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2021

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Seeking Truth About Muslims: Critical Media Literacies In An Era Of Islamophobia, Matthew Deroo Dec 2021

Seeking Truth About Muslims: Critical Media Literacies In An Era Of Islamophobia, Matthew Deroo

Journal of Media Literacy Education

Across various forms of media, Muslims are often portrayed as a homogenous group prone to violence, yet scholars have increasingly called upon schools and teachers to transcend stereotypes and prepare students to understand Muslims in more thoughtful and nuanced ways. This qualitative case study recounts how students and a teacher in a high school multicultural studies class investigated problematic media materials about Islam sent by an organization called the Christian Seniors Association. Drawing upon Mihailidis’s (2014) 5A’s of Media Literacy heuristic, I analyzed field notes from classroom observations, interviews, and student produced artifacts. Findings revealed how a teacher’s use of …


“Draw The Internet”: A Visual Exploration Of How Children Imagine An Everyday Technology, Luca A. Botturi Dec 2021

“Draw The Internet”: A Visual Exploration Of How Children Imagine An Everyday Technology, Luca A. Botturi

Journal of Media Literacy Education

The internet is today a significant part of children’s daily lives, and digital competences have been included as basic learning goals in many school systems worldwide. In order to develop sound and effective early-age internet education programs, information about how children use the internet should be integrated with insights in how they understand it. This study investigates 8-to-10-year-old children’s understanding of the internet through the qualitative analysis of 51 drawings collected in three primary school classes in Switzerland. The results confirm that children’s conceptions of the internet are rich but often inaccurate or uncomplete. The conceptions collected in this study …


Media, Obesity Discourse, And Participatory Politics: Exploring Digital Engagement Among University Students, Tao Papaioannou Dec 2021

Media, Obesity Discourse, And Participatory Politics: Exploring Digital Engagement Among University Students, Tao Papaioannou

Journal of Media Literacy Education

Situated within research on youth, participatory politics, and media framing of obesity, this study examined how undergraduate students in a media literacy course engaged with obesity discourse as a nexus of civic participation. Twenty-nine students enrolled on the course identified frames of obesity in plus-size model Tess Holliday’s Instagram posts surrounding her controversial Cosmopolitan cover in 2018. Analysis of these frames – self-validation, injustice of fat-shaming and stigmatization, influences of Instagram celebrities on fat embodiment, and health stereotypes of obese people – enabled the students to critique activist responses to accepted body norms and moral values facilitating weight bias. In …


Conceptions Of Adult Education Teachers-In-Training Regarding The Media Literacy Education Of Older People. A Phenomenographic Study To Inform A Course Design, Hanna Vuojärvi, Sirpa Purtilo-Nieminen, Päivi Rasi, Susanna Rivinen Dec 2021

Conceptions Of Adult Education Teachers-In-Training Regarding The Media Literacy Education Of Older People. A Phenomenographic Study To Inform A Course Design, Hanna Vuojärvi, Sirpa Purtilo-Nieminen, Päivi Rasi, Susanna Rivinen

Journal of Media Literacy Education

This phenomenographic study represents part of an ongoing design-based research initiative to inform the design of a new course on older people’s media literacy in the adult-education teacher-education context. The aim was to describe the conceptions of teachers-in-training regarding media literacy education for older people. The data consist of students’ written assignments in which they defined the concept of older people, their societal roles, and of the media literacy education targeting them. The participants included teachers-in-training (N = 22) from a Finnish university’s teacher education program. The data were analyzed qualitatively with the aim of exploring how these students …


Numerical Investigation On The Effect Of Spectral Radiative Heat Transfer Within An Ablative Material, Raghava S. C. Davuluri, Rui Fu, Kaveh A. Tagavi, Alexandre Martin Dec 2021

Numerical Investigation On The Effect Of Spectral Radiative Heat Transfer Within An Ablative Material, Raghava S. C. Davuluri, Rui Fu, Kaveh A. Tagavi, Alexandre Martin

Mechanical Engineering Faculty Publications

The spectral radiative heat flux could impact the material response. In order to evaluate it, a coupling scheme between KATS - MR and P1 approximation model of radiation transfer equation (RTE) is constructed and used. A Band model is developed that divides the spectral domain into small bands of unequal widths. Two verification studies are conducted: one by comparing the simulation computed by the Band model with pure conduction results and the other by comparing with similar models of RTE. The comparative results from the verification studies indicate that the Band model is computationally efficient and can be used to …


