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Somatostatin Regulates Circadian Clock Function And Photic Processing, Deborah A. M. Joye

Dissertations (1934 -)

Daily and seasonal rhythms are programmed by neural circuits that use daily timing and duration of light to anticipate predictable environmental changes (i.e., day length, temperature, food, predation). Daily and annual changes in light modulate human health to produce both positive and negative effects, but neural mechanisms underlying light-driven changes in the brain remain poorly understood. In mammals, light is processed and encoded by the brain’s central clock, the suprachiasmatic nucleus (SCN). The SCN also encodes day length (i.e., photoperiod) to regulate annual fluctuations in mammalian physiology, but it’s not clear precisely how the SCN network achieves this. One signal …

Kinetics Of Isotope-Labeled Pathways In The Ozone Forming Recombination Reaction, Elizaveta Grushnikova

Dissertations (1934 -)

The ozone layer in Earth’s atmosphere is unique and plays a vital role in the development of life. Studying the mechanism behind ozone formation helps us understand the development of our planet’s atmosphere. We focus here on the anomalous mass-independent isotope effect.1 In 1981, Mauersberger et al.2 performed an experiment using weather balloons, resulting in the discovery of the anomalous isotope effect for ozone formation. Since then, other chemists have continued to investigate the theory behind this phenomenon. To understand the nature of the isotope effect, we must consider all stages of ozone formation. The basic reaction for ozone formation …

The Ventral Hippocampus Dynamically Regulates Amygdala Encoding And Learned Fear, Matthew Richard Herbst

Dissertations (1934 -)

The nervous system has evolved a set of survival circuits optimized to respond to environmental threats. Adaptive threat responding requires learning to predict when and where a threat may occur based on available cues. Such learning depends on a distributed network of brain structures, but there is much we do not understand about how these brain areas interact to support fear memory. Addressing this gap is crucial for understanding anxiety- and fear-related disorders as dysfunction in fear learning networks is implicated in the development and persistence of pathological fear states. In my dissertation work, I used a rodent model of …

Investigations Into The Negative Impact Of Temperature Stress On Fertility In Wild Strains Of Caenorhabditis Elegans, Nicholas B. Sepulveda

Dissertations (1934 -)

Sexual reproduction and its coincident genetic recombination are powerful adaptive strategies. However, sexual reproduction has disadvantages. One ancient and conserved disadvantage is temperature sensitivity. In organisms diverse as plants, insects, nematode worms, and humans, as temperatures increase, fertility decreases. The goal of this dissertation is to examine the negative impact of elevated temperature stress on fertility in sexually reproducing organisms using wild strains of Caenorhabditis elegans. C. elegans presents a unique opportunity to study these effects broadly in two contexts, as worms may be either self-fertile hermaphrodites that produce both egg and sperm or males which produce only sperm. In …

Translation Al Mercato Del Pesce: The Importance Of Human Input For Machine Translation, Emma Y. Schechter , '23

Senior Theses, Projects, and Awards

This thesis investigates translation of Italian idioms and metaphors into English, and the difficulties encountered by Machine Translation in this process. I use a framework of foreign concepts to explain many of the difficulties, as well as interviews with native Italian and English speakers to provide further context for the cultural knowledge encoded in figurative language. I conclude that in Machine Translation a consistent human input interface as well as a continuous training in language corpora is crucial to improve the accuracy of translated metaphors and idioms, using Italian to English translation as a case study.

Far-Fetched Uses Of Drug Detection Dog Alerts: A Case Note On United States V. Braddy, Daniel Kaseff

Cardozo Law Review

No abstract provided.

