Digital Commons Network^™

A Suggested Data Structure For Transparent And Repeatable Reporting Of Bibliographic Searching, Neal R. Haddaway, Melissa L. Rethlefsen, Melinda Davies, Julie Glanville, Bethany Mcgowan, Kate Nyhan, Sarah Young

Publications

Academic searching is integral to research activities: (1) searching to retrieve specific information, (2) to expand our knowledge iteratively, (3) and to collate a representative and unbiased selection of the literature. Rigorous searching methods are vital for reliable, repeatable and unbiased searches needed for these second and third forms of searches (exploratory and systematic searching, respectively) that form a core part of evidence syntheses. Despite the broad awareness of the importance of transparency in reporting search activities in evidence syntheses, the importance of searching has been highlighted only recently and has been the explicit focus of reporting guidance (PRISMA-S). Ensuring …

Food Security & Urban Agriculture - Considerations For Soil Improvements And Crop Planning, Aaron Sedivy

Doctor of Plant Health Program: Dissertations and Student Research

Urban agriculture provides many benefits, such as energy conservation, rainwater remediation, increased aesthetic and property value, and therapeutic use for physical, cognitive, and emotional wellbeing. Urban agriculture can also provide critical integrity to each pillar of food security: availability, access, utilization, and stability. As urban agricultural activities increase, social interactions will follow in concert. This will provide opportunities for building trust through the two-way communication of contrasting perspectives, cultures, and beliefs using impartial narratives. Growers can use knowledge and understanding gained from these positive social interactions to formulate their personal paradigms for practice and better meet the needs of each …

The North Platte River Valley: The Intersectionality Between Water Quality And People, Anni Poetzl

School of Natural Resources: Dissertations, Theses, and Student Research

The North Platte River (NPR) Valley of western Nebraska is a semi-arid watershed with row crop production, livestock production, and urban land use activity and has a population of diverse stakeholders. These land use activities contribute to the enrichment of surface waters, such as streams, which can affect human and ecosystem health, as well as economic development and recreational activities. The project objectives are to: (1) quantify the movement of dissolved inorganic nutrients from the land within the NPR Valley to the NPR via tributaries and canals, (2) identify spatiotemporal variability of nutrient limitation of periphyton growth within the NPR, …

Human And Hydrologic Influences On Nebraska's Endangered Rainwater Basin Wetlands, Sarah Thompson

Department of Earth and Atmospheric Sciences: Dissertations, Theses, and Student Research

Over half of wetlands in North America have been lost or degraded. Rainwater Basin (RWB) wetlands, located in south-central Nebraska, are a primary example of such loss; an estimated 90% have been destroyed by land conversion for agriculture. Remaining RWB wetlands are often embedded in row-crop fields, where they are threatened by altered surface water runoff flow, drainage features, and excess sediment inputs. Efforts at the state and federal level have been made to preserve this wetland complex due to the critical stopover habitat these wetlands provide for migratory birds. Land managers work to maintain sufficient water levels during migratory …

A Christmas Conversion, Maddie O’Mahoney

Marian Library Blog Archive

Student staff member explores Marian Library materials about the Christmas "conversion" of St. Thérèse de Lisieux.

Single Low-Dose Targeted Bevacizumab Infusion In Adult Patients With Steroid-Refractory Radiation Necrosis Of The Brain: A Phase Ii Open-Label Prospective Clinical Trial, Shervin R. Dashti, Robert J. Kadner, Bradley S. Folley, Jason P. Sheehan, Dong Y. Han, Richard J. Kryscio, Mary B. Carter, Lisa B. E. Shields, Brian M. Plato, Renato V. La Rocca, Aaron C. Spalding, Tom L. Yao, Justin F. Fraser

Sanders-Brown Center on Aging Faculty Publications

OBJECTIVE There is an unmet need for safe and rapidly effective therapies for refractory brain radiation necrosis (RN). The aim of this prospective single-arm phase II trial was to evaluate the safety and efficacy of a single low-dose targeted bevacizumab infusion after blood-brain barrier disruption (BBBD) in adult patients with steroid-refractory brain RN.

