Digital Commons Network^™

Phenylboronic Ester-Modified Polymeric Nanoparticles For Promoting Trp2 Peptide Antigen Delivery In Cancer Immunotherapy, Qiyan Wang, Zhipeng Dong, Fangning Lou, Yunxue Yin, Jiahao Zhang, Hanning Wen, Tao Lu, Yue Wang

Dermatology Articles

The tremendous development of peptide-based cancer vaccine has attracted incremental interest as a powerful approach in cancer management, prevention and treatment. As successful as tumor vaccine has been, major challenges associated with achieving efficient immune response against cancer are (1) drainage to and retention in lymph nodes; (2) uptake by dendritic cells (DCs); (3) activation of DCs. In order to overcome these barriers, here we construct PBE-modified TRP2 nanovaccine, which comprises TRP2 peptide tumor antigen and diblock copolymer PEG-b-PAsp grafted with phenylboronic ester (PBE). We confirmed that this TRP2 nanovaccine can be effectively trapped into lymph node, uptake by dendritic …

Here’S Your Number, Now Please Wait In Line: The Asylum Backlog, Federal Court Litigation, And Artificial Intelligence In Agency Adjudication, Youssef Mohamed

University of Chicago Law Review

Asylum seekers are individuals who flee to other countries to find sanctuary from the persecution suffered within the borders of their home countries. The U.N. High Commissioner for Refugees estimated that by mid-2021 there were nearly 4.4 million individuals actively seeking asylum worldwide, and the most recent data available surprisingly suggest that the United States granted asylum to only 31,429 persons in 2020.

The asylum system that is with us today was created when Congress enacted the Refugee Act with the goal of “respond[ing] to the urgent needs of persons subject to persecution in their homelands” and “provid[ing] a permanent …

State Policy In Federal Courts: Stabilizing The Burford Abstention Doctrine, Virginia Robinson

University of Chicago Law Review

The federal abstention doctrines govern the narrow circumstances under which a district court can decline to hear a case even though it has proper jurisdiction. One of those doctrines—Burford abstention—has generated a morass of confusion over when it applies and what goals it is meant to achieve. To find a way out of the morass, this Comment looks at contemporaneous developments in doctrines of federal court review—and at the procedural history of Burford itself—to pinpoint the precise problem that Burford abstention was created to solve. It argues that the Burford Court was wary of federal courts exercising jurisdiction in cases …

The Right To Exclude: People, Animals, And Pollution, Ariana Vaisey

University of Chicago Law Review

The Supreme Court has deemed the right to exclude one of the most fundamental property rights. Accordingly, the Court has offered the right to exclude heightened protection under the Takings Clause. However, the Court has left significant uncertainty about the scope of the right to exclude that is protected under takings doctrine. For instance, does the Takings Clause require compensation if the government, pursuant to the Comprehensive Environmental Response and Liability Act (CERCLA), requires a landowner to house another party’s pollutants?

This Comment draws from property theory and analytical jurisprudence to offer a new approach to takings analyses concerning the …

Dissolve Of Living Space: Living Space Under The Development Of Metaverse, Wenting Feng, Nuo Lyu

Architecture Thesis Prep

According to our vision, in the future, after the use of the metaverse becomes popular, we will spend a lot of time working, living and playing in the metaverse. The space needed in reality will be reduced by the use of the metaverse, and public buildings will be retained or not depending on the nature of the building. Because the focus of human life shifts from reality to the metaverse, energy and material consumption will also be reduced, and environmental problems can be properly alleviated. The nature in the real city will also be expanded by the reduction of the …

Suppression | Liberation: Memorial To The Lgbtq + Holocaust Victims, Justin Difabritis

Architecture Thesis Prep

Architecture + poetry are powerful forms of creativity, both exemplifying beauty, symbolism, emotion, and experience through structure + form. This thesis is interested in poetic architecture and its ability to not only narrate, represent, symbolize, or express, but also eternalize, the story of groups, individuals, and events.

