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Articles 11281 - 11310 of 196793
Full-Text Articles in Entire DC Network
Test Transferability Of 3d-Mot Training On Soccer Specific Parameters, Micaela Dusseault
Test Transferability Of 3d-Mot Training On Soccer Specific Parameters, Micaela Dusseault
Honors Theses
Objective: The benefits of perceptual-cognitive training in elite level athletes has recently been investigated in multiple sports such as basketball, soccer, and archery, but conclusive evidence proving test transferability of 3D-MOT training is lacking. The purpose of this research is to examine the transferability of perceptual-cognitive training to on-field soccer performance parameters. Participants: NCAA Division I women’s soccer players (n=22) between the ages of 18-25 who were placed into either the experimental group (n=10) or control group (n=12). After baseline testing for both groups to determine visual tracking speed (VTS), the experimental group completed 10 3D-MOT training sessions with NeuroTracker …
An Outbreak Of Canine Schistosomiasis In Utah Acquisition Of A New Snail Host (Galba Humilis) By Heterobilharzia Americana, A Pathogenic Parasite On The Move, Eric S. Loker, Scott Z. Dolginow, Suzanne Pape, Colin D. Topper, Randall J. Dejong
An Outbreak Of Canine Schistosomiasis In Utah Acquisition Of A New Snail Host (Galba Humilis) By Heterobilharzia Americana, A Pathogenic Parasite On The Move, Eric S. Loker, Scott Z. Dolginow, Suzanne Pape, Colin D. Topper, Randall J. Dejong
University Faculty Publications and Creative Works
Parasites with complex life cycles engaging multiple host species living among different environments well-exemplify the value of a cross-cutting One Health approach to understanding fundamental concerns like disease emergence or spread. Here we provide new information regarding a pathogenic schistosome trematode parasite of both wild and domestic mammals that has recently expanded its known range from mesic/wet environments of the southeastern United States to the arid southwest. In 2018, 12 dogs living near a man-made pond in Moab, Utah, were found positive for Heterobilharzia americana, the most westerly report of this endemic North American schistosome, and the first from Utah. …
Comparison Of Sample Types From White-Tailed Deer (Odocoileus Virginianus) For Dna Extraction And Analyses, Jessie Edson, Justin Brown, William L. Miller, David Walter
Comparison Of Sample Types From White-Tailed Deer (Odocoileus Virginianus) For Dna Extraction And Analyses, Jessie Edson, Justin Brown, William L. Miller, David Walter
University Faculty Publications and Creative Works
Collection of biological samples for DNA is necessary in a variety of disciplines including disease epidemiology, landscape genetics, and forensics. Quantity and quality of DNA varies depending on the method of collection or media available for collection (e.g., blood, tissue, fecal). Blood is the most common sample collected in vials or on Whatman Flinders Technology Associates (FTA) cards with short- and long-term storage providing adequate DNA for study objectives. The focus of this study was to determine if biological samples stored on Whatman FTA Elute cards were a reasonable alternative to traditional DNA sample collection, storage, and extraction. Tissue, nasal …
Labor's New Localism, Andrew Elmore
Labor's New Localism, Andrew Elmore
Faculty Scholarship
Millions of workers in the United States, disproportionately women, immigrants, and people of color, perform low-paid, precarious work. Few of these workers can improve their workplace standards because the National Labor Relations Act ("NLRA") does not sufficiently protect their right to form unions and collectively bargain. Lacking sufficient influence in federal and state government to strengthen labor and employment law, unions and worker centers have increasingly sought to build power in cities. The shift to local labor lawmaking has delivered local minimum wage, paid sick leave, and fair scheduling ordinances covering millions of low-wage workers, as well as groundbreaking unionization …
