Digital Commons Network^™

In Vivo Characterization Of Glutamine Metabolism Identifies Therapeutic Targets In Clear Cell Renal Cell Carcinoma, Akash K Kaushik, Amy Tarangelo, Lindsey K Boroughs, Mukundan Ragavan, Yuanyuan Zhang, Cheng-Yang Wu, Xiangyi Li, Kristen Ahumada, Jui-Chung Chiang, Vanina T Tcheuyap, Faeze Saatchi, Quyen N Do, Cissy Yong, Tracy Rosales, Christina Stevens, Aparna D Rao, Brandon Faubert, Panayotis Pachnis, Lauren G Zacharias, Hieu Vu, Feng Cai, Thomas P Mathews, Giannicola Genovese, Barbara S Slusher, Payal Kapur, Xiankai Sun, Matthew Merritt, James Brugarolas, Ralph J Deberardinis

Faculty, Staff and Student Publications

Targeting metabolic vulnerabilities has been proposed as a therapeutic strategy in renal cell carcinoma (RCC). Here, we analyzed the metabolism of patient-derived xenografts (tumorgrafts) from diverse subtypes of RCC. Tumorgrafts from VHL-mutant clear cell RCC (ccRCC) retained metabolic features of human ccRCC and engaged in oxidative and reductive glutamine metabolism. Genetic silencing of isocitrate dehydrogenase-1 or isocitrate dehydrogenase-2 impaired reductive labeling of tricarboxylic acid (TCA) cycle intermediates in vivo and suppressed growth of tumors generated from tumorgraft-derived cells. Glutaminase inhibition reduced the contribution of glutamine to the TCA cycle and resulted in modest suppression of tumorgraft growth. Infusions with …

How Much Should Or Can Science Impact Theological Formulations? An AshʿArī Perspective On Theology Of Nature, Shoaib Ahmed Malik, Nazif Muhtaroglu

All Works

There have been many developments in the field of science and religion over the past few decades. One such development is referred to as ‘theology of nature’ (ToN), which is the activity of building or revising theological frameworks in light of cont...

Variation In The M-Opioid Receptor (Oprm1) And Offspring Sex Are Associated With Maternal Behavior In Rhesus Macaques (Macaca Mulatta), Zachary Baron

Theses and Dissertations

A m-opioid receptor (OPRM1) single-nucleotide-polymorphism, found in both humans and rhesus macaques mediates the mother-infant attachment bond. Because mothers treat their sons and daughters differently, it is somewhat surprising that the role of infant sex has not been assessed in the context of a maternal-OPRM1-genotype-by-infant-sex interaction. The present study investigates the effect of maternal-OPRM1-genotype and infant sex on mother-infant behaviors. Over the first six months of offspring life, mother-infant behavioral data assessing attachment quality was collected twice weekly from a large number of rhesus monkey mother-infant pairs (N=161 dyads; n=64 female infants, n=97 male infants). Mothers were genotyped for OPRM1 …

Polymeric Chloroquine In Metastatic Pancreatic Cancer Therapy, Rubayat Islam Khan

Theses & Dissertations

Hydroxychloroquine (HCQ) is an established drug that has been used for the treatment of multiple diseases, including malaria, rheumatoid arthritis, and lupus erythematosus. Several recently published studies have highlighted its beneficial use in various types of cancers, and a plethora of clinical trials are currently evaluating its use in cancer therapies, wherein some of the results look promising. The preclinical studies to date suggest HCQ can work effectively in conjunction with traditional cancer treatments, as it has been shown to sensitize tumor cells to a wide range of chemotherapeutic agents. Polymeric HCQ (PCQ), a macromolecular multivalent version of HCQ, has …

The Relationship Between P66shc Expression And Proliferation Of Human Prostate Cancer Cells With Mntnbuoe-2-Pyp Treatment, Thao Nhi Radik

Theses & Dissertations

Prostate cancer (PCa) is the second leading cause of cancer-related deaths in the U.S. in men, mainly due to the development of castration-resistant PCa (CRPC). MnTnBuOE-2-PyP⁵⁺ (BuOE), a superoxide dismutase (SOD) mimic, inhibits human PCa cell proliferation through hydrogen peroxide (H₂O₂). p66Shc protein level is upregulated in CRPC and is associated with cell proliferation in PCa cells.We propose that the different sensitivity of those PCa cells to BuOE could be due to the expression levels of p66Shc protein.

