Digital Commons Network^™

Improving The Perioperative Experience Of Patients And Families In A Pediatric Setting, Anjanette Pong

Student Scholarly Projects

Practice Problem: The experience of surgery for pediatric patients and their families can be dependent on multiple factors including adequate preparation, English language proficiency and realistic expectations. Anxiety can contribute to a negative experience that may result in poor outcomes and a damaging reflection of the healthcare team and organization.

PICOT: The PICOT question that guided this project was: In preoperative pediatric patients and their families, how do therapeutic communication style and the provision of information about the perioperative experience affect their healthcare experience over eight weeks?

Evidence: A multi-modal approach to providing tailored preoperative education for the child and …

Raising Native Plant Awareness As A Method For Re-Naturalization, Meredith L. Haaker

Social Sciences

Humans are inseparable from the natural environment. We are one and the same, interconnected within the ecology of creation and care, not only destruction. By grounding ourselves in Indigenous wisdom and the principles of Traditional Ecological Knowledge, we are more able to recognize the important relational facets between humans and three native Californian plants (California black walnut, California blue elderberry, California bay laurel). In introducing Kimmerer’s concept of re-naturalization of humans, we can draw a connection to the same process a naturalized plant undergoes; immigration from a foreign place, dependence on the surrounding resources, and settlement of an area …

Spatial Response Of Bobcats And Coyotes To Resources And Human Modification In Illinois, Nicole Gorman

Theses

Mesocarnivores, including bobcats (Lynx rufus) and coyotes (Canis latrans), fill a unique ecological role throughout much of North America, where they were once influenced by larger predators, but are now the top predators where large carnivores have been extirpated. Their adaptability, generalist traits, and ability to coexist with humans to a greater extent than many species makes them an important subject for current predator research. In addition, their recent population recovery in the case of bobcats and historical range expansion in the case of coyotes make their study timely given a potential increase in their influence on their prey and …

Tracing The Roots Of Resistance, Collective Action And Solidarity Among Igbo Women, Sebastian Ukoh

Theses

Most societies have always achieved balance through some internal mechanisms. Achieving gender balance and drawing lines without letting what we may term the "stronger sex" domineer the "weaker sex" is not always easy. Among the Igbos of South Eastern Nigeria, the women have always pressed home their demands without fear. We will be looking at how they have done this for more than a century, especially at the onset of the British colonial enterprise.

A Study Of The Effect Of Sympathetic Framing On Attitudes Toward The Homeless, Marshall Mills

Honors Capstones

No abstract provided.

Evaluating The Viscoelastic Properties Of Alligator Skin Gelatin, Alligel, Compared To Mammalian And Fish Gelatins, Sarah E. Jimenez

Honors Capstones

No abstract provided.

Ensemble Concerts: Symphonic Winds, December 1, 2022, F. Mack Wood

School of Music Programs

Center for the Performing Arts
December 1, 2022
Thursday Evening
8:00 p.m.

Understanding And Targeting The Immunosuppressive Tumor Microenvironment, Li Cai, Li Cai

Dissertations and Theses (Open Access)

Immune checkpoint inhibitors (ICIs), such as anti-PD1/PD-L1 and anti-CTLA-4, have shown impressive antitumor efficacy by improving the activity of T cells. While these inhibitors work in many patients with various cancer types, they have minimal or no effect in many more patients. Mounting evidence indicates that, besides current known immune checkpoints, other immunosuppressive components in the tumor microenvironment (TME) need to be targeted to elicit the full immune responses.

