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2021

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Beautiful Hunt, Dena Leonard Pruett Jan 2021

Beautiful Hunt, Dena Leonard Pruett

All ETDs from UAB

Beautiful Hunt explores the moment when you realize what is now never will be again no matter how hard you might try to go back. This work also explores developing selfhood – the tension between who we are, who we want to become, how we see ourselves, and how others see us. How is our story told, and who gets to tell it? In January 1998, Alice Landry arrives in the small town of Sans Souci, the boot of the boot of Louisiana. Her father, Sans Souci born and raised, moved away when he married Alice’s mom, a New York …

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Mechanism Of Stat3 Mediated Drug Persistence In Chronic Myeloid Leukemia Stem Cells, Sweta B. Patel Jan 2021

Mechanism Of Stat3 Mediated Drug Persistence In Chronic Myeloid Leukemia Stem Cells, Sweta B. Patel

All ETDs from UAB

Drug persistence is one of the major impediments for cancer therapeutics. There are two known evolutionary models for tumor drug persistence. First, a pre-existing sub-population is inherently resistant to treatment; and second, a sub-population acquires resistance by drug-induced molecular reprograming. One ideal model to study the mechanism of drug persistence is chronic myeloid leukemia (CML), a hematopoietic stem cell (HSC) disorder. HSCs acquire a single translocation between chromosome 9 and 22, forming BCR-ABL, a constitutively active tyrosine kinase. Tyrosine kinase inhibitors (TKI), the standard regimen, have been able to efficaciously control CML and yet many patients relapse upon treatment discontinuation …

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Evaluation Of Antimicrobial Effect Of Licorice Extrcat Agiasnt Oral Microorganisms, Roshanak Rastegar Jan 2021

Evaluation Of Antimicrobial Effect Of Licorice Extrcat Agiasnt Oral Microorganisms, Roshanak Rastegar

All ETDs from UAB

Introduction: The causative factors of dental caries have been studied for many years, however, preventing the formation of dental caries remains an elusive task. Microorganisms have been the focal point of numerous studies as a prime cariogenic factor. Streptococcus mutans and Candida albicans have been frequently co-isolated from dental biofilm in patients with early childhood caries (ECC) and studies have demonstrated the synergistic effects of these two microorganisms in promoting tooth demineralization. Acid and glucan production, which are two virulence factors produced by S. mutans that mediate biofilm formation and tooth decay, have been shown to be promoted during co-colonization …

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Efficacy Of Lower Incisor Intrusion Using Clear Aligners, Cason Roberson Jan 2021

Efficacy Of Lower Incisor Intrusion Using Clear Aligners, Cason Roberson

All ETDs from UAB

Objective: The primary objective of this study is to evaluate pre and posttreatment lateral cephalometric radiographs on patients treated with Invisalign by the same orthodontist where lower incisor intrusion was prescribed and to determine the amount of true lower incisor intrusion achieved during treatment. Methods: This retrospective case series study included 48 patients with an overbite exceeding 2mm, who were treated with Invisalign clear aligner therapy, and whose Clincheck treatment plan included lower incisor intrusion. The mean age of the study group was 27 years with 14 (29%) of the subjects being male and 35 (71%) being female. The mean …

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A Grounded Theory Study: The Lived Experiences Of K-12 Administrators Regarding Leadership Effectiveness Over Time, Sandy Georgette Deades Ritchey Jan 2021

A Grounded Theory Study: The Lived Experiences Of K-12 Administrators Regarding Leadership Effectiveness Over Time, Sandy Georgette Deades Ritchey

All ETDs from UAB

The purpose of this study was to generate a theory in education comparable to studies in other disciplines by exploring how current leadership theories can be expanded to explain how leadership effectiveness changes over time. This study explored active and retired principals' experiences to see how their effectiveness may or may not have changed over time. I was particularly interested in learning if there was a point in their careers when they perceived that they were no longer as effective as they used to be or could have been, what this looked like, and how this guided their next steps. …

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Biomarker And Target Discovery In Cancer, Alyncia Dominique Robinson Jan 2021