Organizational Culture: An Examination Of The Role Of Leadership In Neutralizing The Negative Effects Of Technostress During Operational Shifts, David P. Kirkland
Organizational Culture: An Examination Of The Role Of Leadership In Neutralizing The Negative Effects Of Technostress During Operational Shifts, David P. Kirkland
All-Inclusive List of Electronic Theses and Dissertations
COVID-19 created a support problem for public universities across the United States and required that IT departments and professionals alter how they performed in 2020, and perhaps beyond. IT professionals tasked with safeguarding large amounts of data were required to shift to a teleworking posture to continue offering a similar level of service as previously expected. In addition to the technological shift that organizations experienced because of COVID-19, leadership challenges also impacted IT departments across the United States. The rapid shift of operational duties has the propensity to increase technology-related stress, due to employee perception of being successful in their …
Clinical Applications Of Magnetic Resonance Imaging Based Functional And Structural Connectivity, Chengyuan Wu, Francisca Ferreira, Michael Fox, Noam Harel, Jona Hattangadi-Gluth, Andreas Horn, Saad Jbabdi, Joshua Kahan, Ashwini Oswal, Sameer A Sheth, Yanmei Tie, Vejay Vakharia, Ludvic Zrinzo, Harith Akram
Clinical Applications Of Magnetic Resonance Imaging Based Functional And Structural Connectivity, Chengyuan Wu, Francisca Ferreira, Michael Fox, Noam Harel, Jona Hattangadi-Gluth, Andreas Horn, Saad Jbabdi, Joshua Kahan, Ashwini Oswal, Sameer A Sheth, Yanmei Tie, Vejay Vakharia, Ludvic Zrinzo, Harith Akram
Department of Neurosurgery Faculty Papers
Advances in computational neuroimaging techniques have expanded the armamentarium of imaging tools available for clinical applications in clinical neuroscience. Non-invasive, in vivo brain MRI structural and functional network mapping has been used to identify therapeutic targets, define eloquent brain regions to preserve, and gain insight into pathological processes and treatments as well as prognostic biomarkers. These tools have the real potential to inform patient-specific treatment strategies. Nevertheless, a realistic appraisal of clinical utility is needed that balances the growing excitement and interest in the field with important limitations associated with these techniques. Quality of the raw data, minutiae of the …
Addressing Production Gaps For Vaccines In African Countries, Anna Mia Ekström, Göran Tomson, Rhoda K. Wanyenze, Zulfiqar Ahmed Bhutta, Catherine Kyobutungi, Agnes Binagwaho, Ole Petter Ottersen
Addressing Production Gaps For Vaccines In African Countries, Anna Mia Ekström, Göran Tomson, Rhoda K. Wanyenze, Zulfiqar Ahmed Bhutta, Catherine Kyobutungi, Agnes Binagwaho, Ole Petter Ottersen
Institute for Global Health and Development
No abstract provided.
Assessment Of Temporal Variations In Adherence To Nrp Using Video Recording In The Delivery Room, Amy J Sloane, Kaitlin M Kenaley, Michael T Favara
Assessment Of Temporal Variations In Adherence To Nrp Using Video Recording In The Delivery Room, Amy J Sloane, Kaitlin M Kenaley, Michael T Favara
Department of Medicine Faculty Papers
INTRODUCTION: Video recording and video evaluation tools have been successfully used to evaluate neonatal resuscitation performance. The objective of our study was to evaluate differences in Neonatal Resuscitation Program (NRP) adherence at time of birth between three temporal resuscitative periods using scored video recordings.
METHODS: This is a retrospective review of in-situ resuscitation video recordings from a level 3 perinatal center between 2017 and 2018. The modified Neonatal Resuscitation Assessment (mNRA) scoring tool was used as a surrogate marker to assess NRP adherence during daytime, evening, and nighttime hours.