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of immunosuppressive myeloid cells that are involved in cancer progression and therapeutic resistance. In this work, we demonstrated the essential role of MDSCs …

The Adar-Mavs Pathway Is A Critical Mediator Of The Innate Immune System In Pancreatic Development And Cancer, Dhwani Rupani

Dissertations and Theses (Open Access)

Adenosine deaminase acting on RNA (ADAR) is an RNA-binding protein that deaminates adenosine (A) to inosine (I). A-to-I editing is an important post-transcriptional mechanism to prevent recognition of endogenous RNA by MDA5, a cytosolic RNA sensor. Activation of MDA5 by viral RNA can stimulate the innate immune system. Thus, ADAR-mediated RNA editing is crucial to distinguish “self” from “non-self”. ADAR has an important role in gene regulation as A-to-I editing alters RNA processing affecting both RNA and protein abundance. Given its importance in regulating innate immunity and transcript abundance, aberrations in Adar expression are implicated in developmental deformities and carcinogenesis. …

Bayesian Adaptive Clinical Trial Design, Mengyi Lu

Dissertations and Theses (Open Access)

The landscape of drug development in oncology has changed from conventional chemotherapies to molecular targeted therapies and immunotherapies, which provide innovative therapeutic modalities for treating cancers. These novel therapeutic agents work through mechanisms that fundamentally differ from standard chemotherapeutic agents, making the conventional trial design paradigm inefficient and dysfunctional. Specifically, the focus of dose-finding trials has shifted from finding the maximum tolerated dose (MTD) to the optimal biological dose (OBD), defined as the dose that optimizes the risk–benefit tradeoff. How to accurately identify the OBD and its dosing schedule is of great importance to maximize efficacy and safety of targeted …

Individual Differences In Lpp Amplitude And Theta Power Predict Cue-Induced Eating During A Cued Food Delivery Task, Kyla Gibney

Dissertations and Theses (Open Access)

Due to individual differences in the brain’s reward system, some individuals are more vulnerable than others to maladaptive, reward-seeking behaviors, such as substance use or compulsive eating. A body of research has demonstrated that individuals who attribute higher levels of incentive salience to reward-associated cues than to pleasant images (termed “C>P group” throughout) are more vulnerable to compulsive eating than those who attribute higher incentive salience to pleasant images than reward- associated cues (P>C group). Meanwhile, a separate body of research has demonstrated that cognitive control also regulates eating by enabling top-down attentional control. This dissertation aims to …

Risk-Factor Induced Changes In The Breast Microenvironment Facilitate Inflammatory Breast Cancer Progression And Lymphovascular Invasion, Wintana Balema, Wintana Balema

Dissertations and Theses (Open Access)

Inflammatory breast cancer (IBC) is a rapidly progressing, rare and highly lethal form of breast cancer. IBC is a clinical diagnosis, requiring >1/3 involvement on the affected breast and/or skin by erythema, and disease onset of < 6 months. The clinical symptoms of IBC vary in severity and presentation, these include redness, warmth, skin thickening and bruised or pink/purple discoloration appearance and skin changes such as peau d’orange. These skin symptoms are not attributed to inflammation, rather IBC is characterized by florid lymphovascular tumor emboli clogging dermal lymphatics. This leads to “classic” symptoms of breast swelling and skin edema or discoloration. To date, unique genomic drivers which differentiate IBC from non-IBC invasive breast cancers have not been identified highlighting a role for the microenvironment. Several epidemiological studies have unveiled subtype-specific risk factors associated with IBC that are known to alter the microenvironment. Obesity is an established risk factor for all subtypes of IBC. Never-breastfeeding increases risk for developing the most aggressive, triple-negative IBC. Further, never breastfeeding is associated with later clinical stage and worse outcomes. We worked to model these overlapping risk factors to understand microenvironment changes that may lead to the lymphatic change’s indicative of IBC.

First, we investigated the association of a “classic” triad of clinical IBC signs with overall survival among patients to demonstrate the most overt clinical findings of lymphatic involvement were impacting prognosis. We evaluated a triad of IBC signs, including swollen involved breast, nipple change, and diffuse skin change, using breast medical photographs from patients enrolled on a prospective IBC registry. We reported that the …

Ankyrin Dependent Mitochondrial Function And Bioenergetics In The Heart, Janani Subramaniam, Janani Subramaniam

Dissertations and Theses (Open Access)