Biomarker And Target Discovery In Cancer, Alyncia Dominique Robinson

All ETDs from UAB

Cancer is a complex disease characterized by uncontrolled growth of transformed cells that can arise in many tissue types throughout the body (e.g., breast, lung, prostate, pancreas, lymph nodes) and is a major cause of death worldwide. Cancer progression resulting in aggressive or metastatic disease accounts for one of the leading causes of death worldwide, second only to heart disease in the US. Incidentally, cancer-related mortality has been on a steady decline, dropping 25% over the last 25 years [1]. This could be attributed to improved and earlier diagnoses and better treatment options being developed over the past few decades. …

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Keller-Segel Type Chemotaxis Model: Asymptotic Behavior Of The Small Data Solution, Jean D. Rugamba Jan 2021

Keller-Segel Type Chemotaxis Model: Asymptotic Behavior Of The Small Data Solution, Jean D. Rugamba

All ETDs from UAB

This dissertation’s work is on asymptotic behavior of a Keller- Segel type chemotaxismodel with logarithmic sensitivity and logistic growth. The logarithmic singularity in the system is removed via the inverse Hopf-Cole transformation. Then, for the transformed system, we study the Green’s function of the corresponding linear system, linearized around a constant equilibrium solution, and the results give us a detailed point-wise description of the Greens function, which, itself, is significant in linear theory. Next, with the results on the Green’s function, we study small data solution to the nonlinear system by making use of Duhamel’s principle. This provides a descriptive …

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Urban School Leaders’ Perceptions Of Community Education Within Essentialist Educational Policy Contexts, Ashley Samuels Jan 2021

Urban School Leaders’ Perceptions Of Community Education Within Essentialist Educational Policy Contexts, Ashley Samuels

All ETDs from UAB

Urban schools face the enormous task of providing a wide range of support to students. These supports include academics, socio-emotional learning, health, nourishment, and even clothing. Students arrive with challenges that make it difficult to concentrate on their academic studies. The community education model can supply students in urban schools with needed resources so that they may prioritize their academics. A community education model is a holistic approach to providing support to students. With this in mind, the urban school leader must find a way to provide comprehensive support to students, both through community education and in consideration of essentialist …

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Tensor Completion And Total Variation Denoising And Deblurring In Tensor Spaces, Fatoumata Sanogo Jan 2021

Tensor Completion And Total Variation Denoising And Deblurring In Tensor Spaces, Fatoumata Sanogo

All ETDs from UAB

Tensor completion is a higher-order generalization of matrix completion where the goal is to recover a low-rank tensor from a partially observed tensor. Here we work on a numerical method to reconstructs a tensor (matrix) with missing entries by finding the optimal factors through linear least squares and the singular vector through a proximal algorithm of soft thresholding. The performance of our algorithm is tested on color images and surveillance videos.In addition, we continued working on those algorithm to get an optimal way of finding the regularization parameter to improve the quality of our output. For this purpose we used …

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Cns Antigen Presentation And Immune Cell Infiltration In An Α-Syn Model Of Parkinson Disease, Aubrey Michelle Schonhoff Jan 2021

Cns Antigen Presentation And Immune Cell Infiltration In An Α-Syn Model Of Parkinson Disease, Aubrey Michelle Schonhoff

All ETDs from UAB

Parkinson disease (PD) is a neurodegenerative movement disorder that is characterized by aggregated alpha-synuclein (a-syn), loss of dopaminergic neurons, and neuroinflammation. This neuroinflammation includes the activation of immune cells that reside in the CNS, such as microglia and border associated macrophages (BAMs), in addition to the infiltration of peripheral leukocytes and increased cytokine and chemokine production. Because of the involvement of both the innate and adaptive immune systems, we sought to investigate their interaction through antigen presentation and determine what role this played in disease progression. Using an a-syn based mouse model of PD, our studies have provided evidence via …

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Embodied Fat Stigma And Health Beliefs About Exercise And Diet, Brie Scrivner Jan 2021

