Digital Commons Network^™

Receptor Tyrosine Kinase (Rtk) Targeting In Pediatric High-Grade Glioma And Diffuse Midline Glioma: Pre-Clinical Models And Precision Medicine., Kallen Schwark, Dana Messinger, Jessica R. Cummings, Joshua Bradin, Abed Kawakibi, Clarissa M. Babila, Samantha Lyons, Sunjong Ji, Rodrigo T. Cartaxo, Seongbae Kong, Evan Cantor, Carl Koschmann, Viveka Nand Yadav

Manuscripts, Articles, Book Chapters and Other Papers

Pediatric high-grade glioma (pHGG), including both diffuse midline glioma (DMG) and non-midline tumors, continues to be one of the deadliest oncologic diagnoses (both henceforth referred to as "pHGG"). Targeted therapy options aimed at key oncogenic receptor tyrosine kinase (RTK) drivers using small-molecule RTK inhibitors has been extensively studied, but the absence of proper in vivo modeling that recapitulate pHGG biology has historically been a research challenge. Thankfully, there have been many recent advances in animal modeling, including Cre-inducible transgenic models, as well as intra-uterine electroporation (IUE) models, which closely recapitulate the salient features of human pHGG tumors. Over 20% of …

Contraband, Omer Enes Demir

Theses

Contraband is a short fiction film about a young woman’s struggle to escape from a criminal life. As she is forced to smuggle drugs during prison visits to her husband, she must decide whether to protect him or abandon him. Leaving might give her a chance to save herself and her child from this life and have a better future. The movie takes place in modern-day Los Angeles. This paper describes and analyzes my filmmaking process as the writer and director of Contraband, and how my life experience and inspirations influenced my work.

Evaluating The Effects Of Thermal Cycling On Bone (Cold-Blooded Vs Warm-Blooded), Parker Reed Brewster

Electronic Theses and Dissertations

Thermal cycling, a global threat that is increasingly becoming more real, is a stressing event that can drastically change material properties. Thermal cycling can be used for material strengthening and optimization, but more often than that, thermal cycling is a nuisance that weakens the integrity of structures and coatings. To understand and build better designs that resist the effects of thermal cycling, we look to nature. Though warm-blooded animals regulate their body temperatures within an exceptionally tight range, cold-blooded animals experience relatively extreme temperature fluctuations, and oftentimes, in less than a 5-hour time period. In other words, cold-blooded animals experience …

Emotion Regulation In Migraine, Tracy Protti

Electronic Theses and Dissertations

Migraine is the third most common medical condition across the globe and a leading cause of years lived with disability due to its considerable burden. The burden is further compounded by the high prevalence of psychological comorbidities and the influence of other psychological factors on functioning. Examinations of migraine within the fear-avoidance model suggest that fear of pain (FOP) promotes maladaptive avoidance and escape behaviors, which contribute to headache-related disability. Limited research demonstrates that those with migraine engage in avoidant emotion-regulation (ER) strategies but has overlooked ER abilities beyond acceptance. The current study aimed to investigate ER in individuals with …

Cinema Studies, Burak Turten

University of South Florida (USF) M3 Publishing

PREFACE

Cinema Studies is a comprehensive book that, is hoped, will provide students and researchers with film studies and other persons interested in cinema with a useful reference book on film analysis and, where relevant, the different discussions surrounding that. The contributors analyze some films using ideas and concerns from modernism, cinematographic narrative, ideology, propaganda, migration, nomadism, and the sense of revenge. The book provides new insights into films and turns the discussion towards recent research questions and analyses, representing and constituting in each contribution new work in the discipline of film text analysis.

Therefore, each chapter of this book, …

Cinema Studies: Different Perspectives, Burak Turten

University of South Florida (USF) M3 Publishing

PREFACE

Cinema Studies: Different Perspectives is essential reading for anyone interested in cinema discipline. The singular aim of this edited book of scholarly text is to stimulate and engage readers in the fast-changing, complex, and increasingly interdisciplinary nature of cinema studies, and to serve as a catalyst for future intellectual, academic, and professional-driven research agendas. It is believed that the integration of cinema studies with other disciplines will undoubtedly contribute to the development of the cinema field both in practice and in theory.