Through the analysis of, but not limited to, memorials, tombs, and monuments, a deeper architectural understanding will be offered, one of architecture’s ability to emotionally affect others as a means of remembrance.

This research will focus on the literal + symbolic narrative and experience of the LGBTQ+ victims of the holocaust, placing a …

Panopticon: A Privacy Revelation, Kexin Wang, Zhexu Yang

Architecture Thesis Prep

Our thesis project studies and analyzes the control of Surveillance Capitalism over people’s privacy, and how to make people realize the importance of privacy through the means of an architectural/design narrative. This concept comes from Shoshana Zuboff’s The Age of Surveillance Capitalism: The Fight for a Human Future at the New Frontier of Power, which explains how tech companies collect extra data, capture people’s behavioral surplus and sell them to third party customers, such as advertising companies, thus the predictions about people’s preferences accordingly. In this process, technology companies can make tremendous profit by stealing users’ personal information and then …

The Fathers' Veto And Fatherhood As Property, Yvonne Lindgren

North Carolina Law Review

No abstract provided.

Transcriptomic Profiling Of Trypanosoma Congolense Mouthpart Parasites From Naturally Infected Flies, Sara Silva Pereira, Kawira Mathenge, Daniel Masiga, Andrew Jackson

All Peer-Reviewed Publications

Background: Animal African trypanosomiasis, or nagana, is a veterinary disease caused by African trypanosomes transmitted by tsetse flies. In Africa, Trypanosoma congolense is one of the most pathogenic and prevalent causes of nagana in livestock, resulting in high animal morbidity and mortality and extensive production losses. In the tsetse fly, parasites colonise the midgut and eventually reach the mouthparts, from where they can be transmitted as the fly feeds on vertebrate hosts such as cattle. Despite the extreme importance of mouthpart-form parasites for disease transmission, very few global expression profile studies have been conducted in these parasite forms. Methods: Here, …

Exploring The Effects Of Tree Roots On Infiltration Process, Nazife Onaral

Masters Theses

Effects of the root structures on soil infiltration dynamics are not clearly defined. Imaging the complex tree root structures and movement of water through the root ball is a challenging task to achieve without damaging the trees and roots by conventional methods. Commonly used methods are invasive, labor-intensive, and not easily accessible. Ground Penetrating Radar (GPR) has commonly been used to characterize soil profiles and it can be a reliable tool to map complex root structures with a novel high-resolution circular data collection technique. Electrical resistivity tomography (ERT) is another reliable geophysical method to image infiltration processes by the change …

Unmanned Ground Vehicle Proximal Sensing For Forage Biomass Production Estimations, Curtis Erwin

All Theses

A large increase in productivity could be realized by small increases in efficiency and utilization on grasslands due to their large area. Pre-harvest biomass estimations can help forage producers make better informed management decisions. Producers of dry hay and hay silage can better identify plant growth stages and the optimal time to harvest. Grazers can better determine the most efficient number of animals and stocking density. The goal of this study was to create a novel pre-harvest biomass estimation method utilizing compressed height combined with an unmanned ground vehicle (UGV). A compression plate named a “compression ski” was constructed and …

Venomic Characterization Of A Medically Relevant Rear-Fanged Snake, Conophis Lineatus (Dipsadidae: Xenodontinae), From Middle America, Tristan Schramer

All Theses

Most traditional research on snake venoms has focused on front-fanged snake families (Viperidae, Elapidae, and Atractaspididae). However, venom is now generally accepted as being a much more broadly possessed trait within snakes, including species traditionally considered harmless. Unfortunately, due to historical inertia and methodological challenges, the toxin repertoires of non-front-fanged snake families (e.g., Colubridae, Dipsadidae, and Natricidae) have been heavily neglected despite the knowledge of numerous species capable of inflicting medically relevant envenomations. Integrating proteomic data for validation, we perform a de novo assembly and analysis of the Duvernoy’s venom gland transcriptome of the Central American Road Guarder (Dipsadidae: Xenodontinae: …