Embodied Fat Stigma And Health Beliefs About Exercise And Diet, Brie Scrivner

All ETDs from UAB

The purpose of this dissertation is to examine how individuals navigate the cultural mandate for thinness, which pressured individuals to pursue weight loss through exercise and restrictive diets. While sustainable weight loss is not probable for the majority of people, there are still significant physical and mental health benefits to be had from engaging in regular, enjoyable movement. For many, physical activity is an important component of a healthy lifestyle. It can improve quality of life for individuals regardless of weight, body size, chronic illness, or disability. However, many fitness facilities focus on weight loss as the most essential goal …

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The Cellular Role Of Tyrosyl-Dna Phosphodiesterase 1 N-Terminal Domain In Topoisomerase 2-Dna Covalent Complex Repair In Yeast, Isaac Andres Segura Jan 2021

The Cellular Role Of Tyrosyl-Dna Phosphodiesterase 1 N-Terminal Domain In Topoisomerase 2-Dna Covalent Complex Repair In Yeast, Isaac Andres Segura

All ETDs from UAB

Tyrosyl-DNA phosphodiesterase 1 (Tdp1) removes adducts from DNA-ends, including damaged nucleotides and protein-DNA crosslinks such as DNA topoisomerases (Topo1 and Topo2) and Tdp1 itself. The N-terminal domain (NTD) of Tdp1 has been understudied, structurally unresolved, and seemingly dispensable for in vitro catalytic activity. However, our lab made the novel observation that the NTD is critical for Tdp1 cellular activity in removing Topo1-DNA covalent complexes (Topo1cc). Removal of the first 80 residues (yeast Tdp1 NTD) results in the loss of the toxic phenotype induced by full-length Tdp1 catalytic mutants. This suggests that in cells the NTD has a critical function in …

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Assesing The Degree Of Intereron Gamma Induced Stat1 Activation On Peripheral Lymphocytes In Patietns With Rheumatoid Arthritis, Vishal Sharma Jan 2021

Assesing The Degree Of Intereron Gamma Induced Stat1 Activation On Peripheral Lymphocytes In Patietns With Rheumatoid Arthritis, Vishal Sharma

All ETDs from UAB

Rheumatoid Arthritis (RA) is a systemic autoimmune disease with debilitating side effects, from joint swelling to bone erosion and bone deformation. Geographically, RA affect 0.5 – 1% of the worldwide populations, affecting women more than men. Studies have shown that CD4 T cells infiltrate RA synovium and are key to the pathogenesis of RA. Furthermore, drugs targeting co-stimulatory T cell molecules such as abatacept can be beneficial in controlling RA disease activity.Interferon gamma (IFN) is a pleotropic cytokine that contributes to inflammation by aiding in CD4 T cell differentiation into Th1 subtype, enhancing MHC class II presentation, supplementing lymphocyte trafficking, …

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Risk Of Delirium With Opioid Use Among Older Adults In The Emergency Department, Rachel Michelle Skains Jan 2021

Risk Of Delirium With Opioid Use Among Older Adults In The Emergency Department, Rachel Michelle Skains

All ETDs from UAB

Objectives: Delirium affects 7-17% of older Emergency Department (ED) patients. Inadequate pain control and opioid pain management have been reported to increase risk for delirium. The aim of this study was to evaluate the association between pain severity, opioid exposure, and delirium among older ED patients.Methods: A single-center retrospective cohort study was conducted in an academic Geriatric ED. Patients aged ≥65 years with an Identification of Seniors at Risk (ISAR) score ≥2 and an Emergency Severity Index (ESI) level 3 were enrolled into the Geriatric ED Pathway. Those who received a delirium screening using the Nursing Delirium Screening Scale (NuDESC) …

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Examining Approaches For Peacebuilding In Post-Conflict, Post-Good Northern Ireland, Evan Wiley Smith Jan 2021

Examining Approaches For Peacebuilding In Post-Conflict, Post-Good Northern Ireland, Evan Wiley Smith

