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2022

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Cdc’S Covid-19 Vaccination Messages And Public Engagement: A Study On Facebook Posts, Hasan Mahmud Faisal Dec 2022

Cdc’S Covid-19 Vaccination Messages And Public Engagement: A Study On Facebook Posts, Hasan Mahmud Faisal

Master's Theses

Government health agencies utilize social media for public health interventions. This study examines how CDC, the national public health agency of the United States, use Facebook to disseminate COVID-19 vaccine messages and to get public engagement towards them over the past two years (2020-2022). Investigating the process of dialogic potentials of Facebook from the dialogic theory of public relations perspective, the current study analyzes 681 posts and 3,405 comments from CDC’s official Facebook page. Thematic analysis of posts yields three dominant themes such as “Vaccine supportive”, “availability of vaccine”, and “up to date information”. Comment analysis shows positive sentiment to …


International Pooled Patient-Level Meta-Analysis Of Ketamine Infusion For Depression: In Search Of Clinical Moderators, Rebecca B Price, Nicholas Kissel, Andrew Baumeister, Rebecca Rohac, Mary L Woody, Elizabeth D Ballard, Carlos A Zarate, William Deakin, Chadi G Abdallah, Adriana Feder, Dennis S Charney, Michael F Grunebaum, J John Mann, Sanjay J Mathew, Bronagh Gallagher, Declan M Mcloughlin, James W Murrough, Suresh Muthukumaraswamy, Rebecca Mcmillan, Rachael Sumner, George Papakostas, Maurizio Fava, Rebecca Hock, Jennifer L Phillips, Pierre Blier, Paulo Shiroma, Peter Šóš, Tung-Ping Su, Mu-Hong Chen, Mikael Tiger, Johan Lundberg, Samuel T Wilkinson, Meredith L Wallace Dec 2022

International Pooled Patient-Level Meta-Analysis Of Ketamine Infusion For Depression: In Search Of Clinical Moderators, Rebecca B Price, Nicholas Kissel, Andrew Baumeister, Rebecca Rohac, Mary L Woody, Elizabeth D Ballard, Carlos A Zarate, William Deakin, Chadi G Abdallah, Adriana Feder, Dennis S Charney, Michael F Grunebaum, J John Mann, Sanjay J Mathew, Bronagh Gallagher, Declan M Mcloughlin, James W Murrough, Suresh Muthukumaraswamy, Rebecca Mcmillan, Rachael Sumner, George Papakostas, Maurizio Fava, Rebecca Hock, Jennifer L Phillips, Pierre Blier, Paulo Shiroma, Peter Šóš, Tung-Ping Su, Mu-Hong Chen, Mikael Tiger, Johan Lundberg, Samuel T Wilkinson, Meredith L Wallace

Children’s Nutrition Research Center Staff Publications

Depression is disabling and highly prevalent. Intravenous (IV) ketamine displays rapid-onset antidepressant properties, but little is known regarding which patients are most likely to benefit, limiting personalized prescriptions. We identified randomized controlled trials of IV ketamine that recruited individuals with a relevant psychiatric diagnosis (e.g., unipolar or bipolar depression; post-traumatic stress disorder), included one or more control arms, did not provide any other study-administered treatment in conjunction with ketamine (although clinically prescribed concurrent treatments were allowable), and assessed outcome using either the Montgomery-Åsberg Depression Rating Scale or the Hamilton Rating Scale for Depression (HRSD-17). Individual patient-level data for at least …


Mind The Gaps: Assessing And Enhancing The Trustworthiness Of Mental Health Apps, Gary Kok Yew Chan Dec 2022

Mind The Gaps: Assessing And Enhancing The Trustworthiness Of Mental Health Apps, Gary Kok Yew Chan

Research Collection Yong Pung How School Of Law

Mental health apps including artificial intelligence (“AI”)- powered apps and chatbots have raised serious concerns relating to safety, efficacy and privacy. This article assesses their trustworthiness based on lego-regulatory, ethical and technological measures in addressing the abovementioned concerns. Focusing on applications to mental health apps, it examines Singapore laws, regulations and guidelines relating to software-based and AI medical devices, data protection, consumer protection, advertising and medical negligence. Additionally, upon taking into account other non-binding ethical guidelines, certification standards and technological measures targeted at app developers, a few recommendations are offered for enhancing trust in mental health apps.


