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#Golead Newsletter, Georgia Southern University

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The George-Anne Reflector Magazine Newsletter, Georgia Southern University

George-Anne Media Group: Newsletters & Magazines

No abstract provided.

Laser Stimulation Of The Skin For Quantitative Study Of Decision-Making And Motivation, Julia Pai, Takaya Ogasawara, Ethan S Bromberg-Martin, Kei Ogasawara, Robert W Gereau, Ilya E Monosov

2020-Current year OA Pubs

Neuroeconomics studies how decision-making is guided by the value of rewards and punishments. But to date, little is known about how noxious experiences impact decisions. A challenge is the lack of an aversive stimulus that is dynamically adjustable in intensity and location, readily usable over many trials in a single experimental session, and compatible with multiple ways to measure neuronal activity. We show that skin laser stimulation used in human studies of aversion can be used for this purpose in several key animal models. We then use laser stimulation to study how neurons in the orbitofrontal cortex (OFC), an area …

Nethnography, Complementing Netnography: A Defensible Praxis For The Online Researcher, Martin Maccarthy

Research outputs 2022 to 2026

This article issues a challenge for interpretive tourism researchers to consider the trove of online data currently disavowed by aficionados of Netnography. Non-dyadic social media data is used by researchers but has been devalued as lacking legitimacy. However, by combining ‘lifeless’ non-dyadic social media with lesser-engaged ethnographic methods a lived proxy can be achieved. Nethnography is a two-part qualitative praxis of spending enough time with the phenomenon to discern meanings with confidence, which is then used to interpret non-dyadic textual discourse. Lesser-engaged ethnographic methods include participants as observers, observers as participants and complete observers. A fourth legitimizer of online interpretation …

Birth Control And The Sixties: The Dialogue Surrounding The First Oral Contraceptive, Eden E. Baize

The Cardinal Edge

No abstract provided.

Targeting Of The Hedgehog Signaling Pathway In Cancer Treatment, Andrew J. Hawes

The Cardinal Edge

The Hedgehog (Hh) signaling pathway is a developmental pathway that is highly conserved evolutionarily. While typically only displaying high activity during embryogenesis, overactivation of the Hh pathway in adults has been linked to multiple forms of cancer including acute myeloid leukemia, myelofibrosis, basal-cell carcinoma, pancreatic ductal adrenal carcinoma, and triple negative breast cancer. The prevalence of Hh activation in many different cancers has made it a prime target for inhibition of these cancers through novel therapies. This literature review sought to assess the current state of cancer treatment through inhibition of Hh signaling. Most current clinical trials involving the pathway …

Evaluation Of Respiratory Function Using Blood Gas Parameters In Yucatan Minipigs Following Spinal Cord Injury, Jackson Gallagher, Monique Morgan, Chase Knibbe, Destiny Gibson, Maxwell Boakye

The Cardinal Edge

There are approximately 17,810 new spinal cord injuries (SCI) in the U.S. each year [1]. Physical damage to the spinal cord has the potential to interfere with normal motor, sensory, and/or autonomic function, such as impairment of the respiratory system. In fact, respiratory insufficiency is the number one cause of mortality and morbidity after SCI. The more rostral the injury, the more likely there will be disruption to normal ventilation (generally rostral to T6) [2]. To conduct relevant preclinical research, it has been shown that large animal models, such as the Yucatan minipig, have a better success rate of translating …

An Interdisciplinary Discussion On Climate Change, Aamira Shah, Jaley F. Adkins, Kelsey Littrell, Priyadarshini Chandrashekhar

The Cardinal Edge

No abstract provided.

A Bucket Case, Beth Broderick

Erma Bombeck Writers' Workshop Blog

I love flying into Oakland, California. On approach, the plane glides over San Francisco Bay, slowly getting lower and lower until it seems it will surely dip a wheel into the water, and as it lands, it appears to touch the earth. It is enchanting. I never tire of watching the drama unfold from my tiny window, though I admit a small knot of worry forms every time.

The Social Value Of Intellectual Property, Alina Ng

Journal Articles

The focus of this paper is not on how intellectual property owners can misuse intellectual property rights in harmful ways in society. Much has already been written about that topic. Instead, this paper is about how to encourage intellectual property owners, especially corporate owners, to make decisions and implement strategies about their intellectual property rights that are socially valuable and positively impactful. This paper argues that if corporate and business owners of intellectual property understand the role that their intellectual property rights can have in creating a positive social impact, the influence that they can have in the market as …

The Guardian The Week Of September 18, 2022, Wright State Student Body

The Guardian Student Newspaper

News articles from The Guardian for the week of September 18, 2022. The Guardian is the official student-run newspaper for Wright State University. It has been published regularly since March of 1965.

