Digital Commons Network^™

Research Progress On Application Of Eggshell Membrane, Zhang Gai-Ping, Niu Ming-Fu, He Jiao

Food and Machinery

This review summarized the source, structural properties and applications of eggshell membrane(ESM)in various industries. The application limitation and future prospect of ESM were analyzed and prospected.

Research Progress On The Application Of Composite Hydrogel In Food, Wang Shao-Qing, Mu Ming-Wei, Zhang Bo, Deng Na, Wang Jian-Hui

Food and Machinery

At present, most hydrogels used in the food industry are natural polymers, with poor mechanical properties and high moisture content, which is easy to be contaminated by microorganisms, making it difficult to meet the use needs. In recent years, new composite hydrogels loaded with active substances prepared from natural and synthetic polymers or modified natural polymers have been increasingly used in the food field..Starting from the preparation method of composite hydrogels, this paper introduces its application status in food packaging materials, fat and starch substitution, bioactive molecule delivery, rapid detection of microorganisms, and prospects the development trend of composite hydrogels …

Research Progress On Active Ingredients And Pharmacological Functions Of Lotus Leaf, Li Yi-Long, Shang Bo-Hao, Wang Jian-Hui, Liu Zhong-Hua, Zhu Ming-Zhi

Food and Machinery

The main active ingredients in lotus leaves were introduced in this review, including flavonoids, alkaloids, volatile oils, terpenoids, polysaccharides, and organic acids. The pharmacological functions of lotus leaves, such as lipid-lowering and anti-obesity activities, anti-oxidant, anti-bacterial, and blood-lowering activities, protective effects of the cardiovascular system, nervous system, and liver, and anti-tumor activity were also summarized. The relative research and application were prospected in order to provide references for the comprehensive utilization of lotus leaf resources.

Evaluating Growth Rates Of The Eastern Oyster (Crassostrea Virginica) And Water Quality For Oyster Restoration Sites At City Island, Bronx, Ny, Cody L. Jernigan

Theses and Dissertations

Oyster growth and water quality were monitored at four sites at City Island, Bronx, NY, to determine suitability for oyster reef restoration. Significant growth occurred at two sites and water quality was not indicated as a contributing factor. Oyster growth at all sites indicate appropriate conditions for oyster reef restoration.

Methods For Drone Trajectory Analysis Of Bottlenose Dolphins (Tursiops Truncatus), Jillian D. Bliss

Theses and Dissertations

With the increase in the use of UAS (Unmanned Aerial Systems) for marine mammal research, there is a need for the development of methods of analysis to transform UAS high resolution video into quantitative data. This study sought to develop a preliminary method of analysis that would quantify and present a way to visualize the dynamics and relative spatial distribution and changes in distribution of bottlenose dolphins (Tursiops truncatus) in the waters of Turneffe Atoll, Belize. This approach employs a previously developed video tracking program ‘Keypoint Tracking’ that enables manual tracking of individual dolphins and the creation of …

Acute Hemiplegia And Ataxia From Lyme Disease, Shaili Babbar, Jonathan Galati, Jasmine Corona, Sohail Zahid

Cooper Rowan Medical Journal

Lyme disease is a zoonotic illness caused by Borrelia burgdorferi, which present with skin, joint, heart, and central nervous system complications. Central nervous system manifestations of this disease are common, and typically include meningitis, facial nerve palsies, and radiculoneuritis. In this case report, we present a patient who presented with acute right sided hemiplegia and ataxia with negative neuroimaging findings of stroke, inflammation, or mass. Further investigation with cerebrospinal fluid studies and infectious panels revealed the patient had active Lyme disease. The patient improved his motor function, coordination and sensation with ceftriaxone treatment over a few weeks. Acute hemiplegia and …

An Rna Interference (Rnai) Toolkit And Its Utility For Functional Genetic Analysis Of Leishmania (Viannia), Lon-Fye Lye, Katherine L Owens, Soojin Jang, Joseph E Marcus, Erin A Brettmann, Stephen M Beverley