Data Protection - Ethical Challenges During The Covid-19 Pandemic, Feruza S. Atamuratova, Sarvinoz G. Rakhmanova Dec 2021

Data Protection - Ethical Challenges During The Covid-19 Pandemic, Feruza S. Atamuratova, Sarvinoz G. Rakhmanova

Central Asian Journal of Medicine

It's no secret that with the development of information technology, many ethical problems of biomedicine have become aggravated. This is especially true of the issue of medical secrecy and protection of patient data. Digital medicine requires the opposite specifically in emergency situations: to disclose all the data concerning the course of the disease in order to reduce its further spread. Every day we read or watch videos from all over the world in the media about sick people and how their diseases are progressing during the COVID-19 pandemic. Confidentiality protection of personal data, information and software support of the user, …


Complications Of Extracorporeal Shock -Wave Lithotripsy And Their Systematization, Farkhad A. Akilov, Shukhrat I. Giyasov, Akmal R. Ruzibaev, Askar A. Rakhimbaev Dec 2021

Complications Of Extracorporeal Shock -Wave Lithotripsy And Their Systematization, Farkhad A. Akilov, Shukhrat I. Giyasov, Akmal R. Ruzibaev, Askar A. Rakhimbaev

Central Asian Journal of Medicine

The aim of study was to study the effectiveness of extracorporeal shock-wave lithotripsy and assess its post-procedural complications. Materials and methods. The results of treatment of 200 patients with urolithiasis who were admitted to the Republican Specialized Scientific-Practical Medical Center of Urology in the period 2019-2020 that have been exposed to ESWL because of upper urinary tract (UT) stone(s) prospectively were analyzed. The mean patients' age was 39.7 ± 14.7, BMI - 25.5 ± 4.8 (kg / m2). The affected side: 103 (51.5%) on the right, 97 (48.5%) on the left. The average stone size was 9.0 ± 0.2 (mm), …


Improvement Of Practical Skills On The Basis Of Innovative Approach To Medical Education, Lola A. Abduraximova Dec 2021

Improvement Of Practical Skills On The Basis Of Innovative Approach To Medical Education, Lola A. Abduraximova

Central Asian Journal of Medicine

This article discusses the importance of simulation training in teaching practical skills in the training of future medical staff. The study evaluated the effectiveness of teaching using traditional teaching methods and simulators. Information on specific aspects of simulation training is provided.


Assessment Of The Level Of Compliance Of Women Of Uzbekistan With A Healthy Lifestyle, Durdona M. Akhmedova, Adiba A. Usmankhodjaeva, Ulugbek A. Sharipov Dec 2021

Assessment Of The Level Of Compliance Of Women Of Uzbekistan With A Healthy Lifestyle, Durdona M. Akhmedova, Adiba A. Usmankhodjaeva, Ulugbek A. Sharipov

Central Asian Journal of Medicine

In January 2021, in order to assess the level of healthy living of the women of Uzbekistan, i.e. the observance of a healthy lifestyle, to identify many common diseases and problems among women, we conducted mass medical examinations (anthropometric examinations) among women in Namangan and and Andijan cities. 276 women (aged 46-74 years) took part in the medical examination. We have studied all 276 women with age, gender, hereditary diseases, concomitant diseases, and have analyzed and evaluated them based on several principles. We put the data obtained into tables and diagrams so that it is easy to analyze. From the …


Development Of An Innovative Computer-Information Apparatus For Designing And Implementing An Integrated Model Of Training And Activity Of A Specialist In Medical Universities, Axmat F. Marasulov, Muratali I. Bazarbayev, Erkinbay Ya. Ermetov Dec 2021

Development Of An Innovative Computer-Information Apparatus For Designing And Implementing An Integrated Model Of Training And Activity Of A Specialist In Medical Universities, Axmat F. Marasulov, Muratali I. Bazarbayev, Erkinbay Ya. Ermetov

Central Asian Journal of Medicine

It is proposed to develop an integrated model of training a future specialist based on the construction and implementation of: an integrated conceptual and theoretical apparatus for the activities of a teacher and a student, a functionally task-oriented hierarchical system of an educational and methodological knowledge base and a database for training a specialist, department computer and information technology for managing the training of a future specialist. Computer-information technology of the integrated apparatus of conceptual and theoretical activity of the teacher and student, based on the disclosure of the content and structure of methodological knowledge of the teacher associated with …


