Digital Commons Network^™

The Meaning Of Excess In A Dutch Maenad Painting, Rebecca R. Kaczmarek

Parnassus: Classical Journal

No abstract provided.

Lavinia: The Weaver And The Mother Wolf, Anne-Catherine Schaaf

Parnassus: Classical Journal

No abstract provided.

Strengthening The Radiometric Link To The Si: Achievements From The Chipscale Project, Marit Ulset Nordsveen, Jarle Gran

The Characterization and Radiometric Calibration for Remote Sensing Annual Meeting (CALCON)

The EURAMET European Metrology Programme for Innovation and Research (EMPIR) project chipS·CALe aims to improve and simplify radiometric traceability with a focus on strengthening the link between radiometric measurements and the international system of units (SI). In this project, several national metrology institutes (NMIs) and research institutions in Europe have collaborated to develop improved low-loss Predictable Quantum Efficient Detector (PQED) photodiodes with an external quantum deficiency in the 10 ppm range or below from 400 nm to 850 nm.

These induced-junction photodiodes are simple in their structure, making them suitable for 3D computer simulations. In a 2 minute animation video …

Diallyl Disulfide Inhibits Proliferation, Epithelial—Mesenchymal Transition, And Invasion Through Rorα-Mediated Downregulation Of Wnt1/Β-Catenin Pathway In Gastric Cancer Cells, Jian Su, Hui He, Yu-Kun Li, Hong Xia, Fang Liu, Ying Zeng, Xi Zeng, Hui Ling, Bo Su, Qi Su

Journal of Food and Drug Analysis

Overactivation of Wnt/β-catenin pathway due to dysfunction of retinoid-related orphan receptor α (RORα) is related to cancer development and progression. Diallyl disulfide (DADS), an active component of garlic, has been reported in our previous study for upregulation of RORα expression in gastric cancer (GC) cells. It remains to be elucidated the role and mechanism of RORα in DADS against GC. This study revealed that DADS treatment resulted in reduced expression levels of Wnt1, β-catenin, TCF-4, intranuclear β-catenin and p-β-catenin in GC cells, concomitant with the compromised expression of β-catenin target genes (Axin, c-Jun, and c-Myc). RORα overexpression augmented DADS-induced downregulation …

Melatonin Exerts Anti-Fibrinolytic Effects By Regulating Il-1Β-Induced Changes In Upa, Upar, And Pai-1 Expression/Production In Human Dental Pulp Cells, Mei-Chi Chang, Bor-Hao Zhong, Hui-Na Lee, Fu-Hsiung Chuang, Ming-Shu Lee, Hsiao-Hua Chang, Yu-Hwa Pan, Jiiang-Huei Jeng

Journal of Food and Drug Analysis

Interleukin-1b (IL-1β) is a pro-inflammatory cytokine and its expression is increased in inflamed dental pulp. IL-1β affects plasminogen activation system molecules, which are crucial for tissue inflammation, fibrinolysis, matrix turnover, and cell adhesion and migration. Melatonin, which provides circadian and seasonal signals, is a physiological endocrine generated by the pineal gland. It has anti-oxidant and anti-inflammatory properties. Studies are warranted to determine whether melatonin prevents IL-1β-induced expression/production of plasminogen system molecules. Human dental pulp cells (HDPCs) were exposed to IL-1β or melatonin alone or to IL-1β with/without pretreatment with melatonin or other inhibitors. The mRNA expression of uPA, uPAR, and …

Quantification Of Anthocyanosides In Grapes By Quechers And Biphenyl-Uhplc Tandem Mass Spectrometry, Lun-Chi Yang, Sung-Fang Chen

Journal of Food and Drug Analysis

In this study, the QuEChERS and UHPLC-MS/MS method using a biphenyl stationary phase was developed and applied for the rapid separation of 12 anthocyanosides in grapes. Efficient separation was achieved for a wide range of mono- and un-glycosylated anthocyanosides. The linear ranges of the target anthocyanosides were 0.5 to 500 ng mL⁻¹. The intra- and inter-day precisions were both below 11.8%. Anthocyanosides in grapes from different sources were successfully quantified. Thus, the developed QuEChERS and UHPLC-MS/MS method provide an attractive alternative for the quantification of anthocyanosides in grapes.