Therefore, each chapter of this book, which consists of 9 chapters, focuses on a sub-discipline such as …

Experiences With Vitamin A In Copperbelt Province, Zambia, Topacio Ortiz

College of Education and Human Sciences: Dissertations, Theses, and Student Research

Vitamin A deficiency (VAD) is one of the most common micronutrient deficiencies in Sub-Saharan Africa. Zambians face high VAD rates, despite a mandate for fortified sugar and crops. Limited data have been collected from the most vulnerable segments of Zambia’s population; hence this study was designed as an initiatory study for future research to be conducted with primary school children and pregnant women in Zambian communities.

Once IRB approvals were obtained from the University of Nebraska-Lincoln (UNL) and the Copperbelt University School of Medicine, data were collected in Zambia’s Copperbelt Province, in the cities of Ndola and Luanshya, during May …

Nonbreeding Season Survival And Habitat Selection Of Northern Bobwhite In Northeastern Colorado, Joseph M. Wolske

School of Natural Resources: Dissertations, Theses, and Student Research

Northern bobwhites (Colinus virginianus) have experienced range-wide population declines. Recent harvest data from northeastern Colorado suggests bobwhite populations have declined and populations can be sensitive to adult nonbreeding season survival. We monitored 157 bobwhites in northeastern Colorado, on the northern periphery of the species’ range, for the 2019-2020 and 2020-2021 nonbreeding seasons to estimate nonbreeding season survival and habitat selection. We used known-fate survival models to assess any variation in survival between the winter stages of early-winter, mid-winter, and late-winter, as well as sex, age class, and mass at the time of capture. Survival varied among winter stages, …

Human Perception Of Exponentially Increasing Data Displayed On A Log Scale Evaluated Through Experimental Graphics Tasks, Emily Robinson

Department of Statistics: Dissertations, Theses, and Student Research

Log scales are often used to display data over several orders of magnitude within one graph. We conducted a series of three graphical studies to evaluate the impact displaying data on the log scale has on human perception of exponentially increasing trends compared to displaying data on the linear scale. Each study was related to a different graphical task, each requiring a different level of interaction and cognitive use of the data being presented. The first experiment evaluated whether our ability to perceptually notice differences in exponentially increasing trends is impacted by the choice of scale. Participants were shown a …

Creolization And Romanity: The Continuities And Changes Of Roman Egypt., Travis M. Kaelin

College of Arts & Sciences Senior Theses

Past scholarship has analyzed Roman Egypt through the process of Romanization, but my research evaluates the province through creolization instead. The process of creolization is complex but affords indigenous populations more agency than terms like romanization. The thesis addresses the Egyptian and Greek continuities in language, religion, and way of life to display the extent of creolization. Analysis of Roman Egypt through the post-colonial lens better represents the changes that took place and the intent of the Roman principate. Much of the research derives from papyrological and archaeological sources to create a more nuanced understanding of what Roman Egypt looked …

Meaning-Mating And Hyphenated Actualizing In Individual-Organization Units: Lived Experiences Of Organization Development Practitioners Learning And Carrying Out The Philosophy Of Organization Development, Brian Lee Chapman

Public Affairs Dissertations - Archive

Individuals have been organizing for millennia. The purpose of this study was to investigate what it means for individuals and organizations to each experience how an exposure to the instrumentalized philosophies of one impacts the internalized philosophies of the other. This phenomenological investigation focused on the lived experiences of Organization Development (OD) practitioners with learning and carrying out the philosophy of OD. Individual conversations with six participants during fourteen separate interview sessions were phenomenologically carried out, analyzed, and interpreted. The experiences articulated during these conversations elucidate two concepts not found during the literature review – meaning-mating and hyphenated actualization. These …

Using Portable X-Ray Fluorescence To Predict Physical And Chemical Properties Of California Soils, Micaela D. Frye