Pre-Operative Training Of Patients With Osteoporosis During Premenopause When Planning Dental Implantation (Review Article), Barno J. Pulatova, Nodira G. Achilova Dec 2021

Pre-Operative Training Of Patients With Osteoporosis During Premenopause When Planning Dental Implantation (Review Article), Barno J. Pulatova, Nodira G. Achilova

Central Asian Journal of Medicine

The article describes materials on the literature review on the preparation of patients with osteoporosis in the climacteric period when planning implantation. The clinical significance of osteoporosis in the climacteric period lies in the leaching of calcium from the bone into the blood, which makes it possible to minimize the negative influence of the human factor., The high percentage of patients of older age groups, especially women, for the elimination of defects in the dentition with the help of dental implants makes it possible to consider this problem especially relevant, since the asymptomatic, inexpressive course of osteoporosis can be the …


Modern Methods For Diagnosing Disorders Of Kidney Function, N. Kh. Mukhamedova, U.P. Shukurova, M.R. Sobirova Dec 2021

Modern Methods For Diagnosing Disorders Of Kidney Function, N. Kh. Mukhamedova, U.P. Shukurova, M.R. Sobirova

Central Asian Journal of Medicine

In modern urological practice, various modern research methods, the latest devices and instruments are used to diagnose diseases of the genitourinary system. The introduction of highly informative methods of radiation diagnostics: ultrasound scanning, computed and magnetic resonance imaging - allows detecting kidney diseases at an early stage.


The Impact Of Sequelae Of Covid-19 On The Course Of Ankylosing Spondylitis, Madina B. Rakhimova, Khalmurad S. Akhmedov Dec 2021

The Impact Of Sequelae Of Covid-19 On The Course Of Ankylosing Spondylitis, Madina B. Rakhimova, Khalmurad S. Akhmedov

Central Asian Journal of Medicine

Purpose. The purpose of the research was to study the clinical features of the course of ankylosing spondylitis: functional activity, dynamics of inflammation markers and other disorders in patients in the post COVID period. Materials and methods. The research included 50 patients with ankylosing spondylitis who had undergone COVID-19 and 20 patients who did not have a history of COVID-19. All patients underwent an assessment on the BASDAI, BASFI, ASDAS, VAS (pain) scales, as well as biochemical, immunological, instrumental (X-ray, MRI of the pelvis and spine, ECG, ECHOCG) investigations. Results. High indices of Lansbury, BASDAI, BASFI, ASDAS and VAS scales …


Features Of Dermatological Manifestations After Coronavirus Infection In Patients With Previously Intact Skin, Umida A. Tashkenbaeva, Guzal D. Klebleeva Dec 2021

Features Of Dermatological Manifestations After Coronavirus Infection In Patients With Previously Intact Skin, Umida A. Tashkenbaeva, Guzal D. Klebleeva

Central Asian Journal of Medicine

Being a relatively new pathology, coronavirus infection, due to the multiple organ damage to the body, has many clinical manifestations, including dermatological ones, the study of which is still the subject of research. Since its spread, there have been very few reports of dermatological manifestations of COVID-19 and its cutaneous manifestations in the community. Purpose of the study: is to identify the features of the clinical course of dermatological manifestations in patients who have undergone coronavirus infection. Materials and methods: The study included 108 patients who underwent a comprehensive examination and treatment in the Samarkand regional dermatovenerologic dispensary from July …


Epidemiological Features Of Hiv / Tb Coinfection In The Republic Of Karakalpakstan, Amanturdi Mirtazaev, Gulbaxor S. Matnazarova, Kamila T. Ubbiniyazova, Dilbar M. Urunova Dec 2021

Epidemiological Features Of Hiv / Tb Coinfection In The Republic Of Karakalpakstan, Amanturdi Mirtazaev, Gulbaxor S. Matnazarova, Kamila T. Ubbiniyazova, Dilbar M. Urunova

Central Asian Journal of Medicine

Tuberculosis is the leading secondary disease in patients with HIV infection. The article presents the materials of the study of the tendency of the epidemiological process of various forms of tuberculosis in HIV-infected patients in the administrative-territorial zones of the Republic of Karakalpakstan for the period 2010-2020.


