Digital Commons Network^™

Examining The Effects Of Npra Antagonist Anantin On Sci-Induced Ployuria., Lindsey Zipperer

Electronic Theses and Dissertations

Polyuria, or the over production of urine, is a prevalent condition that significantly impacts the quality of life in individuals suffering from a spinal cord injury (SCI). Post-SCI induced polyuria is thought to have been associated with altered levels of vasopressin (AVP), atrial natriuretic peptide (ANP), and natriuretic peptide receptor A (NPRA). In the present study, the function of NPRA was analyzed in the rat contusion model using anantin, an NPRA antagonist. A daily dose of either 100 µg of anantin or vehicle was administered intraperitoneally immediately following the SCI surgery and continued until termination, 4 weeks post injury (wpi). …

Foreign Policy In Media: An Examination Of The Captain America Films., Kat Hernandez

Electronic Theses and Dissertations

Popular culture and media are consumed daily by billions around the world, media which can contain meaningful and politically relevant material. The three Captain America films from the 2010s represent this phenomenon in the presentation of Captain America as a nationalist superhero with geopolitically relevant storylines. The direction and production of these films illustrate significant parallels to foreign policy choices of the United States. Through an interpretive analysis of the Captain America films: Captain America: The First Avenger, Captain America: The Winter Soldier, and Captain America: Civil War, this project seeks to analyze Captain America’s image and …

The Effect Of Volatile Organic Compounds On Endothelial Function And Atherogenesis., Samantha Mcfall

Electronic Theses and Dissertations

Volatile organic compounds (VOCs) are a group of pervasive air pollutants that are released into the atmosphere from both anthropogenic and environmental sources. Recent epidemiological studies suggest that exposure to various VOCs is associated with an increased risk of cardiovascular disease. However, the relationship between VOCs and cardiovascular disease is not well-studied. Using animal models and three select VOCs, benzene, xylene, and trichloroethylene, we studied the effects of VOCs on endothelial injury and benzene-induced atherogenesis. We found that exposure to benzene and xylene increased circulating endothelial microparticles, depleted progenitor cells, and increased platelet activation. Following the exposure to the representative …

The Role Of Mmp-3 In Copper Oxide Nanoparticle-Induced Pulmonary Inflammation And Fibrosis., Yuanbao Zhang

Electronic Theses and Dissertations

Copper oxide nanoparticles (Nano-CuO) are wildly used in medical and industrial fields and our daily necessities. However, the biosafety assessment of Nano-CuO is far behind their rapid development. This study was to investigate the potential mechanisms underlying Nano-CuO-induced pulmonary inflammation and fibrosis, especially to determine whether Nano-CuO exposure could dysregulate MMP-3, an important mediator in pulmonary fibrosis, and its roles in Nano-CuO-induced pulmonary inflammation and fibrosis. Aim 1 was to investigate whether exposure to Nano-CuO caused MMP-3 dysregulation in lung epithelial cells and the role of MMP-3 in Nano-CuO-induced alteration of cell junction-associated proteins. The potential mechanisms that might be …

Hgf-Mediated C-Met Signaling In Human Corneal Epithelial Cells., Kate Tarvestad

Electronic Theses and Dissertations

Vision is often regarded as the primary sense of humans. The cornea is the main refractive tissue that permits light through to the retina, allowing a clear image. When the cornea sustains damage, it opens a pathway for infection and blindness through fibrotic processes. Healing the corneal tissue is critical for vision restoration and pain alleviation. Growth factors and their cognate receptors are currently under investigation as tools to restore proper corneal physiology. We hypothesize that manipulating the hepatocyte growth factor (HGF)/ c-Met signaling pathway is one route to promote quality corneal healing. This thesis investigates the signaling, trafficking, and …

The Student Movement Volume 107 Issue 10: Finals Week Is About To Get Messi, Gloria Oh, Nora Martin, Amelia Stefanescu, Solana Campbell, Abraham Bravo, Ceiry Flores, Hannah Cruse, Andrew Francis, Bella Hamann, Gabriela Francisco, Valerie Akinyi, Ruben Colón, Charisse Lapuebla, Alannah Tjhatra

The Student Movement v. 107 (2022-2023)