The Effects Of Virtual Reality On Mental Health Software User Satisfaction And Retention, William Hooten Dec 2022

The Effects Of Virtual Reality On Mental Health Software User Satisfaction And Retention, William Hooten

Honors Theses

Mental health issues have become increasingly important in today's society. With that being said, researchers and consumers are looking for new ways to manage and treat mental health using new technologies in labs and the consumer space. This innovation has led to the presence of mobile self-help mental health applications, applications for peoples’ phones that are used to manage symptoms of mental health problems, such as depression and anxiety, track goals, meditate, and more. However, mobile mental health applications, and mobile applications in general, have a problem concerning user satisfaction and overall user retention – studies have shown that 95% …


Beyond The Classroom: Building Professional Skills With The Flyaway Mural, Augusta Gaston Dec 2022

Beyond The Classroom: Building Professional Skills With The Flyaway Mural, Augusta Gaston

Honors Theses

In April of 2022, I completed a collaborative mural at Reflection Riding Arboretum and Nature Center in Chattanooga, Tennessee. Reflection Riding hosts a radio antenna connected to the Motus Wildlife Tracking System, which studies animal migration routes through North, Central, and South America. Working collaboratively with artists Rondell Crier, Tyus Allen, and Professor Derek Witucki, we designed and installed a mural that would communicate the Motus research to their visitors in the absence of a Reflection Riding employee. The project was funded by various grants awarded by ArtsBuild and The University of Tennessee at Chattanooga, and organized by budgets that …


Study Of Collective Self-Esteem And Academic Motivation Examining Perceptions Of Academic Statistics Of Black Traditional Undergraduate Students Attending A Pwi, Ariyah Robinson Dec 2022

Study Of Collective Self-Esteem And Academic Motivation Examining Perceptions Of Academic Statistics Of Black Traditional Undergraduate Students Attending A Pwi, Ariyah Robinson

Honors Theses

College enrollment for black traditional college-age students has been on the rise. Matriculation experienced a seven percent increase from 2000 to 2018 (NCES, 2020). However, Cokley et al. (2013) found that black students exhibit the highest minority stress among college students. Researchers also found that students may feel pressured to break stereotypes and perform well academically (Smith & Hope, 2020; Brooms, 2019; Mary et al., 2018). As more black students enroll in colleges nationwide, there is more than reasonable cause to continue examining how the matriculation of black students into predominantly white institutions impacts black students and their perceptions of …


Pattern Of Health Care Utilization And Cost Among Alzheimer's Emergency Department Patients In South Carolina, Caitlin Torrence Dec 2022

Pattern Of Health Care Utilization And Cost Among Alzheimer's Emergency Department Patients In South Carolina, Caitlin Torrence

All Dissertations

Alzheimer’s disease and related dementias (ADRD) affect millions of people worldwide; however, there has yet to be a method of prevention or cure developed. In the United States (US) and other developed nations, healthcare utilization and cost associated with ADRD is pronounced. In 2018, healthcare costs totaled $259 billion in the US. The current system of care is fracturing under the pressure caused by ADRD and other illnesses. To begin addressing the public health crisis, this dissertation uses the South Carolina (SC) Alzheimer’s Disease Registry (AD Registry) and the SC Emergency Department (ED) Patient Encounter Data to analyze 11 years …


Therapeutic Exercise Programming For Nonspecific Low Back Pain, Kendal F. Huepper Dec 2022

Therapeutic Exercise Programming For Nonspecific Low Back Pain, Kendal F. Huepper

Senior Honors Theses

Nonspecific low back pain is a prevalent cause of injury and disability in the world today. However, most people with this condition continue to live in discomfort because they do not know how reduce their pain. Exercise is one of the many ways that those with lumbar pain can find relief. By combining a wide variety of exercises that have been shown to reduce pain while increasing strength, range of motion, activity, and functionality, this thesis attempts to create an evidence-based generalized therapeutic exercise program that those with nonspecific low back pain can utilize to live an active and healthy …


Increasing Self-Determination Skill Through Behavioral Skills Training For Individuals With Extensive Support Needs To Examine Reversible Contraceptive Choices., Jennifer Pollard Dec 2022

Increasing Self-Determination Skill Through Behavioral Skills Training For Individuals With Extensive Support Needs To Examine Reversible Contraceptive Choices., Jennifer Pollard