Relationship Of Spirituality, Self-Awareness, And Effective Leadership Among Lay Catholic High School Leaders In Nigeria, Emmanuel I. Ugwejeh

Dissertations (1934 -)

First, this research measured the spirituality, self-awareness, and leadership effectiveness of 70 lay Catholic high school leaders in Nigeria to gain insights into these leaders' self-awareness, spirituality, and effectiveness. Second, using multiple regression analysis, it also tried to determine if an association exists between lay-Catholic high school leaders’ self-rated spirituality, self-rated self-awareness, supervisor-rated self-awareness, and supervisor-rated effectiveness of the same Catholic high school leaders. Third, it also tried to determine if self-rated self-awareness, self-rated spirituality, and supervisors’ rated self-awareness would together predict leadership effectiveness among the same lay Catholic high school leaders. The study suggests mixed results. Whereas the supervisor-rated …

Monsters

In Case You Missed It

OCTOBER 2022

Guilt And Compensation: The Interplay Between Maternal Emotions And Parent–Child Relationships In Migrant Families, Meng Li

Communication Studies Faculty Works

Objective: The study aimed to explore how mother–child interactions shape Chinese rural–urban migrant women's maternal guilt, and vice versa. Background: Migrant mothers are documented to experience intense feelings of guilt due to long-term separation from their children. Research on maternal guilt frequently conceptualizes guilt as a negative self-judgement of mothers without considering the bidirectional interplay between mother–child interactions and mothers' guilt feelings. Method: Data were drawn from semistructured interviews with 24 Chinese rural–urban migrant mothers who voiced profound guilt for leaving their children behind. The research was carried out following a grounded theory approach. Results: Results demonstrate left-behind children's power …

Historical Examples And Evaluations Of Visions And Dreams, Wilfred T. Adderley Sr.

Journal of Adventist Mission Studies

This article asks whether there has been an ecclesiastical shift away from spiritual gifts—especially believing and accepting that God still sends visions and dreams during this present period in history? Is the Holy Spirit continuing to speak to humans through visions and dreams? These questions will be answered, and the seven-element biblical model will be used to evaluate visions and dreams. I will review documents from the Ante Nicene Fathers, will look at the works of Martin Luther and John Wesley, and Adventist pioneers William Miller and Ellen White concerning dreams and visions. Documented dream experiences from Muslim cultures and …

Symbols From Revelation In Dreams And Visions In The Islamic World, Ibrahim Abed Al-Masih

Journal of Adventist Mission Studies

No abstract provided.

Evaluating The Impact Of Submarine Groundwater Discharge On Nutrients And Trace Elements In Coastal Systems: The Examples Of The Tuckean Swamp (Australia) And The Mississippi Sound (Usa), Amy Moody

Dissertations

Submarine groundwater discharge (SGD) is the advective flow of both fresh terrestrial groundwater and recirculating seawater through aquifer sediments, which is released into the coastal ocean. In this dissertation, I evaluated the impact of SGD on the distributions and input of trace metals and nutrients. In the Tuckean Swamp, an estuary in Australia dominated by coastal acid sulfate soils, I determined the impact of groundwater on Ba and U during the flood season, when the local aquifer is flushed out after a rapid increase in water table elevation. For Ba and U, groundwater contributed up to 18 and 66 % …

Creating Connections To Landscapes And Cultures Through The Plants Of Montana And The Interior Northwest, Susan Elise Teitelman

Graduate Student Portfolios, Professional Papers, and Capstone Projects

This portfolio ties together concepts from the disciplines of ethnobotany, botany, and Traditional Ecological Knowledge (TEK). It draws on themes of native plant preservation and restoration as well as ethics of plant collection and public education regarding the native flora of Montana and the broader Interior Northwest. It is my intention to explore the many ways humans connect with plants and how they may inform our sense of place, and to provide education about the benefits of native plants so people may feel more inclined to protect them and live in right relationship with the natural environment. Overall, this portfolio …

Aesthetics, Cognition, Emotion, And Multi-Modal Communication., Dyutiman Mukhopadhyay Dr

Interdisciplinary Collection

Profile and Abstract of the work : Professor in Information Arts & Information Design (SMI, MAHE); Cognitive scientist and fine artist working on experimental aesthetics, art psychology, and art philosophy