HUMANS

Introducing Active Minds Club, Gloria Oh

Women in STEM: Bia Martins, Interviewed by: Nora Martin

Women in STEM: Davielle Smith, Interviewed by: Gloria Oh

ARTS & ENTERTAINMENT

Art Majors at AU: Graphic Design, Amelia Stefanescu

Currently..., Solana Campbell

Immersed in a Musical Wonderland, Abraham Bravo

What did AU Watch over Break?. Ceiry Flores

NEWS

Act 22 and Statehood: What is the Answer to Puerto Rico's problems?, Hannah Cruse

AU Abroad "Shark Tank" Winners Prepare for Spring Start, Andrew Francis

Student Debt Cancellation: Updates and Thought, Gloria Oh

IDEAS

From Cover to Cover: Braking out of the Adventist Bubble, Bella …

Neurological Manifestations Of Cerebral Venous Thrombosis: Experience From A Tertiary Care Center, Anum Irfan, Soban Khan, Zaid Waqar, Sumaira Nabi, Bushra Khalid, Muhammad Tariq

Pakistan Journal of Neurological Sciences (PJNS)

Background and objective: Cerebral venous thrombosis (CVT) is a common cause of cerebrovascular accident (stroke). CVT is caused due to blockage in blood flow either in cerebral veins or in dural sinuses. The objective of this study was to determine prevalence of various clinical and imaging characteristics in patients with cerebral venous thrombosis.

Methods: A descriptive retrospective cross-sectional patient data was collected from November 2019 to February 2021. This study was conducted in Neurology Department in Pakistan Institute of Medical Sciences (PIMS), Islamabad, Pakistan. This study contains patient medical histories of 60 patients who were admitted in two and a …

Taxonomic Species Recognition Should Be Consistent, Stephen James O'Brien, Shu-Jin Luo

Biology Faculty Articles

No abstract provided.

Diagnosing Covid-19 Infection In Chest X-Ray Images Using Neural Network, Salim M. Zaki, Mustafa Musa Jaber, Mohammed A. Kashmoola

Baghdad Science Journal

With its rapid spread, the coronavirus infection shocked the world and had a huge effect on billions of peoples' lives. The problem is to find a safe method to diagnose the infections with fewer casualties. It has been shown that X-Ray images are an important method for the identification, quantification, and monitoring of diseases. Deep learning algorithms can be utilized to help analyze potentially huge numbers of X-Ray examinations. This research conducted a retrospective multi-test analysis system to detect suspicious COVID-19 performance, and use of chest X-Ray features to assess the progress of the illness in each patient, resulting in …

High-Intensity Interval Training And Biological Age, Trevor Lohman

Loma Linda University Electronic Theses, Dissertations & Projects

The emergence of valid predictors of biological age has enabled researchers to test the effects of various interventions on biological aging processes. The established virtues of exercise and its effects on health and longevity make it a suitable candidate for investigation. This dissertation reviews the current state of biological age prediction models and presents a trial in which a specific exercise protocol’s ability to modulate biological age is tested. The specific protocol used is a 10X1 high-intensity interval training (HIIT) protocol, 10X1 referring to the quantity and duration of high intensity exercise intervals in each exercise session. The specific biological …

The Role Of The Filifactor Alocis Hypothetical Protein Fa1654 In Oxidative Stress Resistance, Malissa Makaylia Mangar

Loma Linda University Electronic Theses, Dissertations & Projects

The survival/adaptation of Fillifactor alocis, a fastidious gram positive asaccharolytic anaerobe in the inflammatory environment of the periodontal pocket, requires an ability to overcome oxidative stress. Moreover, emerging observations suggest its pathogenic characteristics are highlighted by its capacity to survive in the oxidative-stress microenvironment of the periodontal pocket and its likely ability to modulate the microbial community dynamics. There is still a significant gap in our understanding of F. alocis mechanism of oxidative stress resistance and its impact on the virulence and pathogenicity of the microbial biofilm. The pathogenicity of F. alocis may be impacted by its response to oxidative …

Med12 Is A Critical Regulator Of Neural Crest Lineage And Nervous System Myelination, Fatma Betul Aksoy Yasar