All ETDs from UAB

In this paper, I broadly describe the timeline of the conflict in Northern Ireland, examine negative and positive peace approaches to peacebuilding including political (or consociationalism-based), human rights-based, and reconciliation-based methods, and present my own conclusions based on the literature review I conducted as to the most efficacious strategy for ensuring long-lasting peace in Northern Ireland. To do this, I reviewed numerous articles, papers, and chapters on the conflict in Northern Ireland, approaches in post-conflict reconciliation, and conflict resolution theory. Because the conflict in Northern Ireland ended approximately twenty years ago, much of the research referenced in this paper is …

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Added Sugar Consumption And Prediabetes In U.S. Adults: A Cross-Sectional Analysis Of The National Health And Nutrition Examination Survey, 2013-2018, Nadia Markie Sneed Jan 2021

Added Sugar Consumption And Prediabetes In U.S. Adults: A Cross-Sectional Analysis Of The National Health And Nutrition Examination Survey, 2013-2018, Nadia Markie Sneed

All ETDs from UAB

Prediabetes is a modifiable risk factor for type 2 diabetes (T2D) that effects 88- million U.S. adults. Added sugar is linked to the risk for prediabetes through direct and indirect mechanisms that promote hepatic and whole-body insulin resistance. Added sugar is overconsumed and totals ~13% of American’s daily caloric intake, with consumption highest for non-Hispanic Blacks and Hispanic minority populations also disproportionality affected by prediabetes and T2D. The effects of total added sugar on prediabetes have been mixed; however, total added sugar intake has primarily been examined using added sugar proxies (e.g., sugar-sweetened beverages, fructose), likely increasing systemic measurement error …

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Association Of Abdominal Obesity And Risk Of Atrial Fibrillation: Findings From The Reasons For Geographic And Racial Differences In Stroke (Regards) Study, Joonseok Kim Jan 2021

Association Of Abdominal Obesity And Risk Of Atrial Fibrillation: Findings From The Reasons For Geographic And Racial Differences In Stroke (Regards) Study, Joonseok Kim

All ETDs from UAB

Background: Our knowledge of the association between abdominal obesity (AO) and the risk of atrial fibrillation (AF) after adjusting for body mass index (BMI) is limited. Methods: We included 11,617 black and white participants (mean age 63.0 + 8.4 years) from the REGARDS (REasons for Geographic and Racial Differences in Stroke) national cohort study who were free of AF at baseline between 2003 and 2007, and completed a follow-up exam between 2013 and 2016 with assessment of AF. A multivariable logistic regression model was used to estimate the odds ratio (OR) with 95% confidence interval of incident AF associated with …

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The Kinetic Effects Of Nanoconfinement, Aggregate Phase Type, And Pressure On Some Thermally Stimulated Processes, Victoria Lynn Stanford Jan 2021

The Kinetic Effects Of Nanoconfinement, Aggregate Phase Type, And Pressure On Some Thermally Stimulated Processes, Victoria Lynn Stanford

All ETDs from UAB

This research explores the effects of nanoconfinement, aggregate state type, and an inert gas pressure on the kinetics of thermally stimulated processes. The processes considered are solution crystallization and thermal decomposition. The kinetic effects are measured via differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), and high pressure differential scanning calorimetry (HPDSC), combined with isoconversional kinetic analysis. The first chapter demonstrates that DSC can be applied to measure the kinetics of nonisothermal crystallization. The crystallization of potassium nitrate and ammonium perchlorate are from unsaturated and saturated aqueous solutions. An advanced isoconversional method demonstrates that the process is represented by negative values …

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Influence Of Race, Gender, Rurality, And Dyadic Health On Symptom Pattern Trajectories In Persons With Advanced Heart Failure, Macy Lynn Stockdill Jan 2021

Influence Of Race, Gender, Rurality, And Dyadic Health On Symptom Pattern Trajectories In Persons With Advanced Heart Failure, Macy Lynn Stockdill

