Digital Commons Network^™

A Cell Culture Model To Study Tobacco Associated Oral Cancer Progression And Treatment Resistance, Amanda Busch

Theses & Dissertations

Head and Neck Squamous cell carcinoma is the 6^th most common cancer in the world. Risk factors for HNSCC include alcohol and tobacco consumption, infection with Human Papilloma Virus, and exposure to environmental toxins. Unlike many other cancers, the incidence of HNSCC is growing, yet the treatment options and outcomes have not been significantly improved for decades. An increased understanding of the molecular mechanisms of these cancers is needed for improvement in early diagnosis, enhanced treatment effectiveness, and cancer prevention. 4-nitroquinoline 1-oxide (4NQO) is a well-tested, tobacco mimicking, carcinogen. 4NQO produces similar histological and chemical changes found in human …

Teaching Children With Autism Spectrum Disorder Self-Protection Skills In Response To Bullying Situations, Maya J. Fallon

Theses & Dissertations

Children diagnosed with autism spectrum disorder (ASD) are at high risk of being bullied but research on teaching children with ASD self-protection skills for bullying situations is scant. We assessed the generality of teaching procedures used in Stannis et al. (2019) to teach adults self-protection skills with autistic children. We taught five children self-protection skills for two types of bullying (threats and unkind remarks) in a one-on-one format. In addition, we taught children a self-protection skill for repeated bullying occurrences. We first evaluated behavioral skills training to teach children to report threats of physical or material harm, provide a disapproving …

Narrative Review: Food Image Use For Machine Learnings’ Function In Dietary Assessment And Real Time Nutrition Feedback And Education, Jason Fee

Masters Theses, 2020-current

Technology has played a key role in advancing the health and agriculture sectors to improve obesity rates, diseasecontrol, food waste, and overall health disparities. However, these health and lifestyle determinants continue to plague theUnited States population. While new technologies have been and are currently being developed to address these concerns, they may not be practical for the general population. Utilizing machine learning advancement in food recognition using smartphone technology may be a means to improve the dietary component of nutrition assessments while providing valuable nutrition feedback. This narrative review was conducted to assess the current state of the literature on …

New York Set High Sights On A Progressive Retail Weed Industry. But The State Now Stands To Fall Short., Trina Mannino

Capstones

Almost a year-and-a-half after New York legalized recreational marijuana, state officials and other industry insiders praise what they view as the country's most socially equitable cannabis industry. But as New York prepares to launch its legal retail dispensary program, rollout details remain murky. The state also faces challenges with the legal industry’s most significant obstacle: illicit sales. If the state doesn’t deliver an equitable and robust market, New York risks winding up with a sputtering legal industry that could cause harm to the very people and communities it intends to lift up.

Link: https://trinamannino9.wixsite.com/mannino-mckinney

The Experiences Of Nyc's Social Equity Cannabis Initiative, Jimmie J. Mckinney Ii

Capstones

This capstone is a photo essay on the experiences of NYS's dispensary licenses applicants as they make their bid to be one of the first legal dispensaries in the state. The priority was to give those who've been arrested for cannabis a chance to benefit from their conviction. Photography, print, and videography were incorporated in this project.

Here is a link to my capstone website: https://readymag.com/u2050520461/mckinneycapstone/

Grip Characterization Of Protective Gloves, Doris Burns

Theses & Dissertations

In 2014, ASTM International (ASTM), one of the world's largest international standards developing organizations, published a new test method on glove grip performance. This method was adopted by the National Fire Protection Association (NFPA) in some of their specification standards. The method utilized hand torque instead of the pull method previously used by the NFPA to determine the Percent Bare Hand Control Value (%BHCV). The %BHCV, compares torque results of a gloved hand versus a bare hand. In developing this new test method, only four males and one female participated; therefore, it is unclear if statistical significance was attained. In …

The Experiences Of Nyc's Social Equity Cannabis Initiative, Jimmie J. Mckinney Ii

Capstones

This capstone is a photo essay documenting the experiences of a few recreational cannabis dispensary applicants. These stores will be some of the first legal dispensaries in NYS and owned by those once arrested for cannabis-- and their families. Photography, text, and videography are incorporated in the project.