Dissertations and Theses (Open Access)

The Mediator complex (MED) is a multi-subunit protein complex integral to the eukaryotic transcription machinery. MED12 is a Cdk8- regulatory kinase module subunit directly implicated in human disease and is genetically altered in neurological disease and cancer. Numerous attempts at generating an in vivo system to study the role of Med12 failed due to embryonic lethality associated with germline or developmental disruption of Med12 gene. To understand the cellular and molecular processes associated with its role in disease, we generated multiple mouse models with targeted depletion of MED12 in distinct cellular lineages. Our genetically engineered models with induced and conditional …

Pop & Perjury: The Irs Valuation War With The Estate Of Michael Jackson

The University of New Hampshire Law Review

When Michael Jackson died unexpectedly in Los Angeles, California, on June 25, 2009, his career and earnings were nearing an all-time low. Plagued by past sexual abuse allegations, scandals, and questionable health, Michael Jackson’s personal finances were purported to be in complete disarray. However, following his unexpected death, the value of his estate, which was reported to be near to nothing, swelled as the world remembered his beloved contributions to the world and began to purchase accordingly. Sales of Michael Jackson’s music began to soar high. The estate’s value soared even higher as it signed licensing agreements and released new …

Undead Dicta Or Haunted Holdings? A Closer Look At The Zombie Subjective Intent Partnership Formation Cases

The University of New Hampshire Law Review

Undead precedents haunt the partnership formation caselaw. But just how dangerous are they? It depends on what type of zombies they are—walking-dead dicta or haunted holdings. Asking a court to ignore bad dicta is nowhere near as difficult for litigants as asking a court to overrule an entire line of cases.

This article takes a closer look at the undead partnership formation cases that were previously identified in a companion article and concludes that nearly all such cases fall into the less-scary category of undead dicta, rather than truly dangerous category of zombie holdings.

Virtual Art And Non-Fungible Tokens, Lawrence J. Trautman

Hofstra Law Review

Fueled in part by the wealth recently created from digital currencies, major art dealers such as Christie's and Sotheby's have embraced the sale of non-fungible tokens attached to unique digital works of art. What are non-fungible tokens, how is this related to the blockchain, and what do we know about this rapidly evolving market for digital art? It appears that digital art can be added to the growing list of uses for blockchain technology now becoming a part of modern life. This Article proceeds in seven Parts. First is a discussion about the new and explosive market for digital art. …

Bobcat Identification, Abundance, And Behavior At Road Mitigation Structures In South Texas, Victoria Hanley

Theses and Dissertations

Highways in South Texas fragment the landscape and result in high road mortality rates for the endangered US ocelot (Leopardus pardalis). In response, the Texas Department of Transportation constructed nine wildlife crossing structures (WCS) on Farm-to-Market (FM) 106 which adjoins Laguna Atascosa National Wildlife Refuge in Cameron County, Texas. With ocelots being rare and elusive, bobcats (Lynx rufus) are often used as a surrogate species to study felid behavior at road mitigation structures in South Texas. Bobcats have unique markings which allow them to be individually identified. Three methods of individual identification of bobcats using camera …

Geology, Soils And Climate Of Western Australia's Wine Regions, Peter J. Tille, Angela Stuart-Street, Peter S. Gardiner

Bulletins 4000 -

This bulletin details what is special and unique about the geology, soil and climate of the south-west of Western Australia (WA), an area that encompasses the state’s 9 wine regions.

We have arranged the information into 2 parts:

• In Part 1, we broadly describe the special geological, soil and climate features of the south-west of WA to provide context for the wine regions.

• In Part 2, we describe the geology, soil and climate of the regions and subregions of the Geographical Indications (GI) scheme (administered by Wine Australia) for WA.