ANK2 mutations in patients are associated with numerous arrhythmias, cardiomyopathies, and other heart defects. In the heart, AnkB, the protein encoded by ANK2, clusters relevant ion channels and cell adhesion molecules in several important domains; however, its role at Mitochondria Associated ER/SR Membranes (MAMs) has yet to be investigated. MAMs are crucial to mitochondrial function and metabolism and are signaling hubs implicated in various cardiac pathologies. Among several functions, these sites mediate the direct transfer of calcium from the ER/SR to the mitochondria to modulate ATP synthesis. Given that mitochondrial function and energy production are paramount to cardiovascular heath, …

Chesapeake Governance Study: Report Of 2021 Decision Maker Interview Results, D.G. Webster

Dartmouth Scholarship

This report describes the aggregate results from a series of interviews conducted with decision makers involved in governance of the Chesapeake Watershed. Interviews began in June and ended in December of 2021. Information collected will be combined with other data to create and then test a computer model to predict likely policy changes under a range of future scenarios. It is part of a larger project funded by the National Science Foundation called Modeling the Dynamics of Human and Estuarine Systems with Regulatory Feedbacks (Award #2009248). Using the Chesapeake Bay as an example, this project will combine the policy model …

Shelf-Life Extension And Campylobacter Jejuni Inhibition By Application Of Zinc Oxide Nanoparticles In Chicken Fillets, Amina Elrais, Reyad Rabea, Wlaa Abdel Megid, Mona Abdallah, Walid Sobhy Arab

Mansoura Veterinary Medical Journal

Because of its unique physical and chemical features, zinc oxide can be considered a versatile material. Campylobacter jejuni was intentionally inoculated into broiler breast fillets, and the practical application of zinc oxide nanoparticles (ZnO NPs) suspension with varying concentrations (5 mM and 10 mM) with 3 different sizes (25 nm, 50 nm, and 75 nm) for each concentration was examined. The results showed that ZnO suspensions had a strong inhibitory effect on Campylobacter jejuni growth after 8 days in the refrigerator at 4°C. When compared to other concentrations of 5 mM, ZnO NPs, 10 mM demonstrated the largest reduction percentage …

Molecular Characterization Of Some Pathogenic Bacterial Strains And Hematobiochemical Profile In Barki Sheep With Diarrhea In Siwa Oasis, Amani A. Hafez, Mohamed T. Ragab, Marwa A. Fawzy, Adel M. El-Kattan, Ahmed A. Elsayed

Mansoura Veterinary Medical Journal

Objective: To explore the incidence of several bacterial enteropathogens in Barki sheep with diarrhea and their antimicrobial resistance (AMR) trends and their hematobiochemical alteration in Siwa Oasis.Design: Descriptive study.Animals: A total of 500 adult Barki sheep were allocated into two equal-sized groups: 250 Barki ewes with diarrhea and 250 normal sheep taken as the control group. 250 faecal samples were taken from sheep with diarrhea. The bacterial enteropathogens were extracted, identified biochemically and determined using polymerase chain reaction (PCR). The Kirby-Bauer Disk-Diffusion Method was used to determine the sensitivity of positive samples from each organism to ten antimicrobials. Blood samples …

Effect Of Protein Reduction With Indispensable Amino Acid Supplementation At Different Levels In Practical Diets Of Nile Tilapia (Oreochromis Niloticus) Fish., Sara Youssef, Shimaa Salem, Rania Mahmoud, Tarek Ibrahim

Mansoura Veterinary Medical Journal

Objective: To estimate the effect of reducing dietary protein levels in Nile tilapia (Oreochromis niloticus) with dietary supplementation of commercially-available synthetic amino acids at different levels on growth performance, whole-body composition, morphometric indices, and serum metabolites.Design: Randomized controlled experimental study.Animals: One hundred eighty male Nile tilapia fingerlings.Procedures: One hundred eighty male Nile tilapia fingerlings were equally distributed in twelve glass aquaria (15 fish per aquarium) and fed the formulated diets at 4-5% of the body weight. Every two weeks, tilapia were weighed and the amount of feed intake was adjusted according to the increase in the tilapia weight. Results: By …

The Importance Of Hand Motions For Communication And Interaction In Virtual Reality, Alex Adkins

All Dissertations

Virtual reality (VR) is a growing method of communication and play. Recent advances have enabled hand-tracking technologies for consumer VR headsets, allowing virtual hands to mimic a user's real hand movements in real-time. A growing number of users now utilize hand-tracking when using VR to manipulate objects or to create gestures when interacting with others. As VR grows as a tool and communication platform, it is important to understand how the rising prevalence of hand-tracking technology might affect users' experiences.