Our data showed that PCa cells that expressed high levels of p66Shc are more resistant to BuOE …

Analyzing The Effects Of Climate Impacts In El Salvador And How They Influence Pollution, Ecosystems And Communities, Veronica Norio-Tomasino

Master's Projects and Capstones

Due to projections of rising temperatures and increased frequency and severity of extreme weather events, the rate at which climate change is impacting nations is devastating. However, developing countries and vulnerable communities are not the primary contributors to climate change, but they are at a greater risk for climate impacts by industrialized nations. As a result of increased human activity, developing nations such as El Salvador are particularly susceptible to climate-related events. Deforestation, water pollution, and human health risks are some activities that have contributed to El Salvador's vulnerability to climate change, drastically affecting rural communities suffering from multidimensional poverty. …

Teaching English As A Foreign Language In China: A Unit Plan For Educators, Yun Xie

Master's Projects and Capstones

The ultimate goal of English learning is to enable students to communicate in English.

However, English education in China ignores the importance of English communicative ability. The problem lies in the teaching method, that is, solely adopting the Grammar Translation Method; the teaching model, only the “teacher-centered” teaching model is adopted for teaching, thus students do not have enough opportunities to practice spoken English; moreover, the teaching materials lack authenticity, practicality and content of target culture.

These three problems were explored as three themes in this field project and provided a unit plan on how to improve these problems. This …

Egfr Is A Master Switch Between Immunosuppressive And Immunoactive Tumor Microenvironment In Inflammatory Breast Cancer, Xiaoping Wang, Takashi Semba, Ganiraju C Manyam, Jing Wang, Shan Shao, Francois Bertucci, Pascal Finetti, Savitri Krishnamurthy, Lan Thi Hanh Phi, Troy Pearson, Steven J Van Laere, Jared K Burks, Evan N Cohen, James M Reuben, Fei Yang, Hu Min, Nicholas Navin, Van Ngu Trinh, Toshiaki Iwase, Harsh Batra, Yichao Shen, Xiang Zhang, Debu Tripathy, Naoto T Ueno

Faculty, Staff and Student Publications

Inflammatory breast cancer (IBC), the most aggressive breast cancer subtype, is driven by an immunosuppressive tumor microenvironment (TME). Current treatments for IBC have limited efficacy. In a clinical trial (NCT01036087), an anti-EGFR antibody combined with neoadjuvant chemotherapy produced the highest pathological complete response rate ever reported in patients with IBC having triple-negative receptor status. We determined the molecular and immunological mechanisms behind this superior clinical outcome. Using novel humanized IBC mouse models, we discovered that EGFR-targeted therapy remodels the IBC TME by increasing cytotoxic T cells and reducing immunosuppressive regulatory T cells and M2 macrophages. These changes were due to …

Mitochondrial Autophagy In Ischemic Aged Livers, Jae-Sung Kim, William C Chapman, Yiing Lin

2020-Current year OA Pubs

Mitochondrial autophagy (mitophagy) is a central catabolic event for mitochondrial quality control. Defective or insufficient mitophagy, thus, can result in mitochondrial dysfunction, and ultimately cell death. There is a strong causal relationship between ischemia/reperfusion (I/R) injury and mitochondrial dysfunction following liver resection and transplantation. Compared to young patients, elderly patients poorly tolerate I/R injury. Accumulation of abnormal mitochondria after I/R is more prominent in aged livers than in young counterparts. This review highlights how altered autophagy is mechanistically involved in age-dependent hypersensitivity to reperfusion injury.

Evaluation Of Mtorc1 Signaling In Mouse Atherosclerotic Macrophages By Flow Cytometry And Immunofluorescence, Xiangyu Zhang, Jeremiah Stitham, Astrid Rodriguez-Velez, Se-Jin Jeong, Arick Park, Yu-Sheng Yeh, Divya Kapoor, Bettina Mittendorfer, Babak Razani

2020-Current year OA Pubs

Previous studies have demonstrated that a high-protein diet leads to increased atherosclerosis in mice, and that this adverse effect is caused by activation of macrophage mTORC1 signaling. Here, we provide a detailed protocol for the evaluation of diet-induced mTORC1 signaling in plaque macrophages in atherosclerosis-prone apolipoprotein E (ApoE) knockout (KO) mice. This protocol includes flow cytometry and immunofluorescence analysis of atherosclerotic macrophages that can be used to study the atherogenic potential of a variety of mTORC1 modulators. For complete details on the use and execution of this protocol, please refer to Zhang et al. (2020).