Writing A “Good” Autoethnography In Educational Research: A Modest Proposal, Ufuk Keleş

The Qualitative Report

In this paper, I first discuss what autoethnography is elaborating on an autoethnographic spectrum. Then, I draw on several scholars’ understanding of what a “good” autoethnography is and propose a list of suggestions to contribute to autoethnography’s conceptualization and operationalization in qualitative educational research in the future. Believing that a good autoethnography is the work of a scholar who aims for the witty hand of an artist and the sharp/critical mind of a social scientist, I suggest that a good autoethnography (a) creates a sense of transformation through a story of illumination, healing, understanding, and/or learning, (b) engages readers as …

Pathogenesis Of Tobacco-Associated Lung Adenocarcinoma Is Closely Coupled With Changes In The Gut And Lung Microbiomes, Casey T Finnicum, Zahraa Rahal, Maya Hassane, Warapen Treekitkarnmongkol, Ansam Sinjab, Rhiannon Morris, Yuejiang Liu, Elizabeth L Tang, Sarah Viet, Jason L Petersen, Philip L Lorenzi, Lin Tan, Joseph Petrosino, Kristi L Hoffman, Junya Fujimoto, Seyed Javad Moghaddam, Humam Kadara

Faculty, Staff and Students Publications

Microbial dysbiosis has emerged as a modulator of oncogenesis and response to therapy, particularly in lung cancer. Here, we investigate the evolution of the gut and lung microbiomes following exposure to a tobacco carcinogen. We performed 16S rRNA-Seq of fecal and lung samples collected prior to and at several timepoints following (nicotine-specific nitrosamine ketone/NNK) exposure in Gprc5a^−/− mice that were previously shown to exhibit accelerated lung adenocarcinoma (LUAD) development following NNK exposure. We found significant progressive changes in human-relevant gut and lung microbiome members (e.g., Odoribacter, Alistipes, Akkermansia, and Ruminococus) that are closely associated with …

Effect Of Selected Essential Oils Against Zoonoses And Their Epidemiological Survey Among Domestic Rodents In Egypt, Walaa S. Nasser, Micheal William Mikhail, Marwa Yousry Issa, Essam Abdel-Sattar

Bulletin of Faculty of Pharmacy Cairo University

A cross-sectional seroprevalence survey of certain pathogenic zoonses in domestic rodents from Abou El Noumorus district, Egypt, was conducted. In addition, antimicrobial of selected essential oils (EOs) was performed and the Minimum Inhibitory Concentration (MIC) was measured. The overall prevalence of antibodies against tested organisms was determined. MIC of the tested EOs showed a promising result. This study provides a serological evidence about the occurrence of these bacteria among domestic rodents. This information is helpful for determining strategies for rat zoonotic diseases prevention and control. Also, it highlighted the effect of certain EOs against the isolated zoonotic pathogens.

Information Theory And Patent Documents, W. Michael Schuster

Akron Law Review

Recent scholarship has expanded the scope of analytical tools available to patent law researchers. The foundation of information theory published by Claude Shannon has been applied to textual analysis to determine the similarities of patents and to assess a patent’s value. This article presents a theoretical application of information theory to quantify lexical ambiguity and originality in innovation within patent law.

Systemic Inflammatory Response Syndrome And Mechanical Circulatory Support Devices, Mircea R. Mihu, Aly El-Banayosy

Journal of Shock and Hemodynamics

Systemic inflammatory response syndrome is an increased inflammatory state affecting the whole body. Mechanical circulatory support (MCS) is a temporary or permanent form of extracorporeal support that may have an associated complication of an exacerbated inflammatory response to the extracorporeal circuit. This brief review will focus on understanding the complex pathophysiology of inflammatory response to MCS, factors that influence the extent of the inflammatory response, the inflammatory response and outcomes as well as potential therapeutic strategies.

Pollutants Corrupt Resilience Pathways Of Aging In The Nematode C. Elegans, Andrea Scharf, Annette Limke, Karl Heinz Guehrs, Anna Von Mikecz

Biological Sciences Faculty Research & Creative Works

Delaying aging while prolonging health and lifespan is a major goal in aging research. One promising strategy is to focus on reducing negative interventions such as pollution and their accelerating effect on age-related degeneration and disease. Here, we used the short-lived model organism C. elegans to analyze whether two candidate pollutants corrupt general aging pathways. We show that the emergent pollutant silica nanoparticles (NPs) and the classic xenobiotic inorganic mercury reduce lifespan and cause a premature protein aggregation phenotype. Comparative mass spectrometry revealed that increased insolubility of proteins with important functions in proteostasis is a shared phenotype of intrinsic- and …