Electronic Theses and Dissertations

There is a long history of individuals with extensive support needs (ESN) being sterilized without their knowledge and consent. Students with ESN are defined as individuals who need continuous and widespread supports necessary for academic, communication, and/or daily living skills. These individuals typically have more than one diagnosis including a developmental disability (DD), intellectual disability (ID), and/or traumatic brain injury (Kurth et al., 2019; Taub et al., 2017). Part of the reason this is able to occur is due to a lack of education about sexual development and a lack of interventions to build skills related to self-determination or informed …


Neonate, Infant, And Child Mortality In North Africa And Middle East By Cause: An Analysis For The Global Burden Of Disease Study 2019, Sadaf G. Sepanlou, Hossein Rezaei Aliabadi, Reza Malekzadeh, Ali. A. Asadi-Pooya Dec 2022

Neonate, Infant, And Child Mortality In North Africa And Middle East By Cause: An Analysis For The Global Burden Of Disease Study 2019, Sadaf G. Sepanlou, Hossein Rezaei Aliabadi, Reza Malekzadeh, Ali. A. Asadi-Pooya

Global Health Articles

Background: During the past three decades, neonate, infant, and child mortality declined in North Africa and Middle East. However, there is substantial heterogeneity in mortality rates across countries.

Methods: This study is part of the Global Burden of Diseases study (GBD) 2019. We report the number as well as mortality rates for neonates, infants, and children by cause across 21 countries in the region since 1990.

Results: Between 1990 and 2019, the neonate mortality rate in the region declined from 31.9 (29.8, 34.0) to 12.2 (11.1, 13.3) per 1000 live births. Respective figures for under 5 mortality rates (U5MRs) were …


The Student Movement Volume 107 Issue 10: Finals Week Is About To Get Messi, Gloria Oh, Nora Martin, Amelia Stefanescu, Solana Campbell, Abraham Bravo, Ceiry Flores, Hannah Cruse, Andrew Francis, Bella Hamann, Gabriela Francisco, Valerie Akinyi, Ruben Colón, Charisse Lapuebla, Alannah Tjhatra Dec 2022

The Student Movement Volume 107 Issue 10: Finals Week Is About To Get Messi, Gloria Oh, Nora Martin, Amelia Stefanescu, Solana Campbell, Abraham Bravo, Ceiry Flores, Hannah Cruse, Andrew Francis, Bella Hamann, Gabriela Francisco, Valerie Akinyi, Ruben Colón, Charisse Lapuebla, Alannah Tjhatra

The Student Movement v. 107 (2022-2023)

HUMANS

Introducing Active Minds Club, Gloria Oh

Women in STEM: Bia Martins, Interviewed by: Nora Martin

Women in STEM: Davielle Smith, Interviewed by: Gloria Oh

ARTS & ENTERTAINMENT

Art Majors at AU: Graphic Design, Amelia Stefanescu

Currently..., Solana Campbell

Immersed in a Musical Wonderland, Abraham Bravo

What did AU Watch over Break?. Ceiry Flores

NEWS

Act 22 and Statehood: What is the Answer to Puerto Rico's problems?, Hannah Cruse

AU Abroad "Shark Tank" Winners Prepare for Spring Start, Andrew Francis

Student Debt Cancellation: Updates and Thought, Gloria Oh

IDEAS

From Cover to Cover: Braking out of the Adventist Bubble, Bella …


(R1995) Weighted Block-Wise Burst Error Correcting Codes, Amita Sethi, Arpana Sharma Dec 2022

(R1995) Weighted Block-Wise Burst Error Correcting Codes, Amita Sethi, Arpana Sharma

Applications and Applied Mathematics: An International Journal (AAM)

In this paper, we construct new types of codes, called Weighted Block-wise Burst Error Correcting Codes (Weighted BBEC Codes), which are an improvement on the previously known block wise burst error correcting codes in the sense of their weight, i.e., (n = n1 + n2, k) linear codes that correct all the bursts of length b1 (fixed) with the weight w1 (w1 ≤ b1) or more (less) in the first sub-block of length n1 and all the bursts of length b2 (fixed) with the weight w2 or more (less) …


Design And Synthesis Towards Bifunctional 89zr And 44sc Chelators For Immuno-Positron Emission Tomography, Noah Cote Dec 2022