Master's Theses

Soil characterization provides the basic information necessary for understanding the physical, chemical, and biological properties of soils. Knowledge about soils can in turn be used to inform management practices, optimize agricultural operations, and ensure the continuation of ecosystem services provided by soils. However, current analytical standards for identifying each distinct property are costly and time-consuming. The optimization of laboratory grade technology for wide scale use is demonstrated by advances in a proximal soil sensing technique known as portable X-ray fluorescence spectrometry (pXRF). pXRF analyzers use high energy Xrays that interact with a sample to cause characteristic reflorescence that can be …

Archiving As The Foundation Of Fansubbing: A Case Study On Fan-Made Translation Of Virtual Youtubers In China, Jincai Jiang

Proceedings from the Document Academy

Although fansubbing has been increasingly recognised as a rich research spot for several disciplines like translation and media studies, the significance of fan archiving during fansubbing remains relatively less discussed despite its vitalness in 1) obtaining and managing both source and finalised products; 2) enabling fansubbing to evolve into systematic and efficient massive online practices. Based on the literature review of fansubbing’s historical development and the author’s observational fieldwork within an active Chinese fansubbing group, the paper explains why archiving can be the premise of fansubbing and demonstrates its latest application on Bilibili, arguably the most influential user-generated content sharing …

Addams’S Methodologies Of Writing, Thinking, And Activism, Marilyn Fischer

Books and Book Chapters by University of Dayton Faculty

To understand Addams’s texts, readers need to attend both to her evolutionary methodologies and to her interpretive strategies. Addams was an evolutionary scientist and sociologist in the days before natural selection became merged with genetics and before sociology adopted a stance of positivistic objectivity. Like other intellectuals at the nineteenth century’s turn, Addams addressed contemporary social problems by locating them within their evolutionary histories and proposing ways of moving society toward healthy equilibrium. She used specific social theories as tools, selecting the ones best suited for each given social problem. Evolutionary theorizing served as foundation and framing for her writings. …

A Script And Acting Analysis Of David Mamet’S Glengarry Glen Ross, Abdelrahman Metwally

Graduate Theses and Dissertations

Glengarry Glen Ross is a Pulitzer Prize-winning play by David Mamet. This paper is a practical guide for the actor to understanding the events of the play and, specifically, to approaching the role of Richard Roma, with a particular emphasis on Michael Chekhov’s psycho-physical work. First, I will discuss the circumstances, values and themes of the world of the play in relation to the character Shelley Levene as the main agent of the events. Then my focus in character analysis will shift to Richard Roma as the lead character of the ensemble. Together, the two characters create a contrasting duo …

Societal Sustainability: Projects To Address The Three Dimensions Of A Sustainable Future, Braden K. Bateman

Graduate Theses and Dissertations

Sustainability is an important, commonly discussed societal goal regarding assurance of resources for the world to be able to enjoy a prosperous future. Three primary dimensions of sustainability include environmental, economic, and social sustainability, and objectives for various projects can be aimed at any of the three dimensions to pursue societal sustainability. Solar installations, which can be used to pursue environmental and economic sustainability, convert abundant sunlight to electricity, displacing fossil fuel use that contributes harmful greenhouse gases to the atmosphere. The regulatory environment at the state level has a significant impact on the feasibility of solar projects. At present, …

Validation Of Whole Genome Resequencing For Mapping The Genetics Of Ascites In Broilers And Viral Susceptibility In Layers, Katherine Pepper Lee

Graduate Theses and Dissertations

This dissertation focused on the efficacy and validity of whole genome resequencing (WGR) for fine mapping genetic determinants of particular traits in a given organism. Previously, our research group used WGR to identify haplotype blocks of single nucleotide polymorphisms associated with ascites resistance with some as strong candidates for use in marker-assisted selection (MAS). Chapter 2 discusses the completion of a MAS project through evaluation of ascites incidence as well as production traits of economic value to poultry producers. Thus, the MAS project also covered viability of this methodology in the industry. The MAS significantly reduced ascites incidence in broilers …

Effects Of Ahcc On The Interaction Between T And B Lymphocytes, Sajina Poudel

Theses (2016-Present)