The goal of this dissertation is to investigate, through a series of experiments, how using hand motions in VR influences …

Behavioral Ecology Of The American Alligator (Alligator Mississippiensis) In Human-Dominated Landscapes Of Coastal South Carolina, Anjelika Kidd-Weaver

All Dissertations

When wildlife habitat is developed to accommodate growing human populations, wildlife are forced to move to undisturbed landscapes or to acclimate to a novel, anthropogenic environment. In this dissertation, we investigated the behavior and ecology of the American alligator (Alligator mississippiensis) in coastal, residential resort communities with an overarching goal of identifying behavioral patterns of alligators that can inform risk management strategies. In Chapter One, we compared the space use of male and female alligators in primarily wetland versus residential landscapes across three seasons to determine if and how space use behaviors of alligators differ. We found that …

Highly Adherent Antimicrobial Coatings For Orthopedic Implants, Mikhail Bredikhin

All Dissertations

Fracture-related infections (FRIs) are the most devasting sort of complications associated with fracture fixation devices, as they lead to patients’ morbidity, prolonged hospitalization, amputations, and even death.External fixators additionally suffer from pin site infections (PSIs), which initiate at the skin entry points of the skin-metallic pin interface present in the external fixation of the damaged bones, often causing deep tissue infection and osteomyelitis. Small percutaneous pins, commonly known as Kirschner wires (K-wires), are used to treat complex fractures and deformities.They are drilled inside the diseased bone for the healing period and are left protruding outside the skin for fixation adjustments …

The Role Of Fatty Acid Metabolism In The Pathogenesis Of Trypanosoma Brucei, Nava Poudyal

All Dissertations

Trypanosoma brucei is the protozoan parasite that causes African Sleeping Sickness in humans and nagana, a wasting disease in cattle. T. brucei completes its life cycle in two hosts, mammals and the tsetse fly insect vector. Due to the geographical restriction of the tsetse fly, the disease is endemic in sub-Saharan Africa. Both the insect and mammalian forms of the parasite need fatty acids to anchor their surface proteins. We worked on three projects on fatty acid metabolism and its role in immune evasion strategies of T. brucei. First, we assessed the role of T. brucei surface proteins in …

Metabolic Engineering Of Yarrowia Lipolytica For Enhanced Peroxisomal Production Of Polyhydroxyalkanoates, Michael Spagnuolo

All Dissertations

Traditional chemical processes are made inefficient by the generation of side products and reactions that fail to reach completion. Bioprocesses, on the other hand, lose product potential due to the necessity of growing the organism required to produce the desired compounds. The field of metabolic engineering often seeks to alter this balance between product formation and cell growth to generate more product from the same quantity of feed (reagent). In addition to balance, such organisms may also be engineered to produce the desired products from nontraditional substrates, such as waste compounds. In resource-poor environments, the ability to produce a wanted …

Exploring Soil-Tree Interactions After Applying Organic Matter Amendments To Peach Orchards In The Subtropical Climate Of The Southeastern United States, Brian Lawrence

All Dissertations

Soil disturbance from the cultivation and intensive management of orchards in hot and humid subtropical climates can reduce soil organic matter (OM). This research explored how the addition of OM amendments impact soil and tree parameters in two field studies and how proximity to OM may elicit unique genomic response of peach roots in a split-root pot study. The first field study applied two rates of compost (1x and 2x) and subsequently reduced fertilizer applications annually to a virgin and replant orchard location. While both compost rates successfully replaced fertilizers, only the 2x rate in the replant location increased soil …