Texas, Melissa Munson

Oil and Gas, Natural Resources, and Energy Journal

No abstract provided.

Kentucky, Gary Holland

Oil and Gas, Natural Resources, and Energy Journal

No abstract provided.

Timeless Lessons About Leadership From The Midrash, Hershey H. Friedman

The Journal of Values-Based Leadership

This paper examines two ancient Midrashim and shows that many important messages about leadership are embedded in them. The first Midrash describes the critical personality trait Moses possessed that made him uniquely suitable to be a leader of the Israelites — compassion. The second Midrash appears heretical since it has Moses correcting God. Indeed, God even openly admits, "You have taught me something." The primary lessons are that leaders must be compassionate, humble, willing to listen to advice, eager to make changes when necessary, and admit to mistakes.

Monkeypox: Facts For Faith Community Nurses, Melissa K. Travelsted

International Journal of Faith Community Nursing

Faith community nurses provide services to diverse populations and should be aware of the recent monkeypox outbreak. The 2022 outbreak is dissimilar from previous as cases are occurring in non-endemic countries with no travel connections to endemic countries. Cases in the United States are mostly identified in the gay, bisexual, and other men who have sex with men. Symptoms of monkeypox begin with flu-like symptoms progressing to a sequential rash (macule, papule, vesicles, pustules, scabs). The distinguishing characteristic of monkeypox from other Orthopoxviruses is lymphadenopathy. There is no FDA approved treatment for monkeypox as most cases are mild and self-limiting, …

Strengthening Adolescent Reproductive Health As A Strategy To Diminish Maternal Mortality: A Case Study In Malang, Keppi Sukesi

Journal of International Women's Studies

The aims of this study are: (1) describing adolescent knowledge and understanding of reproductive health, (2) describing gender issues related to adolescent reproductive health, (3) describing delayed medical assistance due to socio-cultural aspects resulting in the death of the mother, and (4) strengthening adolescent awareness of reproductive health as a strategy to decrease maternal mortality. Based on a qualitative approach with a case study design, the research was conducted at Malang Regency using the snowball method, and a survey on adolescent understanding of reproduction was conducted in Singosari and Pujon. Results demonstrated that adolescent knowledge of reproductive health is relatively …

Working Paper Part 1 : The Very First Pilgrimage - An Inspired Trajectory Out Of Africa, Ian S. Mcintosh

International Journal of Religious Tourism and Pilgrimage

One hundred thousand years ago, give or take, the forebears of some of Australia’s First Nations—by some accounts as few as 150 people—left Africa on an immense journey. After some 2,000 generations, the passage through new and unfamiliar territories of these first modern human beings terminated in a supercontinent that included Australia, Papua, and Tasmania. By some estimates, no more than 150 people—the same number that had originally left Africa—made the final sea crossing that separates Indonesia and Australia. Research on such ancient migrations emphasises population growth, the ‘selfish gene,’ and the territorial imperative, as key drivers of mobility. This …

Making History Visible: Ireland’S National Famine Way Told Through Models And Interactive Digital Narratives, E. Moore Quinn

International Journal of Religious Tourism and Pilgrimage

The National Famine Way is a trail along Ireland’s Royal Canal that traces the remarkable trek of the 1,490 tenants who were evicted by their landlord, Denis Mahon, from his estate in Strokestown, County Roscommon, in the Republic of Ireland, during ‘Black ’47,’ the worst year of the Great Irish Famine (Irish: An Gorta Mór, the Great Hunger of 1847). The evictees were ‘escorted’ from their homes to vessels that awaited them in Dublin. They were then taken to Liverpool, where they were placed on four so-called ‘coffin ships’ bound for Canada. The path along the Royal Canal is 165 …

Roles Of Religious Guides In Tourism: A Qualitative Study From Japan, Ricardo Nicolas Progano