2020-Current year OA Pubs

RNA interference (RNAi) is a powerful tool whose efficacy against a broad range of targets enables functional genetic tests individually or systematically. However, the RNAi pathway has been lost in evolution by a variety of eukaryotes including most Leishmania sp. RNAi was retained in species of the

Genetic Population Dynamics Of The Critically Endangered Scalloped Hammerhead Shark (Sphyrna Lewini) In The Eastern Tropical Pacific, Sydney P. Harned, Andrea Bernard, Pelayo Salinas-De-Leon, Marissa Mehlrose, Jenifer Suarez, Yolani Robles, Sandra Bessudo Lion, Felipe Ladino, Andrés López Garo, Ilena Zanella, Kevin A. Feldheim, Mahmood Shivji

Biology Faculty Articles

The scalloped hammerhead shark, Sphyrna lewini, is a Critically Endangered, migratory species known for its tendency to form iconic and visually spectacular large aggregations. Herein, we investigated the population genetic dynamics of the scalloped hammerhead across much of its distribution in the Eastern Tropical Pacific (ETP), ranging from Costa Rica to Ecuador, focusing on young-of-year animals from putative coastal nursery areas and adult females from seasonal aggregations that form in the northern Galápagos Islands. Nuclear microsatellites and partial mitochondrial control region sequences showed little evidence of population structure suggesting that scalloped hammerheads in this ETP region comprise a single …

Design And Implementation Of On-Line Nondestructive Rapid Testing System For Wheat Flour Quality, Sun Xiao-Rong, Zheng Dong-Yu, Liu Cui-Ling, Wu Jing-Zhu, Jin Jia-Rui

Food and Machinery

Objective: This study aimed to detect the quality of wheat flour quickly and non-destructively. Methods: The online detection system for wheat flour quality was built in the experiment, which mainly includes the flowing four parts: micro near-infrared spectrometer integrated device, production line adjustable speed simulation device, spectrum online acquisition and control software and online modeling and analysis software. Different modeling algorithms were used to establish quantitative analysis models for moisture, ash and gluten, and the robustness of the online quantitative analysis model was optimized. The influence of different experimental conditions on the modeling results was analyzed. Results: …

Research Highlights, Noopur Kumari, Babita Rani Kondle

Indian Journal of Research in Homoeopathy

Summary of the studies has been highlighted from Sep till Nov 2022.

Cardiac Neural Crest And Cardiac Regeneration, Shannon Erhardt, Jun Wang

Faculty, Staff and Student Publications

Neural crest cells (NCCs) are a vertebrate-specific, multipotent stem cell population that have the ability to migrate and differentiate into various cell populations throughout the embryo during embryogenesis. The heart is a muscular and complex organ whose primary function is to pump blood and nutrients throughout the body. Mammalian hearts, such as those of humans, lose their regenerative ability shortly after birth. However, a few vertebrate species, such as zebrafish, have the ability to self-repair/regenerate after cardiac damage. Recent research has discovered the potential functional ability and contribution of cardiac NCCs to cardiac regeneration through the use of various vertebrate …

English-Thai Conceptual Metaphor Translation In Skincare Advertisements, Onsurang Saengsomsurasak, Tongtip Poonlarp

Journal of Letters

This article explores English-to-Thai translations of conceptual metaphors in skincare advertisements on websites. Through a quantitative and qualitative analysis of 120 skincare advertisements and their translations from eight brands collected from their official websites between 2019 and 2021, this study reveals the ten most common conceptual metaphors in skincare advertisements: war metaphors, health metaphors, human-being metaphors, plant and cultivation metaphors, light metaphors, textile and clothing metaphors, machine metaphors, food and nutrition metaphors, cleaning action metaphors, and container metaphors. The most frequent translation strategy found is retention of the source-text conceptual metaphor. Interestingly, addition of a new metaphor into the target …