METHODS Ten adults with steroid-refractory, imaging-confirmed brain RN were enrolled between November 2016 and January 2018 and followed for 12 months after treatment. Bevacizumab 2.5 mg/kg was administered as a one-time targeted intra-arterial infusion immediately after BBBD. Primary outcomes included safety and > 25% decrease in lesion volume. …

Egestion Rates Of Microplastic Fibres In Fish Scaled To In Situ Concentration And Fish Density, Loren Hou, Rachel Mcneish, Timothy Hoellein

Biology: Faculty Publications and Other Works

Microplastics (particles <5 >mm) are commonly found in aquatic organisms across taxonomic groups and ecosystems. However, the egestion rate of microplastics from aquatic organisms and how egestion rates compare to other rates of microplastic movement in the environment are sparsely documented.We fed microplastic fibres to round gobies (Neogobius melanostomus), an abundant, invasive species in the Laurentian Great Lakes. We conducted two trials where round gobies were fed microplastic-containing food either a single time (1 day) or every day over 7 days.There was no difference in microplastic egestion rates from the 1 day or 7 day feeding trials, suggesting no impact of …

Exploring Risk Factors Of Alzheimer’S Disease Using Mouse Models, Xian Han

Theses and Dissertations (ETD)

Mouse models of Alzheimer’s disease (AD) that accurately recapitulate pathology and molecular changes are crucial for understanding disease mechanisms and subsequent therapeutic development. We examined five commonly used mouse models of AD (5xFAD, J20, APPNL-F, APPNL-G-F, Tau P301S) and compared their whole- and phosphoproteomes with human AD (the integration of three published datasets) to study whether they can mimic protein/RNA expression discrepancies, molecular changes, and enriched pathways found in human AD cases. The mouse models especially 5xFAD and APPNL-G-F show proteomic signatures similar to human AD but lack human-specific AD progressions, such as dysregulation of synaptic pathways and networks. Integration …

Primed And Cued: Long-Term Acoustic Telemetry Links Interannual And Seasonal Variations In Freshwater Flows To The Spawning Migrations Of Common Snook In The Florida Everglades, Jordan A. Massie, Rolando O. Santos, Ryan J. Rezek, W. Ryan James, Natasha M. Viadero, Ross E. Boucek, David A. Blewett, Alexis A. Trotter, Philip W. Stevens, Jennifer S. Rehage

Marine Science

Background: Spawning migrations are a widespread phenomenon among fishes, often occurring in response to environmental conditions prompting movement into reproductive habitats (migratory cues). However, for many species, individual fish may choose not to migrate, and research suggests that conditions preceding the spawning season (migratory primers) may influence this decision. Few studies have provided empirical descriptions of these prior conditions, partly due to a lack of long-term data allowing for robust multi-year comparisons. To investigate how primers and cues interact to shape the spawning migrations of coastal fishes, we use acoustic telemetry data from Common Snook (Centropomus undecimalis) in Everglades National …

The Dilemma Of Liberal Pluralism, Abner S. Greene

Buffalo Law Review

Supporters of reproductive rights and of queer rights may sometimes live in harmony with advocates for religious exemptions. But sometimes these goals conflict. This Article explores this tension as a matter of liberal democratic theory and U.S. constitutional law, offering a case for seeing a robust pluralism as contained within a proper understanding of the liberal democratic state. The state’s claimed authority may be the starting point, but just as the modern state was born in decentralized religious toleration, so should the modern state accommodate religious and other views of the good that compete with the state’s own views. The …

The Democratization Of Art: Placemaking Initiatives In Rural Spaces, Sarah Leigh Ayers

Theses

Creative placemaking is defined as when artists, arts organizations and community development practitioners deliberately integrate the arts and culture into revitalization work. Examining the historical context and implementation of creative placemaking practices before the coining of the term, the following essay uses Marxist and Post-Modern methodologies to examine the ways in which art can serve as a tool for driving economic growth while exploring the socio. Using examples ranging from politically driven initiative the New Deal to non-profit contemporary art museum La Chinati in Marfa, Texas, I examine the ways that culturally-driven projects have affected the rural communities in which …

Virtual Reality And Video Game Gatekeeping, Autumn Franke

Theses

This thesis focuses on the effects of the video game industry being the only influence on the development of virtual reality technology and the hindrance caused by it. The aim of this thesis is to discuss this flaw and recommend a different route to develop the technology through the education and medical fields instead of the video game industry.