Multiple Objective Function Optimization And Trade Space Analysis, Yifan Xu

All Theses

Optimization can assist in obtaining the best possible solution to a design problem by varying related variables under given constraints. It can be applied in many practical applications, including engineering, during the design process. The design time can be further reduced by the application of automated optimization methods. Since the required resource and desired benefit can be translated to a function of variables, optimization can be viewed as the process of finding the variable values to reach the function maxima or minima. A Multiple Objective Optimization (MOO) problem is when there is more than one desired function that needs to …

Impact Of Housing And Management On Production, Behavior, And Welfare Of Dairy Cows In Automatic Milking Systems, Lindsey Eve Davis

All Theses

The overall objective of this research was to determine the impact of Automatic Milking System (AMS) housing and management practices on cow production, behavior, and welfare of Holstein dairy cows. The first objective was to identify factors at the farm and cow level associated with lameness on AMS farms through decision tree analysis to allocate probabilities to each input. Results indicated this novel multifactorial approach of data analysis enabled us to highlight critical points that can be focused on to lessen cow-level complications or enhance farm-level housing and management practices to reduce the incidence and severity of lameness in AMS …

Cover Cropping And Organic Amendments To Improve Sandy Soils Under Organic Vegetable Production, Charles Williamson

All Theses

Coastal Plain soils in the Southeastern USA are typically sandy with poor soil structure, low soil organic carbon (SOC) content, and meager soil fertility that pose challenges to organic agriculture. Adding organic inputs is a strategy to improve these soils' physical, chemical, and biological characteristics. Here, we aim to investigate the impacts of Cover Cropping (CC) and manure inclusions on sandy soils under organic vegetable production. The experiment design was a randomized complete block with two treatments of manure application (with and without) and four CC treatments of cereal rye (Secale cereale), hairy vetch (Vicia villosa), …

Examining The Perceptions Associated With Sunday Hunting Restrictions In South Carolina, Elizabeth Piller

All Theses

Public land is an invitation for many to engage with the natural world through a variety of different activities. Sometimes these activities are mutually exclusive and can cause land use conflict, which natural resource managers must navigate. One example of this conflict is restrictions to Sunday hunting. In South Carolina, Sunday hunting is allowed on private late but banned on public Wildlife Management Area (WMA) land. This regulation remains from ‘blue laws,’ laws prohibiting certain activities on Sundays to honor the Christian Sabbath (Balestra, 2008). Blue laws are typically thought of as prohibiting alcohol, but eleven U.S. states currently have …

Patterns Of Occurrence Of The Black Basses In The Upper Savannah River Tributaries Of Georgia And South Carolina With Emphasis On Bartram’S Bass Micropterus Sp. Cf. Coosae, Caroline Cox

All Theses

Aquatic ecosystems are among the most threatened in the world due to anthropogenic alterations to the natural landscape and native biotas. Identifying the local and landscape-level environmental factors that influence the occurrence of endemic species can help protect aquatic ecosystems by facilitating predictions of where hybridization or replacement with generalist species may occur across the landscape. The need for such predictions is pronounced for black bass species in the southeastern United States. Bartram’s Bass (Micropterus sp. cf. coosae) is a provisional species of conservation concern. Allelic frequencies of Bartram’s Bass in Savannah River reservoirs and tributaries have been …

To Be A Cloud, Huan Laplante

All Theses

The intersections between Buddhism, queerness, and art making support one another in their power to unveil the impermanent nature of the self. My work rests at these moments, taking refuge in the ability to simultaneously release and rebuild a sense of self that exists beyond the boundaries of individualism. To Be a Cloud documents my journey of looking into the origins of the self and reflecting upon the transience of body and mind. Utilizing a broad range of sensuous materials such as textiles, handmade paper, and charcoal, paired with the repetitive motions of stitching, tearing, and mark-making cultivate a rhythmic …