Establishment Of An In Vivo Streptozotocin-Induced Type 1 Diabetes Model Recapitulating Early Brain And Retinal Fibrosis, Kia Bourdot, Lucy Dawson, Igor Kuzin, Arturo Bravo Nuevo, Zeus Antonello

Cooper Rowan Medical Journal

INTRODUCTION: Diabetes has risen to one of the top American public health concerns. The hyperglycemic state of chronic diabetes leads to microvascular and macrovascular changes that predispose patients to delayed wound healing and organ fibrosis. The validation of models to specifically detect early, quantifiable fibrotic changes seen in the diabetic state is of fundamental importance for understanding the diabetic pathophysiology and exploring earlier management options. Here, we investigated if we could detect early signs of internal fibrosis in a streptozotocin (STZ) diabetic mouse model by quantifying α-SMA expression in various organs using flow cytometry.

METHODS: We used a low-dose STZ-induced …

Safety And Microbiological Activity Of Phage Therapy In Persons With Cystic Fibrosis Colonized With Pseudomonas Aeruginosa: Study Protocol For A Phase 1b/2, Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial, Pranita D Tamma, Maria Souli, Michael Billard, Joseph Campbell, Douglas Conrad, Damon W Ellison, Beth Evans, Scott R Evans, Kerryl E Greenwood-Quaintance, Andrey A Filippov, Holly S Geres, Toshimitsu Hamasaki, Lauren Komarow, Mikeljon P Nikolich, Thomas P Lodise, Seema U Nayak, Carmelle Norice-Tra, Robin Patel, David Pride, Janie Russell, Daria Van Tyne, Henry F Chambers, Vance G Fowlerjr, Robert T Schooley, Antibacterial Resistance Leadership Group

Faculty, Staff and Student Publications

BACKGROUND: Bacteriophages (phages) are a promising anti-infective option for human disease. Major gaps remain in understanding their potential utility.

METHODS: This is a randomized, placebo-controlled, double-blind study of a single dose of intravenous phage in approximately 72 clinically stable adult cystic fibrosis volunteers recruited from up to 20 US sites with Pseudomonas aeruginosa airway colonization. The single dose of phage consists of a mixture of four anti-pseudomonal phages. Six sentinel participants will be sequentially enrolled with dose escalation of the phage mixture by one log

DISCUSSION: This trial will investigate the activity of phages in reducing P. aeruginosa colony counts …

Clinical Significance Of Glycolytic Metabolic Activity In Hepatocellular Carcinoma, Joann Jung, Sowon Park, Yeonwoo Jang, Sung-Hwan Lee, Yun Seong Jeong, Sun Young Yim, Ju-Seog Lee

Faculty, Staff and Student Publications

High metabolic activity is a hallmark of cancers, including hepatocellular carcinoma (HCC). However, the molecular features of HCC with high metabolic activity contributing to clinical outcomes and the therapeutic implications of these characteristics are poorly understood. We aimed to define the features of HCC with high metabolic activity and uncover its association with response to current therapies. By integrating gene expression data from mouse liver tissues and tumor tissues from HCC patients (n = 1038), we uncovered three metabolically distinct HCC subtypes that differ in clinical outcomes and underlying molecular biology. The high metabolic subtype is characterized by poor …

Ai In The Hands Of Imperfect Users, Kristin M Kostick-Quenet, Sara Gerke

Center for Medical Ethics and Health Policy Staff Publications

As the use of artificial intelligence and machine learning (AI/ML) continues to expand in healthcare, much attention has been given to mitigating bias in algorithms to ensure they are employed fairly and transparently. Less attention has fallen to addressing potential bias among AI/ML's human users or factors that influence user reliance. We argue for a systematic approach to identifying the existence and impacts of user biases while using AI/ML tools and call for the development of embedded interface design features, drawing on insights from decision science and behavioral economics, to nudge users towards more critical and reflective decision making using …