AHCC is a beta-glucan derived from the shiitake mushroom. It is used as an immune supplement and is known to boost the immune system. The mechanisms involved are increased lymphocyte proliferation and reduction of inflammation. The effects have been well studied in T cells. However, factors produced by T cells that affect B cells have not been studied. In this study, we explored the gene products stimulated by the AHCC exposure in T lymphocytes which play a role in B cell function. Data from a prior gene array experiment were used to delineate the effects of AHCC on the interaction …

An Overview Of The Extracurricular Polysaccaride Production Of Probiotic Lactic Acid Bacteria, Olujimi Babajide Olowokere

Theses (2016-Present)

The study focuses on a comprehensive review of lactic acid bacteria and their production of extracellular polysaccharide substrates (EPS). Two important factors are addressed in the work; and these are 1) identification of LAB stains found in the commercially sold daily milk, 2) significant factors impacting polysaccharide production. Motivation behind these focus points is to allow further inquiries and studies on exploring these strains of bacteria for human wellness promotion. With microbial EPS production being a recent interest of study among healthcare and food industries sectors, new species of bacteria are extensively exploited for further investigation to improve human health, …

Screening Tcf19 And Kif18b To Determine Co-Regulation With Mybl1 In Triple Negative Breast Cancer Patient Tissues, Tyra Sharda Ivory

Theses (2016-Present)

The aggressive behavior in triple-negative breast cancer (TNBC) is due to genetic signaling events, which call for the comprehensive analyses of genes differentially regulated in the cancers. Our laboratory previously found that MYBL1 was over-expressed in a fraction of the TNBC, compared to some luminal, and other breast cancer subtypes. The MYBL1 gene is a proto-oncogene that serves as a strong transcriptional activator. The gene is involved in signaling events related to cell cycle signaling, differentiation, proliferation, and apoptosis, all which are differentially regulated in cancers. Because MYBL1 is a transcription regulator, involved in cancer-related mechanisms and differentially expressed in …

Tau-Dependent Neurodegeneration And Alleviation By Etas®50, Clifford Tyree Castleberry

Theses (2016-Present)

Brain growth factors are a broad group of molecules that enable the brain to adapt to stress. In a study on Alzheimer’s mice (APP), we tested the role of an asparagus supplement, ETAS®50, to mitigate the stress caused by the Alzheimer’s condition in this mouse model. Gene expression data revealed regulation of genes related to neuronal growth and function, such as tau, which were severely stressed in the APP mice to be alleviated.

Mental Health In Engineering Education: Identifying Population And Intersectional Variation, Andrew Danowitz, Kacey Beddoes

Faculty Research, Scholarly, and Creative Activity

Contribution: Screening rates for engineering students for several major and moderate mental health issues are reported, including unspecified psychological distress as captured by the Kessler 6 screening instrument; screening rates for depressive, anxiety, and eating disorders as measured by the patient health questionnaire (PHQ); and screening rates for post-traumatic stress disorder (PTSD) as measured by the primary care post-traumatic stress disorder (PC-PTSD) instrument. This work also explores how mental health issues affect different student demographic groups within engineering. Background: Anecdotal evidence has long suggested that stress and certain mental health issues are particularly acute in the field of Engineering, and …

When Books Sing: The Musicalization Of Fiction And Intermediality In Craig Russell’S Fragment, Kathleen Collins

Electronic Theses, Projects, and Dissertations

Craig Russell’s novel Fragment merges a science fiction story of first contact between humans and whales and a chilling ecological disaster warning into one high action-adventure novel of the sea. Undergirding the novel and its many musical references is a rondo musical structure, manifested in the use of several geographical locations and a diverse group of character singers, both human and other. To uncover this, I will define and apply the contemporary theory of intermediality to the novel, and, along the way, expand the definition and consequences of the theory of intermediality. The result will be an ever-increasing interconnectedness to …

Early-Exercise Effects On Mice Tendon Remodeling, Miles Valencia

Electronic Theses, Projects, and Dissertations

Tendons connect and transmit energy between muscles and bones and play a key role in movement. Tendon remodels by breaking down and absorbing tendon components including collagen fibers and elastin while replacing them with newly formed tendon. These processes can be influenced by short- and long-term factors such as exercise and aging; the magnitude of influence on tendon remodeling remains unclear. I researched the effects of maturation and exercise on tendon remodeling using a mice colony artificially selected for high voluntary wheel running called high-runner mice. Control and high-runner linetype mice were separated into 2 age cohorts that started training …

How Groupy Is A Group?, Rohit J. Parikh

Publications and Research

Various Cooperating Groups

Why and how do they cooperate

Bees

Chinese troops

BLM demonstrators

The reasons are different in the three cases.