The Death Of Malls: The Rise Of E-Commerce And Digitally Native Brands, Alexis Montgomery

Theses

Since the mid-2000s, malls and retail brick and mortar stores have been on the decline. Stores not making enough revenue in-person; the rise of online shopping and e-commerce, the COVID-19 pandemic, and the rise of digitally native brands have contributed to this. This research aims to figure out how the current consumer atmosphere, as well as how the rise of e-commerce and digital marketing, will impact the mall of the future. This research aims to discover how local malls are faring, if stores are truly closing and if national retail brands are pulling out of malls. This research also aims …

Targeting A Highly Repetitive Genomic Sequence For Sensitive And Specific Molecular Detection Of The Filarial Parasite Mansonella Perstans From Human Blood And Mosquitoes, Nils Pilotte, Tamara Thomas, Michael F. Zulch, Allison R. Sirois, Corrado Minetti, Lisa J. Reimer, Steven A. Williams, Lori J. Saunders

Biological Sciences: Faculty Publications

Background Mansonella perstans is among the most neglected of the neglected tropical diseases and is believed to cause more human infections than any other filarial pathogen in Africa. Based largely upon assumptions of limited infection-associated morbidity, this pathogen remains understudied, and many basic questions pertaining to its pathogenicity, distribution, prevalence, and vector-host relationships remain unanswered. However, in recent years, mounting evidence of the potential for increased Mansonella infection-associated disease has sparked a renewal in research interest. This, in turn, has produced a need for improved diagnostics, capable of providing more accurate pictures of infection prevalence, pathogen distribution, and vector-host interactions. …

What’S In An Image? A Critical Look At Study Abroad Programs Going To Africa

Journal of Comparative & International Higher Education

No abstract provided.

The Brief (Edition #22, December 2022), William & Mary Law School

The Brief

No abstract provided.

Modulation Of Monoamine Transporters By Palmitoylation In Human Health And Disease, Christopher Ryan Brown

Theses and Dissertations

The projects discussed in this dissertation outline the physiologic consequences of S-palmitoylation, a lipid-based post-translational modification, on the serotonin and norepinephrine transporters (SERT and NET, respectively). SERT and NET are trans-membrane proteins that belong to the SLC6 family of secondary active transporters. During neuro- and neuro-hormonal transmission, SERT and NET utilize the differential ionic concentrations of the extracellular and intracellular spaces to remove their corresponding substrates (serotonin [5HT] and norepinephrine [NE]) from the extracellular space. Each monoamine modulates distinct and overlapping physiologic functions, with dysregulation driving the pathogenesis of neuro-cognitive, neuro-humoral, sympathetic, cardiac, and vascular diseases. Because of this, these …

A Deep Learning-Based Framework For Food Safety, Cleanliness, And Data Privacy Assurance, Hamed Taheri Gorji

Theses and Dissertations

Food safety and foodborne diseases are significant global public health concerns. Precise, reliable, and speedy contamination detection and disinfection technology while preserving the business owners’ data privacy is an ongoing challenge for the food-service industry. Contamination in food-related services can cause foodborne illness, endangering customers and jeopardizing provider reputations.This dissertation performed a cleanliness assessment and disinfection and data privacy assurance in the food services industry using fluorescence imaging, state-of-the-art deep learning algorithms, and a novel paradigm in machine learning named federated learning. In chapter 3, we combined two deep learning algorithms (EfficientNet-B0 and U-Net) and fluorescence imaging for automatic detection …