Here is a link to my capstone website: https://readymag.com/u2050520461/4094571/

Performatives In Argentine Supreme Court Dissents: A Jurilinguistic Proposal For Civilian Change Based On The American Common Law, Mariano Vitetta

Journal of Civil Law Studies

This article explores a linguistic defect in how Argentine Supreme Court dissents are written. The reader of these dissents has a hard time distinguishing between a majority opinion and a dissenting opinion, because dissents are written “as if” they were deciding the case. The confusion results from the use of performative language in dissents when adherence to reality and a plain-language approach require modal verbs reflecting the language of suggestion. This is actually the way dissents are expressed in the United States, the jurisdiction from which the Argentine Supreme Court copied its constitutional design. To make the case against the …

Decreasing Hospital Acquired Pneumonia In Adult Patients By Patient Care Technicians: Education With A Focus On Oral Care And Tooth Brushing, Amanda Nicole Lee

Master's Projects and Capstones

Hospital acquired pneumonia’s (HAPs) are unfortunate and preventable events quality improvement efforts should focus on. At a Northern California Hospital, there was an unmet HAP rate goal of 2.3 (20 out of 8795 patients) against a target goal of 2. This increase in HAP rates, both non-ventilated and ventilated was a call to action to reduce HAP to the target goal. The quality improvement project specifically aimed to reduce HAP rates on medical-surgical units through an ultra-brief refresher on the hospital validated and endorsed ROUTE bundle. The education focused on oral care completed by the patient care technicians (PCT’s). The …

Esp In Nursing: Building Communicative Competence For Internationally-Educated Nurses, Sami Vuong

Master's Projects and Capstones

The nursing shortage in the United States has been an ongoing issue due to nursing burnout and retirement. Together with the COVID-19 pandemic, it has further exhausted the healthcare system’s resources and healthcare providers. In order to sustain the healthcare system in society, a large number of internationally educated nurses (IENs) have been transferred to work in the United States. As a result of different nursing practices, cultures, and communication styles, many IENs experience language and cultural barriers at work. Difficulty in communication influences the quality of patient care provided, which can lead to negative health outcomes for patients and …

United States Pharmacopeia (Usp) <800> Standards: Increasing Compliance Of Safe Handling And Proper Administration Of Usp General Chapter <800> Drugs, Katelyn N. Sinclair

Master's Projects and Capstones

Problem: United States Pharmacopeia (USP) developed a set of standards to minimize exposure risks to patients, healthcare workers, and the environment when preparing, handling, and administering hazardous drugs (HDs) known as USP <800> HDs. The guidelines became effective December 1, 2019, but additional information is needed to ensure healthcare personnel are complying with the standards.

Context: Two medical surgical units from Hospital A were included in this project. Currently mandatory online modules about USP <800> standards are provided annually to every healthcare worker, but it is unknown if the policies and procedures are being followed appropriately.

Interventions: Active and passive observations as …

In Vivo Characterization Of Glutamine Metabolism Identifies Therapeutic Targets In Clear Cell Renal Cell Carcinoma, Akash K Kaushik, Amy Tarangelo, Lindsey K Boroughs, Mukundan Ragavan, Yuanyuan Zhang, Cheng-Yang Wu, Xiangyi Li, Kristen Ahumada, Jui-Chung Chiang, Vanina T Tcheuyap, Faeze Saatchi, Quyen N Do, Cissy Yong, Tracy Rosales, Christina Stevens, Aparna D Rao, Brandon Faubert, Panayotis Pachnis, Lauren G Zacharias, Hieu Vu, Feng Cai, Thomas P Mathews, Giannicola Genovese, Barbara S Slusher, Payal Kapur, Xiankai Sun, Matthew Merritt, James Brugarolas, Ralph J Deberardinis