Fluorescence Detection Of Malachite Green In Fish Based On Aptamer And Sybr Green I, Jia Wang, Chengyi Hong, Zhengzhong Lin, Zhi-Yong Huang

Journal of Food and Drug Analysis

A simple fluorescence method to quantitatively monitor malachite green (MG) was introduced based on the conformation switch effect of MG-aptamer (Apt) and the fluorochrome of SYBR Green I (SGI). SGI can embed in the stem–loop structure of Apt to produce fluorescence. However, the fluorescence will be quenched when MG is introduced because of the specific binding of Apt to MG. Under the optimal conditions, the fluorescence method displayed excellent linear relationship between the fluorescence quenching efficiencies and the MG concentrations ranging from 0.02 μmol L⁻¹ to 1.0 μmol L⁻¹. The detection limit of the method was 0.67 …

Bromelain Activates The Amp-Activated Protein Kinase-Autophagy Pathway To Alleviate Hepatic Lipid Accumulation, Po-An Hu, Man-Chen Hsu, Szu-Han Chen, Chia-Hui Chen, Yu Ru Kou, Jenq-Wen Huang, Tzong-Shyuan Lee

Journal of Food and Drug Analysis

Bromelain, a cysteine protease found in pineapple, is known to exert protective effects against non-alcoholic fatty liver disease (NAFLD); however, the underlying mechanism is unclear. In this study, we aimed to investigate the molecular mechanisms underlying the beneficial effects of bromelain using in vivo and in vitro models. C57BL/6 mice were fed a high-fat diet (HFD) with or without bromelain (20 mg/kg/day) for 12 weeks. We found that treatment with bromelain alleviated hepatic lipid accumulation accompanied by the activation of AMP-activated protein kinase (AMPK) and autophagy flux, as evidenced by the elevated levels of phosphorylated AMPK, ATG5, ATG7, LC3-II, and …

Metabolism-Involved Drug Interactions With Traditional Chinese Medicines In Cardiovascular Diseases, Ren-Jong Liang, Shu-Hao Hsu, Tien-Yu Chang, Tzu-Yi Chiang, Hong-Jaan Wang, Yune-Fang Ueng

Journal of Food and Drug Analysis

Herbal medicines have been widely used for the past millennia. Traditional Chinese medicine (TCM) is a major modality in Chinese medical care and has garnered global attention owing to its pharmacological effects and multi-targeted actions. The increased incidence of sequential or concurrent use of herbs and drugs in patients forces us to consider herb-drug interactions (HDIs) in this modern era. One of the main causes of HDIs is modulation of drug metabolism, in which cytochrome P450 (CYP), UDP-glucuronosyltransferase (UGT), and transporters play primary roles. In this review, we focus on in vivo studies of HDIs, particularly in the treatment of …

Epigenetic Activation Of The Flt3 Gene By Znf384 Fusion Confers A Therapeutic Susceptibility In Acute Lymphoblastic Leukemia., Xujie Zhao, Ping Wang, Jonathan D Diedrich, Brandon Smart, Noemi Reyes, Satoshi Yoshimura, Jingliao Zhang, Wentao Yang, Kelly Barnett, Beisi Xu, Zhenhua Li, Xin Huang, Jiyang Yu, Kristine Crews, Allen Eng Juh Yeoh, Marina Konopleva, Chia-Lin Wei, Ching-Hon Pui, Daniel Savic, Jun J Yang

Faculty Research 2022

FLT3 is an attractive therapeutic target in acute lymphoblastic leukemia (ALL) but the mechanism for its activation in this cancer is incompletely understood. Profiling global gene expression in large ALL cohorts, we identify over-expression of FLT3 in ZNF384-rearranged ALL, consistently across cases harboring different fusion partners with ZNF384. Mechanistically, we discover an intergenic enhancer element at the FLT3 locus that is exclusively activated in ZNF384-rearranged ALL, with the enhancer-promoter looping directly mediated by the fusion protein. There is also a global enrichment of active enhancers within ZNF384 binding sites across the genome in ZNF384-rearranged ALL cells. Downregulation of ZNF384 blunts …

How Servant Leaders Navigate Conflict: An Analysis Of Acts 15:36–41, Joshua D. Henson, Justin R. Craun

