment Of Compassion Fatigue In Chimpanzee Caregivers, Mary Lee A. Jensvold Dec 2022

A Preliminary Assessment Of Compassion Fatigue In Chimpanzee Caregivers, Mary Lee A. Jensvold

Anthropology and Museum Studies Faculty Scholarship

Compassion fatigue is defined as “traumatization of helpers through their efforts at helping others”. It has negative effects on clinicians including reduced satisfaction with work, fatigue, irritability, dread of going to work, and lack of joy in life. It is correlated with patients’ decreased satisfaction with care. Compassion fatigue occurs in a variety of helping professions including educators, social workers, mental health clinicians, and it also appears in nonhuman animal care workers. This study surveyed caregivers of chimpanzees using the ProQOL-V to assess the prevalence of compassion fatigue among this group. Compassion satisfaction is higher than many other types of …


Efficacy And Safety Of Fecal Microbiota Transplantation In Treatment Of Clostridioides Difficile Infection Among Pediatric Patients: A Systematic Review And Meta-Analysis, Kyaw Min Tun, Mark Hsu, Kavita Batra, Chun-Han Lo, Tooba Laeeq, Tahne Vongsavath, Salman Mohammed, Annie S. Hong Md Dec 2022

Efficacy And Safety Of Fecal Microbiota Transplantation In Treatment Of Clostridioides Difficile Infection Among Pediatric Patients: A Systematic Review And Meta-Analysis, Kyaw Min Tun, Mark Hsu, Kavita Batra, Chun-Han Lo, Tooba Laeeq, Tahne Vongsavath, Salman Mohammed, Annie S. Hong Md

Department of Internal Medicine Faculty Research

Background and Aims: Cases of Clostridioides difficile infection have been rising among the pediatric and adolescent population. Fecal microbiota transplantation (FMT) has emerged as an alternative therapy for recurrent C. difficile infection. We aim to perform the first systematic review and meta-analysis investigating the safety and efficacy of fecal microbiota transplantation for C. difficile infection in children and adolescents. Methods: A literature search was performed using variations of the keywords “pediatrics”, “C. difficile infection”, and “fecal microbiota transplantation” in PubMed, EMBASE, CINAHL, Cochrane, and Google Scholar from inception to 30 June 2022. The resulting 575 articles were independently screened by …


Bob Reich Oral History Interview, Bob Reich, Mathew Lin Dec 2022

Bob Reich Oral History Interview, Bob Reich, Mathew Lin

Raymond College

No abstract provided.


Teaching Autistic Children To Independently Wash Their Hands: A Systematic Review Of Behavioral Techniques, Alexis Vazquez Dec 2022

Teaching Autistic Children To Independently Wash Their Hands: A Systematic Review Of Behavioral Techniques, Alexis Vazquez

Seton Hall University Dissertations and Theses (ETDs)

With COVID 19 having changed the world’s perception on daily hygiene, people are aiming to improve the rate and efficacy of their hand washing. Autistic children, having a history of challenges with daily living skills, may need support when learning the skill of hand washing. The current review discusses interventions used to teach autistic children effective hand washing and investigates if those interventions meet criteria to be considered an evidence-based practice. Six studies met the inclusion criteria and data were synthesized narratively. Given the importance of hand washing in society, more research is necessary to achieve optimal outcomes. The review …


The Relationship Between Parcc Ela 8 Performance And Performance On Ap Exams, Michael G. Portas Dec 2022

The Relationship Between Parcc Ela 8 Performance And Performance On Ap Exams, Michael G. Portas

Seton Hall University Dissertations and Theses (ETDs)

This quantitative study is primarily intended to examine whether district level performance results from Grade 8 ELA state assessments can help to predict future passing rates on AP exams. The participants for the study are all 218 K-12 school districts in New Jersey, all of which generated results across score levels and passing rates for PARCC testing in the academic years ending in 2015-2017. District level data were also examined for possible predictive validity on AP passing rates in 2019-2021 across categories including demographics, college entrance exams taken in high school, and participation rates in AP/IB coursework and exams, most …


Bis-Indolyl Compounds And The Induction Of Apoptosis In T98g Glioblastoma Multiforme Cells, Margot C. Brown Dec 2022

Bis-Indolyl Compounds And The Induction Of Apoptosis In T98g Glioblastoma Multiforme Cells, Margot C. Brown