Medical School Watercooler Newsletter - September 16, 2022, Lindsey Lyle

Watercooler Newsletter

This is the September 16, 2022 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents include:

• New neonatology division chief joins Children’s &Women’s Hospital
• USA Center for Lung Biology announces Murray Bander Faculty Development Award recipients
• Med students invited to attend GME virtual open house
• Borchert receives $1 million from National Science Foundation to study Salmonella survival
• Menger wins Young Neurosurgeon Award from Congress of Neurological Surgeons

Business Policy As Responsible Leadership: A Collection Of Open Educational Resources For Integrating Sustainability Into The Strategy Curriculum., Richard Jonsen

Open Educational Resources

This collection of instructional materials is designed for undergraduate management instructors desiring to integrate sustainability into the Business Strategy Curriculum.

There are five sections:

• Introduction and Overview
• Economics of Mutuality
• Summative Cases Focused on Sustainability
• Classroom Discussion Cases with Sustainability Themes
• Preparing Students for Discussion of Controversial Topics

Teaching Qubits To Sing: Mission Impossible?, E Miranda, Bn Siegelwax

School of Art, Design and Architecture

This paper introduces QuSing, a system that learns to sing new tunes by listening to examples. QuSing extracts sequencing rules from input music and uses these rules to generate new tunes, which are sung by a vocal synthesiser. We developed a method to represent rules for musical composition as quantum circuits. We claim that such musical rules are quantum native: they are naturally encodable in the amplitudes of quantum states. To evaluate a rule to generate a subsequent event, the system builds the respective quantum circuit dynamically and measures it. After a brief discussion about the vocal synthesis methods that …

Breakdown Of The Central Synapses In C9orf72-Linked Als/Ftd, Layla T. Ghaffari, Davide Trotti, Aaron R. Haeusler, Brigid K Jensen

Department of Neuroscience Faculty Papers

Amyotrophic lateral sclerosis (ALS) is a progressive, fatal neurodegenerative disease that leads to the death of motor and cortical neurons. The clinical manifestations of ALS are heterogenous, and efficacious treatments to significantly slow the progression of the disease are lacking. Cortical hyper-excitability is observed pre-symptomatically across disease-causative genetic variants, as well as in the early stages of sporadic ALS, and typically precedes motor neuron involvement and overt neurodegeneration. The causes of cortical hyper-excitability are not yet fully understood but is mainly agreed to be an early event. The identification of the nucleotide repeat expansion (GGGGCC)n in the C9ORF72 gene has …

Japanese Buddhist Women In Hawai‘I: Waves Of Change, Karma Lekshe Tsomo

Theology and Religious Studies: Faculty Scholarship

Beginning in the latter half of the nineteenth century, successive waves of Japanese Buddhist immigrants settled in the Kingdom of Hawai‘i, bringing with them a variety of Japanese Buddhist schools and traditions. Overcoming many hardships, Japanese immigrant women worked with great devotion to help establish numerous temples in the Hawai‘i through Buddhist women’s associations known as Fujinkai. These dedicated women not only maintained ancestral Buddhist practices but also integrated Japanese Buddhist, native Hawaiian, and other cultural elements in ways that were entirely new. Persevering through the war years and through successive waves of cultural adaptation, they transmitted and protected Buddhist …

Enrofloxacin And Sulfamethoxazole Sorption On Carbonized Leonardite: Kinetics, Isotherms, Influential Effects, And Antibacterial Activity Toward S. Aureus Atcc 25923, Chanat Chokejaroenrat, Chainarong Sakulthaew, Khomson Satchasataporn, Daniel D. Snow, Tarik E. Ali, Mohammed A. Assiri, Apichon Watcharenwong, Saksit Imman, Nopparat Suriyachai, Torpong Kreetachat

Nebraska Water Center: Faculty Publications

Excessive antibiotic use in veterinary applications has resulted in water contamination and potentially poses a serious threat to aquatic environments and human health. The objective of the current study was to quantify carbonized leonardite (cLND) adsorption capabilities to remove sulfamethoxazole (SMX)- and enrofloxacin (ENR)-contaminated water and to determine the microbial activity of ENR residuals on cLND following adsorption. The cLND samples prepared at 450^oC and 850^oC (cLND450 and cLND550, respectively) were evaluated for structural and physical characteristics and adsorption capabilities based on adsorption kinetics and isotherm studies. The low pyrolysis temperature of cLND resulted in a …

2022-2023 Granted Cases, Institute Of Bill Of Rights Law, William & Mary Law School

Supreme Court Preview

No abstract provided.