Selected Faculty Publications

Greenleaf’s foundational work on servant leadership has evolved considerably over the past 50 years. Servant leadership has been found to have positive outcomes on group and organisational effectiveness. While servant leadership characteristics and outcomes have been measured, is a need to be better understand how servant leaders navigate when they disagree. Using a social and cultural analysis, the conflict between Paul and Barnabas is explored. Social and cultural analysis allows interpreters to understand what the characters in the narrative ‘see and hear.’ The analysis of Acts 15:36–41 yielded three emerging themes related to how these servant leaders navigated conflict: (1) …

Assessment Of E-Learning Methods In The Digital Design Studio For Architectural Design Course During Corona Crisis Case Study The Architecture Department At Phi-Egypt, Walaa Hussein

Mansoura Engineering Journal

Corona pandemic forced education systems in the world to turn to distance learning via the Internet this study covered the period from March 2020 to the first semester of the academic year 2020/2021, which was performed by a hybrid system (face-to-face + online). Then studying its returns in the following year at the level of students and the method of teaching. Then integrating new mechanisms by questionnaire through an intended sample of three groups of students in the first, final, and pre-final courses for Architectural Design courses 2, 3, 6 and 7, as well as the graduation project course and …

The Parthenon, September 14, 2022, Tyler Spence, Connor Woodruff, Evan Green, Shauntelle Thompson, Chayce Matheny, Victoria Ware, Rafael Alfonso, Abby Hanlon, Alaina Laster

The Parthenon

No abstract provided.

Daily Eastern News: September 14, 2022, Eastern Illinois University

September

No abstract provided.

September 14, 2022 (Vol. 107, No. 4), Daily Eastern News

Daily Eastern News: 2022-2023

No abstract provided.

Development And Characterization Of Type I Interferon Receptor Knockout Sheep: A Model For Viral Immunology And Reproductive Signaling, Christopher J. Davies, Zhiqiang Fan, Kira P. Morgado, Ying Liu, Misha Regouski, Qinggang Meng, Aaron J. Thomas, Sang-Im Yun, Byung-Hak Song, Jordan C. Frank, Iuri V. Perisse, Arnaud Van Wettere, Young-Min Lee, Irina A. Polejaeva

Animal, Dairy, and Veterinary Science Faculty Publications

Type I interferons (IFNs) initiate immune responses to viral infections. Their effects are mediated by the type I IFN receptor, IFNAR, comprised of two subunits: IFNAR1 and IFNAR2. One or both chains of the sheep IFNAR were disrupted in fetal fibroblast lines using CRISPR/Cas9 and 12 lambs were produced by somatic cell nuclear transfer (SCNT). Quantitative reverse transcription-polymerase chain reaction for IFN-stimulated gene expression showed that IFNAR deficient sheep fail to respond to IFN-alpha. Furthermore, fibroblast cells from an IFNAR2^−/− fetus supported significantly higher levels of Zika virus (ZIKV) replication than wild-type fetal fibroblast cells. Although many lambs have …

The Lumberjack, September 14, 2022

Cal Poly Humboldt's Student Newspaper

The student newspaper of Humboldt State University.

Novel Technologies To Characterize And Engineer The Microbiome In Inflammatory Bowel Disease, Alba Boix-Amorós, Hilarly Monaco, Elisa Sambataro, Jose C. Clemente

Publications and Research

We present an overview of recent experimental and computational advances in technology used to characterize the microbiome, with a focus on how these developments improve our understanding of inflammatory bowel disease (IBD). Specifically, we present studies that make use of flow cytometry and metabolomics assays to provide a functional characterization of microbial communities. We also describe computational methods for strain-level resolution, temporal series, myco - biome and virome data, co-occurrence networks, and compositional data analysis. In addition, we review novel techniques to therapeutically manipulate the microbiome in IBD. We discuss the benefits and drawbacks of these technologies to increase awareness …

Spatially Guided Construction Of Multilayered Epidermal Models Recapturing Structural Hierarchy And Cell–Cell Junctions, Haiwei Zhai, Xiaowei Jin, Grayson Minnick, Jordan Rosenbohm, Mohammed Abdul Haleem Hafiz, Ruiguo Yang, Fanben Meng