All ETDs from UAB

Individuals living with heart failure experience a high symptom burden that must be addressed to improve their quality of life as well as the quality of life of their family caregivers. This is a challenging task as different situational and individual factors, including clinical/physiological factors and cultural factors, can affect an individual’s symptom experience. The purpose of this dissertation study was to examine existing symptom pattern trajectories and associated factors (sociodemographic, clinical/physiological characteristics, dyadic health) among a sample of under-resourced and racially diverse older adults with advanced heart failure living in the Deep South. This purpose was accomplished through four …

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An Investigation Into The Effects Of Diet On Pain And Pain Disparities, Larissa Jane Strath Jan 2021

An Investigation Into The Effects Of Diet On Pain And Pain Disparities, Larissa Jane Strath

All ETDs from UAB

Chronic pain is one of the most common and disabling disorders in Westernsociety. Recently, it has been suggested that dietary quality may play a key role in the development and maintenance of pain. Additionally, diet differs between demographic groups, as does physiological differences in response to metabolites. We sought to explore 1) the central way in which diet influences pain sensitivity and 2) if dietary patterns affected various demographic groups differently. We first employed a rat model to observe diet-related changes in the dorsal horn of the spinal cord. In the absence and presence of an injury, rats fed a …

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Characterization Of Color Centers In Diamond For Laser Applications, Shova Devi Subedi Jan 2021

Characterization Of Color Centers In Diamond For Laser Applications, Shova Devi Subedi

All ETDs from UAB

Diamond has been gaining a lot of interest in the field of photonics such as quantum optics, nano-photonics, quantum computation, magnetometry, sensing, laser development, and color center physics as it provides a remarkable platform to combine its non-linear optical properties in conjunction with the unique optical and spin properties of its color centers. Besides that, energetic pulsed lasers operating in the visible to near IR spectral range are mostly obtained from non-linear frequency conversion which is less efficient, expensive, and requires nonlinear crystal with excellent optical quality, a special cut to meet the perfect phase-matching condition. Another alternative is dye …

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Attitudes, Beliefs, And Perceived Self-Efficacy Pre- And Post- Suicide Prevention Training, Angela Marie Sullivan Jan 2021

Attitudes, Beliefs, And Perceived Self-Efficacy Pre- And Post- Suicide Prevention Training, Angela Marie Sullivan

All ETDs from UAB

A 2017 World Health Organization (WHO) data brief included suicide in the top 20 causes of death worldwide. The WHO also listed suicide as the second leading cause of death for those aged 15 – 29 worldwide. In the US, suicide is the leading cause of violent death and has been consistently ranked as the 10th leading cause of death among all age groups in the US since 2008. In Alabama, the CDC reports suicide as the 11th leading cause of death in the state and the second leading cause of death for those aged 15 – 34. This study …

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Developing A Core Set Of Nursing-Sensitive Indicators For International Pediatric Oncology Nursing Practice, Courtney Erin Sullivan Jan 2021

Developing A Core Set Of Nursing-Sensitive Indicators For International Pediatric Oncology Nursing Practice, Courtney Erin Sullivan

All ETDs from UAB

Although nursing sensitive indicators (NSIs) have been developed to measure factors influencing nursing care quality and patient outcomes in general and in select specialty areas, a core set of NSIs for international pediatric oncology nursing practice does not exist. Quality nursing care delivery in pediatric oncology is essential to achieving optimal patient outcomes and closing the 50% survival gap between high-income and low- and middle-income countries. To enhance global childhood cancer outcomes influenced by nursing, this dissertation research was conducted with the purpose of developing a preliminary core set of NSIs for international pediatric oncology nursing that is important, actionable, …

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The Impact Of Storm Surge, High Intensity Rainfall And Sea Level Rise On Coastal Cities, Qing Sun Jan 2021

The Impact Of Storm Surge, High Intensity Rainfall And Sea Level Rise On Coastal Cities, Qing Sun

All ETDs from UAB

Storm surge, high-intensity rainfall, and sea level rise have seriously threatened the critical infrastructure of these coastal cities and the lives and properties of urban residents. Understanding the impact of a single extreme event and a cascade of extreme events on coastal cities can help people better understand the expected damage, thereby providing a theoretical basis for delineating the path of mitigation and recovery plans. Therefore, this thesis takes the two coastal cities of New York City (NYC) and the City of Mobile as case studies. Two different research methods are used to evaluate the impact of storm surge, high-intensity …

