Digital Commons Network^™

Exploration Of Dark Chemical Genomics Space Via Portal Learning: Applied To Targeting The Undruggable Genome And Covid-19 Anti-Infective Polypharmacology, Tian Cai, Li Xie, Muge Chen, Yang Liu, Di He, Shuo Zhang, Cameron Mura, Philip Boume, Lei Xie

Publications and Research

Advances in biomedicine are largely fueled by exploring uncharted territories of human biology. Machine learning can both enable and accelerate discovery, but faces a fundamental hurdle when applied to unseen data with distributions that differ from previously observed ones—a common dilemma in scientific inquiry. We have developed a new deep learning framework, called Portal Learning , to explore dark chemical and biological space. Three key, novel components of our approach include: (i) end-to-end, step-wise transfer learning, in recognition of biology’s sequence-structure-function paradigm, (ii) out-of-cluster meta-learning, and (iii) stress model selection. Portal Learning provides a practical solution to the out-of-distribution (OOD) …

Annual Report, Fiscal Year 2020/2021, Tennessee. Department Of Safety & Homeland Security.

Annual Report

No abstract provided.

Care And Compassion, Daisy Cuevas

Capstone Projects and Master's Theses

Many students who struggle with behavioral and mental health issues have a difficult time succeeding in school. Harden Middle School’s Wellness Center is where students struggling with socioemotional, mental, and behavioral health can come to receive support. The Care & Compassion program was created to address students who have more than five F’s or a zero-grade point average (GPA) and are failing classes at a high rate. A lack of parental and student engagement in distance learning, as well as depression due to isolation caused students to fall behind, fail classes and increased mental health concerns. Therefore, the Care & …

Queer Generational Connection Panel, Sam Hoffman

Capstone Projects and Master's Theses

This project was completed during my time working with the Epicenter in Salinas in their Our Gente program. Just as the program is designed to strengthen and support the LGBTQ+ youth and community in the area, this project seeks to address a growing gap between generations within the LGBTQ+ community. This gap grows due to a lack of both technological literacy, social in-person isolation, and a lack of accessible LGBTQ+ elders to provide information and oral history to those younger generations within the community. This project aims to address this with the Queer Generational Connection Panel. The Queer Generational Connection …

The Importance Of Onboarding Training In Prevention Work, Cindy Alfaro-Andasol

Capstone Projects and Master's Theses

Monarch Services is a nonprofit organization in Santa Cruz County that helps survivors of domestic violence, sexual assault, and human trafficking. Violence can affect all people regardless of age, sex, socioeconomical status, and legal status. That is why Monarch Services strives to put an end to all violence in our community by empowering individuals, families, and communities to act against violence and abuse. Their mission is to have people's lives be free from violence and abuse. Some contributing factors to increased violence in our community are culture and substance abuse. This can cause a great toll on a survivor's mental …

Out Of A Darkness: A Collection Of Ramblings, Short Stories, And Poetry, Valerie Anthony

Capstone Projects and Master's Theses

A Collection of Poetry, Short Stories and Ramblings

Rainbow Impostors: Impostor Syndrome In The Lgbtq+ Community, Kira C. Rideout

Capstone Projects and Master's Theses

Most people do not enjoy feeling like they are not enough or as like they are not a part of their community. As human beings we are social creatures and our communities play an essential role both in our development as we grow up and for our overall emotional well-being as we continue to live our lives. When people feel like they are an outcast or like they are not contributing to the progress of their community it can have a negative impact on their state of mind. This sense of self-doubt can cause individuals to realize their fear of …

Women Veterans Needs Assessment, Yezzenia Dena

Capstone Projects and Master's Theses

The Military & Veterans Affairs Office in Monterey County stated 20,674 veterans. They provide advocacy, assistance, and services designed to enhance the lives of the county’s veterans who served their country in the Armed Forces, their families, and their survivors. While this purpose is both efficient and admirable, there are still unmet needs in the veteran community. Increasing the support for women veterans within the veteran community requires further effort to address adequately. They are addressing this by understanding the contributing factors, several of which are related to stigma, lack of understanding services, and trauma. This survey took a closer …

Mental Health Awareness Among Watsonville Youth, Yajaira Rea

Capstone Projects and Master's Theses

Watsonville PAL is a non-profit agency that is funded by donations or community sponsors. Watsonville PAL works with the city of Watsonville and the Police department to help youth stay out of trouble. Watsonville PAL offers an amount of programs that as well relies on educational and recreational activities to keep youth busy and focus on school and heading to the right path and most importantly be a positive influence in their community. Watsonville is a community where the highest percentage of population are Latinos, who work all the time to feed their families and try to survive. While this …

Call For 2022 Issue // Palara Publication Guidelines, The Editors

PALARA: Publication of the Afro-Latin/American Research Association

No abstract provided.

Full Issue, The Editors

PALARA: Publication of the Afro-Latin/American Research Association

No abstract provided.