Through this work we have found that the wine regions …

Evolutionary Cartographies Of Language Diversification: Quantitative Approaches To The Geolinguistic Mapping Of The Kayanic Languages (Central Borneo), Deandré A. Espree-Conaway

Theses and Dissertations

Why are there so many languages in the world and how did this diversity come about? Every day, humans around the world speak over 7,000 languages. One of the most impactful theories describing the processes and mechanisms of language diversification is that of the Linguistic Niche Hypothesis (Lupyan & Dale 2010). The Linguistic Niche Hypothesis suggests that languages adapt to their environments (Lupyan & Dale 2010: 1). Lupyan and Dale describe it, stating that "just as biological organisms are shaped by ecological niches, languages structures...adapt to the environment (niche) in which they are being learned and used" (2010: 1). Taking …

Stimulus Discrimination Training And Its Effects On Generalization Gradients, Christopher Veenstra

Theses and Dissertations

Adaptation-level theory has been used to explain how the size and shape of generalization gradients depend on the procedure used to study generalization. However, most of the empirical support for this theory has come from studies using a relatively simple stimulus dimension (e.g., lights that vary in brightness). In addition, much of the research has focused on one specific prediction of adaptation-level theory: that responding during a generalization test should shift towards intermediate values within the tested portion of the stimulus dimension. The present research used a more complex set of stimuli. Specifically, the stimulus dimension was based on bar …

Molecular Characterization Of Potential Crop Pathogens Associated With Weeds As Endophytes In Uniilorin Plantations, Nigeria, A. A. Lateef, T. Garuba, K. A. Abdulkareem, B. U. Olayinka, G. S. Olahan, S. B. Adeyemi, A. A. Abdulrahaman

Baghdad Science Journal

Crop diseases are usually caused by inoculum of pathogens which might exist on alternate hosts or weeds as endophytes. These endophytes, cum pathogens, usually confer some beneficial attributes to these weeds or alternate hosts from protection against herbivores, disease resistance, stress tolerance to secondary metabolites production. This study was therefore carried out to isolate potential crop pathogens which exist as endophytes on weed species in the University of Ilorin plantations. Green asymptomatic leaves were collected from 10 weed species across the plantations, and processed for their endophytic fungi isolation. Isolates were purified into pure cultures and used for molecular identification …

The Little Shepherd, James C. Schaap

Pro Rege

No abstract provided.

Prenatal Opioid Use And Neonatal Abstinence Syndrome: A Review Of The Neurophysiological, Neuropsychological, And Behavioral/Emotional/Social Impacts In The Pediatric Population, Candice Gore

Dissertations

The opioid epidemic over the past two decades has raised concerns regarding the developmental fetal impact of prenatal opioid use. Research in this area continues to grow, but largely has focused on treatment for neonates experiencing withdrawal symptoms postnatally. Long term clinical implications for this at-risk population have not been studied extensively leaving many gaps in research and highlighting the need for future empirical studies. This literature review will examine the neurophysiological, neuropsychological, and the behavioral/social/emotional impacts on infants, toddlers, and school aged children who were prenatally exposed to opioids with or without the diagnosis of neonatal abstinence syndrome. Providing …

Lifestyle Choices Related To Food Consumption And Their Relationship To Depression, Steven L. Jennings Jr.

Dissertations

Dieting, or the act of restricting oneself to small amounts or particular kinds of foods on the basis of health, spirituality, lifestyle, and moral decisions, is a practice that dates to 1066 A.D. However, with social media being as influential as it is, one might believe dieting is a new obsession or at least an obsession to which popular culture is returning. Despite this, it is only in recent years that researchers have begun to focus on the health benefits of such behaviors. The present study was designed to take this focus a step further by exploring the potential risks …

Streaming Gender, Masculinity, And Race: Luke Cage's Impact On The Marvel Cinematic Universe, Samual Madison Mcmillen

Graduate Theses and Dissertations

Streaming Gender, Masculinity, and Race: Luke Cage’s Impact on the Marvel Cinematic Universe analyzes gender, masculinity, and race in Marvel’s transmedia universe. The analysis examines streaming television’s role in confronting social issues related to gender, masculinity, and race, such as systemic racism, white supremacy, and toxic masculinity. This study examines the impact of three Netflix series on the Marvel Cinematic Universe, Luke Cage, Jessica Jones, and The Defenders, as these series were Marvel’s initial use of streaming television. The character, Luke Cage, appears in each of these Netflix series, and while each series tells a story of its own, the …

Effects Of Small Molecule Fak Activators On Gastrointestinal Mucosal Healing, Sema Oncel