Pharmacokinetic Study Of Intranasal Dexamethasone And Methylprednisolone Compared With Intravenous Administration: Two Open-Label, Single-Dose, Two-Period, Two-Sequence, Cross-Over Study In Healthy Volunteers, Graciela Cárdenas, Raúl J. Bobes, Gladis Fragoso, Nicolas I. Pérez-Osorio, Marisela Hernández, Alejandro Espinosa, Agnes Fleury, José Flores, Juan Carlos Alvarenga, Juan Pedro Laclette

School of Medicine Publications

Dexamethasone (DXM) and methylprednisolone (MEP) are potent glucocorticoids used to control several inflammatory conditions. Evidence of delayed DXM reaching the central nervous system (CNS) as well as tachyphylaxis and systemic, undesirable side effects are the main limitations of peripheral delivery. Intranasal administration offers direct access to the brain as it bypasses the blood–brain barrier. The Mucosal Atomization Device is an optimal tool that can achieve rapid absorption into the CNS and the bloodstream across mucosal membranes. This study was designed to evaluate and compare the bioavailability of DXM and MEP after intranasal versus intravenous administration. Two open-label, balanced, randomized, two-treatment, …

Ramseyer, The Japanese Right-Wing And The “History Wars”, Tomomi Yamaguchi

Journal of International Women's Studies

J. Mark Ramseyer’s publications on the topics of wartime “comfort women” and Japan’s minorities have become the focus of intense controversy. His article on “comfort women” in the International Review of Law and Economics gained global scrutiny following its coverage in Japan’s right-wing newspaper, Sankei Shimbun, and its English-language publication, Japan Forward. Ramseyer claims that “comfort women” willingly entered into sex-work contracts, denying responsibility by Japan’s military and government for the “comfort station” system. He also insists that naming this system “sexual slavery” is “pure fiction” – a stance shared by Japanese history denialists in Japan. Since the controversy over …

Modified Ube3a Gene For A Gene Therapy Approach For Angelman Syndrome, Kevin Ron Nash, Edwin John Weeber, Jennifer Leigh Daily

USF Patents

Angelman Syndrome (AS) is a genetic disorder occurring in approximately one in every 15,000 births. It is characterized by severe mental retardation, seizures, difficulty speaking and ataxia. The gene responsible for AS was discovered to be UBE3A and encodes for E6-AP, an ubiquitin ligase. A unique feature of this gene is that it undergoes maternal imprinting in a neuron-specific manner. In the majority of AS cases, there is a mutation or deletion in the maternally inherited UBE3A gene, although other cases are the result of uniparental disomy or mismethylation of the maternal gene. While most human disorders characterized by severe …

Structure-Based Rational Design Of Small Α-Helical Peptides With Broad-Spectrum Activity Against Multidrug-Resistant Pathogens, Sandeep Lohan, Anastasia G. Konshina, Roman G. Efremov, Innokentiy Maslennikov, Keykavous Parang

Pharmacy Faculty Articles and Research

A series of small (7–12 mer) amphipathic cationic peptides were designed and synthesized to create short helical peptides with broad-range bactericidal activity and selectivity toward the bacterial cells. The analysis identified a lead 12-mer peptide 8b with broad-spectrum activity against Gram-positive (MIC = 3.1–6.2 μg/mL) and Gram-negative (MIC = 6.2–12.5 μg/mL) bacteria and selectivity toward prokaryotic versus eukaryotic cells (HC50 = 280 μg/mL, >75% cell viability at 150 μg/mL). The rapid membranolytic action of 8b was demonstrated by a calcein dye leakage assay and confirmed using scanning electron microscopy. According to circular dichroism and NMR spectroscopy, the peptides have an …

Taking Action: Turning Evolutionary Theory Into Preventive Policies, Orsolya Molnár, Marina Knickel, Christine Marizzi