Dr Dyutiman Mukhopadhyay is a Professor in Information Arts & Information Design Practices and at the Centre for Reimagining Transitions, Srishti Manipal Institute of Art, Design & Technology, Manipal Academy of Higher Education, India. He is a cognitive scientist, biologist, artist, and writer whose work explores how humans respond to constructs of representation and reality at the intersection of the arts and sciences. His focus areas include aesthetics, socio-cultural psychology, …

Using Pomegranate Peel Extract To Change The Adverse Effect Of Ethephon By Enhancing Its Antioxidant, Anti-Inflammatory, And Anti-Apoptotic Effects In Rats, Hamid Mahmood Abdullah Daabo

Baghdad Science Journal

Organophosphorus insecticide and growth regulator namely Ethephon (2-chloroethylphosphonic acid) are widely used as a ripening process accelerator and a cultivation duration inhibitor. Pomegranate extract (PPE) has recently been taken into consideration due to its pharmacological effects especially those associated with renal diseases. Thus, this study aims to investigate the possible protective effect of PPE against ethephon-induced nephrotoxicity in rats. In this study four groups of adult male rats were divided into control group, PPE 400 mg/kg group, Ethephon 250 mg/kg group, and finally, PPE + Ethephon group (treated with the same dose of PPE group and Ethephon group). In the …

Identifying Phenotypic Expansions For Congenital Diaphragmatic Hernia Plus (Cdh+) Using Decipher Data, Amy Hardcastle, Aliska M Berry, Ian M Campbell, Xiaonan Zhao, Pengfei Liu, Amanda E Gerard, Jill A Rosenfeld, Saumya D Sisoudiya, Andres Hernandez-Garcia, Sara Loddo, Silvia Di Tommaso, Antonio Novelli, Maria L Dentici, Rossella Capolino, Maria C Digilio, Ludovico Graziani, Cecilie F Rustad, Katherine Neas, Giovanni B Ferrero, Alfredo Brusco, Eleonora Di Gregorio, Diana Wellesley, Claire Beneteau, Madeleine Joubert, Kris Van Den Bogaert, Anneleen Boogaerts, Dominic J Mcmullan, John Dean, Maria G Giuffrida, Laura Bernardini, Vinod Varghese, Nora L Shannon, Rachel E Harrison, Wayne W K Lam, Shane Mckee, Peter D Turnpenny, Trevor Cole, Jenny Morton, Jacqueline Eason, Marilyn C Jones, Rebecca Hall, Michael Wright, Karen Horridge, Chad A Shaw, Wendy K Chung, Daryl A Scott

Duncan NRI Faculty and Staff Publications

Congenital diaphragmatic hernia (CDH) can occur in isolation or in conjunction with other birth defects (CDH+). A molecular etiology can only be identified in a subset of CDH cases. This is due, in part, to an incomplete understanding of the genes that contribute to diaphragm development. Here, we used clinical and molecular data from 36 individuals with CDH+ who are cataloged in the DECIPHER database to identify genes that may play a role in diaphragm development and to discover new phenotypic expansions. Among this group, we identified individuals who carried putatively deleterious sequence or copy number variants affecting CREBBP, SMARCA4, …

Development Of An In Vitro Model To Assess Endothelial Dysfunction From Coarctation Of The Aorta, Dylan James Schock

Master's Theses (2009 -)

Coarctation of the aorta (CoA) is a common congenital heart defect characterized by a stenosis of the descending thoracic aorta. Surgical treatment can alleviate the stenosis and restore physiologic blood flow; however, patients frequently develop cardiovascular morbidity with hypertension (HTN) being most common. Identifying the mechanisms involved with the onset of HTN in CoA patients is difficult due to confounding factors including the severity of coarctation, age of correction, and general lifestyle factors. To account for the variability seen in humans, a rabbit model of CoA and correction was developed previously. Microarray analysis of aortic samples from the model showed …

Comparison Of 3d Bio-Printed Ipsc-Cms Derived From Healthy Donors And Patients With Hlhs, Wei He