RESULTS: A total of 260 resuscitations, of which 258 were births …
Spatial Proximity Matters: A Study On Collaboration, Arianna Salazar Miranda, Matthew Claudel
Spatial Proximity Matters: A Study On Collaboration, Arianna Salazar Miranda, Matthew Claudel
Geography Faculty Publications and Presentations
As scientific research becomes increasingly cross-disciplinary, many universities seek to support collaborative activity through new buildings and institutions. This study examines the impacts of spatial proximity on collaboration at MIT from 2005 to 2015. By exploiting a shift in the location of researchers due to building renovations, we evaluate how discrete changes in physical proximity affect the likelihood that researchers co-author. The findings suggest that moving researchers into the same building increases their propensity to collaborate, with the effect plateauing five years after the move. The effects are large when compared to the average rate of collaboration among pairs of …
Animal Crossing As A @Digitalaltar, Lillyanne Pham
Animal Crossing As A @Digitalaltar, Lillyanne Pham
Animal Crossing as a @DigitalAltar
Lillyanne Pham, Maria Mejia, Gavrielle Thompson, Bea Yeh, Maria Mayorya, Chanel Matsunami Govreau, virtual care lab , Roz Crews, Candace Avalos
For Fall 2021 Art & Social Practice History at Portland State University, I explored the social simulation game Animal Crossing: New Horizons (ACNH) as a digital altar. I asked How do social simulation games provide a dream space, a neighborhood btwn IRL and URL relationships? How is online gardening similar to sanctuary making, altar making? My co-conspirators offered me Fuck Tom Nook. In other words, should we build an altar in a capitalist, escapist, and colonialist dystopia? This project …
Timber Constructed: Towards An Alternative Material History, Laila Seewang, Irina Davidovici
Timber Constructed: Towards An Alternative Material History, Laila Seewang, Irina Davidovici
School of Architecture Faculty Publication and Presentations
Editorial:
This issue of Architectural Theory Review proposes an alternative intellectual history of timber architecture. It foregrounds the relationships that tie the natural resource to the cultural artefact, its processing into construction material and, with it, the production of associated disciplinary expertise. The essays explore the spatial and symbolic possibilities of timber in historical and contemporary discourse by highlighting its simultaneity as cultural artefact, material commodity, environmental resource, and structural element. Thus, the material’s appearance and representation are positioned within perennial oscillations between globalism and locality, natural and man-made, industry and craft, innovation and tradition, material and ideology, modernity and …
A Practical Extension To The Ab/Ba Design, My T.A Nguyen
A Practical Extension To The Ab/Ba Design, My T.A Nguyen
Electronic Theses and Dissertations
In this work, we take a close look at a general extension to the traditional AB/BA
crossover design that is commonly used in clinical trials to determine the effectiveness
of new candidate drugs. While the traditional crossover design requires each patient
in the study to be measured on both treatment A and treatment B, we consider the
possibility of additional measurements being available on each patient. This produces
designs such as the AABB/BBAA design which has been used in previous studies.
A general test statistic will be derived to test for treatment effects as well as its
corresponding power function …
Soil Gypsum Content Analysis Of The Proposed Road Route Extension Of Fm 2185 In The Gypsum Plain, Culberson County, Texas, Chikaodili Ohakawa
Soil Gypsum Content Analysis Of The Proposed Road Route Extension Of Fm 2185 In The Gypsum Plain, Culberson County, Texas, Chikaodili Ohakawa
Electronic Theses and Dissertations
Soils serve as the underlying substrate on which foundations for most structures are built. The properties of a soil type are therefore an important consideration in building engineered structures. Gypsic soils are problematic for construction of such structures. One of the main problems with gypsic soils is dissolution. Gypsum (CaSO4·2H2O) in soils dissolves easily creating voids which can be detrimental to the integrity of engineering structures. To mitigate this, it is important to determine the amount of gypsum present in soils, before construction is initiated.
