Digital Commons Network^™

The Cultic Lifecycle: A Thematic Analysis Of Fulfillment And Fear In Cult Membership, Shaelen Grant

Student Theses

Prior research on susceptibility to cult recruitment has focused predominately on psychopathological risk factors, such as a prior personality disorder diagnosis and psychiatric and addictive disorders (Feldman & Johnson, 1995; Rousselet et al., 2017). While such studies contribute valuable information, they also inadvertently pathologize cult members. Furthermore, this focus has led to the overlooking of a more crucial question: what basic human desires does cult membership fulfill that cult leaders and recruiters exploit, to recruit and keep members in cults? To address this dearth, research team members interviewed 52 former cult members (N=52) from a variety of groups (e.g., Christian-based, …

Identification Of A Novel Large Multigene Deletion And A Frameshift Indel In Pde6b As The Underlying Cause Of Early-Onset Recessive Rod-Cone Degeneration, Riccardo Sangermano, Pooja Biswas, Lori S Sullivan, Emily M Place, Shyamanga Borooah, Juerg Straubhaar, Eric A Pierce, Stephen P Daiger, Kinga M Bujakowska, Radha Ayaggari

Faculty, Staff and Student Publications

A family, with two affected identical twins with early-onset recessive inherited retinal degeneration, was analyzed to determine the underlying genetic cause of pathology. Exome sequencing revealed a rare and previously reported causative variant (c.1923_1969delinsTCTGGG; p.Asn643Glyfs*29) in the

Sex-Related Differences In Violence Exposure, Neural Reactivity To Threat, And Mental Health, Heather E Dark, Nathaniel G Harnett, Danielle R Hurst, Muriah D Wheelock, Kimberly H Wood, Adam M Goodman, Sylvie Mrug, Marc N Elliott, Susan Tortolero Emery, Mark A Schuster, David C Knight

Faculty, Staff and Student Publications

The prefrontal cortex (PFC), hippocampus, and amygdala play an important role in emotional health. However, adverse life events (e.g., violence exposure) affect the function of these brain regions, which may lead to disorders such as depression and anxiety. Depression and anxiety disproportionately affect women compared to men, and this disparity may reflect sex differences in the neural processes that underlie emotion expression and regulation. The present study investigated sex differences in the relationship between violence exposure and the neural processes that underlie emotion regulation. In the present study, 200 participants completed a Pavlovian fear conditioning procedure in which cued and …

Understanding And Targeting The Immunosuppressive Tumor Microenvironment, Li Cai, Li Cai

Dissertations and Theses (Open Access)

Immune checkpoint inhibitors (ICIs), such as anti-PD1/PD-L1 and anti-CTLA-4, have shown impressive antitumor efficacy by improving the activity of T cells. While these inhibitors work in many patients with various cancer types, they have minimal or no effect in many more patients. Mounting evidence indicates that, besides current known immune checkpoints, other immunosuppressive components in the tumor microenvironment (TME) need to be targeted to elicit the full immune responses.

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of immunosuppressive myeloid cells that are involved in cancer progression and therapeutic resistance. In this work, we demonstrated the essential role of MDSCs …

Quantifying The Magnitude Of To Tal Dose Deviation Caused By Various Sources Of Error Among Iroc Phantom Irradiation Results, Sharbacha S. Edward

Dissertations and Theses (Open Access)

The Imaging and Radiation Oncology Core (IROC) phantoms are used as an end-to-end test of an institution’s radiotherapy processes, and for clinical trial credentialing. Phantoms are treated like patients, and evaluation of the doses received by the thermoluminescent dosimeters (TLDs) inside the phantom, reflects the accuracy with which an institution can image, plan and irradiate a phantom or patient. Recent phantom results show that among the hundreds of various IROC phantoms irradiated annually, 8-17% of institutions fail this test. The purpose of this work was to investigate the various types of errors that may occur during the treatment process and …

Bayesian Adaptive Clinical Trial Design, Mengyi Lu

Dissertations and Theses (Open Access)

The landscape of drug development in oncology has changed from conventional chemotherapies to molecular targeted therapies and immunotherapies, which provide innovative therapeutic modalities for treating cancers. These novel therapeutic agents work through mechanisms that fundamentally differ from standard chemotherapeutic agents, making the conventional trial design paradigm inefficient and dysfunctional. Specifically, the focus of dose-finding trials has shifted from finding the maximum tolerated dose (MTD) to the optimal biological dose (OBD), defined as the dose that optimizes the risk–benefit tradeoff. How to accurately identify the OBD and its dosing schedule is of great importance to maximize efficacy and safety of targeted …