Design And Synthesis Towards Bifunctional 89zr And 44sc Chelators For Immuno-Positron Emission Tomography, Noah Cote

Master's Theses and Capstones

The design and synthesis of novel zirconium and scandium complexes, ZrIV(p-NO2-sal-DFO) and ScIII(p-NO2-Bn-NOTPi) respectively, and their potential for use in immuno-positron emission tomography (immuno-PET) are discussed. The design for a linear octadentate ligand for Zr was hypothesized and derived from deferoxamine B (DFO), a well-known hexadentate siderophore for Fe complexation. A p-NO2-salicyclic acid derivative was prepared to provide a bifunctional handle for antibody conjugation. Deferoxamine B chelates with hydroxamate moieties, which have proven useful for chelation of hard acids. While difficulties in purification led to no complexation studies being performed, this chelator was confirmed via 1H NMR , 13C NMR, …


Cosmogenic 36cl Dating Of The Granite Canyon Moraine Complex In The Teton Range To Determine Fault Offset Rates And The Influence Of Valley Hypsometry On Glacier Behavior, Calen M. Rubin Dec 2022

Cosmogenic 36cl Dating Of The Granite Canyon Moraine Complex In The Teton Range To Determine Fault Offset Rates And The Influence Of Valley Hypsometry On Glacier Behavior, Calen M. Rubin

Master's Theses and Capstones

During the Last Glacial Maximum, major drainages along the east side of the Teton Range were occupied by alpine glaciers that extended to the floor of Jackson Hole. Chronologies of glaciation in the central and northern parts of the range have been developed via 10Be exposure dating of well-preserved terminal and lateral moraine complexes. However, few glacial records have been developed in the southern portion of the range. The metamorphic and sedimentary bedrock and shallow hypsometry of Granite Canyon stand in contrast to the crystalline lithology and steeper hypsometry of glaciated valleys further north along the eastern range front. Granite …


Textualism And The Indian Canons Of Statutory Construction, Alex Tallchief Skibine Dec 2022

Textualism And The Indian Canons Of Statutory Construction, Alex Tallchief Skibine

University of Michigan Journal of Law Reform

When interpreting statutes enacted for the benefit or regulation of Indians or construing treaties signed with Indian nations, courts are supposed to apply any of five specific canons of construction relating to Indian Affairs. Through examining the modern line of Supreme Court cases involving statutory or treaty interpretation relating to Indian nations, this Article demonstrates that the Court has generally been faithful in applying canons relating to treaty interpretation or abrogation. The Court has also respected the canon requiring unequivocal expression of congressional intent before finding an abrogation of tribal sovereign immunity. However, there are two other canons that the …


The Times They Are A-Changin’?: #Metoo And Our Movement Forward, Terry Morehead Dworkin, Cindy A. Schipani Dec 2022

The Times They Are A-Changin’?: #Metoo And Our Movement Forward, Terry Morehead Dworkin, Cindy A. Schipani

University of Michigan Journal of Law Reform

Social movements like #MeToo have gained public traction like never before. In this Article, we place those developments within their historical context and chart a path forward. First, we provide a history of the prior unsuccessful attempts to ratify an Equal Rights Amendment, and we discuss that effort’s current legal status and prospects. Then, we briefly review the history of sexual harassment law. Having outlined this historical context, we move to contemporary developments. We describe actions that state legislatures and local municipalities have taken to address the concerns raised by the #MeToo movement. Finally, we discuss how inflection points can …


The Fed Of The Future: A Framework To Optimize Short-Term Lending Practices, Emma Macfarlane, Karin Thrasher Dec 2022

The Fed Of The Future: A Framework To Optimize Short-Term Lending Practices, Emma Macfarlane, Karin Thrasher

University of Michigan Journal of Law Reform

Underbanked individuals currently face significant risk when accessing short-term credit. While payday loans are the least expensive short-term credit option when compared to alternatives like overdraft fees, they can also have an extraordinarily high cost of borrowing. Unable to pay the cost of the loan, borrowers often find themselves in a vicious cycle that drives them further into debt. This Note sets forth a proposal as to how payday loans can be better regulated to create affordable access to short-term credit. Specifically, this Note advocates for congressional and Federal Reserve intervention in the payday lending market.