In this study, three methods were employed in the determination of …
Widening Spinal Injury Research To Consider All Supraspinal Cell Types: Why We Must And How We Can, Murray G. Blackmore, Eliazbeth Batsel, Pantelis Tsoulfas
Widening Spinal Injury Research To Consider All Supraspinal Cell Types: Why We Must And How We Can, Murray G. Blackmore, Eliazbeth Batsel, Pantelis Tsoulfas
Biomedical Sciences Faculty Research and Publications
The supraspinal connectome consists of dozens of neuronal populations that project axons from the brain to the spinal cord to influence a wide range of motor, autonomic, and sensory functions. The complexity and wide distribution of supraspinal neurons present significant technical challenges, leading most spinal cord injury research to focus on a handful of major pathways such as the corticospinal, rubrospinal, and raphespinal. Much less is known about many additional populations that carry information to modulate or compensate for these main pathways, or which carry pre-autonomic and other information of high value to individuals with spinal injury. A confluence of …
Information Literacy For Global Inclusion: Designing An Annotated Bibliography For Global Search And Selection, Pamela A. Espinosa De Los Monteros, Elizabeth L. Black
Information Literacy For Global Inclusion: Designing An Annotated Bibliography For Global Search And Selection, Pamela A. Espinosa De Los Monteros, Elizabeth L. Black
Communications in Information Literacy
The COVID-19 pandemic has reinforced the notion that our world is global and interdependent. Despite the ever-increasing connection of global with local, there continues to be formidable barriers in accessing information produced in different international contexts and languages. This Innovative Practices article details the redesign of an annotated bibliography assignment in an international studies course to support the inclusion of global perspectives into the information practices of undergraduate students. The redesign embedded explicit information literacy dispositions and global citizenship education competencies through the search and selection of global information sources. The authors discuss the instructional elements used, student outcomes, and …
Remote Reference Consultations Are Here To Stay, Emily Reed
Remote Reference Consultations Are Here To Stay, Emily Reed
Communications in Information Literacy
Remote reference consultations have considerably increased due to the need to provide remote services during the COVID-19 pandemic. Conducting reference consultations via videoconferencing not only offers many benefits to student researchers it also presents an opportunity for librarians to embrace a learner-centered teaching mindset when approaching remote consultations by developing consultation learning goals in alignment with the Framework for Information Literacy for Higher Education. Designing consultations to be learner-centered yields benefits for students such as the student actively practicing their own searches as well as more thorough source evaluation. Additionally, videoconferencing technology allows for a more seamless information sharing …
A Perfect Meal, Stewart Brower
A Perfect Meal, Stewart Brower
Communications in Information Literacy
No abstract provided.
Beam Me Up: Teaching Rhetorical Methods For Source Use And Synthesis, Ashley Roach-Freiman
Beam Me Up: Teaching Rhetorical Methods For Source Use And Synthesis, Ashley Roach-Freiman
Communications in Information Literacy
BEAM is a schema for categorizing the rhetorical positions of authors according to the author’s intention or purpose of the information. The author critiques common methods of teaching source evaluation and proposes that instruction librarians teach BEAM to students who may struggle using a source once they have located it. A lesson plan is included as supplemental materials.
The Preconstruction Of Foundation For A Greenhouse, Alla I. Hashim
The Preconstruction Of Foundation For A Greenhouse, Alla I. Hashim
Construction Management
This project outlines the preconstruction process for building a concrete base for a prefabricated greenhouse unit. This project was initiated by the Cal Poly Garden Club so they could plan for the installation of a greenhouse at the Student Experimental Farm on Cal Poly’s campus. The members of the club currently share a greenhouse with another Cal Poly Club which restricts their ability to use the greenhouse freely. The initial goal of the project was to request a permit, however, that will be postponed until the specific location is determined. This project still provides the necessary elements for requesting a …