Department of Mechanical and Materials Engineering: Faculty Publications

A current challenge in 3D bioprinting of skin equivalents is to recreate the distinct basal and suprabasal layers and promote their direct interactions. Such a structural arrangement is essential to establish 3D stratified epidermis disease models, such as for the autoimmune skin disease pemphigus vulgaris (PV), which targets the cell– cell junctions at the interface of the basal and suprabasal layers. Inspired by epithelial regeneration in wound healing, a method that combines 3D bioprinting and spatially guided self-reorganization of keratinocytes is developed to recapture the fine structural hierarchy that lies in the deep layers of the epidermis.Herein, keratinocyteladen fibrin hydrogels …

Impairment Of Igg Fc Functions Promotes Tumor Progression And Suppresses Nk Cell Antitumor Actions, Xuejun Fan, Zihao Yuan, Yueshui Zhao, Wei Xiong, Hao-Ching Hsiao, Rahmawati Pare, Jianmin Ding, Ahmad Almosa, Kai Sun, Songlin Zhang, Robert E Jordan, Cheok Song Lee, Zhiqiang An, Ningyan Zhang

Faculty, Staff and Student Publications

Natural killer (NK) cells mediate antibody dependent cytotoxic killing of cancer cells via cross-linking FcγR on NK cells with IgG-Fc. Studies have shown that the single-hinge cleaved IgGs (scIgGs) have dysfunctional Fc and failed engagement with FcγRs on immune cells. However, little is known about how scIgGs impact on antitumor immunity in the tumor microenvironment. In this study, we revealed a significant association of tumor scIgGs with tumor progression and poor outcomes of breast cancer patients (n = 547). Using multiple mouse tumor models, we demonstrated that tumor scIgGs reduced NK cell cytotoxic activities and resulted in aggressive tumor progression. …

Identification Of Risk Genes For Alzheimer’S Disease By Gene Embedding, Yashwanth Lagisetty, Thomas Bourquard, Ismael Al-Ramahi, Carl Grant Mangleburg, Samantha Mota, Shirin Soleimani, Joshua M Shulman, Juan Botas, Kwanghyuk Lee, Olivier Lichtarge

Duncan NRI Faculty and Staff Publications

Most disease-gene association methods do not account for gene-gene interactions, even though these play a crucial role in complex, polygenic diseases like Alzheimer’s disease (AD). To discover new genes whose interactions may contribute to pathology, we introduce GeneEMBED. This approach compares the functional perturbations induced in gene interaction network neighborhoods by coding variants from disease versus healthy subjects. In two independent AD cohorts of 5,169 exomes and 969 genomes, GeneEMBED identified novel candidates. These genes were differentially expressed in post mortem AD brains and modulated neurological phenotypes in mice. Four that were differentially overexpressed and modified neurodegeneration in vivo are …

The Effects Of Animal- Assisted Therapy On The Health And Well- Being Of Military Veterans: A Systematic Scoping Review And Recommendations For Future Research, Brooke Fonseka, Fiona Marshall, Laura J. Edwards

People and Animals: The International Journal of Research and Practice

Veterans of the armed forces may have experienced a range of physical and psychological traumas during their service, which can lead to long-standing problems with health and well-being, sometimes compounded with challenges accessing and engaging with support. Animal-assisted therapies (AAT) may offer an engaging, holistic approach that could be helpful for the veteran population. The aim of this scoping review is to examine the existing research on the effects of AAT on the health and well-being of veterans.

Method: The databases EMBASE (OVID), Web of Science, Cinahl, Cochrane and Medline were searched in October 2020. Articles were screened against inclusion …

Farmyard Animal Or Best Friend? Exploring Predictors Of Dog Vs. Pig Pet Speciesism, Sarah Gradidge, Magdalena Zawisza, Annelie J. Harvey, Daragh T. Mcdermott

People and Animals: The International Journal of Research and Practice

Despite dogs’ and pigs’ shared similarities, previous research indicates people favor dogs over pigs (known as “pet speciesism”). While pet speciesism has been empirically sup-ported, little is known about its predictors. This gap in the literature is problematic as urgent requirements to decrease meat consumption emphasize the pressing need to develop interventions to reduce pet speciesism and thus reduce meat consumption. However, to develop these interventions, we must first identify why people view pigs (vs. dogs) negatively. To begin addressing this gap, the current study utilized the stereotype content model to uniquely explore pet speciesism’s predictors. We recruited participants via …