MANTER: Journal of Parasite Biodiversity

The emerging infectious disease (EID) crisis has been challenging global health security for decades, dealing substantial damage to all socioeconomic landscapes. Control measures have failed to prevent or even mitigate damages from an accelerating wave of EIDs, leading to the emergence and devastation caused by the COVID-19 pandemic. In the wake of the pandemic, we must critically review our public health policies and approaches. Current health security measures are based on the evolutionary theorem of host-parasite coevolution, which falsely deems EIDs as rare and unpredictable. The DAMA protocol (Document, Assess, Monitor, Act) is nested in a novel evolutionary framework that …

Novel Therapeutic Nutrients Molecules That Protect Against Zika Virus Infection With A Special Note On Palmitoleate, Philma Glora Muthuraj, Chandan Krishnamoorthy, Ann Anderson-Berry, Corrine K. Hanson, Sathish Kumar Natarajan

Department of Nutrition and Health Sciences: Faculty Publications

Zika virus (ZIKV) is a Flavivirus from the Flaviviridae family and a positive-sense single strand RNA virus. ZIKV infection can cause a mild infection to the mother but can be vertically transmitted to the developing fetus, causing congenital anomalies. The prevalence of ZIKV infections was relatively insignificant with sporadic outbreaks in the Asian and African continents until 2006. However, recent epidemic in the Caribbean showed significant increased incidence of Congenital Zika Syndrome. ZIKV infection results in placental pathology which plays a crucial role in disease transmission from mother to fetus. Currently, there is no Food and Drug Administration (FDA) approved …

Scope Of Homoeopathy In The Treatment Of Depression: A Narrative Synthesis, Karunakara Moorthi, Radhika P, Manu Chandran, K.C. Muraleedharan

Indian Journal of Research in Homoeopathy

Background: Depression is a disorder of major public health importance, in terms of its prevalence and suffering, dysfunction, morbidity and economic burden. Depression is one of the most common conditions for which people seek homoeopathic treatment. Objective: This study is aimed to understand the scope of homoeopathy in depression based on the results of previous studies. Methods: A study was done to evince the scope of homoeopathic medicines in the treatment of depression. Searches were done in both general and specialised databases. The data were collected from peer-reviewed journals published between January 2001 and January 2021. Efforts …

Accuracy Of Covid-19 Relevant Knowledge Among Youth: Number Of Information Sources Matters, Patricia Wonch Hill, Judy Diamond, Amy N. Spiegel, Elizabeth Vanwormer, Meghan Leadabrand, Julia Mcquillan

Department of Sociology: Faculty Publications

Can comics effectively convey scientific knowledge about COVID-19 to youth? What types and how many sources of information did youth have about COVID-19 during the pandemic? How are sources of information associated with accurate COVID-19 knowledge? To answer these questions, we surveyed youth in grades 5–9 in a Midwestern United States school district in the winter of 2020–2021. The online survey used measures of COVID-19 knowledge and sources, with an embedded experiment on COVID-19 relevant comics. Guided by an integrated science capital and just-in-time health and science information acquisition model, we also measured level of science capital, science identity, and …

Pengaruh Penambahan Kromium Organik Pada Lemna Sp. Terhadap Pertumbuhan Ikan Gurami (Osphronemus Gouramy), Yuli Andriani, Iskandar Iskandar, Titin Herawati, Rusky I. Pratama