A Safety Factor Approach To Designing Urban Infrastructure For Dynamic Conditions, Sanjib Sharma, Ben Seiyon Lee, Robert E. Nicholas, Klaus Keller
A Safety Factor Approach To Designing Urban Infrastructure For Dynamic Conditions, Sanjib Sharma, Ben Seiyon Lee, Robert E. Nicholas, Klaus Keller
Dartmouth Scholarship
Current approaches to design flood-sensitive infrastructure typically assume a stationary rainfall distribution and neglect many uncertainties. These assumptions are inconsistent with observations that suggest intensifying extreme precipitation events and the uncertainties surrounding projections of the coupled natural-human systems. Here we demonstrate a safety factor approach to designing urban infrastructure in a changing climate. Our results show that assuming climate stationarity and neglecting deep uncertainties can drastically underestimate flood risks and lead to poor infrastructure design choices. We find that climate uncertainty dominates the socioeconomic and engineering uncertainties that impact the hydraulic reliability in stormwater drainage systems. We quantify the upfront …
Γδ T Cell Ifnγ Production Is Directly Subverted By Yersinia Pseudotuberculosis Outer Protein Yopj In Mice And Humans, Timothy H. Chu, Camille Khairallah, Jason Shieh, Rhea Cho, Zhijuan Qiu, Yue Zhang, Onur Eskiocak, David G. Thanassi, Mark H. Kaplan, Semir Beyaz, Vincent W. Yang, James B. Bliska, Brian S. Sheridan
Γδ T Cell Ifnγ Production Is Directly Subverted By Yersinia Pseudotuberculosis Outer Protein Yopj In Mice And Humans, Timothy H. Chu, Camille Khairallah, Jason Shieh, Rhea Cho, Zhijuan Qiu, Yue Zhang, Onur Eskiocak, David G. Thanassi, Mark H. Kaplan, Semir Beyaz, Vincent W. Yang, James B. Bliska, Brian S. Sheridan
Dartmouth Scholarship
Yersinia pseudotuberculosis is a foodborne pathogen that subverts immune function by translocation of Yersinia outer protein (Yop) effectors into host cells. As adaptive γδ T cells protect the intestinal mucosa from pathogen invasion, we assessed whether Y. pseudotuberculosis subverts these cells in mice and humans. Tracking Yop translocation revealed that the preferential delivery of Yop effectors directly into murine Vγ4 and human Vδ2+ T cells inhibited anti-microbial IFNγ production. Subversion was mediated by the adhesin YadA, injectisome component YopB, and translocated YopJ effector. A broad anti-pathogen gene signature and STAT4 phosphorylation levels were inhibited by translocated YopJ. Thus, Y. pseudotuberculosis …
Associations Between Postpartum Depression And Assistance With Household Tasks And Childcare During The Covid-19 Pandemic: Evidence From American Mothers, Theresa E. Gildner, Glorieuse Uwizeye, Rebecca L. Milner, Grace C. Alston, Zaneta M. Thayer
Associations Between Postpartum Depression And Assistance With Household Tasks And Childcare During The Covid-19 Pandemic: Evidence From American Mothers, Theresa E. Gildner, Glorieuse Uwizeye, Rebecca L. Milner, Grace C. Alston, Zaneta M. Thayer
Dartmouth Scholarship
Background: The early postpartum period is recognized cross-culturally as being important for recovery, with new parents receiving increased levels of community support. However, COVID-19-related lockdown measures may have disrupted these support systems, with possible implications for mental health. Here, we use a cross-sectional analysis among individuals who gave birth at different stages of the pandemic to test (i) if instrumental support access in the form of help with household tasks, newborn care, and care for older children has varied temporally across the pandemic, and (ii) whether access to these forms of instrumental support is associated with lower postpartum depression scores. …
Integrating Satellite, Uav, And Ground-Based Remote Sensing In Archaeology: An Exploration Of Pre-Modern Land Use In Northeastern Iraq, Elise Jakoby Laugier, Jesse Casana
Integrating Satellite, Uav, And Ground-Based Remote Sensing In Archaeology: An Exploration Of Pre-Modern Land Use In Northeastern Iraq, Elise Jakoby Laugier, Jesse Casana
Dartmouth Scholarship