1) Bees cooperate because they are all sisters who have thesame DNA. From a purely evolutionary point of view the survival of one is the survival of all.

2) Chinese troops cooperate because they are obeying a single commander.

3) Black lives people cooperate because they have a single goal, and they have communicated to be together at one time and place.

The purpose of this work is to provide a definition of the "amount" of groupiness, revealed …

The Effect Of Increasing Intestinal Short‐Chain Fatty Acid Concentration On Gut Permeability And Liver Injury In The Context Of Liver Disease: A Systematic Review, Keith Pohl, Prebashan Moodley, Ashwin Dhanda

Peninsula Medical School

Background and AimThe gut barrier protects the liver through tight junctions, which are disrupted in liver disease either from dysbiosis, inflammation, or the effects of ingested compounds such as alcohol. Strengthening of the gut barrier may ameliorate liver injury of varying etiologies. Short chain fatty acids (SCFAs) have been shown to improve gut barrier function. This systematic review aims to synthesize all studies that have trialed SCFA supplementation as a therapy for liver disease.MethodsA systematic review assessing the impact of SCFA supplementation on liver injury and intestinal permeability was conducted. All forms of intervention that specifically increased intestinal SCFA concentration …

Ankle2-Related Microcephaly: A Variable Microcephaly Syndrome Resembling Zika Infection, Ajay X Thomas, Nichole Link, Laurie A Robak, Gail Demmler-Harrison, Emily C Pao, Audrey E Squire, Savannah Michels, Julie S Cohen, Anne Comi, Paolo Prontera, Alberto Verrotti Di Pianella, Giuseppe Di Cara, Livia Garavelli, Stefano Giuseppe Caraffi, Carlo Fusco, Roberta Zuntini, Kendall C Parks, Elliott H Sherr, Mais O Hashem, Sateesh Maddirevula, Fowzan S Alkuraya, Isphana A F Contractar, Jennifer E Neil, Christopher A Walsh, Hugo J Bellen, Hsiao-Tuan Chao, Robin D Clark, Ghayda M Mirzaa

Duncan NRI Faculty and Staff Publications

Objective: This study delineates the clinical and molecular spectrum of ANKLE2-related microcephaly (MIC), as well as highlights shared pathological mechanisms between ANKLE2 and the Zika virus.

Methods: We identified 12 individuals with MIC and variants in ANKLE2 with a broad range of features. Probands underwent thorough phenotypic evaluations, developmental assessments, and anthropometric measurements. Brain imaging studies were systematically reviewed for developmental abnormalities. We functionally interrogated a subset of identified ANKLE2 variants in Drosophila melanogaster.

Results: All individuals had MIC (z-score ≤ -3), including nine with congenital MIC. We identified a broad range of brain abnormalities including simplified cortical gyral pattern, …

Regional-Scale Climate-Induced Variation In Ant Physiology And Morphology, Daniel E. Murphy

Biology Theses

The biology of ectotherms such as insects is influenced by ambient thermal conditions. Ants are a ubiquitous and ecologically important group of insects and are well-established as bioindicators of thermal conditions. Ants are sensitive to the thermal extremes that vary with latitude, elevation, and land use, and these thermal gradients influence their spatial and temporal distributions. As a result, ants have evolved physiological and morphological thermal adaptations in response to the thermal environment of their habitats. These adaptations include increased physiological and morphological tolerance for temperature extremes. In Western New York (WNY), temperatures are temporally and spatially heterogeneous, changing with …

Summer 2022, Georgia Library Quarterly

Georgia Library Quarterly

No abstract provided.

Oconee County Library Puts On Inaugural Fanfest, Jessica Varsa

Georgia Library Quarterly

No abstract provided.