Front Matter, The Editors

PALARA: Publication of the Afro-Latin/American Research Association

No abstract provided.

La Piel De Kim Shou, Carlos Wynter Melo

PALARA: Publication of the Afro-Latin/American Research Association

No abstract provided.

Manuel Zapata Olivella 19202004: Pensador Político Radical Y Hereje De A Diáspora Africana En Las Américas By George Palacios, Dawn F. Stinchcomb

PALARA: Publication of the Afro-Latin/American Research Association

No abstract provided.

Book Announcement, The Editors

PALARA: Publication of the Afro-Latin/American Research Association

No abstract provided.

On The Role Of Matrix-Weights Elements In Consensus Algorithms For Multi-Agent Systems, Joshua Ogbebor, Xiangyu Meng

Faculty Publications

This paper examines the roles of the matrix weight elements in matrix-weighted consensus. The consensus algorithms dictate that all agents reach consensus when the weighted graph is connected. However, it is not always the case for matrix weighted graphs. The conditions leading to different types of consensus have been extensively analysed based on the properties of matrix-weighted Laplacians and graph theoretic methods. However, in practice, there is concern on how to pick matrix-weights to achieve some desired consensus, or how the change of elements in matrix weights affects the consensus algorithm. By selecting the elements in the matrix weights, different …

Spatially Periodic Vapor Bubble Activity During Subcooled Pool Boiling On 1d Aluminum Alloy Micro-Fin Arrays, Brendon Doran, Bin Zhang, Shayan Davani, Kojo Asiamah Osafo, Owen Sutka, Abigail Walker, Nicholas Mueller, Stephen Akwaboa, Patrick Mensah, W. J. Meng, Arden L. Moore

Faculty Publications

Within the broad field of micro- and nano- scale surface modification to improve pool boiling performance, micro-fin arrays are especially attractive due to their ability to significantly increase wetted surface area with minimal increase in size or weight compared to macroscopic fins. In addition, their regular and repeating geometry enables greater potential for parametric optimization, uniformity, and repeatability as compared to more randomized alternatives. However, the presence of a regular, repeating microscale pattern on a heated surface has previously been shown to create alternating regions of liquid and vapor flow at small length scales which can strongly affect the macroscopic …

Experimental Investigation Of The Aerodynamics Of A Large Industrial Building With Parapet, Aly Mousaad Aly, Matthew Thomas, Hamzeh Gol-Zaroudi

Faculty Publications

The aerodynamic performance of a roof depends significantly on its shape and size, among other factors. For instance, large roofs of industrial low-rise buildings may behave differently compared to those of residential homes. The main objective of this study is to experimentally investigate how perimeter solid parapets can alter the flow pattern around a low-rise building with a large aspect ratio of width/height of about 7.6, the case of industrial buildings/shopping centers. Solid parapets of varied sizes are added to the roof and tested in an open-jet simulator in a comparative study to understand their impact on roof pressure coefficients. …

Preliteracy Development Of Sound Blending: Teaching Consonant Vowel Consonant Words Through Differentiated Instructional Strategies, Grace Guenther

Theses/Capstones/Creative Projects

This capstone project reports the interventions, progress, and results of five elementary students who were identified as ‘at-risk’ for preliteracy reading skill acquisition. The capstone discusses differentiated instructional strategies and the rotation of intervention strategies utilized to increase the preliteracy skills of the students. The capstone discusses the interventions implemented across four weeks between the collection of baseline and final data. This research finds that students at-risk for acquiring preliteracy skills can increase their preliteracy skills through differentiated instructional strategies.

Terror Tactics: Vehicular Attacks In Israel, Garrett Smith

Honors Theses

Vehicular ramming attacks are a relatively new phenomenon within transnational terrorism. Their use is concentrated heavily within Israel and the West Bank. Using data from the University of Maryland’s Global Terrorism Database, I conduct an analysis of automobilebased terrorist attacks in Israel and the West Bank. I identify examine the relationship between Israeli counterterrorism policy, specifically the institution of barriers to physical movement, and the adoption of vehicle ramming tactics. These walls and checkpoints inadvertently provoke vehicle ramming attacks, even if effective at reducing firearm and explosive-based attacks. Exploration of existing literature on terrorist tactic selection suggests that vehicular attacks …

Determining The Presence Of Biological Fluids In Peruvian Mummy Cloths Using The Liquid Chromatography Quadruple Time Of Flight Instrument, Tim Perksen, Joshua Sebree Ph.D.

Fall 2021 - Chemical Analysis Class Projects

A poster presenting the processes used and the results of analyzing the cloth from Peruvian mummies for the presence of biological fluids.

Identification Of Natural Dyes In Ancient Peruvian Mummy Cloths Using Lc/Ms/Ms, Shailah Mathews, Joshua Sebree Ph.D.

Fall 2021 - Chemical Analysis Class Projects

A poster presenting the processes used and the results of analyzing the natural dyes used on cloth from Peruvian mummies.