Chimica et Natura Acta

Lemna sp. merupakan tanaman air yang banyak tersebar di perairan umum di Indonesia, dan memiliki kandungan nutrisi yang baik sehingga berpotensi digunakan sebagai pakan ikan. Penelitian ini dilaksanakan di Kawasan Perikanan Darat Ciparanje FPIK Unpad, Balai Pengembangan dan Pemacuan Stok Ikan Gurame dan Nilem (BPPSIGN) Singaparna Tasikmalaya. Penelitian ini bertujuan untuk menganalisis pengaruh pemberian Lemna sp. berimbuhan kromium optimal untuk meningkatkan pertumbuhan benih ikan gurame. Penelitian dilakukan dalam dua tahap, tahap satu adalah mengukur retensi kromium dalam Lemna yang dikultur pada media yang mengandung krom 10 mg/L pada ketinggian air yang berbeda (10 dan 20 cm). Tahap dua adalah memberikan …

A Report Of Intraguild Predation By Orthochirus Sp. On Hottentotta Tamulus (Scorpiones: Buthidae) In Maharashtra, India, Mihir Joshi, Shubhankar Deshpande

Euscorpius

We report an event of intraguild predation by Orthochirus sp. feeding on a juvenile individual of Hottentotta tamulus (Fabricius,1798) from Maharashtra, India. This is the first report of intraguild predation among Indian scorpions.

Cesaire's Tempest Writes Back To The Empire, Sawsan Ahmad Daraiseh, Nancy Habis Al-Doghmi, Banan Ahmad Daraiseh

Association of Arab Universities Journal for Arts مجلة اتحاد الجامعات العربية للآداب

Aimé Césaire, who lived the experience of colonialism, wrote back to Shakespeare’s play The Tempest in a play of his own, which he called A Tempest. Unlike notions of A Tempest as a simplistic writing back, the current research reveals A Tempest as a sophisticated play in which Césaire uses his own creative methods, some of which incorporate the colonizer and others the colonized, to write back to the Empire which Shakespeare represents well and reflects. This research performs a deep analysis of A Tempest, revealing the voice of the Other as enabled; arguing with and disabling The Tempest’s deep …

New Worm On The Block: Planarians In (Neuro)Toxicology, Danielle Ireland, Eva-Maria S. Collins

Biology Faculty Works

Traditional mammalian testing is too time- and cost-intensive to keep up with the large number of environmental chemicals needing assessment. This has led to a dearth of information about the potential adverse effects of these chemicals, especially on the developing brain. Thus, there is an urgent need for rapid and cost-effective neurotoxicity and developmental neurotoxicity testing. Because of the complexity of the brain, metabolically competent organismal models are necessary to understand the effects of chemicals on nervous system development and function on a systems level. In this overview, we showcase asexual freshwater planarians as an alternative invertebrate (“non-animal”) organismal model …

Hearing Loss And Cortical Atrophy: A Case Study, Nithin Anand Kottikkulam, Sinju P. Kandathil, Badarunisa Mohamad Basheer

Manipal Journal of Medical Sciences

Background Cerebral atrophy results from the loss of neurons and their connections with the brain. As dementia progresses, an increasing number of neural connections die off. Brain atrophy may potentially damage hearing capacity through the impairment of primary and secondary auditory centres which are located in the temporal lobe. While there is no proven evidence or definitive evidence that hearing loss results in cognitive decline and mental health issues, there is definitely some connection and several clues that experts are looking into.Through this case report, the occurrence of ARHL with a mild dementia is been highlighted. Documenting such cases would …

Diverse Monogenic Subforms Of Human Spermatogenic Failure, Liina Nagirnaja, Wu-Lin Charng, Christina A Gurnett, Kenan R Omurtag, Et Al.

2020-Current year OA Pubs

Non-obstructive azoospermia (NOA) is the most severe form of male infertility and typically incurable. Defining the genetic basis of NOA has proven challenging, and the most advanced classification of NOA subforms is not based on genetics, but simple description of testis histology. In this study, we exome-sequenced over 1000 clinically diagnosed NOA cases and identified a plausible recessive Mendelian cause in 20%. We find further support for 21 genes in a 2-stage burden test with 2072 cases and 11,587 fertile controls. The disrupted genes are primarily on the autosomes, enriched for undescribed human "knockouts", and, for the most part, have …