Individual Differences In Lpp Amplitude And Theta Power Predict Cue-Induced Eating During A Cued Food Delivery Task, Kyla Gibney

Dissertations and Theses (Open Access)

Due to individual differences in the brain’s reward system, some individuals are more vulnerable than others to maladaptive, reward-seeking behaviors, such as substance use or compulsive eating. A body of research has demonstrated that individuals who attribute higher levels of incentive salience to reward-associated cues than to pleasant images (termed “C>P group” throughout) are more vulnerable to compulsive eating than those who attribute higher incentive salience to pleasant images than reward- associated cues (P>C group). Meanwhile, a separate body of research has demonstrated that cognitive control also regulates eating by enabling top-down attentional control. This dissertation aims to …

Risk-Factor Induced Changes In The Breast Microenvironment Facilitate Inflammatory Breast Cancer Progression And Lymphovascular Invasion, Wintana Balema, Wintana Balema

Dissertations and Theses (Open Access)

Inflammatory breast cancer (IBC) is a rapidly progressing, rare and highly lethal form of breast cancer. IBC is a clinical diagnosis, requiring >1/3 involvement on the affected breast and/or skin by erythema, and disease onset of < 6 months. The clinical symptoms of IBC vary in severity and presentation, these include redness, warmth, skin thickening and bruised or pink/purple discoloration appearance and skin changes such as peau d’orange. These skin symptoms are not attributed to inflammation, rather IBC is characterized by florid lymphovascular tumor emboli clogging dermal lymphatics. This leads to “classic” symptoms of breast swelling and skin edema or discoloration. To date, unique genomic drivers which differentiate IBC from non-IBC invasive breast cancers have not been identified highlighting a role for the microenvironment. Several epidemiological studies have unveiled subtype-specific risk factors associated with IBC that are known to alter the microenvironment. Obesity is an established risk factor for all subtypes of IBC. Never-breastfeeding increases risk for developing the most aggressive, triple-negative IBC. Further, never breastfeeding is associated with later clinical stage and worse outcomes. We worked to model these overlapping risk factors to understand microenvironment changes that may lead to the lymphatic change’s indicative of IBC.

First, we investigated the association of a “classic” triad of clinical IBC signs with overall survival among patients to demonstrate the most overt clinical findings of lymphatic involvement were impacting prognosis. We evaluated a triad of IBC signs, including swollen involved breast, nipple change, and diffuse skin change, using breast medical photographs from patients enrolled on a prospective IBC registry. We reported that the …

Ankyrin Dependent Mitochondrial Function And Bioenergetics In The Heart, Janani Subramaniam, Janani Subramaniam

Dissertations and Theses (Open Access)

ANK2 mutations in patients are associated with numerous arrhythmias, cardiomyopathies, and other heart defects. In the heart, AnkB, the protein encoded by ANK2, clusters relevant ion channels and cell adhesion molecules in several important domains; however, its role at Mitochondria Associated ER/SR Membranes (MAMs) has yet to be investigated. MAMs are crucial to mitochondrial function and metabolism and are signaling hubs implicated in various cardiac pathologies. Among several functions, these sites mediate the direct transfer of calcium from the ER/SR to the mitochondria to modulate ATP synthesis. Given that mitochondrial function and energy production are paramount to cardiovascular heath, …

Analysis Of The Issue Of New Mexico Black Male Educators’ Underrepresentation In Education Within New Mexico, Robert Sims Jr.

Dissertations

Increasing the educational profession's racial, gender, and ethnic diversification ensures the intentionality and equity of having more Black male educators serve as role models in U.S. schools. There is a need to understand better the journey and experiences of Black male educators, wherefore greater grassroots recruitment and retention efforts can be implemented to support Black men and young Black males who may aspire to become educators. Research that captures the experiences of Black male youth and educators as they navigate teaching and learning in predominately White educational systems may promote lines of inquiry for further research and intentional dialogue for …

Irreducible Representations From Group Actions On Trees, Charlie Liou

Master's Theses

We study the representations of the symmetric group $S_n$ found by acting on

labeled graphs and trees with $n$ vertices. Our main results provide

combinatorial interpretations that give the number of times the irreducible

representations associated with the integer partitions $(n)$ and $(1^n)$ appear

in the representations. We describe a new sign

reversing involution with fixed points that provide a combinatorial

interpretation for the number of times the irreducible associated with the

integer partition $(n-1, 1)$ appears in the representations.