Disfunction Of Vascular Endothelium As A Pathogenetic Factor Of The Development Of Thrombophilic Conditions In Chronic Obstructive Pulmonary Disease (Review), Elnora A. Abduganieva, Irina V. Liverko, Rano K. Dadabaeva Dec 2021

Disfunction Of Vascular Endothelium As A Pathogenetic Factor Of The Development Of Thrombophilic Conditions In Chronic Obstructive Pulmonary Disease (Review), Elnora A. Abduganieva, Irina V. Liverko, Rano K. Dadabaeva

Central Asian Journal of Medicine

In world medicine, the problem of cardiopulmonary comorbidity, including the development of thrombotic cardiovascular catastrophes against the background of chronic obstructive pulmonary disease (COPD), is becoming increasingly important. Endothelial dysfunction, developing as a result of changes in the underlying pathogenesis of COPD, can increase the predisposition to cardiovascular complications - thrombosis in this group of patients. The purpose. The aim of this study was to analyze the available scientific data on the possible role of endothelial dysfunction in the high incidence of thrombotic complications in COPD. Material and research methods. The research material was the open access scientific literature of …


Coronavirus Pneumonia Induced Lung Abscess: Case Report, Oktyabr R. Teshaev, Gulbahor E. Rakhmonova, Мokhinur А. Khamidova, Dinara Z. Uktamova Dec 2021

Coronavirus Pneumonia Induced Lung Abscess: Case Report, Oktyabr R. Teshaev, Gulbahor E. Rakhmonova, Мokhinur А. Khamidova, Dinara Z. Uktamova

Central Asian Journal of Medicine

The COVID-19 has been confirmed to spread from person to person, mainly transmitting through respiratory secretions or direct contact. At present, the diagnosis of COVID-19 pneumonia is based on clinical symptoms, contact history of epidemic area, imaging diagnosis, and nucleic acid detection. However, false negative in nucleic acid detection has been reported, and the clinical symptoms may be atypical that may cause misdiagnosis and make the situation spread. Therefore, the imaging examination becomes particularly important [1]. Incubation period for COVID-19 is usually is 3-7 days, but not more than 14 days, contamination occurs during the incubation period. The main symptoms …


Results Of Morphological Studies Of Various Forms Of Chronic Tonsillitis, Firdavs N. Nordjigitov, Jamolbek A. Djuraev Dec 2021

Results Of Morphological Studies Of Various Forms Of Chronic Tonsillitis, Firdavs N. Nordjigitov, Jamolbek A. Djuraev

Central Asian Journal of Medicine

Traditionally, the diagnosis of chronic tonsillitis is based on the assessment of clinical signs. It should also be born in mind that the morphological examination of the tonsils is an invasive method and can only be used to confirm the diagnosis after tonsillectomy, and not as a routine examination of patients with chronic tonsillitis. Morphological changes in palatine tonsils during chronic tonsillitis are represented by the proliferation of connective tissue in the thickness of the lymphoid tissue, the presence of necrotic foci, damage to the walls of capillary vessels, and disturbances in the crypt epithelium. In the case of the …


Molecular-Genetic Basis In The Pathogenesis Of Nosological Synthropy Of Gallstone Disease And Metabolic Syndrome, Uktam S. Ismailov, Davron Yu. Batirov, Kodirjon T. Boboev, Anvar P. Rakhimov Dec 2021

Molecular-Genetic Basis In The Pathogenesis Of Nosological Synthropy Of Gallstone Disease And Metabolic Syndrome, Uktam S. Ismailov, Davron Yu. Batirov, Kodirjon T. Boboev, Anvar P. Rakhimov

Central Asian Journal of Medicine

Currently, there is a steady trend towards an increase in the number of patients with gallstone disease and metabolic syndrome. The two diseases share several risk factors in common, including age, gender, being overweight, and impaired lipid and glucose metabolism. In the pathogenesis, the development of gallstone disease and metabolic syndrome plays an important role in the violation of lipid metabolism. Lipid metabolism disorders are primarily characterized by an increase in cholesterol and triglyceride levels in the blood. The primary cause of lipid metabolism disorders is hereditary - a genetic factor. Purpose of the study: To study the role of …


Study Of Hygienic Aspects Of Working Conditions Of Pharmaceutical Companies’ Employees, Guzal T. Iskandarova, Munisa N. Tashpulatova, Shakhnoza I. Kurbanova, Guzal F. Sherkuzieva Dec 2021