This Note first analyzes …


Rethinking Absolute Immunity From Defamation Suits In Private Quasi-Judicial Proceedings Dec 2022

Rethinking Absolute Immunity From Defamation Suits In Private Quasi-Judicial Proceedings

The University of New Hampshire Law Review

No abstract provided.


Pop & Perjury: The Irs Valuation War With The Estate Of Michael Jackson Dec 2022

Pop & Perjury: The Irs Valuation War With The Estate Of Michael Jackson

The University of New Hampshire Law Review

When Michael Jackson died unexpectedly in Los Angeles, California, on June 25, 2009, his career and earnings were nearing an all-time low. Plagued by past sexual abuse allegations, scandals, and questionable health, Michael Jackson’s personal finances were purported to be in complete disarray. However, following his unexpected death, the value of his estate, which was reported to be near to nothing, swelled as the world remembered his beloved contributions to the world and began to purchase accordingly. Sales of Michael Jackson’s music began to soar high. The estate’s value soared even higher as it signed licensing agreements and released new …


Broken Promises: The Granite State’S Return To The Institutionalization Of Children With Disabilities Dec 2022

Broken Promises: The Granite State’S Return To The Institutionalization Of Children With Disabilities

The University of New Hampshire Law Review

In 1975, the New Hampshire legislature enacted a progressive statute which mandated the Department of Health and Human Services “to establish, maintain, implement and coordinate a comprehensive service delivery system for developmentally disabled persons.” This law was innovative for its time; it decreed that individual service plans (ISPs) be developed for every client in the state’s service delivery system, guaranteed “a right to adequate and humane habilitation and treatment[,]” and contemplated the state’s area agency system as we know it today. The statute was a steppingstone for the 1981 class action lawsuit of Garrity v. Gallen. This was one of …


Bobcat Identification, Abundance, And Behavior At Road Mitigation Structures In South Texas, Victoria Hanley Dec 2022

Bobcat Identification, Abundance, And Behavior At Road Mitigation Structures In South Texas, Victoria Hanley

Theses and Dissertations

Highways in South Texas fragment the landscape and result in high road mortality rates for the endangered US ocelot (Leopardus pardalis). In response, the Texas Department of Transportation constructed nine wildlife crossing structures (WCS) on Farm-to-Market (FM) 106 which adjoins Laguna Atascosa National Wildlife Refuge in Cameron County, Texas. With ocelots being rare and elusive, bobcats (Lynx rufus) are often used as a surrogate species to study felid behavior at road mitigation structures in South Texas. Bobcats have unique markings which allow them to be individually identified. Three methods of individual identification of bobcats using camera …


The Role Of Lncrna Uca1 In Colorectal Cancer Progression And Metastasis, Sophia M. Leslie Dec 2022

The Role Of Lncrna Uca1 In Colorectal Cancer Progression And Metastasis, Sophia M. Leslie

Theses and Dissertations

Colorectal cancer (CRC) is the primary cause of cancer-related deaths worldwide, and it is the third most common cancer diagnosed in adults in the United States according to the American Cancer Society. We have identified lncRNA UCA1, a poor prognosis marker in CRC, responsible for increased proliferation and upregulating key genes related to glucose metabolism. Recombinant cell lines were generated to overexpress and knockdown UCA1 to establish the phenotype and to investigate the properties endowed in metastasis. A vital aspect of the metastatic progression is when the cell survives detachment from the extracellular matrix. At 36 hours of anchorage-independent stimulation, …


Association Of Initial Sars-Cov-2 Test Positivity With Patient-Reported Well-Being 3 Months After A Symptomatic Illness., Lauren E Wisk, Michael A Gottlieb, Erica S Spatz, Huihui Yu, Ralph C Wang, B. H. Slovis, Sharon Saydah, Ian D Plumb, Kelli N O'Laughlin, Juan Carlos C Montoy, Samuel A Mcdonald, Zhenqiu Lin, Jin-Mann S Lin, Katherine Koo, Ahamed H Idris, Ryan M Huebinger, Mandy J Hill, Nicole L Gentile, Anna Marie Chang, Jill Anderson, Bala Hota, Arjun K Venkatesh, Robert A Weinstein, Joann G Elmore, Graham Nichol Dec 2022