The Importance Of Hand Motions For Communication And Interaction In Virtual Reality, Alex Adkins

All Dissertations

Virtual reality (VR) is a growing method of communication and play. Recent advances have enabled hand-tracking technologies for consumer VR headsets, allowing virtual hands to mimic a user's real hand movements in real-time. A growing number of users now utilize hand-tracking when using VR to manipulate objects or to create gestures when interacting with others. As VR grows as a tool and communication platform, it is important to understand how the rising prevalence of hand-tracking technology might affect users' experiences.

The goal of this dissertation is to investigate, through a series of experiments, how using hand motions in VR influences …

Measurement And Evaluation Of Roadway Geometry For Safety Analyses And Pavement Material Volume Estimation For Resurfacing And Rehabilitation Using Mobile Lidar And Imagery-Based Point Clouds, Leonildo Nelson Cassule

All Dissertations

Roadway safety is a multifaceted issue affected by several variables including geometric design features of the roadway, weather conditions, sight distance issues, user behavior, and pavement surface condition. In recent years, transportation agencies have demonstrated a growing interest in utilizing Light Detecting and Ranging (LiDAR) and other remote sensing technologies to enhance data collection productivity, safety, and facilitate the development of strategies to maintain and improve existing roadway infrastructure. Studies have shown that three-dimensional (3D) point clouds acquired using mobile LiDAR systems are highly accurate, dense, and have numerous applications in transportation. Point cloud data applications include extraction of roadway …

Behavioral Ecology Of The American Alligator (Alligator Mississippiensis) In Human-Dominated Landscapes Of Coastal South Carolina, Anjelika Kidd-Weaver

All Dissertations

When wildlife habitat is developed to accommodate growing human populations, wildlife are forced to move to undisturbed landscapes or to acclimate to a novel, anthropogenic environment. In this dissertation, we investigated the behavior and ecology of the American alligator (Alligator mississippiensis) in coastal, residential resort communities with an overarching goal of identifying behavioral patterns of alligators that can inform risk management strategies. In Chapter One, we compared the space use of male and female alligators in primarily wetland versus residential landscapes across three seasons to determine if and how space use behaviors of alligators differ. We found that …

On Variants Of Sliding And Frank-Wolfe Type Methods And Their Applications In Video Co-Localization, Seyed Hamid Nazari

All Dissertations

In this dissertation, our main focus is to design and analyze first-order methods for computing approximate solutions to convex, smooth optimization problems over certain feasible sets. Specifically, our goal in this dissertation is to explore some variants of sliding and Frank-Wolfe (FW) type algorithms, analyze their convergence complexity, and examine their performance in numerical experiments. We achieve three accomplishments in our research results throughout this dissertation. First, we incorporate a linesearch technique to a well-known projection-free sliding algorithm, namely the conditional gradient sliding (CGS) method. Our proposed algorithm, called the conditional gradient sliding with linesearch (CGSls), does not require the …

Quantifying And Identifying Mechanisms Of Resistance To Thrips (Thysanoptera: Thripidae) In Landraces Of Upland Cotton (Gossypium Hirsutum), Sophia Christian

All Dissertations

Throughout the southeastern USA, tobacco thrips (Frankliniella fusca Hinds) are the primary thrips (Thysanoptera: Thripidae) pest species of cotton (Gossypium spp.) seedlings and are often detrimental to the establishing crop. In 2020, cotton yield losses from thrips and their management cost USA growers $70.7 million. Heavy reliance on prophylactic insecticides, primarily used as seed treatments, has led to insecticide-resistant populations of tobacco thrips. Currently, no known commercial cotton cultivar provides protection to prevent injury from thrips feeding. A sustainable, alternative management tactic is needed to address insecticide-resistant populations of and reduce damage from thrips in cotton. Our research evaluated day-neutral, …

A New Comprehensive And Practical Taxonomy Of Demands Healthcare Professionals Experience: The Development Process And Testing Using Machine Learning, Phoebe Xoxakos