Faculty, Staff and Student Publications

Targeting metabolic vulnerabilities has been proposed as a therapeutic strategy in renal cell carcinoma (RCC). Here, we analyzed the metabolism of patient-derived xenografts (tumorgrafts) from diverse subtypes of RCC. Tumorgrafts from VHL-mutant clear cell RCC (ccRCC) retained metabolic features of human ccRCC and engaged in oxidative and reductive glutamine metabolism. Genetic silencing of isocitrate dehydrogenase-1 or isocitrate dehydrogenase-2 impaired reductive labeling of tricarboxylic acid (TCA) cycle intermediates in vivo and suppressed growth of tumors generated from tumorgraft-derived cells. Glutaminase inhibition reduced the contribution of glutamine to the TCA cycle and resulted in modest suppression of tumorgraft growth. Infusions with …

Processing And Cryopreservation Of Human Ureter Tissues For Single-Cell And Spatial Transcriptomics Assays, Emily E Fink, Surbhi Sona, Byron H Lee, Angela H Ting

Faculty, Staff and Student Publications

Characterizing the cellular heterogeneity of human ureter tissues using single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics provides a detailed atlas of cell types, signaling networks, and potential cell-cell cross talk underlying developmental and regenerative pathways. We describe an optimized protocol for generating, cryopreserving, and thawing single-cell suspensions from ureter tissues isolated post-cystectomy for scRNA-seq. In addition, we describe an optimized protocol for cryopreserving human ureter tissues for 10x Genomics Visium spatial gene expression platform. For complete details on the use and execution of this protocol, please refer to Fink et al. (2022).

Sunsetting Excessive Chest X-Rays In An Intensive Care Unit: A Quality Improvement Project, Cassandra Sweet

Doctors of Nursing Practice (DNP) Final Projects, 2020-current

In the cardiovascular service line at an academic medical center in the southeastern United States, obtaining daily chest x-rays still occurred despite evidence that it is unnecessary and possibly even harmful. This quality improvement project was implemented in a 24-bed Cardiovascular Intensive Care Unit and 20-bed acute care unit, together considered to be the cardiac service line. Using the implementation framework of the Model for Improvement and Plan/Do/Study/Act, a guideline that outlines appropriate times to obtain a chest x-ray based on the American College of Radiology’s appropriateness criteria was created. Daily chest x-rays were eliminated and replaced with an on-demand …

Medication Reconciliation Policy Analysis: A Collaborative Project With The Principal Hospital In Cayman Islands Health System, Bethany Landes

Doctors of Nursing Practice (DNP) Final Projects, 2020-current

Medication errors, readmissions, and chronic disease management complications are modifiable healthcare problems. Standardized Medication Reconciliation (Med Rec) policies can impact healthcare organizations' patient safety by reducing these medication errors, decreasing readmission rates, enhance the management of chronic disease while also offering fiscal stewardship for healthcare systems. Medication management standardized policies are an expectation of systems aiming to gain Joint Commission (JC) accreditation. The principal hospital of the Cayman Islands does not have a medication reconciliation policy. Using The Eightfold Path to More Effective Problem Solving, multiple policy options that offer evidence-based recommendations were reviewed for consideration of a standardized Med …

Developing Influential Nurse Leaders: Utilizing Strengths And Styles Assessments To Create Individualized, Intentional Coaching, Linda Shepherd

Doctors of Nursing Practice (DNP) Final Projects, 2020-current

Abstract

Background: A north-central Virginia university and a hospital in the British West Indies (BWI) entered a collaborative agreement in 2020. Growing competitive environments heightened awareness and urgency in creating expansively competent, influential nurse leaders in the BWI. Without formalized data to quantify or validate nurse manager strengths, leadership style, or competencies, an assessment of these items and an evidence-based coaching intervention were performed.