Rapid Detection Of Recurrent Non-Muscle Invasive Bladder Cancer In Urine Using Atr-Ftir Technology, Abdullah I. El-Falouji, Dalia M. Sabri, Naira M. Lofti, Doaa M. Medany, Samar A. Mohamed, Mai Alaa-Eldin, Amr Mounir Selim, Asmaa A. El Leithy, Haitham F. Kalil, Ahmed El-Tobgy, Ahmed Mohamed

Chemistry Faculty Publications

Non-muscle Invasive Bladder Cancer (NMIBC) accounts for 80% of all bladder cancers. Although it is mostly low-grade tumors, its high recurrence rate necessitates three-times-monthly follow-ups and cystoscopy examinations to detect and prevent its progression. A rapid liquid biopsy-based assay is needed to improve detection and reduce complications from invasive cystoscopy. Here, we present a rapid spectroscopic method to detect the recurrence of NMIBC in urine. Urine samples from previously-diagnosed NMIBC patients (n = 62) were collected during their follow-up visits before cystoscopy examination. Cystoscopy results were recorded (41 cancer-free and 21 recurrence) and attenuated total refraction Fourier transform infrared (ATR-FTIR) …

Amorphous Silicon Oxynitride Coatings For Craniofacial Implants Stimulate Osteogenesis Via Nrf2 Antioxidant Activity, Neelam Ahuja

Kinesiology Dissertations - Archive

Craniomaxillofacial injuries and defects are functionally and socially debilitating. These defects require immediate attention, and most cases undergo reconstruction surgery to restore the lost tissues. Current treatment strategies such as autologous bone grafts and fixative titanium devices are well established to treat the craniofacial region. But, the limited supply of donor bone and secondary surgery limit the use of autologous bone grafts, and low bioactivity, poor osteointegration of the titanium devices, has led to an increased number of tissue engineering research for the development of newer biomaterials. Bone defects especially in the craniofacial region can have a significant portion of …

Sconce Upon A Time: Evaluating Multimodal Methods Of Researching Period Lighting Technology, A Case Study Of Drayton Hall, Neale Elizabeth Grisham

All Theses

This thesis reviews several methods of researching light sources and lighting schemes from the “long eighteenth century,”[1] on a historical site. Despite the period’s cultural reliance on lighting as well as technological advancement in this era, there has yet to be published documentation on how to engage with evidence of lighting technology on historic sites for better understanding of the site’s relationship with lighting.

Using Drayton Hall in Charleston, South Carolina as a case study, this thesis outlines and demonstrates the process of five methods of investigating period lighting technology. These methods are: wall investigation, anchorage points comparison and …

What Is Contributing To Covid-19 Mortality In Harris County, Texas?, Rachel Roy

Dissertations and Theses (Open Access)

The COVID-19 pandemic exposed long-standing inequities that have been present in the United States since its origin. While the entire country has been devastated by this pandemic, low-income and minority communities were hardest hit. Race alone does not predict poor health outcomes. Rather, the historic strategies implemented in the United States, such as redlining, placed racial and ethnic minorities in neighborhoods where cycles of disinvestment in education, transportation infrastructure, flooding infrastructure, healthy food, and clean air and water have created low socioeconomic status and poor health outcomes. This public health research aims to understand how historical processes have created and …

Pursuing Personal And Professional Passions: A Final Master's Portfolio, Eileen Tse

Master of Arts in English Plan II Graduate Projects

As an English Language Arts teacher at the secondary level with some publishing experience looking to expand my professional writing repertoire, I sought to expand and transfer my knowledge and skills in rhetoric and technical writing in different realms of interests and areas of my life. The following is my final portfolio for the Master of Arts in English, fusing my various intellectual interests and professional pursuits. My first substantive project explores the technical communication that occurs in casual online spaces by exploring the documentation and interactions in an Animal Crossing: New Horizons Facebook fan group. The project blends my …

Commonthought (2022), Commonthought Staff

Commonthought

This issue features works created by Lesley University students and covers a broad range of topics. The work itself crosses many disciplines from creative writing to visual arts.