All Dissertations

Given the complex (Ratnapalan & Lang, 2020) and high stress environment of healthcare organizations (Freshwater & Cahill, 2010), a better understanding of the conditions in which healthcare professionals work is important. Although previous research has resulted in somewhat limited categories of the demands on healthcare professionals (Borteyrou et al., 2014; Shanafelt et al., 2020), a comprehensive taxonomy that covers the breadth and depth of demands is lacking. Using longitudinal data collected over 28 measurement waves spanning two years during the COVID-19 pandemic, the present studies outline the development of a taxonomy based on an in-depth literature review of related workplace …

Estimation Of Disaggregated Import Demand Functions For Nigeria, Chekwube V. Madichie, Uche C. Nwogwugwu, Franklin N. Ngwu, Olisaemeka D. Mauka

CBN Journal of Applied Statistics (JAS)

This paper estimates disaggregated import demand function for Nigeria using annual data from 1970 to 2019. The study employs the Zivot-Andrews unit root and Gregory-Hansen cointegration tests to account for the role of structural breaks and the error correction mechanism for shortrun analysis, respectively. The results show that household consumption, industrial output and domestic investment are the major determinants of import demand for consumer, intermediate and investment goods, respectively. Furthermore, the import demand for investment goods is not sensitive to variations in relative prices. However, relative prices is negative and significant to import demand for consumer and intermediate goods. Exchange …

Size And Determinants Of The Shadow Economy In Nigeria: Evidence From A Monetary Approach, Tari M. Karimo, Mohammed M. Tumala, Ibrahim U, Wambai

CBN Journal of Applied Statistics (JAS)

Thiis study investigates the size and determinants of the shadow economy in Nigeria. It adopts an aggregation approach within the monetary framework and utilises the ARDL estimation technique to analyse quarterly data from 2010 Q1 to 2019 Q4. On average, the results suggest that the quarterly size of the shadow economy is about 55 per cent of the country’s GDP. The findings show that government size reduces the size of the shadow economy in the short run but increases it in the long run. The study also finds that interest rate, which is the opportunity cost of holding cash, and …

Market Risk Factors And Stock Returns In The Nigerian Bourse, Omorose A. Ogiemudia, Osagie Osifo, Igbinovia L. Eghosa

CBN Journal of Applied Statistics (JAS)

This study examines the link between market risk and equity return in Nigeria between 1980 to 2019. It employs the vector error correction model (VECM) to determine the short run dynamics and long run effect of market risk factors on stock return. The findings revealed that a dynamic relationship exists between market risk factors and stock returns in Nigeria. Also, exchange rate risk and oil price risks have significant influence on stock return, while inflation and interest rate risk, and political instability risks have a non-significant impact on stock return. Finally, a unidirectional relationship was detected between interest rate, oil …

Savings-Investment Gap In Sub-Saharan Africa: Does The Interaction Of Financial Sector Development And Migrant Remittances Matter?, Wasiu Adekunle, Oluwatosin Adeniyi, Joshua Afolabi, Musibau Babatunde, Edward Omiwale

CBN Journal of Applied Statistics (JAS)

This study analyses the interactive effects of migrant remittances and financial development on savings-investment gap for a panel of 18 Sub-Saharan Africa (SSA) countries from 1990-2017. Results from a panel ARDL model show that migrant remittances reduce savings-investment gap in the long run. The gap is further reduced when the individual effect of financial development, and the interactive effects of migrant remittances and financial development are taken into consideration. Further analysis reveals evidence of widening effects of rising real GDP growth and bank deposits over a long-term horizon, while higher private sector credit widened the savings-investment gap only in the …

Impact Of Exchange Rate On Trade Flow In Nigeria, Victor U. Ijirshar, Isa J. Okpe, Jerome T. Andohol

CBN Journal of Applied Statistics (JAS)

This study examines the impact of exchange rate on trade flow in Nigeria from 1986 to 2021. The study utilises linear and nonlinear autoregressive distributed lag (ARDL and NARDL) models to test the J-Curve hypothesis and the Marshall-Lerner condition in Nigeria. The study found symmetric effects of exchange rate on trade balance, exports, and imports. The findings also show that real exchange rate depreciation has a strong negative influence on trade balance and exports in the short run but positive in the long run, exhibiting the shape typology of the J-curve. Furthermore, the study reveals evidence of the Marshall-Lerner condition …