Methods: The population for this evidence-based (EB) practice project was 20 inpatient nurse leaders. The Multifactor Leadership Questionnaire (MLQ) and the Clifton Strength Finders Assessment (CSF) for Managers were deployed as pre-intervention assessment tools. …

Queen Academy, Hantian Zhnag

Master's Theses

As an upmarket novel exploring immigration and racial dynamics, Queen Academy lies at the intersection of Kathryn Ma’s The Chinese Groove, Timothy Wang’s Slant, and Toni Morrison’s The Bluest Eye in style and subject. The protagonist Kang comes to the US from China to study statistics, but finds himself becoming a “potato queen”—an Asian gay man interested in dating white men only—and locked in self-loathing. It will take a heartbreak and treading the line of illegality to see himself again. Overall, by engaging with themes of immigration, belonging, and racialized desire, the novel takes the stance that the …

Relationships Among Age, Relative Telomere Length, And Dna Methylation In Pteropus Bats, Erika E. Forest

Masters Theses

Bats are the longest-lived mammalian order relative to body mass, but questions remain about relationships among mechanisms related to aging. Relative telomere length (rTL) decreases with age in most mammals, but the relationship between age and rTL is highly variable among the few bat taxa studied to date. More recently, DNA methylation (DNAm), a type of epigenetic regulation in which methyl groups are added to cytosine-phosphate-guanine (CpG) sites across the genome, has been shown to be highly predictive of age in many species of bats. We examine the relationships among age, rTL, and DNAm in Pteropus pumilus and P. hypomelanus …

Writer Identity Using Stylometry And Machine Learning, Abdulla Alshuweihi, Sultan Alblooshi

Theses

This particular study will be based on linguistics and stylometric use to find or identify the legitimate authors of the text. For this purpose, the study is expected to use the machine learning approach or framework that consists of various features to sort out and find the style of writing belonging to the right author. The machine learning approach is accompanied by the support of SAS (Statistical Analysis System).

SAS covers the algorithms problems required for better accurate functioning of machine learning approach experiments. In this learning framework, the experiments use a large amount of data to sort and filter …

Delineating Differences In How Us High Schools Are Racialized, Dara Shifrer, C. J. Appleton

Sociology Faculty Publications and Presentations

Schools’ overt or explicit practices are a dominant lens through which education researchers and policymakers attempt to understand how schools are racially inequitable. Yet, Lewis and Diamond argue that contemporary racial inequalities are largely sustained through implicit factors, like institutional practices and structural inequalities. Ray’s framework on racialized organizations similarly outlines how our racialized sociopolitical structure becomes embedded in organizations, legitimating and perpetuating the racialized hierarchy. We apply illustrative cluster analysis techniques to rich data on schools, teachers, and students from the nationally representative High School Longitudinal Study of 2009 to find that structural inequities (e.g., student body, sector, average …

A Systematic Approach To Provide Feedback To Presenters At Virtual And Face-To-Face Professional Meetings, S Beth Bierer, Anna Cianciolo, Heeyoung Han, Janice Hanson

2020-Current year OA Pubs

INTRODUCTION: To promote their personal and professional growth, medical educators need practical, actionable feedback on their scholarship, as well as guidance for documenting their scholarship in educator portfolios. We offer a framework and resources to provide formative and summative feedback to faculty, administrators, and/or learners delivering an oral presentation at a face-to-face or virtual health professions education meeting.

METHODS: In 2014, the leadership of the Central Group on Educational Affairs (CGEA) meeting planning committee developed and piloted a process to provide individuals with formative and summative feedback on their oral CGEA research presentations at face-to-face meetings and create a transparent …

Acetylacetone Oxidation At Room Temperature: A Multiplexed Photoionization Mass Spectrometric Investigation, Study Of The Russell Intermediates In Gas Phase Reactions, And The Investigation Of Oxidation Reaction Products Of Ethanol At Room Temperature, Sara Gallarati

Master's Theses

This thesis presents the combustion study of acetyl acetone using synchrotron radiation coupled with multiplexed photoionization mass spectrometry at 298 K. The experiments were performed at the Chemical Dynamics Beamline 9.0.2 at the Advanced Light Source of the Lawrence Berkeley National Laboratory. The reaction of acetyl acetone with chlorine (Cl) radicals was analyzed based on their photoionization spectra and reaction kinetic profiles.