Master's Theses (2009 -)

Hypoplastic left heart syndrome (HLHS) is an extremely severe form of congenital heart disease, but current treatments are not adequate. In order to find more effective treatments, we need to reproduce in vitro the physiological characteristics of cardiomyocytes associated with HLHS. Such a tissue model could be of great help to current medical research, and 3D printing technology is an effective tool for this purpose. We print layer-by-layer cardiomyocytes from both healthy and HLHS patients with laminin-based bioink to form a three-dimensional model. With our 3D cell culture technology, this model can simulate the growth conditions of cardiomyocytes in vivo. …

Dietary Inorganic Nitrate As An Ergogenic Aid: An Expert Consensus Derived Via The Modified Delphi Technique, Oliver M. Shannon, Jason D. Allen, Raul Bescos, Louise Burke, Tom Clifford, Chris Easton, Javier T. Gonzalez, Andrew M. Jones, Kristin L. Jonvik, Filip J. Larsen, Peter Peeling, Barbora Piknova, Mario Siervo, Anni Vanhatalo, Kerry Mcgawley, Simone Porcelli

School of Health Professions

Abstract Introduction Dietary inorganic nitrate is a popular nutritional supplement, which increases nitric oxide bioavailability and may improve exercise performance. Despite over a decade of research into the effects of dietary nitrate supplementation during exercise there is currently no expert consensus on how, when and for whom this compound could be recommended as an ergogenic aid. Moreover, there is no consensus on the safe administration of dietary nitrate as an ergogenic aid. This study aimed to address these research gaps. Methods The modified Delphi technique was used to establish the views of 12 expert panel members on the use of …

The Gut Microbial Metabolic Capacity Of Microbiome-Humanized Vs. Wild Type Rodents Reveals A Likely Dual Role Of Intestinal Bacteria In Hepato-Intestinal Schistosomiasis, Alba Cortés, John Martin, Bruce A. Rosa, Klara A. Stark, Simon Clare, Catherine Mccarthy, Katherine Harcourt, Cordelia Brandt, Charlotte Tolley, Trevor D. Lawley, Makedonka Mitreva, Matthew Berriman, Gabriel Rinaldi, Cinzia Cantacessi

2020-Current year OA Pubs

Increasing evidence shows that the host gut microbiota might be involved in the immunological cascade that culminates with the formation of tissue granulomas underlying the pathophysiology of hepato-intestinal schistosomiasis. In this study, we investigated the impact of Schistosoma mansoni infection on the gut microbial composition and functional potential of both wild type and microbiome-humanized mice. In spite of substantial differences in microbiome composition at baseline, selected pathways were consistently affected by parasite infection. The gut microbiomes of infected mice of both lines displayed, amongst other features, enhanced capacity for tryptophan and butyrate production, which might be linked to the activation …

Young Transposable Elements Rewired Gene Regulatory Networks In Human And Chimpanzee Hippocampal Intermediate Progenitors, Sruti Patoori, Samantha M Barnada, Christopher Large, John I Murray, Marco Trizzino

Department of Biochemistry and Molecular Biology Faculty Papers

The hippocampus is associated with essential brain functions, such as learning and memory. Human hippocampal volume is significantly greater than expected compared with that of non-human apes, suggesting a recent expansion. Intermediate progenitors, which are able to undergo multiple rounds of proliferative division before a final neurogenic division, may have played a role in evolutionary hippocampal expansion. To investigate the evolution of gene regulatory networks underpinning hippocampal neurogenesis in apes, we leveraged the differentiation of human and chimpanzee induced pluripotent stem cells into TBR2 (or EOMES)-positive hippocampal intermediate progenitor cells (hpIPCs). We found that the gene networks active in hpIPCs …