Satellite remote sensing is well demonstrated to be a powerful tool for investigating ancient land use in Southwest Asia. However, few regional studies have systematically integrated satellite-based observations with more intensive remote sensing technologies, such as drone-deployed multispectral sensors and ground-based geophysics, to explore off-site areas. Here, we integrate remote sensing data from a variety of sources and scales including historic aerial photographs, modern satellite imagery, drone-deployed sensors, and ground-based geophysics to explore pre-modern land use along the Upper Diyala/Sirwan River in the Kurdistan Region of Iraq. Our analysis reveals an incredible diversity of land use features, including canals, qanats, …
Maternal Depression Trajectories And Child Bmi In A Multi-Ethnic Sample: A Latent Growth Modeling Analysis, Charlotte V. Farewell, Ryley Donohoe, Zaneta Thayer, James Paulson, Jacinda Nicklas, Caroline Walker, Karen Waldie, Jenn A. Leiferman
Maternal Depression Trajectories And Child Bmi In A Multi-Ethnic Sample: A Latent Growth Modeling Analysis, Charlotte V. Farewell, Ryley Donohoe, Zaneta Thayer, James Paulson, Jacinda Nicklas, Caroline Walker, Karen Waldie, Jenn A. Leiferman
Dartmouth Scholarship
Background: Perinatal (antenatal and postpartum) depression impacts approximately 12% of mothers. Perinatal depression can impact everyday functioning for mothers, and the relationship with, and development of, their children. The purpose of this study was to investigate depression trajectories from the antenatal period through 54-months postpartum and associations with child body mass index at 54-months postpartum. Methods: This study applied latent growth modeling to the Growing Up in New Zealand study, which is a longitudinal pregnancy cohort study that provides nationally representative-level data, to investigate associations between depression at three time points (antenatal, 9-months postpartum, 54-months postpartum) and child body mass …
Ct For Estimating Adequacy Of Lymph Node Dissection In Patients With Squamous Cell Carcinoma Of The Head And Neck, Christiaan A. Rees, Joshua H. Litchman, Xiaotian Wu, Mariah M. Servos, Darcy A. Kerr, Ryan J. Halter, David A. Pastel, Joseph A. Paydarfar
Ct For Estimating Adequacy Of Lymph Node Dissection In Patients With Squamous Cell Carcinoma Of The Head And Neck, Christiaan A. Rees, Joshua H. Litchman, Xiaotian Wu, Mariah M. Servos, Darcy A. Kerr, Ryan J. Halter, David A. Pastel, Joseph A. Paydarfar
Dartmouth Scholarship
Background: Indices obtained from lymph node dissection specimens, specifically lymph node yield (LNY) and lymph node ratio (LNR), have prognostic significance in the setting of head and neck squamous cell carcinoma (HNSCCa). However, there are currently no validated tools to estimate adequacy of planned lymph node dissection using preoperative data. The present study sought to evaluate CT-derived estimates of lymphatic tissue volumes as a preoperative tool to guide cervical node dissection. Methods: Fifteen cervical lymph node dissections were performed in 14 subjects with HNSCCa. Preoperative CT-derived estimates of lymphatic tissue volumes were compared with gross pathology tissue volume estimates and …
A Distributed Fmri-Based Signature For The Subjective Experience Of Fear, Feng Zhou, Weihua Zhao, Ziyu Qi, Yayuan Geng, Shuxia Yao, Keith M. Kendrick, Tor D. Wager, Benjamin Becker
A Distributed Fmri-Based Signature For The Subjective Experience Of Fear, Feng Zhou, Weihua Zhao, Ziyu Qi, Yayuan Geng, Shuxia Yao, Keith M. Kendrick, Tor D. Wager, Benjamin Becker
Dartmouth Scholarship
The specific neural systems underlying the subjective feeling of fear are debated in affective neuroscience. Here, we combine functional MRI with machine learning to identify and evaluate a sensitive and generalizable neural signature predictive of the momentary self-reported subjective fear experience across discovery (n = 67), validation (n = 20) and generalization (n = 31) cohorts. We systematically demonstrate that accurate fear prediction crucially requires distributed brain systems, with important contributions from cortical (e.g., prefrontal, midcingulate and insular cortices) and subcortical (e.g., thalamus, periaqueductal gray, basal forebrain and amygdala) regions. We further demonstrate that the neural representation of subjective fear …
Spectral Analysis Of Climate Dynamics With Operator-Theoretic Approaches, Gary Froyland, Dimitrios Giannakis, Benjamin R. Lintner, Maxwell Pike, Joanna Slawinska