Appearance-Preserved Portrait-To-Anime Translation Via Proxy-Guided Domain Adaptation, Wenpeng Xiao, Cheng Xu, Jiajie Mai, Xuemiao Xu, Yue Li, Chengze Li, Xueting Liu, Shengfeng He

Research Collection School Of Computing and Information Systems

Converting a human portrait to anime style is a desirable but challenging problem. Existing methods fail to resolve this problem due to the large inherent gap between two domains that cannot be overcome by a simple direct mapping. For this reason, these methods struggle to preserve the appearance features in the original photo. In this paper, we discover an intermediate domain, the coser portrait (portraits of humans costuming as anime characters), that helps bridge this gap. It alleviates the learning ambiguity and loosens the mapping difficulty in a progressive manner. Specifically, we start from learning the mapping between coser and …

Rapamycin Inhibits Light-Induced Necrosome Activation Occurring In Wild-Type, But Not Rpe65-Null, Mouse Retina, Chunfeng Lu, Songhua Li, Minghao Jin

School of Medicine Faculty Publications

PURPOSE. Both photodamage and aberrant visual cycle contribute to disease progress of many retinal degenerative disorders, whereas the signaling pathways causing photoreceptor death remain unclear. Here we investigated the effects of intense photo-stress on (1) necrosome activation in wild-type and RPE65-null mice, (2) interaction of p62/Sequestosome-1 with the necrosome proteins, and (3) the effects of rapamycin on photodamage-induced necrosome activation and retinal degeneration in wild-type mice. METHODS. Dark-adapted rd12 mice and 129S2/Sv mice with or without rapamycin treatment were exposed to 15,000 lux light for different times. Expression levels and subcellular localization of proteins were determined through immunoblot and immunohistochemical …

Multidisciplinary Simulation Of Trauma In Pregnancy With Resuscitative Endovascular Balloon Occlusion Of The Aorta (Reboa) Utilization., Peter Hopmann, Jaya Sai Varre, Gary Duncan, William B Devoe, Brad D Gable

Trauma and Acute Care Articles

Background Studies have demonstrated the use of resuscitative endovascular balloon occlusion catheters of the aorta (REBOA) in the setting of postpartum hemorrhage and traumatic hemorrhagic shock. However, REBOA is infrequently utilized leading to a lack of clinician comfort. This study's aim was to demonstrate the utility of REBOA in a hemorrhaging pregnant trauma patient and improve clinician comfort with the placement of REBOA while emphasizing collaboration between medical specialties. Methods A multidisciplinary in-situ simulation was developed for the management of a pregnant patient with an abdominal gunshot wound evaluated by obstetrics and surgery teams. A trauma survey, emergency c-section, massive …

Ecological Calendars, Food Sovereignty, And Climate Adaptation In Standing Rock, Morgan L. Ruelle, Aubrey Joshua Skye, Evan Collins, Karim-Aly S. Kassam

Sustainability and Social Justice

Indigenous food sovereignty relies on ecological knowledge of plants and animals, including knowledge related to their development and behavior through the seasons. In the context of anthropogenic climate change, ecological calendars based on Indigenous knowledge may enable communities to anticipate seasonal phenomena. We conducted research with communities in the Standing Rock Nation (North and South Dakota, USA) to develop ecological calendars based on their ecological knowledge. We present ecological calendars developed in seven communities through a series of workshops and interviews. These calendars are rich with knowledge about temporal relations within each community's ecosystem, including the use of plants and …

Equity In The Classroom For Individuals With Disabilities At Grand Valley State University, Abagail Boyd