Seton Hall University Dissertations and Theses (ETDs)

1,1-bis(3’idolyl)-1(aryl)methane compounds (BIM compounds) have been shown to have anti-cancer properties in colon cancer, bladder cancer, and leukemia cells. The purpose of this work was to determine if BIM compounds could be an effective treatment of glioblastoma multiforme. Sulforhodamine B (SRB) assays showed that 20µM of the BIM compounds could inhibit cellular proliferation of the T98G glioblastoma multiforme cell line over 72 hours. Then immunoblotting was used to analyze the molecular pathway induced by BIM compounds. An increase in the expression of both BAX and cleaved caspase 3 suggest BIM compounds activate programmed cell death, or apoptosis in glioblastoma cells. …


Understanding The Experiences Of African American Caregivers Of Loved Ones With Dementia, Paula R. Madison Dec 2022

Understanding The Experiences Of African American Caregivers Of Loved Ones With Dementia, Paula R. Madison

Seton Hall University Dissertations and Theses (ETDs)

Background: Dementia is a public health problem that is estimated to triple by 2050.Globally, dementia is the seventh leading cause of death among all diseases and one of the major causes of disability and dependency among older people. The direct medical costs and indirect social and economic costs of dementia are burdensome to society, and by 2030 it is projected to cost more than $2.8 TRILLION dollars worldwide. African Americans are two to four times more likely to be diagnosed with dementia than White Americans; and more likely to rely on informal care from family and friends. African …


A Path To Translation: How 3d Patient Tumor Avatars Enable Next Generation Precision Oncology, Shree Bose, Margarida Barroso, Milan G Chheda, Hans Clevers, Elena Elez, Salma Kaochar, Scott E Kopetz, Xiao-Nan Li, Funda Meric-Bernstam, Clifford A Meyer, Haiwei Mou, Kristen M Naegle, Martin F Pera, Zinaida Perova, Katerina A Politi, Benjamin J Raphael, Paul Robson, Rosalie C Sears, Josep Tabernero, David A Tuveson, Alana L Welm, Bryan E Welm, Christopher D Willey, Konstantin Salnikow, Jeffrey H Chuang, Xiling Shen Dec 2022

A Path To Translation: How 3d Patient Tumor Avatars Enable Next Generation Precision Oncology, Shree Bose, Margarida Barroso, Milan G Chheda, Hans Clevers, Elena Elez, Salma Kaochar, Scott E Kopetz, Xiao-Nan Li, Funda Meric-Bernstam, Clifford A Meyer, Haiwei Mou, Kristen M Naegle, Martin F Pera, Zinaida Perova, Katerina A Politi, Benjamin J Raphael, Paul Robson, Rosalie C Sears, Josep Tabernero, David A Tuveson, Alana L Welm, Bryan E Welm, Christopher D Willey, Konstantin Salnikow, Jeffrey H Chuang, Xiling Shen

Faculty, Staff and Students Publications

3D patient tumor avatars (3D-PTAs) hold promise for next-generation precision medicine. Here, we describe the benefits and challenges of 3D-PTA technologies and necessary future steps to realize their potential for clinical decision making. 3D-PTAs require standardization criteria and prospective trials to establish clinical benefits. Innovative trial designs that combine omics and 3D-PTA readouts may lead to more accurate clinical predictors, and an integrated platform that combines diagnostic and therapeutic development will accelerate new treatments for patients with refractory disease.


Single-Shot, Ultrafast, Multi-Frame X-Ray Imaging Of Defect-Bearing Ablator Materials In Extreme Conditions, Daniel S. Hodge Dec 2022

Single-Shot, Ultrafast, Multi-Frame X-Ray Imaging Of Defect-Bearing Ablator Materials In Extreme Conditions, Daniel S. Hodge

Theses and Dissertations

Characterization of the dynamic behavior of defect-bearing ablator materials subjected to extreme conditions is essential in advancing fusion energy as an reliable and abundant energy source. By understanding how materials evolve spatially and temporally we can minimize hydrodynamic instabilities, which are major contributing factors to energy yield degradation in inertial confinement fusion (ICF) experiments. In this thesis we demonstrate the capabilities of an ultrafast x-ray imaging (UXI) detector, the Icarus V2, where we capture multiple frames of single void-bearing sample compressed by a high-intensity laser shockwave. Using the Matter in Extreme Conditions (MEC) instrument at the Linac Coherent Light Source …