Study Of Hygienic Aspects Of Working Conditions Of Pharmaceutical Companies’ Employees, Guzal T. Iskandarova, Munisa N. Tashpulatova, Shakhnoza I. Kurbanova, Guzal F. Sherkuzieva

Central Asian Journal of Medicine

In Uzbekistan, special attention is paid to the production of medicinal preparations from local plant raw materials. Taking into account the existence of a rich market of plant raw materials in Uzbekistan, hygienists must to develop measures to improve health of employees in modern pharmaceutical enterprises and assess the working conditions.In addition, pharmaceutical enterprises are characterized by the use of a wide range of inorganic and organic chemicals, obtained by natural and organic synthesis.In such manufacturing enterprises, the preparation of medicines is a prolonged process that takes into account raw materials, including substances derived from plants, reagents, many times loading …


Approach To Acute Coronary Syndrome In Covid-19 Infection, Nargiza М. Nurillaeva, Munisakhon M. Makhkamova Dec 2021

Approach To Acute Coronary Syndrome In Covid-19 Infection, Nargiza М. Nurillaeva, Munisakhon M. Makhkamova

Central Asian Journal of Medicine

The purpose is to study the occurrence of acute cardiovascular complications in COVID-19 infection and to compare their clinical manifestation with cases which are not connected with coronavirus disease. To choose the most compatible tactics for acute coronary syndrome during covid and post- covid period. Material and research methods. This study is a retrospective cohort study of 150 hospitalized patients with COVID-19 in a TMA multidisciplinary clinic and the cardiac intensive care unit of the Republican Scientific and Practical Medical Center of Cardiology from October, 2020 to September, 2021. A total of 106 patients with confirmed ACS (Acute coronary syndrome) …


Epidemiology Of Benign Prostate Hyperplasia And The Importance Of Risk Factors In The Development Of Pathology (On The Example Of Andijan), Alisher A. Shadmanov, Akramjon R. Saliev, Feruza I. Salomova Dec 2021

Epidemiology Of Benign Prostate Hyperplasia And The Importance Of Risk Factors In The Development Of Pathology (On The Example Of Andijan), Alisher A. Shadmanov, Akramjon R. Saliev, Feruza I. Salomova

Central Asian Journal of Medicine

Aim of the study: the prevalence of benign prostate hyperplasia and the importance of risk factors in the development of pathology among the unorganized male population in Andijan was analyzed. Materials and methods: the total volume of the competition was 2702 people, and the survey coverage was 1977 people (72.3%). Conclusions: benign prostatic hyperplasia was registered in 844 (42.7%) people, the lowest rate was in the age group 30-39 years old, and the highest in the age group 50-59 years old (28.4%). The results of the assessment of the main risk factors for the development of prostatic hyperplasia showed that …


Herpesvirus Infections In Hiv-Infected Patients In The Republic Of Karakalpakstan, G.S. Matnazarova, D.M. Urunova, S.Zh. Kadirbergenova, E.V. Bryantseva Dec 2021

Herpesvirus Infections In Hiv-Infected Patients In The Republic Of Karakalpakstan, G.S. Matnazarova, D.M. Urunova, S.Zh. Kadirbergenova, E.V. Bryantseva

Central Asian Journal of Medicine

The paper provides data on the frequency of occurrence of various forms of herpesvirus infections in HIV-infected patients registered at the Republican AIDS Center in the Republic of Karakalpakstan. The results of the study showed a wide spread of HIV infection among patients under 50 years of age. Various herpetic infections were identified in 27.5% of patients. Among all types of herpesvirus infections, diseases caused by the varicella zoster virus (VVZ) (51.0%) and herpes simplex virus type 1 (HSV type 1) (43.0%) prevailed.


Splenectomy For Hairy Cell Leukemia, Gaybulla I. Mustafakulov, Ulugbek Y. Ergashev, Аlisher T. Muminov, Davron R. Yakubov Dec 2021

Splenectomy For Hairy Cell Leukemia, Gaybulla I. Mustafakulov, Ulugbek Y. Ergashev, Аlisher T. Muminov, Davron R. Yakubov

Central Asian Journal of Medicine

This work presents observation data for 16 patients with hairy cell leukemia (HCL), the duration of the disease ranged from 1 to 15 years. The indications for surgery in case of ON and the results of splenectomy in 5 patients are presented. No complications from operations were observed. After splenectomy, the patients' condition improved platelets, blood retraction normalized, hemoglobin and erythrocytes rose in dynamics, hemorrhagic syndrome disappeared, hemodynamics stabilized. Despite the positive clinical and laboratory effect after splenectomy for a year, the further prognosis of the disease remains serious and patients need constant dispensary observation.