Assessing The State Of Rainwater For Consumption In A Community In Dire Need Of Clean Water: Human And Health Risk Using Herisk, Imokhai Theophilus Tenebe, Praisegod C. Emenike, E. O. Babatunde, J. B. Neris, Omowunmi H. Fred-Ahmadu, Nathaniel Dede-Bamfo, Egbe Etu Etu, Nkpa M. Ogarekpe, Joshua Emakhu, Nsikak U. Benson

Faculty Research, Scholarly, and Creative Activity

This study examines the case of Ekpoma community, Edo State, Nigeria, where roof-harvested rainwater is the primary source of water for drinking and domestic purposes. Eight potentially toxic elements (PTEs), namely aluminum, chromium, copper, iron, manganese, nickel, lead, and zinc, were detected in rainwater samples, collected and analyzed from 54 sampling locations across the community. The elemental concentrations were quantified using atomic absorption spectrophotometry and compared using the regulatory standards of the World Health Organization, United States Environmental Protection Agency, and Nigerian Drinking Water Quality Standards. The PTEs detected in the rainwater samples can be attributed to the nature of …

Interviewed For Law And Other Things Podcast, Gauri Pillai, S Atrey

Popular Media

In this episode, our legal editor Eeshan Sonak is in conversation with Shreya Atrey and Gauri Pillai discussing their rewriting of Nergesh Meerza, which dealt with the constitutionality of Air India Employee Service Regulations. So without further delay, let’s dive right in.

René Van Woudenberg, The Epistemology Of Reading And Interpretation, Dolores G. Morris

Faith and Philosophy: Journal of the Society of Christian Philosophers

No abstract provided.

Chairs Of Excellence Annual Report 2022, Tennessee. Higher Education Commission.

Academic Programs and Workforce Reports

No abstract provided.

Cattle Industry Funding Scheme Annual Report 2021/2022, Department Of Primary Industries And Regional Development, Western Australia, Cattle Industry Funding Scheme

Agriculture reports

No abstract provided.

A Multiple-Case Study: Motivating Students With Disabilities In Personalized Literacy Instruction, Courtney Kozelski

Theses and Dissertations

Adolescents often experience a decline in motivation, yet support for basic psychological needs can prevent such a decline. Individuals with disabilities face particularly high motivational obstacles, placing them at the center of this action research study. This study took place within a special education classroom during one school year. The intervention unfolded over the course of the year, using personalized learning to support students’ basic psychological needs and provide sources of self-efficacy. The findings lend support to previous studies, indicating literacy motivation can be promoted through implementation of a needs-supportive personalized learning intervention that builds upon both self-efficacy and self-determination …

Investigating The Impact Of Endothelial Dysfunction And Aging On Vascular Remodeling Using Mouse Models, Liya Du

Theses and Dissertations

Endothelial dysfunction, characterized by a reduction in the bioavailability of nitric oxide (NO), is a major factor in the initiation and progression of atherosclerosis, an age-related chronic inflammatory process in the arterial wall and the leading cause of mortality and morbidity globally. A better understanding of alterations in vascular structure and function associated with endothelial dysfunction can facilitate the early detection of atherosclerosis and the development of potential pharmaceutical interventions. This study aims to clarify the impact of endothelial dysfunction in conjunction with aging on the microstructure of aortic extracellular matrix (ECM) and to elucidate the relationship between microstructural adaptation …

Spatial And Age Disparities In Covid-19 Outcomes, Qian Huang

Theses and Dissertations

COVID-19 has caused significant social, economic, environmental, and political impacts globally and affected communities unequally in the U.S. The pandemic has also sparked interest in age-specific manifestations of infection, for example, studies confirmed the risk of increasing age with COVID-19 severity. However, the nonstationarity effects of health determinants among age groups have not been well examined. This study aims to explore the nonstationarity effects of social, behavioral, environmental, health care access, and political contexts on COVID-19 outcomes. This study poses three broad questions: 1) how did COVID-19 vaccinations align with COVID-19 daily cases and deaths in the United States; 2) …

In This Issuereview Articleoriginal Articlescase Report

Saudi Medical Journal

No abstract provided.