Honors Projects

The purpose of this project is to identify areas of equity and inequity for students with disabilities at Grand Valley State University (GVSU) pertaining to their ability to successfully complete their degrees. GVSU has a history of being at the forefront of accommodations with their creation of the LINKS program for students with autism spectrum disorders and their policies on assistance and service animals in the classroom. However, it is not known whether the accommodations and policies currently in place offer the students with disabilities an equitable opportunity for academic success as GVSU students without disabilities. To obtain this information, …

Mental Health Concerns In The Pediatric Population Following Covid-19, Kristina N. Yaczik, Ashley M. Komosinski

Honors Projects

The COVID-19 pandemic has contributed to an increase in stress and mental health concerns in the pediatric population. Research indicates a decrease in pediatric mental health incidences in 2020, followed by an increase in 2021 and 2022. It is thought that the initial decrease may be due to the intensity of the pandemic at the time and a lack of hospital beds available. The increase suggests a response to the high levels of adversity and stress children and adolescents faced both during and after the origination of the pandemic. The evidence supports the idea that the COVID-19 pandemic had a …

Xenotransplantation: Using Animals To Save Human Lives, Casey Restau

Honors Projects

The United States currently faces an extreme shortage of organs available for those in need of life-saving transplants. Xenotransplantation, using tissues or organs from non-human animal sources, could provide a solution to this daunting problem. The science behind xenotransplantation has been studied for several decades, however, there is yet to be a truly successful case of xenotransplantation. Major breakthroughs in this experimental treatment have been made within the past couple of years, but progress is slow. Many ethical and moral issues surrounding xenotransplantation have attributed to its controversial nature that could prevent the treatment from becoming reality.

A Review Of The Benefits, Risks, And Guide To Adopting Barefoot Running, Joe Wallace

Honors Projects

This presentation discusses the history of barefoot running including empirical evidence of the effects on injury prevalence, rehabilitation, and performance enhancement in runners. Prehistoric humans made use of their endurance running skills to run down their prey for food, so humans are built to be endurance runners. Modern human runners experience high injury rates even after a lot of research has been put into designing the most effective running shoes for injury prevention. Careful selection of scholarly research articles was performed to develop a guide for runners or practitioners interested in the adoption of barefoot running. The research found that …

Opening Pandora’S Box: Charles D’Orléans’S Reception And The Work Of Critical Bibliography: The 2022 Annual Meeting Keynote, Elizaveta Strakhov

English Faculty Research and Publications

No abstract provided.

A Comparative Study Of Instructional Perspectives Among Learning And Development Practitioners, Merzudin Selimovic

Dissertations

The instructional perspectives of learning and development practitioners have a critical impact on their learners. This study aimed to determine if a relationship existed between years of experience of a learning and development practitioner and how they score on the seven factors of Henschke’s (1989) Modified Instructional Perspectives Inventory (MIPI). The MIPI consisted of seven factors: 1) Teacher Empathy with Learners, 2) Teacher Trust of Learners, 3) Planning and Delivery of Instruction, 4) Accommodating Learner Uniqueness, 5) Teacher Insensitivity Toward Learners, 6) Learner-centered Learning Process (Experience-based Learning Techniques), and 7) Teacher-centered Learning Process. The MIPI is a revised version of …

The Role Of Virtual Reality In Art Therapy To Mitigate Autism Spectrum Disorder (Asd) Symptoms, James Hutson

Faculty Scholarship

Traditional art therapy sessions are designed for face-to-face engagement with patients as with other mental health services such as counseling. However, the pandemic of 2019 severely limited access to these services and, initially, led to widespread cancelation and postponement until the nature of COVID-19 could be better understood. When treatment resumed, video conferencing was the preferred method of holding therapy sessions one-on-one to diagnose patients and provide services. Similar approaches were taken in art therapy with less efficacy given the hands-on nature of the required activities. With the rise of virtual reality (VR) as a more widely accessible technology since …

Landlord Liability For Tenant-On-Tenant Harassment Under The Fair Housing Act, Mary Karapogosian

Cardozo Law Review

No abstract provided.