International Journal of Religious Tourism and Pilgrimage

Pilgrimage travel has become an important element in contemporary tourism, as visitors flock to sacred locations (UNWTO, 2015). However, some aspects of pilgrimage travel remain relatively understudied, with one of them being the roles of guides in these locations. Based on previous academic works, the present study aims to bridge this gap by analysing the role of religious figures who engage in guiding activities aimed at the general public. For this, Shippōryū-ji, a Shugendō temple located in Japan, is presented as the case study. As previous research on the subject is scarce, a qualitative approach was deemed suitable. Utilising interview …

From Palma To Lluc – The Social And Organisational Life Of A Nocturnal Pilgrimage In Mallorca, Maja Balle

International Journal of Religious Tourism and Pilgrimage

Although the island of Mallorca is well known for its beaches and mass tourism sector, a local pilgrimage tradition with deep roots in Catholicism is still thriving on the island; on the first weekend in August, thousands of people gather to make a nocturnal pilgrimage to a shrine at Lluc Mountain. Rather than focusing on the actual performance of the sacred journey or the culmination of its ritualised accomplishment, this case study explores the social and economic framing of the event orchestrated by actors from the local community, the church, the governmental sector, and other private and public stakeholders. The …

Southern Adventist University Commencement Program December 2022, Southern Adventist University

Commencement Programs

Program for Southern Adventist University Fall 2022 graduation. The commencement service took place on December 15, 2022, at 7pm in Iles P.E. Center.

Medical School Watercooler Newsletter - December 15, 2022, Lindsey Lyle

Watercooler Newsletter

This is the December 15, 2022 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents include:

• Sickle Cell Center leadership changes announced
• Center for Healthy Communities hosts first professional development forum
• Create a page in our 50th anniversary book
• Meet a Med Student: Yulong Huang
• USA grieves loss of Professor Emeritus Frank S.Pettyjohn, M.D.
• USA scientists win NIH grant to study ticks, leprosy

Issue 409: December 15-January 19, 2022, The Local Voice

The Local Voice

No abstract provided.

Socio‑Economic Inequalities In Minimum Dietary Diversity Among Bangladeshi Children Aged 6–23 Months: A Decomposition Analysis, Satyajit Kundu, Pranta Das, Ashfikur Rahman, Hasan Al Banna, Kaniz Fatema, Akhtarul Islam, Shobhit Srivastava, T. Muhammad, Rakhi Dey, Ahmed Hossain

Department of Statistics: Faculty Publications

This study aimed to measure the socio-economic inequalities in having minimum dietary diversity (MDD) among Bangladeshi children aged 6–23 months as well as to determine the factors that potentially contribute to the inequity. The Bangladesh Demographic and Health Survey (BDHS) 2017–2018 data were used in this study. A sample of 2405 (weighted) children aged 6–23 months was included. The overall weighted prevalence of MDD was 37.47%. The concentration index (CIX) value for inequalities in MDD due to wealth status was positive and the concentration curve lay below the line of equality (CIX: 0.1211, p < 0.001), where 49.47% inequality was contributed by wealth status, 25.06% contributed by the education level of mother, and 20.41% contributed by the number of ante-natal care (ANC) visits. Similarly, the CIX value due to the education level of mothers was also positive and the concentration curve lay below the line of equality (CIX: 0.1341, p < 0.001), where 52.68% inequality was contributed by the education level of mother, 18.07% contributed by wealth status, and 14.69% contributed by the number of ANC visits. MDD was higher among higher socioeconomic status (SES) groups. Appropriate intervention design should prioritize minimizing socioeconomic inequities in MDD, especially targeting the contributing factors of these inequities.

Full Issue: Fall 2022

DePaul Magazine

In the fall 2022 issue of DePaul Magazine, we share how DePaul President Robert L. Manuel is inspiring and invigorating the university community. As Manuel says in our cover story, DePaul is uniquely situated to use its Catholic, Vincentian mission to address the most pressing questions facing our society today. We also look at service, including university initiatives to reach out to underserved and displaced populations, as well as programs that pair DePaul students with industry and community clients, giving students valuable experience and connections.