Ligand-Promoted Dissolution Of Uranyl Phosphate Across Scales, Brennan Ferguson

All Dissertations

The formation of uranyl phosphate precipitate is a remediation strategy because the low solubility of uranyl phosphate minerals, like chernikovite, limits the mobility of uranium in contaminated soils. However, organic ligands can complex with aqueous metal cations to form more soluble species. For example, citrate is a commonly occurring organic ligand produced by plants and microbes that increases the solubility of uranium and therefore the dissolution of uranyl phosphate minerals in the uranyl phosphate-citrate system. This effect is an important control on the mobility of uranium in organic-rich, and near-surface vegetated environments. Nevertheless, key aspects of the citrate-uranyl phosphate system …

Machine Learning Solutions For Biomedical Applications, Madeleine St. Ville

All Dissertations

This dissertation proposes three novel Bayesian modeling techniques to addresses the challenges arising from the complex, underlying features of biomedical data. These models are motivated by three different biomedical studies. The first is an analysis of data collected from six efficacy and safety clinical trials of buprenorphine maintenance treatment for opioid use disorder. The focus of this study is to overcome the problem of non-adherence by trial participants that, if left unaccounted for, obscures the true effect of buprenorphine on illicit opioid use. The second study is the assessment of hemodialysis cannulation skill through the use of a sensor-based simulator …

The Speculative Artifact 2022, Students Of Risd, Risd Archives

All Student Newspapers

The Speculative Artifact was a student publication created for the Graphic Design seminar/studio Critical Issues Studio, taught by Anther Kiley in Fall 2022. The publication features designs and concepts for artifacts of the future created by students. Artifacts include language aids, a sex worker kit, food packaging, a garden pack, style-transferred furniture, a post-taste apartment, a maze sculpture, a personality magazine, animal-human cohabitation, signage, a friend-dating system, coding tech, a transhuman sticker book, and television programming with animal languages

Estimation Of Disaggregated Import Demand Functions For Nigeria, Chekwube V. Madichie, Uche C. Nwogwugwu, Franklin N. Ngwu, Olisaemeka D. Mauka

CBN Journal of Applied Statistics (JAS)

This paper estimates disaggregated import demand function for Nigeria using annual data from 1970 to 2019. The study employs the Zivot-Andrews unit root and Gregory-Hansen cointegration tests to account for the role of structural breaks and the error correction mechanism for shortrun analysis, respectively. The results show that household consumption, industrial output and domestic investment are the major determinants of import demand for consumer, intermediate and investment goods, respectively. Furthermore, the import demand for investment goods is not sensitive to variations in relative prices. However, relative prices is negative and significant to import demand for consumer and intermediate goods. Exchange …

Trade And Transfer Of Environmentally Sound Technology In Asean: Mapping Priorities To Economic Treaty Negotiations, Locknie Hsu

Research Collection Yong Pung How School Of Law

The 10 members of the Association of Southeast Asian Nations (“ASEAN”) share common objectives in economic, sociocultural and political-security integration. Addressing environmental concerns is animportant consideration which traverses different areas of integration policymaking. ASEAN has, in recent years, emphasised the importance of environmental considerations, including environmentally sound technologies (“ESTs”) which may contribute to its climate change mitigation and adaptation efforts, in its law and policymaking. This article discusses the nexus between ASEAN’s needs for the transfer of ESTs and the group’s economic treaty negotiations. Through a “mapping” of such needs to free trade agreementareas, it aims to provide a pathway …

Heat Waves And A Public-Private Partnership In Alaska, Sarah A. Matsumoto, Karen Sandrik

Publications

No abstract provided.

Fragments And Foreignness In Claudia Rankine's Citizen, Cutter Mendenhall

Criterion: A Journal of Literary Criticism

This analysis investigates Claudia Rankine’s redefinition of foreignness as the fragmenting force of microaggressions that splinters the African American identity. This fragmentation has implications that shatter and reconstruct the traditional understanding of the African American self, the source and fallacies of both white and black anger, and what it means to be native to mainstream American society. Ultimately, Rankine asserts that the foreignizing nature of microaggressions is a socially constructed form of oppression. This foreignness breaks the African American identity into easily accessible subhuman caricatures that leave the black identity in a ruptured state of cognitive dissonance. While making coherence …