Study Of Apparent Molar Volumes Of Electrolyte Solutions And Its Application In Medicine, Muratali I. Bazarbayev, Qumrijon I. Narziqulova, Islom Mullojonov, Erkinbay Ya. Ermetov Dec 2021

Study Of Apparent Molar Volumes Of Electrolyte Solutions And Its Application In Medicine, Muratali I. Bazarbayev, Qumrijon I. Narziqulova, Islom Mullojonov, Erkinbay Ya. Ermetov

Central Asian Journal of Medicine

All biological processes in plant or animal organisms, including in the human body, are carried out in solutions. Therefore, the progress of sciences such as biology, medicine, etc., is closely related to the development of the doctrine of solutions. When dissolved, various chemical interactions occur between the components and due to Van der Waals force, etc. One of the methods for determining the ion molecular interaction is the study of the partial molar volume of electrolytes.


2021-12-29_Michigandaily_Covidmap, Michigan Department Of Health & Human Services Dec 2021

2021-12-29_Michigandaily_Covidmap, Michigan Department Of Health & Human Services

Daily Michigan COVID-19 Update

The "WHERE WE STAND WITH COVID-19" map was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily at 3p.m., Monday - Saturday.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled.

The image contained a map, indicating total cases by county, and also provides statistics on Total Confirmed Cases, Total COVID-19 Deaths, Daily Confirmed Cases, and Daily COVID-19 Deaths. There …


A Scoping Review To Inform Care Coordination Strategies For Youth With Traumatic Brain Injuries: Care Coordination Tools, Brandy Shook, Cara Palusak, Susan C. Davies, Jennifer P. Lundine Dec 2021

A Scoping Review To Inform Care Coordination Strategies For Youth With Traumatic Brain Injuries: Care Coordination Tools, Brandy Shook, Cara Palusak, Susan C. Davies, Jennifer P. Lundine

Counselor Education and Human Services Faculty Publications

BACKGROUND: Children with traumatic brain injury (TBI) report unmet needs several years after their injury and may require long-term care. However, this chronic health condition is often only treated and monitored in the short-term. Care for young persons with TBI often relies on parents to manage their child’s complex care network. Effective care coordination can close these gaps and facilitate continuity of care for children with TBI. The purpose of this scoping review was to develop a better understanding of tools that improve care coordination for Children with Special Health Care Needs (CSHCN). This, in turn, can inform care for …


2021-12-29_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services Dec 2021

2021-12-29_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services

Cumulative Michigan COVID-19 Data

The COVID Overview page was obtained from Michigan's main COVID-19 page: https:/www.michigan.gov/coronavirus/0,9753,7-406-98163-520743--,00.html.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled. COVID case and testing data will be posted three times a week on Mondays, Wednesdays and Fridays.

This report is provisional and subject to change. City of Detroit and Wayne County are reported separately. MDHHS began tracking probable cases April 5, 2020. FCI indicates federal correctional institute. MDOC indicates Michigan Department of Corrections. Diagnostic tests, including nucleic acid amplification/real-time …


Jamal Morton V. United States Virgin Islands Dec 2021

Jamal Morton V. United States Virgin Islands

2021 Decisions

USDC for the District Court of the Virgin Islands


Complement-Mediated Selective Tumor Cell Lysis Enabled By Bi-Functional Rna Aptamers, Hua Shi, Prabhat K. Mallik, Kimi Nishikawa, Pramit Mallik Dec 2021

Complement-Mediated Selective Tumor Cell Lysis Enabled By Bi-Functional Rna Aptamers, Hua Shi, Prabhat K. Mallik, Kimi Nishikawa, Pramit Mallik

Biological Sciences Faculty Scholarship

Unlike microbes that infect the human body, cancer cells are descended from normal cells and are not easily recognizable as “foreign” by the immune system of the host. However, if the malignant cells can be specifically earmarked for attack by a synthetic “designator”, the powerful effector mechanisms of the immune response can be conscripted to treat cancer. To implement this strategy, we have been developing aptamer-derived molecular adaptors to invoke synthetic immune responses against cancer cells. Here we describe multi-valent aptamers that simultaneously bind target molecules on the surface of cancer cells and an activated complement protein, which would tag …