Making The Case: Adding A Social Work Perspective To A Case Study In A Veterinary Practice, Paula Gerstenblatt, Diane Rhodes, Dorothea Ivey

People and Animals: The International Journal of Research and Practice

This article describes a case study exploration of a veterinary practice from the perspective of social work. Recognizing the stressful work of veterinary providers, including compassion fatigue and high suicide rates, the current study identified both a need for and the potential role of social workers in veterinary practice. Professionals were interviewed in an emergency/specialty practice. Using the interview data, the authors built a demonstrative case that underlines the vulnerability of veterinary professionals and the potential of social work to improve the quality of their work experiences and longevity.

Recent Findings On Phosphorus Digestibility Of Feed Ingredients In Broilers, Jay Hampton, Wenting Li, Franco Mussini, Katie Hilton, Janet Remus, Samuel J. Rochell

Proceedings of the Arkansas Nutrition Conference

Accurately meeting the dietary P needs of broilers is critical to ensure optimal bird performance, health, and welfare without causing undue environmental burdens associated with excess dietary P excretion. Phosphorus is commonly supplied in broiler diets from inorganic phosphates derived from non-renewable sources, but it has been estimated that peak P production will occur between 2030-2040 and that the global supply of P could be depleted within this century (Cordell and Drangert, 2009; Nest and Cordell, 2012). To address these concerns, inorganic P use in agriculture, including use in broiler diet formulation, requires careful stewardship. To this end, the dietary …

Pulse-Echo Quantitative Us Biomarkers For Liver Steatosis: Toward Technical Standardization, Timothy Stiles, David T. Fetzer, Ivan M. Rosado-Mendez, Michael Wang, Michelle L. Robbin, Arinc Ozturk, Keith A. Wear, Juvenal Ormachea, J. Brian Fowlkes, Timothy J. Hall, Anthony E. Samir

Natural Sciences Publications

Excessive liver fat (steatosis) is now the most common cause of chronic liver disease worldwide and is an independent risk factor for cirrhosis and associated complications. Accurate and clinically useful diagnosis, risk stratification, prognostication, and therapy monitoring require accurate and reliable biomarker measurement at acceptable cost. This article describes a joint effort by the American Institute of Ultrasound in Medicine (AIUM) and the RSNA Quantitative Imaging Biomarkers Alliance (QIBA) to develop standards for clinical and technical validation of quantitative biomarkers for liver steatosis. The AIUM Liver Fat Quantification Task Force provides clinical guidance, while the RSNA QIBA Pulse-Echo Quantitative Ultrasound …

Apolipoprotein E4 Impairs The Response Of Neurodegenerative Retinal Microglia And Prevents Neuronal Loss In Glaucoma, Milica A. Margeta, Zhuoran Yin, Charlotte Madore, Kristen M. Pitts, Sophia M. Letcher, Jing Tang, Shuhong Jiang, Christian D. Gauthier, Sebastian R. Silveira, Caitlin M. Schroeder, Eleonora M. Lad, A D. Proia, Rudolph E. Tanzi, David M. Holtzman, Susanne Krasemann, Dong Feng Chen, Oleg Butovsky

Osteopathic Medicine, Jerry M. Wallace School of

The apolipoprotein E4 (APOE4) allele is associated with an increased risk of Alzheimer disease and a decreased risk of glaucoma, but the underlying mechanisms remain poorly understood. Here, we found that in two mouse glaucoma models, microglia transitioned to a neurodegenerative phenotype characterized by upregulation of Apoe and Lgals3 (Galectin-3), which were also upregulated in human glaucomatous retinas. Mice with targeted deletion of Apoe in microglia or carrying the human APOE4 allele were protected from retinal ganglion cell (RGC) loss, despite elevated intraocular pressure (IOP). Similarly to Apoe retinal microglia, APOE4-expressing microglia did not upregulate neurodegeneration-associated genes, including Lgals3, following …

Spartan Daily, September 13, 2022, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2022

Volume 159, Issue 9

Icc Approved Courses 9-13-22, Angela Brock

Individual Course Committee (ICC)

No abstract provided.

Icc Agenda 9-13-22, Angela Brock

Individual Course Committee (ICC)

No abstract provided.