Evaluating The Effects Of Cannabis Use On Fertility And Artificial Reproductive Technology, Iridiana Hermenegildo, Timothy Aylward, Justin Gambini

Doctor of Medical Science (DMSc)

Background: Cannabis is widely used among males and females of reproductive age. A growing body of research suggests the endocannabinoid system is negatively impacted by the use of cannabis affecting many factors required for fertility. Objective: This article aims to evaluate existing literature on trends seen in patients undergoing artificial reproductive therapy (ART) and the effects cannabis has on fertility outcomes, including conception. Methods: This is a systematic review searching PubMed, MEDLINE, and Academic Search Premier databases through August 2022 using keywords derived from three defined concepts. Articles were then evaluated for relevance and included if meeting criteria. Results: …

The Evolutionary Dynamics Of Infectious Diseases On An Unstable Planet: Insights From Modeling The Stockholm Paradigm, Angie T. C. Souza, Sabrina B. L. Araujo, Walter A. Boeger

MANTER: Journal of Parasite Biodiversity

Emerging infectious diseases (EIDs) are, besides a question of food safety and public health, an ecological and evolutionary issue. The recognition of this condition combined with the accumulation of evidence that pathogens are not specialists in their original hosts evidences the need for understanding how the dynamics of interaction between pathogens and hosts occurs. The Stockholm Paradigm (SP) provides the theoretical fundaments to understand the dynamics of diseases and design proactive measures to avoid the emergence and reemergence of infectious diseases. In this review, we revisit the models that evaluate several aspects of the proposed dynamics of the SP, including …

Peat And Patty: Providing A Voice For Nature Through Animation, Clinnie Brinson

Electronic Theses and Dissertations, 2020-2023

Peat and Patty is a 3D animated short story of a young scientist, Patty, and her pet parrot Peat, whose goal is to save their world from a dying ecosystem. Ultimately, they inadvertently receive help from a nearby polar bear which leads to the success of Patty's experiment. The purpose of this story is to highlight the dangers of global warming to our own ecosystem thus building eco-consciousness in viewers. We currently have natural disasters increasing in frequency, a rising global temperature, and pollution in our bodies of water (Rossati). By personifying nature, animation can invoke empathy from viewers towards …

The Y-Chromosome's Role In Sexually Dimorphic Evolution And Mother's Curse Compensation, Tobias Nielsen

Electronic Theses and Dissertations, 2020-2023

The Y-chromosome and mitochondria (containing mtDNA) appear entirely dissimilar, the former being a sex chromosome found in the nucleus and the latter an organelle with thousands of copies in the cytoplasm. However, both experience uniparental inheritance, with Y-chromosomes being patrilineal and mitochondria matrilineal. This leads to various other similarities including haploidy, high mutation rates, and limited or lack of genetic recombination. Moreover, the low number of protein-coding genes contained on both led to the belief that neither contributes significantly to the adaptive evolution of complex traits. However, recent studies show the Y-chromosome and mitochondria both influence roughly 10% of male …

Quantifying Volatile Fatty Acid Concentrations During The Pretreatment And Anaerobic Digestion Process, Sascha Boutelle

Theses and Dissertations

Producing renewable energy from biomass or from the wastewater treatment process has gained momentum in the past 20 years. Anaerobic digestion has historically been used as one step in the waste treatment process, to both reduce the mass of waste that needs to be disposed of and to generate biogas. This process is typically only able to reduce 30-40% of the waste mass because of the recalcitrant nature of the waste streams being treated. Anaerobic pretreatment with the thermophilic bacteria Caldicellulosiruptor bescii (C. bescii) has been proven to increase the percentage of mass digested and consequently increase methane production to …

Southeast Asia & The Hidden Green Revolution: A Study On Foreign Direct Investment In Eco-Investments In Asean, Ravi Chailertborisuth

Undergraduate Honors Theses

This paper aims to find: To what extent foreign direct investment is fueling the renewable energy transition in ASEAN. The year 1966 saw the founding of ASEAN, the Association for Southeast Asian Nations. The five founding member nations were: Indonesia, Malaysia, Philippines, Singapore, and Thailand. Over time, this group of nations grew to include nations such as: Laos, Cambodia, Vietnam, Brunei, and Myanmar. The IGO (inter-governmental organization) aims to foster “economic, social, cultural, technical, educational and other fields” (ASEAN). The IGO is successful, allowing capital to flow cross-borders with more ease, and encourage economic corporation across all nations. Since …