Additionally, a study of the Russell intermediate has been performed. Previous to experimentation at the Advanced Light Source, computational analysis has been investigated to evaluate compounds that could possibly lead to the formation of a stable species. The …

Motives For (In)Effective Giving: Comparing Rural And Urban Groups In South Africa., Luvuyo Bulelani Magwaza

Master's Theses

Different cultures have their own set of norms and values that not only shape people’s motives but also influences their decision making. What may be viewed as logical and ethical in one culture, may be seen as illogical or unethical in another. One area that is consistently affected by cross-cultural differences in motives is charitable giving. Recently, there has been an increase in interest around effective altruism— a social movement and philosophy that argues, people should give to charities that do the most good. Prior research that has found that people do not give based on efficiency; instead, people give …

Virginia, Zachary H. Barrett

Oil and Gas, Natural Resources, and Energy Journal

No abstract provided.

New York, Delainey Banks

Oil and Gas, Natural Resources, and Energy Journal

No abstract provided.

Colorado, Diana S. Prulhiere, David R. Little

Oil and Gas, Natural Resources, and Energy Journal

No abstract provided.

Lessons From History: The Remarkable Leadership Of Eleanor Roosevelt And Why It Matters Today (Part 1), Emilio F. Iodice

The Journal of Values-Based Leadership

Few people had a greater impact on their generation than Eleanor Roosevelt. She was what she professed to be: a person not afraid of criticism, willing to sacrifice and take responsibility and to lead others by her example. Her life was filled with moments of courage, wisdom, compassion, empathy, and amazing emotional intelligence. The following is Part I of an overview of her life, her leadership secrets, and how she dealt with enormous challenges as a person ― a human being and a woman who grew up in an age of prejudice and discrimination.

Timeless Lessons About Leadership From The Midrash, Hershey H. Friedman

The Journal of Values-Based Leadership

This paper examines two ancient Midrashim and shows that many important messages about leadership are embedded in them. The first Midrash describes the critical personality trait Moses possessed that made him uniquely suitable to be a leader of the Israelites — compassion. The second Midrash appears heretical since it has Moses correcting God. Indeed, God even openly admits, "You have taught me something." The primary lessons are that leaders must be compassionate, humble, willing to listen to advice, eager to make changes when necessary, and admit to mistakes.

Kailua Canoe Club: A Values-Based Holistic Approach To Leadership, Peggy Peattie, Cristina Padilla, Maile Villablanca

The Journal of Values-Based Leadership

This qualitative case study of Kailua Canoe Club (KCC) on the island of O’ahu investigated the nature of leadership in a Hawaiian outrigger paddling community. Conversations with paddlers, coaches, and board members revealed a values-based holistic approach to leadership (Best, 2011). Those values were scribed into the club’s mission statement 50 years ago with the intention of establishing KCC as a space to connect with kupuna (respected elder) wisdom, develop paddling skills, and to honor the canoe, the ocean, and each other. A component of leadership kuleana (responsibility) is constant reflection on those values, and the mentoring of the younger …

Positional Authority And Influence In Servant Leadership: A Conceptual Model, Kevin J. Hurt, Elliott Long

The Journal of Values-Based Leadership

This conceptual research paper reviews how positional authority affects the servant leadership-organizational performance relationship and provides insight on how servant leadership can be implemented and effective in the absence of positional authority, i.e. through the cultivation and leveraging of influence. A review of servant leadership literature is used to propose that servant leadership is positively associated with increased organizational performance. Through the lens of upper echelon theory as well as research on the performance of organizations whose executive team practices servant leadership, we develop a model and make a case that positional authority is an important moderator of the relationship …