Equine Kinesiology Tape Application To Equine Hock Joints: Impact On Lameness And Movement Evaluation, Kiara Jones

Honors College Theses

Discomfort in the hocks of horses can cause lameness, resulting in poor performance. Diagnosis by veterinarians typically includes evaluating movement or use of ultrasound or radiography to evaluate tendons, ligaments, or bones. Treatment methods and times vary depending on diagnosis, but often include joint injections, medications, and stall rest. Treatments can be costly both financially and regarding time off from practice or competition. Alternative practices such as using equine kinesiology tape to support joints may improve comfort and movement for lower cost. The objective of this project was to evaluate the ease of use and effects of equine kinesiology tape …

Seroprevalence And Titer Concentration Testing For Leptospirosis In Equine, Ashley Himmelsbaugh

Honors College Theses

The most common best management practice used to combat diseases in horses is vaccination, which can decrease the incidence or severity of illness. However, the duration of immunity will vary for each vaccination and must be considered for revaccination purposes. Titer concentration, which evaluates antibodies in the blood, may be a helpful way of determining how long an animal has immunity to a disease. Leptospirosis, a zoonotic, bacterial disease, can result in uveitis, potentially leading to blindness, and abortion in mares. One serovar, Leptospirosis pomona (L. pomona), is associated with most cases of clinical disease in horses in North America. …

Evaluating The Influence Of A Droplet Spraying/Misting System To Enhance Ammonia Volatilization From A Leachate Storage Pond: A Case Study At The Three Rivers Solid Waste Authority, Kaitlen Drafts, Suzie Boxman, Scott Ribes, Mike Terry, Bryan Staley, Joseph Flora, Nicole Berge

Faculty Publications

The Three Rivers Solid Waste Authority (TRSWA) operates a MSW landfill outside Jackson, South Carolina (USA) at which leachate ammonia concentrations are of concern. The landfill operates a droplet spraying/misting system (known as the Lilypad system) in their pond to enhance both leachate evaporation and, possibly, ammonia volatilization. The overall goals of this study were to determine the fate of nitrogen in the pond and to ultimately quantify the role the Lilypad system plays in enhancing ammonia removal. To accomplish the study goals, an empirical model based on collected leachate and mist samples, climatological data, and pond hy-draulic data was …

Combining Network Modeling And Experimental Approaches To Predict Drug Combination Responses, Deepraj Sarmah

All Dissertations

Cancer is a lethal disease and complex at multiple levels of cell biology. Despite many advances in treatments, many patients do not respond to therapy. This is owing to the complexity of cancer-genetic variability due to mutations, the multi-variate biochemical networks within which drug targets reside and existence and plasticity of multiple cell states. It is generally understood that a combination of drugs is a way to address the multi-faceted drivers of cancer and drug resistance. However, the sheer number of testable combinations and challenges in matching patients to appropriate combination treatments are major issues.

Here, we first present a …

Developmental Effects Of Chronic Low-Level Arsenic Exposure In Mouse Embryonic Stem Cells And In Human Induced Pluripotent Stem Cells, M. Chiara Perego

All Dissertations

Arsenic is an environmental contaminant commonly found in food and drinking water. Exposure to arsenic during embryonic development has been linked to reduced muscle growth, disrupted muscle development and locomotor activity, impaired neurodevelopment, reduced IQ, impaired memory and learning deficits. While the mechanisms responsible for developmental changes following in utero exposure to arsenic are not well known, one possibility is that arsenic might disrupt proper cellular differentiation. Therefore, we aimed to investigate the mechanisms by which arsenic exposure could alter stem cell differentiation into neurons.

First, we continuously exposed P19 mouse embryonic stem (ES) cells to 0.1 μM (7.5 ppb) …

Sam's Story, Anna Michelle Reid, Jennifer Vazquez

Computer Science and Software Engineering

We are exploring presenting mental health topics in video games through the eyes of an axolotl named Sam. Sam goes about his day to day life facing many difficult challenges regarding their mental health. This is an educational game to inform about different mental health symptoms and what they may look like.