Detecting Oceanic Salt In Peruvian Mummy Cloths Using Scanning Electron Microscopy, Alexis Wirtz, Joshua Sebree Ph.D.

Fall 2021 - Chemical Analysis Class Projects

A poster presenting the processes and the results of analyzing cloth from Peruvian mummies for the presence of ocean salts.

Coilreef™ Wave Energy Dissipation Project, Cole Ramsdale, Josh Sparrow, Kyle Archibald, Fernando Romero

Mechanical Engineering

Within this Final Design Review (FDR) report, the COILReef™ Senior Project concludes with all updates reflecting results after testing. The COILReef™ is a device ideated by Cal Poly Professor Roger Benham. It aims to provide a removeable, low-cost solution to dissipating ocean wave energy, thereby reducing coastal erosion in sensitive areas. Current permanent solutions cost millions of dollars, take years to construct, and sometimes produce undesirable and unintended effects. The work presented in this document provides the foundational research, testing, and steps taken by the team to evaluate the feasibility of the COILReef™ design as a viable solution to reducing …

Automated Mini-Tubular Ceramic Production, Hunter Brooks, Daniel Freeman, Leo Taranta-Slack

Mechanical Engineering

Researchers at Lawrence Livermore National Laboratory need a way to increase the rate of manufacturing of mini-tubular ceramics to be used in testing particulate air filters. This document outlines our process from researching and writing an initial scope of work all the way to fabricating and testing a final prototype. This journey takes us through the background research, ideation process and selection of a final design. We also detail the desired engineering specifications and our concept selection process. We dedicate a significant portion of this report to discussion of our final design. We delve into how it was manufactured as …

Gaf Fiberglass Mat Slitter Blade Sharpener, Mark D. Breaux, Bradley M. Smith, Esteban Carrillo, Carlos Espinoza

Mechanical Engineering

This document contains an overview for the offline slitter blade sharpening system created for GAF to sharpen their current cutting tools in a timely and safe manner without hindering the timeline and production of their assembly line. This design was developed by four undergraduate students at from Cal Poly, San Luis Obispo. This document first investigates background information of any patents, current sharpening device, sharpening safety standards, or literature review that may be useful in a sharpening mechanism device. This document also contains our design concept prototype, which consists of three main features, the use of a top guard for …

Break The Ice Challenge, Peter Karkos, Alex Lewis, Eva Kouyate, Vy Han

Mechanical Engineering

The report documents and justifies team LEGION’s senior design project, from research and ideation to prototype manufacturing and testing. It begins by providing some background on the project and outlining the mission scenario given by NASA. This is followed by related literature on excavation of icy regolith on the moon, water transportation, lunar environment, and space law. Next, research is performed into existing products, such as patents and various designs from previous related NASA competitions.

After providing the relevant background information, focused objectives are outlined, with a problem statement, boundary sketch, and engineering specifications. The wants & needs of NASA …

Produce Sorting Aid, Annica Navarro, Jessie Boucher, Natalie Roberts, Teng Lee

Mechanical Engineering

This Final Design Review (FDR) document intends to define the details of the Produce Sorting Aid senior project–selected by four mechanical engineering students, working under the team name Team W24. The Alameda County Community Foodbank (ACCFB) sorts bulk produce into bags or boxes for distribution to people in need of food. However, the current process is not ergonomic, time efficient, or safe for the volunteers at the ACCFB. The scope of the senior project is to design a mechanism that is ergonomic, time efficient, and safe for the volunteers to lift heavy produce and distribute the produce into bags ready …

The Role Of The Serine/Threonine Phosphatase Pstp In The Mycobacterial Cell Wall Regulation, Farah Shamma

Biology Dissertations - Archive

Mycobacterium tuberculosis (Mtb) is the causative agent of the deadly infection Tuberculosis (TB). The current standard antibiotic regimen for TB treatment combines fours drugs to be taken for at least six months. Mtb shows intrinsic phenotypic tolerance to antibiotics contributing to the long treatment regimen. In addition, Mtb cells can achieve a non-replicating state exhibiting antibiotic tolerance, reduced metabolism and altered cell wall staining. The changes in the cell wall and reduced permeability to antibiotics in stressed cells suggest that the regulation of the cell wall is a major contributor to antibiotic tolerance. The mycobacterial cell wall consists of covalently …

Identification Of Resilience Dimensions And Development Of A Decision-Making System To Measure The Resilience Level Of Highway Networks, Thahomina Jahan Nipa

Civil Engineering Dissertations - Archive

Local as well as national economy and safety depend on the network characteristics of the transportation infrastructures. Destruction of transportation infrastructures causes the direct cost of the reconstruction as well as indirect cost due to loss of mobility. In addition, emergency response and recovery cannot be rendered if access to the affected community is hampered due to a damaged transportation network. Hence, researchers as well national and international organizations are focusing more on a resilience-based approach instead of a traditional recovery-based approach for the transportation infrastructures recently. As a result, there exist a high number of research articles that developed …