Association Of Initial Sars-Cov-2 Test Positivity With Patient-Reported Well-Being 3 Months After A Symptomatic Illness., Lauren E Wisk, Michael A Gottlieb, Erica S Spatz, Huihui Yu, Ralph C Wang, B. H. Slovis, Sharon Saydah, Ian D Plumb, Kelli N O'Laughlin, Juan Carlos C Montoy, Samuel A Mcdonald, Zhenqiu Lin, Jin-Mann S Lin, Katherine Koo, Ahamed H Idris, Ryan M Huebinger, Mandy J Hill, Nicole L Gentile, Anna Marie Chang, Jill Anderson, Bala Hota, Arjun K Venkatesh, Robert A Weinstein, Joann G Elmore, Graham Nichol

Department of Emergency Medicine Faculty Papers

IMPORTANCE: Long-term sequelae after symptomatic SARS-CoV-2 infection may impact well-being, yet existing data primarily focus on discrete symptoms and/or health care use.

OBJECTIVE: To compare patient-reported outcomes of physical, mental, and social well-being among adults with symptomatic illness who received a positive vs negative test result for SARS-CoV-2 infection.

DESIGN, SETTING, AND PARTICIPANTS: This cohort study was a planned interim analysis of an ongoing multicenter prospective longitudinal registry study (the Innovative Support for Patients With SARS-CoV-2 Infections Registry [INSPIRE]). Participants were enrolled from December 11, 2020, to September 10, 2021, and comprised adults (aged ≥18 years) with acute symptoms suggestive …


Intermediate Algebra Students’ Perspectives Towards Learning Mathematics, And Technology, Caree J. S. Pinder Dec 2022

Intermediate Algebra Students’ Perspectives Towards Learning Mathematics, And Technology, Caree J. S. Pinder

USF Tampa Graduate Theses and Dissertations

Research states that many remedial mathematics learners possess low mathematics academic self-concept, negative attitudes, and high anxiety levels. These aspects can manifest in a lack of confidence, apprehension, reduced engagement, or academic failure (2007; Klinger, 2008; Larkin & Jorgensen, 2016; Parnis & Petocz, 2016;). However, if these learners successfully pass remedial mathematics courses like Intermediate Algebra, they are more likely to persist in mathematics and the university (Benken et al., 2015). Due to students' success in remedial mathematics, persistence in mathematics raises many questions. In many cases, these students have had unpleasant experiences, attitudes, or beliefs about mathematics but were …


Diurnal Rnapii-Tethered Chromatin Interactions Are Associated With Rhythmic Gene Expression In Rice, Li Deng, Baibai Gao, Lun Zhao, Ying Zhang, Qing Zhang, Minrong Guo, Yongqing Yang, Shuangqi Wang, Liang Xie, Hao Lou, Meng Ma, Wei Zhang, Zhilin Cao, Qinghua Zhang, C. Robertson Mcclung, Guoliang Li, Xingwang Li Dec 2022

Diurnal Rnapii-Tethered Chromatin Interactions Are Associated With Rhythmic Gene Expression In Rice, Li Deng, Baibai Gao, Lun Zhao, Ying Zhang, Qing Zhang, Minrong Guo, Yongqing Yang, Shuangqi Wang, Liang Xie, Hao Lou, Meng Ma, Wei Zhang, Zhilin Cao, Qinghua Zhang, C. Robertson Mcclung, Guoliang Li, Xingwang Li

Dartmouth Scholarship

Background: The daily cycling of plant physiological processes is speculated to arise from the coordinated rhythms of gene expression. However, the dynamics of diurnal 3D genome architecture and their potential functions underlying the rhythmic gene expression remain unclear. Results: Here, we reveal the genome-wide rhythmic occupancy of RNA polymerase II (RNAPII), which precedes mRNA accumulation by approximately 2 h. Rhythmic RNAPII binding dynamically correlates with RNAPII-mediated chromatin architecture remodeling at the genomic level of chromatin interactions, spatial clusters, and chromatin connectivity maps, which are associated with the circadian rhythm of gene expression. Rhythmically expressed genes within the same peak phases …


Enhanced Cell Deconvolution Of Peripheral Blood Using Dna Methylation For High-Resolution Immune Profiling, Lucas A. Salas, Ze Zhang, Devin C. Koestler, Rondi A. Butler, Helen M. Hansen, Annette M. Molinaro, John K. Wiencke, Karl T. Kelsey, Brock C. Christensen Dec 2022