Robert Kingston Vickery, Jr.—In Memoriam, E. Durant Mcarthur

Western North American Naturalist

No abstract provided.

Boys Don’T Cry: Trauma, Trauma Narrative And Masculine Practice Among Young Male Who Engaged In Harmful Sexual Behaviour, B Zaniewski, R Dallos, J Stedmon, P Welbourne

School of Health Professions

Compelling evidence suggests that majority of young men who engaged in harmful sexual behaviour (HSB) were subjected to various forms of trauma and adverse childhood experiences. This research explores lived experience of a group of young men who engaged in HSB, what sense they made of it and how their positioned themselves towards these events including HSB, so they are able to maintain their self-integrity. It also explores impact of lived experience with consideration for broader family and cultural discourses. Transition to Adulthood Attachment Interview and Semi-structured interview were employed and Dynamic- Maturation Model of attachment were utilised for this …

How Digital Is Agriculture In A Subset Of Countries From South America? Adoption And Limitations, Laila A. Puntel, É. L. Bolfe, R. J. M. Melchiori, R. Ortega, G. Tiscornia, A. Roel, F. Scaramuzza, S. Best, A. G. Berger, D. S. S. Hansel, D. Palacios Durán, G. R. Balboa

Department of Agronomy and Horticulture: Faculty Publications

Digital agriculture (DA) can contribute solutions to meet an increase in healthy, nutritious, and affordable food demands in an efficient and sustainable way. South America (SA) is one of the main grain and protein producers in the world but the status of DA in the region is unknown. A systematic review and case studies from Brazil, Argentina, Uruguay, and Chile were conducted to address the following objectives: (1) quantify adoption of existing DA technologies, (2) identify limitations for DA adoption; and (3) summarise existing metrics to benchmark DA benefits. Level of DA adoption was led by Brazil and Argentina followed …

Antidepressant Effect Of Ketamine On Inflammation-Mediated Cytokine Dysregulation In Adults With Treatment-Resistant Depression: Rapid Systematic Review, Shiryn D. Sukhram, Grozdena Yilmaz, Jianying Gu

Publications and Research

Background. Major depressive disorder (MDD) and treatment-resistant depression (TRD) represent a global source of societal and health burden. To advise proper management of inflammation-related depression among TRD patients, it is important to identify therapeutic clinical treatments. A key factor is related to proinflammatory cytokines such as interleukin- (IL-) 1β, IL-6, and tumor necrosis factor- (TNF-) α which have been implicated in the pathogenesis of depressive symptoms in MDD patients. Ketamine may provide an anti-inflammatory therapeutic strategy by targeting proinflammatory pathways associated with depressive disorders, which may be exacerbated in the ageing population with TRD.

Objective. Despite a burgeoning body of …

Epigenetic Dysregulations In Arsenic-Induced Carcinogenesis, Ranakul Islam, Lei Zhao, Yifang Wang, Grace Lu-Yao, Ling-Zhi Liu

Department of Medical Oncology Faculty Papers

Arsenic is a crucial environmental metalloid whose high toxicity levels negatively impact human health. It poses significant health concerns to millions of people in developed and developing countries such as the USA, Canada, Bangladesh, India, China, and Mexico by enhancing sensitivity to various types of diseases, including cancers. However, how arsenic causes changes in gene expression that results in heinous conditions remains elusive. One of the proposed essential mechanisms that still has seen limited research with regard to causing disease upon arsenic exposure is the dysregulation of epigenetic components. In this review, we have extensively summarized current discoveries in arsenic-induced …

Targeting Ras Mutant Colorectal Cancer With Dual Inhibition Of Mek And Cdk4/6, Alexey V Sorokin, Preeti Kanikarla Marie, Lea Bitner, Muddassir Syed, Melanie Woods, Ganiraju Manyam, Lawrence N Kwong, Benny Johnson, Van K Morris, Philip Jones, David G Menter, Michael S Lee, Scott Kopetz

Faculty, Staff and Student Publications

UNLABELLED: KRAS and NRAS mutations occur in 45% of colorectal cancers, with combined MAPK pathway and CDK4/6 inhibition identified as a potential therapeutic strategy. In the current study, this combinatorial treatment approach was evaluated in a co-clinical trial in patient-derived xenografts (PDX), and safety was established in a clinical trial of binimetinib and palbociclib in patients with metastatic colorectal cancer with RAS mutations. Across 18 PDX models undergoing dual inhibition of MEK and CDK4/6, 60% of tumors regressed, meeting the co-clinical trial primary endpoint. Prolonged duration of response occurred predominantly in TP53 wild-type models. Clinical evaluation of binimetinib and palbociclib …