Spectral Analysis Of Climate Dynamics With Operator-Theoretic Approaches, Gary Froyland, Dimitrios Giannakis, Benjamin R. Lintner, Maxwell Pike, Joanna Slawinska
Dartmouth Scholarship
The Earth’s climate system is a classical example of a multiscale, multiphysics dynamical system with an extremely large number of active degrees of freedom, exhibiting variability on scales ranging from micrometers and seconds in cloud microphysics, to thousands of kilometers and centuries in ocean dynamics. Yet, despite this dynamical complexity, climate dynamics is known to exhibit coherent modes of variability. A primary example is the El Niño Southern Oscillation (ENSO), the dominant mode of interannual (3–5 yr) variability in the climate system. The objective and robust characterization of this and other important phenomena presents a long-standing challenge in Earth system …
Color Cherenkov Imaging Of Clinical Radiation Therapy, Daniel A. Alexander, Anthony Nomezine, Lesley A. Jarvis, David J. Gladstone, Brian W. Pogue, Petr Bruza
Color Cherenkov Imaging Of Clinical Radiation Therapy, Daniel A. Alexander, Anthony Nomezine, Lesley A. Jarvis, David J. Gladstone, Brian W. Pogue, Petr Bruza
Dartmouth Scholarship
Color vision is used throughout medicine to interpret the health and status of tissue. Ionizing radiation used in radiation therapy produces broadband white light inside tissue through the Cherenkov effect, and this light is attenuated by tissue features as it leaves the body. In this study, a novel time-gated three-channel camera was developed for the first time and was used to image color Cherenkov emission coming from patients during treatment. The spectral content was interpreted by comparison with imaging calibrated tissue phantoms. Color shades of Cherenkov emission in radiotherapy can be used to interpret tissue blood volume, oxygen saturation and …
Developing Diagnostic Assessment Of Breast Lumpectomy Tissues Using Radiomic And Optical Signatures, Samuel S. Streeter, Brady Hunt, Rebecca A. Zuurbier, Wendy A. Wells, Keith D. Paulsen, Brian W. Pogue
Developing Diagnostic Assessment Of Breast Lumpectomy Tissues Using Radiomic And Optical Signatures, Samuel S. Streeter, Brady Hunt, Rebecca A. Zuurbier, Wendy A. Wells, Keith D. Paulsen, Brian W. Pogue
Dartmouth Scholarship
High positive margin rates in oncologic breast-conserving surgery are a pressing clinical problem. Volumetric X-ray scanning is emerging as a powerful ex vivo specimen imaging technique for analyzing resection margins, but X-rays lack contrast between non-malignant and malignant fibrous tissues. In this study, combined micro-CT and wide-field optical image radiomics were developed to classify malignancy of breast cancer tissues, demonstrating that X-ray/optical radiomics improve malignancy classification. Ninety-two standardized features were extracted from co-registered micro-CT and optical spatial frequency domain imaging samples extracted from 54 breast tumors exhibiting seven tissue subtypes confirmed by microscopic histological analysis. Multimodal feature sets improved classification …
Diverse Antiviral Igg Effector Activities Are Predicted By Unique Biophysical Antibody Features, Hao D. Cheng, Karen G. Dowell, Chris Bailey-Kellogg, Brittany A. Goods, J. Christopher Love, Guido Ferrari, Galit Alter, Johannes Gach, Donald N. Forthal, George K. Lewis, Kelli Greene, Hongmei Gao, David C. Montefiori, Margaret E. Ackerman
Diverse Antiviral Igg Effector Activities Are Predicted By Unique Biophysical Antibody Features, Hao D. Cheng, Karen G. Dowell, Chris Bailey-Kellogg, Brittany A. Goods, J. Christopher Love, Guido Ferrari, Galit Alter, Johannes Gach, Donald N. Forthal, George K. Lewis, Kelli Greene, Hongmei Gao, David C. Montefiori, Margaret E. Ackerman
Dartmouth Scholarship
Background: The critical role of antibody Fc-mediated effector functions in immune defense has been widely reported in various viral infections. These effector functions confer cellular responses through engagement with innate immune cells. The precise mechanism(s) by which immunoglobulin G (IgG) Fc domain and cognate receptors may afford protection are poorly understood, however, in the context of HIV/SHIV infections. Many different in vitro assays have been developed and utilized to measure effector functions, but the extent to which these assays capture distinct antibody activities has not been fully elucidated. Results: In this study, six Fc-mediated effector function assays and two biophysical …