Enhanced Cell Deconvolution Of Peripheral Blood Using Dna Methylation For High-Resolution Immune Profiling, Lucas A. Salas, Ze Zhang, Devin C. Koestler, Rondi A. Butler, Helen M. Hansen, Annette M. Molinaro, John K. Wiencke, Karl T. Kelsey, Brock C. Christensen

Dartmouth Scholarship

DNA methylation microarrays can be employed to interrogate cell-type composition in complex tissues. Here, we expand reference-based deconvolution of blood DNA methylation to include 12 leukocyte subtypes (neutrophils, eosinophils, basophils, monocytes, naïve and memory B cells, naïve and memory CD4 + and CD8 + T cells, natural killer, and T regulatory cells). Including derived variables, our method provides 56 immune profile variables. The IDOL (IDentifying Optimal Libraries) algorithm was used to identify libraries for deconvolution of DNA methylation data for current and previous platforms. The accuracy of deconvolution estimates obtained using our enhanced libraries was validated using artificial mixtures and …


Evolution Of The Repression Mechanisms In Circadian Clocks, Jonathan Tyler, Yining Lu, Jay Dunlap, Daniel B. Forger Dec 2022

Evolution Of The Repression Mechanisms In Circadian Clocks, Jonathan Tyler, Yining Lu, Jay Dunlap, Daniel B. Forger

Dartmouth Scholarship

Background: Circadian (daily) timekeeping is essential to the survival of many organisms. An integral part of all circadian timekeeping systems is negative feedback between an activator and repressor. However, the role of this feedback varies widely between lower and higher organisms. Results: Here, we study repression mechanisms in the cyanobacterial and eukaryotic clocks through mathematical modeling and systems analysis. We find a common mathematical model that describes the mechanism by which organisms generate rhythms; however, transcription’s role in this has diverged. In cyanobacteria, protein sequestration and phosphorylation generate and regulate rhythms while transcription regulation keeps proteins in proper stoichiometric balance. …


Enabling Decision-Making In Battery Electric Bus Deployment Through Interactive Visualization, Xiaoyue Cathy Liu, Gabrielius Kudirka, Biao Kuang, Yirong Zhou, Jianlin Chen Dec 2022

Enabling Decision-Making In Battery Electric Bus Deployment Through Interactive Visualization, Xiaoyue Cathy Liu, Gabrielius Kudirka, Biao Kuang, Yirong Zhou, Jianlin Chen

TREC Final Reports

The transit industry is rapidly transitioning to battery-electric fleets because of the direct environmental and financial benefits they could offer, such as zero emissions, less noise, and lower maintenance costs. Yet the unique spatiotemporal characteristics associated with transit system charging requirements, as well as various objectives when prioritizing the fleet electrification, requires the system operators and/or decision-makers to fully understand the status of the transit system and energy/power system in order to make informed deployment decisions. A recently completed NITC project, No. 1222 titled An Electric Bus Deployment Framework for Improved Air Quality and Transit Operational Efficiency, developed a bi-objective …


Climate Justice And Racial And Gender Equity: Creating And Promoting Featured Collections, Sherry Buchanan Dec 2022

Climate Justice And Racial And Gender Equity: Creating And Promoting Featured Collections, Sherry Buchanan

Library Faculty and Staff Publications and Presentations

PDXScholar, the repository for Portland State University, showcases three main collections that are automatically curated based on filters – tags that collect and display the content: Climate Justice, Racial and Gender Equity, and COVID-19. In this presentation, I will give an overview of our featured collections, their development and promotion, including the criteria for inclusion, technical aspects, and impact. The Digital Commons automated collection tool and system configuration will be briefly explained.


Differentiate Metasploit Framework Attacks From Others, Gina Liu Ajero Dec 2022

Differentiate Metasploit Framework Attacks From Others, Gina Liu Ajero

Electronic Theses and Dissertations

Metasploit Framework is a very popular collection of penetration testing tools. From auxiliaries such as network scanners and mappers to exploits and payloads, Metasploit Framework offers a plethera of apparatuses to implement all the stages of a penetration test. There are two versions: both a free open-source community version and a commercial professional version called Metasploit Pro. The free version, Metasploit Framework, is heavily used by cyber crimininals to carry out illegal activities to gain unauthorized access to targets.

In this paper, I conduct experiments in a virtual environment to discover whether attacks originated from Metasploit Framework are marked with …