Effects Of Central Bank Independence And Financial Stability On Inflation In Selected African Countries, Adamu Yahaya, Mohammed T. Saidu, Abdulaziz Sadi

CBN Journal of Applied Statistics (JAS)

This study examines the relationship between central bank independence (CBI), financial stability, and inflation in 14 African countries within the period 1985-2019. Initial test revealed the presence of cross-sectional dependence (CD) among the countries. Thus, the Mean Group (MG), Common Correlated Effect Mean Group (CCEMG) and Augmented Mean Group (AMG) were employed for the analysis. The CCEMG and AMG results showed a significant and negative correlation between central bank independence and inflation. On the other hand, financial stability is only significant in the MG Model. Additional results obtained using the Garriga CBI index is consistent with our main results. The …

Full Issue

Criterion: A Journal of Literary Criticism

No abstract provided.

The Only Way Out Is Through: Community, Death, And The Desacralization Of Trauma In George Saunders’ Lincoln In The Bardo, Josey Gardner

Criterion: A Journal of Literary Criticism

The arrival of George Saunders’ novel Lincoln in the Bardo as yet another trauma narrative is not surprising. What began as a desire for representation of trauma in media and literature has morphed into an obsession in which trauma is the gold standard. Upon becoming so, trauma is inevitably placed upon a pedestal—the shining object that all other decisions are measured against and based upon. Its placement on this pedestal marks the “sacralization” of trauma. However, Lincoln in the Bardo fills a unique niche in the current portrayals of trauma found in popular media by seeking to minimize its importance …

The Fire Of Love: Medieval Mysticism And The Role Of Women In Religion And The Production Of Texts, Claire Siewert

English Honors Theses

No abstract provided.

The Search For Spices And Souls: Catholic Missions As Colonial State In The Philippines, Dean C. Dulay

Research Collection School of Social Sciences

A growing literature posits that colonial Christian missions brought schooling to the colonies, improving human capital in ways that persist to this day. But in some places they did much more. This paper argues that colonial Catholic missions in the Philippines functioned as state-builders, establishing law and order and building fiscal and infrastructural capacities in territories they controlled. The mission-as-state was the result of a bargain between the Catholic missions and the Spanish colonial government: missionaries converted the population and engaged in state-building, whereas the colonial government reaped the benefits of state expansion while staying in the capital. Exposure to …

From Guo To Tianxia: Linking Two Daoist Theories Of International Relations, Devin K. Joshi

Research Collection School of Social Sciences

This study examines the international relations theory (IRT) of Daoism, one of Asia’s long-standing traditions to have theorized international politics. Drawing upon Laozi’s Dao De Jing, this study elucidates two Daoist IR theories. First, Laozi provides a state-focused guo-based IRT for conducting foreign policy and managing inter-state relations with emphasis on yielding and softness to overcome violence and domination. Second, Laozi offers a Utopian and globalist tianxia-centered IRT based on following the Dao whereby inter-state rivalry is dissolved in favor of peaceful planetary governance in harmony with the natural rhythms of the cosmos. Whereas previous scholarship often concentrates on only …

"Keep To The Code”: A Global Code Of Conduct For Third-Party Funders, Victoria Sahani

Faculty Scholarship

Global commercial third-party funding has given rise to wide-ranging regulatory approaches worldwide. Consequently, funders can engage in cross-border regulatory arbitrage by exploiting regulatory gaps within and among nations. This Article argues that the global community of nations should articulate a universal approach to the behavioral expectations of third-party funders operating transnationally, independent of local laws regarding the technical business of funding. It asserts that the key to fostering the ethical development of the third-party funding industry is to develop a globally applicable but locally enforced code of conduct or professional responsibility for the industry. Moreover, a successful regime for funder …

Contracts Scholarship Beyond Materialisierung, Daniela Caruso

Faculty Scholarship

This comment aims to show how Klaus Eller's paper on ‘The Political Economy of Tenancy Contract Law raises the stakes of private law scholarship and contributes to the larger project of remodeling legal institutions in a progressive direction. The comment starts by contextualising the rapid spread of the Law and Political Economy (LPE) movement; illustrates through examples the generative impact of LPE on contemporary contracts scholarship; and highlights two strands of Eller’s original contribution to such literature: a welcome reflection on the value and limits of Materialisierung, and a radical widening of the private law inquiry to include institutional …