Theses and Dissertations

Gastrointestinal (GI) ulcers are common worldwide. The persistence of noxious agents such as gastric acid, pepsin, nonsteroidal anti-inflammatory drugs (NSAIDs), and inflammation caused by inflammatory bowel disease breaks down the mucosal barrier and causes mucosal injury in the GI tract. Currently available therapeutics such as proton pump inhibitors (PPIs), histamine-2 receptor antagonists (H2-antagonists), antibiotics, and corticosteroids all attempt to minimize injury by reducing the symptoms of GI pathology, however, they do not directly promote mucosal healing. NSAIDs increase the development of both upper and lower GI ulcers. PPIs ameliorate upper GI injury; however, PPIs actually worsen NSAID distal enteropathy by …

Rsv-Induced Actin Modulation: Contributes To Bronchial Wall Thickening; Does Not Induce Emt, And Is Cdc42-Assisted, Sattya Narayan Talukdar

Theses and Dissertations

RSV is a negative-sense, single-stranded RNA virus that infects our respiratory tract and can cause severe bronchiolitis and pneumonia worldwide. RSV bronchiolitis causes more fatalities in infants and newborns and leads to severe hospitalization and even death of children. The host-RSV interaction has yet to be explored properly to explain RSV bronchiolitis. This study aimed to elucidate the connection between the modulation of host actin cytoskeletal with viral pathogenesis, including bronchiolitis. As bronchial wall thickening is a common feature of bronchiolitis, the contribution of RSV-infected airway epithelium to bronchial wall thickening was evaluated. RSV infection in the healthy adult bronchial …

Multispectral Imaging For Microchip Electrophoresis Enables Point-Of-Care Newborn Hemoglobin Variant Screening, Ran An, Yuning Huang, Anne Rocheleau, Qiaochu Zhang, Yuncheng Man, Zoe Sekyonda, Amma Owusu-Ansah, Umut A. Gurkan

Faculty Scholarship

Hemoglobin (Hb) disorders affect nearly 7% of the world's population. Globally, around 400,000 babies are born annually with sickle cell disease (SCD), primarily in sub-Saharan Africa where morbidity and mortality rates are high. Screening, early diagnosis, and monitoring are not widely accessible due to technical challenges and cost. We hypothesized that multispectral imaging will allow sensitive hemoglobin variant identification in existing affordable paper-based Hb electrophoresis. To test this hypothesis, we developed the first integrated point-of-care multispectral Hb variant test: Gazelle-Multispectral. Here, we evaluated the accuracy of Gazelle-Multispectral for Hb variant newborn screening in 265 newborns with known hemoglobin variants including …

Application Of A Neutrosophic Soft Set Model To Animal Abandonment And Its Consideration As Mistreatment, Esperanza Del Pilar Araujo Escobar, Juan Carlos Arandia Zambrano, Carlos Fernando Soria Mesías, Jorge Alfredo Eras Díaz

Neutrosophic Sets and Systems

No abstract provided.

Treatment Alternatives To Gingival Hyperpigmentation Using Neutrosophic Correlation Coefficients, Fernando Marcelo Armijos Briones, José Israel Castillo González, Jaime Fernando Armijos Moreta, Catalina Del Rosario Boada Zurita

Neutrosophic Sets and Systems

No abstract provided.

Analysis Of Per Capita Contributions From A Spatial Model Provides Strategies For Controlling Spread Of Invasive Carp, Donald R. Schoolmaster Jr., Alison A. Coulter, Jahn L. Kallis, Donald C. Glover, John M. Dettmers, Richard A. Erickson

Natural Resource Management Faculty Publications

Metapopulation models may be applied to inform natural resource management to guide actions targeted at location-specific subpopulations. Model insights frequently help to understand which subpopulations to target and highlight the importance of connections among subpopulations. For example, managers often treat aquatic invasive species populations as discrete populations due to hydrological (e.g., lakes, pools formed by dams) or jurisdictional boundaries (e.g., river segments by country or jurisdictional units such as states or provinces). However, aquatic invasive species often have high rates of dispersion and migration among heterogenous locations, which complicates traditional metapopulation models and may not conform to management boundaries. Controlling …