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An Evaluation Of The Impact Of Medical Home Structures And Care Processes On Temporary Profile Days Among Active-Duty U.S. Army Soldiers, Tanekkia M. Taylor-Clark Jan 2021

An Evaluation Of The Impact Of Medical Home Structures And Care Processes On Temporary Profile Days Among Active-Duty U.S. Army Soldiers, Tanekkia M. Taylor-Clark

All ETDs from UAB

Readiness, the Armed Forces’ ability to carry out a range of military operations, is one of the U.S. Army’s highest strategic priorities. The medical readiness of soldiers is a critical component of overall operational readiness. The greatest threat to medical readiness is acute musculoskeletal injuries (MSIs). Medical providers place soldiers on medical limitations referred to as a “temporary profile” to facilitate treatment and recovery of acute MSIs. Poorly managed temporary profiles negatively impact soldiers’ work attendance and performance, leading to the loss or limitation of over 25 million training/duty days annually. Changes within the primary care setting, including implementing the …

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Examining The Trends Of Craft Beer Legislation In The U.S., Erica Techo Jan 2021

Examining The Trends Of Craft Beer Legislation In The U.S., Erica Techo

All ETDs from UAB

Brewing and beer production historically have been intertwined with government, politics, and regulation in the United States. With the growth of the craft beer industry, discussions surrounding brewing regulation have refocused on their impact on smaller businesses and this growing segment of the alcohol beverage market. The history of beer and craft beer in the United States has been studied, as well as the impact of taxation and regulation on business, but research on craft brewing regulation has been relegated to broad studies of specific regulation or case studies of cities and states covering several regulations. This present research seeks …

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Waffle, Ashley Tippit Jan 2021

Waffle, Ashley Tippit

All ETDs from UAB

Waffle is a novel about a high school senior realizing she has an anxiety disorder and is pansexual. Aside from wanting to tell a version of my own story, I want this to be a young adult novel that has appropriate, diverse representation. Given that several characters have identities different than mine (Jay having a single parent, Ginger being Black and having Type One Diabetes, Ella being transgender with divorced parents, and Birdie being Taiwanese-Korean American), I will need a lot of research and help to write these characters well. I want the information and experiences regarding race, gender, sexuality, …

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Inside The Bellotti Court, William E. Lee Jan 2021

Inside The Bellotti Court, William E. Lee

Cardozo Arts & Entertainment Law Journal

The article examines the legal and historical connections between the Supreme Court's decisions in Bellotti v. Federal Communications Commission and Citizens United v. Federal Election Commission, emphasizing how Bellotti laid the groundwork for Citizens United. It argues that Justice Powell's opinion in Bellotti was pivotal in establishing that corporations have First Amendment rights to engage in political speech, a principle later expanded in Citizens United. The article critiques the narrative that Powell solely favored corporate interests, highlighting his broader concerns about government overreach in regulating speech. It also explores the implications of these rulings on campaign finance …

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An Estate Plan For Kanye West, Thomas E. Simmons Jan 2021

An Estate Plan For Kanye West, Thomas E. Simmons

Cardozo Arts & Entertainment Law Journal

One inventory item in megastar Kanye West's vast portfolio of assets merits a unique sort of care and safeguarding his right ofpublicity. The right ofpublicity is a property interest which represents the commercial value of a celebrity's name, image, and likeness. In some states, including California, the right survives the celebrity's death and is freely alienable and devisable. A protective arrangement, such as a trust, is often pursued to impose postmortem use and transferability restrictions on property that has particular importance to the testator. This Article proposes a noncharitable purpose trust as a means by which Kanye West's right of …

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Table Of Contents - Cardozo Arts & Entertainment Law Journal, Vol. 39, Iss. 2 Jan 2021

Table Of Contents - Cardozo Arts & Entertainment Law Journal, Vol. 39, Iss. 2

Cardozo Arts & Entertainment Law Journal

No abstract provided.

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